JP3815526B2 - Catheter tube and catheter using the same - Google Patents

Description

[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a catheter tube for use in medical surgery and a catheter using the same. More specifically, the present invention has a passage for allowing a guide wire to pass therethrough, and is inserted into a lesioned portion on the basis of a guidewire leading to the lesion site. The present invention relates to a catheter used for diagnosis and treatment.
[0002]
[Prior art]
A catheter is a medical device that is inserted into the human body for diagnostic and therapeutic purposes. In many cases, particularly in the vascular system, it is necessary to insert along the blood vessel from the insertion port to the lesioned part and a predetermined site for the purpose of the dilatation catheter, and the operability and shape retention of the dilatation catheter are important. The operability and shape retention will be described in detail. The catheter is generally composed of a cylindrical elongated member, and the catheter is operated from the outside of the body through the insertion port to bend or narrow in the body. Flexibility and bending so that the axial force applied from the outside of the catheter body and the rotating force must be effectively transmitted to the tip, and must be able to handle the bent part. Anti-kink property that does not bend even at the part is necessary.
[0003]
Further, the high operability required for the catheter is extremely lowered when its shape is deformed. In other words, the tube-shaped member of the catheter is important for transmitting the operation at hand by the operator to the distal end of the catheter. is there. The inside of the tubular member is often used through a guide wire during treatment, but when the catheter enters the bent part, the tubular member through which the guide wire passes is bent and deformed, increasing the friction between the catheter and the guide wire. The operability sometimes deteriorated. In addition, when the tubular member of the catheter was clamped with a hemostatic connector outside the body, a phenomenon was observed in which the operability of the guide wire was reduced due to compression deformation of the inner tubular member due to mishandling. Furthermore, as in these examples, small deformations accumulate even if they are not subjected to extreme deformation, and the gradual deterioration of operability during the operation contributes to the fact that the catheter cannot withstand long-term use. It is believed that.
[0004]
As described above, it is clear that the catheter does not deform in catheterization, that is, its shape retention is important. The problem is that tube-shaped members used in conventional catheters are not restored to their original shape once they are deformed, and the operability remains low. It was unavoidable. This is because the elastic recovery of the catheter member is poor and permanent distortion tends to remain. Elastomer materials are examples of materials having good elastic recovery rate, but elastomers alone are too soft, and friction between elastomers and extracorporeal tissues, guide catheters, and guide wires is large, making it difficult to apply to dilatation catheters.
[0005]
In order to solve these problems, the present inventor has proposed a tubular member having a layer structure of two or more layers formed from a thermoplastic elastomer and other polymer material as disclosed in JP-A-9-75443. Used as a catheter tube, the bending stiffness represented by the product of the tensile modulus of the thermoplastic elastomer and the cross-sectional second moment of the thermoplastic elastomer part is that of the tensile modulus and the cross-sectional second moment of the polymer material other than the thermoplastic elastomer. It is possible to solve the problem by configuring it so that it is greater than the bending rigidity represented by the product, or by configuring the thickness of the thermoplastic elastomer layer to be thicker than the thickness of the other polymer material constituting the catheter tube. We are trying to solve it.
[0006]
Although this method is extremely effective, the polyolefin is placed in the innermost layer due to poor weldability and adhesiveness with thermoplastic elastomers and other polymer materials, especially polyolefins with excellent sliding properties with guide wires. In order to maintain the adhesion, there is a dimensional shape limitation that the polyolefin layer must have a certain degree of shape retention, that is, a certain thickness. That is, from the gist of the invention described in the above-mentioned publication, it is advantageous that the thermoplastic elastomer layer is thick, but if the inner layer has poor adhesion, the inner layer itself needs to be thick in order to prevent peeling and deformation. As a result, this is a phenomenon in which the thickness of the thermoplastic elastomer layer is limited. In addition, it was necessary to pay attention throughout the entire process from extrusion to assembly so as not to cause deformation and breakage between layers.
[0007]
[Problems to be solved by the invention]
If the catheter is deformed or bent due to various causes, the catheter remains deformed and the force transmission is reduced, or the guide wire passing inner tube remains deformed and the friction resistance with the guide wire The operability decreased due to the increase in In order to solve these problems, it has been proposed that a tubular member having a layer structure of two or more layers formed from a thermoplastic elastomer and other polymer material is used as a catheter tube. When polyolefin was used, the mutual weldability was not good, so there were limitations on size and shape and difficulty in production. Accordingly, the present invention has an object to provide an excellent catheter tube having improved anti-kink properties, shape retention properties, particularly shape recovery properties, and no deterioration in maneuverability, and a catheter using the same. And Further, the invention described in JP-A-9-75443 is developed to provide a catheter tube that is more effective and stable in the manufacturing process, and a catheter using the same.
[0008]
[Means for Solving the Problems]
The catheter tube according to the present invention is a catheter tube in which an outer portion of a tube is made of a polymer material having good compatibility with polyolefin, and an inner portion is made of a polyolefin material, and the high tube that forms the outer portion of the tube. The molecular material is a blend of a polymer material having a solubility parameter larger than that of polyolefin and a compatibilizing material having an effect of enhancing the polyolefin compatibility of the material, and the polymer material having a solubility parameter larger than the polyolefin is a polyamide. It is at least one component selected from an elastomer, a polyester elastomer, a polyurethane elastomer, a polyamide resin, and a polyester resin, and the compatibilizing material is a styrenic thermoplastic elastomer, a graft copolymer of polyethylene and polystyrene, a poly Lopylene and polystyrene graft copolymer, ethylene-glycidyl methacrylate copolymer and polystyrene graft copolymer, ethylene vinyl acetate copolymer and polystyrene graft copolymer, polyethylene and polymethyl methacrylate graft copolymer, polypropylene And polymethyl methacrylate graft copolymer, ethylene-glycidyl methacrylate copolymer and polymethyl methacrylate graft copolymer, ethylene vinyl acetate copolymer and polymethyl methacrylate graft copolymer, polyethylene and acrylonitrile-styrene copolymer Graft copolymer of polymer, graft copolymer of polypropylene and acrylonitrile-styrene copolymer, ethylene-glycidyl methacrylate copolymer and acrylonitrile-styrene Graft copolymer of polymer, graft copolymer of ethylene vinyl acetate copolymer and acrylonitrile-styrene copolymer, graft copolymer of ethylene-ethyl acrylate-maleic anhydride copolymer and polystyrene, ethylene-ethyl For catheters selected from graft copolymers of acrylate-maleic anhydride copolymer and polymethyl methacrylate, and graft copolymers of ethylene-ethyl acrylate-maleic anhydride copolymer and acrylonitrile-styrene copolymer A tube,
The compatibilizing material is a hydrogenated saturated styrene thermoplastic elastomer or an acid-modified hydrogenated saturated styrene thermoplastic elastomer, or
The polymer material constituting the outer part of the tube is a polymer alloy composed of acid-modified hydrogenated saturated polystyrene-polybutadiene type styrenic thermoplastic elastomer (SEBS) and polyethylene terephthalate resin, and the inner part is made of polyethylene. Co-extruded and molded, or
The polymer material constituting the outer portion of the tube is a polymer alloy composed of acid-modified hydrogenated saturated polystyrene-polybutadiene type styrene thermoplastic elastomer (SEBS) and polyester thermoplastic elastomer, and the inner portion is polyethylene. They are characterized by co-extrusion and molding , and achieve the above object.
[0011]
Further, in the above case, it is also preferable to introduce a crosslink into the polyolefin portion by irradiation with radiation.
[0012]
Further, the catheter of the present invention uses the above-mentioned catheter tube to connect an expansion body to the tip of a shaft of a conventionally known structure, for example, an inner / outer double tube structure, and a lumen for expansion / contraction of the expansion body to the shaft. And a dilatation catheter having a structure in which a guide wire passage lumen is formed.
[0013]
DETAILED DESCRIPTION OF THE INVENTION
Next, embodiments of the present invention will be described in more detail. Block copolymer materials, graft copolymer materials, or materials having a solubility parameter (SP value) of 7.7 to 9.4 (cal / cm ³ ) ^1/2 , which contain components that are compatible with polyolefin, are extruded. Thermoplastic resins that can be processed into a tube shape by molding are preferable, and since they have a block copolymer structure and a graft copolymer structure, they often have excellent creep properties and elastic recovery properties. When the outer portion of the catheter tube is configured, it is preferable because the catheter is imparted with anti-kinking property, shape retention property, particularly shape restoration property. Further, the block copolymer material and the graft copolymer material are particularly preferable for the above reasons. For example, styrenic thermoplastic elastomers, polyester thermoplastic elastomers, urethane thermoplastic elastomers, polyamide thermoplastics. Examples thereof include elastomers and polyolefin-based thermoplastic elastomers.
[0014]
These thermoplastic elastomers are block copolymer materials or graft copolymer materials containing components that are compatible with at least one polyolefin or have a solubility parameter (SP value) of 7.7 to 9.4 (cal / cm ³ ). ^The type is not particularly limited as long as it is a thermoplastic polymer material that is ^1/2 , and may be determined according to the properties required for the catheter to be applied. For example, styrene-butadiene-based styrene thermoplastic elastomer, fat Examples thereof include a urethane-based thermoplastic elastomer containing a large amount of a group-based polyol component, a polyamide-based thermoplastic elastomer or a polyester-based thermoplastic elastomer containing a polyolefin component in the molecular structure, and a polyolefin-based thermoplastic elastomer.
[0015]
A material consisting of a blend of a polymer material having a solubility parameter larger than that of polyolefin and a compatibilizing material capable of compatibilizing the polyolefin with the material can be processed into a tube shape by extrusion molding. When the outer portion of the catheter tube is configured, it is preferable that the catheter has physical properties that impart anti-kinking properties, shape retention properties, particularly shape restoration properties. The polymer material having a solubility parameter larger than that of polyolefin is not particularly limited because it usually increases elastomeric properties when blended with a compatibilizing agent and improves elastic recovery and low creep properties. Examples thereof include polyamide elastomers, polyester elastomers, polyurethane elastomers, polyamide resins, and polyester resins that are excellent in mechanical properties.
[0016]
The compatibilizing material is not particularly limited as long as it is a compatibilizing material having an action of compatibilizing polyolefin with a polymer material having a solubility parameter larger than that of polyolefin, and examples thereof include acid-modified styrenic heat. Plastic elastomer (f-SEBS), graft copolymer of polyethylene and polystyrene, graft copolymer of polypropylene and polystyrene, graft copolymer of ethylene-glycidyl methacrylate copolymer and polystyrene, ethylene vinyl acetate copolymer and polystyrene Graft copolymer, graft copolymer of polyethylene and polymethyl methacrylate, graft copolymer of polypropylene and polymethyl methacrylate, graft copolymer of ethylene-glycidyl methacrylate copolymer and polymethyl methacrylate , Graft copolymer of ethylene vinyl acetate copolymer and polymethyl methacrylate, graft copolymer of polyethylene and acrylonitrile-styrene copolymer, graft copolymer of polypropylene and acrylonitrile-styrene copolymer, ethylene- Graft copolymer of glycidyl methacrylate copolymer and acrylonitrile-styrene copolymer, graft copolymer of ethylene vinyl acetate copolymer and acrylonitrile-styrene copolymer, ethylene-ethyl acrylate-maleic anhydride copolymer And polystyrene graft copolymer, ethylene-ethyl acrylate-maleic anhydride copolymer and polymethyl methacrylate graft copolymer, ethylene-ethyl acrylate-maleic anhydride copolymer and acrylonitrile-styrene copolymer Graft copolymer, and the like.
[0017]
Preferred embodiments of the present invention are shown below. This embodiment is an example in which the catheter tube of the present invention is applied to a guide wire passing tube of an expansion catheter for expanding a body passage. FIG. 1 is a schematic view of the dilatation catheter of the present embodiment, FIG. 2 is a cross-sectional view taken along line AA in FIG. 1, FIG. 3 is a cross-sectional view taken along line BB in FIG. The expanded sectional view of the tube for passage is shown. The invention will be further understood by reference to the drawings.
[0018]
FIG. 1 shows the dilatation catheter of this embodiment with the dilator expanded. In FIG. 1, the dilatation catheter has an outer tubular member proximal side (outer tube) 1, an outer tubular member distal side (outer tube) 2, and an inner tubular member (inner tube) 3 arranged inside thereof. The outer tube 2 is connected to the expansion body 5 at the expansion body proximal portion 4. Here, the proximal outer tube 1 is set to have a larger inner diameter and outer diameter than the distal outer tube 2, but is not particularly limited to this structure. The inner tube 3 passes through the inside of the expansion body 5 and is connected to the expansion body 5 at the expansion body distal portion 6. An X-ray impermeable marker 7 is attached at a position on the circumference of the inner tube 3 and corresponding to the central portion of the expansion body 5. The radiopaque marker 7 is made of a radiopaque material such as gold, platinum, tungsten, and alloys thereof.
[0019]
The inner tube 3 is connected to a wire port 9 of a manifold 8 disposed in the proximal portion of the catheter. In actual use, a guide wire is inserted from the wire port 9 and penetrates through the catheter. The catheter is guided to the lesion site for treatment in advance. The space between the inner and outer tubes is connected to the expansion port 10 of the manifold at the proximal portion of the catheter, and a liquid (saline solution, contrast medium) for expanding the expansion body 5 introduced from the expansion port 10 is a space of the inner and outer tubes. The pressure is transmitted into the expansion body 5 through the structure having the communication property. The use of guidewires and dilatation catheters in the implementation of the above PTCA is well known to those skilled in the art. In use, the catheter is inserted through the blood vessel to the target lesion under the guidance of a guide wire.
[0020]
4 and 5, the characteristic catheter tube structure in the present invention is a tube-shaped member for allowing a guide wire to pass therethrough, in the embodiment, the structure of the inner tube 3, and its outer portion 11 is Block copolymer material or graft copolymer material containing a component compatible with at least one polyolefin, or heat having a solubility parameter (SP value) of 7.7 to 9.4 (cal / cm ³ ) ^1/2 It is made of a material composed of a blend of a plastic polymer material or a polymer material having a solubility parameter larger than that of polyolefin and a compatibilizing material having a function of compatibilizing the material with polyolefin, and an inner portion 12 thereof. Is made of a polyolefin material. As shown in FIG. 4, the interface between the materials of the outer part 11 and the inner part 12 may not be recognized as shown in FIG. 4, and the interface may be recognized relatively visually as shown in FIG. It was. These are due to the solubility characteristics between the materials and the tube molding conditions. One of the means is to improve the adhesion between the material constituting the outer portion 11 and the material constituting the polyolefin inner portion 12. No particular distinction is made from the object of the invention.
[0021]
Moreover, in the above-mentioned embodiment, the example of the inner and outer double tube structure was shown as the shaft structure of the catheter of the present invention, but the parallel shaft in which the guide wire passing tube and the expansion / contraction tube of the expansion body are bundled side by side. A structure may be used.
[0022]
【Example】
Example 1
Hydrogenated saturated polystyrene-polybutadiene type styrene system having a solubility parameter (SP value) of 8.2 (cal / cm ³ ) ^1/2 , a density (specific gravity) of 0.93, and a melt flow rate (MFR) of 1.0. A thermoplastic elastomer (SEBS) and polyethylene having a density of 0.96 and MFR 0.7 are formed into a tube shape by using a co-extrusion apparatus so that the outer side is SEBS and the inner side is polyethylene. It shape | molded so that thickness ratio might become substantially outer side part: inner side part = 1: 1. The boundary between both materials was not clear as shown in FIG. The tube was assembled as the inner tube 3 of the catheter as shown in FIG. In this case, since the catheter tube, that is, the inner tube 3 according to the present invention has a structure in which the material constituting the outer portion 11 and the polyethylene constituting the inner portion 12 are combined, excellent anti-kinking properties In addition, shape retention and shape restoration were observed. Moreover, since the inner side part 12 was polyethylene, it was good in slidability and became an inner tubular member with good guide wire operability. Moreover, since the material which comprises the outer part 11 and the polyethylene which comprises the inner part 12 were taken as the structure, the peeling between both materials at the time of an assembly and use did not occur at all.
[0023]
(Example 2)
Acid-modified hydrogenated saturated polystyrene-polybutadiene type styrene thermoplastic elastomer (SEBS) having a solubility parameter (SP value) of 8.2 (cal / cm ³ ) ^1/2 , density of 0.92, and MFR 2.2. ) And polyethylene having a density of 0.96 and MFR of 0.7, using a co-extrusion device, the outer part is SEBS and the inner part is a polyethylene tube, and the calculated wall thickness ratio is Molding was performed so that the outer portion: the inner portion = 5: 1. The boundary between both materials was not clear as shown in FIG. The tube was assembled as the inner tube 3 of the catheter as shown in FIG. In this case, since the tube for catheter according to the present invention, that is, the inner tube 3 has a composite structure in which the material constituting the outer portion 11 and the polyethylene constituting the inner portion 12 are completely bonded, Excellent anti-kink properties, shape retention and shape restoration were observed. Moreover, since the inner side part 12 was polyethylene, it was good in slidability and became an inner tubular member with good guide wire operability. Moreover, since the material which comprises the outer part 11 and the polyethylene which comprises the inner part 12 were taken as the structure, the peeling between both materials at the time of an assembly and use did not occur at all.
[0024]
Example 3
Acid-modified hydrogenated saturated polystyrene-polybutadiene type styrene thermoplastic elastomer (SEBS) having a solubility parameter (SP value) of 8.2 (cal / cm ³ ) ^1/2 , density of 0.92, and MFR 2.2. ) And polyethylene having a density of 0.96 and MFR of 0.7, using a co-extrusion device, the outer part is SEBS and the inner part is a polyethylene tube, and the calculated wall thickness ratio is Molding was performed so that the outer portion: the inner portion = 5: 1. The boundary between both materials was not clear as shown in FIG. The tube was irradiated with an electron beam at a dose of 50 kGy, and then assembled as an inner tube 3 of a catheter as shown in FIG. In this case, since the catheter tube, that is, the inner tube 3 according to the present invention has a structure in which the material constituting the outer portion 11 and the polyethylene constituting the inner portion 12 are combined, excellent anti-kinking properties In addition, shape retention and shape restoration were observed. Moreover, since the inner side part 12 was polyethylene, it was good in slidability and became an inner tubular member with good guide wire operability. Moreover, since the material which comprises the outer part 11 and the polyethylene which comprises the inner part 12 were taken as the structure, the peeling between both materials at the time of an assembly and use did not occur at all. Furthermore, in the case of Example 3, when the polyethylene part was cross-linked by electron beam irradiation, the knitting of the polyethylene part was suppressed even after heating during the catheter assembly process, and improved workability was observed. was there.
[0025]
Example 4
Acid-modified hydrogenated saturated polystyrene-polybutadiene type styrene thermoplastic elastomer (SEBS) having a solubility parameter (SP value) of 8.2 (cal / cm ³ ) ^1/2 , density of 0.92, and MFR 2.2. ) And an intrinsic viscosity of 1.17 and a polymer alloy containing 50% by weight of a polyethylene terephthalate resin having a density of 1.34, and a polyethylene having a density of 0.96 and an MFR of 0.7, using an coextrusion device. The polymer alloy was molded into a tube shape in such an arrangement that the inner part was polyethylene, and the calculated thickness ratio was approximately outer part: inner part = 1: 1. The boundary between both materials was not clear as shown in FIG. The tube was assembled as the inner tube 3 of the catheter as shown in FIG. In this case, since the catheter tube, that is, the inner tube 3 according to the present invention has a structure in which the material constituting the outer portion 11 and the polyethylene constituting the inner portion 12 are combined, excellent anti-kinking properties In addition, shape retention and shape restoration were observed. Moreover, since the inner side part 12 was polyethylene, it was good in slidability and became an inner tubular member with good guide wire operability. Moreover, since the material which comprises the outer part 11 and the polyethylene which comprises the inner part 12 were taken as the structure, the peeling between both materials at the time of an assembly and use did not occur at all.
[0026]
(Example 5)
Acid-modified hydrogenated saturated polystyrene-polybutadiene type styrene thermoplastic elastomer (SEBS) having a solubility parameter (SP value) of 8.2 (cal / cm ³ ) ^1/2 , density of 0.92, and MFR 2.2. ), A polymer alloy containing 50% by weight of a polyester thermoplastic elastomer having a density of 1.26 and MFR13, and a polyethylene having a density of 0.96 and MFR of 0.7, respectively, using a co-extrusion device, the outer part is a polymer alloy. The tube was formed in such an arrangement that the inner part was made of polyethylene, and the calculated thickness ratio was approximately outer part: inner part = 1: 1. The boundary between the two materials was fairly clear as shown in FIG. 5, but both materials were in a strong welded state. The tube was assembled as the inner tube 3 of the catheter as shown in FIG. In this case, the catheter tube according to the present invention, i.e., the inner tube 3, has a structure in which the material constituting the outer portion 11 and the polyethylene constituting the inner portion 12 are completely joined together, and thus has excellent anti-kinking properties. In addition, shape retention and shape restoration were observed. Moreover, since the inner side part 12 was polyethylene, it was good in slidability and became an inner tubular member with good guide wire operability. In addition, since the material constituting the outer portion 11 and the polyethylene constituting the inner portion 12 are completely combined, no separation between the two materials during use or during use occurred.
[0027]
As shown in the examples, the catheter tube of the present invention and the catheter using the same have a structure in which the material constituting the outer portion 11 and the polyolefin constituting the inner portion 12 are combined, so that deformation is not caused. Even if added, the shape of the polyolefin portion constituting the inner portion 12 is easily retained by the shape recoverability of the catheter tube. That is, since the shape of the guide wire passing tube is maintained, the force transferability is not lowered, and the friction resistance with the guide wire is not increased, so that the operability is improved. Further, due to its shape recoverability, there was no deterioration in operability over time seen in general catheters.
[0028]
【The invention's effect】
According to the present invention consisting of the above contents, since the shape retaining property of the guide wire passing tube is excellent, the force transmission property does not decrease, the friction resistance with the guide wire does not increase, and the operability is improved. An improved catheter with no deterioration in operability over time can be provided.
[Brief description of the drawings]
FIG. 1 is an overall schematic view of a dilatation catheter showing an example of the present invention.
FIG. 2 is a cross-sectional view taken along line AA in FIG.
FIG. 3 is a cross-sectional view taken along line BB in FIG.
FIG. 4 is a cross-sectional view illustrating the catheter tube of the present invention or the inner tube of the catheter.
FIG. 5 is an explanatory sectional view showing the catheter tube or the inner tube of the catheter.
[Explanation of symbols]
1 Outer tubular member proximal side (outer tube)
2 Outer tubular member distal side (outer tube)
3 Inner tubular member (inner tube)
4 Expansion body proximal part 5 Expansion body 6 Expansion body distal part 7 X-ray opaque marker 8 Manifold 9 Wire port 10 Expansion port 11 Outer part 12 Inner part

Claims (5)

A catheter tube in which the outer part of the tube is made of a polymer material having good compatibility with polyolefin and the inner part is made of a polyolefin material, and the polymer material constituting the outer part of the tube has a higher solubility than polyolefin. A polymer material comprising a polymer material having a parameter and a compatibilizing material having an action of increasing the polyolefin compatibility of the material, and the polymer material having a solubility parameter larger than the polyolefin is a polyamide elastomer, a polyester elastomer, a polyurethane elastomer, It is at least one component selected from a polyamide resin and a polyester resin, and the compatibilizing material is a styrene thermoplastic elastomer, a graft copolymer of polyethylene and polystyrene, a graph of polypropylene and polystyrene Copolymer, ethylene-glycidyl methacrylate copolymer and polystyrene graft copolymer, ethylene vinyl acetate copolymer and polystyrene graft copolymer, polyethylene and polymethyl methacrylate graft copolymer, polypropylene and polymethyl methacrylate Graft copolymer, graft copolymer of ethylene-glycidyl methacrylate copolymer and polymethyl methacrylate, graft copolymer of ethylene vinyl acetate copolymer and polymethyl methacrylate, graft copolymer of polyethylene and acrylonitrile-styrene copolymer Polymer, graft copolymer of polypropylene and acrylonitrile-styrene copolymer, graft copolymer of ethylene-glycidyl methacrylate copolymer and acrylonitrile-styrene copolymer, ethylene Vinyl acetate copolymer and acrylonitrile-styrene copolymer graft copolymer, ethylene-ethyl acrylate-maleic anhydride copolymer and polystyrene graft copolymer, ethylene-ethyl acrylate-maleic anhydride copolymer A catheter tube selected from the group consisting of a graft copolymer of ethylene and polymethyl methacrylate, a graft copolymer of ethylene-ethyl acrylate-maleic anhydride copolymer and acrylonitrile-styrene copolymer , wherein said compatibilizing A catheter tube , wherein the material is a hydrogenated saturated styrene thermoplastic elastomer or an acid-modified hydrogenated saturated styrene thermoplastic elastomer . A catheter tube in which the outer part of the tube is made of a polymer material having good compatibility with polyolefin and the inner part is made of a polyolefin material, and the polymer material constituting the outer part of the tube has a higher solubility than polyolefin. A polymer material comprising a polymer material having a parameter and a compatibilizing material having an action of increasing the polyolefin compatibility of the material, and the polymer material having a solubility parameter larger than the polyolefin is a polyamide elastomer, a polyester elastomer, a polyurethane elastomer, It is at least one component selected from a polyamide resin and a polyester resin, and the compatibilizing material is a styrene thermoplastic elastomer, a graft copolymer of polyethylene and polystyrene, a graph of polypropylene and polystyrene Copolymer, ethylene-glycidyl methacrylate copolymer and polystyrene graft copolymer, ethylene vinyl acetate copolymer and polystyrene graft copolymer, polyethylene and polymethyl methacrylate graft copolymer, polypropylene and polymethyl methacrylate Graft copolymer, graft copolymer of ethylene-glycidyl methacrylate copolymer and polymethyl methacrylate, graft copolymer of ethylene vinyl acetate copolymer and polymethyl methacrylate, graft copolymer of polyethylene and acrylonitrile-styrene copolymer Polymer, graft copolymer of polypropylene and acrylonitrile-styrene copolymer, graft copolymer of ethylene-glycidyl methacrylate copolymer and acrylonitrile-styrene copolymer, ethylene Vinyl acetate copolymer and acrylonitrile-styrene copolymer graft copolymer, ethylene-ethyl acrylate-maleic anhydride copolymer and polystyrene graft copolymer, ethylene-ethyl acrylate-maleic anhydride copolymer A catheter tube selected from a graft copolymer of polymethylmethacrylate, a graft copolymer of ethylene-ethyl acrylate-maleic anhydride copolymer and acrylonitrile-styrene copolymer , outside the tube The polymer material constituting the part is a polymer alloy composed of acid-modified hydrogenated saturated polystyrene-polybutadiene type styrenic thermoplastic elastomer (SEBS) and polyethylene terephthalate resin, the inner part is polyethylene, and they are co-extruded. especially the fact that molded A tube for catheters. A catheter tube in which the outer part of the tube is made of a polymer material having good compatibility with polyolefin and the inner part is made of a polyolefin material, and the polymer material constituting the outer part of the tube has a higher solubility than polyolefin. A polymer material comprising a polymer material having a parameter and a compatibilizing material having an action of increasing the polyolefin compatibility of the material, and the polymer material having a solubility parameter larger than the polyolefin is a polyamide elastomer, a polyester elastomer, a polyurethane elastomer, It is at least one component selected from a polyamide resin and a polyester resin, and the compatibilizing material is a styrene thermoplastic elastomer, a graft copolymer of polyethylene and polystyrene, a graph of polypropylene and polystyrene Copolymer, ethylene-glycidyl methacrylate copolymer and polystyrene graft copolymer, ethylene vinyl acetate copolymer and polystyrene graft copolymer, polyethylene and polymethyl methacrylate graft copolymer, polypropylene and polymethyl methacrylate Graft copolymer, graft copolymer of ethylene-glycidyl methacrylate copolymer and polymethyl methacrylate, graft copolymer of ethylene vinyl acetate copolymer and polymethyl methacrylate, graft copolymer of polyethylene and acrylonitrile-styrene copolymer Polymer, graft copolymer of polypropylene and acrylonitrile-styrene copolymer, graft copolymer of ethylene-glycidyl methacrylate copolymer and acrylonitrile-styrene copolymer, ethylene Vinyl acetate copolymer and acrylonitrile-styrene copolymer graft copolymer, ethylene-ethyl acrylate-maleic anhydride copolymer and polystyrene graft copolymer, ethylene-ethyl acrylate-maleic anhydride copolymer A catheter tube selected from a graft copolymer of polymethylmethacrylate, a graft copolymer of ethylene-ethyl acrylate-maleic anhydride copolymer and acrylonitrile-styrene copolymer , outside the tube The polymer material constituting the part is a polymer alloy composed of acid-modified hydrogenated polystyrene-polybutadiene type styrene-based thermoplastic elastomer (SEBS) and polyester-based thermoplastic elastomer, and the inner part is made of polyethylene. that it was formed by extrusion A catheter tube characterized by the above . The catheter tube according to any one of claims 1 to 3 , wherein crosslinking is introduced into the polyolefin portion by electron beam irradiation. A catheter comprising the catheter tube according to any one of claims 1 to 4 .

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