JP3739100B2 - Low temperature crosslinking gel - Google Patents
Low temperature crosslinking gel Download PDFInfo
- Publication number
- JP3739100B2 JP3739100B2 JP19055093A JP19055093A JP3739100B2 JP 3739100 B2 JP3739100 B2 JP 3739100B2 JP 19055093 A JP19055093 A JP 19055093A JP 19055093 A JP19055093 A JP 19055093A JP 3739100 B2 JP3739100 B2 JP 3739100B2
- Authority
- JP
- Japan
- Prior art keywords
- weight
- parts
- acid
- gel
- hydroxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Colloid Chemistry (AREA)
Description
【０００１】
【産業上の利用分野】
本発明は、低温架橋型ゲル基剤及び低温架橋型ゲル製剤に関する。さらに詳しくは、Ａ：エタノール及び／又はイソプロパノール、ポリアクリル酸及び／又はその塩類並びに難溶性多価金属化合物、Ｂ：ヒドロキシ酸及び水のＡ，Ｂ両成分を３０℃以下で混合し、ｐＨを４〜６とした低温架橋型ゲル基剤、及び更にこの基剤に活性成分を含有せしめたゲル製剤に関する。
【０００２】
【従来の技術】
従来、化粧用パック剤や、外用剤の基剤として数多くのものが知られている。
【０００３】
例えば、パック剤用の基剤としてポリアクリル酸ナトリウムと水酸化アルミニウムゲル、軽質無水硅酸または含水硅酸及び水とからなるパック用基剤（特開昭５９−９３０１２）が知られている。又パップ剤用の基剤として、水溶性高分子物質を含有する膏体中に架橋剤として水酸化アルミナマグネシウムを配合したパップ剤用基剤（特公平４−５０２９１）や、ポリアクリル酸ナトリウムなどの水溶性高分子物質、架橋剤としてのアルミニウムグリシネート又は水酸化アルミニウムゲル、更にアルコール、ゼラチンを配合したアルコール含有貼付剤基剤（特公平４−３４９６５）などが知られている。
【０００４】
【発明が解決しようとする課題】
上記パック用基剤は、ポリアクリル酸ナトリウムと水酸化アルミニウムゲルによって高含水性ゲルを形成する。しかし、このゲルは多量の水分を含有するため、経時的に水分がしみ出したり、或いはゲルを形成する前に不織布より膏体がはみ出したりする。そしてそのような点を抑えるために架橋剤の水酸化アルミニウムゲルを増すと、硬くなって不織布上に均一に展延出来なかったりする。また、パップ剤用の基剤において、前者の特公平４−５０２９１号公報記載の発明は従来のものの欠点がかなり改善されているが、ゼラチンの使用が望ましく、その場合加温が必要であり、熱分解し易い薬物や揮散し易い薬物を使用する場合は適切ではない。後者の特公平４−３４９６５号公報記載の基剤においてはアルコール（エタノール）が用いられており、難溶性かまたは油性の薬物を用いる場合に適切であるとされているが、ゼラチンを用いるため、やはり加温が必要である。そして実施例をみると４５℃位に冷却してからアルコールを添加しているが、４５℃ではエタノールはかなり揮散する。そして実際の製造現場では大量に仕込む必要があり、この大量のものを４５℃迄冷却するためにはかなりのコストがかかり経済的でない。
本発明は、上記の問題点を解決した、活性成分、特に熱分解し易い薬剤や、揮散し易い薬剤を含有せしめて経皮投与製剤とした場合でも薬剤の熱分解や揮散が起こらない経皮投与用ゲル基剤、あるいは、同様の問題点を解決した、活性成分として美肌成分などを含有せしめた化粧用パック剤等のゲル製剤を提供することを目的とする。
【０００５】
【課題を解決するための手段】
このような技術状況に鑑み、鋭意研究を重ねた結果、Ａ成分として、水溶性高分子物質であるポリアクリル酸及び／又はその塩類を、架橋剤である水酸化アルミナマグネシウムを用い、またエタノール及び／又はイソプロパノールを用い、またＢ成分としてヒドロキシ酸及び水を用いることによって、難溶性あるいは油性の活性成分を配合する場合に好都合で、かつ貼付時の冷却効果がすぐれ、またゼラチンを用いなくとも保形性が良好であると共にゼラチンの場合のような加温が不要のため種々の薬剤を含むゲル基剤が経済的に製造できることを見出し、本発明を完成した。
即ち、本発明は（１）下記Ａ，Ｂ両成分を３０℃以下で混合し、ｐＨを４〜６とした低温架橋型ゲル基剤：
Ａ：エタノール及び／又はイソプロパノール、ポリアクリル酸及び／又はその塩類並びに難溶性多価金属化合物
Ｂ：ヒドロキシ酸及び水、および
（２）活性成分を含有する又は含有しない上記（１）記載の低温架橋型ゲル基剤からなる低温架橋型ゲル製剤、に関するものである。
【０００６】
本発明において、Ａ成分として水溶性高分子であるポリアクリル酸及び／又はその塩類が用いられるが、これはゲルの主成分として用いられる。このポリアクリル酸塩としては、ポリアクリル酸ナトリウム、ポリアクリル酸カリウム等のポリアクリル酸の一価金属塩、ポリアクリル酸モノエタノールアミン、ポリアクリル酸ジエタノールアミン、ポリアクリル酸トリエタノールアミン等のポリアクリル酸のアミン塩、ポリアクリル酸のアンモニウム塩が挙げられるが、特に好的なものはアクリル酸ナトリウムである。ポリアクリル酸及び／又はその塩類の配合量は重量比で膏体全量の２〜１０％が好適である。
なお、ポリアクリル酸或はその塩類以外の水溶性高分子物質、例えばポリビニールアルコール、ポリビニルピロリドン、メトキシエチレン無水マレイン酸共重合体、メタクリル酸重合体或は多糖類系のアルギン酸ナトリウム、アルギン酸アンモニウム、カルボキシメチルセルロース、カルボキシメチルセルロースナトリウム、ヒドロキシメチルセルロース、ヒドロキシプロピルセルロース、ヒドロキシプロピルエチルセルロース、メチルセルロース、可溶性デンプン、カルボキシメチルアミロース、デキストリン等、その他ペクチン、寒天末等のヘミセルロース、アラビヤゴム、トラガカントゴム、キサンタンガム等の植物ゴム、アクリル酸デンプン等の高吸水性高分子等も勿論添加して差し支えない。
水溶性高分子物質全体の配合量は膏体全量に対し重量比で１〜２０％が好ましい。
【０００７】
Ａ成分の１つである難溶性多価金属化合物としては、水酸化アルミナマグネシウム、水酸化アルミニウム・炭酸水素ナトリウム共沈物、アルミニウムグリシネート、水酸化アルミニウムゲル等が使用できるが、２価のマグネシウム、３価のアルミニウムの両方が共存している水酸化アルミナマグネシウムが特に好適に使用できる。これらは架橋剤として用いられ、その配合量は、膏体全量に対し重量比で０．２〜３％が好適である。
又同じくＡ成分の１つ、エチルアルコール及び／又はイソプロピルアルコールの配合量は、膏体全量に対し重量比で２〜２０％が好適である。２％以下であると調製時ゲル化の反応が早くなり、薄く塗布することができなかったり、厚さのむらを生じたりする。２０％以上であるとゲル化の反応が遅くなり、支持体からのしみ出しや、はみ出しが生じる。
【０００８】
Ｂ成分であるヒドロキシ酸は保形性を良好に保持することができ、このヒドロキシ酸としては、酒石酸、クエン酸、乳酸、リンゴ酸、グリコール酸、グルコン酸、サリチル酸などが挙げられる。ヒドロキシ酸の添加量は、膏体全量に対し重量比で０．５〜５％が好適である。
本発明ゲル基剤の調製において、多価アルコール、例えばＤ−ソルビトール、グリセリン、１，３−ブタンジオール等を保湿剤として用いることができる。
その他、防腐剤や香料、着色料等も適宜配合して差し支えない。防腐剤としてはパラオキシ安息香酸メチル，パラオキシ安息香酸ブチル等のパラベン類，チモール，イソプロピルメチルフェノールなどが挙げられる。香料としてはペパーミント，スペアミントなどのミント系香料，レモン，オレンジなどのシトラス系香料及びその他の各種天然香料又は合成香料などが挙げられる。また，着色料としては各種合成色素（タール色素），天然色素，アルミニウムレーキ，顔料などが挙げられる。
【０００９】
本発明のゲル基剤は活性成分を更に含有させて低温架橋型ゲル製剤とすることができ、この活性成分としてはパック剤等に用いられる美肌成分等の非薬剤と、薬剤経皮吸収製剤として用いられる薬剤成分とがある。
本発明を例えばパック剤として用いる場合、配合する美肌成分としては特に制限されることはなく、従来のパック剤で用いられているアスコルビン酸又はそのエステル，プラセンターエキス，コウジ酸，桑白皮，グルタチオン，感光素などの美白剤，ヒアルロン酸，コラーゲン，ローヤルゼリー，アロエ，尿素などの保湿剤，イオウ，サリチル酸，レゾルシンなどの角質軟化剤，トラネキサム酸，アラントイン，グリチルリチン酸などの抗炎症剤，各種ビタミン剤等の各種の美肌用活性物質などを適宜、単独或いは組合せて使用することができる。
又、本発明を薬剤経皮吸収製剤として用いる場合、配合する薬剤としては、経皮吸収される薬剤であれば特に制限されず、局所的に使用する薬剤及び全身的に適用する薬剤いずれのものも使用される。例えば狭心症発作に対し、血管拡張剤であるニトログリセリン、硝酸イソソルビド、亜硝酸アミル等が挙げられ、気管支喘息に対し、鎮咳、去痰の作用があるフマル酸フォルモテロール、リン酸ジモルファン、クエン酸カルベタペンタン、塩酸プロカテロール等が挙げられる。更に、消炎鎮痛のためのサリチル酸メチル等のサリチル酸誘導体、ｌ−メントール、ｄｌ−カンフル、ノニル酸ワニリルアミド等の他、ジクロフェナクナトリウム、インドメタシン、ケトプロフェン、ピロキシカム、イブプロフェン等の非ステロイド系薬剤、トリアムシノロンアセトニド、デキサメタゾン、フルオロシノロンアセトニド等のステロイド系薬剤、あるいはジフェンヒドラミン、マレイン酸クロルフェニラミン等の抗ヒスタミン剤等が挙げられる。その他，塩酸エペリゾン，ダントロレンナトリウム等の骨格筋弛緩剤，塩酸モルヒネ，リン酸コディン等の麻薬等も無論使用することができる。
【００１０】
そして、本発明においては特に熱分解し易い美肌成分や薬剤、例えばアスコルビン酸又はそのエステル，レチノール又はそのエステル，ビタミンＡ油，酢酸ヒドロキソコバラミン，エルゴカルシフェノールなどのビタミン類，硝酸イソソルビド，ニトログリセリン，エナント酸テストステロン，酒石酸エルゴタミン，インスリンなどが挙げられる。揮発し易い美肌成分や薬物、例えばユーカリ油，ニクズク油，チアミン油，ハッカ油，メントール，カンフルなどのテルペン類，亜硝酸アミル，トリメタジオン等が好適に用いられる。
【００１１】
又、本発明では美肌成分、薬用成分共に入っていないゲル剤をそのまま、例えば不織布に塗布して低温架橋型アイマスク等として用いることもできる。
本発明のゲル基剤の調製は例えば下記方法によって行われる。
ヒドロキシ酸を必要量の精製水に溶解し、これに必要により多価アルコールを加えてＢ成分とする。次にポリアクリル酸及び／又はその塩と水酸化アルミナマグネシウムを混合し、更に必要によりポりアクリル酸又はその塩以外の水溶性高分子物質を加え、これにエタノール及び／又はイソプロパノールを加え充分撹拌し均一の混合物たるＡ成分とする。これに、先に調製したヒドロキシ酸の溶液Ｂを加え撹拌混合し、ゲル基剤とする。防腐剤を使用する時は、エタノール及び／又はイソプロパノールを加える際、それに混合溶解すればよい。
【００１２】
更に、本発明のゲル製剤は上記で得られたゲル基剤に適宜例えば美肌成分を加えてパック剤などにするか、或いは局所作用薬又は全身作用薬を調製時、適宜配合することによって得られる。この場合これらの美肌成分あるいは薬用成分は精製水，エタノール，イソプロパノール，多価アルコール又はその他の溶解剤に適宜，溶解又は分散して配合する。
本発明において、低温架橋型ゲル基剤及び該製剤のｐＨを４〜６とするが、これはＡ成分とＢ成分のｐＨがゲル強度や架橋速度並びに美肌成分あるいは薬用成分の安定性に大きく影響するためである。例えばこれ以外の範囲ではｐＨが高いとゲル形成が遅延されたり経時的にゲルから水が放出しやすくなる。反対にｐＨが低いと架橋速度が速いため均一なゲルが得られなかったり，貼付剤とする場合は展延出来なかったりゲル強度が弱いため皮膚残りが生じたりする。
【００１３】
【発明の効果】
本発明のゲル基剤は、上記の如くゼラチンを使用しないため調製時加熱する必要がなく、又エタノールやイソプロパノールを配合しているため、パック剤やパップ剤として使用する場合、冷却効果が良好であるというすぐれた効果を有する。難溶性薬剤や油性の薬剤、また熱分解し易い薬剤或いは揮散し易い薬剤を配合する場合も好都合であり全く問題がない。
【００１４】
【実施例】
実施例１
エタノール５．０重量部にパラオキシ安息香酸メチル０．１重量部を加え溶解させる。さらにポリアクリル酸ナトリウム５．０重量部、水酸化アルミナマグネシウム０．２５重量部、カルボキシメチルセルロースナトリウム２．０重量部及び濃グリセリン１５．０重量部を加え、混合分散し、Ａ液とする。
別に精製水５６．１５重量部に酒石酸１．５重量部及びＤ−ソルビトール液１５．０重量部を加え完全溶解し、Ｂ液とする。
Ａ，Ｂ両液を２０℃で混合し、ｐＨ４．８の低温架橋型ゲル基剤を得た。
【００１５】
実施例２
エタノール１０．０重量部にパラオキシ安息香酸メチル０．１重量部及びポリアクリル酸１．０重量部を加え溶解させる。さらにポリアクリル酸ナトリウム５．０重量部、水酸化アルミナマグネシウム０．３重量部、アクリル酸デンプン１．０重量部及び１，３−ブタンジオール５．０重量部を加え、混合分散し、Ａ液とする。
別に精製水６６．６重量部に酒石酸１．０重量部及びＤ−ソルビトール液１０．０重量部を加え完全溶解し、Ｂ液とする。
Ａ，Ｂ両液を５℃で混合し、ｐＨ４．２の低温架橋型ゲル基剤を得た。
【００１６】
実施例３
イソプロパノール５．０重量部にパラオキシ安息香酸メチル０．１重量部及びポリアクリル酸１．０重量部を加え溶解させる。さらにポリアクリル酸ナトリウム３．０重量部、水酸化アルミナマグネシウム０．１５重量部、カルボキシメチルセルロースナトリウム３．０重量部及び濃グリセリン１５．０重量部を加え、混合分散し、Ａ液とする。
別に精製水６６．７５重量部に乳酸１．０重量部及び濃グリセリン５．０重量部を加え完全溶解し、Ｂ液とする。
Ａ，Ｂ両液を２０℃で混合し、ｐＨ４．１の低温架橋型ゲル基剤を得た。
【００１７】
実施例４
エタノール３．０重量部にパラオキシ安息香酸メチル０．１重量部を加え溶解させる。さらにポリアクリル酸ナトリウム６．０重量部、水酸化アルミナマグネシウム０．２重量部、カルボキシメチルセルロースナトリウム１．０重量部、１，３−ブタンジオール５．０重量部及び濃グリセリン１０．０重量部を加え、混合分散し、Ａ液とする。
別に精製水６３．７重量部にリンゴ酸１．０重量部及びＤ−ソルビトール液１０．０重量部を加え完全溶解し、Ｂ液とする。
Ａ，Ｂ両液を２０℃で混合し、ｐＨ５．４の低温架橋型ゲル基剤を得た。
【００１８】
実施例５
エタノール５．０重量部にパラオキシ安息香酸メチル０．１重量部を加え溶解させる。さらにポリアクリル酸ナトリウム４．０重量部、水酸化アルミナマグネシウム０．２重量部、カルボキシメチルセルロースナトリウム２．０重量部及び濃グリセリン１５．０重量部を加え、混合分散し、Ａ液とする。
別に精製水５７．２重量部に酒石酸１．５重量部及びＤ−ソルビトール１５．０重量部を加え完全溶解し、Ｂ液とする。
Ａ，Ｂ両液を２０℃で混合し、不織布上に塗付量が２，０００ｃｍ2／１００ｇになるように塗付、裁断し、ｐＨ４．６の低温架橋型アイマスクシートを得た。
【００１９】
実施例６
エタノール５．０重量部にパラオキシ安息香酸メチル０．１重量部を加え溶解させる。さらにポリアクリル酸ナトリウム４．０重量部、水酸化アルミナマグネシウム０．３重量部、アクリル酸デンプン２．０重量部、１，３−ブタンジオール５．０重量部及び濃グリセリン１０．０重量部を加え、混合分散し、Ａ液とする。
別に精製水７１．６重量部に酒石酸１．５重量部及びアスコルビン酸リン酸マグネシウム０．５重量部を加え完全溶解し、Ｂ液とする。
Ａ，Ｂ両液を２０℃で混合し、不織布上に塗付量が２，０００ｃｍ2／１００ｇになるように塗付、裁断し、ｐＨ５．５の低温架橋型フェイスマスクシートを得た。
【００２０】
実施例７
エタノール５．０重量部にビタミンＡ油１．０重量部、酢酸トコフェロール０．５重量部及びパラオキシ安息香酸メチル０．１重量部を加え溶解させる。さらにポリアクリル酸ナトリウム５．０重量部、水酸化アルミナマグネシウム０．３重量部、カルボキシメチルセルロースナトリウム２．０重量部及び濃グリセリン１５．０重量部を加え、混合分散し、Ａ液とする。
別に精製水６０．１重量部に酒石酸１．０重量部及びＤ−ソルビトール液１０．０重量部を加え完全溶解し、Ｂ液とする。
Ａ，Ｂ両液を１５℃で混合し、不織布上に塗付量が２，０００ｃｍ2／１００ｇになるように塗付、裁断し、ｐＨ５．２の低温架橋型アイパックシートを得た。
【００２１】
実施例８
エタノール５．０重量部にユーカリ油０．５重量部、ニクズク油０．５重量部、チミアン油０．３重量部、ｌ−メントール０．７重量部、ｄｌ−カンフル１．０重量部及びパラオキシ安息香酸メチル０．１重量部を加え溶解させる。さらにポリアクリル酸ナトリウム５．０重量部、水酸化アルミナマグネシウム０．２５重量部、カルボキシメチルセルロースナトリウム２．０重量部及び濃グリセリン１５．０重量部を加え、混合分散し、Ａ液とする。
別に精製水５３．１５重量部に酒石酸１．５重量部及びＤ−ソルビトール液１５．０重量部を加え完全溶解し、Ｂ液とする。
Ａ，Ｂ両液を１０℃で混合し、不織布上に塗付量が９００ｃｍ2／１００ｇになるように塗付、裁断し、ｐＨ５．２の低温架橋型かぜ用パップ剤を得た。
【００２２】
実施例９
イソプロパノール１０．０重量部に硝酸イソソルビド５．０重量部及びパラオキシ安息香酸メチル０．１重量部を均一分散させる。さらにポリアクリル酸ナトリウム５．０重量部、水酸化アルミナマグネシウム０．４重量部、アクリル酸デンプン２．０重量部、１，３−ブタンジオール１０．０重量部及び濃グリセリン１０．０重量部を加え、混合分散し、Ａ液とする。
別に精製水２６．５重量部に酒石酸１．０重量部及びＤ−ソルビトール液３０．０重量部を加え完全溶解し、Ｂ液とする。
Ａ，Ｂ両液を２０℃で混合し、不織布上に塗付量が２，０００ｃｍ2／１００ｇになるように塗付、裁断し、ｐＨ５．２の低温架橋型経皮吸収貼付剤を得た。
【００２３】
実施例１０
エタノール５．０重量部にインドメタシン０．５重量部、ｌ−メントール１．０重量部及びパラオキシ安息香酸メチル０．１重量部を加え溶解させる。さらにポリアクリル酸ナトリウム５．０重量部、水酸化アルミナマグネシウム０．３重量部、アクリル酸デンプン２．０重量部及び１，３−ブタンジオール５．０重量部を加え、混合分散し、Ａ液とする。
別に精製水６０．１重量部に酒石酸１．０重量部及びＤ−ソルビトール液２０．０重量部を加え完全溶解し、Ｂ液とする。
Ａ，Ｂ両液を２０℃で混合し、不織布上に塗付量が１，０００ｃｍ2／１００ｇになるように塗付、裁断し、ｐＨ５．３の低温架橋型消炎鎮痛外用貼付剤を得た。
実施例における配合割合を次の表にまとめて示す。
【００２４】
【表１】
[Industrial application fields]
The present invention relates to a low temperature crosslinkable gel base and a low temperature crosslinkable gel preparation. More specifically, A: ethanol and / or isopropanol, polyacrylic acid and / or salts thereof and a hardly soluble polyvalent metal compound, B: hydroxy acid and water A and B components are mixed at 30 ° C. or less, and the pH is adjusted. The present invention relates to a low-temperature cross-linking gel base having 4 to 6 and a gel preparation further containing an active ingredient in this base.
[0002]
[Prior art]
Conventionally, many things are known as a base for cosmetic packs and external preparations.
[0003]
For example, as a base material for a pack agent, a base material for a pack made of sodium polyacrylate and aluminum hydroxide gel, light anhydrous succinic acid or hydrous oxalic acid and water (Japanese Patent Laid-Open No. 59-93012) is known. In addition, as a base for poultices, a base for poultices (Japanese Patent Publication No. 4-50291) in which a plaster containing a water-soluble polymer substance is mixed with alumina magnesium hydroxide as a crosslinking agent, sodium polyacrylate, etc. Water-soluble polymer materials, aluminum glycinate or aluminum hydroxide gel as a crosslinking agent, alcohol-containing patch base (Japanese Patent Publication No. 4-34965) containing alcohol and gelatin are also known.
[0004]
[Problems to be solved by the invention]
The pack base forms a highly hydrous gel with sodium polyacrylate and aluminum hydroxide gel. However, since this gel contains a large amount of moisture, the moisture oozes out over time, or the plaster oozes out of the nonwoven fabric before the gel is formed. And if aluminum hydroxide gel of a crosslinking agent is increased in order to suppress such a point, it will become hard and cannot spread uniformly on a nonwoven fabric. Further, in the base for cataplasm, the former invention described in Japanese Examined Patent Publication No. 4-50291 has considerably improved the disadvantages of the conventional one, but the use of gelatin is desirable, in which case heating is required, It is not appropriate when using drugs that are easily pyrolyzed or drugs that are easily volatilized. Alcohol (ethanol) is used in the base described in the latter Japanese Patent Publication No. 4-34965, and it is said that it is suitable when a poorly soluble or oily drug is used. However, since gelatin is used, After all heating is necessary. And when an example is seen, after cooling to about 45 degreeC, alcohol is added, but ethanol will volatilize considerably at 45 degreeC. And it is necessary to prepare a large amount at an actual manufacturing site, and cooling this large amount to 45 ° C. requires a considerable cost and is not economical.
The present invention solves the above-mentioned problems, and the active ingredient, particularly a drug that is easily decomposed by heat, or a drug that easily volatilizes is contained, and even when a preparation for transdermal administration is prepared, the drug does not undergo thermal decomposition or volatilization. It is an object of the present invention to provide a gel preparation such as a gel base for administration, or a cosmetic pack that contains a beautifying skin component as an active ingredient and solves the same problems.
[0005]
[Means for Solving the Problems]
In view of such a technical situation, as a result of intensive research, as a component A, polyacrylic acid and / or its salt, which is a water-soluble polymer substance, is used as a cross-linking agent, magnesium alumina hydroxide, and ethanol and Use of isopropanol and / or hydroxy acid and water as the B component are advantageous when blending poorly soluble or oily active ingredients, have an excellent cooling effect at the time of application, and can be maintained without using gelatin. The inventors have found that a gel base containing various drugs can be produced economically because the shapeability is good and heating as in the case of gelatin is unnecessary, and the present invention has been completed.
That is, the present invention is (1) a low-temperature cross-linked gel base prepared by mixing the following components A and B at 30 ° C. or lower and adjusting the pH to 4-6:
A: Ethanol and / or isopropanol, polyacrylic acid and / or salts thereof, and poorly soluble polyvalent metal compound B: hydroxy acid and water, and (2) low-temperature crosslinking as described in (1) above or not containing an active ingredient The present invention relates to a low-temperature cross-linked gel preparation comprising a gel gel base.
[0006]
In the present invention, polyacrylic acid and / or a salt thereof, which is a water-soluble polymer, is used as the A component, and this is used as the main component of the gel. Examples of the polyacrylate include monovalent metal salts of polyacrylic acid such as sodium polyacrylate and potassium polyacrylate, polyacrylic acid such as monoethanolamine polyacrylate, diethanolamine polyacrylate, and triethanolamine polyacrylate. Examples of the acid amine salt and polyacrylic acid ammonium salt include sodium acrylate. The blending amount of polyacrylic acid and / or a salt thereof is preferably 2 to 10% of the total amount of the plaster by weight ratio.
Water-soluble polymeric substances other than polyacrylic acid or its salts, such as polyvinyl alcohol, polyvinyl pyrrolidone, methoxyethylene maleic anhydride copolymer, methacrylic acid polymer or polysaccharide sodium alginate, ammonium alginate, Carboxymethylcellulose, sodium carboxymethylcellulose, hydroxymethylcellulose, hydroxypropylcellulose, hydroxypropylethylcellulose, methylcellulose, soluble starch, carboxymethylamylose, dextrin, other pectin, hemicellulose such as agar powder, arabiya gum, tragacanth gum, xanthan gum and other plant rubber, acrylic Of course, a superabsorbent polymer such as acid starch may be added.
The total amount of the water-soluble polymer substance is preferably 1 to 20% by weight with respect to the total amount of the plaster.
[0007]
As the hardly soluble polyvalent metal compound which is one of the A components, magnesium aluminate hydroxide, aluminum hydroxide / sodium bicarbonate coprecipitate, aluminum glycinate, aluminum hydroxide gel, etc. can be used. Alumina magnesium hydroxide in which both trivalent aluminum coexists can be used particularly preferably. These are used as a crosslinking agent, and the blending amount is preferably 0.2 to 3% by weight with respect to the total amount of the plaster.
Similarly, the blending amount of one of the component A, ethyl alcohol and / or isopropyl alcohol is preferably 2 to 20% by weight with respect to the total amount of the paste. If it is 2% or less, the gelation reaction is accelerated at the time of preparation, so that it cannot be applied thinly or unevenness in thickness occurs. If it is 20% or more, the gelation reaction slows down, and exudation or exudation from the support occurs.
[0008]
The hydroxy acid which is the component B can keep its shape retention well, and examples of the hydroxy acid include tartaric acid, citric acid, lactic acid, malic acid, glycolic acid, gluconic acid, salicylic acid and the like. The addition amount of the hydroxy acid is preferably 0.5 to 5% by weight with respect to the total amount of the plaster.
In the preparation of the gel base of the present invention, a polyhydric alcohol such as D-sorbitol, glycerin, 1,3-butanediol and the like can be used as a humectant.
In addition, preservatives, fragrances, coloring agents and the like may be appropriately mixed. Examples of preservatives include parabens such as methyl paraoxybenzoate and butyl paraoxybenzoate, thymol, and isopropylmethylphenol. Examples of the fragrances include mint fragrances such as peppermint and spearmint, citrus fragrances such as lemon and orange, and other various natural or synthetic fragrances. Examples of colorants include various synthetic dyes (tar dyes), natural dyes, aluminum lakes, and pigments.
[0009]
The gel base of the present invention can further contain an active ingredient to form a low-temperature cross-linking gel preparation. As this active ingredient, a non-drug such as a beautifying skin ingredient used in packs and the like, and a drug transdermal absorption preparation. There are drug components used.
For example, when the present invention is used as a pack agent, it is not particularly limited as a skin beautifying component, and ascorbic acid or its ester, placenta extract, kojic acid, mulberry skin bark used in conventional pack agents, Whitening agents such as glutathione, photosensitizers, moisturizers such as hyaluronic acid, collagen, royal jelly, aloe, urea, keratin softeners such as sulfur, salicylic acid, resorcin, anti-inflammatory agents such as tranexamic acid, allantoin, glycyrrhizic acid, various vitamins Various active substances for skin beautifying agents such as agents can be used alone or in combination as appropriate.
In addition, when the present invention is used as a drug transdermally absorbable preparation, the drug to be blended is not particularly limited as long as it is a drug that can be absorbed transdermally. Also used. For example, for angina attacks, vasodilators such as nitroglycerin, isosorbide nitrate, amyl nitrite, etc., have antitussive and expectorant effects on bronchial asthma, formoterol fumarate, dimorphan phosphate, citric acid Examples include carbetapentane and procaterol hydrochloride. In addition to salicylic acid derivatives such as methyl salicylate for anti-inflammatory analgesia, 1-menthol, dl-camphor, nonylic acid vanillylamide, etc., non-steroidal drugs such as diclofenac sodium, indomethacin, ketoprofen, piroxicam, ibuprofen, triamcinolone acetonide, And steroidal drugs such as dexamethasone and fluorocinolone acetonide, and antihistamines such as diphenhydramine and chlorpheniramine maleate. In addition, skeletal muscle relaxants such as eperisone hydrochloride and dantrolene sodium, and narcotics such as morphine hydrochloride and codine phosphate can of course be used.
[0010]
And in the present invention, a skin-beautifying component or a drug that is particularly susceptible to thermal decomposition, such as ascorbic acid or its ester, retinol or its ester, vitamins such as vitamin A oil, hydroxocobalamin acetate, ergocalciphenol, isosorbide nitrate, nitroglycerin, Examples include testosterone enanthate, ergotamine tartrate, and insulin. The volatilizing beautifying skin components and drugs, for example, terpenes such as eucalyptus oil, nutmeg oil, thiamine oil, mint oil, menthol, camphor, amyl nitrite, trimetadione, etc. are preferably used.
[0011]
In the present invention, the gel agent which is not contained in both the beautifying skin component and the medicinal component can be directly applied to, for example, a non-woven fabric to be used as a low-temperature crosslinking eye mask.
The gel base of the present invention is prepared, for example, by the following method.
A hydroxy acid is dissolved in a necessary amount of purified water, and a polyhydric alcohol is added thereto as necessary to obtain a component B. Next, polyacrylic acid and / or salt thereof and magnesium alumina hydroxide are mixed, and if necessary, water-soluble polymer substance other than acrylic acid or salt thereof is added, and ethanol and / or isopropanol is added thereto and stirred sufficiently. A component which is a uniform mixture. To this, the solution B of hydroxy acid prepared earlier is added and mixed with stirring to obtain a gel base. When using preservatives, when ethanol and / or isopropanol are added, they may be mixed and dissolved.
[0012]
Furthermore, the gel preparation of the present invention can be obtained by adding, for example, a beautifying skin component to the gel base obtained above to make a pack or the like, or by appropriately blending a local or systemic agent during preparation. . In this case, these skin beautifying ingredients or medicinal ingredients are blended by appropriately dissolving or dispersing in purified water, ethanol, isopropanol, polyhydric alcohol or other solubilizers.
In the present invention, the pH of the low-temperature cross-linking gel base and the preparation is set to 4-6. This is because the pH of the A component and the B component greatly affects the gel strength, the cross-linking speed, and the stability of the skin beautifying component or the medicinal component. It is to do. For example, when the pH is high in other ranges, gel formation is delayed or water is easily released from the gel over time. On the other hand, if the pH is low, a uniform gel cannot be obtained because the crosslinking rate is high, and when it is used as a patch, it cannot be spread, or the gel strength is weak, resulting in skin residue.
[0013]
【The invention's effect】
Since the gel base of the present invention does not use gelatin as described above, it does not need to be heated at the time of preparation, and since it contains ethanol or isopropanol, it has a good cooling effect when used as a pack or poultice. It has an excellent effect of being. In the case of blending a poorly soluble drug, an oily drug, a drug easily decomposed by heat, or a drug that easily volatilizes, there is no problem at all.
[0014]
【Example】
Example 1
To 5.0 parts by weight of ethanol, 0.1 part by weight of methyl paraoxybenzoate is added and dissolved. Further, 5.0 parts by weight of sodium polyacrylate, 0.25 parts by weight of magnesium aluminate hydroxide, 2.0 parts by weight of sodium carboxymethylcellulose, and 15.0 parts by weight of concentrated glycerin are added, mixed and dispersed to obtain Liquid A.
Separately, 1.5 parts by weight of tartaric acid and 15.0 parts by weight of D-sorbitol solution are added to 56.15 parts by weight of purified water and completely dissolved to obtain solution B.
Both A and B solutions were mixed at 20 ° C. to obtain a low temperature cross-linked gel base having a pH of 4.8.
[0015]
Example 2
To 10.0 parts by weight of ethanol, 0.1 part by weight of methyl paraoxybenzoate and 1.0 part by weight of polyacrylic acid are added and dissolved. Further, 5.0 parts by weight of sodium polyacrylate, 0.3 parts by weight of magnesium aluminate hydroxide, 1.0 part by weight of starch acrylate and 5.0 parts by weight of 1,3-butanediol were added, mixed and dispersed, and solution A And
Separately, 1.0 part by weight of tartaric acid and 10.0 parts by weight of D-sorbitol solution are added to 66.6 parts by weight of purified water and completely dissolved to obtain a solution B.
Both A and B solutions were mixed at 5 ° C. to obtain a low temperature cross-linked gel base having a pH of 4.2.
[0016]
Example 3
To 5.0 parts by weight of isopropanol, 0.1 part by weight of methyl paraoxybenzoate and 1.0 part by weight of polyacrylic acid are added and dissolved. Further, 3.0 parts by weight of sodium polyacrylate, 0.15 part by weight of magnesium aluminate hydroxide, 3.0 parts by weight of sodium carboxymethylcellulose, and 15.0 parts by weight of concentrated glycerin are added, mixed and dispersed to obtain Liquid A.
Separately, 1.0 part by weight of lactic acid and 5.0 parts by weight of concentrated glycerin are added to 66.75 parts by weight of purified water and completely dissolved to obtain solution B.
Both A and B liquids were mixed at 20 ° C. to obtain a low temperature cross-linked gel base having a pH of 4.1.
[0017]
Example 4
0.1 parts by weight of methyl paraoxybenzoate is added to 3.0 parts by weight of ethanol and dissolved. Further, 6.0 parts by weight of sodium polyacrylate, 0.2 parts by weight of magnesium aluminate hydroxide, 1.0 part by weight of sodium carboxymethylcellulose, 5.0 parts by weight of 1,3-butanediol and 10.0 parts by weight of concentrated glycerin In addition, it is mixed and dispersed to make liquid A.
Separately, 1.0 part by weight of malic acid and 10.0 parts by weight of D-sorbitol solution are added to 63.7 parts by weight of purified water and completely dissolved to obtain a solution B.
Both A and B solutions were mixed at 20 ° C. to obtain a low temperature cross-linked gel base having a pH of 5.4.
[0018]
Example 5
To 5.0 parts by weight of ethanol, 0.1 part by weight of methyl paraoxybenzoate is added and dissolved. Further, 4.0 parts by weight of sodium polyacrylate, 0.2 parts by weight of magnesium aluminate hydroxide, 2.0 parts by weight of sodium carboxymethylcellulose and 15.0 parts by weight of concentrated glycerin are added, mixed and dispersed to obtain Liquid A.
Separately, 1.5 parts by weight of tartaric acid and 15.0 parts by weight of D-sorbitol are added to 57.2 parts by weight of purified water and completely dissolved to obtain solution B.
A, were mixed B both liquids at 20 ° C., coat-like coat-weight on the nonwoven fabric is 2,000 cm 2/100 g, was cut to obtain a low-temperature crosslinking type eye mask sheet pH 4.6.
[0019]
Example 6
To 5.0 parts by weight of ethanol, 0.1 part by weight of methyl paraoxybenzoate is added and dissolved. Furthermore, 4.0 parts by weight of sodium polyacrylate, 0.3 parts by weight of alumina magnesium hydroxide, 2.0 parts by weight of starch acrylate, 5.0 parts by weight of 1,3-butanediol and 10.0 parts by weight of concentrated glycerin were added. In addition, it is mixed and dispersed to make liquid A.
Separately, 1.5 parts by weight of tartaric acid and 0.5 parts by weight of magnesium ascorbate phosphate are added to 71.6 parts by weight of purified water and completely dissolved to obtain solution B.
A, were mixed B both liquids at 20 ° C., coat-like coat-weight on the nonwoven fabric is 2,000 cm 2/100 g, was cut to obtain a low-temperature crosslinking type face mask sheet pH 5.5.
[0020]
Example 7
To 5.0 parts by weight of ethanol, 1.0 part by weight of vitamin A oil, 0.5 parts by weight of tocopherol acetate and 0.1 parts by weight of methyl parahydroxybenzoate are added and dissolved. Further, 5.0 parts by weight of sodium polyacrylate, 0.3 parts by weight of magnesium aluminate hydroxide, 2.0 parts by weight of sodium carboxymethylcellulose and 15.0 parts by weight of concentrated glycerin are added, mixed and dispersed to obtain Liquid A.
Separately, 1.0 part by weight of tartaric acid and 10.0 parts by weight of D-sorbitol solution are added to 60.1 parts by weight of purified water and completely dissolved to obtain a solution B.
A, were mixed with B two solutions to 15 ° C., coat-like coat-weight on the nonwoven fabric is 2,000 cm 2/100 g, was cut to obtain a low cross-linked eye pack sheets pH 5.2.
[0021]
Example 8
5.0 parts by weight of ethanol, 0.5 parts by weight of eucalyptus oil, 0.5 parts by weight of nutmeg oil, 0.3 parts by weight of thymian oil, 0.7 parts by weight of l-menthol, 1.0 part by weight of dl-camphor and paraoxy Add 0.1 parts by weight of methyl benzoate and dissolve. Further, 5.0 parts by weight of sodium polyacrylate, 0.25 parts by weight of magnesium aluminate hydroxide, 2.0 parts by weight of sodium carboxymethylcellulose, and 15.0 parts by weight of concentrated glycerin are added, mixed and dispersed to obtain Liquid A.
Separately, 1.5 parts by weight of tartaric acid and 15.0 parts by weight of D-sorbitol solution are added to 53.15 parts by weight of purified water and completely dissolved to obtain solution B.
A, were mixed with B both liquid 10 ° C. and coated with such a coating with the amount on the nonwoven fabric is 900 cm 2/100 g, was cut to obtain a low-temperature crosslinking type wind for cataplasm of pH 5.2.
[0022]
Example 9
To 10.0 parts by weight of isopropanol, 5.0 parts by weight of isosorbide nitrate and 0.1 parts by weight of methyl parahydroxybenzoate are uniformly dispersed. Furthermore, 5.0 parts by weight of sodium polyacrylate, 0.4 parts by weight of magnesium aluminate hydroxide, 2.0 parts by weight of starch acrylate, 10.0 parts by weight of 1,3-butanediol and 10.0 parts by weight of concentrated glycerin In addition, it is mixed and dispersed to make liquid A.
Separately, 1.0 part by weight of tartaric acid and 30.0 parts by weight of D-sorbitol solution are added to 26.5 parts by weight of purified water and completely dissolved to obtain a solution B.
A, were mixed B both liquids at 20 ° C., coat-like coat-weight on the nonwoven fabric is 2,000 cm 2/100 g, was cut to obtain a low-temperature crosslinking transdermal patch of the pH5.2 .
[0023]
Example 10
To 5.0 parts by weight of ethanol, 0.5 parts by weight of indomethacin, 1.0 parts by weight of 1-menthol and 0.1 parts by weight of methyl parahydroxybenzoate are added and dissolved. Further sodium polyacrylate 5.0 parts by weight, 0.3 parts by weight of alumina hydroxide magnesium, and 2.0 parts by weight of starch acrylate, and 1,3-butanediol O Le 5.0 parts by weight was added and mixed and dispersed, A Use liquid.
Separately, 1.0 part by weight of tartaric acid and 20.0 parts by weight of D-sorbitol solution are added to 60.1 parts by weight of purified water and completely dissolved to obtain a solution B.
A, were mixed B both liquids at 20 ° C., coat-like coat-weight on the nonwoven fabric is 1,000 cm 2/100 g, was cut to obtain a low cross-linked anti-inflammatory analgesic external patch of pH5.3 .
The blending ratios in the examples are summarized in the following table.
[0024]
[Table 1]
Claims (9)
Ａ：エタノール及び／又はイソプロパノール、ポリアクリル酸及び／又はその塩類並びに水酸化アルミナマグネシウム、水酸化アルミニウム・炭酸水素ナトリウム共沈物、アルミニウムグリシネート及び水酸化アルミニウムゲルからなる群から選ばれた少なくとも一つの化合物である難溶性多価金属化合物
Ｂ：ヒドロキシ酸及び水。The following A and B components are mixed at 30 ° C. or lower, and the pH is set to 4 to 6 at low temperature cross-linked gel base:
A: at least one selected from the group consisting of ethanol and / or isopropanol, polyacrylic acid and / or salts thereof, and magnesium hydroxide alumina, aluminum hydroxide / sodium bicarbonate coprecipitate, aluminum glycinate and aluminum hydroxide gel Poorly soluble polyvalent metal compound B: hydroxy acid and water.
Ａ：エタノール及び／又はイソプロパノール、ポリアクリル酸及び／又はその塩類並びに水酸化アルミナマグネシウム、水酸化アルミニウム・炭酸水素ナトリウム共沈物、アルミニウムグリシネート及び水酸化アルミニウムゲルからなる群から選ばれた少なくとも一つの化合物である難溶性多価金属化合物
Ｂ：ヒドロキシ酸及び水。The following A and B components are mixed at 30 ° C. or lower, and the active ingredient-containing or non-containing low-temperature cross-linked gel preparation having a pH of 4 to 6:
A: at least one selected from the group consisting of ethanol and / or isopropanol, polyacrylic acid and / or salts thereof, and magnesium hydroxide alumina, aluminum hydroxide / sodium bicarbonate coprecipitate, aluminum glycinate and aluminum hydroxide gel Poorly soluble polyvalent metal compound B: hydroxy acid and water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP19055093A JP3739100B2 (en) | 1993-07-30 | 1993-07-30 | Low temperature crosslinking gel |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP19055093A JP3739100B2 (en) | 1993-07-30 | 1993-07-30 | Low temperature crosslinking gel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0739748A JPH0739748A (en) | 1995-02-10 |
| JP3739100B2 true JP3739100B2 (en) | 2006-01-25 |
Family
ID=16259948
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP19055093A Expired - Fee Related JP3739100B2 (en) | 1993-07-30 | 1993-07-30 | Low temperature crosslinking gel |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3739100B2 (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10959933B1 (en) | 2020-06-01 | 2021-03-30 | The Procter & Gamble Company | Low pH skin care composition and methods of using the same |
| US11110049B2 (en) | 2017-06-23 | 2021-09-07 | The Procter & Gamble Company | Composition and method for improving the appearance of skin |
| US11583488B2 (en) | 2020-06-01 | 2023-02-21 | The Procter & Gamble Company | Method of improving penetration of a vitamin B3 compound into skin |
| US11622963B2 (en) | 2018-07-03 | 2023-04-11 | The Procter & Gamble Company | Method of treating a skin condition |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6224899B1 (en) | 1997-03-18 | 2001-05-01 | Kobayashi Pharmaceutical Co., Ltd. | Adhesive cooling composition and process for its preparation |
| BR9804870A (en) | 1997-05-02 | 1999-08-24 | Gist Brocades Bv | Stable Vitamin C Concentrates |
| EP1491185B1 (en) * | 2002-03-14 | 2009-05-27 | Medrx Co., Ltd. | External medicine for wounds |
| ATE391744T1 (en) | 2002-06-19 | 2008-04-15 | Showa Denko Kk | AQUEOUS GEL AND PRODUCTION METHOD AND USE OF AQUEOUS GEL |
| JP4693340B2 (en) * | 2002-06-19 | 2011-06-01 | 昭和電工株式会社 | Hydrous gel body, method for producing the hydrogel body, and use thereof |
| CN1784204A (en) * | 2003-05-28 | 2006-06-07 | 味之素株式会社 | Oily gel composition |
| JP5999875B2 (en) * | 2011-03-30 | 2016-09-28 | 小林製薬株式会社 | Gel-like pharmaceutical composition |
| US9855211B2 (en) | 2013-02-28 | 2018-01-02 | Novan, Inc. | Topical compositions and methods of using the same |
| US11813284B2 (en) | 2013-08-08 | 2023-11-14 | Novan, Inc. | Topical compositions and methods of using the same |
| BR112017000456B1 (en) | 2014-07-11 | 2022-12-13 | Novan, Inc | USE OF A NITRIC OXIDE-RELEASING ACTIVE PHARMACEUTICAL INGREDIENT AND TOPICAL COMPOSITION FOR TREATMENT AND/OR PREVENTION OF A VIRAL INFECTION |
| US10322082B2 (en) | 2014-07-11 | 2019-06-18 | Novan, Inc. | Topical antiviral compositions and methods of using the same |
| EP3177262A4 (en) | 2014-08-08 | 2018-04-18 | Novan Inc. | Topical emulsions |
| US10912743B2 (en) | 2016-03-02 | 2021-02-09 | Novan, Inc. | Compositions for treating inflammation and methods of treating the same |
| BR112018070578A2 (en) | 2016-04-13 | 2019-02-12 | Novan, Inc. | compositions, systems, kits, and methods for treating an infection |
| CN114314777A (en) * | 2021-12-30 | 2022-04-12 | 浙江海拓环境技术有限公司 | Magnetic microsphere embedded with heavy metal capture agent, and preparation method and application thereof |
| CN117338698A (en) * | 2023-11-02 | 2024-01-05 | 中国牧工商集团有限公司 | Compound lidocaine gel and preparation method thereof |
-
1993
- 1993-07-30 JP JP19055093A patent/JP3739100B2/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11110049B2 (en) | 2017-06-23 | 2021-09-07 | The Procter & Gamble Company | Composition and method for improving the appearance of skin |
| US11622963B2 (en) | 2018-07-03 | 2023-04-11 | The Procter & Gamble Company | Method of treating a skin condition |
| US10959933B1 (en) | 2020-06-01 | 2021-03-30 | The Procter & Gamble Company | Low pH skin care composition and methods of using the same |
| US11583488B2 (en) | 2020-06-01 | 2023-02-21 | The Procter & Gamble Company | Method of improving penetration of a vitamin B3 compound into skin |
| US11911498B2 (en) | 2020-06-01 | 2024-02-27 | The Procter & Gamble Company | Low pH skin care composition and methods of using the same |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0739748A (en) | 1995-02-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP3739100B2 (en) | Low temperature crosslinking gel | |
| DE4020144C2 (en) | ||
| CN102939075A (en) | Transdermal absorption promoter, and external skin formulation thereof | |
| JP2012140460A (en) | Composition for hydrous adhesive patch for external use and adhesive patch comprising the composition | |
| JP2004524327A (en) | Topical patch containing delayed-type hypersensitivity inducer and method of using the patch | |
| JP3466305B2 (en) | Dissolving agent and external preparation containing the dissolving agent | |
| US20060079640A1 (en) | Adhesive composition for dermal patch and production process thereof | |
| WO2005102306A1 (en) | Anti-inflammatory analgesic adhesive patch | |
| JPH05201879A (en) | Percutaneous administration pharmaceutical | |
| WO2004024155A1 (en) | Adhesive patch | |
| JPS60199832A (en) | Antioxidative pharmaceutical preparation for external use | |
| WO2001043736A1 (en) | Drugs for relieving hemicrania | |
| WO2000001384A1 (en) | Ketotifen preparation for percutaneous absorption | |
| JP5175041B2 (en) | Hydrophilic adhesive, hydrophilic external skin adhesive composition and hydrophilic patch using the same | |
| JP4786196B2 (en) | Gel composition and method for producing the same | |
| US9254325B2 (en) | Percutaneously absorbed preparation | |
| JP4194277B2 (en) | Method for producing pressure-sensitive adhesive molded body mainly composed of crosslinked polymer | |
| EP1854456A1 (en) | Pressure-sensitive adhesive base and medical adhesive patch including the pressure-sensitive adhesive base | |
| JPH05310598A (en) | Agent for percutaneous administration | |
| JPH06135828A (en) | Percutaneous absorption preparation | |
| JPH078784B2 (en) | Hydrophilic transdermal preparation | |
| JPH09208469A (en) | Percutaneous absorption pasting agent | |
| JP4567998B2 (en) | Hydrophilic external skin pressure-sensitive adhesive composition and hydrophilic patch using hydrophilic pressure-sensitive adhesive | |
| JP3612731B2 (en) | Anti-inflammatory analgesic topical | |
| JPH03148218A (en) | Colchicine-containing external preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20050801 |
|
| A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20050908 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20050930 |
|
| A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20051004 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20051101 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20051101 |
|
| R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20081111 Year of fee payment: 3 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20111111 Year of fee payment: 6 |
|
| LAPS | Cancellation because of no payment of annual fees |