JP3455856B2 - Magnetic detector - Google Patents

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention is used for a brain evoked potential test or the like, and is for measuring the magnetic flux density of a magnetic stimulation pulse to a stimulation site in a subject when performing magnetic stimulation and the electric field strength thereof. The present invention relates to a magnetic stimulus detection device.

[0002]

2. Description of the Related Art Conventionally, this type of magnetic stimulator non-invasively magnetically stimulates the cerebrum and peripheral nerves of a subject and detects a potential change induced by this magnetic stimulus. The detected potential change is observed with a monitor scope or the like, and clinically effective information is obtained from the measurement result.

This magnetic stimulator comprises a stimulation coil for magnetically stimulating the cerebrum and peripheral nerves of a subject non-invasively, and a magnetic stimulation pulse generator to which the stimulation coil is connected.

When detecting a potential change induced in a living body by using the magnetic stimulating device having this structure, a width of 100 to 300 μs is applied to the stimulating coil from the magnetic stimulating pulse generating device.
And a pulse having a voltage of 500 V to 800 V is applied. By this application, the magnetic flux generated from the stimulation coil generates an eddy current in the conductive substance inside the living body. This eddy current stimulates the nerve and is conducted to various sides of the living body. For example, when the cerebrum is magnetically stimulated, the evoked potential transmitted to the ulnar nerve or the median nerve of the palm is detected through electrodes and observed with a monitor scope or the like.

[0005]

In the conventional magnetic stimulator as described above, in order to perform accurate measurement and analysis,
The amount of magnetic flux to the stimulation site of the subject was measured. Further, when the magnetic flux density from the stimulation coil to the stimulation site is high, the stimulation intensity is high, and the stimulation frequency is high, damage to the stimulation site is considered, and damage to the stimulation site in animal experiments has been reported. Therefore, in order to safely perform magnetic stimulation, it is necessary to accurately measure the strength of magnetic stimulation.
At present, only the output voltage of the stimulation coil is monitored from the magnetic stimulation device, and no particular measurement is performed on the intensity of the magnetic stimulation at the actual measurement site.

The present invention solves the above-mentioned drawbacks in the prior art, and when performing magnetic stimulation, the magnetic flux density of the magnetic stimulation pulse with respect to the stimulation site of the subject is made by a simple structure with no power supply. And a magnetic stimulus detection device capable of accurately measuring the electric field strength thereof.

[0007]

In order to achieve the above object, the invention according to claim 1 applies magnetic stimulation to a subject.
In front of a magnetic stimulator with a stimulation coil used for
For the magnetic detection device that detects the magnetism generated from the stimulation coil
In addition, a thin insulating substrate, a one-turn magnetic flux detecting coil arranged on one surface of the insulating substrate, and two insulating wires are twisted and connected to the one-turn magnetic flux detecting coil at each end. The one-turn magnetic flux detecting coil is formed in a circular shape between both ends thereof and is closely twisted to such a degree that magnetic flux detection by the two insulated wires is prevented. It is characterized by

The invention according to claim 2 provides a magnetic stimulation to a subject.
Stimulation with a stimulation coil used to give
A magnetic detector for detecting the magnetism emanating from the stimulation coil of the device.
In the output device, a thin insulating substrate, a one-turn magnetic flux detecting coil arranged on one surface of the insulating substrate, and
Shows the length of the one-turn magnetic flux detection coil from the center on the insulating substrate, and the lead wire which is connected to both ends of the one-turn magnetic flux detection coil one by one to lead out the induced voltage. And a scale.

The invention according to claim 3 provides a magnetic stimulation to a subject.
Center-directed stimulation coil used to give
In a magnetic detection device for detecting the magnetism emitted from the stimulation coil of a magnetic stimulation device having , a thin insulating substrate,
A one-turn magnetic flux detecting coil arranged on one surface of the insulating substrate; and a lead wire for twisting two insulating wires and connecting one to each end of the one-turn magnetic flux detecting coil to derive the induced voltage. A through hole penetrating the insulating substrate is provided at the center of the one-turn magnetic flux detecting coil.

The invention according to claim 4 provides a magnetic stimulation to a subject.
Center-directed stimulation coil used to give
In a magnetic detection device for detecting the magnetism emitted from the stimulation coil of a magnetic stimulation device having , a thin insulating substrate,
A plurality of one-turn magnetic flux detection coils arranged on one surface of the insulating substrate and two one-turn magnetic flux detection coils connected to both ends of the one-turn magnetic flux detection coils so as to derive induced voltages of the plurality of one-turn magnetic flux detection coils. A plurality of lead wires twisted together, and a through-hole penetrating the insulating substrate at the center of each one-turn magnetic flux detecting coil.

The invention according to claim 5 provides a magnetic stimulation to a subject.
Stimulation with a stimulation coil used to give
A magnetic detector for detecting the magnetism emanating from the stimulation coil of the device.
In the output device, a thin insulating substrate and one-turn magnetic flux detecting coils are concentrically provided on both sides of the insulating substrate, and one end of one one-turn magnetic flux detecting coil and one end of the other one-turn magnetic flux detecting coil are the same. It is equipped with a two-turn magnetic flux detection coil formed by connecting with a connecting wire so as to be in the winding direction, and a lead wire formed by twisting two insulated wires for deriving an induced voltage is connected to both ends of this two-turn magnetic flux detection coil. It is characterized by doing.

The invention according to claim 6 provides a magnetic stimulation to a subject.
Stimulation with a stimulation coil used to give
A magnetic detector for detecting the magnetism emanating from the stimulation coil of the device.
In the output device, a thin insulating substrate, a one-turn magnetic flux detecting coil arranged on one surface of the insulating substrate, and
Two insulated wires are twisted together and connected one by one to both ends of the one-turn magnetic flux detection coil, and a lead wire for deriving the induced voltage and a non-power source composed of a resistor and a capacitor are operated and led from the lead wire. Integrating means for outputting the integrated voltage indicating the magnetic flux density by time-integrating the induced voltage.

The invention according to claim 7 provides a magnetic stimulation to a subject.
Stimulation with a stimulation coil used to give
A magnetic detector for detecting the magnetism emanating from the stimulation coil of the device.
In the output device, a thin insulating substrate, a one-turn magnetic flux detecting coil arranged on one surface of the insulating substrate, and
A pair of insulated wires are twisted together and connected to both ends of the one-turn magnetic flux detection coil one by one to lead the induced voltage and a resistor. It is characterized by including a voltage dividing means for dividing the induced voltage and outputting a divided voltage indicating the electric field strength.

The invention according to claim 8 is the invention according to claim 6 or 7.
In addition to the configuration described above, the internal resistance of the coil connected in parallel to the input end of the integrating means or voltage dividing means to which the two lead wires for deriving the induced voltage are connected, and to which the two lead wires are connected It is characterized in that a shunt resistor having a larger resistance value and a resistance value smaller than that of the resistor in the integrating means is connected.

[0015]

[0016]

[0017]

With this structure, in the magnetic detector of the present invention, the one-turn magnetic flux detecting coil arranged on the thin insulating substrate generates the induced voltage by detecting the pulse magnetic flux from the stimulation coil. This generated voltage is led out through a twisted lead wire. That is, the parasitic open area for the magnetic flux is reduced by the twisted lead wires, and the voltage induced only by the one-turn magnetic flux detection coil is derived.

Further, the distance between the stimulating coil and the one-turn magnetic flux detecting coil can be determined by the scale of the insulating substrate. In addition, the through-holes provided in the insulating substrate not only allow confirmation by looking through the measurement site, but also inhibit the generation of eddy currents when magnetic stimulation is performed in a volume conductor (for example, in water). Without this, proper stimulation is possible. Further, the magnetic stimulus from the stimulation coil is detected through the plurality of one-turn magnetic flux detection coils arranged on one surface of the insulating substrate, and the magnetic stimulus in a wide range of the subject is detected.

Further, the through hole of the insulating substrate in the central portion of the one-turn magnetic flux detecting coil makes it possible to identify the site of the subject when the magnetic flux is applied to the subject. Further, a high induced voltage is generated by the two-turn magnetic flux detection coil in which coils provided on both surfaces of the insulating substrate are connected in series. Furthermore, the integrated voltage indicating the magnetic flux density and the divided voltage indicating the electric field strength are obtained without a power source. In addition, the shunt resistor provided at the input end of the integrating means or the voltage dividing means that is the output end of the lead wire reduces the stray capacitance between the stimulation coil and the coil, and prevents the coupling due to the stray capacitance. Noise in the integrated voltage and the divided voltage is reduced.

As described above, the magnetic flux density of the magnetic stimulation pulse with respect to the stimulation site of the subject and the electric field strength thereof can be accurately measured by a simple structure without a power source when performing the magnetic stimulation.

[0021]

Embodiments of the magnetic stimulus detection apparatus of the present invention will be described in detail with reference to the drawings. FIG. 1 is a block diagram showing the whole of the first embodiment. In FIG. 1, this magnetic stimulus detection device is arranged in contact with the upper part of the head of the subject M, and has a width of 100 to 300 μs and a voltage of 500 V to, for example.
The stimulation coil 10 is arranged between the stimulation coil 10 and the magnetic stimulation site of the subject M, and the stimulation coil 10 receives the pulse Sp of 1000 V and generates a magnetic flux to apply magnetic stimulation to the cerebrum of the subject M. It has a pulse magnetic flux density detector 12 which derives a detection signal Sa, which is a voltage induced by the magnetic flux generated at 10, through a lead wire 11 in which two insulated wires are twisted together. The stimulation coil 10 is composed of a circular coil portion and a handle portion, and an orthogonal cross wire 10a is provided in the opening portion of the coil to clearly indicate the center point of the opening.

Further, in this magnetic stimulus detection device, the stimulus coil 10 has a width of 100 to 300 μs and a voltage of 500 V to 1.
It has a magnetic stimulation pulse generator 14 for sending a pulse Sp of 000 V and an integrator 16 for time-integrating the pulsed detection signal Sa and outputting an integrated voltage V1 indicating the magnetic flux density to a monitor scope or the like not shown. There is. Further, an attenuator 18 which outputs a divided voltage V2 obtained by dividing the pulse-shaped detection signal Sa to a monitor scope or the like not shown, and an ulnar nerve or a median nerve of the palm when the cerebrum of the subject M is magnetically stimulated by the stimulation coil 10. Electrodes 20a and 20b for detecting evoked potentials in nerves and sending them to conventional evoked potential testing devices for testing AEP (audible evoked potential), SEP (somatic evoked potential), VEP (visual evoked potential), etc. have.

A detection signal Sa from the pulse magnetic flux density detector 12 through the lead wire 11 is applied in parallel to the integrator 16, and a resistor Ro for shunting the output end of the pulse magnetic flux density detector 12 is built in. , A resistor Ri for outputting an integrated voltage V1 obtained by integrating the detection signal Sa, and a capacitor Ci.

The attenuator 18 detects the detection signal S supplied from the pulse magnetic flux density detector 12 through the lead wire 11.
Resistors R1 and R2 for outputting a divided voltage V2 obtained by dividing a
have.

Next, the pulse magnetic flux density detector 12 will be described in detail. FIG. 2 is a top view showing a detailed configuration of the pulse magnetic flux density detector 12 in FIG. In FIG. 2, the pulse magnetic flux density detector 12 has a width of about 200 μm obtained by etching a copper foil on a substrate 12a such as a glass epoxy material.
One-turn magnetic flux detection coil 12b which is formed in m and generates an induced voltage by detecting the magnetic flux generated in the stimulation coil 10.
And a through hole 12c provided in the center of the one-turn magnetic flux detection coil 12b on the substrate 12a for clearly indicating the position of the measurement site of the subject.

Further, the pulse magnetic flux density detector 12
Is connected to both ends of the one-turn magnetic flux detection coil 12b and is fixed on the substrate 12a.
It has a lead wire 12d in which two insulated wires are twisted together in order to reduce the parasitic opening area for the magnetic flux from 0 and prevent the magnetic flux from being detected by other than the one-turn magnetic flux detecting coil 12b. Further, it is formed by printing or the like in the longitudinal direction of the lower end of the substrate 12a in the figure, and is separated from the through-hole 12c when the stimulation coil 10 is moved on the pulse magnetic flux density detector 12, that is, away from the one-turn magnetic flux detection coil 12b. 1 has a scale 12e for knowing the distance, and a holder 12f integrally molded with resin or covered with a vinyl cap or the like for holding the fixed state of the lead wire 12d connected to the lead wire 11 in FIG. .

FIG. 3 is a pulse magnetic flux density detector 1 shown in FIG.
One-turn magnetic flux detection coil 12b and lead wire 12 in 2
It is a top view which shows the connection state with d. In this example, the substrate 12
One-turn magnetic flux detection coil 1 provided on one surface of a
A land 30 formed at one end of 2b is arranged on the surface opposite to the surface of the substrate on which the one-turn magnetic flux detecting coil 12b is arranged, and one of the insulated wires 32 of the lead wire 12d drawn through the through hole 31 is drawn. Are connected by soldering, etc.

A land 33a having a through hole is arranged at the other end on the right side of the one-turn magnetic flux detecting coil 12b in the drawing, and is connected to the land 33b provided on the substrate surface opposite to the land 33a by a through hole. . Further, the land 33b has a soldering portion 34, and the other insulating wire 36 in the lead wire 12d is attached to this soldering portion 34.
The leading wire of is connected by soldering or the like. With this configuration, the connecting portion between the one-turn magnetic flux detecting coil 12b and the lead wire 12d becomes stable and reliable.

Next, the operation and function of the configuration of the first embodiment will be described. In FIG. 1, a pulse Sp is applied to the stimulation coil 10 from the magnetic stimulation pulse generator 14.
Is sent. The stimulation coil 10 generates a magnetic flux based on the input pulse Sp to apply magnetic stimulation to the cerebrum of the subject M. This magnetic flux is detected by the one-turn magnetic flux detection coil 12b in the pulse magnetic flux density detector 12 arranged in close contact with the stimulation coil 10. That is, the induced voltage generated by detecting the magnetic flux is generated. The detection signal Sa which is this induced voltage is derived through the lead wire 11.

As described above, when the pulse magnetic flux density detector 12 is closely attached to the stimulation coil 10 to detect the magnetic flux generated by the stimulation coil 10, the measurement of the subject M is performed through the through hole 12c in the one-turn magnetic flux detection coil 12b. The parts can be easily matched. Further, by matching the intersection of the cross wire 10a of the stimulation coil 10 and the through hole 12c in the one-turn magnetic flux detection coil 12b, the stimulation coil 10 can be arranged in the one-turn magnetic flux detection coil 12b at a constant position for each measurement. Become. Further, when the stimulation coil 10 is separated from the one-turn magnetic flux detection coil 12b to perform magnetic stimulation, the stimulation coil 10
The distance of the stimulation coil 10 separated from the center position of the one-turn magnetic flux detection coil 12b can be easily found by reading the intersection of the cross wire 10a at the scale of the scale 12e.

The lead wire 11 connected to the one-turn magnetic flux detecting coil 12b is formed by twisting two insulated wires together.
This reduces the parasitic aperture area for the magnetic flux. That is, the voltage induced only by the one-turn magnetic flux detection coil 12b is derived, and the detection error is reduced. The detection signal Sa derived through the lead wire 11 is applied to the resistor R
It is applied in parallel to o. The resistor Ro shunts the output end of the pulse magnetic flux density detector 12 to reduce the stray capacitance between the stimulation coil 10 and the one-turn magnetic flux detection coil 12b. As a result, the stimulation coil 10 and the one-turn magnetic flux detection coil 12b are not coupled by the floating electrostatic capacitance, and the pulses Sp or the like applied to the stimulation coil 10 do not overlap with each other and noise is mixed in the integrated voltage V1 and the divided voltage V2. Will not do. Therefore, when observing the integrated voltage V1 and the divided voltage V2 with the monitor scope, the S / N (signal /
Noise) ratio is improved, and more accurate measurement becomes possible.
In this case, the value of the resistor Ro is larger than the conductor resistance value of the one-turn magnetic flux detecting coil 12b, and the integrator 16
The resistance value is set to be smaller than the internal resistor Ri.

The pulsed detection signal Sa is input to the integrator 16 through the resistor Ro, and the integrator 16 shows the magnetic flux density B obtained by time-integrating the detection signal Sa with the resistor Ri and the value of the capacitor Ci. Outputs integrated voltage V1 for observation with a monitor scope. The density of the magnetic flux generated by the stimulation coil 10 to which the pulse Sp is applied is a three-dimensional distribution having the maximum magnetic flux density near the inner diameter. When this magnetic flux is detected by the one-turn magnetic flux detecting coil 12b having a finite opening area in the pulse magnetic flux density detector 12, it is averaged. In this case, the sum of the magnetic flux densities that penetrate the opening area of the one-turn magnetic flux detecting coil 12b in the magnetic flux density distribution is calculated, and this is divided by the opening area of the one-turn magnetic flux detecting coil 12b, and the one-turn magnetic flux detecting coil 12b is placed. It is the magnetic flux density measured at the center position.

One-turn magnetic flux detection coil 1 having an opening area S
The voltage e induced when the magnetic flux density B is linked to 2b is expressed by the following equation (1). e = -d (BS) / dt (1)

The magnetic flux density B obtained by time-integrating this voltage e is expressed by the following equation (2).

[Equation 1]

Further, the time constant Ci.Ri
(Resistor Ri and capacitor Ci in integrator 16 in FIG. 1), the integrated voltage V1 output from integrator 16
Can be expressed by the following equation (3).

[Equation 2]

From equations (2) and (3), the magnetic flux density B is represented by the following equation (4) by the integrated voltage V1.

[Equation 3]

The integrated voltage V1 is observed and measured by a monitor scope (not shown). For example, the time axis of the monitor scope is set to 0.5 ms / Div, and processing is performed with a delay of 2 Div. The sensitivity is set to 500 μv / Div to 5 mv / Div, and the filter is preferably 0.05 Hz to 10 kHz.

Further, the attenuator 18 divides the detection signal Sa supplied from the pulse magnetic flux density detector 12 through the lead wire 11 by the resistors R1 and R2, and the divided voltage V
Observe 2 with a monitor scope (not shown). This is because the magnetic flux Φ generated from the stimulation coil 10 generates an eddy current in a conductive substance inside the living body, and this eddy current stimulates nerves and is conducted to each side of the living body. To know.

This divided voltage V2 is expressed by the following equation (5). V2 = k (dΦ / dt) (5)

This divided voltage V2 is also observed by the monitor scope, like the integrated voltage V1. In this way, the integrated voltage V
From 1, the magnetic stimulation amount to the cerebrum of subject M will be known. Further, the change of the magnetic flux from the divided voltage V2 to the cerebrum of the subject M is also found.

The evoked potentials in the ulnar nerve or median nerve of the palm when the cerebrum of the subject M is magnetically stimulated by the stimulation coil 10 are detected by the electrodes 20a, 20b. The evoked potential due to the magnetic stimulation from the electrodes 20a and 20b is
It is measured with a conventional evoked potential test device. This measurement is the same inspection method as well-known AEP (audible evoked potential), SEP (somatic evoked potential), VEP (visual evoked potential) and the like.

Next, the second embodiment will be described. Figure 4
FIG. 7 is a top view showing the configuration of a pulse magnetic flux density detector in the second embodiment. In FIG. 4, the pulse magnetic flux density detector 40 is a one-turn magnetic flux detecting coil 40b that detects a magnetic flux generated in the stimulation coil 10 by forming a copper foil on a substrate 40a such as a glass epoxy material by etching.
And a through-hole 40c that is provided in the central substrate 40a of the one-turn magnetic flux detection coil 40b and that clearly indicates the position of the measurement site of the subject.

Further, the pulse magnetic flux density detector 40 is provided in the one-turn magnetic flux detecting coil 40b and around the through hole 40c, and is used for looking into the measurement site of the subject or when magnetic stimulation is performed in the volume conductor. The four windows 41a, 41b, 41c, 41d for enabling appropriate stimulation without hindering the generation of eddy currents and the both ends of the one-turn magnetic flux detection coil 40b are connected from the stimulation coil 10 when broken. In order to reduce the parasitic opening area for the magnetic flux and prevent the magnetic flux from being detected by other than the one-turn magnetic flux detecting coil 40b, a lead wire 42 formed by twisting two insulated wires together.
And a holder 43 that covers the projecting portion of the substrate 40a with resin integral molding or a vinyl cap or the like in order to maintain the fixed state of the lead wire 42. In this structure, the connection between both ends of the one-turn magnetic flux detection coil 40b and the lead wire 42 is the same as the connection structure shown in FIG.

The operation of this pulse magnetic flux density detector 40 is as follows.
Although it is similar to the pulse magnetic flux density detector 12 shown in FIG. 2, the stimulation site of the subject can be seen when performing magnetic stimulation through the windows 41a to 41d. As a result, the site at which magnetic stimulation is performed, for example, the conduction direction of the nerve that gives the magnetic flux is accurately identified.

Further, a third embodiment will be described. FIG. 5 is a top view showing the configuration of the pulse magnetic flux density detector 50 in the third embodiment. This pulse magnetic flux density detector 5
0 is formed by etching a copper foil on a horizontally long substrate 50a such as a glass epoxy material, detects the magnetic flux generated in the stimulation coil 10, and four one-turn magnetic flux detection coils 51a, 52a arranged in a straight line. , 53a, 54a
And through-holes 51b, 52b, which are provided in the substrate 50a in the central portions of the one-turn magnetic flux detection coils 51a to 54a and which clearly indicate the position of the measurement site of the subject.
It has 53b and 54b.

Further, in the pulse magnetic flux density detector 50, the parasitic opening area for the magnetic flux from the stimulation coil 10 connected to both ends of the one-turn magnetic flux detecting coils 51a to 54a is reduced, and the one-turn magnetic flux detecting coil 51a is reduced. To lead wires 51c, 52c, 5 in which two insulated wires are twisted in order to prevent the detection of magnetic flux other than 54a.
3c and 54c, and a holder 55 that covers the protruding portion of the substrate 50a with resin integral molding or a vinyl cap or the like in order to maintain the fixed state of the lead wires 51c to 54c. In this configuration, the connection between the respective ends of the one-turn magnetic flux detection coils 51a to 54a and the lead wires 51c to 54c is the same as the connection structure shown in FIG.

This pulse magnetic flux density detector 50 has four one-turn magnetic flux detecting coils 51a arranged in a straight line.
54a, it becomes possible to measure four measurement sites in the subject with one detector. For example, the pulse magnetic flux density detector 1 shown in FIG.
The pulse magnetic flux density detector 40 shown in FIG. 2 or FIG. 4 magnetically stimulates and measures a large number of sites in the subject while shifting the position.
Then, since it is possible to measure the magnetic flux density of the magnetic stimulation pulse and the electric field strength of the magnetic stimulation pulses at four nearby regions at once, the measurement time can be shortened.

Further, the fourth embodiment will be described. FIG. 6 is a top view showing the configuration of the pulse magnetic flux density detector in the fourth embodiment. In FIG. 6, this pulse magnetic flux density detector 60 includes pulse magnetic flux density detectors 12, 40, 5
In contrast to the case where 0 uses the one-turn magnetic flux detection coil for detecting the magnetic flux, the two-turn magnetic flux detection coil is used.

In this example, a substrate 62 such as a glass epoxy material is used.
The one-turn magnetic flux detection coils 63a and 63b for detecting the magnetic flux generated in the stimulation coil 10 and the one-turn magnetic flux detection coils 63a and 63b formed in the center of the one-turn magnetic flux detection coils 63a and 63b are formed so as to face the same portion on both sides of a. The substrate 62a has a through hole 64 for clearly indicating the position of the measurement site of the subject.

Further, this pulse magnetic flux density detector 60 forms a two-turn magnetic flux detecting coil by spirally connecting the one-turn magnetic flux detecting coils 63a and 63b, and also has a lead wire 65 in which two insulated wires are twisted together. It has a connected connection. This connecting portion has a rectangular through hole 66 provided between both ends of the one-turn magnetic flux detecting coils 63a and 63b, and one end of the one-turn magnetic flux detecting coil 63a on the right side in the drawing, which is inserted through the through hole 66. A jumper wire 67 for connecting the other end of the one-turn magnetic flux detection coil 63b on the left side in the drawing to form a two-turn magnetic flux detection coil spirally connected.

Further, this connecting portion is connected to one end on the left side of the one-turn magnetic flux detecting coil 63a in the figure and the leading end of one insulating wire 65a of the lead wire 65, and the leading end of the other insulating wire 65b of the lead wire 65. Conductor is through hole 6
6 is inserted and connected to the other end of the one-turn magnetic flux detection coil 63b on the right side in the drawing.

In the pulse magnetic flux density detector 60, the one-turn magnetic flux detecting coils 63a and 63b are connected by a jumper wire 67 to form a two-turn magnetic flux detecting coil. Then, with this two-turn magnetic flux detection coil, the stimulation coil 10
The induced voltage due to the magnetism generated at is derived as the detection signal. In this case, since a high induced voltage is obtained, S /
The N ratio is improved, and the magnetic flux density of the magnetic stimulation pulse and the electric field strength thereof can be measured with high accuracy.

If the pulse magnetic flux density detector 60 of the two-turn magnetic flux detecting coil shown in FIG. 6 is applied to the pulse magnetic flux density detectors 12, 40 and 50, it is possible to obtain high induced voltage in addition to the respective advantages. Is obtained, the S / N ratio is further improved, and the magnetic flux density of the magnetic stimulation pulse and the electric field strength thereof can be measured with higher accuracy.

[0054]

As is apparent from the above description, in the magnetic detector of the present invention, the one-turn magnetic flux detection coil generates an induced voltage by detecting the pulse magnetic flux from the stimulation coil,
It is led out through twisted lead wires. In this case, the magnetic stimulation site can be easily identified by the scale, the through hole, and the plurality of one-turn magnetic flux detection coils, and the magnetic stimulation can be easily performed on the plurality of sites. Furthermore, the window provided inside the one-turn magnetic flux detection coil enables appropriate stimulation without disturbing the generation of eddy currents even when magnetic stimulation is performed in a volume conductor or the like. Moreover, a high induced voltage is generated by the two-turn magnetic flux detection coil, and the magnetic flux density of the magnetic stimulation pulse and the integrated voltage and divided voltage indicating the electric field strength thereof are obtained without a power source. Further, the shunt resistor reduces the stray capacitance and reduces noise in the integrated voltage and the divided voltage.

As a result, the magnetic flux density of the magnetic stimulation pulse and the electric field strength of the magnetic stimulation pulse with respect to the stimulation site of the subject can be accurately measured with a simple structure without a power source when performing magnetic stimulation. Have.

[Brief description of drawings]

FIG. 1 is a configuration diagram showing an entire first embodiment of a magnetic stimulus detection apparatus of the present invention.

FIG. 2 is a top view showing a detailed configuration of a pulse magnetic flux density detector in FIG.

FIG. 3 is a top view showing a connection state between a one-turn magnetic flux detection coil and a lead wire in the pulse magnetic flux density detector shown in FIG.

FIG. 4 is a top view showing a configuration of a pulse magnetic flux density detector according to a second embodiment.

FIG. 5 is a top view showing a configuration of a pulse magnetic flux density detector according to a third embodiment.

FIG. 6 is a top view showing a configuration of a pulse magnetic flux density detector according to a fourth embodiment.

[Explanation of symbols]

10 stimulation coil 10a cross wire 11 lead wire 12 pulse magnetic flux density detector 12b One-turn magnetic flux detection coil 12c through hole 12d lead wire 12e scale 14 Magnetic stimulation pulse generator 16 integrator 18 Attenuator

Claims (8)

(57) [Claims] 1. A method for applying magnetic stimulation to a subject.
Of said stimulation coil of a magnetic stimulation device having a stimulation coil
In a magnetic detection device for detecting the magnetism generated from a thin insulating substrate, a one-turn magnetic flux detection coil arranged on one surface of the insulating substrate, and two insulating wires are twisted together to form one end of the one-turn magnetic flux detection coil. And a lead wire that is connected to each part to derive the induced voltage, and the one-turn magnetic flux detection coil is formed in a circular shape between both ends thereof, and the magnetic flux detection by the two insulated wires is performed. The magnetic detection device is characterized in that it is tightly twisted to such an extent that it prevents the magnetic field. 2. A method for applying magnetic stimulation to a subject.
Of said stimulation coil of a magnetic stimulation device having a stimulation coil
In a magnetic detection device for detecting the magnetism generated from a thin insulating substrate, a one-turn magnetic flux detection coil arranged on one surface of the insulating substrate, and two insulating wires are twisted together to form one end of the one-turn magnetic flux detection coil. A magnetic detection device comprising: a lead wire connected to each of the parts to derive the induced voltage; and a scale indicating a length from the center of the one-turn magnetic flux detection coil on the insulating substrate. 3. A method for applying magnetic stimulation to a subject.
Magnetic stimulation apparatus having a stimulating coil center is instructed to
In the magnetic detection device for detecting the magnetism generated from the stimulation coil , a thin insulating substrate, a one-turn magnetic flux detecting coil arranged on one surface of the insulating substrate, and two insulating wires are twisted together to form the one-turn magnetic flux. A magnetic detection device comprising: a lead wire connected to each of both ends of the detection coil to derive the induced voltage; and a through hole penetrating the insulating substrate at the center of the one-turn magnetic flux detection coil. 4. A method for applying magnetic stimulation to a subject.
Magnetic stimulation apparatus having a stimulating coil center is instructed to
In the magnetic detection device for detecting the magnetism emitted from the stimulation coil , a thin insulating substrate, a plurality of one-turn magnetic flux detection coils arranged on one surface of the insulating substrate, and a plurality of the one-turn magnetic flux detection coils, respectively. A plurality of lead wires twisted with two insulated wires, one connected to each end so as to derive the induced voltage of each, and the insulating substrate is pierced through the center of each one-turn magnetic flux detection coil. A magnetic detection device comprising: 5. A method for applying magnetic stimulation to a subject.
Of said stimulation coil of a magnetic stimulation device having a stimulation coil
In a magnetic detection device for detecting the magnetism generated from a thin insulating substrate, one-turn magnetic flux detection coils are concentrically provided on both sides of the insulating substrate, and one end of one one-turn magnetic flux detection coil and the other one-turn magnetic flux detection coil are detected. A two-turn magnetic flux detection coil is formed by connecting one end of the coil with a connecting wire so as to have the same winding direction. Two insulated wires for deriving the induced voltage are provided at both ends of the two-turn magnetic flux detection coil. A magnetic detection device characterized by connecting twisted lead wires. 6. A method for applying magnetic stimulation to a subject.
Of said stimulation coil of a magnetic stimulation device having a stimulation coil
In a magnetic detection device for detecting the magnetism generated from a thin insulating substrate, a one-turn magnetic flux detection coil arranged on one surface of the insulating substrate, and two insulating wires are twisted together to form one end of the one-turn magnetic flux detection coil. An integrated voltage indicating magnetic flux density by operating without a power supply consisting of a lead wire and a lead wire connected to each part to derive the induced voltage, and the induced voltage derived from the lead wire. A magnetic detection device comprising an integrating means for outputting 7. A method for applying magnetic stimulation to a subject.
Of said stimulation coil of a magnetic stimulation device having a stimulation coil
In a magnetic detection device for detecting the magnetism generated from a thin insulating substrate, a one-turn magnetic flux detection coil arranged on one surface of the insulating substrate, and two insulating wires are twisted together to form one end of the one-turn magnetic flux detection coil. It is composed of a resistor and a lead wire that is connected to each part to derive the above-mentioned induced voltage, and operates with no power supply. It divides the induced voltage derived from the lead wire and divides the divided voltage indicating the electric field strength. A magnetic detection device comprising a voltage dividing means for outputting. 8. In addition to the structure according to claim 6 or 7, in parallel with the input end of the integrating means or the voltage dividing means to which two lead wires for deriving the induced voltage are connected, and A magnetic detection device characterized in that a shunt resistor having a resistance value larger than the internal resistance of the coil to which the lead wire is connected and smaller than the resistor in the integrating means is connected.