JP3285452B2 - Toothpaste composition - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a dentifrice composition, and more particularly to a dentifrice composition which is effective in preventing dental caries and has stable properties over time.

[0002]

2. Description of the Related Art Hydroxyapatite is
To remove dental plaque which causes dental caries without damaging the tooth surface, promote remineralization of teeth and strengthen teeth (registered 1553266, JP-A-56-73014, registered 1557631),
It is also necessary to absorb and remove bad breath components in the oral cavity (Japanese Patent Laid-Open No.
[0315] It has been reported that the compound has various effects, such as the use in dentifrice compositions.

[0003] Hydroxyapatite reacts readily with other compounds, for example, if soluble fluoride is present in the composition at the same time, the fluoride ions are not allowed to act on the hydroxyapatite of the tooth enamel before they can act on the composition. It is known that it reacts with hydroxyapatite to form fluoroapatite, and is no longer a fluorine compound that works effectively. In order to overcome such a problem, for example, in Japanese Patent Application Laid-Open No. 2-31049, at least one of hydroxyapatite and fluoride is microencapsulated or coated to avoid direct contact with each other. In the same way, Japanese Patent Publication No. 6-8247
In this method, the hydroxy group present on the surface of hydroxyapatite is pretreated with a specific substance to avoid direct contact with each other and suppress the reaction with soluble fluoride. In JP-A-3-93726, the loss of effective fluoride is reduced by adjusting the pH of an oral composition containing hydroxyapatite and soluble fluoride to 7.0 to 11.0.

[0004]

However, dentifrices containing hydroxyapatite and soluble fluoride, if left for a long period of time, especially at high temperatures, or if a rapid temperature change occurs, may cause rough skin, and in severe cases, It was found that there was a problem that the feeling of use was significantly impaired due to solidification. This problem of solidification has not been addressed in the prior art at all, and cannot be solved, for example, by the method disclosed in Japanese Patent Application Laid-Open No. 3-93726, and the properties over time in toothpastes containing a mixture of hydroxyapatite and soluble fluoride And a solution for the appearance problem was needed.

[0005]

Means for Solving the Problems The inventors of the present invention have made intensive studies to solve such problems, and as a result, by including at least one selected from polyethylene glycol and vitamin E derivatives as a stabilizer. , Both hydroxyapatite and soluble fluoride are stably compounded,
Properties, appearance can obtain a stable dentifrice composition,
The present invention has been completed.

[0006] As the polyethylene glycol as a stabilizer used in the present invention, those having a degree of polymerization of 300 to 600 are suitable, and those having a degree of polymerization of less than 300 do not have sufficient water retention ability and exceed the degree of polymerization of 600. Since the solid is solid, it has poor compatibility with other components. The compounding amount is preferably 1 to 20%, and if the compounding amount is less than 1%, it is insufficient for stabilizing properties and appearance, and 20%
Beyond this, the usability will deteriorate. Further, the weight ratio of polyethylene glycol to hydroxyapatite is 1: 0.
A ratio of 5 to 1:50 is particularly preferred for stabilizing properties and appearance.

[0007] The vitamin E derivative which is a stabilizer used in the present invention is preferably tocopherol nicotinate or tocopherol acetate, particularly preferably tocopherol nicotinate. The compounding amount is 0.0
The content is preferably 1 to 1%, and if the amount is less than 0.01%, it is insufficient for stabilizing properties and appearance. Further, when the weight ratio of the vitamin E derivative to hydroxyapatite is 1: 1 to 1: 1000, it is particularly preferable for stabilizing properties and appearance.

[0008] As the soluble fluoride used in the present invention, sodium monofluorophosphate, sodium fluoride and tin fluoride are preferable.

The hydroxyapatite used in the present invention is variously selected, and among them, those having an average particle diameter of 1 to 50 μm, more preferably 3 to 30 μm are preferred. If the average particle diameter is less than 1 μm, the workability is poor, and if it exceeds 50 μm, the feeling of use is impaired. The content of hydroxyapatite is usually from 1 to 50%, more preferably from 3 to 10%. If it is less than 1%, the effect of hydroxyapatite is not observed, and
If it exceeds 0%, it is difficult to obtain good properties. Furthermore, the specific surface area of the hydroxyapatite used in the present invention is preferably 100 m ² / g or less and a specific surface area of 100 m ²
If it exceeds / g, the reactivity of hydroxyapatite becomes too high, and adversely affects the stabilization of properties and appearance.

The dentifrice composition of the present invention can be made into any form of toothpaste, liquid dentifrice or tablet according to a conventional method, and may be used as appropriate, if necessary, for example, an ordinary oral composition. Dibasic calcium phosphate,
Monobasic calcium phosphate, tribasic calcium phosphate, calcium carbonate, calcium pyrophosphate, aluminum hydroxide, alumina, silicic anhydride, silica gel, aluminum silicate, insoluble sodium metaphosphate, tribasic magnesium phosphate, magnesium carbonate, calcium sulfate, polymethacrylic acid Methyl, bentonite, zirconium silicate, synthetic resin, etc. are used.Sorbit, propylene glycol, concentrated glycerin, polyethylene glycol, etc. are used as wetting agents, and carboxymethylcellulose sodium, carrageenan, xanthan gum, sodium alginate are used as thickeners. Hydroxyethyl cellulose and the like are used, and as a surfactant, sodium lauryl sulfate, sodium lauroyl sarcosine, sucrose fatty acid ester, lauri Acid diethanolamide, polyoxyethylene hardened castor oil, polyoxyethylene-polyoxypropylene block copolymer or the like is used,
Other preservatives such as sodium benzoate and methyl paraben; essential oils such as peppermint and spearmint; fragrances such as fragrance materials such as l-menthol, carvone and anethole;
Saccharin sodium, stevioside, neohesperidyl dihydrochalcone, glycyrrhizin, thaumatin,
Perillartin, P-methoxycinnamic aldehyde,
Sweeteners such as xylitol, and cetylpyridinium chloride, chlorhexidine hydrochloride, triclosan, dextranase, mutanase, hinokitiol, lysozyme, allantoin, dipotassium glycyrrhizinate, epsilon aminocaproic acid, tranexamic acid, sodium chloride,
Active ingredients such as azulene and isopropylmethylphenol can be blended within a range that does not impair the effects of the present invention.

[0011]

The present invention will be described below in more detail with reference to Examples and Experimental Examples. Examples 1 to 15 and Comparative Example 1 Experiment Toothpastes shown in Table 1 were manufactured according to a standard method, and after each toothpaste was left at 55 ° C for 3 months, properties and feeling of use were evaluated according to the following evaluation criteria. (Evaluation criteria) ○: Good △: Somewhat problematic X: Problematic (Comprehensive evaluation) ◎: Both properties and feeling of use are ○ ○: Either property or feeling of use ×: Any of properties and feeling of use Is ×

[Table 1] As is clear from the results shown in Table 1, it can be seen that by containing one or more selected from polyethylene glycol having a specific polymerization degree and a vitamin E derivative, both properties and appearance are stable.

[0012]

[0013]

[0014]

[0015]

According to the present invention, a dentifrice composition which is effective in preventing dental caries and whose properties are stable over time can be obtained.

Claims (7)

(57) [Claims] 1. A dentifrice composition containing hydroxyapatite and a soluble fluoride, comprising polyethylene glycol and a vitamin E derivative as stabilizers. 2. The dentifrice composition according to claim 1, wherein the average particle size of the hydroxyapatite is 1 to 50 μm and the specific surface area is 100 m ² / g or less. 3. The dentifrice composition according to claim 1, wherein the weight ratio of the vitamin E derivative to hydroxyapatite is 1: 1 to 1: 1000. 4. The dentifrice composition according to claim 1, wherein the soluble fluoride is one or more of sodium monofluorophosphate, sodium fluoride and tin fluoride. 5. The dentifrice composition according to claim 1, wherein the vitamin E derivative is at least one selected from tocopherol nicotinate and tocopherol acetate. 6. The dentifrice composition according to claim 1, wherein the vitamin E derivative is tocopherol nicotinate. 7. The dentifrice composition according to claim 1, wherein the compounding amount of tocopherol nicotinate and tocopherol acetate is 0.01 to 1%.