JP3243387B2 - Plastic container containing bicarbonate-containing chemicals - Google Patents
Plastic container containing bicarbonate-containing chemicalsInfo
- Publication number
- JP3243387B2 JP3243387B2 JP33340794A JP33340794A JP3243387B2 JP 3243387 B2 JP3243387 B2 JP 3243387B2 JP 33340794 A JP33340794 A JP 33340794A JP 33340794 A JP33340794 A JP 33340794A JP 3243387 B2 JP3243387 B2 JP 3243387B2
- Authority
- JP
- Japan
- Prior art keywords
- oxygen
- packaging material
- bicarbonate
- space
- meq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Description
【０００１】[0001]
【産業上の利用分野】本発明は、炭酸水素塩を含有する
薬液入りプラスチック容器の収納体に関し、より詳しく
は前記包装材のガスバリアー性の低下を酸素検知剤の変
色を指標として、外観より容易に確認できるようにした
収納体に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a container for a plastic container containing a bicarbonate containing a chemical solution, and more particularly to a reduction in the gas barrier property of the above-mentioned packaging material, using the discoloration of an oxygen detector as an index. The present invention relates to a storage body that can be easily checked.
【０００２】[0002]
【従来の技術】従来から、炭酸水素ナトリウムなどの炭
酸水素塩を含有する薬液は、アシドーシスの是正などの
治療に広く用いられている。そして、前記薬液はガラス
製のアンプルやバイアルに充填され、市販されている。
一方、これまで輸液に用いられているプラスチック容器
は、ガスバリアー性が低く、炭酸水素塩を含有する薬液
を充填して放置すると、炭酸ガスが容器外に放出され、
水溶液中の炭酸水素イオン含量が低下し、それに伴いｐ
Ｈが上昇する等の問題点があった。そのため、炭酸水素
塩を含有する薬液を充填したプラスチック容器は実用化
されていなかった。最近、ガスバリアー性の高い包装材
でプラスチック容器を包装し、なおかつ、包装材と容器
との空間部を炭酸ガスで置換することで炭酸水素イオン
の安定性を向上させる方法が開示されている（特開平５
−４９６７５号公報、特開平５−２６１１４１号公報、
特開平６−１０５９０５号公報）。このようなガスバリ
アー性の高い包装材を利用しても、製造中、移送中など
の衝撃や接触により、包装材にピンホール等が発生した
場合、包装材のガスバリアー性の低下は避けられず、更
に包装材のガスバリアー性が低下すると、次第にプラス
チック容器内より炭酸ガスが放出されて、薬液中の炭酸
水素イオン含量が低下し、それに伴いｐＨが上昇する。
しかし、このような変化は収納体の外観からは確認でき
ないため、品質の劣化した薬液を誤って使用する危険性
がある。そして、前記薬液を使用した場合、期待した治
療効果が得られないとか、ｐＨの高い薬液を投与するこ
とによる副作用の発現などが懸念され、使用時に充分な
配慮が必要であった。2. Description of the Related Art Conventionally, a drug solution containing bicarbonate such as sodium bicarbonate has been widely used for treatment such as correction of acidosis. The chemical is filled in glass ampules or vials and is commercially available.
On the other hand, conventional plastic containers used for infusion have low gas barrier properties, and when filled with a chemical solution containing bicarbonate, carbon dioxide is released outside the container,
The bicarbonate ion content in the aqueous solution decreases,
There were problems such as an increase in H. Therefore, a plastic container filled with a chemical solution containing a bicarbonate has not been put to practical use. Recently, a method for improving the stability of hydrogen carbonate ions by packaging a plastic container with a packaging material having high gas barrier properties and replacing the space between the packaging material and the container with carbon dioxide gas has been disclosed ( JP 5
-49675, JP-A-5-261141,
JP-A-6-105905). Even if such a packaging material having a high gas barrier property is used, if a pinhole or the like occurs in the packaging material due to impact or contact during manufacturing, during transportation, etc., a decrease in the gas barrier property of the packaging material can be avoided. If the gas barrier property of the packaging material further decreases, carbon dioxide gas is gradually released from the plastic container, and the content of hydrogen carbonate ions in the chemical solution decreases, and the pH increases accordingly.
However, since such a change cannot be confirmed from the appearance of the storage body, there is a risk that a chemical solution of deteriorated quality may be used by mistake. When the above-mentioned drug solution is used, there is a concern that an expected therapeutic effect cannot be obtained or a side effect due to administration of the drug solution having a high pH is concerned.
【０００３】[0003]
【発明が解決しようとする課題】従って、このような品
質の劣化した薬液を誤って使用することがないように、
包装材のガスバリアー性を外観から容易に確認できる収
納体の開発が望まれていた。Therefore, in order to prevent the use of such a deteriorated chemical solution by mistake,
It has been desired to develop a storage body in which the gas barrier properties of the packaging material can be easily confirmed from the appearance.
【０００４】[0004]
【課題を解決するための手段】そこで、本発明者らは上
記課題を解決するために鋭意研究した結果、炭酸水素塩
を含有する薬液入りプラスチック容器をガスバリアー性
の高い包装材で包装した収納体において、前記容器と包
装材との空間部に脱酸素剤と酸素検知剤を収納し、かつ
前記空間部を炭酸ガスを含むガス雰囲気とした時に、包
装材のガスバリアー性が低下すると、収納体の空間部に
大気が入って酸素濃度が上昇し、酸素検知剤が変色して
包装材のガスバリアー性の低下が確認できることを見い
出し本発明を完成した。The inventors of the present invention have conducted intensive studies to solve the above-mentioned problems, and as a result, have found that a plastic container containing a bicarbonate-containing chemical solution is packaged in a packaging material having high gas barrier properties. In the body, when a deoxygenating agent and an oxygen detecting agent are stored in the space between the container and the packaging material, and when the space has a gas atmosphere containing carbon dioxide gas, if the gas barrier property of the packaging material is reduced, the storage is performed. The present invention has been completed by finding that the oxygen concentration rises due to the air entering the space inside the body, the oxygen detector discolors, and a decrease in the gas barrier property of the packaging material can be confirmed.
【０００５】すなわち、本発明は炭酸水素塩を含有する
薬液入りプラスチック容器がガスバリアー性の高い包装
材で包装された収納体において、前記容器と包装材との
空間部に脱酸素剤と酸素検知剤が収納され、かつ前記空
間部が炭酸ガスを含む実質的に酸素の存在しないガス雰
囲気とされている収納体を提供する。That is, the present invention relates to a container in which a plastic container containing a bicarbonate containing a chemical solution is packaged with a packaging material having a high gas barrier property, and a space between the container and the packaging material is provided with a deoxidizer and oxygen detector. The present invention provides a container in which an agent is stored, and the space has a gas atmosphere substantially free of oxygen containing carbon dioxide.
【０００６】本発明に使用される炭酸水素塩を含有する
薬液は、炭酸水素ナトリウム、炭酸水素カリウム等の炭
酸水素塩の単独の水溶液やこれらの混合液であってもよ
く、炭酸水素イオンの濃度としては通常０．０１〜１Ｍ
の濃度範囲である。更に炭酸水素塩以外の電解質を含む
ことも可能であるが、細胞外液タイプの輸液処方として
は、特に下記の電解質イオン組成範囲が望ましい。[0006] The chemical solution containing bicarbonate used in the present invention may be a single aqueous solution of bicarbonate such as sodium bicarbonate or potassium bicarbonate or a mixture thereof, and the concentration of bicarbonate ion may be increased. Is usually 0.01-1M
Is the concentration range. Further, although it is possible to include an electrolyte other than bicarbonate, the following electrolyte ion composition range is particularly desirable as an extracellular fluid type infusion formulation.
【０００７】 ナトリウムイオン １２０〜１５０ｍＥｑ／ｌ カリウムイオン ０〜 １０ｍＥｑ／ｌ カルシウムイオン ０〜 ５ｍＥｑ／ｌ マグネシウムイオン ０〜 ５ｍＥｑ／ｌ クエン酸イオン １〜 ５ｍＥｑ／ｌ 炭酸水素イオン ２０〜 ３５ｍＥｑ／ｌ また、必要に応じて上記組成の溶液に微量元素などの成
分を添加することも可能であり、その薬液のｐＨ範囲は
７．０〜７．８であるものが好ましい。Sodium ion 120 to 150 mEq / l Potassium ion 0 to 10 mEq / l Calcium ion 0 to 5 mEq / l Magnesium ion 0 to 5 mEq / l Citrate ion 1 to 5 mEq / l Bicarbonate ion 20 to 35 mEq / l It is also possible to add a component such as a trace element to the solution having the above composition according to the above, and the pH range of the chemical is preferably 7.0 to 7.8.
【０００８】前記電解質としては、薬理学的に許容され
るものであればいずれも使用できるが、例えば、炭酸水
素ナトリウム、炭酸水素カリウム、塩化ナトリウム、酢
酸ナトリウム、乳酸ナトリウム、クエン酸ナトリウム、
塩化カリウム、乳酸カリウム、クエン酸カリウム、酢酸
カリウム、クエン酸カルシウム、乳酸カルシウム、グリ
セロリン酸カルシウム、グルコン酸カルシウム等をあげ
ることができる。As the electrolyte, any pharmacologically acceptable electrolyte can be used. For example, sodium bicarbonate, potassium bicarbonate, sodium chloride, sodium acetate, sodium lactate, sodium citrate,
Examples include potassium chloride, potassium lactate, potassium citrate, potassium acetate, calcium citrate, calcium lactate, calcium glycerophosphate, calcium gluconate and the like.
【０００９】また本発明において、前記炭酸水素塩を含
有する薬液入りプラスチック容器をガスバリアー性の高
い包装材で包装して収納する際、脱酸素剤及び酸素検知
剤と共に少なくとも前記脱酸素剤及び酸素検知剤の周囲
に空間が存在するように収納するのが好ましい。その周
囲に空間が存在しないように包装すると、脱酸素剤の酸
素徐脱効果が悪くなり、酸素検知剤は空間部に残存する
酸素と速やかに反応して変色する。本発明において、前
記容器と包装材との空間部の酸素濃度が酸素検知剤の変
色域濃度以下、好ましくは０．５％以下にすることが必
要である。このための手段としては、炭酸ガスと不活性
ガスとの混合ガスで前記空間部を置換し、更に脱酸素剤
を併用する方法が有利である。この方法に用いられる不
活性ガスとしては、窒素ガスが好ましい。脱酸素剤とし
ては、前記容器と包装材との空間部の酸素を除去できる
ものであればいずれでもよいが、酸素吸収と同時に炭酸
ガスを放出する脱酸素剤を用いるのが好ましい。例えば
市販の三菱瓦斯化学（株）製（商品名：エージレスＧ）
等を用いることができる。In the present invention, when the plastic container containing a chemical solution containing a bicarbonate is packaged and housed in a packaging material having a high gas barrier property, at least the oxygen absorber and the oxygen detector are used together with at least the oxygen absorber and the oxygen detector. It is preferable to store the detection agent so that a space exists around the detection agent. If the package is packaged so that there is no space around it, the oxygen elimination effect of the oxygen scavenger deteriorates, and the oxygen detector quickly reacts with the oxygen remaining in the space to change its color. In the present invention, it is necessary that the oxygen concentration in the space between the container and the packaging material is not more than the discoloration region concentration of the oxygen detector, preferably not more than 0.5%. As a means for this purpose, a method in which the space is replaced with a mixed gas of carbon dioxide gas and an inert gas, and a deoxidizer is additionally used is advantageous. As the inert gas used in this method, nitrogen gas is preferable. Any oxygen scavenger can be used as long as it can remove oxygen in the space between the container and the packaging material, but it is preferable to use an oxygen scavenger that releases carbon dioxide simultaneously with oxygen absorption. For example, commercially available Mitsubishi Gas Chemical Co., Ltd. (trade name: Ageless G)
Etc. can be used.
【００１０】また、本発明に使用される酸素検知剤とし
ては、酸素のみに反応し、他のガスと反応しないもの、
例えば市販の三菱瓦斯化学（株）製（商品名：エージレ
スアイＣＳ）等を用いることができる。また酸素検知剤
を長期間に亙って使用する場合、炭酸ガス放出型の脱酸
素剤と併用することがより好ましい。The oxygen detector used in the present invention is one which reacts only with oxygen and does not react with other gases.
For example, commercially available Mitsubishi Gas Chemical Co., Ltd. (trade name: Ageless Eye CS) can be used. When the oxygen detector is used for a long period of time, it is more preferable to use the oxygen detector together with a carbon dioxide releasing type oxygen scavenger.
【００１１】このように脱酸素剤と併用した場合、前記
容器と包装材との空間部の酸素濃度が０．５％以下とな
るので、酸素検知剤の効力が維持され、包装材のガスバ
リアー性の低下を確認するために長期間に亙って利用で
きる。When the oxygen-absorbing agent is used in combination with the oxygen-absorbing agent, the oxygen concentration in the space between the container and the packaging material becomes 0.5% or less, so that the effectiveness of the oxygen detecting agent is maintained and the gas barrier of the packaging material is maintained. It can be used over a long period of time to check for a drop in sex.
【００１２】本発明に使用されるプラスチック容器とし
ては、従来使用されているポリエチレン、ポリプロピレ
ン、ポリ塩化ビニル等の材質からなるものを用いること
ができる。更に、ガスバリアー性の高い包装材料として
は、延伸ビニロン（ＯＶ）、エチレンビニルアルコール
共重合体（ＥＶＯＨ）、ポリエチレンテレフタレート
（ＰＥＴ）、ポリ塩化ビニリデン（ＰＶＤＣ）等の材質
のものやこれらの多層フィルムからなるものを用いるこ
とができ、酸素検知剤の変色が確認できる程度の透明性
を有することが望ましい。As the plastic container used in the present invention, those made of conventionally used materials such as polyethylene, polypropylene and polyvinyl chloride can be used. Further, packaging materials having high gas barrier properties include materials such as stretched vinylon (OV), ethylene vinyl alcohol copolymer (EVOH), polyethylene terephthalate (PET), and polyvinylidene chloride (PVDC), and multilayer films thereof. And it is desirable that the oxygen detector has such transparency that the discoloration of the oxygen detector can be confirmed.
【００１３】前記容器と包装材との空間部の炭酸ガス濃
度は、薬液の炭酸水素イオン濃度に合わせて炭酸ガスと
窒素ガスの混合比率を適宜設定することが炭酸水素イオ
ンの安定化に必要である。具体的には、炭酸水素イオン
濃度が２０〜３５ｍＥｑ／ｌの範囲にある場合は炭酸ガ
ス濃度を５〜２０％とすればよい。The concentration of carbon dioxide in the space between the container and the packaging material is required to stabilize bicarbonate ions by appropriately setting the mixing ratio of carbon dioxide and nitrogen gas in accordance with the concentration of hydrogen carbonate ions in the chemical solution. is there. Specifically, when the bicarbonate ion concentration is in the range of 20 to 35 mEq / l, the carbon dioxide gas concentration may be 5 to 20%.
【００１４】[0014]
【作用】このように本発明によれば、炭酸水素塩を含有
する薬液入りプラスチック容器が脱酸素剤及び酸素検知
剤と共にガスバリアー性の高い包装材に収納されてお
り、前記容器と包装材との空間部の酸素濃度が０．５％
以下となっている。このため、酸素検知剤の安定性が良
くなり、薬液の長期保存に適用できる。また、製造中、
移送中などの衝撃や接触により包装材にピンホール等が
発生し、包装材のガスバリアー性が低下すると、酸素検
知剤の変色が収納体の外観から容易に確認できる。即
ち、薬液の長期保存中に炭酸水素イオン含量が低下し、
それに伴ってｐＨが次第に上昇した劣化品を誤って使用
する心配がないので、期待した治療効果が得られないと
か、ｐＨの高い薬液を投与することによる副作用が発現
するなどの虞を回避でき、安全性の高い薬液を提供でき
る。従って、炭酸水素塩を含有する電解質輸液剤の場合
には、特に本発明を適用するのが効果的である。As described above, according to the present invention, a plastic container containing a chemical solution containing a bicarbonate is contained in a packaging material having a high gas barrier property together with a deoxidizer and an oxygen detector. Oxygen concentration in the space of 0.5%
It is as follows. For this reason, the stability of the oxygen detector is improved, and it can be applied to long-term storage of a chemical solution. Also during production,
When a pinhole or the like is generated in the packaging material due to an impact or contact during transportation or the like and the gas barrier property of the packaging material is reduced, the discoloration of the oxygen detector can be easily confirmed from the appearance of the container. That is, the bicarbonate ion content decreases during the long-term storage of the drug solution,
Since there is no risk of accidentally using a deteriorated product whose pH has gradually increased with it, it is possible to avoid the risk that the expected therapeutic effect is not obtained or that side effects due to administering a high pH drug solution are exhibited, A highly safe chemical solution can be provided. Accordingly, it is particularly effective to apply the present invention to an electrolyte infusion containing a bicarbonate.
【００１５】[0015]
【実施例】以下、実施例、試験例に基づいて本発明をよ
り詳細に説明するが、本発明はこれらに限定されるもの
ではない。EXAMPLES Hereinafter, the present invention will be described in more detail with reference to Examples and Test Examples, but the present invention is not limited to these.
【００１６】〔実施例１〕表１に示した各成分を常温で
蒸留水に溶解し、溶液中に炭酸ガスを吹き込んでｐＨを
６．８に調整後、この溶液を孔径０．２２μｍのメンブ
ランフィルターで濾過した。これをポリエチレン製のプ
ラスチック容器に５００ｍｌずつ充填し、常法にしたが
って高圧蒸気滅菌を行った。冷却後、前記薬液入りプラ
スチック容器を脱酸素剤（三菱瓦斯化学（株）製エージ
レスＧ）及び酸素検知剤（三菱瓦斯化学（株）製エージ
レスアイＣＳ）と共に包装材（エチレンビニルアルコー
ル共重合体、クラレ（株）製エバールなどからなる多層
フィルム）に収納し、包装材との空間部を炭酸ガスと窒
素ガスとの混合ガス（１５：８５）により置換し、ヒー
トシールで密封することにより炭酸水素塩含有薬液入り
プラスチック容器の収納体を製造した。Example 1 The components shown in Table 1 were dissolved in distilled water at room temperature, carbon dioxide gas was blown into the solution to adjust the pH to 6.8, and the solution was added to a membrane having a pore size of 0.22 μm. Filtered with a filter. This was filled into a polyethylene plastic container in an amount of 500 ml each, and subjected to high-pressure steam sterilization according to a conventional method. After cooling, the plastic container containing the chemical was packed with a deoxidizer (Ageless G manufactured by Mitsubishi Gas Chemical Co., Ltd.) and an oxygen detector (Ageless Eye CS manufactured by Mitsubishi Gas Chemical Co., Ltd.) in a packaging material (ethylene vinyl alcohol copolymer, It is housed in a multilayer film made of EVAL etc. manufactured by Kuraray Co., Ltd., and the space with the packaging material is replaced with a mixed gas of carbon dioxide gas and nitrogen gas (15:85), and sealed by heat sealing to form hydrogencarbonate. A container of a plastic container containing a salt-containing chemical solution was manufactured.
【００１７】[0017]
【表１】 [Table 1]
【００１８】〔実施例２〕炭酸水素ナトリウム７０．０
ｇを蒸留水に溶解し、全量を１０００ｍｌとした点を除
き、実施例１と同様に操作して炭酸水素塩含有薬液入り
プラスチック容器の収納体を製造した。Example 2 Sodium bicarbonate 70.0
g was dissolved in distilled water to prepare a plastic container containing a bicarbonate-containing chemical solution in the same manner as in Example 1 except that the total amount was 1000 ml.
【００１９】〔試験例１〕前記実施例１で製造した収納
体の包装材の表面に注射針（１８ゲージ）で１ヶ所穴を
あけた。そして、経時的に酸素検知剤の色の変化、薬液
のｐＨ、炭酸水素イオン含量及び収納体空間部の酸素濃
度を測定した。その結果を表２に示した。Test Example 1 One hole was made on the surface of the packaging material of the container manufactured in Example 1 with an injection needle (18 gauge). Then, the color change of the oxygen detecting agent, the pH of the chemical solution, the content of hydrogen carbonate ions, and the oxygen concentration in the space of the container were measured over time. The results are shown in Table 2.
【００２０】[0020]
【表２】 [Table 2]
【００２１】上記の結果から、包装材のガスバリアー性
の低下に伴い薬液のｐＨが大きく変化する前に、収納体
空間部の酸素濃度が上昇し、酸素検知剤の色が変化して
炭酸水素イオンの含量低下を確認することができた。ま
た、この変化を溶液の外観からは観察することができな
かった。From the above results, before the pH of the chemical solution greatly changes due to the decrease in the gas barrier property of the packaging material, the oxygen concentration in the storage space increases, the color of the oxygen detecting agent changes, and the hydrogen carbonate A decrease in the ion content could be confirmed. Further, this change could not be observed from the appearance of the solution.
【００２２】〔試験例２〕前記実施例１で製造した収納
体を４０℃で１カ月間保存した。また、評価は薬液のｐ
Ｈ、炭酸水素イオン含量及び収納体の空間部の炭酸ガス
濃度を測定して行った。その結果を表３に示した。Test Example 2 The container produced in Example 1 was stored at 40 ° C. for one month. In addition, the evaluation
The measurement was performed by measuring H, hydrogen carbonate ion content, and carbon dioxide gas concentration in the space of the container. Table 3 shows the results.
【００２３】[0023]
【表３】 [Table 3]
【００２４】上記の結果より、薬液のｐＨ、炭酸水素イ
オン含量及び収納体空間部の炭酸ガス濃度に大きな変化
はなく、また酸素検知剤の色にも変化は認められなかっ
た。従って、酸素検知剤が長期間の保存に対して安定で
あることが明らかとなった。From the above results, there was no significant change in the pH of the chemical solution, the content of hydrogen carbonate ions, and the concentration of carbon dioxide in the space of the container, and no change was found in the color of the oxygen detector. Therefore, it became clear that the oxygen detector was stable for long-term storage.
【００２５】[0025]
【発明の効果】以上のように、本発明によれば炭酸水素
塩を含有する薬液入りプラスチック容器の包装材のガス
バリアー性の低下が、酸素検知剤の変色を指標として確
認できるので、炭酸水素イオン含量が低下し、ｐＨが上
昇した薬液を誤って使用することが未然に防止できる。As described above, according to the present invention, a decrease in the gas barrier property of the packaging material of a plastic container containing a chemical solution containing a hydrogen carbonate can be confirmed by using the discoloration of the oxygen detector as an index. It is possible to prevent erroneous use of a chemical solution having a reduced ion content and an increased pH.
【図１】本発明の炭酸水素塩を含有する薬液入りプラス
チック容器の収納体の正面図である。FIG. 1 is a front view of a housing of a plastic container containing a bicarbonate solution of the present invention.
１ 炭酸水素塩を含有する薬液 ２ ガスバリアー性の高い包装材 ３ 酸素ガス検知剤 ４ 脱酸素剤 ５ プラスチック容器 ６ プラスチック容器２とガスバリアー性の高い包装材
３との空間部Reference Signs List 1 Chemical solution containing bicarbonate 2 Packaging material with high gas barrier property 3 Oxygen gas detector 4 Oxygen absorber 5 Plastic container 6 Space between plastic container 2 and packaging material 3 with high gas barrier property
───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.7 識別記号 ＦＩ //(Ａ６１Ｋ 33/10 Ａ６１Ｋ 31:19） 31:19） Ａ６１Ｊ 1/00 ３９０Ｓ (56)参考文献 特開 平５−49675（ＪＰ，Ａ) 特開 平６−105905（ＪＰ，Ａ) 特開 平５−261141（ＪＰ，Ａ) 特開 平５−237162（ＪＰ，Ａ) 特開 平６−335527（ＪＰ，Ａ) 特開 昭59−29033（ＪＰ，Ａ) 実開 昭59−34357（ＪＰ，Ｕ) 実開 昭58−102476（ＪＰ，Ｕ) (58)調査した分野(Int.Cl.7，ＤＢ名) A61J 1/14 A61J 3/00 300 A61K 31/19 A61K 33/10 B65D 81/26 ──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. 7 Identification symbol FI // (A61K 33/10 A61K 31:19) 31:19) A61J 1/00 390S (56) References JP-A-5-49675 JP-A-6-105905 (JP, A) JP-A-5-261141 (JP, A) JP-A-5-237162 (JP, A) JP-A-6-335527 (JP, A) Open Sho 59-29033 (JP, A) Open Sho 59-34357 (JP, U) Open Sho 58-102476 (JP, U) (58) Fields investigated (Int. Cl. 7 , DB name) A61J 1 / 14 A61J 3/00 300 A61K 31/19 A61K 33/10 B65D 81/26
Claims (4)
ック容器がガスバリアー性の高い包装材で包装された収
納体において、前記容器と包装材との空間部に炭酸ガス
放出型脱酸素剤と酸素の濃度に依存して変色する型の酸
素検知剤が収納され、かつ前記空間部が炭酸ガスを含む
実質的に酸素の存在しないガス雰囲気とされていること
を特徴とする収納体。1. A container in which a plastic container containing a chemical solution containing a bicarbonate is packaged with a packaging material having high gas barrier properties, wherein a space between the container and the packaging material is provided with a carbon dioxide releasing oxygen absorber and oxygen. A housing in which an oxygen detecting agent of a type that changes color depending on the concentration thereof is housed, and the space is a gas atmosphere containing carbon dioxide and substantially free of oxygen.
含有し、そのｐＨが７.０〜７.８であることを特徴とす
る請求項１に記載の収納体。 ナトリウムイオン １２０〜１５０ｍＥｑ／ｌ カリウムイオン ０〜 １０ｍＥｑ／ｌ カルシウムイオン ０〜 ５ｍＥｑ／ｌ マグネシウムイオン ０〜 ５ｍＥｑ／ｌ クエン酸イオン １〜 ５ｍＥｑ／ｌ 炭酸水素イオン ２０〜 ３５ｍＥｑ／ｌ2. The container according to claim 1, wherein the chemical solution contains the following components in the following composition range, and has a pH of 7.0 to 7.8. Sodium ion 120-150 mEq / l Potassium ion 0-10 mEq / l Calcium ion 0-5 mEq / l Magnesium ion 0-5 mEq / l Citrate ion 1-5 mEq / l Bicarbonate ion 20-35 mEq / l
空間部の炭酸ガス濃度が５〜２０％であることを特徴と
する請求項１又は２に記載の収納体。3. The container according to claim 1, wherein a carbon dioxide concentration in a space between the plastic container containing the chemical and the packaging material is 5 to 20%.
空間部の酸素濃度が０.５％以下であることを特徴とす
る請求項１〜３のいずれかに記載の収納体。4. The container according to claim 1, wherein the oxygen concentration in the space between the plastic container containing the chemical and the packaging material is 0.5% or less.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP33340794A JP3243387B2 (en) | 1994-12-14 | 1994-12-14 | Plastic container containing bicarbonate-containing chemicals |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP33340794A JP3243387B2 (en) | 1994-12-14 | 1994-12-14 | Plastic container containing bicarbonate-containing chemicals |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH08164185A JPH08164185A (en) | 1996-06-25 |
| JP3243387B2 true JP3243387B2 (en) | 2002-01-07 |
Family
ID=18265773
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP33340794A Expired - Lifetime JP3243387B2 (en) | 1994-12-14 | 1994-12-14 | Plastic container containing bicarbonate-containing chemicals |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3243387B2 (en) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2219768T3 (en) | 1996-06-17 | 2004-12-01 | Otsuka Pharmaceutical Factory, Inc. | PACKING FOR LIQUID MEDICINAL CONTAINER CONTAINING BICARBONATE. |
| AT408416B (en) * | 1996-07-19 | 2001-11-26 | Norbert Fuchs | PHARMACEUTICAL OR DIETETIC COMPOSITIONS |
| US5881879A (en) * | 1997-02-07 | 1999-03-16 | Baxter International Inc. | System for preserving and delivering gas-containing solutions |
| DE69831680T2 (en) * | 1997-04-10 | 2006-06-22 | The Johns Hopkins University | GAS-FILLED SYRINGE AND PACKAGING |
| JP3060133U (en) * | 1997-10-27 | 1999-07-30 | 株式会社大塚製薬工場 | Eye perfusion / wash bag package |
| JP2003254922A (en) * | 2002-02-28 | 2003-09-10 | Shimizu Pharmaceutical Co Ltd | Oxygen detector and its packing body |
| CN101426383A (en) * | 2006-02-28 | 2009-05-06 | 戴维·R·比曼 | Water formulation |
| JP4984033B2 (en) * | 2006-05-12 | 2012-07-25 | 味の素株式会社 | Container container filled with bicarbonate-containing chemicals |
| JP2008068900A (en) * | 2006-09-14 | 2008-03-27 | Toppan Printing Co Ltd | Package |
| GB0619060D0 (en) * | 2006-09-27 | 2006-11-08 | Glaxosmithkline Biolog Sa | Novel process |
| JP2008110793A (en) * | 2006-10-31 | 2008-05-15 | Toppan Printing Co Ltd | Secondary container having oxygen-absorbing ability |
| CN102614081A (en) * | 2012-04-20 | 2012-08-01 | 四川科伦药业股份有限公司 | Transfusion bag for accommodating sodium bicarbonate injection, and production method for transfusion bag |
| JP7375276B2 (en) * | 2019-07-12 | 2023-11-08 | Ｔｏｐｐａｎホールディングス株式会社 | Bicarbonate Ringer's solution infusion bag packaging bag |
-
1994
- 1994-12-14 JP JP33340794A patent/JP3243387B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH08164185A (en) | 1996-06-25 |
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