JP2795466B2 - Interface for iontophoresis - Google Patents

Description

The present invention relates to an interface (skin abutment) for iontophoresis.

The interface in iontophoresis has a structure in which a reservoir for holding a chemical solution and an electrode for current distribution are combined.

The structure of this reservoir must ensure that the drug solution reaches a predetermined amount over time up to the biological skin interface, but since the reservoir itself is three-dimensional and passes through water, dilution of the drug occurs. For example, a sufficient structure has not yet been proposed.

In view of the above, an object of the present invention is to provide an interface having a structure suitable for iontophoresis, that is, a structure capable of performing accurate and safe medication.

 The features of the present invention are as follows.

The present invention is one in which a solid or dry drug is applied to one surface of a porous material by coating, adhering, coating or the like, and in use, by applying electricity and supplying a carrier liquid from the other surface. Only at the time of use, the carrier liquid and the drug are mixed to form a local high-concentration drug solution, and the administration of the transdermal drug solution is promoted while maintaining the drug solution at a high concentration without being diffused and diluted by electric force.

Further, the present invention is suitable for long-term storage of a drug because the drug is in a solid state, that is, in a dry state before use.

Examples of the porous material include ceramics such as unfired, alumina, and zirconia, and synthetic resin materials. Generally, the average pore size is preferably several μm to several hundred μm, and the porosity is usually preferably about 30 to 90%. The pore size and porosity are both selected as appropriate according to the number of sweat glands in the applicable skin, the dose of the drug used, and are not particularly limited.

In addition, a material obtained by laser processing a ceramic material, a synthetic resin material, or the like to form a capillary structure can also be suitably used. The thickness of these materials is not particularly limited, but usually 0.1 mm to 10 m
About m is good.

In some cases, a flexible film or sheet material may be used as long as the capillary or the like is non-deformable.

Examples of the carrier liquid described in the present invention include water and an electrolyte solution such as sodium chloride, but are not limited thereto.

Next, the structure and operation of the embodiment of the present invention will be described in detail with reference to the drawings.

In FIG. 1, (1) is a porous ceramic body, and the material is not particularly limited. The porosity is set within the above range. On one surface of the porous body (1), a dried drug is spray-coated to form a drug particle attachment surface (2).

(3) is a conductive member, which is made of a conductive rubber, a conductive polymer, a carbon film, an aluminum foil, a metal foil or the like. The conductive member (3) may be made of a porous member. Although the porosity and the like are appropriately selected, it is sufficient that the carrier liquid is permeated when the carrier liquid is injected.

The laminated structure of the porous body (1), the drug particle-adhering surface (2), and the conductive member (3) is covered and supported and fixed by the flexible support member (6).

An adhesive layer (7) is formed on the support member (6), and the adhesive layer (7) is for fixing the laminated structure to the surface of the living skin.

Before use, it is placed on paper or the like that has been subjected to a silicone coating treatment in the above-described state and stored. In use, the drug particle attachment surface (2) is brought into contact with the living skin.
The reservoir (4), in which the carrier liquid (5) is sealed, is communicated by inserting a hollow needle (8) provided in the reservoir (4) from above the support member (6). Is supplied to the porous body (1) via the hollow needle (8) and the conductive member (3).

Next, electricity is supplied to the conductive member (3). Carrier liquid (5)
Penetrates the conductive member (3) and the porous body (1),
It reaches the drug particle attachment surface (2). The carrier liquid (5) mixes with the drug particle attachment surface (2) and becomes liquid. A liquefied drug layer is formed on the surface of the living skin, and the drug solution penetrates into the living body by electric force.

Since the liquid-particle-adhered surface (2) in the liquid state is allowed to move only in the direction of the living body by the electric force, it is maintained at a high concentration without diffusion.

FIG. 2 is a schematic diagram when actually affixed to the living skin (00).

The support member (22) covers the laminate (21) of the porous body, the conductive member, and the drug layer, and is further adhered to the skin (00) by the adhesive layer provided on the support member (22). I have.

(4) is a reservoir, which shows a piercing connection state with the porous body. (23) is a power supply unit including a battery and a chip-type electronic circuit.

In addition to the adhesive layer, a counter electrode layer (24) made of a conductive member is formed on the outermost periphery of the support member (22).

On the surface of the counter electrode layer (24), the adhesive layer having conductivity is laminated. The counter electrode layer (24) is connected to a counter electrode output terminal of the power supply unit (23).

At the time of energization, a porous body (1), a drug particle-adhered surface (2), a living skin (00), and the like exist between the conductive member (3) shown in FIG. 1 and the counter electrode layer (24) shown in FIG. Electric current flows through the conductive adhesive layer, the drug in the drug layer is liquefied by mixing of the carrier liquid,
Furthermore, it permeates the living skin on the carrier liquid.

The electric output used in the present invention is a depolarized pulse capable of performing stable medication without irritation or pain even if the energized state is slightly deteriorated. Specifically, JP-A-60-15
It is as shown in 6475 publication.

However, not only the above output but also AC or DC can be used depending on the usage mode, and the present invention is not limited to this.

Further, the embodiment shown in FIG. 2 shows a structure in which the power supply unit is integrally mounted. However, the present invention is not limited to this, and the power supply unit may be separated and connected by a lead wire. The shape is appropriately changed depending on the use mode.

Although the drug layer is not limited to its molecular weight or other various amounts, the interface of the present invention maintains the highest possible concentration in terms of the efficiency of iontophoresis, even though the dose is particularly small, and It is mainly useful for peptide drugs such as insulin, which require sufficient water. Examples of drugs are shown below.

Antitussive expectorant sodium cromoglycate, ketotifen fumarate bronchodilator formoterol fumarate analgesic narbuphine hydrochloride, pentazocine lactate, diclofenac sodium cardiotonic agent dopamine hydrochloride psychoneuric stabilizer perphenazine, phenothiazine antibiotic cefotetan disodium sulfate, dibecacin sulfate Netilmycin, sisomicin sulfate Antineoplastic agent Adriamycin, Mitomycin C, Bleomycin hydrochloride, Lentinan, Picibanil, Vincristine sulfate, Cisplatin Circulating function improver Nicametate citrate, Meclofenoxate hydrochloride,
Lisulide maleate, Calcium hopantenate Gout treatment Allopurinol Other peptides LHRH, Enkephalin, Endorphin, Interferon, Insulin, Calcitonin, TRH, Oxytocin, Ripressin, Vasopressin, Glucagon, Pituitary hormone (HGH, HMG, HCG, Desmopressin acetate) There are various methods for forming these dried drug layers, such as spray coating, dipping and drying, and the method is not particularly limited and may be appropriately selected.

As described in detail above, the present invention can supply a suitable amount of water without diluting the drug solution, and since the drug is in a dry state before use, it can be stored for a long time without deterioration, decay, etc., and Since the drug is present only on the surface in contact with the skin and the diffusion of the drug in the direction other than the living body is prevented by the electric force, it has the effect of enabling accurate administration without wasting the drug solution. .

[Brief description of the drawings]

 1 and 2 are views showing an embodiment of the present invention. DESCRIPTION OF SYMBOLS 1 ... Porous body (porous material), 2 ... Drug particle adhesion surface, 3 ... Conductive member, 4 ... Reservoir, 5 ... Carrier liquid, 6 ... Support member, 7 ... Adhesive 00 ... living skin.

──────────────────────────────────────────────────続 き Continuation of the front page (56) References JP-A-2-36885 (JP, A) JP-A-56-75173 (JP, A) JP-A-55-52765 (JP, A) JP-A-1- 263179 (JP, A) JP-A-63-102768 (P, A) JP-A-62-122677 (JP, A) (58) Fields investigated (Int. Cl. ⁶ , DB name) A61N 1/30

Claims (1)

(57) [Claims] 1. An interface for iontophoresis, wherein a drug is arranged on the surface of a porous material.