JP2022104233A - Composition for oral cavity - Google Patents

Abstract

To provide a composition for an oral cavity, such as toothpaste, that makes it possible to obtain a refreshing feeling, is capable of inhibiting an astringent feeling, and is capable of maintaining the inhibitory effect of the astringent feeling.SOLUTION: The present invention provides a composition for an oral cavity containing (A) one or more compounds selected from the group consisting of carbonates, bicarbonates, sulfates and chlorides, and (B) one or more compounds selected from the group consisting of N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide, ethyl-3-(p-menthane-3-carboxamide)acetate, and N-(2-(2-pyridinyl)ethyl)-2-isopropyl-5-methylcyclohexanecarboxamide.SELECTED DRAWING: None

Description

The present invention relates to an oral composition.

Oral compositions such as dentifrices are usually blended with abrasives, surfactants, wetting agents, binders and the like, and nonionic surfactants and the like foam as surfactants to ensure cleanability and the like. Is used for. Further, a method of removing stickiness in the oral cavity and giving a refreshing feeling by adding sodium hydrogen carbonate or other salts has been publicized as well as a physical cleaning feeling with an abrasive or the like. However, sodium hydrogen carbonate and other salts have a refreshing feeling as well as a convergent taste, a peculiar sarcasm, and irritation, which have been problems.

Patent Document 1 states that mucosal irritation could be alleviated while maintaining a refreshing feeling by blending a specific amide betaine-type amphoteric tenside into an oral composition in which sodium hydrogen carbonate and sodium lauryl sulfate were used in combination. Have been described. Patent Document 2 describes that the development of astringency by sodium hydrogen carbonate is suppressed by adding glycine, alanine, leucine, glutamic acid and salts thereof to an oral composition containing a hydrogen carbonate or the like. ing. Patent Document 3 contains one or more waxes selected from lanolin and its derivatives, whale wax, carnauba wax, candelilla wax, and beeswax in an oral composition containing a converging compound such as baking soda. It is described that this can improve the astringency of sodium hydrogen carbonate.

Japanese Unexamined Patent Publication No. 11-49654 Japanese Patent No. 3922329 Japanese Unexamined Patent Publication No. 11-21219

However, the technique of Patent Document 1 is insufficient for improving the convergent taste (convergent feeling). Further, the techniques of Patent Documents 2 and 3 are also insufficient for suppressing the astringent taste, and there is room for improvement in terms of the sustainability of the astringent taste suppressing effect. Convergence (convergence) may lead to discomfort, especially for young people, and the development of means for suppressing it is expected.
An object of the present invention is to provide an oral composition capable of eliminating stickiness in the oral cavity, obtaining a refreshing feeling, suppressing a feeling of convergence, and sustaining the effect of suppressing the feeling of convergence. ..

That is, the present invention provides the following [1] to [8].
[1] One or more selected from the group consisting of (A) carbonate, hydrogen carbonate, sulfate, and chloride, and (B) N- (2-hydroxy-2-phenylethyl) -2-isopropyl-. 5,5-dimethylcyclohexane-1-carboxyamide, ethyl-3- (p-menthan-3-carboxamide) acetate, and N- (2- (2-pyridinyl) ethyl) -2-isopropyl-5-methylcyclohexanecarboxamide An oral composition containing at least one selected from the group consisting of (However, (A) sodium sulfate and (B) ethyl-3- (p-menthan-3-carboxamide) acetate-containing dentin composition. except).
[2] The oral composition according to [1], which satisfies at least one of the following:
The carbonate is at least one selected from the group consisting of sodium carbonate, potassium carbonate, and magnesium carbonate;
Bicarbonate is at least one selected from the group consisting of sodium hydrogen carbonate, potassium hydrogen carbonate, calcium hydrogen carbonate, and magnesium hydrogen carbonate;
The sulfate is at least one selected from the group consisting of sodium sulfate, potassium sulfate, magnesium sulfate, potassium aluminum sulfate, sodium aluminum sulfate, and ammonium aluminum sulfate; and the chloride is sodium chloride, potassium chloride, and At least one selected from the group consisting of magnesium chloride.
[3] The oral composition according to [1] or [2], wherein the content of the component (A) is 0.1 to 10% by mass.
[4] The oral composition according to any one of [1] to [3], wherein the content of the component (B) is 0.00001 to 0.1% by mass.
[5] (C): The oral composition according to any one of [1] to [4], further containing a nonionic surfactant.
[6] The oral composition according to [5], wherein the component (C) contains at least one selected from the group consisting of polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether and polyglycerin fatty acid ester.
[7] The oral composition according to [5] or [6], wherein the content of the component (E) is 0.1 to 1% by mass.
[8] The oral composition according to any one of [1] to [7], which is a dentifrice, a mouthwash, a spray, a coating agent, a patch, or an oral dissolving agent.

According to the present invention, it is possible to provide an oral composition capable of eliminating stickiness in the oral cavity, obtaining a refreshing feeling, suppressing a feeling of convergence, and sustaining the effect of suppressing the feeling of convergence. ..

Hereinafter, the present invention will be described in detail.
The oral composition of the present invention contains the following components (A) and (B), and preferably further contains the component (C).

[(A) component]
The component (A) is at least one selected from the group consisting of carbonates, bicarbonates, sulfates, and chlorides. By containing the component (A), a refreshing feeling can be imparted to the oral composition. When the component (B) is ethyl-3- (p-menthan-3-carboxamide) acetate, the component (A) consists of other than sodium sulfate, that is, carbonate, bicarbonate, aluminum sulfate and chloride. One or more species selected from the group.

Examples of the carbonate include sodium carbonate, potassium carbonate and magnesium carbonate. Examples of the hydrogen carbonate include sodium hydrogen carbonate, potassium hydrogen carbonate, calcium hydrogen carbonate, and magnesium hydrogen carbonate. Examples of the sulfate include sodium sulfate, potassium sulfate, magnesium sulfate, aluminum sulfate and alum, and aluminum sulfate and alum are preferable. Examples of alum include potassium aluminum sulphate, sodium aluminum sulphate, and ammonium chloride aluminum sulphate. Examples thereof include sodium chloride, potassium chloride and magnesium chloride. Examples of alum include potassium aluminum sulfate, sodium aluminum sulfate, and ammonium aluminum sulfate. Of these, sodium hydrogen carbonate, sodium chloride, and potassium aluminum sulfate are preferable. The component (A) may be one kind or a combination of two or more kinds.

The content of the component (A) is usually 0.05% by mass or more, preferably 0.1% by mass or more, more preferably 0.2% by mass or more, based on the entire oral composition (100% by mass). Is. This can give a refreshing feeling. The upper limit is usually 20% by mass or less, preferably 10% by mass or less, and more preferably 5% by mass or less. This makes it possible to suppress the development of a feeling of convergence. Therefore, the content of the component (A) is usually 0.05 to 20% by mass, preferably 0.1 to 10% by mass, more preferably 0.2 to 10% by mass, and further preferably 0.2 to 0.2 to 10% by mass. It is 5% by mass.

[(B) component]
The component (B) is N- (2-hydroxy-2-phenylethyl) -2-isopropyl-5,5-dimethylcyclohexane-1-carboxyamide, ethyl-3- (p-menthane-3-carboxamide) acetate and One or more selected from the group consisting of N- (2- (2-pyridinyl) ethyl) -2-isopropyl-5-methylcyclohexanecarboxamide. By containing the component (B), it is possible to suppress the feeling of convergence and impart its sustainability to the oral composition. As used herein, the term "convergence" means the sensation of tightness in the gums and is distinguished from irritation (simply pain).

The component (B) may be one kind or a combination of two or more kinds, but N- (2-hydroxy-2-phenylethyl) -2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide and N- ( It preferably contains at least 2- (2-pyridinyl) ethyl) -2-isopropyl-5-methylcyclohexanecarboxamide. As a result, it is possible to impart a better effect of suppressing and sustaining the feeling of convergence. Further, it is more preferable to contain at least N- (2-hydroxy-2-phenylethyl) -2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide. As a result, the effect of suppressing the feeling of convergence can be further sustained, and a better feeling of refreshment can be imparted.

The content of the component (B) is usually 0.000001% by mass or more, preferably 0.00001% by mass or more, and more preferably 0.00005% by mass or more with respect to the entire oral composition (100% by mass). Is. As a result, the effect of suppressing the feeling of convergence and the effect of sustaining the feeling of convergence can be exerted. The upper limit is usually 0.5% by mass or less, more preferably 0.1% by mass or less, still more preferably 0.01% by mass or less, still more preferably 0.005% by mass or less. As a result, it is possible to suppress the expression of irritation in the oral cavity and the decrease in flavor expression. Therefore, the content of the component (B) is usually 0.000001 to 0.5% by mass, preferably 0.00001 to 0.1% by mass, and more preferably 0.00001 to 0.01% by mass. More preferably, it is 0.00005 to 0.005% by mass.

[(C) component]
The component (C) is a nonionic surfactant. By containing the component (C), it is possible to impart an effect of suppressing a feeling of convergence to the oral composition.

Examples of the nonionic surfactant include polyoxyethylene alkyl ether, polyoxyethylene hydrogenated castor oil, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester (eg, polyoxyethylene sorbitan monostearate), alkyrrole amide, and polyoxy. Ethylene fatty acid esters, polyoxyethylene alkenyl ethers, glycerin fatty acid esters, sucrose fatty acid esters (eg, Martose fatty acid esters), sugar alcohol fatty acid esters (eg, multitoll fatty acid esters, lactitol fatty acid esters), fatty acid diethanolamides (eg, lauryl). Acid mono or diethanolamide), polyoxyethylene polyoxypropylene copolymer, polyoxyethylene polyoxypropylene fatty acid ester, and the like. The number of carbon atoms in the alkyl chain of the polyoxyethylene alkyl ether is usually 14 to 18, and the average number of moles of ethylene oxide added is usually 15 to 30 mol. The average number of moles of ethylene oxide added to the polyoxyethylene hydrogenated castor oil is usually 20 to 100 mol, preferably 20 to 60 mol. The number of carbon atoms of the fatty acid of the sorbitan fatty acid ester is usually 12 to 18. The number of carbon atoms of the fatty acid of the polyoxyethylene sorbitan fatty acid ester is usually 16 to 18, and the average number of moles of ethylene oxide added is usually 10 to 40 mol. The number of carbon atoms in the alkyl chain of the alkylolamide is usually 12 to 14. As the nonionic surfactant, polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, and polyoxyethylene alkyl ether are preferable.

The content of the component (C) is usually 0.01% by mass or more, preferably 0.1% by mass or more, more preferably 0.3% by mass, based on the entire oral composition (100% by mass). That is all. This makes it possible to impart a good effect of suppressing a feeling of convergence. The upper limit is usually 5% by mass or less, preferably 1% by mass or less, and more preferably 0.8% by mass or less. This makes it possible to suppress a decrease in refreshing feeling and a decrease in flavor expression. Therefore, the content of the component (C) is usually 0.01 to 5% by mass, preferably 0.1 to 1% by mass, more preferably 0.3 to 1% by mass, and further preferably 0.3. It is about 0.8% by mass.

[Arbitrary ingredient]
The oral composition of the present embodiment may contain arbitrary components other than the components (A) to (C) already described, as long as the effects of the present invention are not impaired.

Examples of the optional component include a surfactant, a sweetener, a fragrance, a medicinal component, an oily component, an abrasive, a preservative, a wetting agent, a binder, a pH adjuster, a colorant (dye), and a solvent. Hereinafter, a specific description will be given.

-Abrasive-
The abrasive may be either an inorganic abrasive or an organic abrasive. Examples of the inorganic abrasive include abrasive silica such as precipitate silica, aluminosilicate, zirconosilicate, crystalline zirconium silicate, and titanium-binding silica; calcium dibasic phosphate / dihydrate or anhydrous, calcium primary phosphate. , Calcium phosphate-based compounds such as tertiary calcium phosphate, calcium pyrophosphate; calcium carbonate-based abrasives such as calcium carbonate; calcium hydroxide-based abrasives other than carbonic acid / phosphoric acid such as calcium hydroxide and calcium sulfate; aluminum oxide, aluminum hydroxide, Aluminum-based materials such as alumina; Silica-based materials such as silicic acid anhydride, zeolite, and zirconium silicate; Magnesium-based materials such as magnesium carbonate and tertiary magnesium phosphate; Apatite-based materials such as hydroxyapatite, fluoroapatite, and calcium-deficient apatite. Materials: Titanium-based materials such as titanium dioxide, mica titanium, and titanium oxide; minerals such as bentonite can be mentioned. Examples of the organic abrasive include polymethylmethacrylate and synthetic resin-based abrasives. Of these, a silica-based abrasive is preferable.

The content of the abrasive is usually 70% by mass or less, preferably 50% by mass or less, and more preferably 8 to 50% by mass with respect to the entire oral composition (100% by mass).

-Surfactant-
Examples of the surfactant other than the component (C) include an anionic surfactant, an amphoteric surfactant, and a cationic surfactant.

Examples of the anionic surfactant include alkyl sulfates, acyl amino acid salts, acyl taurine salts, α-olefin sulfonates, hydrogenated coconut fatty acid monoglyceride monosulfates, and lauryl sulfoacetates. The alkyl group and the acyl group may be either a straight chain or a branched chain, and may be saturated or unsaturated, and the number of carbon atoms thereof is usually 10 to 20, preferably 12 to 18, and more preferably 12 to 18. It is 14. The salt can be selected from pharmacologically acceptable salts. Pharmacologically acceptable salts include, for example, base addition salts and amino acid salts. Specific examples thereof include inorganic base salts such as sodium salt, potassium salt, calcium salt, magnesium salt and ammonium salt; organic base salts such as triethylammonium salt, triethanolammonium salt, pyridinium salt and diisopropylammonium salt; arginine salt and the like. Basic amino acid salts of. Of these, inorganic base salts are preferred, alkali metal salts (eg, sodium salts, potassium salts) or ammonium salts are more preferred, and sodium salts are even more preferred.

Examples of the alkyl sulfate include lauryl sulfate (sodium lauryl sulfate) and myristoyl sulfate. Examples of the acyl amino acid salt include acyl sarcosine salts such as lauroyl sarcosin salt and myristoyl sarcosin salt; acyl glutamates such as lauroyl glutamate, myristoyl glutamate and palmitoyl glutamate; N-lauroyl-N-methylglycine salt and cocoyl glycine. Acylglycine salts such as salts; N-lauroyl-β-alanine salt, N-myristyl-β-alanine salt, N-cocoyl-β-alanine salt, N-lauroyl-N-methyl-β-alanine salt, N-myristoyl Acylalanine salts such as -N-methyl-β-alanine salt, N-methyl-N-acylalanine salt; acylasparaginate such as lauroyl asparagate can be mentioned. Examples of the acyl taurine salt include lauroylmethyl taurine salt, N-methyl-N-acyl taurine salt, and N-cocoyl methyl taurine salt. Examples of the α-olefin sulfonate include α-olefin sulfonates having 12 to 18 carbon atoms such as tetradecene sulfonate. Other examples of anionic surfactants include hydrogenated coconut fatty acid monoglyceride sodium monosulfate, sodium lauryl sulfoacetate.

The anionic surfactant preferably contains a sulfonic acid group in terms of foaming and good foam quality, and an alkyl sulfate and an α-olefin sulfonate are more preferable.

Examples of the amphoteric surfactant include betaine-type amphoteric surfactants such as alkyldimethylaminoacetic acid betaine (eg, lauryldimethylaminoacetic acid betaine) and fatty acid amide propyldimethylaminoacetic acid betaine (eg, cocamidopropyl betaine); N-. Fatty acid acyl-N-carboxymethyl-N-hydroxyethylethylenediamine salt (eg, N-palm oil fatty acid acyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine), coconut oil fatty acid imidazolinium betaine, 2-alkyl Examples include imidazoline-type amphoteric surfactants such as -N-carboxymethyl-N-hydroxyethyl imidazolinium betaine; alkyl betaines such as lauryldimethylaminoacetic acid betaine. Examples of the cationic surfactant include an alkylammonium salt and an alkylbenzylammonium salt.

Examples of the cationic surfactant include an alkylammonium salt and an alkylbenzylammonium salt.

The content of the surfactant (other than the component (C)) is preferably 0.1 to 3% by mass, more preferably 0.6 to 2.5% by mass, based on the entire oral composition (100% by mass). , More preferably 1 to 2.5% by mass.

-Wetting agent-
When the composition contains a wetting agent, the feeling of use can be further improved.

As the wetting agent, sugar alcohols and polyhydric alcohols other than sugar alcohols are preferable. Examples of the sugar alcohol include sugar alcohols such as sorbitol, erythritol, maltitol, lactitol, xylitol, and reduced starch saccharified; glycerin; polyhydric alcohols such as ethylene glycol, propylene glycol, dipropylene glycol, butylene glycol, and polyethylene glycol. Can be mentioned. Examples of the polyethylene glycol include polyethylene glycol having an average molecular weight of 150 to 6000, and polyethylene glycol having an average molecular weight of 190 to 630 is preferable. Specific examples thereof include PEG200, PEG300, PEG400 and PEG600. The content of the wetting agent is usually 40% by mass or less, preferably 1 to 30% by mass, based on the entire oral composition (100% by mass). The average molecular weight is the average molecular weight described in the Quasi-drug Raw Material Standard 2006.

-Medicated ingredients-
Examples of medicinal ingredients include bactericidal or antibacterial agents such as cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, isopropylmethylphenol, zinc gluconate, zinc citrate, triclosan, timol, hinokithiol, and lysoteam chloride; Enzymes such as mutanase, amylase, protease, lytecenzyme; fluorides such as sodium fluoride, sodium monofluorophosphate, tin fluoride; ε-aminocaproic acid, allantin, tranexamic acid, glycyrrhizinate (eg, glycyrrhetin dipotassium salt) ), Anti-inflammatory agents such as glycyrrhetinic acid, glycyrrhetinate (eg, stearyl glycyrrhetinate), allantinchlorhydroxyaluminum, azulene, dihydrocholesterol; metal salts such as zinc, copper salt, tin salt; condensed phosphate, ethanehydroxy Toothstone preventive agent such as diphosphonate; Blood flow promoter such as vitamin E (for example, tocopherol acetate); Sensitivity inhibitor such as potassium nitrate, aluminum lactate, strontium chloride; Coating agent such as hydroxyethyl cellulose dimethyldiallyl ammonium chloride; Astringents other than component (A) such as vitamin C (eg, ascorbic acid or a salt thereof), lysoteam chloride; water-soluble copper compounds such as copper chlorophyll and copper gluconate; amino acids such as tooth stone preventives, alanine, glycine and proline. Kinds, thyme, ginger, chowji, hamamelis and other plant extracts; caropeptides, polyvinylpyrrolidone and the like. The medicinal ingredient may be used alone or in combination of two or more. The content of the above medicinal component can be appropriately set as an effective amount according to a conventional method.

-Fragrance-
When the composition contains a fragrance, the feeling of use can be further improved. Examples of fragrances include peppermint oil, sparemint oil, Japanese peppermint oil, anis oil, cassia oil, eucalyptus oil, winter green oil, mastic oil, neroli oil (orange flower oil), lemongrass oil, jasmine oil, and rose oil. , Iris oil, clove oil, thyme oil, sage oil, cardamon oil, rosemary oil, laurel oil, chamomil oil, caraway oil, basil oil, majorum oil, lemon oil, orange oil, lime oil, yuzu oil, nutmeg oil , Lavender oil, Paracres oil, Vanilla oil, Katsura skin oil, Pimento oil, Katsura leaf oil, Perilla oil, Winter green oil and other natural essential oils; , Timor, linalol, limonen, menton, mentylacetate, citral, decanal, camphor, borneol, pinen, spirantol, n-decyl alcohol, citronellol, α-terpineol, citronellyl acetate, cineole, ethyllinalol, varnish and other natural essential oils. Fragrance components contained in; fragrance components such as ethyl acetate, ethyl butyrate, isoamyl acetate, hexanal, hexenal, methyl anthranilate, ethyl methyl phenylglycidate, benzaldehyde, vanillin, ethyl vaniline, flaneol; and some fragrances. Examples include various blended flavors such as mint-based, fruit-based, and herbal-based, which are a combination of ingredients and natural essential oils. As the fragrance, the above-exemplified fragrance may be used alone or in combination of two or more.

-Sweetener-
When the composition contains a sweetener, the feeling of use can be further improved. Examples of the sweetener include saccharin, saccharin sodium, aspartame, stebioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidin dihydrochalcone, perillartine, glycyrrhizin, thaumatin, aspartylphenylalanine methyl ester and the like. As the sweetener, the above-exemplified sweetener may be used alone or in combination of two or more.

-Oil component-
Examples of the oily component include hydrocarbons such as squalane, liquid paraffin, vaseline, and microcrystalin wax; and having 8 carbon atoms such as higher alcohols (eg, lauryl alcohol, cetyl alcohol, cetostearyl alcohol, oleyl alcohol, and isostearyl alcohol). ~ 22 alcohols); higher fatty acids (eg, fatty acids with 8 to 22 carbon atoms such as lauric acid, myristic acid, oleic acid, isostearic acid), vegetable oils such as olive oil, castor oil, coconut oil; Examples include fatty acid esters.

-Preservative-
When the composition contains a preservative, the antiseptic power of the pharmaceutical product can be ensured. Examples of the preservative include paraoxybenzoic acid esters (for example, methyl paraoxybenzoate, ethyl paraoxybenzoate, butyl paraoxybenzoate), sodium benzoate and the like. The preservative may be used alone or in combination of two or more.

-Blotting agent-
When the composition contains an arbitrary binder, the viscosity can be optimized, and the shape retention and usability can be further improved. As the binder, any suitable organic binder conventionally known, for example, a polysaccharide, a cellulosic binder (for example, carboxymethyl cellulose (CMC), hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose, methyl cellulose, cation) Celluloseized cellulose, etc.), other polysaccharide thickeners (eg, xanthan gum, gua gum, gellan gum, tragant gum, karaya gum, arabiya gum, locust bean gum, carrageenan, sodium alginate), synthetic water-soluble polymers (eg, sodium polyacrylate, etc.) Cardovinyl polymer, polyvinylpyrrolidone, polyvinyl alcohol, propylene glycol alginate) can be mentioned. Further, an inorganic binder such as thickening silica and aluminum silicate can be blended. The content of any organic binder is preferably 0 to 3% by mass, more preferably 0.1 to 2% by mass, based on the entire oral composition (100% by mass). The content of the inorganic binder is preferably 0 to 10% by mass, more preferably 1 to 8% by mass.

-PH regulator-
When the composition contains a pH adjuster, the pH stability of the pharmaceutical product can be ensured. Examples of the pH adjuster include organic acids such as phthalic acid, citric acid, succinic acid, acetic acid, fumaric acid, malic acid and lactic acid, or salts thereof (sodium citrate) and inorganic acids such as phosphoric acid (orthoric acid). Acids or hydroxides thereof such as salts thereof (eg, potassium salt, sodium salt and ammonium salt), sodium hydroxide, potassium hydroxide and the like can be mentioned. Examples of the inorganic acid salt include disodium hydrogen phosphate and sodium dihydrogen phosphate.

The content of the pH adjuster can usually be such that the pH of the oral composition after addition is 5 to 9, preferably 6 to 8.5.

In the present specification, the pH value usually refers to a value at 25 ° C. and 3 minutes after the start of measurement. The pH value can be measured using, for example, a pH meter (model number Hm-30S) manufactured by Toa Denpa Kogyo Co., Ltd.

-Colorant-
Examples of the colorant include natural pigments such as Benibana red pigment, Kuchinashi yellow element, Kuchinashi blue pigment, perilla pigment, red koji pigment, red cabbage pigment, carrot pigment, hibiscus pigment, cacao pigment, spirulina blue pigment, and tamarind pigment. Legal dyes such as Red No. 2, Red No. 3, Red No. 104, Red No. 105, Red No. 106, Red No. 227, Yellow No. 4, Yellow No. 5, Green No. 3, Blue No. 1, Riboflavin, Copper Chlorophine Sodium , Titanium dioxide and the like. When the oral composition contains a colorant, the content thereof is preferably 0.00001 to 3% by mass with respect to the entire oral composition.

-solvent-
Examples of the solvent include water (purified water), ethanol and the like, and water is preferable. As the solvent, one type may be used alone or two or more types may be used in combination.

-Other optional ingredients-
Examples of optional components other than the above include polyisobutylene, polybutadiene, urethane, silicon, and natural rubber. The content of these other optional components can be appropriately set as long as the effect of the present invention is not impaired.

[Dosage form and use of oral composition]
The oral composition of the present invention can be an oral preparation such as a dentifrice, a mouthwash, a spray, a coating agent, a patch, or an oral lysing agent. It can be appropriately selected depending on the form, and is not particularly limited. The dosage form is, for example, in the form of a paste or liquid, and if it is a dentifrice, it can be prepared as a dentifrice, a liquid dentifrice, a liquid dentifrice, or a dentifrice.

[Method for producing composition]
The method for producing the oral composition is not particularly limited, and can be prepared by each usual method depending on the dosage form. For example, when it is used as a dentifrice, a method of preparing a component that dissolves in a solvent, mixing other insoluble components, and defoaming (for example, reducing the pressure) as necessary can be mentioned. The obtained toothpaste can be contained in a container and made into a product. The shape and material of the container are not particularly limited, and a container used for a normal dentifrice composition can be used. For example, a container such as a plastic laminated tube such as polyethylene, polypropylene, polyethylene terephthalate, or nylon can be used. Be done.

Hereinafter, the present invention will be specifically described with reference to Examples and Comparative Examples. The present invention is not limited to the following examples. The numerical values in the table below represent mass% unless otherwise specified.

[Ingredients used in Examples and Comparative Examples]
-(A) component-
Sodium hydrogen carbonate: Sodium bicarbonate (manufactured by Asahi Glass Co., Ltd.)
Sodium sulfate: Anhydrous sodium sulfate (manufactured by Tomita Pharmaceutical Co., Ltd.)
Sodium chloride: (Selected special grade salt, Nihonkaisui Co., Ltd.)
Potassium aluminum sulfate: (manufactured by Taimei Chemicals Co., Ltd.)

-(B) component-
N- (2-Hydroxy-2-phenylethyl) -2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide: (Coolact® 370, manufactured by Takasago International Corporation)
Ethyl-3- (p-menthane-3-carboxamide) acetate: (WS-5, manufactured by Toyoda Fragrance Co., Ltd.)
N- (2- (2-pyridinyl) ethyl) -2-isopropyl-5-methylcyclohexanecarboxamide: (Evercool® 190, manufactured by Givaudan)
N-Ethyl-p-Menthane-3-carboxamide: (WS-3, manufactured by Simrise Japan)

-(C) component-
Polyoxyethylene (20) Hardened castor oil: (manufactured by Nippon Emulsion Co., Ltd.)

Ingredients other than the components (A) to (C) Abrasive silica: Tixosil (registered trademark) 73 (manufactured by Solvay)
Sodium fluoride: (manufactured by Stella Chemipha Co., Ltd.)
Sodium lauryl sulfate: (manufactured by BASF)
Sorbitol liquid (70%): (manufactured by Mitsubishi Corporation Life Science Co., Ltd.)
Propylene glycol: (manufactured by ADEKA)
Viscous silica: Carplex (registered trademark) # 67 (manufactured by DSL Japan Co., Ltd.)
Saccharin sodium: (manufactured by Aisan Chemical Industry Co., Ltd.)
For ingredients other than the above, raw materials conforming to the quasi-drug raw material standard 2006 were used.

Examples 1-28 and Comparative Examples 1-8
Using the above components as raw materials, dentifrices having the composition shown in Tables 1 to 5 below were prepared according to the preparation method described later.

[Preparation method of dentifrice]
The raw materials shown in Tables 1 to 5 were blended by a conventional method to obtain a dentifrice, which was housed in a laminated tube.

[Evaluation method]
The feeling of use of the dentifrice was evaluated by four subject panelists. Place 1g of sample dentifrice on a toothbrush (Clinica Advantage Toothbrush, 4-row compact normal type, manufactured by Lion Corporation), brush the teeth for 3 minutes, and maintain the refreshing feeling, the effect of suppressing the feeling of convergence, and the effect of suppressing the feeling of convergence. The sex was judged according to the score criteria shown below. The average of the scores of the four people was calculated and evaluated according to the following evaluation criteria.

<Refreshing feeling>
Regarding the refreshing feeling, the refreshing feeling was evaluated depending on the presence or absence of stickiness in the oral cavity after rinsing the oral cavity with water after brushing the teeth.
Rating criteria 4 points: Very refreshing feeling 3 points: Feeling refreshing feeling 2 points: Not feeling refreshing feeling 1 point: Feeling refreshing feeling Evaluation criteria ◎: Average score 3.5 points or more 4.0 points or less ○: Average score 3.0 points or more and less than 3.5 points Δ: Average score 2.0 points or more and less than 3.0 points ×: Average score less than 2.0 points

<Suppressing effect of convergence>
Regarding the effect of suppressing the feeling of convergence, the strength of the feeling of convergence immediately after rinsing the oral cavity with water after brushing the teeth was evaluated.
Evaluation criteria 4 points: No sense of convergence 3 points: Almost no sense of convergence 2 points: Feeling of convergence 1 point: Feeling of convergence very strongly Judgment criteria ☆: Average score 3.8 points 4.0 points or less ◎: Average score 3.5 points or more and less than 3.8 points ○: Average score 3.0 points or more and less than 3.5 points △: Average score 2.0 points or more and less than 3.0 points ×: Average score less than 2.0 points

<Durability of the effect of suppressing the feeling of convergence>
Regarding the sustainability of the effect of suppressing the feeling of convergence, the time when the feeling of convergence was not felt after rinsing the oral cavity with water after brushing the teeth was evaluated.
Evaluation criteria 4 points: 25 minutes or more (no irritation was felt)
3 points: 15 minutes or more and less than 25 minutes 2 points: 5 minutes or more and less than 15 minutes 1 point: less than 5 minutes Judgment criteria ◎: Average score 3.5 points or more and 4.0 points or less ○: Average score 3.0 points or more 3 . Less than 5 points Δ: Average score of 2.0 points or more and less than 3.0 points ×: Average score of less than 2.0 points

In Comparative Example 1 containing only the component (B), the evaluation of the refreshing feeling was low, and in Comparative Examples 2 to 6 containing only the component (A), the effect of suppressing the feeling of convergence on the oral mucosa was low (Table 5). On the other hand, in Examples 1 to 28, which are combinations of the components (A) and (B), the evaluation of the effect of suppressing the feeling of refreshment and the feeling of convergence was good, and the effect of suppressing the feeling of convergence was also sustained (Table). 1-4). Above all, in Examples 24 to 28 in which the component (C) was further used, the effect of suppressing the feeling of convergence was better (Table 4).
In Comparative Example 8 having only the control component of (B), the evaluation of the refreshing feeling was low as in Comparative Example 1 having only the component (B), but in Comparative Example 7 in which the component (A) was combined, (A). ) And (B), as in Comparative Examples 2 to 6, the effect of suppressing the astringency on the oral mucosa was low, and the effect of adding the control component of (B) could not be found (Table 5).
These results indicate that the oral composition of the present invention can exhibit a refreshing feeling by eliminating stickiness in the oral cavity, can suppress the feeling of convergence, and can maintain the effect of suppressing the feeling of convergence.

Claims (8)

(A) One or more selected from the group consisting of carbonate, hydrogen carbonate, sulfate, and chloride, and (B) N- (2-hydroxy-2-phenylethyl) -2-isopropyl-5,5. -Dimethylcyclohexane-1-carboxyamide, ethyl-3- (p-menthan-3-carboxamide) acetate, and N- (2- (2-pyridinyl) ethyl) -2-isopropyl-5-methylcyclohexanecarboxamide. Oral compositions containing at least one selected from (excluding (A) sodium sulfate and (B) dentin composition containing ethyl-3- (p-menthan-3-carboxamide) acetate). The oral composition according to claim 1, which satisfies at least one of the following:
The carbonate is at least one selected from the group consisting of sodium carbonate, potassium carbonate, and magnesium carbonate;
Bicarbonate is at least one selected from the group consisting of sodium hydrogen carbonate, potassium hydrogen carbonate, calcium hydrogen carbonate, and magnesium hydrogen carbonate;
The sulfate is at least one selected from the group consisting of sodium sulfate, potassium sulfate, magnesium sulfate, potassium aluminum sulfate, sodium aluminum sulfate, and ammonium aluminum sulfate; and the chloride is sodium chloride, potassium chloride, and At least one selected from the group consisting of magnesium chloride. The oral composition according to claim 1 or 2, wherein the content of the component (A) is 0.1 to 10% by mass. (B) The oral composition according to any one of claims 1 to 3, wherein the content of the component (B) is 0.00001 to 0.1% by mass. (C): The oral composition according to any one of claims 1 to 4, further containing a nonionic surfactant. The oral composition according to claim 5, wherein the component (C) contains at least one selected from the group consisting of polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether and polyglycerin fatty acid ester. The oral composition according to claim 5 or 6, wherein the content of the component (E) is 0.1 to 1% by mass. The oral composition according to any one of claims 1 to 7, which is a dentifrice, a mouthwash, a spray, a coating agent, a patch, or an oral dissolving agent.