JP2021155051A - package - Google Patents

Abstract

To provide a package of a test strip for immunochromatography, which allows immunochromatography to be performed with higher safety and the test result to be appropriately confirmed.SOLUTION: A package according to one embodiment is used for an immunochromatography method, and contains a test strip comprising a sample supply part and a result display part. The package comprises: a first member having a reception part for receiving the test strip; and a second member containing the test strip together with the first member. A region, facing the result display part, of the second member is a transparent region. A seal part is formed in an outer side of the reception part of an overlapping region of the first member and the second member. The seal part has a first seal part, and a second seal part having stronger peeling strength than the first seal part. The second seal part is formed on the result display part side of the sample supply part of the test strip. The first seal part is formed on the sample supply part side of the second seal part of the seal part.SELECTED DRAWING: Figure 3

Description

The present invention relates to a package containing a test strip for an immunochromatographic method.

As one of the rapid test methods using the antigen-antibody reaction, a chromatographic detection device (hereinafter referred to as "test strip") as described in Patent Document 1 is known. Such test strips have traditionally been encapsulated in a package formed by stacking two opaque films and further sealing the edges of the two films. At the time of inspection, the two films in the above package are completely peeled off. The test strip thus taken out of the package was used for inspection.

International Publication No. 2005/121794

The test using the test strip is performed by supplying a sample (for example, blood) to the test strip. Therefore, the sample remains on the test strip after the test. Therefore, there is a risk of secondary infection due to the test strip after the test. In order to prevent such secondary infection, the two films are not completely peeled off, but the two films are partially peeled off so as to expose the part of the test strip that supplies the sample. Can be considered. In this case, after supplying the sample to the test strip, the peeled portion can be restored and the test strip can be covered with the above two films.

However, when the two films are partially peeled off, a sufficient gap is not secured between the two films in the unpeeled portion. Since the sample is a liquid, it is conceivable that the sample moves between the two films due to a capillary phenomenon when the sample is supplied to the test strip. In this case, the sample moves to a part other than the test strip, causing bleeding due to the sample, and it is difficult to confirm the test result.

Therefore, an object of the present invention is to provide a package of a test strip for immunochromatography, which can perform immunochromatography with higher safety and can appropriately confirm the test result.

The package according to one aspect of the present invention includes a test strip including a sample supply section on which a sample to be tested by an immunochromatography method is dropped and a result display section showing the test results of the sample dropped on the sample supply section. A package to be included, the first member having an accommodating portion including a bottom wall on which the test strip is arranged and a side peripheral wall surrounding the test strip, and the first member provided on the first member. A second member including the test strip is provided, and a region of the second member facing the result display portion of the test strip is a transparent region, and the first member and the second member A seal portion in which the first member and the second member are sealed is formed in the outer portion of the overlapping region so as to surround the accommodating portion, and the seal portion is the first. It has one seal portion and a second seal portion having a stronger peeling strength than the first seal portion, and the second seal portion is formed on the result display portion side of the sample supply portion of the test strip. The first seal portion is a portion of the seal portion on the sample supply portion side of the second seal portion.

In the above configuration, the test strip is housed in the housing of the first member and is covered by the second member. The test strip is sealed in the package because the perimeter of the containment is sealed with a seal. The first seal portion is a portion of the seal portion on the sample supply portion side with respect to the second seal portion. When using the test strip, the sample is supplied to the sample supply unit. Therefore, the package is opened with the end on the first seal portion side as the opening end. Since the peel strength of the second seal portion is stronger than that of the first seal portion, the peeling stops at the second seal portion. That is, the package is partially opened. The second seal unit is located closer to the result display unit than the sample supply unit. Therefore, the sample supply unit can be exposed and the sample can be supplied to the sample supply unit by partially opening the package as described above. Since the package is partially opened, the accommodating portion can be closed again with the second member after the sample is supplied to the sample supply unit. Therefore, even if the test result is positive (pathogen, virus, etc. are present in the sample), secondary infection can be prevented. Further, since the region of the second member facing the result display is a transparent region, the inspection result can be visually observed even if the accommodating portion is closed again with the second member. That is, by using the package, the inspection result can be confirmed safely. Since the test strip is housed in the housing part of the first member, the sample does not move due to the capillary phenomenon between the surface of the first member on the second member side and the second member. This prevents the sample from bleeding on and around the test strip. As a result, the inspection result can be confirmed appropriately.

The seal width of the second seal portion may be longer than the seal width of the first seal portion. As a result, the peel strength of the second seal portion can be made stronger than that of the first seal portion.

A package according to another aspect of the present invention is a test strip including a sample supply unit into which a sample to be tested by an immunochromatography method is dropped and a result display unit showing the test results of the sample dropped into the sample supply unit. A first member having an accommodating portion including a bottom wall on which the test strip is arranged and a side peripheral wall surrounding the test strip, and a first member arranged to face the first member. A second member having a through hole for supplying the sample formed at a position facing the sample supply unit, and a cover that closes the through hole and is removable to the second member. In the second member, the region facing the result display portion is a transparent region, and the outer portion of the overlapping region between the first member and the second member is the accommodating portion. A sealing portion is formed in which the first member and the second member are sealed so as to surround the first member.

In the above configuration, the test strip is housed in the housing of the first member and is covered by the second member and the cover. The test strip is sealed in the package because the perimeter of the containment is sealed with a seal. By peeling the cover from the second member, the through hole formed in the second member is exposed, so that the sample can be supplied to the sample supply portion of the test strip through the through hole. Further, after the sample is supplied to the sample supply unit, the test strip can be included in the package by reclosing the through hole of the second member with the cover. Therefore, even if the test result is positive (pathogen, virus, etc. are present in the sample), secondary infection can be prevented. Further, since the region of the second member facing the result display is a transparent region, the inspection result can be visually observed even if the accommodating portion is closed again with the second member. That is, by using the package, the inspection result can be confirmed safely. Since the test strip is housed in the housing part of the first member, the sample does not move due to the capillary phenomenon between the surface of the first member on the second member side and the second member. Therefore, the sample does not bleed on and around the test strip. As a result, the inspection result can be confirmed appropriately.

The color of the bottom wall of the accommodating portion in the region corresponding to the result display portion when viewed from the test strip side may be white. This makes it easy to visually confirm the inspection result.

The bottom wall of the housing may include a white paper sheet. As a result, the color of the bottom wall can be white.

The first member may have the accommodating portion and the flange portion provided at the end portion of the accommodating portion on the second member side. In this case, the first member is, for example, a tray-shaped member.

The first member is an integrally molded product of the accommodating portion and the flange portion, and the first member may include a white paper sheet. In this case, it is easy to manufacture the first member. Further, the color of the region of the bottom wall of the accommodating portion corresponding to the result display portion (color when viewed from the test strip side) may be white.

The first member includes a plate and a back sheet joined to the back surface of the plate, and the plate is formed with a through hole having an inner wall surface forming a side peripheral wall of the accommodating portion. The accommodating portion may be formed by the inner wall surface of the through hole and the back sheet.
In this case, since it is easy to secure the thickness of the entire package, the package is easy to handle.

The back sheet may include a white paper sheet. In this case, for example, the amount of resin used can be reduced as compared with the case where the back sheet is formed only of the resin film. Further, the color of the region of the bottom wall of the accommodating portion corresponding to the result display portion (color when viewed from the test strip side) may be white.

According to the present invention, it is possible to provide a package of a test strip for immunochromatography, which can perform immunochromatography with higher safety and can appropriately confirm the test result.

FIG. 1 is a plan view of an example of a test strip included in a package. FIG. 2 is an exploded perspective view of the package according to the first embodiment. FIG. 3 is a plan view of the package shown in FIG. FIG. 4 is a cross-sectional view taken along the line IV-IV of FIG. FIG. 5 is a drawing for explaining a modified example of the seal portion. FIG. 6 is a drawing for explaining how to use the package. FIG. 7 is an exploded perspective view of the package according to the second embodiment. FIG. 8 is a cross-sectional view of the package according to the second embodiment. FIG. 9 is an exploded perspective view of the package according to the third embodiment. FIG. 10 is a plan view of the package shown in FIG.

Hereinafter, embodiments of the present invention will be described with reference to the drawings. The same elements are designated by the same reference numerals. Duplicate description will be omitted. The dimensional ratios in the drawings do not always match those described.

FIG. 1 is a plan view of an example of the test strip TS included in the package disclosed herein. The test strip TS is a test piece for performing an immunochromatography method and extends in one direction. The test strip TS is used for HIV antibody test, pregnancy judgment, influenza test and the like.

In the test strip TS, a sample pad 1 (sample supply unit), a conjugate pad 2, a membrane 3 and an absorption pad 4 are arranged from one end to the other end. The sample pad 1, the conjugate pad 2, the membrane 3, and the absorption pad 4 are arranged on a support (not shown).

The sample pad 1 is a sample supply unit into which a sample is dropped. The conjugate pad 2 is a pad that is arranged so as to be in contact with the sample pad 1, is capable of deploying a sample, and contains a labeled substance (for example, an antibody or antigen labeled with gold colloid). The membrane 3 is arranged so as to be in contact with the conjugate pad 2, and is a porous body in which the sample can move by capillarity. A test line L1 for detecting the presence or absence of a substance to be detected (substance to be detected) is formed on the membrane 3. The test line L1 is formed by fixing a trap (antigen or antibody against the detection target substance) that captures the detection target substance in a line shape. The membrane 3 may be provided with a control line L2. The control line L2 is a line for confirming that the labeled substance reacts normally with the substance to be detected. Usually, a capture antibody that captures the label is immobilized. In the test strip TS, the portion of the membrane 3 is the result display part where the result of the immunochromatography is shown. The absorption pad 4 is a pad for absorbing a sample.

The length of the test strip TS in the extending direction is, for example, 30 mm to 150 mm, and an example of the length in the width direction (direction orthogonal to the extending direction) is 2 mm to 15 mm. An example of the thickness of the test strip TS is 12 μm to 3000 μm.

Examples of the sample for the test of the test strip TS include blood (whole blood, serum, plasma), nasal swab, nasal aspirate, nasal discharge, pharyngeal swab, saliva, sputum, stool, urine and the like. In the following, unless otherwise noted, the sample is blood.

Hereinafter, various forms of the package containing the test strip TS will be described.

(First Embodiment)
FIG. 2 is an exploded perspective view of the package 10 according to the first embodiment. FIG. 3 is a plan view of the package 10 shown in FIG. 2 and 3 show a state in which the package 10 includes the test strip TS. FIG. 4 is a cross-sectional view taken along the line VI-VI of FIG. For convenience of explanation, as shown in FIGS. 2 to 4, the extending direction of the test strip TS is the X direction, the direction orthogonal to the extending direction is the Y direction, and the test strip TS is orthogonal to the X direction and the Y direction. The direction is called the Z direction.

The package 10 has a first member 11 and a second member 12.

The first member 11 is a tray-shaped member having an accommodating portion 13 and a flange portion 14 (or an overhanging portion).

The accommodating portion 13 is a box-shaped portion having an opening on one side, and accommodates the test strip TS. The accommodating portion 13 has a bottom wall 131 on which the test strip TS is arranged and a side peripheral wall 132 surrounding the test strip TS arranged on the bottom wall 131. The test strip TS is fixed to the bottom wall 131 with glue or the like, for example.

In the first embodiment, the color of the bottom wall 131 is white when viewed from the test strip TS side. The side peripheral wall 132 may extend toward the opening side of the accommodating portion 13. Alternatively, the four walls forming the side peripheral wall 132 may be substantially orthogonal to the bottom wall 131.

The size of the accommodating portion 13 is a size that can accommodate the test strip TS, and may be a size that creates a gap (space) around the test strip TS (side and above) (see FIG. 4).

Specifically, the accommodating portion 13 extends in the X direction. An example of the length of the accommodating portion 13 in the X direction is 40 mm to 160 mm. An example of the length of the accommodating portion 13 in the Y direction is 3 mm to 20 mm. When the accommodating portion 13 extends toward the opening side, the length of the accommodating portion 13 in the X direction and the Y direction is the length of the bottom wall 131 in the corresponding direction. An example of the depth (length in the Z direction) of the accommodating portion 13 is 0.5 mm to 2.0 mm. The depth of the accommodating portion 13 may be 0.5 mm to 1.0 mm.

As shown in FIG. 2, the open end portion 133 of the accommodating portion 13 is provided with a flange portion 14 projecting outward. The upper surface of the accommodating portion 13 and the upper surface of the flange portion 14 form the upper surface 11a of the first member 11. In the X direction, the end portion of the flange portion 14 (the end portion of the test strip TS on the sample pad 1 side) 14a may have a step lowered toward the bottom wall 131 side in the Z direction.

The second member 12 is a member that closes the opening of the accommodating portion 13, and is overlapped with the upper surface 11a of the first member 11. The region of the first member 11 facing at least the membrane 3 (result display unit) is the transparent region A. In the package 10, the opening method and the like of the package 10 (for example, as shown in FIG. 2, an arrow indicating the opening direction) may be printed in the area other than the transparent area A. The concept of transparency (at least transparency in the transparent region A) described herein may contain a small amount of color to the extent that it does not interfere with the visual inspection of the test results shown on test line L1. However, the transparency described in the present specification is preferably colorless and transparent.

In the first embodiment, as shown in FIG. 2, the transparent region A is the first member 11 except for the vicinity of the opening end side (the end portion on the sample pad 1 side) of the package 10.

As shown in FIG. 3, a seal portion is formed in a portion of the region where the first member 11 and the second member 12 overlap (hereinafter, referred to as “overlapping region”) when viewed from the Z direction, outside the test strip TS. 15 is formed. In FIG. 3, in order to clearly indicate the seal portion 15, the seal portion 15 is hatched. The seal portion 15 is formed so as to surround the accommodating portion 13. The seal portion 15 is a portion in which the first member 11 and the second member 12 are easily peeled (easily peeled off). In the first embodiment, the first member 11 and the second member 12 are heat-sealed. In FIG. 3, for convenience of explanation, the illustration of the gradation in the vicinity of the end portion shown in FIG. 2 is omitted.

FIG. 3 shows a seal portion 15 when the end portion 14a (see FIG. 2) of the flange portion 14 has a step on the bottom wall 131 side. In this form, the second member 12 does not come into contact with the first member 11 in the vicinity of the end portion 14a. Therefore, on the opening end side of the package 10, the end portion of the seal portion 15 in the X direction is located on the test strip TS side from the step portion.

The first member 11 and the second member 12 barrier the contained test strip TS, for example, water vapor, oxygen, etc. so that the external environment does not affect the contained test strip TS, and the sample supplied to the test strip TS as described later. Has a barrier property that prevents water vapor from leaking to the outside.

The first member 11 and the second member 12 will be further described with reference to FIG.

[First member]
The first member 11 is a multilayer film in which an easy peel sealant layer 21a, a transparent vapor-deposited film 21b, and a paper sheet 21c are laminated in this order from the inside of the package 10.

The easy peel sealant layer 21a is a layer for easy peeling the first member 11 and the second member 12. The easy peel sealant layer 21a is formed of a transparent easy peel sealant resin. Examples of the material of such an easy peelant resin include a blended resin of polypropylene (PP) and polyethylene (PE). An example of the thickness of the easy peel sealant layer 21a is 20 μm to 100 μm. For example, the easy peel sealant layer 21a is formed of a blended resin of PP and PE (70% PP and 30% PE), and has a thickness of 30 μm.

The transparent vapor-deposited film 21b is a functional film in which a transparent inorganic thin film is formed on a base film by a thin-film deposition process. The transparent vapor-deposited film 21b functions as the transparent barrier film having the above-mentioned barrier property. The transparent vapor-deposited film may have a coating layer further formed on the inorganic thin film. An example of the thickness of the transparent thin-film film 21b is 12 μm to 25 μm. The transparent vapor-deposited film 21b is arranged in the first member 11 so that the base film is located on the outside.

The base film is a transparent film. Examples of the material of the base film include polyethylene terephthalate (PET), stretched polypropylene (OPP: Oriented PolyPropylene), stretched polyamide (nylon) (ONY), and polybutylene terephthalate (PBT). An example of the thickness of the base film is 12 μm to 25 μm. For example, the base film is a PET film having a thickness of 12 μm.

Examples of the material of the inorganic thin film include alumina and silicon oxide.

The color of the paper sheet 21c is white. Examples of the paper forming the paper sheet 21c include bleached kraft, pure white roll, coated paper, elastic molded paper, and the like. The paper forming the paper sheet 21c may be synthetic paper such as YUPO. Examples of the basis weight of the paper sheet 21c ^is a ^{100g / m 2 ~600g / m 2} .

The first member 11 can be formed by processing a single multilayer film having the above-mentioned layer structure so as to have, for example, an accommodating portion 13. An example of the processing method is embossing. In other words, the first member 11 is an integrally molded product of the accommodating portion 13 and the flange portion 14. In the layer structure of the first member 11 shown in FIG. 4, the inside of the paper sheet 21c is transparent. Therefore, when the bottom wall 131 is viewed from the test strip TS side, the color of the bottom wall 131 is white (the color of the paper sheet 21c). ).

[Second member]
The second member 12 is a multilayer film in which a transparent resin film 21d, a transparent resin film 21e, a printing layer 21f, a transparent vapor-deposited film 21b, and a transparent resin film 21g are laminated in this order from the inside of the package 10.

The transparent resin film 21d may be formed so that the easy peel sealant layer 21a of the first member 11 and the easy peel can be formed. Examples of the material of the transparent resin film 21d include PE and unstretched polypropylene (CPP). An example of the thickness of the transparent resin film 21d is 30 μm to 150 μm. For example, the transparent resin film 21d is a PE film having a thickness of 130 μm.

The transparent resin film 21e is a film for adjusting the thickness. Examples of the material of the transparent resin film 21e include PET, OPP, ONY, and PBT. An example of the thickness of the transparent resin film 21e is 12 μm to 30 μm. For example, the transparent resin film 21e is a PET film having a thickness of 12 μm.

The print layer 21f is a layer for printing a method of opening the package 10 or the like on a portion other than the transparent region A described above. In order to make the thickness of the second member 12 uniform, the print layer 21f is formed on the entire second member 12. Therefore, transparent ink is used in the portion corresponding to the transparent region A.

The transparent vapor-deposited film 21b included in the second member 12 is the same film as the transparent vapor-deposited film 21b included in the first member 11. However, the material and thickness of the transparent vapor-deposited film 21b included in the second member 12 may be different from the transparent vapor-deposited film 21b included in the first member 11.

21 g of the transparent resin film is a film for imparting a barrier. Examples of the material of the transparent resin film 21 g include PET, OPP, ONY, and PBT. An example of the thickness of the transparent resin film 21 g is 12 μm to 25 μm. For example, 21 g of the transparent resin film is a transparent vapor-deposited PET film having a thickness of 12 μm.

Returning to FIG. 3, the seal portion 15 will be further described.

As shown in FIG. 3, the seal portion 15 has a first seal portion 15a and a second seal portion 15b. The second sealing portion 15b is located on the membrane 3 side of the sample pad 1. The first seal portion 15a is a portion of the seal portion 15 on the sample pad 1 side of the second seal portion 15b.

The second seal portion 15b is a region that is harder to peel off than the first seal portion 15a. That is, the second seal portion 15b has a peel strength stronger than the peel strength of the first seal portion 15a. The second seal portion 15b functions as a peeling stopper. An example of the peel strength of the first seal portion 15a is 1.0 N / 15 mm, and an example of the peel strength of the second seal portion 15b is 2.0 N / 15 mm. The peel strength is a peel strength measured by a test method based on JIS Z0238.

In the form shown in FIG. 3, the seal width W2 of the second seal portion 15b is wider than the seal width W1 of the first seal portion 15a. As a result, the peel strength of the second seal portion 15b is stronger than the peel strength of the first seal portion 15a.

As shown in FIG. 5, the second seal portion 15b may be a part of the region on the membrane 3 side of the sample pad 1 of the test strip TS in the seal portion 15. In this case, the portion of the seal portion 15 opposite to the first seal portion 15a when viewed from the second seal portion 15b may have a seal width sufficient to seal the test strip TS. For example, as shown in FIG. 5, the portion of the seal portion 15 on the membrane 3 side of the second seal portion 15b may be the same as the seal width of the first seal portion 15a.

In order to realize the relationship between the peel strength of the first seal portion 15a and the second seal portion 15b described above, instead of changing the seal width, the seal conditions between the first seal portion 15a and the second seal portion 15b are changed. You may. For example, when the seal portion 15 is a heat seal, the seal temperature when forming the second seal portion 15b may be different from the seal temperature when forming the first seal portion 15a. The relationship between the seal temperature and the peel strength differs depending on the material of the easy peel sealant layer 21a, but usually, the higher the seal temperature, the stronger the peel strength.

Both the seal width and the seal conditions may be adjusted in order to realize the above relationship of the peel strength of the first seal portion 15a and the second seal portion 15b.

When manufacturing the package 10, first, the test strip TS is housed in the housing section 13 and fixed to the bottom wall 131. Next, the second member 12 is superposed on the first member 11 so as to close the opening of the accommodating portion 13. In this state, the seal portion 15 is formed so as to have the first seal portion 15a and the second seal portion 15b. As a result, the package 10 is manufactured.

Next, a method for inspecting a sample by an immunochromatographic method using the package 10 will be described with reference to FIG.

First, the user peels the second member 12 from the first member 11 from the opened end (the end on the sample pad 1 side) of the package 10. Since the peel strength of the second seal portion 15b is stronger than that of the first seal portion 15a, the peeling stops at the second seal portion 15b. That is, the package 10 is partially opened. The second sealing portion 15b is located on the membrane 3 side of the sample pad 1. Therefore, the sample pad 1 is exposed from the package 10 by partially opening the package 10 as described above.

The user supplies the sample to the exposed sample pad 1. The sample (blood in the first embodiment) may be supplied directly to the sample pad 1 from, for example, the finger of the subject. After that, the peeled second member 12 is returned to the first member 11 side again, and the opening of the accommodating portion 13 is closed by the second member 12.

The seal portion 15 has a first seal portion 15a and a second seal portion 15b having a stronger peel strength than the first seal portion 15a. Therefore, as shown in FIG. 6, only a part of the second member 12 can be separated from the first member 11. As a result, after the sample is supplied to the sample pad 1, the opening of the accommodating portion 13 can be closed again with the second member 12. Further, the region of the second member 12 facing the membrane 3 is the transparent region A. Therefore, even if the opening of the accommodating portion 13 is closed with the second member 12 after the sample is supplied to the sample pad 1, the inspection result can be visually observed. After supplying the sample to the sample pad 1 (for example, when confirming the test result), the test strip TS is further covered by the second member 12 while being housed in the first member 11. Therefore, even if the test result is positive (pathogen, virus, etc. are present in the sample), secondary infection can be prevented. That is, by using the package 10, the inspection result can be safely confirmed.

The first member 11 has an accommodating portion 13, and the test strip TS is accommodated in the accommodating portion 13. The sample is supplied to the test strip TS in the container 13. Therefore, even if the upper surface 11a of the first member 11 and the second member 12 are in contact with each other, no sample is supplied between them. In this case, for example, since the sample does not move due to the capillary phenomenon between the upper surface 11a of the first member 11 and the second member 12, bleeding of the sample on and around the test strip TS can be prevented. As a result, the inspection result can be appropriately visually confirmed.

The first member 11 is a tray-shaped member having an accommodating portion 13. Therefore, for example, the package 10 is thicker than when the first member 11 is a flat film. Therefore, the package 10 is easy to handle.

The first member 11 has a white paper sheet 21c, and the inside of the first member 11 from the paper sheet 21c is a transparent member. Therefore, the color of the first member 11 is white. In this case, since the bottom wall 131 on which the test strip TS is fixed is also white, it is easy to visually confirm the color development caused by the antigen-antibody reaction.

Since the first member 11 has the paper sheet 21c, it is easy to process. Therefore, it is easy to form the first member 11 by processing one flat multilayer film including the paper sheet 21c into a tray shape. Since the first member 11 has the paper sheet 21c, the amount of the plastic material used in the first member 11 can be reduced. Therefore, the manufacturing cost of the first member 11 and the manufacturing cost of the package 10 using the first member 11 can be reduced. Further, since the amount of the plastic material used can be reduced, for example, when the package 10 is discarded after the inspection, the burden on the environment can be reduced.

When the accommodating portion 13 has the illustrated sizes (lengths in the X direction, the Y direction, and the Z direction), the test strip TS can be reliably accommodated in the accommodating portion 13, and the sample pad 1 can be easily supplied with the sample. Therefore, it is easy to prevent the sample from adhering to the upper surface 11a of the first member 11.

When the second member 12 has the illustrated thickness, since it has a certain rigidity as well as flexibility, it is easy to perform operations such as partial peeling and reclosing the partially peeled region. Further, when the second member 12 has the illustrated thickness, it is more possible to stably cover the test strip TS when the partially peeled region of the second member 12 is restored.

The second member 12 can be partially peeled from the first member 11. Therefore, for example, it is easy to selectively supply the sample to the sample pad 1 of the test strip TS. Further, since it is a partial peeling, it is easy to cover the test strip TS with the inspection again with the second member 12 after the inspection, so that the safety is improved and the ease of handling is improved.

As shown in FIG. 2, when the end portion 14a of the flange portion 14 has a step lowered toward the bottom wall 131 side of the accommodating portion 13 in the Z direction, the package 10 can be easily opened.

The layer structure of the first member 11 and the second member 12 is not limited to the form shown in FIG. A modified example of the first member 11 and the second member 12 will be specifically described.

(Modification example 1)
The first member 11 of the modified example 1 is different from the first member 11 shown in FIG. 4 in that it has a laminated structure of the first transparent resin film and a metal thin film (or metal layer) instead of the transparent vapor-deposited film 21b. do. The second member 12 of the first modification is different from the second member 12 shown in FIG. 4 in that it does not have the transparent resin film 21 g. The layer structure of the first member 11 and the second member 12 in the first modification is as follows.

[Second member]
Transparent vapor deposition film 21b / printing layer 21f / transparent resin film 21e / transparent resin film 21d
[First member]
Easy peel sealant layer 21a / first transparent resin film / metal thin film / paper sheet 21c

As described above, since the second member 12 does not have the transparent resin film 21g shown in FIG. 4, the transparent vapor-deposited film 21b is the outermost layer on the front side of the package 10.

In the first modification, the thickness of the easy peel sealant layer 21a included in the first member 11 may be thicker than the thickness of the easy peel sealant layer 21a illustrated in FIG. The thickness of the easy peel sealant layer 21a of the first modification is, for example, 50 μm.

Examples of the material of the first transparent resin film included in the first member 11 include PET, PE, and CPP. An example of the thickness of the first transparent resin film is 12 μm to 100 μm. For example, the first transparent resin film is a PET film having a thickness of 12 μm.

Examples of the material of the metal thin film included in the first member 11 include aluminum (Al). The thickness of the metal thin film is such that the paper sheet 21c has a visible transparency, for example, 7 μm to 30 μm. For example, the metal thin film is an aluminum thin film having a thickness of 20 μm.

In the first modification, the first member 11 has a barrier property due to the laminated structure of the first transparent resin film and the metal thin film (or metal layer). Also in the first modification. Of the first member 11, the inside of the paper sheet 21c is a transparent member. Therefore, the color of the first member 11 as seen from the test strip TS side is white.

(Modification 2)
The first member 11 of the second modification is different from the first member 11 shown in FIG. 4 in that it has a transparent resin film 21d instead of the easy peel sealant layer 21a. The second member 12 of the second modification is different from the second member 12 shown in FIG. 4 in that it has an easy peel sealant layer 21a instead of the transparent resin film 21d. Modification 2 will be described focusing on this difference. The layer structure of the first member 11 and the second member 12 in the second modification is as follows.

[Second member]
Transparent resin film 21g / transparent vapor deposition film 21b / printing layer 21f / transparent resin film 21e / easy peel sealant layer 21a
[First member]
Transparent resin film 21d / transparent vapor deposition film 21b / paper sheet 21c

The thickness of the easy peel sealant layer 21a included in the second member 12 of the second modification may be thicker than that of the easy peel sealant layer 21a included in the first member 11 shown in FIG. For example, the thickness of the easy peel sealant layer 21a of Modification 2 is 50 μm. The thickness of the transparent resin film 21d of the first member 11 of the modified example 2 may be thinner than that of the transparent resin film 21d of the second member 12 shown in FIG. For example, the thickness of the transparent resin film 21d of Modification 2 is 30 μm.

Also in the second modification, the inside of the first member 11 from the paper sheet 21c is a transparent member. Therefore, the color of the first member 11 as seen from the test strip TS side is white.

(Modification example 3)
The first member 11 of the modified example 3 has a laminated structure of the first transparent resin film and the metal thin film (or metal layer) described in the modified example 1 instead of the transparent vapor-deposited film 21b. The second member 12 of the modified example 3, which is different from the member 11, is different from the second member 12 of the modified example 2 in that it does not have the transparent resin film 21e. Modification 3 will be described focusing on this difference. The layer structure of the first member 11 and the second member 12 in the modified example 3 is as follows.

[Second member 12]
Transparent resin film 21g / transparent vapor deposition film 21b / printing layer 21f / easy peel sealant layer 21a
[First member 11]
Transparent resin film 21d / first transparent resin film / metal thin film / paper sheet 21c

The thickness of the transparent resin film 21d of the first member 11 of the modified example 3 may be thicker than the thickness of the transparent resin film 21d of the first member 11 of the modified example 2. For example, in the third modification, the thickness of the transparent resin film 21d included in the first member 11 is 50 μm.

Also in the first modification, the first member 11 has a barrier property due to the laminated structure of the first transparent resin film and the metal thin film (or metal layer). Also in variant 3. Of the first member 11, the inside of the paper sheet 21c is a transparent member. Therefore, the color of the first member 11 as seen from the test strip TS side is white.

(Second Embodiment)
FIG. 7 is an exploded perspective view of the package according to the second embodiment. FIG. 8 is a cross-sectional view for explaining the package 10A shown in FIG. 7, and shows an example of a cross section orthogonal to the extending direction of the package 10A. The package 10A shown in FIGS. 7 and 8 is mainly different from the package 10 in that the first member 11A is provided instead of the first member 11. The second embodiment will be described focusing on this difference. Also in the second embodiment, the same X-direction, Y-direction, and Z-direction as in the first embodiment may be used for description.

The first member 11A has a plate 16 and a back sheet 17. The back sheet 17 is joined to the back surface 16a of the plate 16. The plan view shape (shape seen from the Z direction) of the plate 16 and the back sheet 17 may be the same. In the second embodiment, the color of the back sheet 17 is white when viewed from the test strip TS side.

A through hole 161 is formed in the plate 16. In the first member 11A, as shown in FIG. 8, the inner wall surface 161a and the back sheet 17 of the through hole 161 form an accommodating portion 13A in which the test strip TS is accommodated.

The accommodating portion 13A has a bottom wall 131 formed in a region of the back sheet 17 surrounded by the through hole 161 and a side peripheral wall 132 formed by the inner wall surface 161a of the through hole 161.

The example of the size of the accommodating portion 13A is the same as the example of the size of the accommodating portion 13 described in the first embodiment. Therefore, the example of the thickness (length in the Z direction) of the plate 16 is the same as the example of the depth of the accommodating portion 13 described in the first embodiment. Examples of the lengths of the through holes 161 in the X direction and the Y direction are the same as the lengths of the accommodating portions 13 described in the first embodiment in the corresponding directions.

The plate 16 is a resin plate. Examples of materials for the plate 16 are olefin resins such as PE, polypropylene (PP), cycloolefin polymer (COP).

The second member 12 is arranged on the upper surface of the plate 16 so as to close the opening of the accommodating portion 13A. The second member 12 is easily peelable from the first member 11 (specifically, the plate 16) so as to surround the accommodating portion 13A. Also in the second embodiment, the package 10A has the seal portion 15 described in the first embodiment. In the second embodiment, the thickness of the plate 16 is uniform, and the upper surface (the surface on the second member 12 side) of the plate 16 is flat. Therefore, the seal portion 15 is formed on the peripheral edge portion of the overlapping region between the upper surface of the plate 16 and the second member 12 (the upper surface of the plate 16 and the peripheral edge of each of the second member 12). As in the case of the first embodiment, the plate 16 may have a step (a step lowered to the back sheet 17 side) on the opening end side.

The first member 11 and the second member 12 will be further described with reference to FIG.

As described above, the plate 16 included in the first member 11 is a resin plate. The plate 16 is, for example, 700 μm thick and is a plate made of PP or PE.

The back sheet 17 is a multilayer film in which a transparent resin film 21h, a printing layer 21f, a transparent vapor-deposited film 21b, and a transparent resin film 21i are laminated in this order from the test strip TS side.

Examples of the material of the transparent resin film 21h include CPP and PE. An example of the thickness of the transparent resin film 21h is 100 μm to 1000 μm. The material of the transparent resin film 21h may be selected so that it can be easily bonded to the plate 16.

For example, when the material of the plate 16 is PP, the material of the transparent resin film 21h is CPP. In this case, for example, the transparent resin film 21h is a CPP film having a thickness of 60 μm. For example, when the material of the plate 16 is PE, the material of the transparent resin film 21h is, for example, PE. In this case, for example, the transparent resin film 21h is a PE film having a thickness of 60 μm.

The print layer 21f of the back sheet 17 is a layer formed of white ink. The print layer 21f is formed on the entire back sheet 17 in order to make the thickness of the back sheet 17 uniform. In the print layer 21f, for example, the region of the back sheet 17 corresponding to the bottom wall 131 of the accommodating portion 13 is formed of white ink, and the other region is, for example, ink for displaying the opening method of the package 10 or the like. It may be formed of transparent ink or the like.

Since the transparent resin film 21h is arranged inside the printing layer 21f, by using white ink for the printing layer 21f as described above, the color of the bottom wall 131 of the accommodating portion 13A can be changed to the test strip TS side. It is white when viewed from the outside.

The transparent resin film 21i is a film for adjusting the thickness. Examples of the material of the transparent resin film 21i include PET, OPP, ONY, and PBT. An example of the thickness of the transparent resin film 21i is 12 μm to 100 μm. For example, the transparent resin film 21i is a PET film having a thickness of 25 μm.

The second member 12 is a multilayer film in which an easy peel sealant layer 21a, a transparent resin film 21e, a transparent vapor-deposited film 21b, a printing layer 21f, and a transparent resin film 21g are laminated in this order from the test strip TS side (first member 11 side). Is. Therefore, the second member 12 shown in FIG. 8 has the same configuration as the second member 12 of the second modification in the first embodiment. The thickness of the easy peel sealant layer 21a of the second embodiment is, for example, 50 μm.

The package 10A of the second embodiment is different in that it has the first member 11A instead of the first member 11, and the other configurations are substantially the same as those of the package 10. Further, the first member 11A has an accommodating portion 13A like the first member 11 of the first embodiment. Therefore, the package 10A has at least the same effect as the package 10.

In the second embodiment, since the first member 11A has the plate 16, the entire package 10A is thick. Therefore, the handling of the package 10A is easier.

Next, a modification of the first member 11 and the second member in the second embodiment will be described.

(Modification example 4)
The first member 11 of the modified example 4 is different from the first member 11 shown in FIG. 8 in that the back sheet 17 is a synthetic paper sheet. The second member 12 of the modified example 4 is a transparent resin film 21e. It differs from the second member 12 shown in FIG. 8 in that it is arranged between the transparent resin film 21 g and the transparent vapor-deposited film 21b. A modified example 4 will be described focusing on this difference.

In the fourth modification, the first member 11A is a synthetic paper sheet. The first member 11A may be a synthetic paper sheet that is white and has a barrier property. For example, the first member 11A is YUPO. The basis weight of the synthetic paper sheet may be the same as that of the paper sheet 21c described in the first embodiment.

The layer structure of the second member 12 in the modified example 4 is as follows. In the following layer structure, the easy peel sealant layer 21a side is inside the package 10A.
Easy peel sealant layer 21a / printing layer 21f / transparent vapor deposition film 21b / transparent resin film 21e / transparent resin film 21g

Since the second member 12 is the same as the second member 12 shown in FIG. 8 except that the position of the transparent resin film 21e is different, the description of each layer will be omitted.

In the fourth modification, the plate 16 may be thicker than the case shown in FIG. For example, the plate 16 in the fourth modification is a plate having a thickness of 800 μm and formed of PP.

(Third Embodiment)
FIG. 9 is an exploded perspective view of the package 10B according to the third embodiment. FIG. 10 is a plan view of the package 10B shown in FIG. The package 10B differs from the package 10 of the first embodiment in that it has a second member 12A instead of the second member 12 and further has a cover 18. Package 10B will be described focusing on the differences. Also in the third embodiment, the same X direction, Y direction and Z direction as in the first embodiment may be used for description.

The second member 12A is different from the second member 12 in that a through hole 121 for supplying a sample is formed. Other configurations are the same as those of the second member 12, and the second member 12A has a transparent region A. The through hole 121 is a hole for supplying a sample to the sample pad 1, and is formed on the sample pad 1. The shape of the through hole 121 has a shape capable of supplying a sample to the sample pad 1. The through hole 121 may be, for example, an elongated hole extending in the X direction, or may be a perfect circle or an ellipse. Alternatively, the through hole 121 may have a rectangular shape (for example, a rectangle or a square) when viewed from the Z direction.

The second member 12A is overlapped with the first member 11, and a seal portion 15A (see FIG. 10) is formed in a portion of the overlapping region of the first member 11 and the second member 12A outside the accommodating portion 13. ing. The seal portion 15A surrounds the accommodating portion 13. In the third embodiment, the seal width of the seal portion 15A may be constant over the entire seal portion 15A.

The layer structure of the first member 11 and the second member 12A may be the same as that of the first embodiment and its modifications.

The cover 18 is a member that closes the through hole 121, and has the same barrier properties as the first member 11 and the second member 12. The cover 18 is removable from the second member 12. The cover 18 has a shape (including size) capable of closing the through hole 121. An example of the thickness of the cover 18 is 12 μm to 100 μm.

The cover 18 has a base film and an adhesive layer formed on the base film. The base film is a resin film having a barrier property and supports the adhesive layer. Examples of the material of the base film include PET, OPP, and YUPO paper. Examples of the material of the adhesive layer include acrylic or urethane adhesives having an adhesive strength of 1N / 15 mm to 5N / 15 mm. A tab 181 may be formed on the cover 18 as shown in FIG. 9 in order to facilitate the attachment / detachment of the cover 18.

When the test by immunochromatography is performed using the test strip TS contained in the package 10B, the cover 18 is peeled off from the package 10B to expose the through hole 121. The sample is supplied to the sample pad 1 through the exposed through hole 121. After that, the cover 18 is reattached to the second member 12A to close the through hole 121.

As described above, in the package 10B, the sample can be supplied to the sample pad 1 through the through hole 121 by peeling the cover 18 from the second member 12A. Further, by closing the through hole 121 with the cover 18, the entire test strip TS can be included in the package 10B. Further, the first member 11 has a housing portion 13 as in the first embodiment. Therefore, the package 10B has at least the same effect as the package 10 of the first embodiment.

The first member 11 may be the same as the first member 11A described in the second embodiment and its modification. In this case, the package according to the third embodiment has the same effect as the package 10A of the second embodiment.

Although various embodiments of the present invention have been described above, the present invention is not limited to the above-described embodiments.

The first member and the second member are configured so as to be easily peelable, have a barrier property, the first member has an accommodating portion, and a region of the second member facing the result display portion is formed. The configurations of the first member and the second member are not limited to the illustrated configurations as long as the transparent region is satisfied. For example, the first member and the second member do not have to have a print layer. Of the first member, the bottom wall of the accommodating portion may be transparent instead of white. The first member does not have to have a paper sheet (for example, a white paper sheet). The first member and the second member may have a transparent barrier film for ensuring the barrier property.

The package of the third embodiment is also removable to the second member, and its configuration is not limited as long as it has a barrier property.

The second member in the first embodiment and the second embodiment may have an adhesive layer inside the package. In this case, when the second member is returned to the original with respect to the first member after the sample is supplied to the sample supply unit, it is easy to stably maintain the state of covering the entire test strip.

In the third embodiment, the cover may be sufficiently longer in the X direction than the sample supply through hole formed in the second member. In this case, for example, similarly to the second member in the first embodiment and the second embodiment, a part of the cover may be peeled off from the second member to expose the through hole for sample supply.

The various embodiments and modifications exemplified may be appropriately combined without departing from the spirit of the present invention.

1 ... Sample pad (sample supply unit), 3 ... Membrane (result display unit), 10,10A, 10B ... Package, 11,11A ... 1st member, 12,12A ... 2nd member, 13,13A ... Storage unit, 14 ... Flange portion, 15, 15A ... Seal portion, 15a ... First seal portion, 15b ... Second seal portion, 16 ... Plate, 16a ... Back surface, 17 ... Back sheet, 18 ... Cover, 121 ... Through hole (second) Through holes formed in the members), 131 ... bottom wall (bottom wall of the accommodating portion), 132 ... side peripheral wall (side peripheral wall of the accommodating portion) 133 ... open end (end), 161 ... through hole (on the plate) Formed through hole), 161a ... Inner wall surface (inner wall surface of through hole), A ... Transparent area, TS ... Test strip.

Claims (9)

A package containing a test strip including a sample supply unit on which a sample to be inspected by an immunochromatography method is dropped and a result display unit showing the test results of the sample dropped on the sample supply unit.
A first member having an accommodating portion including a bottom wall on which the test strip is placed and a side peripheral wall surrounding the test strip.
A second member provided on the first member and including the test strip together with the first member, and a second member.
With
The region of the second member facing the result display portion of the test strip is a transparent region.
In the outer portion of the overlapping region between the first member and the second member, a sealing portion in which the first member and the second member are sealed so as to surround the accommodating portion is provided. Has been formed and
The seal portion has a first seal portion and a second seal portion having a stronger peel strength than the first seal portion.
The second seal portion is formed on the result display portion side of the sample supply portion of the test strip.
The first seal portion is a portion of the seal portion on the sample supply portion side with respect to the second seal portion.
package. The seal width of the second seal portion is longer than the seal width of the first seal portion.
The package according to claim 1. A package containing a test strip including a sample supply unit on which a sample to be inspected by an immunochromatography method is dropped and a result display unit showing the test results of the sample dropped on the sample supply unit.
A first member having an accommodating portion including a bottom wall on which the test strip is placed and a side peripheral wall surrounding the test strip.
A first member arranged to face the first member, and a second member having a through hole for supplying the sample formed at a position facing the sample supply unit.
A cover that closes the through hole and is removable from the second member,
With
In the second member, the region facing the result display unit is a transparent region.
In the outer portion of the overlapping region between the first member and the second member, a sealing portion in which the first member and the second member are sealed so as to surround the accommodating portion is provided. Is formed,
package. The color of the bottom wall of the housing portion corresponding to the result display portion when viewed from the test strip side is white.
The package according to any one of claims 1 to 3. The bottom wall of the housing contains a white paper sheet.
The package according to claim 4. The first member is
With the storage part
A flange portion provided at the end of the accommodating portion on the second member side, and a flange portion.
Have,
The package according to any one of claims 1 to 3. The first member is an integrally molded product of the accommodating portion and the flange portion.
The first member includes a white paper sheet.
The package according to claim 6. The first member is
With the plate
The back sheet joined to the back surface of the plate and
Have,
The plate is formed with a through hole having an inner wall surface forming a side peripheral wall of the accommodating portion.
The accommodating portion is formed by the inner wall surface of the through hole and the back sheet.
The package according to any one of claims 1 to 3. The back sheet includes a white paper sheet.
The package according to claim 8.

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