JP2021101967A - Radioactive pharmaceutical administration device, radioactive pharmaceutical administration method and radioactive pharmaceutical administration program - Google Patents

Abstract

To provide a technique for administering radioactive pharmaceuticals for a large number of people stored in a plurality of containers.SOLUTION: A radioactive pharmaceutical administration device comprises a motor which drives in the first operation mode of operating so as to feed a portion of a radioactive pharmaceutical 67 stored in a vial 74 to tube parts 31b, 31c and in the second operation mode of mixing the radioactive pharmaceutical extracted from another vial with at least a portion of a stored pharmaceutical.SELECTED DRAWING: Figure 3

Description

The present invention relates to a radiopharmaceutical administration device, a radiopharmaceutical administration method, and a radiopharmaceutical administration program.

Radiopharmaceuticals may be administered to a subject using a dosing device to prevent exposure to health care workers. Examples of such an administration device include those described in Patent Document 1.

Japanese Unexamined Patent Publication No. 2008-253409

However, in the administration device, the installation portion of the container for accommodating the radioactive drug has a predetermined shape and size in advance. Therefore, the radiopharmaceutical produced according to the number of subjects to be administered must be contained in a container sized to be installed in the administration device. Therefore, when a larger amount of radioactive drug than can be accommodated in a container that can be installed in the administration device is required, it is necessary to prepare the radioactive drug by dividing it into a plurality of containers.

The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a technique for administering a radiopharmaceutical for a large number of people contained in a plurality of containers.

The radiopharmaceutical administration device of the present invention has a first operation mode in which a part of the radiopharmaceutical contained in the first vial is sent to the administration flow path, and the first vial after the first operation mode. It has a drive unit driven by a second operation mode in which the remaining radioactive agent contained in the first vial and at least a part of the radioactive agent contained in the second vial different from the first vial are combined.

In addition, the radiopharmaceutical administration device of the present invention includes a dose acquisition unit that acquires the dose of the radiopharmaceutical to be administered to one subject, and the radioactivity amount of the radiopharmaceutical contained in one vial. A determination unit that compares the radioactivity amount and the dose to determine the necessity of an instruction from a medical worker, and the determination unit needs an instruction from the medical worker. When it is determined, it has a display unit for displaying a message to a medical worker, and the dose acquisition unit has a first dose to be administered to the first subject and the first subject. A second dose, which is the dose of the second subject to be administered after the examiner, is obtained, and the determination unit is housed in the vial after administration to the first subject. The remaining amount of the radiopharmaceutical is compared with the second dose, and when the remaining amount of the radiopharmaceutical is less than the second dose, the remaining amount of the radioactivity is added to the second dose. Display a message as to whether or not to include.

The method for administering a radiopharmaceutical of the present invention is a method for administering a radiopharmaceutical executed by an apparatus for administering a radiopharmaceutical, and is a first step of sending a part of the radiopharmaceutical contained in the first vial to an administration channel. After the first step, at least the radioactive drug that was not sent from the first vial to the administration channel in the first step and the radioactive drug contained in the second vial different from the first vial. A method for administering a radiopharmaceutical, which comprises a second step of sending a part together to the administration flow path.

In addition, the method for administering a radiopharmaceutical of the present invention is a method for administering a radiopharmaceutical that is executed by a device for administering a radiopharmaceutical, and includes a step of obtaining a dose of the radiopharmaceutical to be administered to a subject. The step of acquiring the radioactivity amount of the radiopharmaceutical contained in one vial, the step of comparing the radioactivity amount with the dose, and the step of determining the necessity of instruction from a medical worker, and the determination unit In the step of obtaining a dose, which includes a step of displaying a message to the medical worker when it is determined that an instruction from the medical worker is necessary, a first method to be administered to the first subject is given. In the step of obtaining the dose and the second dose, which is the dose of the second subject to be administered after the first subject, and determining the necessity of instructions from the medical personnel. After administration to the first subject, the remaining amount of the radiopharmaceutical remaining in the vial after administration to the first subject is compared with the second dose to determine the balance. A method for administering a radiopharmaceutical, which displays a message as to whether or not the remaining amount is included in the second dose when the amount is less than the second dose.

The radiopharmaceutical administration program of the present invention is a radiopharmaceutical administration program for causing the radiopharmaceutical administration apparatus to execute the above-mentioned radiopharmaceutical administration method.

The present invention can provide a radiopharmaceutical administration device that administers radiopharmaceuticals for a large number of people contained in a plurality of containers.

It is a schematic diagram for demonstrating the outline of this invention. It is a perspective view of the administration apparatus of the radioactive agent of 1st Embodiment of this invention. It is a figure which shows the vertical cross section of the structure which concerns on the extraction and administration of the radioactive drug provided in the administration apparatus shown in FIG. It is a schematic diagram for demonstrating the administration procedure of the radioactive agent of 1st Embodiment of this invention. It is a functional block diagram for demonstrating the control apparatus which executes the extraction control program of 1st Embodiment of this invention. It is a flowchart for demonstrating the extraction method of the radioactive agent executed by the control device shown in FIG. It is a figure for demonstrating the radiopharmaceutical administration apparatus of the 2nd Embodiment of this invention.

Hereinafter, the first embodiment and the second embodiment of the present invention will be described. In the first embodiment and the second embodiment, the same members are designated by the same reference numerals. Further, the drawings of the first embodiment and the second embodiment show an example of the radiopharmaceutical administration device, the radiopharmaceutical extraction method, and the radiopharmaceutical extraction control program of the present invention, and show specific configurations thereof. It is not limited.
[Overview]
First, an outline of the present invention will be described prior to the description of the first embodiment and the second embodiment.
FIG. 1 is a schematic view for explaining the outline of the present invention, and shows the amount a of the radiopharmaceutical R contained in one vial. The arrow line in FIG. 1 indicates the time axis, and the time t1, the time t2, and the time t3 all indicate the time when the planned use (administration) of the radiopharmaceutical R is started. For example, the radiopharmaceutical R is set to have a radioactivity amount of 185 Mbq at the time t2 as the test time. The test time is a time for guaranteeing that the radiopharmaceutical has a predetermined amount of radioactivity after the production of the radiopharmaceutical.
Here, the quantity a will be 2 mL, the time t1 will be 9:30, the time t2 will be 10:00, and the time t3 will be 10:30. Further, in the explanation of FIG. 1, it is assumed that the weights of the subjects who receive the radiopharmaceutical R at the time t1, the time t2, and the time t3 are all equal. The radiopharmaceutical R has a radioactivity amount equal to or higher than the optimum radioactivity amount (hereinafter, also referred to as an optimum dose) in any of 9:30 to 10:00. The optimum dose refers to the amount of radioactivity capable of taking an image having a resolution sufficient for the examination and without overexposure, and is 185 MBq here.

At 9:30, the radioactivity of the radiopharmaceutical R is greater than 185 MBq. Therefore, in the administration started at 9:30, only the amount a1 corresponding to the optimum dose of the amount a can be administered, and the remaining amount a2 can be temporarily stored for the examination. In the administration starting at 10:00, the test is performed by administering the radiopharmaceutical in a dose a to the subject as scheduled.
If the administration scheduled at 10:30 is to be performed at 10:50 due to some delay in the schedule, for example, the amount of radioactivity of the radiopharmaceutical R may be attenuated and the amount of liquid required for the test may not be secured. There is sex. In such a case, the amount of radioactivity of the radiopharmaceutical in the amount a2 also decreases between 9:30 and 10:50, but the amount required for the test can be added by adding it to the radiopharmaceutical R used for this administration. There is a possibility of securing the radiopharmaceutical R.

When the amount of the radiopharmaceutical R to be administered is insufficient, conventionally, the resolution taken for the test is lowered and the reliability of the test is impaired. In order to avoid this, it was necessary to order the radiopharmaceutical again and perform the inspection. However, if the optimum dose of the radiopharmaceutical R is secured as described above, an image having the resolution required for the inspection can be obtained without ordering a new radiopharmaceutical R.

The description given in FIG. 1 is a concept of the present invention. The specific administration procedure of the present invention is to administer a part of the radiopharmaceutical contained in one vial (first vial) to the subject, and then the radioactivity that was not sent to the administration channel. The radiopharmaceutical contained in another vial (second vial) together with the drug (residual radiopharmaceutical) may be administered to another subject. Therefore, in the present invention, for example, after extracting the radioactive agent in the amount a1 from the first vial and administering it to the first subject, the amount a2 remaining in the first vial is extracted and the first vial. Administer to the second subject. Then, the first vial is replaced with the second vial, and the radiopharmaceutical in the amount a1 is extracted from the radiopharmaceutical contained in the second vial and administered to the second subject. In addition, the amount a2 of the radiopharmaceutical remaining in the second vial is extracted and administered to the third subject. Further, the second vial may be replaced with a third vial, and the entire amount of the radiopharmaceutical in the amount a contained in the third vial may be administered to the third subject.

Further, the present invention may temporarily store all of the residual radiopharmaceutical of the radiopharmaceutical in the first vial in a containment (not shown). Such an accommodating portion may be provided inside the administration device such as a syringe, or may be provided outside the administration device. The radiopharmaceutical in the first vial contained in the container is administered in combination with a second vial different from this first vial, or a part or all of the radiopharmaceutical contained in the third vial. It may be done.

[First Embodiment]
(Radioactive drug administration device)
Next, the radiopharmaceutical administration device of the first embodiment will be described. In the first embodiment and the second embodiment, the radiopharmaceutical administration device is also simply referred to as “administration device”.
2 and 3 are views for explaining the administration device 1 of the first embodiment, and FIG. 2 is a perspective view of the administration device 1. FIG. 3 is a view showing a vertical cross section of a configuration related to extraction and administration of a radioactive drug provided inside the administration device 1 shown in FIG. 2, in which the administration device 1 is cut along the x-z plane in FIG. Is shown.

The radiopharmaceutical is a liquid, and the type thereof is not particularly limited. Examples of such radiopharmaceuticals include radiopharmaceuticals containing positron-releasing nuclei (fluorine-18, nitrogen-13, carbon-11, copper-64, etc.) for PET (Positron Emission Tomography) inspection. [ ¹⁸ F] -2-deoxy-2-fluoro-D-glucose), [ ¹⁸ F] flutemetamol, [ ¹⁸ F] fluorobetapill, [ ¹⁸ F] fluorobetaben, [ ¹⁸ F] flucyclobin, [ ¹⁸ F] fluoroethyl tyrosine , [ ¹⁸ F] Fluoromisonidazole, [ ¹⁸ F] Dopamine, [ ¹⁸ F] Fluorine Sodium, [ ¹¹ C] Methionin, [ ¹¹ C] Choline Derivatives, [ ¹¹ C] Acetic Acid, [ ⁶⁴ Cu] Dithiosemicarba Zone derivatives and the like, as well as radioactive nuclei for SPECT (Single Photon Emission Computed Tomography) inspection (Technetium-99m, Tallium-201, Gallium-67, Chromium-51, Iodine-123, Examples thereof include radiopharmaceuticals containing (iodine-125, etc.) or radiopharmaceuticals containing radionuclear species (iodo-131, etc.) for internal radiation therapy.

The administration device 1 has a configuration for extracting and administering a radioactive drug in the device housing 20. The device housing 20 is configured to reduce radiation leakage to the outside, and a shielding region is formed inside by a shielding door pair 10 composed of a shielding door 10a and a shielding door 10b. The shielding door 10b has a grip portion 11, and an operator can grip the grip portion 11 to open or close the shielding door 10b.

Further, as shown in FIG. 2, a power switch 164 for switching power on / off is provided on the front surface of the device housing 20. An operation unit 6 for instructing the operator to automatically administer the radiopharmaceutical is provided in front of the top surface of the device housing 20, and the operation unit 6 is administered information on the radiopharmaceutical, information on the administration of the radiopharmaceutical, and the radiopharmaceutical. Display biological information, etc. Further, the administration device 1 is provided with a display 165 such as a touch panel on the upper surface, which receives input by an operator. An emergency stop switch 62 for stopping the operation of the administration device 1 in an emergency is provided in front of the upper surface of the device housing 20, and the radioactive drug is pushed out behind the emergency stop switch 62 on the upper surface. Alternatively, a suspension base 350 is provided on which the raw food bag 3 containing the physiological saline solution for cleaning the flow path can be suspended. A tube portion 31d is connected to the saline bag 3, and the tube portion 31d is guided to the inside of the device housing 20.
The administration device 1 is configured to specify the test date, concentration, liquid volume, etc. for each vial of the radiopharmaceutical by accepting input of information about the radiopharmaceutical such as lot number.

As shown in FIG. 3, the administration device 1 of the first embodiment is arranged in the device housing 20 by attaching a configuration related to extraction and administration of a plurality of radioactive agents to the detachable cassette 110. The detachable cassette 110 is composed of a main board 111 and a sub board 121, and syringes 34 and 36 are held in the main board 111. Needle bases 21a and 21b are provided on the sub-board 121. The sub-board 121 is fixed to the main board 111 and is arranged vertically.
The extraction needle 26 is detachably held on the needle base 21a. A needle body 29 is fixed to the extraction needle 26, and the extraction needle 26 is configured to be movable up and down along the needle base 21a. The air delivery needle 30 is detachably held on the needle base 21b. A needle body 29 is fixed to the air delivery needle 30, and the air delivery needle 30 is configured to be movable up and down along the needle base 21b.

Further, a container arranging portion 64 is provided in the device housing 20. In the container arrangement portion 64, a shielding container 66 further containing a vial 74 containing a radioactive agent 67 is arranged. The container arranging portion 64 is supported by a drawer unit 73 that can be pulled out sideways (for example, to the right) from the main body portion 20a of the device housing 20. An RI detector 65 is provided above the shielding container 66, measures the radiation dose of the radiopharmaceutical 67 in the vial 74, and outputs a signal indicating the radioactivity dose (Bq).

A tube 31 that communicates with the shielding container 66 to form an administration flow path for the radioactive drug 67 is attached to the main substrate 111. In FIG. 3, the tube 31 is divided into a tube portion 31a and a tube portion 31d. Of these, in the first embodiment, the tube portion 31b and the tube portion 31c serve as the administration flow path. Further, the main substrate 111 is provided with flow path switching portions 33a, 33c, 33d provided in the administration flow path. The syringe 34 is a syringe for extracting the radioactive drug 67 from the shielding container 66 through the administration flow path. The syringe 36 is a syringe for administering the extracted radioactive drug 67 to the subject through the tube portions 31b and 31c. Both the syringe 34 and the syringe 36 are configured to include a syringe body 39 that stores the radioactive drug 67, and a plunger portion 37 that is connected to the syringe body 39 and can be pushed into the syringe body 39. Syringe drive units 55a and 55c for driving the plunger unit 37 are attached to the main substrate 111. Further, an air vented filter 32 and a tube holding portion 13 for holding the tube 31 are attached to the main substrate 111.

The flow path switching portions 33a, 33c, 33d are held by the switching member holding portion 14 and attached to the main board 111, and the syringes 34 and 36 are held by the syringe holding portion (not shown) on the main board 111, and the device housing 20 It is attached to the door so that it can be attached and detached.
A guide hole 56 for guiding the vertical movement of the syringe driving portions 55a and 55c is formed in the main board mounting base portion 51 of the apparatus housing 20 so as to extend vertically.

Inside the device housing 20, a syringe shielding cover 68 capable of covering the front, left and right sides, above and below of the syringe 36 is provided. The syringe shielding cover 68 is made of a radiation shielding material such as lead. Such a syringe shielding cover 68 is provided in consideration of holding the radioactive agent in the syringe 36 for a relatively long time in the device housing 20.

In the first embodiment, a three-way stopcock is used for the flow path switching portions 33a, 33c, 33d. The three-way stopcock can be rotationally driven by a motor M (FIG. 5) or an actuator (hereinafter, also referred to as a drive unit) to arbitrarily connect and detach the tube 31 and the syringes 34 and 36. However, the flow path switching portion of the first embodiment is not limited to the three-way stopcock, and may be any structure as long as it can switch between the tube 31 and the syringes 34 and 36. ..

The main substrate 111 is formed with openings 16a and 16c, and a part of the syringe driving portions 55a and 55c protrudes forward through the openings 16a and 16c and is connected to the plunger portions 37 of the syringes 34 and 36, respectively. .. Further, the main board 111 is provided with a handle 17, and an operator can attach the detachable cassette 110 to the device housing 20 by holding the handle 17.

The above configuration operates as follows when the vial 74 contains a radiopharmaceutical in excess of the amount of radioactivity to be administered. That is, first, the air delivery needle 30 and the extraction needle 26 are lowered and punctured by a plug body (not shown) of the vial 74, and the inside of the vial 74 and the tube portion 31a communicate with each other. At this time, the flow path switching portion 33a is rotated by a mechanism composed of a motor (motor M in FIG. 5) and an actuator (hereinafter, also referred to as a drive portion) to communicate the tube portion 31a with the inside of the syringe 34. The syringe driving unit 55a drives the plunger unit 37 of the syringe 34 to extract the radioactive drug 67 from the vial 74.

The syringe drive unit 55a is driven by the drive unit. The driving amount of the syringe driving unit 55a is determined by converting the radioactive amount of the radioactive agent 67 to be extracted into a liquid amount. In the first embodiment, the motor M shown in FIG. 5 is schematically shown as a drive unit for the syringe drive units 55a and 55c and the three-way stopcock, but the drive unit is provided separately for each drive target. May be good.

The syringe driving unit 55c drives the plunger unit 37 to draw the radioactive drug 67 extracted into the syringe 34 into the syringe 36. The driving amount of the syringe driving unit 55c is determined according to the liquid amount of the radioactive drug drawn in. After the radiopharmaceutical is drawn into the syringe 36, the flow path switching portions 33c and 33d are switched so as to block between the syringe 34 and the syringe 36 and to connect the syringe 36 and the tube portions 31b and 31c. Next, the driving unit drives the syringe driving unit 55c to push the plunger unit 37 into the syringe body 39, so that the radioactive drug 67 in the syringe 36 is administered to the subject through the tube unit 31c.

Next, the process of administering the radiopharmaceutical to a plurality of subjects while exchanging the vials 74 will be described.
FIG. 4 is a schematic diagram for explaining the administration procedure of the radiopharmaceutical in the above case. FIG. 4 shows an example in which two vials 74a and 74b are used to administer the radiopharmaceutical 67 to a plurality of subjects. Each of the vials 74a and 74b contains the radioactive agent 67, which is contained in the shielding container 66, is exchanged one by one, and is set in the container arrangement portion 64 in the device housing 20. By reading the barcode attached to the shielding container 66, product information such as the verification date and time, the radioactivity concentration, and the liquid amount of the radiopharmaceutical contained in each of the vials 74a and 74b can be specified. Therefore, the administration device 1 can specify how much liquid amount of the radiopharmaceutical contained in each vial should be extracted with respect to the amount of radioactivity to be administered to the subject.
The administration device 1 of the first embodiment includes a control device 8 (FIG. 5) for controlling the above operation inside or outside the device housing 20. The read product information is stored by the control device 8. Such a control device 8 is configured as a computer that operates a program for controlling the administration device 1. The computer may be an arithmetic unit dedicated to controlling the administration device 1, or may be a general-purpose computer. The control device 8 will be described in detail later with reference to FIG.

The administration device 1 compares the amount of radioactivity of the radiopharmaceutical contained in the vial 74a with the amount of radioactivity to be administered received by the operating unit 6, and the amount of radioactivity of the radiopharmaceutical 67 contained in the vial 74a should be administered. When the amount of radioactivity is higher than the amount of radioactivity, the air delivery needle 30 and the extraction needle 26 move in the −Y direction, that is, descend and are pierced by a plug body (not shown) of the vial 74a to extract a part of the radioactive agent 67 in the vial 74a. .. Then, the extracted radioactive drug 67 is housed in the syringe 34, and the flow path switching portions 33a, 33c, 33d are switched so that the syringe 34, the syringe 36 and the tube portions 31b, 31c communicate with each other. The syringe driving unit 55c drives and pushes the plunger unit 37, and the radioactive drug 67 stored in the syringe 36 is administered to the subject via the tube portions 31b and 31c.

After administration of the radiopharmaceutical, the air delivery needle 30 and the extraction needle 26 are in a state where a part including the tip of the needle body 29 is in the vial 74a. When the administration device 1 receives the amount of radioactivity to be administered to the next subject (second subject) through the operation unit 6, the control device 8 receives the remaining amount of radioactivity contained in the vial 74a and the second. Compare with the amount of radioactivity to be administered to the subject. If it is determined that the amount of radioactivity remaining in the vial 74a is less than the amount of radioactivity to be administered to the second subject, in the first embodiment, the next subject (second subject) The radiopharmaceutical remaining in the vial 74a is extracted with the extraction needle 26 and contained in the syringe 36. After that, the extraction needle 26 and the air delivery needle 30 move in the + Y direction, that is, rise and are pulled out of the vial 74a.
Next, in the first embodiment, the operator of the administration device 1 removes the vial 74a set in the container arrangement portion 64 together with the shielding container 66a, and instead sets the vial 74b together with the shielding container 66b. However, the first embodiment is not limited to the configuration in which the vials 74a and 74b are manually replaced, and the vials 74a and 74b may be replaced by a jig or an apparatus.

In the control device 8, is the radioactivity amount of the radiopharmaceutical contained in the vial 74b greater than the difference between the radioactivity amount to be administered to the second subject and the radioactivity amount of the radiopharmaceutical contained in the syringe 36? Judge whether or not. When the control device 8 determines that the radioactivity of the radiopharmaceutical contained in the vial 74b is greater than the difference between the dose of the second subject and the radiopharmaceutical contained in the syringe 36. The air delivery needle 30 and the extraction needle 26 descend and are punctured by a stopper (not shown) of the vial 74b, and the amount contained in the syringe 36 of the radioactivity amount of the radiopharmaceutical to be administered to the second subject is determined. The reduced amount is extracted into the syringe 36 and combined with the radiopharmaceutical in the vial 74a previously contained in the syringe 36 in the syringe 36. The extracted radiopharmaceutical is administered to the second subject via syringes 34, 36, tube portions 31b, 31c.

If there is another subject (third subject) after administration, and if some of the radiopharmaceutical remains inside the vial 74b, this radiopharmaceutical can be used for administration by the third subject. You may use it. At this time, after obtaining the residual radioactivity amount in the vial 74b and the third dose, which is the dose of the third subject, the extraction needle in which the radioactive drug remaining inside the vial 74b is in the vial 74b. Extracted into syringe 36 by 26. After that, the extraction needle 26 and the air delivery needle 30 are pulled out of the vial 74b.
The above operation is not limited to the one performed using two vials, and if the amount of residual radioactivity in the vial 74b is less than the amount of radioactivity to be administered to the third subject, the above operation is further three. It can also be done with one or more vials. When the radiopharmaceutical is administered from the three vials, the vial 74b is replaced with another vial together with the shielding container 66b. At this time, the air delivery needle 30 and the extraction needle 26 descend and are punctured by the plug body of another vial, and the amount extracted earlier of the amount of the radioactive drug to be administered to the third subject is used. Extract the reduced amount. The extracted radiopharmaceutical is administered to a third subject via syringes 34, 36, tube portions 31b, 31c.
In the first embodiment, as described above, the extracted radiopharmaceutical 67 was stored in the syringe 36, and the amount of the radiopharmaceutical 67 to be administered to one subject was housed in the syringe 36. The configuration is not limited to the configuration in which the radiopharmaceutical is later administered to the subject, and the configuration may be such that the radiopharmaceutical 67 is administered each time the radiopharmaceutical drug 67 is extracted.

As described above, the administration device 1 of the first embodiment operates so as to send a part of the radioactive drug 67 contained in the vial 74a (first vial) to the tube portions 31b and 31c. After the mode and the first operation mode, the radioactive agent 67 that was not sent from the vial 74a to the tube portions 31b and 31c in the first operation mode and the vial 74b (second vial) different from the vial 74a are housed. It has a motor M (FIG. 5) driven by a second operation mode in which at least a part of the radioactive agent 67 is sent to the tube portions 31b and 31c together.
In the above, the reason why at least a part of the preserved drug is sent to the tube portions 31b and 31c is that the administration device 1 operates so that a part of the preserved drug is discarded via the tube portions 31b and 31c. Also includes.

Further, in the first embodiment, in the above configuration, physiological saline is injected into the syringe 36 by the tube portion 31d connected to the saline bag 3 and administered to the subject together with the radioactive drug 67. May be good. In this way, the radioactive agent 67 adhering to the inner wall of the tube 31 or the syringe 36 can be washed away, and the entire amount of the radioactive agent 67 can be effectively utilized.

In the first embodiment, the syringe drive units 55a and 55c are driven and the flow path switching units 33a, 33c and 33d are automatically switched by a motor or actuator such as a stepping motor (not shown). The driver of the drive unit that drives the syringe drive units 55a and 55c is controlled by a control signal based on the liquid amount calculated from the radioactivity amount of the radioactive agent 67. The amount of radioactivity may be input from the operation unit 6 by a medical worker or the like, or may be detected by the RI detector 65, or calculated from the test information and the known attenuation rate (attenuation curve) of the radiopharmaceutical 67. It may be something to do. The amount of liquid may be calculated by the control device 8 (FIG. 5) housed in the device housing 20 or connected to an external communication connector (not shown), or may be calculated via the operation unit 6. It may be input by a surgeon such as a medical worker. The control device 8 outputs a control signal S (FIG. 5) to the motor M (FIG. 5) or the like according to the calculated or the amount of liquid input by the operator.

The administration device 1 of the first embodiment has a configuration for determining the extraction amount (dose) of the radioactive drug in performing the above operation. This configuration will be described below.
FIG. 5 is a functional block diagram for explaining the control device 8 included in the administration device 1 of the first embodiment. As described above, the control device 8 can be configured as a computer that executes an extraction control program for the radiopharmaceutical that controls the extraction of the radiopharmaceutical.
The control device 8 includes an input unit 81, a calculation unit 82, and a motor drive unit 83. The input unit 81, the calculation unit 82, and the motor drive unit 83 are all composed of a program and known hardware such as a CPU (central processing unit) and a memory for operating such a program.

The input unit 81 is a user interface for the operator to take in the information input in the operation unit 6. The information input by the operator includes, for example, the dose of the radiopharmaceutical to be administered to the subject and the radioactivity of the radiopharmaceutical contained in one vial 74. When the dose is input to the input unit 81, the input unit 81 functions as a dose acquisition unit. Further, when the radioactivity amount of the radiopharmaceutical contained in the vial 74 is input to the input unit 81, the input unit 81 functions as a radioactivity amount acquisition unit.

Further, the input unit 81 is not limited to such a configuration, and information used for determining the dose and information used for determining the radioactivity amount of the radiopharmaceutical in the vial 74 is input. It may be what is done. The information used to determine the dose is, for example, information such as height, weight, sex and age of the subject. The information for obtaining the radioactivity amount of the radiopharmaceutical in the vial 74 is, for example, the test time of the radiopharmaceutical and the radioactivity amount at the test time (hereinafter, both are collectively referred to as test information). Further, the input unit 81 is not limited to the one that accepts the input using the operation unit 6, and may input the information about the subject from the electronic medical record or the like by communication, or the RI detector 65 detects it. The amount of radioactivity generated may be acquired by communication.

When the information about the subject is input, the input unit 81 passes this information to the calculation unit 82. The calculation unit 82 calculates the dose of the radioactive drug based on the height, weight, etc. of the subject. Further, the calculation unit 82 acquires the radiation dose from the preset test information or the signal indicating the radiation dose output from the RI detector 65. In such a case, the calculation unit 82 functions as a dose acquisition unit and a radioactivity amount acquisition unit together with the input unit 81.
In calculating the dose, the calculation unit 82 calculates, for example, a product obtained by multiplying the body weight of the subject by a preset unit radioactivity amount (MBq). Then, for example, based on the test information, the amount of radioactivity at the time when the administration of the radiopharmaceutical 67 is started is calculated. The amount of radioactivity N during use of a radiopharmaceutical having a half-life of T is calculated by the formula _{N = N 0} × (1/2) ^{t / T} _{from, for example, the amount of radioactivity N 0 at} the test time and the elapsed time t. Will be done. The calculation unit 82 compares the radioactivity in the vial 74 with the dose, and determines whether the amount of radioactivity in each vial is excessive or insufficient with respect to the dose.

The dose in the first embodiment may be either a radioactive amount or a liquid amount. However, in the first embodiment, the control signal S for driving the motor M for extracting the dose of the radiopharmaceutical 67 from the vial 74 is generated based on the liquid volume of the radiopharmaceutical 67. That is, the dose represented by the amount of radioactivity is converted into the amount of liquid in order to generate the control signal S.

In addition, the calculation unit 82 determines whether or not an instruction from a medical worker (assuming that the operator is a medical worker in the first embodiment) is required based on the result of the above-mentioned excess / deficiency determination. When the calculation unit 82 determines that the operator's instruction is necessary, the calculation unit 82 outputs data for displaying a message to the operator on the display 165. Such a calculation unit 82 compares the amount of radioactivity with the dose, and determines whether or not an instruction from the medical staff is necessary. The display 165 determines that the determination unit needs an instruction from the medical staff. When this happens, it functions as a display unit that displays a message to the medical staff.

More specifically, the input unit 81 or the input unit 81 and the calculation unit 82 are the first dose, which is the dose of the radiopharmaceutical to be administered to the first subject, and after the first subject. Obtain a second dose, which is the dose of the second subject to be administered. After the administration to the first subject, the calculation unit 82 compares the remaining amount of the radioactive drug remaining in the vial after the administration to the first subject with the second dose. Then, when the remaining amount is less than the second dose, a message as to whether or not to include this remaining amount in the second dose is displayed on the display 165. The display of the display 165 is displayed by the calculation unit 82 outputting the control signal S to control a driver (not shown) of the display 165.

In order to perform the above processing, in the first embodiment, the operator inputs to the input unit 81 the information necessary for calculating the dose and the amount of radioactivity in the vial 74 for the plurality of subjects. At this time, the surgeon also inputs the order and time of administration to the subject. At this time, in the first embodiment, the radiopharmaceuticals contained in the plurality of vials are administered to the plurality of subjects.
The calculation unit 82 determines whether or not the amount of radioactivity in the vial is equal to or greater than the dose for the second subject to be administered after the first subject. The first subject is not limited to the subject who receives the first administration among the plurality of subjects, and may be any subject among the plurality of subjects. The second subject is not limited to the subject who receives the administration immediately after the first subject, but the administration is performed between the first subject and the second subject. There may be a subject to receive.

(Radioactive drug administration method and program)
FIG. 6 is a diagram for explaining the method of administering the radiopharmaceutical of the first embodiment, and is a flowchart for explaining the process of administering the radiopharmaceutical by the control device 8 shown in FIG. The flowchart of FIG. 6 illustrates an example of administering a radiopharmaceutical extracted from two vials 74a, 74b to at least two subjects. Further, in this description, the subject who receives the administration first of the two subjects is also referred to as the "first subject", and the subject who receives the administration later is also referred to as the "later subject". Further, in the explanation of the flowchart of FIG. 6, the amount of radioactivity to be administered to one subject is referred to as “dose”. The dose shall be the total amount of radioactivity administered to one subject in a single dose.

As shown in FIG. 6, the control device 8 first obtains the dose to be administered to the subject (step S101). The acquisition of the radioactive agent 67 may be performed by inputting to the input unit 81 by an operator or a medical worker, or may be calculated by the calculation unit 82.
The process of obtaining the dose by calculation is performed, for example, as follows. At this time, the input unit 81 sequentially accepts the input of information such as the physique, gender, and age of the subject. In addition, the input unit 81 accepts the input of the radiopharmaceutical information such as the test information of the radiopharmaceutical 67 to be administered to the subject. Further, the input unit 81 accepts the input of the administration time at which the administration to the subject is started. The calculation unit 82 calculates the dose required for the test from the physical constitution and the like of the subject.

Next, the control device 8 acquires the amount of radioactivity of the radiopharmaceutical 67 contained in the vial 74a, which is the first vial (step S102). The acquisition of the radioactivity amount is performed, for example, by the calculation unit 82 calculating the radioactivity amount of the radiopharmaceutical 67 at the start time from the test information or the like. Here, the calculation unit 82 calculates the excess or deficiency of the amount of radioactivity with respect to the dose of the radiopharmaceutical 67 contained in the first vial (step S103).
Next, the calculation unit 82 determines whether or not the instruction of the medical staff is necessary based on the result of the calculation performed in step S103 (step S104). If the vial 74a contains a sufficient amount of radiopharmaceutical to be administered to the previous subject, it is determined that no instructions are required for the administration of the previous subject (step S104: No). The motor drive unit 83 outputs a control signal S for extracting the radioactive drug 67 for the dose from the vial 74a to the motor M under the control of the calculation unit 82 (step S110b).

The motor M rotates at a rotation speed according to the control signal S. As the motor M rotates, the air delivery needle 30 and the extraction needle 26 are lowered and punctured by a plug body (not shown) of the vial 74a, and the inside of the vial 74a and the tube portion 31a communicate with each other. Further, the rotation of the motor M drives the plunger portion 37 of the syringe 34 to extract the radioactive drug 67 for the dose calculated in step S104 from the vial 74a.
In addition, such a motor M is used together with an actuator. The motor M may be common to a plurality of mechanisms, or may be provided for each mechanism.
Subsequently, the calculation unit 82 drives the plunger unit 37 with respect to the motor M to administer the extracted radioactive drug to the subject (step S111).

After the administration of the radiopharmaceutical to the previous subject is completed, the administration device 1 obtains the dose of the radiopharmaceutical to be administered to the later subject (step S101). Then, the amount of radioactivity remaining in the vial 74a is acquired (step S102), and the excess or deficiency with respect to the dose of the subject later is calculated (step S103). When the amount of radioactivity satisfies the dose, the calculation unit 82 extracts the radiopharmaceutical agent 67 (step S110b) and administers it to the subsequent subject (step S111) in the same manner as the administration to the previous subject. ..

On the other hand, when the amount of radioactivity remaining in the vial 74a is insufficient in the dose according to the calculation in step S103, the calculation unit 82 determines that the instruction of the medical staff is necessary (step S104: Yes). Then, a message notifying that the amount of radioactivity of the radioactive agent 67 is insufficient is controlled to be displayed on the display screen 165 (step S105). The display 165 displays, for example, a message such as "Insufficient radioactivity, do you administer with radiopharmaceuticals in other vials?"

The healthcare professional confirms the message and administers the radiopharmaceutical to the later subject together with the remaining amount of radioactivity in the vial 74a and the radiopharmaceutical 67 contained in the vial 74b (second operation mode). ) Enter the instruction of whether or not. The calculation unit 82 determines whether or not to continue the administration work from the input unit 81 (step S106). When the radioactive drug 67 contained in the vial 74a is insufficient for the dose of the subsequent subject and the administration operation is not continued (step S106: No), the administration device 1 ends the administration of the radioactive drug 67. ..

Further, when the calculation unit 82 determines that the administration operation is to be continued (step S106: Yes), the calculation unit 82 determines whether or not to replenish with an additional vial (step S107).
Next, when refilling with an additional vial (step S107: Yes), the calculation unit 82 determines whether or not the vial 74a has been replaced with the vial 74b (step S108). The replacement of the vials 74a and 74b may be automatically detected by opening and closing the door of the administration device 1, or the operator may input from the input unit 81 that the replacement has been completed. May be good. The calculation unit 82 waits until the replacement of the vials 74a and 74b is completed (step S108: No).

After the replacement of the vials 74a and 74b (step S108: Yes), the calculation unit 82 acquires the radioactivity amount of the radiopharmaceutical contained in the replaced vial 74b in the same manner as in the vial 74a (step S109). Then, based on the amount of radioactivity, the amount of liquid corresponding to the shortage of the dose of the radiopharmaceutical to be administered to the subject later is calculated, and the calculated amount of radiopharmaceutical 67 is extracted from the vial 74b. The calculation unit 82 controls the motor M so that the radioactive drug 67 extracted from the vial 74a and stored in the syringe 36 and the radioactive drug 67 extracted from the vial 74b are collectively administered by the syringe 36 (step S111). ).

Among the above treatments, in the method for administering the radiopharmaceutical of the first embodiment, step S110b corresponds to the first step of sending a part of the radiopharmaceutical contained in the first vial to the administration flow path. Further, in step S110a, after the first step, at least one of the radioactive agent not sent from the first vial to the administration channel in the first step and the radioactive agent contained in the second vial different from the first vial. It corresponds to the second step of sending the parts together to the administration flow path. Further, in the first embodiment, step S101 corresponds to the step of obtaining the dose of the radiopharmaceutical to be administered to the subject, and step S102 corresponds to the radioactivity amount of the radiopharmaceutical contained in one vial. Corresponds to the acquisition process. Further, steps S103 and S104 correspond to a step of comparing the radioactivity amount and the dose and determining the necessity of instruction from the medical staff. Further, step S105 corresponds to a step of displaying a message to the medical staff when it is determined that an instruction from the medical staff is necessary.

Further, in the flowchart shown in FIG. 6, step S101 is a first dose to be administered to the first subject and a second dose to be administered after the first subject in the step of obtaining the dose. It corresponds to the step of obtaining the second dose, which is the dose of the second subject. Further, in the step of determining the necessity of instructions from the medical staff, steps S103, S104 and S106 are administered to the first subject, then to the first subject, and then into the vial. Compare the remaining amount of the remaining radiopharmaceutical with the second dose, and if the remaining amount is less than the second dose, display a message as to whether or not to include the remaining amount in the second dose. Corresponds to the process. In addition, each step (step) shown in FIG. 6 is performed by a radiopharmaceutical administration program operating on the control device 8. This program is performed in a first operation mode in which a control device 8 configured as a computer is operated to send a part of the radioactive drug contained in the first vial to the administration flow path, and after the first operation mode. In the first operation mode, the radiopharmaceutical that was not sent from the first vial to the administration channel and at least a part of the radiopharmaceutical contained in the second vial different from the first vial are combined and sent to the administration channel. Two operation modes and a drive function driven by are realized.

In addition, the method of administering the radiopharmaceutical of the first embodiment is the method of administering the radiopharmaceutical drug executed by the device for administering the radiopharmaceutical. Then, the step of obtaining the dose of the radiopharmaceutical to be administered to the subject, the step of obtaining the radioactivity amount of the radiopharmaceutical contained in one vial, and the radioactivity amount and the dose are compared. The dose includes a step of determining the necessity of instructions from the medical worker and a step of displaying a message to the medical worker when the judgment unit determines that the instruction from the medical worker is necessary. In the step of obtaining, the first dose administered to the first subject and the second dose which is the dose of the second subject administered after the first subject are obtained. In the process of obtaining and determining the necessity of instructions from medical personnel, the remaining amount of the radiopharmaceutical remaining in the vial after administration to the first subject and after administration to the first subject is determined. If the remaining amount is less than the second dose as compared to the second dose, a message as to whether or not to include the remaining amount in the second dose is displayed.
Of the steps shown in FIG. 6, step S101 corresponds to the step of obtaining the dose of the radiopharmaceutical. Steps S102 and S119 correspond to the step of acquiring the amount of radioactivity. Further, step S106 corresponds to a step of determining the necessity of instruction from the medical staff, and steps S104 and S105 correspond to a step of displaying a message to the medical staff.

The radiopharmaceutical administration program of the first embodiment is a program for causing the control device 8 of the administration device 1 to execute the above-mentioned radiopharmaceutical administration method.

According to the administration device 1 described above, since it is possible to operate in the first operation mode in which a part of the radioactive drug contained in the vial 74a is sent to the administration flow path, the radioactive drug contained in the vial 74a can be operated. Some of them can be administered to the subject. Further, in the administration device 1, after the first operation mode, at least one of the radioactive agent not sent from the vial 74a to the administration flow path in the first operation mode and the radioactive agent contained in the vial 74b different from the vial 74a. It can operate in the second operation mode in which the parts are combined and sent to the administration flow path. Therefore, the administration device 1 can administer a larger amount of the radioactive drug contained in the vial 74a to one subject. In such a first embodiment, even when the amount of radioactivity of the radiopharmaceutical is insufficient due to a delay in the administration timing or the like, a large number of radiopharmaceuticals contained in a plurality of vials are efficiently tested. Can be administered to a person.

Further, the administration device 1 is a second administration which is a first dose to be administered to the first subject and a second dose to be administered after the first subject. You can get the quantity. In addition, the calculation unit 82 compares the remaining amount of the radioactive drug remaining in the vial after the administration to the first subject after the administration to the first subject with the second dose. If the remaining amount is less than the second dose, a message as to whether or not to include the remaining amount in the second dose can be displayed on the display 165. Therefore, in the first embodiment, it is possible to determine whether or not to administer the radiopharmaceutical contained in one vial to a plurality of people at the discretion of the medical staff.

In the flowchart shown in FIG. 6, the dose and the amount of radioactivity are acquired each time the administration is started for one subject. However, the first embodiment is not limited to such a configuration, and the extraction amount of the radiopharmaceutical is calculated in advance for a plurality of subjects to which the radiopharmaceutical is continuously administered, and the administration schedule is established. You may do so.

[Second Embodiment]
Next, a second embodiment of the radiopharmaceutical administration device of the present invention will be described.
FIG. 7 is a schematic view for explaining the radiopharmaceutical administration apparatus of the second embodiment of the present invention. The radiopharmaceutical administration device of the second embodiment includes container arrangement portions 64a and 64b which are holding portions capable of simultaneously holding at least two vials 74a and 74b (first vial and second vial). Here, the "holding portion that can be held at the same time" may be one member that holds a plurality of vials, or may be a plurality of holding portions that can each hold one vial.
The container arranging portions 64a and 64b are housed inside the device housing 20 in the same manner as the container arranging portion 64 shown in FIG. Such a dosing device of the second embodiment opens and closes the shielding door pair 10 less frequently for exchanging the vials 74a and 74b than the dosing device 1 of the first embodiment, and reduces the exposure dose to the operator and the like. can do.

Here, an example will be described in which the radiopharmaceutical 67 contained in the vial 74a is administered to a subject and then the radiopharmaceutical 67 contained in the vial 74b is administered to another subject. In the administration device of the second embodiment, the extraction needle 26 and the syringe 34 extract a dose of the radioactive drug 67 from the vial 74a. The extracted radiopharmaceutical 67 is mixed with physiological saline and administered to the subject as needed. The vial 74a is held in the container arrangement portion 64 even after the end of administration.
Next, when administering to another subject, the extraction needle 26 and the syringe 34 extract the radioactive drug 67 remaining in the vial 74a. If the remaining amount is less than the amount of radiopharmaceutical used for the next administration, the vial 74b is set in the container placement section 64b. Then, the radioactive drug extracted from the vial 74a and the radioactive drug 67 contained in the vial 74b are mixed and administered to the subject.

In order to realize the above operation, the administration device of the second embodiment drives the extraction needle 26 and the air delivery needle 30 in the vertical direction indicated by + Y and −Y, and also drives them in the plane direction indicated by + X and −X. It is preferable to do so. Further, the second embodiment is not limited to such a configuration. For example, the container arrangement portions 64a and 64b are configured to be movable in the plane direction indicated by + X and −X, and the vials 74a and 74b are extracted. The needle 26 and the air delivery needle 30 may be moved to the puncture position. In this way, the pair of extraction needles 26 and the air delivery needle 30 can extract the radioactive agent 67 in order from both the vials 74a and 74b, so that the extraction needles 26 and the air delivery needle 30 correspond to the number of vials. There is no need to provide more than one. Such a configuration suppresses an increase in the number of parts of the administration device, and even if a plurality of vials can be accommodated, it is advantageous for miniaturization of the device.

In the above-described embodiment, an example in which the residual liquid in the first vial is effectively utilized when the amount of radioactivity of the radiopharmaceutical contained in the first vial is larger than the amount of radioactivity to be administered has been described. However, the present invention is not limited to this, and when the amount of radioactivity of the radiopharmaceutical contained in the first vial is less than the amount of radioactivity to be administered, all of the radiopharmaceutical contained in the first vial and the first vial. It may be a combination of at least a part of the radiopharmaceutical contained in a second vial different from the above. In such a modification, for example, in the administration device 1 described in the first embodiment, all of the radiopharmaceutical contained in the vial 74a is temporarily contained in the syringe 36 and then contained in the syringe 36. The syringe drive 55c may be operated so that the radiopharmaceutical and at least a part of the radiopharmaceutical contained in the vial 74b are combined and sent to the administration channel.

The above embodiment includes the following technical ideas.
(1) A first operation mode in which a part of the radioactive drug contained in the first vial is sent to the administration flow path, and after the first operation mode, the first vial in the first operation mode. A second operation mode in which the radiopharmaceutical that was not sent from the administration channel to the administration channel and at least a part of the radiopharmaceutical contained in the second vial different from the first vial are combined and sent to the administration channel. A radiopharmaceutical administration device having a drive unit driven by.
(2) The second operation mode further includes a storage unit for temporarily storing all of the radioactive drug left in the first vial after the first operation mode, and the second operation mode is housed in the storage unit. The radioactive drug administration device according to (1), wherein the radioactive drug in the first vial and a part or all of the radioactive drug contained in a second vial different from the first vial are combined.
(3) A dose acquisition unit that acquires the dose of the radioactivity drug to be administered to the subject, a radioactivity amount acquisition unit that acquires the radioactivity amount of the radioactivity drug contained in one vial, and the radiation. A judgment unit that compares the dose with the dose to determine the necessity of instructions from the medical worker, and when the judgment unit determines that instructions from the medical worker are necessary, a message to the medical worker is sent. The dose acquisition unit has a display unit for displaying, and the dose acquisition unit has a first dose to be administered to the first subject and a second subject to be administered after the first subject. A second dose, which is the dose of the examiner, was obtained, and the determination unit remained in the vial after being administered to the first subject after being administered to the first subject. A message as to whether or not to include the remaining amount in the second dose when the remaining amount of the radiopharmaceutical is compared with the second dose and the remaining amount is less than the second dose. Is displayed on the display unit.
(4) A storage unit that temporarily stores at least a part of the radioactive drug contained in the first vial, a radioactive drug contained in the storage unit, and a second vial different from the first vial. A radiopharmaceutical administration device comprising an operation mode for sending at least a part of the radiopharmaceutical to the administration flow path and a drive unit driven by the vial.
(5) A method for administering a radiopharmaceutical, which is carried out by a radiopharmaceutical administration apparatus, wherein a part of the radiopharmaceutical contained in the first vial is sent to an administration flow path, and the first step is After that, the radioactive drug that was not sent from the first vial to the administration channel in the first step and at least a part of the radioactive drug contained in the second vial different from the first vial are combined and described. A method of administering a radiopharmaceutical, comprising a second step of feeding to the administration channel.
(6) A method for administering a radiopharmaceutical, which is carried out by a radiopharmaceutical administration device, in which a step of obtaining a dose of the radiopharmaceutical to be administered to a subject and a radio wave contained in one vial are obtained. A step of acquiring the radioactivity amount of a drug, a step of comparing the radioactivity amount with the dose, and determining the necessity of an instruction from a medical worker, and a step of determining the necessity of an instruction from a medical worker are required in the determination step. The first dose to be administered to the first subject and the first dose in the step of obtaining the dose, including the step of displaying a message to the medical worker when the determination is made. In the step of obtaining a second dose, which is the dose of the second subject to be administered after the subject, and determining the necessity of instructions from a medical worker, the first subject After administration to the first subject, the remaining amount of the radiopharmaceutical remaining in the vial after being administered to the first subject is compared with the second dose, and the remaining amount is the second dose. A method for administering a radiopharmaceutical, which displays a message as to whether or not the remaining amount is included in the second dose.
(7) A radiopharmaceutical administration program for causing a radiopharmaceutical administration apparatus to execute the radiopharmaceutical administration method of (5) or (6).

1 ... Administration device 3 ... Raw food bag 6 ... Operation unit 8 ... Control device 10 ... Shielding door pair 10a, 10b ... Shielding door 13 ... Tube holding unit 14 ... Switching member holding portions 16a, 16c ... Opening 17 ... Handle 20 ... Device housing 20a ... Main body 21a, 21b ... Needle base 26 ... Extraction needle 29 ... Needle body 30.・ ・ Air delivery needle 31 ・ ・ ・ Tubes 31b, 31c, 31d ・ ・ ・ Tube part 31a,
32 ... Air vented filters 33a, 33c, 33d ... Flow path switching section 34, 36 ... Syringe 37 ... Plunger section 39 ... Syringe body 51 ... Main board mounting base section 55a, 55c ・ ・ ・ Syringe drive part 56 ・ ・ ・ Guide hole 62 ・ ・ ・ Emergency stop switch 64 ・ ・ ・ Container arrangement part 64a, 64b ・ ・ ・ Container arrangement part 65 ・ ・ ・ RI detector 66, 66a, 66b ・・ ・ Shielding container 67 ・ ・ ・ Radioactive agent 68 ・ ・ ・ Syringe shielding cover 73 ・ ・ ・ Drawer unit 74a, 74b, 74c ・ ・ ・ Vial 81 ・ ・ ・ Input unit 82 ・ ・ ・ Calculation unit 83 ・ ・ ・ Motor drive Part 110 ... Detachable cassette 111 ... Main board 121 ... Sub board 164 ... Power switch 165 ... Display 350 ... Suspension stand M ... Motor S ... Control signal

Claims (7)

A first operation mode that operates to send a part of the radioactive drug contained in the first vial to the administration flow path, and after the first operation mode, the administration from the first vial in the first operation mode. It is driven by a second operation mode in which the radioactive drug not delivered to the flow path and at least a part of the radioactive drug contained in the second vial different from the first vial are combined and sent to the administration channel. A radiopharmaceutical administration device having a drive unit. It further has a containment unit for temporarily accommodating all of the radiopharmaceutical left in the first vial after the first mode of operation.
The second operation mode combines the radiopharmaceutical in the first vial contained in the containment unit with some or all of the radiopharmaceutical contained in a second vial different from the first vial. Item 2. The radiopharmaceutical administration device according to item 1. A dose acquisition unit that acquires the dose of the radiopharmaceutical to be administered to the subject,
A radioactivity acquisition unit that acquires the radioactivity of the radiopharmaceutical contained in one vial,
A determination unit that compares the amount of radioactivity with the dose and determines the necessity of instructions from a medical professional.
It has a display unit for displaying a message to the medical staff when the judgment unit determines that an instruction from the medical staff is necessary.
The dose acquisition unit is a second dose, which is a first dose administered to the first subject and a second dose administered after the first subject. Get the dose,
After the administration to the first subject, the determination unit compares the remaining amount of the radioactive drug remaining in the vial after the administration to the first subject with the second dose. A radiopharmaceutical administration device that displays a message on the display unit as to whether or not the remaining amount is included in the second dose when the remaining amount is less than the second dose. A storage unit that temporarily stores at least a part of the radiopharmaceutical contained in the first vial,
An operation mode in which the radioactive drug contained in the container and at least a part of the radioactive drug contained in the second vial different from the first vial are sent to the administration channel together.
A radiopharmaceutical administration device comprising a drive unit driven by. A method of administering a radiopharmaceutical that is performed by a radiopharmaceutical dosing device.
The first step of sending a part of the radioactive drug contained in the first vial to the administration channel, and
After the first step, at least a part of the radiopharmaceutical that was not sent from the first vial to the administration channel in the first step and the radiopharmaceutical contained in the second vial different from the first vial. A method for administering a radiopharmaceutical, which comprises a second step of sending the cells together with the administration channel. A method of administering a radiopharmaceutical that is performed by a radiopharmaceutical dosing device.
The process of obtaining the dose of the radiopharmaceutical to be administered to the subject, and
The process of obtaining the radioactivity amount of the radiopharmaceutical contained in one vial,
A step of comparing the amount of radioactivity and the dose to determine the necessity of instructions from a medical professional, and
Including the step of displaying a message to the medical staff when it is judged that the instruction from the medical staff is necessary in the judgment step.
In the step of obtaining the dose, the first dose to be administered to the first subject and the dose of the second subject to be administered after the first subject. Get a second dose,
In the step of determining the necessity of instructions from the medical staff, the remaining amount of the radioactive drug remaining in the vial after being administered to the first subject after being administered to the first subject is determined. , If the remaining amount is less than the second dose as compared to the second dose, a radiopharmaceutical that displays a message as to whether or not to include the remaining amount in the second dose. Administration method. A radiopharmaceutical administration program for causing a radiopharmaceutical administration apparatus to perform the method for administering a radiopharmaceutical according to claim 5 or 6.

Images