JP2019107446A - Implementation method and apparatus of intravenous drip injection - Google Patents

Abstract

To control a concentration of a prescribed component in a humor to a prescribed concentration or more.SOLUTION: The implementation method of intravenous drip injection includes: a first step of starting to administer a transfusion including a prescribed component by intravenous drip injection to an administration object person; a second step of collecting a humor from the administration object person to whom the transfusion is administered; a third step of measuring a concentration of the prescribed component in the collected humor; and a fourth step of changing the concentration of the prescribed component in the transfusion according to the concentration of the prescribed component in the humor.SELECTED DRAWING: Figure 4

Description

  The present invention relates to a method of performing drip injection and a device for performing drip injection.

  Ascorbic acid (vitamin C) is ingested by the diet, absorbed from the small intestine and distributed widely to organs and tissues in the body. Biochemically, it is involved in the synthesis of collagen, the synthesis of carnitine, the synthesis of adrenocortical hormone, the synthesis of catecholamine, the decomposition of lipid peroxide, the decomposition of active oxygen, etc., and plays an important role in vivo. In recent years, the strong reducing property of vitamin C has attracted attention for its anti-cancer effect, immune function enhancement, skin-beautifying effect and whitening effect, and is applied to high-concentration vitamin C instillation and the like. As documents open to high concentration vitamin C instillation therapy, for example, the following Patent Document 1 and Non-Patent Document 1 can be mentioned.

Patent No. 4124214

"The Riordan IVC Protocol for Adjunctive Cancer Care Intravenous Ascorbate as a Chemotherapeutic and Biological Response Modifying Agent", [online], February 2013, [October 16, 2017 search], Internet <URL: http: // www .doctoryourself.com / RiordanIVC.pdf>

  In high-concentration vitamin C instillation, an infusion containing ascorbic acid is given to the patient by instillation. Then, after completion of the instillation, the concentration of ascorbic acid in the blood collected from the patient is measured, and the concentration of ascorbic acid in the infusion to be administered in the next high concentration vitamin C instillation therapy is determined based on the measurement result.

  Since the concentration of ascorbic acid in the blood is measured after the end of the drip injection, while the drip injection is being performed, it can not be judged whether the concentration of ascorbic acid in the liquid administered to the patient is appropriate. Therefore, it is difficult to control the concentration of ascorbic acid in blood to a predetermined concentration or more. Such a subject is not limited to the high concentration vitamin C instillation therapy, and is a common subject when controlling the concentration in the body fluid of a predetermined component to be administered by instillation to a predetermined concentration or more.

  Therefore, one aspect of the disclosed technology is to control the concentration of a predetermined component in body fluid to a predetermined concentration or more.

  One aspect of the disclosed technology is exemplified by the following method of performing drip injection. The implementation method of the present drip injection comprises a first step of starting administration of an infusion containing a predetermined component by drip injection to a recipient, and second collecting of a body fluid from the recipient to which the infusion is administered. A third step of measuring the concentration of the predetermined component in the collected body fluid, and a fourth step of changing the concentration of the predetermined component in the infusion according to the concentration of the predetermined component in the body fluid And a process. The disclosed technology can also be understood as a device for performing drip injection.

  The disclosed technology can control the concentration of a predetermined component in body fluid to a predetermined concentration or more.

FIG. 1 is a diagram showing an example of the configuration of the infusion system according to the first embodiment. FIG. 2 is a diagram showing an example of the configuration of the replenishment device. FIG. 3 is a view showing an example of a processing block of the drip system according to the first embodiment. FIG. 4 is a diagram showing an example of a processing flow of the infusion system according to the first embodiment. FIG. 5 is a view showing an example of the configuration of the infusion system according to the second embodiment. FIG. 6 is a diagram showing an example of the configuration of the detection device. FIG. 7 is an example of an entire schematic view of the collecting apparatus. FIG. 8 is an example of a plan view of the portion of the circle A in FIG. FIG. 9 is an example of a plan view of the portion of the circle B in FIG. 7. FIG. 10 is a diagram illustrating an example of processing blocks of the detection device according to the second embodiment. FIG. 11 is a diagram showing an example of a processing flow of the drip system according to the second embodiment. FIG. 12A is a first view showing an example of a configuration in which the puncture member is ejected by the cam mechanism. FIG. 12B is a second view showing an example of a configuration in which the puncture member is ejected by the cam mechanism. FIG. 13A is a first diagram showing an example of a configuration in which a stopper member is driven by a solenoid actuator. FIG. 13B is a second view showing an example of a configuration in which the stopper member is driven by the solenoid actuator.

  Hereinafter, embodiments will be described. The configurations of the embodiments shown below are illustrative, and the disclosed technology is not limited to the configurations of the embodiments.

First Embodiment
(How to carry out instillation)
The implementation method of the instillation according to the first embodiment is
A first step of starting administration of an infusion containing a predetermined component by drip injection to a recipient;
A second step of collecting body fluid from said recipient to whom said infusion is being administered;
A third step of measuring the concentration of the predetermined component in the collected body fluid;
And V. a fourth step of changing the concentration of the predetermined component in the transfusion according to the concentration of the predetermined component in the body fluid.

(First step)
In the first step, administration of an infusion containing a predetermined component by instillation to a recipient is started. Instillation is performed, for example, by an instillation device. The infusion device includes an infusion container storing an infusion containing a predetermined component, an injection needle indwelled in the body, and a tube that connects the container and the injection needle and through which the infusion can flow. The fluid stored in the container is administered into the patient's body via a tube and a needle.

(Second step)
In the second step, the body fluid is collected from the recipient to whom the infusion is being administered. For collection of body fluid from the recipient, a collection device is used. The collection device includes, for example, a puncture device, and collects the body fluid by puncturing the body of the recipient with the puncture device. The collection device may be attached to, for example, the fingertip of the recipient, and may puncture the finger of the recipient to collect the body fluid. The body fluid is, for example, the blood of the recipient.

(Third step)
In the third step, the concentration of the predetermined component in the body fluid of the recipient to whom the infusion containing the predetermined component is administered by instillation is measured. The concentration of the predetermined component is measured, for example, by a measurement device connected to a biosensor. The body fluid collected from the recipient to whom the infusion containing the predetermined component is administered by instillation is spotted on the biosensor. When the biosensor on which the body fluid is spotted is connected to the measuring device, the measuring device measures the concentration of a predetermined component in the body fluid. The predetermined component is, for example, ascorbic acid.

(4th step)
In the fourth step, the concentration of the predetermined component in the infusion is changed according to the concentration of the predetermined component in the body fluid measured in the third step. For example, a syringe in which a predetermined component is stored is connected to the drip container. In the fourth step, for example, when the measured concentration is less than the predetermined concentration, the injector injects the predetermined component into the drip container to increase the concentration of the predetermined component in the infusion. The dose per dose of the predetermined component injected into the drip container by the injector may be limited to the predetermined amount. With such a configuration, it is possible to suppress a rapid change in the concentration of the predetermined component in the infusion solution. Also, for example, a calibration curve and measurement in which the difference between the target concentration of the predetermined component in the body fluid of the recipient and the concentration of the predetermined component in the body fluid of the recipient is associated with the amount of the predetermined component to be added to the infusion. The amount of the predetermined component to be added into the infusion may be determined based on the concentration of the predetermined component in the body fluid. With such a configuration, the concentration of the predetermined component in the patient's blood can be rapidly made to the predetermined concentration.

(Injector)
The injector is
A storage unit for storing the predetermined component;
A connection portion that connects the storage portion and a drip container in which the infusion solution is stored so that the predetermined component can flow;
An injection unit for injecting the predetermined component stored in the storage unit into the drip container via the connection unit by reducing the volume of the storage unit according to the concentration of the predetermined component in the body fluid; Have.

  Predetermined components are stored in the storage section. In the storage unit, a chemical solution containing a predetermined component having a concentration higher than the concentration of the predetermined component in the infusion stored in the drip container may be stored. The storage part and the drip container are connected by the connection part so that a predetermined component can flow. The connection part is, for example, a tube. The injection unit reduces the volume of the storage unit to inject the predetermined component stored in the storage unit into the drip container via the connection unit. The reservoir is, for example, a syringe. The injector may include a plunger that slides within the syringe and may be actuated to reduce the volume of the reservoir. Further, the reservoir may be a container formed to have flexibility, and the injection unit may be configured to reduce the volume of the reservoir by pressing the reservoir. By reducing the volume of the reservoir, the stored predetermined component is injected into the drip container through the connection. The amount of the predetermined component to be injected can be controlled, for example, by how much the volume of the reservoir is reduced.

(Control device)
The implementation method of the instillation according to the first embodiment can also be performed by, for example, a control device exemplified by a computer. The control device is, for example, a Central Processing
It is an information processing apparatus provided with CPU and memory. The CPU is also called a microprocessor unit (MPU) or processor. The CPU is not limited to a single processor, and may be a multiprocessor configuration. The memory is exemplified as a storage unit directly accessed by the CPU. The memory includes Random Access Memory (RAM) and Read Only Memory (ROM). The control device can realize the method of performing the drip injection according to the first embodiment by the CPU executing the program stored in the memory. Moreover, the apparatus carrying the control apparatus which implement | achieves the implementation method of the drip injection which concerns on 1st Embodiment can be called implementation apparatus of drip injection.

  The implementation method of the drip injection which concerns on 1st Embodiment mentioned above is further explained in full detail with reference to drawings below. In the following, high concentration vitamin C instillation therapy, i.e., the case where ascorbic acid is administered to a patient by instillation, is described. A patient is an example of a "subject".

  FIG. 1 is a diagram showing an example of the configuration of the infusion system 1 according to the first embodiment. The infusion system 1 includes an infusion device 10, a measurement device 20, a replenishment device 30, and a collection device 40.

  The infusion device 10 includes an infusion container 11, a tube 12 and an injection needle 13. The drip container 11 is a container for storing an infusion. The infusion contains ascorbic acid. The injection needle 13 is indwelled in the patient's vein. The medical tape 14 is attached to the place where the injection needle 13 is indwelled, and the dropout of the injection needle 13 is suppressed. The tube 12 is formed in a hollow shape. The tube 12 connects the bottom of the drip container 11 and the injection needle 13. By being connected by the tube 12, the infusion stored in the drip container 11 is administered into the patient's body via the tube 12 and the injection needle 13. The dripping device 10 is an example of a "dropping unit". The refilling device 30 is connected to the dripping container 11 via a tube 31 formed in a hollow shape. Ascorbic acid is replenished from the replenishing device 30 to the infusion in the drip container 11 through the tube 31. The tube 31 is an example of the “connection portion”.

  The measuring device 20 measures the concentration of ascorbic acid in the blood collected from the patient. For blood collection, for example, a collection device 40 attached to the patient's fingertip is used. The collection device 40 includes a puncture tool, and collects blood by piercing the patient's finger with the puncture tool. The measuring device 20 includes, for example, a biosensor capable of measuring the concentration of ascorbic acid. The measuring device 20 is connected to the replenishment device 30 by an RS-232C cable, and the measuring device 20 transmits the measurement result to the replenishment device 30 via the RS-232C cable. However, the method of transmitting the measurement result is not limited to the method via the RS-232C cable, and may be wireless communication or wired communication. The measuring device 20 is an example of a “measuring unit”. The collection device 40 is an example of the “collection unit”.

  The refilling device 30 stores a drug solution containing ascorbic acid having a higher concentration than the infusion in the dripping container 11, and injects the drug solution into the dripping container 11 according to the concentration measured by the measuring device 20. FIG. 2 is a diagram showing an example of the configuration of the replenishment device 30. As shown in FIG. In FIG. 2, the upper end 36 b 1 side of the plunger 36 b of the injector 36 is up, and the connection port 36 d side of the injector 36 is down. Hereinafter, with reference to FIG. 2, an example of a structure of the replenishment apparatus 30 is demonstrated. The replenishment device 30 is an example of the “change unit”.

  The replenishment device 30 includes a control board 32, a wireless communication module 33a, an RS-232C module 33b, a display 34, a pressing device 35, and an injector 36.

The wireless communication module 33a is a module that communicates with an external device by wireless communication. The RS-232C module 33 b includes a connection terminal to which a communication cable conforming to the RS-232C standard is connected. The connection cable from the measuring device 20 is connected to the connection terminal of the RS-232C module 33 b. The RS-232C module 33b is a module that communicates with an external device via a communication cable according to the RS-232C standard connected to the connection terminal.

  The display 34 displays various information such as the concentration of ascorbic acid in the currently administered infusion, the measurement result received from the measuring device 20, and the elapsed time since the start of the drip injection.

  The control board 32 can communicate with an external device via the wireless communication module 33a and the RS-232C module 33b. The control board 32 has a CPU and a memory. The control board 32 realizes desired processing by the CPU executing a program stored in the memory.

  The injector 36 includes a syringe 36a, a plunger 36b, a gasket 36c, and a connection port 36d. The syringe 36a is formed in a cylindrical shape whose upper end is open. A drug solution 37 containing ascorbic acid having a higher concentration than the transfusion stored in the drip container 11 of the drip device 10 is stored in the syringe 36 a. The bottom of the syringe 36a is provided with a connection port 36d for communicating the inside and the outside of the syringe 36a, and the tube 31 is connected to the connection port 36d. The plunger 36 b is a rod-like member having a gasket 36 c at one end. The plunger 36 b is inserted from the opening at the upper end of the syringe 36 a so that the gasket 36 c side is directed to the drug solution 37. The upper end 36b1 of the plunger 36b contacts the lower surface of the arm 35e of the pressing device 35. The gasket 36c is formed so as not to have a gap with the inner side surface of the syringe 36a. In the injector 36, when the upper end 36b1 of the plunger 36b is pressed toward the connection port 36d, the plunger 36b moves downward along the inner surface of the syringe 36a. The downward movement of the plunger 36b reduces the volume of the syringe 36a. By reducing the volume of the syringe 36 a, the drug solution 37 in the syringe 36 a is injected into the drip container 11 of the drip device 10 via the connection port 36 d and the tube 31. The syringe 36a is an example of a "reservoir". The tube 31 is an example of the “connection portion”. The pressing device 35 and the plunger 36 b are examples of the “injector”.

  The pressing device 35 is a device that presses the upper end portion 36b1 of the plunger 36b of the injector 36 downward. The pressing device 35 includes a stepping motor 35a, a gear 35b, a gear 35c, a screw shaft 35d and an arm 35e. The stepping motor 35 a is a motor which rotates by a predetermined amount at one time in accordance with an instruction from the CPU of the control board 32. The rotation shaft of the stepping motor 35a is provided with a gear 35b that meshes with the gear 35c. From the gear 35c, a rod-like member is formed upward, and a screw shaft 35d having a screw thread on the outer periphery is formed. The arm 35 e is a plate-like member having a screw hole screwed with the screw shaft 35 d, and is arranged to contact the upper end 36 b 1 of the plunger 36 b of the injector 36 from the upper side. In the pressing device 35, the driving force due to the rotation of the stepping motor 35a is transmitted from the gear 35b to the gear 35c. The screw shaft 35d is rotated by the driving force transmitted through the gear 35c. When the screw shaft 35d rotates, the arm 35e screwed with the screw shaft 35d moves downward. The plunger 36b of the injector 36 moves downward by being pressed by the downwardly moving arm 35e. Since the amount of rotation of the stepping motor 35a is a predetermined amount, the amount of downward movement of the plunger 36b is also a predetermined amount. As the plunger 36b of the injector 36 is lowered by a predetermined amount, the volume of the syringe 36a is decreased by a predetermined amount. As the volume of the syringe 36 a decreases by a predetermined amount, a predetermined amount of the drug solution 37 is injected into the drip container 11 via the tube 31. The pressing device 35 and the plunger 36 b are examples of the “injector”.

<Processing block configuration>
Drawing 3 is a figure showing an example of the processing block of dripping system 1 concerning a 1st embodiment. Each processing block illustrated in FIG. 3 is realized by the CPU of the control board 32 executing a program stored in the memory. However, at least a part of the processing block illustrated in FIG. 3 may include a hardware circuit. The processing block of the drip system 1 according to the first embodiment will be described below with reference to FIG.

  The storage unit 103 stores the set concentration of ascorbic acid in the blood of the patient. The set concentration is a value which is a target value of the concentration of ascorbic acid in the blood of the patient in the high concentration vitamin C instillation therapy according to the first embodiment. The storage unit 103 stores, for example, the set concentration in the auxiliary storage device of the control board 32. The set concentration is an example of the “target concentration”.

  The receiving unit 101 receives the measurement result measured by the measuring device 20 via the wireless communication module 33a or the RS-232C module 33b. The receiving unit 101 passes the received measurement result to the control unit 102.

  The control unit 102 receives the measurement result by the measuring device 20 from the receiving unit 101. Based on the set concentration stored in the storage unit 103 and the measurement result received from the receiving unit 101, the control unit 102 determines whether the concentration of ascorbic acid in the blood of the patient has reached the set concentration. If the concentration of ascorbic acid in the blood has not reached the set concentration, the control unit 102 drives the pressing device 35 to inject the drug solution 37 stored in the injector 36 into the drip container 11 of the drip device 10. As described above, since the amount of rotation of the stepping motor 35a is regulated to a predetermined amount, the concentration of ascorbic acid per injection is constant.

  FIG. 4 is a diagram showing an example of a processing flow of the drip system 1 according to the first embodiment. Hereinafter, with reference to FIG. 4, an example of the processing flow of the drip system 1 which concerns on 1st Embodiment is demonstrated.

  In S1, instillation is started. The step S1 is an example of the “first step”. In S2, the control unit 102, for example, outputs a message or an alarm every predetermined time to prompt the measurement of the ascorbic acid concentration in the blood of the patient. The measuring device 20 measures the concentration of ascorbic acid in the blood of the patient. In the human body, it takes about one minute for blood to be pumped from the heart and returned to the heart. Therefore, the control unit 102 may prompt the measurement, for example, at intervals of one minute or more. For example, the control unit 102 may prompt the measurement at a frequency of once every 20 minutes, once every 10 minutes, once every 5 minutes, or once every minute. The measuring device 20 measures the concentration of ascorbic acid in the blood collected from the patient, and transmits the measurement result to the replenishment device 30. The receiving unit 101 receives the measurement result transmitted from the measuring device 20. The process of S2 is an example of the "second process" and the "third process".

  In S3, the control unit 102 determines whether the concentration of ascorbic acid in the patient's blood has reached the set concentration based on the set concentration stored in the storage unit 103 and the measurement result received from the receiving unit 101. Do. If the set concentration has not been reached (No in S3), the process proceeds to S4. If the set concentration has been reached (Yes in S3), the process proceeds to S5.

  In S <b> 4, the control unit 102 drives the pressing device 35 to inject a predetermined amount of the drug solution 37 into the drip container 11 of the drip device 10. As described above, since the drug solution 37 contains higher concentration of ascorbic acid than the transfusion stored in the drip container 11, the concentration of ascorbic acid of the transfusion stored in the drip container 11 can be increased by this injection. Thereafter, the process proceeds to S2. The process of S4 is an example of the "fourth process".

  In S5, since the concentration of ascorbic acid in the patient's blood has reached the set concentration, the drip injection is continued as it is. At S6, when the prescribed amount of infusion is administered to the patient, the instillation is terminated.

  The concentration of ascorbic acid in the patient's blood is considered to be unstable immediately after the start of the drip injection. Therefore, for example, the control unit 102 may execute the processes after S2 after a predetermined time (for example, 30 minutes) has elapsed since the start of the drip injection.

<Effect of First Embodiment>
In the first embodiment, blood is collected from a patient undergoing instillation and the concentration of ascorbic acid in the blood is measured. When the concentration of ascorbic acid in the blood indicated by the measurement result does not reach the set concentration, the control unit 102 increases the concentration of ascorbic acid in the infusion by injecting the drug solution 37 into the drip container 11 of the drip device 10 . Therefore, according to the first embodiment, it is possible to preferably control the concentration of ascorbic acid in the infusion to be administered by the ongoing drip injection. As a result, according to the first embodiment, the concentration of ascorbic acid in the blood of the patient can be controlled to the predetermined concentration or more.

  In the first embodiment, when the drug solution 37 is injected into the drip container 11, a predetermined amount is injected. Therefore, according to the first embodiment, it is possible to suppress a rapid change in the concentration of ascorbic acid in the infusion solution.

Modification of First Embodiment
In the first embodiment, when the measured concentration of ascorbic acid in the blood does not reach the set concentration, a predetermined amount of the drug solution 37 is injected into the drip container 11. However, the amount of the drug solution 37 injected into the drip container 11 is not limited to a predetermined amount. For example, the control unit 102 stores, in the storage unit 103, calibration curve data in which the difference between the concentration of ascorbic acid in blood and the preset concentration is associated with the amount of the drug solution 37 injected into the drip container 11 The amount of the drug solution 37 to be injected into the drip container 11 may be determined with reference to the calibration curve data. With such a configuration, the concentration of ascorbic acid in the patient's blood can be quickly set to the set concentration.

Second Embodiment
In a first embodiment, blood is collected from the patient during the instillation and the concentration of ascorbic acid in the blood is measured. In the second embodiment, a technique for measuring the concentration of ascorbic acid in blood after the end of drip injection is described.

  In high-concentration vitamin C instillation, blood is collected after the end of the drip injection, and the concentration of ascorbic acid in the collected blood is measured. Ascorbic acid is rapidly degraded in blood, so the measurement results vary depending on the timing of blood collection. Such a change in measurement result is not limited to the high concentration vitamin C instillation therapy, and is common to the case where the concentration of the component to be measured in the body fluid fluctuates depending on the elapsed time from the end of the instillation to collection of the body fluid. Thus, in the second embodiment, a technique will be described in which blood is collected from a patient at a fixed timing after the end of drip injection exemplified in the first embodiment to measure the concentration of ascorbic acid in blood.

(How to carry out instillation)
The implementation method of the instillation according to the second embodiment is
The method further includes a fifth step of detecting the end of the drip injection exemplified in the first embodiment,
In the second step, the body fluid is collected from the recipient at a fixed timing after the end of the drip injection is detected.

The implementation method of instillation according to the second embodiment detects the end of instillation in the fifth step. The end of the drip injection is detected by, for example, a detection device that detects the end of the drip injection. There is no limitation in particular in the method a detection apparatus detects completion | finish of drip injection. The detection device may detect, for example, that the infusion does not flow in the tube of the drip device to detect the end of the drip injection. For example, when the tube of the drip device transmits light, the detection device emits light to the tube, and it may be determined whether an infusion is flowing in the tube based on the intensity of the reflected light of the emitted light. . If no fluid is flowing through the tube, the detection device can detect that the drip injection has ended.

  When the end of the drip injection is detected, a body fluid is collected from the recipient in the second step. The collection device collects the body fluid from the recipient at a fixed timing after the end of the drip injection is detected. The body fluid is, for example, blood. The predetermined timing may be immediately after receiving the notification, or may be after a predetermined time has elapsed after receiving the notification.

The puncture tool used in the second step is
A puncturing part capable of injecting in a predetermined direction;
A holding unit for holding a portion to be punctured of the person to be administered so as to be positioned in the predetermined direction from the puncture unit;
A suppression unit that suppresses ejection of the puncture unit;
And a release unit configured to release suppression by the suppression unit a predetermined time after detecting the end of the drip injection and eject the puncture unit toward the punctured site.

(Puncture section)
The puncture unit can eject in a predetermined direction. For example, the tip of the puncture part is formed in a needle shape. The puncturing portion is ejected, for example, with the tip formed in a needle shape being directed in a predetermined direction. Although there is no limitation in particular in the mechanism which ejects a puncture part, For example, a puncture part is inject | emitted by the repulsive force of the elastic force of an elastic body, or a magnet. Also, for example, the puncturing portion may be ejected by a cam mechanism that converts the pressing operation on the ejection button of the puncture device into movement in a predetermined direction.

(Holding part)
The holding unit holds the punctured site of the recipient in such a manner as to be located in a predetermined direction from the puncture unit. By holding the punctured part by the holding unit, the puncture part ejected in the predetermined direction can puncture the punctured part.

(Restraint department)
The deterring unit suppresses the ejection of the puncture unit. The suppression unit suppresses the ejection of the puncturing portion, thereby suppressing the ejection of the puncturing portion other than the timing at which the body fluid is collected.

(Release part)
The release unit releases the suppression by the suppression unit at a fixed timing after detecting the end of the drip injection. The fixed timing may be immediately after detecting the end of the drip injection, or after a predetermined time has elapsed since the end of the drip injection was detected. The method of clocking a fixed timing may be an analog timer or a digital timer. The puncturing part is ejected in a predetermined direction by the restraining part releasing the suppression by the restraining part. As described above, since the punctured part held by the holding unit is in the predetermined direction, the ejected punctured part can puncture the punctured part.

  The release unit includes, for example, a motor that rotates at a constant angular velocity when detecting the end of the drip injection, and a release member provided on the rotation shaft of the motor. When the releasing member moving by rotation of the motor rotating at a constant angular velocity moves the suppressing portion, the suppression by the suppressing portion is released. When the suppression by the suppression unit is released, the puncturing unit punctures the portion to be punctured to collect the body fluid. Since the motor rotates at a constant angular velocity triggered by detection of the end of the drip injection, the time from the end of the drip injection to the collection of the body fluid becomes constant. In other words, the motor rotating at a constant angular velocity can be said to be an example of an analog timer.

  The release unit may release the suppression of the puncture unit by moving the suppression unit by the solenoid actuator. The solenoid actuator starts driving upon detection of the end of the drip injection. The solenoid actuator is driven as soon as it receives the drive start signal, and therefore, even when the solenoid actuator is employed as the release unit, the time from the end of the drip injection to the collection of the body fluid becomes constant. In other words, a solenoid actuator that receives a signal and immediately drives it can be regarded as an example of a digital timer.

  The implementation method of the drip injection which concerns on 2nd Embodiment mentioned above is further explained in full detail with reference to drawings below. FIG. 5 is a view showing an example of the configuration of the drip system 1a according to the second embodiment. The drip system 1a has a detection device 50 added to the configuration of the drip system 1 according to the first embodiment. The tube 12a in the second embodiment is formed of a member that transmits light.

  The detection device 50 is a device that detects the end of the drip injection. FIG. 6 is a diagram showing an example of the configuration of the detection device 50. As shown in FIG. The detection device 50 includes a control board 51, a wireless communication module 52, a light emitting diode (LED) 53a, an LED 53b, a light receiving unit 54a, a light receiving unit 54b, an alarm 55, and holding members 56 and 56.

  The holding members 56, 56 hold the tube 12a so as not to inhibit the flow of the infusion in the tube 12a. The wireless communication module 52 is a module capable of wireless communication. The control board 51 can communicate with the sampling device 40 via the wireless communication module 52. The control board 51 has a CPU and a memory. The control board 51 realizes a desired process by the CPU executing a program stored in the memory.

  On the control board 51, an LED 53a, an LED 53b, a light receiving unit 54a, a light receiving unit 54b, and an alarm 55 are provided. Hereinafter, when the LED 53a and the LED 53b are not distinguished from one another, they are referred to as the LED 53, and when the light receiving part 54a and the light receiving part 54b are not distinguished from one another, the light receiving part 54 is referred to. The LED 53 and the light receiving unit 54 are disposed along the tube 12 a, and the pair of the LED 53 a and the light receiving unit 54 a is disposed on the upstream side of the tube 12 a than the pair of the LED 53 b and the light receiving unit 54 b. Here, the upstream side of the tube 12a is the side to which the drip container 11 is connected, and the downstream side of the tube 12a is the side to which the injection needle 13 is connected.

  The LEDs 53 are arranged such that the optical axis of the emitted light is directed to the tube 12a. The light receiving unit 54 is disposed such that the light receiving surface faces the tube 12 a. When the LED 53 emits light, at least a part of the emitted light is reflected by the tube 12a. The light receiving unit 54a is provided at a position for receiving the reflected light of the light emitted by the LED 53a, and the light receiving unit 54b is provided at a position for receiving the reflected light of the light emitted by the LED 53b. The intensity of the reflected light reflected by the tube 12a differs between when the infusion is flowing and when it is not flowing within the tube 12a. Therefore, based on the intensity of the reflected light received by the light receiving unit 54, the CPU of the control board 51 can determine whether or not the infusion is flowing in the tube 12a.

  In the determination, for example, the intensity range of the intensity of the reflected light when the infusion is flowing in the tube 12a is stored in advance in the memory. Then, when the intensity of the reflected light received by the light receiving unit 54 is out of the stored intensity range, the CPU of the control board 51 may determine that the infusion does not flow in the tube 12 a. Further, for example, the intensity range of the intensity of the reflected light when the infusion does not flow in the tube 12a is stored in advance in the memory. Then, when the intensity of the reflected light received by the light receiving unit 54 is within the stored intensity range, the CPU of the control board 51 may determine that the infusion does not flow in the tube 12 a.

  The CPU of the control board 51 determines that the drip injection has ended when it is determined that the infusion does not flow in the tube 12a. The CPU of the control board 51 instructs the collection device 40 to start collection of blood via the wireless communication module 52 at a fixed timing after detecting the end of the drip injection. Furthermore, when detecting the end of the drip injection, the CPU of the control board 51 outputs an alarm sound from the alarm 55 to notify the end of the drip injection to the surroundings.

  As described above, the collection device 40 collects blood by puncturing the fingertip of the patient with a puncture tool. 7 to 9 are diagrams showing an example of the configuration of the collecting device 40. FIG. FIG. 7 is an example of an entire schematic view of the collecting device 40. As shown in FIG. FIG. 8 is an example of a plan view of the portion of the circle A in FIG. FIG. 9 is an example of a plan view of the portion of the circle B in FIG. 7. Hereinafter, with reference to FIGS. 7-9, an example of a structure of the extraction apparatus 40 is demonstrated.

  The collecting device 40 includes a clip holding member 41, a motor control unit 42, a stepping motor 43, a stopper release member 44, a stopper member 45, a compression coil spring 46, a base 46a, a puncturing member 47, and a storage cylinder 48.

  The clip holding member 41 includes a first holding member 41a, a second holding member 41b, and a torsion coil spring 41c. Further, as can be understood with reference to FIG. 8, one end of the second holding member 41 b is formed with a concave portion 41 b 1 formed in a U shape in a plan view. The second holding member 41 b can hold the receiving cylinder 48 by sandwiching the receiving cylinder 48 in the recess 41 b 1. In the clip holding member 41, a force is applied in the closing direction of the first holding member 41a and the second holding member 41b by the elastic force of the torsion coil spring 41c. The clip holding member 41 presses the finger F1 sandwiched between the first holding member 41a and the second holding member 41b against the opening 48a of the storage cylinder 48 held in the recess 41b1 by the elastic force of the torsion coil spring 41c. Can be held in the The clip holding member 41 is an example of the “holding portion”. The finger F1 is an example of the “target puncture site”.

  The storage cylinder 48 is a member formed in a tubular shape. A base 46 a is provided at the bottom of the storage cylinder 48. A puncturing member 47 and a compression coil spring 46 are provided inside the storage cylinder 48. One end of the compression coil spring 46 is fixed to the top surface of the base 46 a, and the other end is fixed to the bottom surface of the puncture member 47. An opening 48 a is provided above the storage cylinder 48. The puncturing member 47 is a member whose tip is formed in a needle shape, and is a member that performs blood collection by puncturing the finger F1 with a needle. The puncture member 47 is provided on the compression coil spring 46. The stopper member 45 holds the puncture member 47 from above while restricting the upward movement of the puncture member 47 in a state where the upper end 45 a compresses the compression coil spring 46, and the lower end 45 b can contact the stopper release member 44. Reaching That is, the stopper member 45 presses the puncture member 47 urged by the compression coil spring 46 from the upper side, and suppresses the ejection of the puncture member 47. The stopper member 45 is an example of a "restraint portion".

  When instructed by the detection device 50 to start blood collection, the motor control unit 42 drives the stepping motor 43. The stepping motor 43 is a motor that rotates at a constant angular velocity, for example, every 1⁄4 rotation according to an instruction from the motor control unit 42. A stopper release member 44 is provided on the rotation shaft of the stepping motor 43.

As illustrated in FIG. 9, the stopper releasing member 44 is rotated by the rotation of the stepping motor 43, and the lower end 45b of the stopper member 45 is pushed by the rotating stopper releasing member 44. When the lower end 45 b of the stopper member 45 is pushed by the stopper releasing member 44, the upper end 45 a is detached from the puncturing member 47, whereby the restriction of the ejection of the puncturing member 47 by the stopper 45 is released. When the restriction is released, the puncturing member 47 is ejected along the inner side surface of the receiving cylinder 48 by the elastic force of the compression coil spring 46. The puncturing member 47 that has been ejected punctures the finger F1 through the opening 48a of the storage cylinder 48, whereby blood is collected.

  The movement range of the puncturing member 47 to be ejected is limited to a range in which the puncturing member 47 can puncturing the finger F1 and the pain felt by the patient who has punctured the finger F1 is reduced. Regulation of the movement range of the puncturing member 47 may be realized by adjusting the length of the compression coil spring 46, or a restriction member for restricting the movement range of the puncturing member 47 is attached to the upper surface of the storage cylinder 48 It is also good.

  Since the stepping motor 43 rotates at a constant angular velocity, the time from when the detection device 50 instructs the start of blood collection until the blood collection becomes constant. The collection device 40 is an example of the “collection unit”. The motor control unit 42, the stepping motor 43, and the stopper release member 44 are examples of a "release unit". The concentration of ascorbic acid in the blood collected by the collection device 40 is measured by, for example, a measurement device 20 using a biosensor.

<Processing block configuration>
FIG. 10 is a diagram showing an example of processing blocks of the detection device 50 according to the second embodiment. Each processing block illustrated in FIG. 10 is realized by the CPU of the control board 51 executing a program stored in the memory. However, at least a part of the processing block illustrated in FIG. 10 may include a hardware circuit. Hereinafter, processing blocks of the detection device 50 will be described with reference to FIG.

  The storage unit 503 stores, for example, information indicating an intensity range of the intensity of reflected light when an infusion is flowing in the tube 12a. The information stored in the storage unit 503 may be determined in advance by experiment or the like, for example.

  When notified by the detection unit 502 that the drip injection has ended, the control unit 501 causes the collection device 40 to start collecting the patient's blood and causes the alarm 55 to output an alarm sound.

  The detection unit 502 detects the end of the drip injection. The detection unit 502 controls, for example, the LED 53 and the light receiving unit 54. The detection unit 502 causes the LED 53 to emit light at a predetermined cycle. The detecting unit 502 detects the intensity of the reflected light from the tube 12 a received by the light receiving unit 54. The detection unit 502 detects that the drip injection has ended based on the detected intensity of the reflected light and the information stored in the storage unit 503. Here, in the detection unit 502, the drip injection has ended based on the information that the intensity of the reflected light received by the light receiving unit 54a and the intensity of the reflected light received by the light receiving unit 54b are both stored in the storage unit 503. Detects that the drip injection has ended. When detecting that the drip injection has ended, the detection unit 502 notifies the control unit 501 to that effect. The detection unit 502 is an example of a “detection unit”.

  FIG. 11 is a diagram showing an example of the processing flow of the infusion system 1a according to the second embodiment. Hereinafter, with reference to FIG. 11, an example of the processing flow of the drip system 1a which concerns on 2nd Embodiment is demonstrated.

  In S11, the drip injection is started. When the drip injection is started, as shown in FIG. 7, the clip holding member 41 of the collecting device 40 clamps the patient's finger F1 in a state of being pressed against the opening 48a of the containing cylinder 48. The process of S11 is an example of the “first step”.

In S12, it is determined whether or not the instillation has ended. The detection unit 502 causes the LED 53 to emit light, and detects the intensity of the reflected light from the tube 12 a received by the light reception unit 54. The detection unit 502 determines whether the drip injection has ended based on the detected intensity of the reflected light and the information stored in the storage unit 503. If the drip injection has ended (YES in S12), the process proceeds to S13. If the drip injection has not ended (NO in S12), the detection unit 502 returns the process to S12 after a predetermined time has elapsed. The process of S12 is an example of the “fifth step”.

  In S13, the control unit 501 receives the notification of the end of infusion from the detection unit 502. In S14, the control unit 501 notified of the end of the infusion causes the collection device 40 to start blood collection. As described above, the collection device 40 punctures the patient's finger F1 with the puncture member 47 at a fixed timing from the detection of the end of the drip. At S15, blood is collected from the finger F1 of the punctured patient. The processes of S14 to S15 are an example of the “second step”. In S16, for example, the concentration of ascorbic acid in the blood is measured by the measuring device 20 using a biosensor. The process of S16 is an example of the "third step". The measuring device 20 is an example of a “measuring unit”.

<Effect of Second Embodiment>
In the second embodiment, the control unit 501 notified of the end of the drip injection from the detection unit 502 instructs the collection device 40 to start blood collection at a fixed timing after receiving the notification. The sampling device 40 instructed from the control unit 501 releases the restriction by the stopper member 45 by the stopper releasing member 44 provided on the rotation shaft of the stepping motor 43 rotating at a constant rotation speed. Blood collection is performed when the puncturing member 47 whose restriction is released punctures the finger F1. As a result, the time from the notification of the end of the drip injection to the instruction to start blood collection is constant, and the time from the instruction to start blood collection to the actual blood collection is also constant. Therefore, according to the second embodiment, the time from the end of infusion to blood collection can be made constant.

  In the second embodiment, both the intensity of the reflected light detected by the light receiving unit 54a and the intensity of the reflected light detected by the light receiving unit 54b indicate that the drip injection has ended based on the information stored in the storage unit 503. And detect that the drip injection has ended. In the second embodiment, by double confirmation of the end of the drip injection by the two light receiving parts 54, the possibility of erroneous detection as the end of the drip injection being finished even though the injection is not finished is suppressed. Be done.

Modification of Second Embodiment
In the second embodiment, the light receiving unit 54 measures the intensity of the light reflected by the tube 12a to detect the end of the drip injection. However, the method of detecting the end of the drip injection is not limited to this. For example, the light receiving unit 54 and the LED 53 are disposed facing each other with the tube 12 a inserted, and the light receiving unit 54 receives the transmitted light transmitted through the tube 12 a of the light emitted from the LED 53. The detection unit 502 may detect the intensity of the transmitted light received by the light receiving unit 54, and detect the end of the drip injection based on the detected intensity of the transmitted light.

  In the second embodiment, the puncture member 47 is ejected by the elastic force of the compression coil spring 46. However, the means for ejecting the puncturing member 47 is not limited to the compression coil spring 46. The means for injecting the puncturing member 47 may be ejected, for example, by an elastic force of an elastic body such as a leaf spring or rubber. Further, in the puncture member 47, for example, the puncture member 47 and the base 46a are magnetized and the same poles (for example, the S pole and the S pole) face each other, and the puncture member 47 is ejected by the repulsive force of the magnet. May be

The puncture member 47 may be ejected by a cam mechanism instead of, for example, an elastic force or a repulsive force. 12A and 12B illustrate an example of a configuration in which the puncture member 47 is ejected by the cam mechanism 146. FIG. The cam mechanism 146 includes a cam 146a and a follower 146b. The puncturing member 47 is provided at the upper end of the follower 146b, and the lower end is in contact with the cam 146a. The cam 146a and the button 149 are disposed in contact with each other. When the button 149 is pressed in the state of FIG. 12A, the frictional force with the button 149 rotates the cam 146a. As illustrated in FIG. 12B, the penetrating member 47 can be ejected upward by moving the follower 146b upward by the rotating cam 146a.

  In the second embodiment, the detection device 50 is instructed to start blood collection by releasing the restriction by the stopper member 45 by the stopper release member 44 provided on the rotation shaft of the stepping motor 43 rotating at a constant rotation speed. The time from blood to blood was constant. However, the mechanism which makes the time to blood collection constant after being instructed to start blood collection from detection device 50 is not limited to such a mechanism. For example, the stopper member may be driven by a solenoid actuator.

  13A and 13B illustrate an example of a configuration in which the stopper member 145 is driven by the solenoid actuator 43a. Until the start of blood collection is instructed from detection device 50, as illustrated in FIG. 13A, stopper member 145 holds puncturing member 47 from above to restrict the upward movement of puncturing member 47. . When instructed to start blood collection from the detection device 50, the solenoid actuator 43a moves the stopper member 145 in the direction for releasing the restriction as illustrated in FIG. 13B. Since the solenoid actuator 43a operates immediately upon receiving a blood collection instruction from the detection device 50, the mechanism as illustrated in FIGS. 13A and 13B also instructs the start of blood collection from the detection device 50 to the blood collection. The time can be fixed. When the puncture member 47 is ejected by the cam mechanism 146 as illustrated in FIGS. 12A and 12B, the puncture member 47 may be ejected upward by rotating the cam 146a by the solenoid actuator 43a.

  The embodiments and modifications disclosed above can be combined with each other. For example, by combining the first embodiment and the second embodiment, blood collection in S2 of FIG. 4 may be performed at a fixed timing. For example, blood collection may be performed during dripping by driving the collection device 40 at a predetermined timing after the elapse of a predetermined time and causing the finger F1 to puncture the collection device 40 each time the control unit 501 elapses a predetermined time. The fixed timing may be immediately after the predetermined time has elapsed, or may be after the predetermined time has elapsed since the predetermined time has elapsed. By executing such processing as described above, the control unit 501 can make the blood collection interval constant during the instillation more accurately than in the first embodiment. As a result, the fluctuation of the measurement result of ascorbic acid which is rapidly degraded in blood is suppressed.

<< computer readable recording medium >>
An information processing program that causes a computer or other machine or device (hereinafter referred to as a computer or the like) to realize any of the functions described above can be recorded on a recording medium readable by the computer or the like. Then, the function can be provided by causing a computer or the like to read and execute the program of the recording medium.

Here, a recording medium readable by a computer etc. is a recording medium which can store information such as data and programs electrically, magnetically, optically, mechanically or chemically and read from a computer etc. Say Among such recording media, those removable from a computer etc. are, for example, flexible disks, magneto-optical disks, Compact Disc Read Only Memory (CD-ROM), Compact Disc-Recordable (CD-R), Compact Disc-ReWriterable (CD-RW), Digital Versatile Disc (DVD), Blu-ray Disc (BD), Digital Audio Tape (DAT), 8 mm tape, memory cards such as flash memory, and the like. Further, as a recording medium fixed to a computer or the like, there is a hard disk, a ROM or the like.

1, 1a ... infusion system 10 ... drip 11 ... drip chamber 12, 12a, 31 ... tube 13 ... needles 14 ... medical tape 20 ... measurement device 30, · · Refilling device 32, 51 · · · Control board 33a, 52 · · · wireless communication module 33b · · · RS-232C module 34 · · · display 35 · · · pressing device 35a, 43 · · · stepping motor 35b, 35c: gear 35d: screw shaft 35e: arm portion 36: injector 36a: syringe 36b: plunger 36b1, 45a: upper end portion 36c: gasket 36d · · · · Connection port 37 · · · chemical solution 40 · · · sampling device 41 · · · clip holding member 41a · · · first holding member 41b · · · second holding member 41b1 · · · Recess 41c: Torsion coil spring 42: Motor control unit 43a: Solenoid actuator 44: Stopper release member 45, 145: Stopper member 45b: Lower end portion 46: Compression coil spring 46a,. · Base 47 · · · puncture member 48 · · · storage cylinder 48a · · · opening portion 50 · · · detection device 53, 53a, 53b · · · · LED
54, 54a, 54b ... light receiving unit 55 ... alarm 56 ... holding member 101 ... receiving unit 102, 501 ... control unit 103, 503 ... storage unit 502 ... detection unit 146 ... Cam mechanism 146a ... cam 146b ... follower 149 ... button

Claims (18)

The method of carrying out the instillation
A first step of starting administration of an infusion containing a predetermined component by drip injection to a recipient;
A second step of collecting body fluid from said recipient to whom said infusion is being administered;
A third step of measuring the concentration of the predetermined component in the collected body fluid;
And V. changing the concentration of the predetermined component in the infusion according to the concentration of the predetermined component in the body fluid.
How to carry out instillation. In the fourth step, a predetermined amount of the predetermined component is added to the infusion solution,
The implementation method of the drip injection of Claim 1. In the drip injection, a target concentration of the predetermined component in the body fluid of the recipient is determined;
In the fourth step, a calibration curve correlating the difference between the concentration of the predetermined component in the body fluid of the person to be administered and the target concentration with the amount of the predetermined component to be added to the infusion and the measured body fluid Adding the predetermined component in an amount determined based on the concentration of the predetermined component in the infusion solution,
The implementation method of the drip injection of Claim 1. In the fourth step, the change of the concentration of the predetermined component is
A storage unit for storing the predetermined component;
A connection portion that connects the storage portion and a drip container in which the infusion solution is stored so that the predetermined component can flow;
An injection unit for injecting the predetermined component stored in the storage unit into the drip container via the connection unit by reducing the volume of the storage unit according to the concentration of the predetermined component in the body fluid; Done by having an injector,
The implementation method of the drip injection as described in any one of Claim 1 to 3. The method further includes a fifth step of detecting the end of the drip injection,
In the second step, the body fluid is collected from the recipient at a fixed timing after the end of the drip injection is detected.
The implementation method of the drip injection as described in any one of Claim 1 to 4. In the second step, after the end of the drip injection is detected, the body of the recipient is punctured with a puncture tool at a certain timing to collect the body fluid.
The implementation method of the drip injection according to claim 5. The puncture tool in the second step is
A puncturing part capable of injecting in a predetermined direction;
A holding unit for holding a portion to be punctured of the person to be administered so as to be positioned in the predetermined direction from the puncture unit;
A suppression unit that suppresses ejection of the puncture unit;
And a release unit configured to release suppression by the suppression unit a predetermined time after detection of the end of the drip injection and eject the puncture unit toward the punctured site.
The implementation method of the drip injection of Claim 6. The predetermined component is ascorbic acid,
The implementation method of the drip injection as described in any one of Claims 1-7. The body fluid is blood of the recipient.
A method of performing infusion according to any one of the preceding claims. It is an implementation device for instillation, and
An infusion section for administering an infusion containing a predetermined component by instillation to the recipient;
A collecting unit for collecting body fluid from the subject to whom the fluid is being administered;
A measurement unit that measures the concentration of the predetermined component in the collected body fluid;
And a change unit that changes the concentration of the predetermined component in the infusion according to the concentration of the predetermined component in the body fluid.
Implementing device for drip injection. The changing unit adds a predetermined amount of the predetermined component to the infusion solution.
11. Apparatus for performing infusion according to claim 10. In the drip injection, a target concentration of the predetermined component in the body fluid of the recipient is determined;
The changing unit is a calibration curve in which the difference between the concentration of the predetermined component in the body fluid of the recipient and the target concentration is associated with the amount of the predetermined component to be added to the infusion, and in the measured body fluid Adding an amount of the predetermined component determined based on the concentration of the predetermined component into the infusion solution,
11. Apparatus for performing infusion according to claim 10. The change unit is
A storage unit for storing the predetermined component;
A connection portion that connects the storage portion and a drip container in which the infusion solution is stored so that the predetermined component can flow;
And an injection unit for injecting the predetermined component stored in the storage unit into the drip container via the connection unit by reducing the volume of the storage unit according to the concentration of the predetermined component in the body fluid. ,
13. Apparatus for performing infusion according to any of claims 10-12. It further comprises a detection unit that detects the end of the drip injection for administering the predetermined component to the recipient,
The collection unit collects the body fluid from the recipient at a fixed timing after detecting the end of the drip injection.
14. Device for performing infusion according to any of the claims 10-13. The collection unit puncturing the body of the person to be administered with a puncture tool at a certain timing after detecting the end of the drip injection, and collecting the body fluid.
15. Apparatus for performing infusion according to claim 14. The puncture device is
A puncturing part capable of injecting in a predetermined direction;
A holding unit for holding a portion to be punctured of the person to be administered so as to be positioned in the predetermined direction from the puncture unit;
A suppression unit that suppresses ejection of the puncture unit;
And a release unit configured to release suppression by the suppression unit a predetermined time after detection of the end of the drip injection and eject the puncture unit toward the punctured site.
Apparatus for performing infusion according to claim 15. The body fluid is blood of the recipient.
17. Apparatus for performing infusion according to any one of claims 10 to 16. The predetermined component is ascorbic acid,
18. Apparatus for performing infusion according to any of claims 10-17.

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