JP2019060655A - Measurement system, measurement method and measuring device - Google Patents

Abstract

To provide a measurement system, a measurement method and a measuring device with which it is possible to efficiently execute measurement work regarding reinspection of HbA1c by coordinating a plurality of measuring devices and easily and reliably execute the determination of reinspection of HbA1c.SOLUTION: The measurement system includes: conveyance means for conveying a specimen container; storage means in which the past measurement results of HbA1c of each individual patient are stored; first HbA1c measurement means for measuring the HbA1c of a biological specimen; comparison means for comparing the HbA1c measurement result of a patient by the first HbA1c measuring means with the previous measurement result of the patient; instruction means for instructing that reinspection of HbA1c of the biological specimen be made after conveying the specimen container to a second HbA1c measuring device when the comparison result deviates by a prescribed threshold or more; and second HbA1c measurement means for measuring the HbA1c of biological specimen of the patient with the second HbA1c measuring device on the basis of the instruction.SELECTED DRAWING: Figure 3

Description

  The present invention relates to a measurement system, a measurement method, and a measurement apparatus for measuring a biological component.

Hemoglobins, in particular hemoglobin A1c (hereinafter referred to as “HbA1c”), which is a glycated protein in which hemoglobin is bound to glucose, reflect the average blood glucose level in the past one to two months, so diabetes and metabolic syndrome Are widely used for examination of lifestyle-related diseases including blood glucose control.
In the field of clinical examination, blood glucose level (glucose) and HbA1c are mentioned as a measurement item of a diabetic patient, and measurement of the above-mentioned item is performed as a pre-diagnosis examination.
In order to improve the efficiency of testing work, there are cases where two measuring devices capable of measuring the concentration of HbA1c in blood and a measuring device capable of measuring the concentration of glucose in blood are used in combination via a connecting member. (See, for example, Patent Document 1 and FIG. 4).

JP, 2012-233924, A

Glucose is easy to measure by alternative automatic analyzer etc., but since HbA1c measuring device (HPLC method) requires a dedicated measuring device, a backup machine is installed in case of failure or malfunction of HbA1c measuring device. Often
Here, in the field of the clinical examination, if the measurement result of the predetermined measurement item of the biological sample largely deviates from the previous measurement result of the same patient, the measurement device is replaced with another measurement device and reexamination is performed. There is.
In re-examination of HbA1c, it is conceivable to use the above-mentioned backup machine in combination to improve the efficiency of the examination work, and combining two or more measuring devices including the backup machine to perform more efficient measurement work Is desired.
The present invention makes it possible to execute measurement work more efficiently by taking coordination among a plurality of measuring devices with regard to re-examination of HbA1c, and to execute determination of re-examination of HbA1 c simply and reliably. It is an object of the present invention to provide a measurement system, a measurement method and a measurement apparatus capable of

  A measurement system according to the present invention measures a first HbA1c measuring device and a second HbA1c measuring device for measuring HbA1c of a biological sample stored in a sample container, and glucose of the biological sample stored in the sample container. A measurement system capable of measuring HbA1c of the biological sample by the second HbA1c measurement device after measuring HbA1c of the biological sample by the first HbA1c measurement device; Transport means for transporting the sample container among the HbA1c measuring device of 1, the second HbA1c measuring device and the glucose measuring device, and storage means for storing the measurement results of the past HbA1c of each patient, First HbA1c measuring means for measuring HbA1c of the biological sample by the first HbA1c measuring device; Comparison means for comparing the measurement result of HbA1c in the first HbA1c measurement means of a certain patient with the previous measurement result of the patient stored in the storage means, and the comparison result in the comparison means is greater than a predetermined threshold In the case of separation, the instruction means causes the second HbA1c measurement device to convey the sample container using the conveyance means, and instructs reexamination of the HbA1c of the biological sample by the second HbA1c measurement device; And second HbA1c measurement means for measuring the HbA1c of the biological sample of the patient with the second HbA1c measurement device based on the instruction of the instruction means.

  In the present invention, when the measurement result of HbA1c in the first HbA1c measurement device deviates by a predetermined threshold or more as compared with the previous measurement result of the same patient, the carrier means measures the biological sample of the patient The second HbA1c measuring device is conveyed to the second HbA1c measuring device, and the second HbA1c measuring device instructs re-inspection of the HbA1c. Then, on the basis of the instruction, the second HbA1c measurement device executes a re-examination of HbA1c.

  For example, in the present invention, when the HbA1c measurement apparatus is operated individually and the present invention is compared with the one determined by the person in charge of inspection or the like each time based on the measurement result, the doctor or the person in charge of the inspection It becomes possible to link two HbA1c measurement devices without having to go through the determination of each time, etc., and it becomes possible to process a large number of HbA1c re-examinations in a short time uniformly.

  That is, according to the present invention, when the predetermined threshold value or more is deviated, the biological sample of the patient is transported to the second HbA1c measuring device and reexamined using the transport means. Since a doctor or a person in charge of inspection need not judge the measurement result each time, it becomes possible to uniformly process in a large amount with high accuracy, without being affected by an artificial judgment error or the like.

  As described above, based on the comparison results of the measurement results, HbA1c measurement work can be efficiently performed by making it possible to execute transport, re-examination instructions, and execution of a biological sample of the same patient as a series of processes. It is possible to easily and reliably execute the determination of the re-examination of HbA1c.

  Further, communication means capable of transmitting and receiving measurement result data between the first HbA1c measuring device and the second HbA1c measuring device is provided, and the storage means, the comparison means and the indication means The present invention may be provided in any one of the HbA1c measuring device and the second HbA1c measuring device.

  In this case, either the first HbA1c measuring device or the second HbA1c measuring device is provided with the storage means, the comparison means, and the instruction means, so that the measurement results can be transmitted and received between the two. A plurality of measuring devices can be operated and managed as one system without separately providing a host computer to manage.

  The host computer to which the first HbA1c measuring device and the second HbA1c measuring device are connected, and data of the measurement result from the first HbA1c measuring device and the second HbA1c measuring device to the host computer May be transmitted, and the storage means, the comparison means, and the instruction means may be provided in the host computer.

  In this case, the measurement result is transmitted from the measurement device, and the host computer having the storage means, the comparison means and the indication means is provided, and the host computer stores the measurement results of these measurement devices together. It becomes possible to manage.

Next, it is also possible to grasp the present invention from the aspect of the measurement method.
A measuring method according to the present invention comprises: measuring a first HbA1c measuring device and a second HbA1c measuring device for measuring HbA1c of a biological sample stored in a sample container; and measuring glucose of the biological sample stored in the sample container Measuring the HbA1c of the biological sample with the first HbA1c measuring device and then measuring the HbA1c of the biological sample with the second HbA1c measuring device, The first HbA1c measurement step of measuring the HbA1c of the biological sample of a patient by the HbA1c measurement device of 1, and the comparison step of comparing the measurement result in the first HbA1c measurement step with the previous measurement result of the patient And when the comparison result in the comparison step deviates by a predetermined threshold or more, the transport for transporting the sample container Instructing the second HbA1c measurement device to convey the sample container using the second step and instructing the second HbA1c measurement device to reexamine the biological sample of the patient; and based on the instruction. And B. a second HbA1c measurement step of measuring HbA1c of the biological sample in the second HbA1c measurement apparatus.

  As described above, the first HbA1c measuring step of measuring the HbA1c of the biological sample of a certain patient also by the measuring method including the first HbA1c measuring device and the second HbA1c measuring device and the glucose measuring device, and And a comparison step of comparing the measurement result in the HbA1c measurement step with the previous measurement result of the patient, and when the comparison result deviates by a predetermined threshold value or more, the second HbA1c measurement device Including an instruction step of transporting the container and instructing reexamination by the second HbA1c measurement device, and a second HbA1c measurement step of measuring the biological sample of the patient by the second HbA1c measurement device based on the instruction Thus, as in the case of the measurement system described above, the measurement operation of HbA1c can be performed efficiently, and the determination of the re-examination of HbA1c can be carried out simply and reliably. It is possible to become.

  Moreover, the technical idea disclosed about the said measuring system is applicable also to the measuring method which concerns on this invention similarly.

It is then possible to capture the invention from the side of the measuring device.
A measuring apparatus according to the present invention measures first HbA1c measuring means and second HbA1c measuring means for measuring HbA1c of a biological sample contained in a sample container, and glucose of the biological sample contained in the sample container. Measuring means, the first HbA1c measuring means, the second HbA1c measuring means, and the transporting means for transporting the sample container between the glucose measuring means, and the measurement results of the past HbA1c of each patient Comparison means for comparing the stored storage means, the measurement result of HbA1c in the first HbA1c measurement means of a certain patient with the previous measurement result of the patient stored in the storage means, and the comparison means When the comparison result in the step is deviated by a predetermined threshold or more, the transport means transports the sample container to the second HbA1c measurement means. By including, an instruction means for instructing a re-examination of HbA1c of the biological sample of the patient by the second measuring HbA1c means.

  Thus, the first HbA1c measurement means and the second HbA1c measurement means, the glucose measurement means, the transport means for transporting the sample container between them, and the measurement results of the past HbA1c of individual patients are stored. And comparison means for comparing the measurement result of the first HbA1c measurement means of a patient with the previous measurement result of the patient stored in the storage means, and the comparison result of the comparison means is a predetermined threshold value In the case where there is a divergence, the second HbA1c measurement means is caused to convey the sample container by the conveyance means, and the second HbA1c measurement means is provided with the instruction means for instructing reexamination of the biological sample of the patient. As in the case of the above measurement method, the measurement operation of HbA1c can be efficiently performed, and the determination of the re-examination of HbA1c can be performed simply and reliably. It made.

  ADVANTAGE OF THE INVENTION According to this invention, while being able to perform the measurement operation | work of HbA1c efficiently, it has the effect that determination of the reexamination of HbA1c can be performed simply and reliably.

A measurement system according to a first embodiment of the present invention, including a first HbA1c measuring device and a second HbA1c measuring device for measuring HbA1c of a biological sample, and a glucose measuring device for measuring glucose of a biological sample FIG. 16 is a schematic top view of the transport path of the sample rack in FIG. 1 is a first embodiment of the present invention, showing a schematic circuit configuration and contents stored in storage means in a measurement system having a first HbA1c measuring device, a glucose measuring device, and a second HbA1c measuring device. It is a conceptual diagram which shows a part. FIG. 1 is a block diagram showing a measurement system including a first HbA1c measurement device, a glucose measurement device, and a second HbA1c measurement device according to a first embodiment of the present invention. It is a 1st embodiment of the present invention, and is a flow chart which shows an outline of control processing of reexamination. It is a second embodiment of the present invention, and is stored in a schematic circuit configuration and storage means in a measurement system having a host computer, a first HbA1c measuring device, a glucose measuring device, and a second HbA1c measuring device. It is a conceptual diagram which shows a part of content. It is a block diagram which is a 2nd embodiment of the present invention, and shows a host computer, a first HbA1c measuring device, a glucose measuring device, and a second HbA1c measuring device.

  Hereinafter, specific embodiments of the present invention will be described based on the drawings. The dimensions, materials, shapes, relative arrangements, and the like of the components described in the present embodiment are not intended to limit the technical scope of the invention to them unless otherwise specified.

  Here, the case where the present invention is applied to an HbA1c measuring device and a glucose measuring device will be described as an example. However, the present invention can be applied to devices other than the above-described measuring devices, measuring devices for analyzing other components of biological samples, and the like. The description of each embodiment of the measurement system 10 according to the present invention described below also serves as the description of the measurement method according to the present invention and the embodiment of the measurement apparatus.

  As shown in FIG. 1, the measurement system 10 in the present embodiment includes a first HbA1c measurement device 30, a second HbA1c measurement device 70, and a glucose measurement device 50.

The first HbA1c measuring device 30 and the second HbA1c measuring device 70 in the present embodiment use high performance liquid chromatography (HPLC), and the sample container 140 is used as a sample rack 150. Set to automatically measure the concentration of HbA1c in the blood. In the sample rack 150, a plurality of (specifically, ten) sample containers 140 in which blood or the like is stored as a biological sample are erected and held.
The basic configurations of the first HbA1c measurement device 30 and the second HbA1c measurement device 70 can be the same as those of the HbA1c measurement devices known in the related art. At the time of measurement, consumables such as column, eluent and washing solution are used.

  The second HbA1c measurement device 70 is the same device as the first HbA1c measurement device 30 (a device having the same measurement items and configuration). The first HbA1c measuring device 30 and the second HbA1c measuring device 70 are not limited to the same device, and one of them can be a simple device. In addition, it is desirable that the comparison means, the indication means, and the like to be described later are provided in a device that is not a simple device.

In the present embodiment, as shown in FIG. 1, the first HbA1c measuring device 30, the glucose measuring device 50, and the second HbA1c measuring device 70 are arranged in a line.
The measurement system 10 according to the present embodiment is provided with the transport means 94 for transporting the sample rack 150 containing the sample container 140. Specifically, the transport unit 94 includes the transport unit 34 included in the first HbA1c measurement apparatus 30, the transport unit 54 included in the glucose measurement apparatus 50, and the transport unit 74 included in the second HbA1c measurement apparatus 70. doing.

  Between the first HbA1c measuring device 30 and the glucose measuring device 50, a connection member 42 capable of transporting the sample rack 150 from the first HbA1c measuring device 30 to the glucose measuring device 50 is provided. Further, a connection member 62 capable of transporting the sample rack 150 from the glucose measuring device 50 to the second HbA1c measuring device 70 is provided between the glucose measuring device 50 and the second HbA1c measuring device 70. There is.

  The transport means 34 transports the sample rack 150 from the first HbA1c measuring device 30 to the glucose measuring device 50, and further transport means 34a for transporting the sample rack 150 to measure the HbA1c in the first HbA1c measuring device 30. And conveying means 34 b for conveying via the connection member 42.

  The conveying means 54 conveys the sample rack 150 to the second HbA1c measuring device 70 from the glucose measuring device 50, and further, conveying means 54a for conveying the sample rack 150 to measure glucose in the glucose measuring device 50. And conveying means 54b for conveying via the.

  The transport means 74 is for transporting the sample rack 150 to measure HbA1c in the second HbA1c measurement apparatus 70.

  The arrangement of one row of the first HbA1c measuring device 30, the glucose measuring device 50, and the second HbA1c measuring device 70 is not limited to the arrangement of the above-described glucose measuring devices 50 in the center of three units. . For example, the arrangement of the line is arranged in the order of the glucose measuring device 50, the first HbA1c measuring device 30, and the second HbA1c measuring device 70, and the glucose measuring device 50 is arranged at the head, and the first HbA1c measuring device 30 is arranged. May be placed in the center of the three.

  In the present specification, “HbA1c” is one of the protein components of erythrocytes and refers to one in which glucose is bound to the N-terminal end of the β chain of hemoglobin, and unless otherwise stated, stable HbA1c (s-HbA1c) It means that. As components other than stable HbA1c that can be detected when blood or a sample derived from blood is analyzed by separation analysis, hemoglobin A0 (HbA0), hemoglobin A1a (HbA1a), hemoglobin A1b (HbA1b), hemoglobin A2 (HbA2) Hemoglobin S (HbS, Sickle Cell Hemoglobin), Hemoglobin F (HbF, Fetal Hemoglobin), Hemoglobin M (Hb M), Hemoglobin C (Hb C), Hemoglobin D (Hb D), Hemoglobin E (Hb E), Methylated Hemoglobin, carbamyl And hemoglobins, acetylated hemoglobin, unstable HbA1c (1-HbA1c) and the like.

  In the present specification, “measuring HbA1c of a biological sample” refers to measuring the concentration of HbA1c in a biological sample, for example, the ratio of HbA1c to the whole of hemoglobin A in blood which is a biological sample (HbA1c (mole) / Hemoglobin A (mole) is called measuring. The unit of the measurement result is%.

  The transport means 94 (34, 54, 74) is for transporting the sample rack 150 holding the plurality of sample containers 140 upright along a fixed path. The sample rack 150 can be transported by arranging one or more drive belts on the lower surface of the transport means 94 (34, 54, 74).

  In the transport means 34a, when the sample rack 150 is supplied to the frontmost right side of the first HbA1c measurement apparatus 30, the sample rack 150 can be transported in the back direction along the path indicated by the arrow.

Then, the sample rack 150 is transported to the back side and then transported to the left side in the arrow direction, and in this transport process, the bar code reader 33 reads the bar code affixed to the side surface of each sample container and The sampling by the suction nozzle not performed is performed, and the measurement of HbA1c is performed by the HbA1c measurement unit 31 (see FIG. 3) of the first HbA1c measurement apparatus 30, which will be described later. Thereafter, the sample rack 150 is conveyed by the drive belt to the near side in the direction of the arrow, and reaches the frontmost left side of the first HbA1c measurement device 30.
When HbA1c is measured by the HbA1c measurement unit 31 of the first HbA1c measurement device 30, comparison with the previous measurement result of the same patient is performed by the comparison unit 130 described later, and when it deviates by a predetermined threshold or more. The re-examination by the second HbA1c measurement apparatus 70 is instructed by the instruction unit 120 described later, and the re-examination is not instructed if the two do not deviate.

  When the sample rack 150 reaches the frontmost left side of the first HbA1c measuring device 30, the sample rack 150 is conveyed by the conveying means 34b to the left side (the glucose measuring device 50 side) in the arrow direction, and glucose is measured via the connection member 42 The front right side of the device 50 is reached.

  Also in the glucose measuring device 50, the sample rack 150 is transported by the transport means 54 in the same manner as the first HbA1c measuring device 30. That is, when the sample rack 150 is supplied to the rightmost side on the front side of the glucose measuring device 50, the sample rack 150 is transported by the transport means 54a in the back direction along the path indicated by the arrow.

  Then, after the sample rack 150 is transported to the back side, it is transported to the left side in the arrow direction, and in this transport process, the bar code reader 53 reads the bar code affixed to the side surface of the sample container 140 and The sampling by the suction nozzle is performed, and the measurement of glucose by the glucose measurement unit 51 described later is performed. Thereafter, the sample rack 150 is conveyed by the drive belt to the near side in the direction of the arrow, and reaches the foremost left side of the glucose measuring device 50.

The case of re-examining HbA1c by the second HbA1c measurement apparatus 70 will be described below.
When the sample rack 150 reaches the frontmost left side of the glucose measuring device 50, the sample rack 150 is conveyed by the conveying means 54b to the left side in the direction of the arrow (the second HbA1c measuring device 70 side). It reaches the front right side of the HbA1c measurement device 70 of No.2.

  In the second HbA1c measurement apparatus 70, the transport means 74 transports the sample rack 150 as in the first HbA1c measurement apparatus 30. That is, when the sample rack 150 is supplied to the rightmost side of the second HbA1c measurement apparatus 70, the sample rack 150 is transported by the transport means 74 in the direction indicated by the arrow by the transport means 74.

  Then, after the sample rack 150 is transported to the back side, it is transported to the left side in the arrow direction, and in this transport process, the barcode reader 73 reads the barcode affixed to the side surface of the specimen container 140 and The sampling by the suction nozzle is performed, and the measurement of HbA1c in the second HbA1c measurement device 70 is performed. Thereafter, the sample rack 150 is conveyed by the drive belt to the near side in the direction of the arrow, and reaches the foremost left side of the glucose measuring device 50.

  When the re-examination of HbA1c is not instructed by the instruction unit 120, the re-examination is not performed by the second HbA1c measurement apparatus 70, but the transport of the sample rack 150 by the transport unit 74 is similarly performed, and finally Reaches the front left side of the second HbA1c measurement device 70. Of course, the inspection operator may take out the sample rack 150 outside at the final conveyance position (the left side on the near side) of the glucose measuring device 50 without conveying the sample rack 150 to the second HbA1c measuring device 70.

  As shown in FIG. 2, between the first HbA1c measuring device 30 and the second HbA1c measuring device 70, between the first HbA1c measuring device 30 and the glucose measuring device 50, and the second HbA1c measuring device 70. Communication with the glucose measuring device 50 is communicably connected to each other by the communication means 92 (see FIG. 3), and measurement results and measurement status data are formed so as to be able to be transmitted and received.

  Here, the measurement system 10 according to the present embodiment includes storage means 98 for storing various data and the like (see FIG. 3). Specifically, the storage unit 98 includes the storage unit 38 included in the first HbA1c measurement apparatus 30, the storage unit 58 included in the glucose measurement apparatus 50, and the storage unit 78 included in the second HbA1c measurement apparatus 70. doing. In this embodiment, each measuring device has storage means 98 for storing the past measurement results. However, each measuring device is connected by communication means 92 and can transmit and receive data such as measurement results. Therefore, the area portion of the storage means 98 for storing the past measurement results may be provided only in one of the measurement devices, for example, the first HbA1c measurement device 30.

The storage means 38 included in the first HbA1c measurement apparatus 30 includes patient identification information (patient IDs: P1 to Pn) of the patient to be measured at the medical institution where the measurement system 10 according to the present embodiment is provided, The previous measurement values (H1 to Hn) of the patient's previous HbA1c are stored.
Measurement data are mutually transmitted / received between the first HbA1c measurement device 30 and the second HbA1c measurement device 70 so that the same data can be shared. Of course, the data may be stored only in the first HbA1c measurement apparatus 30.
The storage unit 58 of the glucose measurement device 50 stores identification information (patient IDs: P1 to Pn) of the patient and the previous measurement values of glucose (G1 to Gn).

  The first HbA1c measuring device 30, the second HbA1c measuring device 70, and the storage means 98 (38, 58, 78) of the glucose measuring device 50 are not only patient identification information and previous measurement results, but also the patient's The identification information and all measurement results measured in the past of the patient may be stored.

  As shown in FIG. 3, the measurement system 10 according to the present embodiment includes a communication unit 92 capable of exchanging data between the measurement devices by communication. Specifically, the communication means 92 is provided in the communication means 32 provided in the first HbA1c measuring device 30, the communication means 52 provided in the glucose measuring device 50, and the second HbA1c measuring device 70. And communication means 72.

As shown in FIG. 3, the control means 40 of the first HbA1c measurement apparatus 30 is provided with a CPU 37 having a comparison means 130 and an indication means 120, and a storage means 38. The control means 40 comprises communication means 32, HbA1c measurement means 31 (first HbA1c measurement means), bar code reader 33, transport means 34, input means 35, display means 36 are connected.
The comparison means 130 compares the measurement result of HbA1c in the first HbA1c measurement means 31 of a certain patient with the previous measurement result of the patient stored in the storage means 38.

  When the comparison result in the comparison means 130 deviates by a predetermined threshold or more, the instruction means 120 uses the transport means 94 (34, 54, 74) to make a sample rack having a biological sample in the second HbA1c measurement device 70. 150 is conveyed, and the second HbA1c measuring device 70 instructs re-examination of HbA1c of the biological sample.

Here, the predetermined threshold is a numerical value that serves as an indication of whether or not to re-examine HbA1c in the medical institution, and is predetermined in advance by the past experience in the measurement system 10. is there. Of course, the predetermined threshold can be freely set by the medical institution using the measurement system 10.
Specifically, for example, the predetermined threshold is set to 0.2%. In this case, if there is a difference of 0.2% or more between the measured value of HbA1c by the first HbA1c measuring means 31 of a certain patient and the previous measured value of HbA1c of the patient (specifically, If the current measured value (%) of HbA1c is equal to or higher than the previous measured value (%) + 0.2%, or the current measured value (%) of HbA1c is the previous measured value (%) The re-inspection of HbA1c in the second HbA1c measurement apparatus 70 is instructed by the instruction unit 120 when the value is −0.2% or less).
Specifically, for example, when the previous measurement value of HbA1c is 4.0%, the measurement value of HbA1c of this time is 4.2% or more, or the measurement value of HbA1c of this time Is below 3.8%, it will be re-examination.

  In addition, the threshold value serving as a reference for this reexamination is not limited to 0.2% described above, and may be preferably set to 0.5%, for example, to reduce the frequency of reexamination. More preferably, it may be set to 1.0% to reduce the frequency of examinations. That is, in the present embodiment, when the current measurement value of HbA1c deviates from the previous measurement value of HbA1c by 0.2% or more, re-examination is instructed, but the present invention is particularly limited to this numerical value. For example, reexamination may be instructed when there is a deviation of 0.5% or more, or reexamination may be instructed if the deviation is 1.0% or more.

  The communication means 32 of the first HbA1c measurement device 30 can transmit and receive data etc. between the communication means 52 of the glucose measurement device 50 and the communication means 72 of the second HbA1c measurement device 70.

  The HbA1c measurement means 31 (first HbA1c measurement means) of the first HbA1c measurement device 30 is for measuring the HbA1c of the biological sample in the first HbA1c measurement device 30, as described above. The HbA1c concentration is measured by the HPLC method.

  The bar code reader 33 of the first HbA1c measurement apparatus 30 receives the sample container 140 when the sample container 140 uprightly held by the sample rack 150 is transported to the front side of the barcode reader 33 by the transport means 34 a. The patient identification information affixed to the side of the document is for reading a bar code described therein.

  The transport means 34b of the first HbA1c measurement device 30 transports the sample rack 150 to the glucose measurement device 50 from the upstream side of the transport direction of the first HbA1c measurement device 30, as described above.

  The input means 35 of the first HbA1c measurement device 30 is a portion used to input data necessary for analysis or to select a selection item displayed on the display means 36. As a specific example of the input means 35, a keyboard, a mouse, a touch panel etc. are mentioned. Specific examples of the input data include, for example, patient ID numbers, analysis items, parameters required for analysis, and the like.

  The display means 36 of the first HbA1c measurement device 30 displays, for example, selection items necessary for analysis and analysis results. A liquid crystal monitor is used as the display means 36, but a simple display device using a plurality of seven-segment LEDs may be used.

  The control unit 60 of the glucose measuring apparatus 50 is provided with a CPU 57 and a storage unit 58. The control unit 60 includes a communication unit 52, a glucose measurement unit 51, a bar code reader 53, a transport unit 54, and an input unit 55. , And display means 56 are connected.

  The CPU 57 of the glucose measuring device 50 is an arithmetic processing unit in the glucose measuring device 50, and does not have the comparison means 130 and the indication means 120 as described above. The comparison means 130 and the indication means 120 may be included in the glucose measurement device 50 instead of the first HbA1c measurement device 30.

  The storage means 58 of the glucose measurement device 50 stores the past glucose measurement results for each patient. In addition, although the memory | storage means 58 memorize | stores the last measurement result, it is not limited to this in particular, You may make it memorize all the measurement results measured in the past regarding the said patient.

  The communication means 32 of the glucose measurement device 50 can transmit and receive data etc. between the communication means 32 of the first HbA1c measurement device 30 and the communication means 72 of the second HbA1c measurement device 70.

  The glucose measuring means 51 of the glucose measuring device 50 is for measuring glucose of a biological sample, and specifically, an enzyme electrode method in which a glucose concentration is combined with a glucose oxidase immobilized enzyme membrane and a hydrogen peroxide electrode It measures with. The glucose concentration is a so-called blood sugar level, and the unit is mg / dL.

  The transport means 54 (54a, 54b) of the glucose measuring device 50 transports the sample rack 150 to the second HbA1c measuring device 70 from the upstream side of the transporting direction of the glucose measuring device 50 as described above. .

  The bar code reader 53, the input means 55, and the display means 56 of the glucose measurement device 50 are the same as the bar code reader 33, the input means 35, and the display means 36 described in the first HbA1c measurement device 30.

  The control unit 80 of the second HbA1c measuring apparatus 70 is provided with a CPU 77 and a storage unit 78. The control unit 80 includes a communication unit 72, an HbA1c measuring unit 71 (a second HbA1c measuring unit), and a bar. A code reader 73, transport means 74, input means 75, and display means 76 are connected.

  The CPU 77 of the second HbA1c measurement device 70 is an arithmetic processing unit in the second HbA1c measurement device 70 and does not have the comparison means 130 and the indication means 120 as described above, but the comparison means 130 and the indication means The second HbA1c measurement device 70 may have 120 instead of the first HbA1c measurement device 30.

  The storage unit 78, the communication unit 72, the HbA1c measurement unit 71 (the second HbA1c measurement unit), the bar code reader 73, the transport unit 74, the input unit 75, and the display unit 76 of the second HbA1c measurement device 70 are the first It is the same as each means described in the HbA1c measurement apparatus 30. Although the storage unit 78 of the second HbA1c measurement device 70 stores the measurement results of the previous HbA1c in the same manner as the storage unit 38 of the first HbA1c measurement device 30, the storage unit 78 of the first HbA1c measurement device 30 By transmitting measurement data to the storage unit 38 and storing it, the storage unit 78 of the second HbA1c measurement apparatus 70 may not store the past measurement results.

  Based on the flowchart shown in FIG. 4, the outline | summary of the control process of the reexamination which the measurement system 10 which concerns on this Embodiment performs is demonstrated. In addition, the said process is a process regarding the biological sample of the same patient.

  First, in step 110, the first HbA1c measurement apparatus 30 measures HbA1c in the blood of a patient among the biological samples stored in the sample container 140 of the sample rack 150. Then, the process proceeds to the next step 111.

  In step 111, the comparison means 130 compares the measurement result of the first HbA1c measurement device 30 of the patient with the previous measurement result of the patient, specifically, the first HbA1c. It is determined whether or not the value of HbA1c measured by the measuring device 30 deviates 0.2% or more which is a predetermined deviation condition from the value of HbA1c previously measured of the same patient stored in the storage means 38 . If it is determined that the current HbA1c measurement result deviates from the previous measurement result by a predetermined deviation condition or more, the process proceeds to the next step 112, and if it is determined that the HbA1c does not deviate, the process proceeds to step 114.

In step 112, glucose of the patient's biological sample is measured by the glucose measuring device 50, and then the instruction container 120 conveys the sample container 140 to the second HbA1c measuring device 70 to instruct retesting of the HbA1c. Then, the process proceeds to the next step 113.
In step 113, measurement (re-examination) of HbA1c is performed by the second HbA1c measurement apparatus 70. Then, the process ends.
If it is determined in step 111 that the current HbA1c measurement result does not deviate from the previous measurement result by a predetermined deviation condition or more, glucose in the patient's biological sample is measured by the glucose measuring device 50 in step 114. Ru. Then, the process ends.

  The above-described processing procedure is processing for the same patient, and even when a plurality of sample containers 140 of different patients are included in the sample rack 150, the processing procedure for the same patient is the above-described processing procedure. It is a thing.

  In the case where a plurality of sample containers 140 of different patients are included in the sample rack 150, when the sample rack 150 is transported to each measurement position in each measurement device, all the sample containers 140 at that measurement position. The sampling and measurement are performed on the biological sample of As a result, if one of the sample containers 140 is retested and the other sample containers 140 are not retested, the sample rack 150 is transported along the transport route in the case of retesting. However, for each sample container 140, one to be re-inspected by the barcode reader 73 is distinguished from one not to be re-inspected, and only the sample container 140 to be re-inspected is to be subjected to the re-examination of HbA1c.

  In the present embodiment, by having the above-described configuration, the following actions and effects are achieved.

  In this embodiment, when the measurement result of HbA1c in the first HbA1c measurement device 30 of a certain patient deviates by a predetermined threshold or more as compared with the previous measurement result of the patient (specifically, The sample container 140 of the sample rack 150 is transported to the second HbA1c measuring device 70 by the transport means 94 (34, 54, 74) by the transport means 94 (when separated by 0.2% or more). Re-examination of HbA1c by the HbA1c measurement apparatus 70 of FIG. Then, based on the instruction, the second HbA1c measurement device 70 executes the re-examination of the HbA1c.

  For example, when the HbA1c measurement apparatus is operated individually, and the present embodiment is compared with what is judged by a doctor or a person in charge of examination each time based on the measurement result each time, the present embodiment The two HbA1c measuring devices can be linked without intervention of the judgment of a doctor or a person in charge of inspection every time, and the execution of the re-examination of HbA1c can be uniformly processed in a short time in a large amount. .

  That is, according to the present embodiment, it is not necessary for the doctor or the person in charge of inspection to judge the measurement result each time, and therefore, it is uniformly processed accurately and in large quantities without being affected by artificial judgment errors or the like. It is possible to

  As described above, based on the comparison results of the measurement results, HbA1c measurement work can be efficiently performed by enabling execution of transport, re-examination instructions, and execution of a biological sample of the same patient as a series of processes. It is possible to easily and reliably execute the determination of the re-examination of HbA1c.

In the present embodiment, communication means 92 (32, 52, 72) capable of transmitting and receiving measurement results between the first HbA1c measuring device 30 and the second HbA1c measuring device 70 are provided, and the memory means 38, the comparing means 130. And, since the instruction means 120 is provided in the first HbA1c measuring device 30, a plurality of measuring devices can be operated and managed as one system without separately providing a dedicated host computer 20 for managing them. can do.
The storage unit 98, the comparison unit 130, and the instruction unit 120 may be provided in the glucose measuring device 50 or the second HbA1c measuring device 70.

Second Embodiment
Next, a second embodiment will be described using FIGS. 5 and 6.
In the first embodiment described above, the instruction unit 120 and the comparison unit 130 are provided in the first HbA1c measurement device 30, but in the measurement system 10 according to the present embodiment, the first HbA1c measurement device 30, the first HbA1c measurement device 30, The host computer 20 to which the HbA1c measurement device 70 and the glucose measurement device 50 are connected is provided, and the host computer 20 is different in that the storage unit 98, the comparison unit 130, and the instruction unit 120 are provided.

  The description will be made focusing on parts different from the above-described first embodiment, and the description of overlapping parts will be simplified or omitted.

As shown in FIG. 5, the host computer 20, the first HbA1c measurement device 30, the second HbA1c measurement device 70, and the glucose measurement device 50 are communicably connected to each other, and measurement is performed. The result and data of the measurement situation are formed to be able to transmit and receive.
The storage unit 110 of the host computer 20 described later includes patient identification information (patient ID: P1 to Pn) of a patient to be measured at a medical institution where the measurement system 10 according to the present embodiment is provided, The measured values (H1 to Hn) of HbA1c and the measured values (G1 to Gn) of the previous glucose are stored.
The HbA1c data is also stored in the first HbA1c measurement device 30 and the second HbA1c measurement device 70.
Also, in the glucose measuring device 50, data relating to glucose is stored.

As shown in FIG. 6, the first HbA1c measurement device 30, the second HbA1c measurement device 70, and the glucose measurement device 50 are information in a medical institution built in the medical institution where each device is installed. The host computer 20 is connected through a line such as a communication network (LAN) or the Internet.
The host computer 20 includes an instruction unit 120, a comparison unit 130, and a storage unit 110.
Although the host computer 20 is provided with all the instruction means 120 and the comparison means 130, the present invention is not limited to this. The host computer 20 is provided with a part of the comparison means 130 and the instruction means 120, and the rest is the first HbA1c The measuring device 30 or the like may be provided.

According to this embodiment, the first HbA1c measurement device 30, the second HbA1c measurement device 70, and the glucose measurement device 50 are connected to the host computer 20, and the measurement results are transmitted from the measurement devices to the host computer 20. By providing the host computer 20 having the storage unit 110, the comparison unit 130, and the instruction unit 120, the host computer 20 can store and collectively manage the measurement results of these measurement devices. .
The other configurations, operations, and effects are substantially the same as those in the first embodiment, and thus the description thereof is omitted.

DESCRIPTION OF SYMBOLS 10 measurement system 20 host computer 30 1st HbA1c measuring apparatus 31 1st HbA1c measuring means 32 communication means 33 bar code reader 34 (34a, 34b) conveyance means 35 input means 36 display means 37 CPU
38 storage means 40 control means 42 connection member 50 glucose measuring device 51 glucose measurement means 52 communication means 53 bar code reader 54 (54a, 54b) transport means 55 input means 56 display means 57 CPU 58 storage means 60 control means 62 connection member 70 Second HbA1c measuring device 71 Second HbA1c measuring device 72 Communication device 73 Bar code reader 74 Transport device 75 Input device 76 Display device 77 CPU
78 storage means 80 control means 92 communication means 94 transport means 98 storage means 110 storage means 120 instruction means 130 comparison means 140 sample container 150 sample rack

Claims (5)

A first HbA1c measuring device and a second HbA1c measuring device for measuring HbA1c of a biological sample housed in a sample container, and a glucose measuring device for measuring glucose of the biological sample housed in the sample container,
A measurement system capable of measuring HbA1c of the biological sample with the second HbA1c measurement device after measuring HbA1c of the biological sample with the first HbA1c measurement device,
Transport means for transporting the sample container among the first HbA1c measuring device, the second HbA1c measuring device, and the glucose measuring device;
Storage means for storing the past HbA1c measurement results of the individual patients;
First HbA1c measurement means for measuring HbA1c of the biological sample by the first HbA1c measurement device;
Comparison means for comparing the measurement result of HbA1c in the first HbA1c measurement means of a certain patient with the previous measurement result of the patient stored in the storage means;
When the comparison result in the comparison means deviates by a predetermined threshold or more, the sample container is transported to the second HbA1c measuring device using the transporting means, and the biological sample is collected by the second HbA1c measuring device. Instruction means for instructing re-examination of HbA1c;
And a second HbA1c measurement unit configured to measure the HbA1c of the biological sample of the patient with the second HbA1c measurement device based on the instruction of the instruction unit. Communication means capable of transmitting and receiving measurement result data between the first HbA1c measuring device and the second HbA1c measuring device is provided,
The measurement system according to claim 1, wherein the storage unit, the comparison unit, and the instruction unit are provided in any one of the first HbA1c measurement device and the second HbA1c measurement device. A host computer to which the first HbA1c measurement device and the second HbA1c measurement device are connected;
Data of measurement results can be transmitted from the first HbA1c measuring device and the second HbA1c measuring device to the host computer,
The measurement system according to claim 1, wherein the storage unit, the comparison unit, and the instruction unit are provided in the host computer. A first HbA1c measuring device and a second HbA1c measuring device for measuring HbA1c of a biological sample housed in a sample container, and a glucose measuring device for measuring glucose of the biological sample housed in the sample container,
A method of measuring HbA1c of the biological sample after measuring HbA1c of the biological sample with the first HbA1c measuring device, and then measuring HbA1c of the biological sample with the second HbA1c measuring device,
A first HbA1c measuring step of measuring HbA1c of the biological sample of a patient by the first HbA1c measuring device;
Comparing the measurement result in the first HbA1c measurement step with the previous measurement result of the patient;
When the comparison result in the comparison step deviates by a predetermined threshold or more, the second HbA1c measuring device is caused to convey the sample container to the second HbA1c measuring device using the conveying means for conveying the sample container. An instruction step of instructing reexamination of the biological sample of the patient according to
A second HbA1c measurement step of measuring the HbA1c of the biological sample of the patient with the second HbA1c measurement device based on the instruction. First HbA1c measuring means and second HbA1c measuring means for measuring HbA1c of a biological sample housed in a sample container;
Glucose measuring means for measuring glucose of the biological sample contained in the sample container;
Transport means for transporting the sample container among the first HbA1c measurement means, the second HbA1c measurement means, and the glucose measurement means;
Storage means for storing the past HbA1c measurement results of the individual patients;
Comparison means for comparing the measurement result of HbA1c in the first HbA1c measurement means of a certain patient with the previous measurement result of the patient stored in the storage means;
When the comparison result in the comparison means deviates by a predetermined threshold or more, the sample container is transported by the second HbA1c measurement means by the transport means, and the biological sample of the patient by the second HbA1c measurement means An instruction means for instructing re-examination of HbA1c;