JP2018191725A - Biological information measuring device and control method of biological information measuring device - Google Patents

Abstract

To estimate biological information more accurately by decreasing distortion in an electrocardiographic waveform and measuring a more accurate pulse wave propagation time.SOLUTION: A biological information measuring device includes: electrocardiogram detection means having an electrode made of a flexible conductive member for detecting an electrocardiographic signal of an electrocardiographic wave of a living body, for outputting the electrocardiographic signal detected by the electrode; pulse wave detection means for detecting a pulse wave signal of a pulse wave generated from a blood vessel in the living body and outputting the detected pulse wave signal; sensor mounting means provided with the electrode of the electrocardiogram detection means on at least a part of it, which is to be mounted on the living body; and a control part for controlling the electrocardiogram detection means and the pulse wave detection means, which includes biological information calculation means for calculating biological information on the living body based on the electrocardiographic signal and the pulse wave signal.SELECTED DRAWING: Figure 1

Description

  The present invention relates to a biological information measuring apparatus and a biological information measuring apparatus control method for non-invasively measuring biological information of a biological body.

  Conventionally, there has been proposed an electrocardiogram electrode that can acquire a highly accurate electrocardiogram even when the subject moves without restraining the subject (see, for example, Patent Document 1). In the electrocardiogram electrode, a conductive fabric formed by weaving conductive fibers is sewn into the shoulder portion of the clothes, which is always in direct contact with the body surface of the subject.

In addition, a biological interface has been proposed that maintains comfort and allows electrodes to be easily installed on the body surface of a subject (for example, see Patent Document 2). This biological interface is composed of a patch type electrode made of a composite material of a conductive polymer and a fiber, and a fixing material made of a dressing material, and a shape memory property between the patch type electrode and the fixing material. A layer portion is provided.

JP-A-11-128187 Japanese Patent Laid-Open No. 2006-87116

  However, these conventional techniques are mainly intended to collect electrocardiograms, and are not sufficiently optimized when the electrocardiographic waveform is used for another vital sign monitor (for example, a sphygmomanometer).

That is, when estimating the blood pressure using the time difference between the peak of the electrocardiogram waveform and the peak of the pulse wave, that is, the pulse wave propagation time, in order to obtain this time accurately, obtain a waveform that is as sharp and smooth as possible. However, the conventional electrocardiogram detection electrode has a problem that the capacitance component is large and the waveform is dull.

  An object of the present invention is to provide a biological information measuring device capable of measuring biological information with higher accuracy by reducing the dullness of an electrocardiographic waveform and measuring a pulse wave propagation time with higher accuracy.

A biological information measuring device according to an embodiment of one aspect of the present invention is provided.
A biological information measuring apparatus for non-invasively measuring biological information of a living body, comprising an electrode made of a flexible conductive member for detecting an electrocardiogram signal of the living body's electrocardiogram, and the electrode An electrocardiogram detection means for outputting the electrocardiogram signal detected by the method, a pulse wave detection means for detecting a pulse wave signal of a pulse wave generated from a blood vessel in the living body, and outputting the detected pulse wave signal; In part, the electrode of the electrocardiogram detection means is provided, a sensor wearing means for the living body to wear, and a controller for controlling the electrocardiogram detection means and the pulse wave detection means, the heart And a control unit having biological information calculation means for calculating biological information of the living body based on the electric signal and the pulse wave signal.

  In the biological information measuring apparatus, the flexible conductive member is a woven fabric, a knitted fabric or a non-woven fabric composed of a multifilament yarn made of a thermoplastic polymer having a single fiber diameter of 100 nm to 1000 nm. A conductive material is contained on the surface or a gap between the single fiber and the single fiber.

  In the biological information measuring apparatus, the thermoplastic polymer is polyester.

  In the biological information measuring apparatus, the conductive substance is a conductive polymer.

  In the biological information measuring device, the conductive substance is a conductive resin paste of a low-conductivity polymer containing at least one of carbon black, carbon nanotube, and metal fine particles, or a conductive resin. It is characterized by.

  In the biological information measuring apparatus, the capacitance component of the impedance of the electrode is in the range of 0.001 μF to 0.1 μF.

  In the biological information measuring apparatus, the capacitance component of the contact impedance between the electrode and the biological surface is in the range of 0.001 μF to 0.1 μF.

  In the biological information measuring apparatus, the electrocardiogram detection means and the pulse wave detection means are arranged on the surface of the living body.

  In the biological information measuring apparatus, the sensor wearing means is a garment worn by the living body.

  In the biological information measuring device, the clothes are wristbands.

In the biological information measuring device, the electrocardiogram signal and the pulse wave signal are detected and amplified, and further provided with signal detection means for analog-to-digital conversion and output of the amplified signal,
The biological information calculation means calculates the biological information of the living body based on the electrocardiogram signal and the pulse wave signal after digital conversion output from the signal detection means.

  In the biometric information measuring apparatus, the electrocardiogram detection part of the living body where the electrocardiogram detection means detects the electrocardiogram signal is any one or more of a wrist, a palm, a finger, a second arm, an ear, and a neck of the living body. It is characterized by that.

  In the biological information measuring apparatus, the pulse wave detection part of the living body where the pulse wave detection means detects a pulse wave signal is any one or more of a wrist, a palm, a finger, a second arm, an ear, and a neck of the living body. It is characterized by.

  In the biological information measuring apparatus, the control unit stores a program for controlling the electrocardiogram detection unit and the pulse wave detection unit, and stores a calculation result of the biological information calculated by the biological information calculation unit. A storage means is provided.

  The biological information measuring device further includes biological information output means for outputting the biological information to the outside.

  In the biological information measuring apparatus, the biological information output means includes a display unit that displays the biological information on a screen.

  In the living body information measuring apparatus, the living body information is a blood pressure value of the living body.

  In the biological information measuring apparatus, the pulse wave detecting means includes a light emitting unit that irradiates light on the blood vessels of the living body, a light detection unit that detects scattered light that is reflected or transmitted by the blood vessels on the irradiated light. The pulse wave detection means includes a pulse wave corresponding to the scattered light amount of the scattered light that has changed with the volume change of the blood vessel of the living body based on the relationship between the irradiation light and the reflected or transmitted scattered light. Is detected.

  The biological information measuring device further includes biological information transmission means for transmitting the biological information calculated by the biological information calculation means to the biological information output means.

  The biological information measuring apparatus further comprises detection information transmission means for transmitting the electrocardiogram signal detected by the electrocardiogram detection means and the pulse wave detection means and information of the pulse wave signal to the control unit. To do.

  In the biological information measuring apparatus, the electrocardiogram detection unit and the pulse wave detection unit are integrally configured.

  In the biological information measuring apparatus, the signal detection unit is configured integrally with the electrocardiogram detection unit and the pulse wave detection unit.

In the biological information measuring apparatus, the biological information calculating means determines a predetermined first reference time point of an electrocardiogram of the electrocardiographic signal detected by the electrocardiogram detecting means and detects the pulse wave detecting means. Determining a predetermined second reference time point of the pulse wave of the pulse wave signal, calculating a pulse wave propagation time Tt from a time difference between the second reference time point and the first reference time point, and calculating the pulse wave propagation time. Based on the above, the blood pressure value BP _{t of the} living body is calculated using the following equation (1).

In the above formula (1), K ₁ and K ₂ are constants.

In the biological information measuring apparatus, the biological information calculation unit corrects the pulse wave propagation time by subtracting a predetermined delay time from the pulse wave propagation time, and based on the corrected pulse wave propagation time. The blood pressure value BP _{t of the} living body is calculated using Equation (1).

  In the biological information measuring apparatus, the delay time is a sum of a delay time specific to the circuit constituting the pulse wave detecting means and a delay time specific to the living body.

  In the biological information measuring apparatus, the biological information calculation means determines the second reference time point from a waveform obtained by first-order differentiation of the pulse wave signal of the pulse wave detected by the pulse wave detection means with time. It is characterized by.

  A method for controlling a biological information measuring device according to an embodiment of the present invention includes an electrode made of a flexible conductive member for detecting an electrocardiographic signal of a living body's electrocardiogram, and is detected by the electrode. At least a part of the electrocardiogram detection means for outputting the electrocardiogram signal, the pulse wave detection means for detecting the pulse wave signal of the pulse wave generated from the blood vessel in the living body, and outputting the detected pulse wave signal The biological information measuring device is provided with the electrode of the electrocardiogram detection means, and includes a sensor wearing means for the living body to wear, and a controller for controlling the electrocardiogram detection means and the pulse wave detection means The electrocardiogram detection means detects the electrocardiogram signal detected by the electrode made of the flexible conductive member, the pulse wave detection means detects the pulse wave signal, and the control By the biometric information calculating means Based on the electrocardiographic signal and the pulse wave signal, and calculates the biological information of the living body.

  The biological information measuring device according to one embodiment of the present invention can improve adhesion with a living body by using a flexible conductive member as an electrode for detecting an electrocardiogram, reduce the area of the electrode, Therefore, it is possible to measure biological information using a highly accurate pulse wave propagation time.

FIG. 1 is a block diagram showing an example of the configuration of the biological information measuring apparatus 100 according to the first embodiment. FIG. 2 is a diagram showing an example of the external appearance of the configuration of the unit U and the sensor wearing means C of the biological information measuring apparatus 100 shown in FIG. FIG. 3 is a diagram showing an example of the configuration inside the sensor wearing means C of the biological information measuring apparatus 100 shown in FIG. FIG. 4 is a diagram showing an example of wearing the living body (right hand) of the unit U and the sensor wearing means C of the biological information measuring apparatus 100 shown in FIG. FIG. 5 is a diagram illustrating an example in which the sensor wearing means C of the biological information measuring apparatus 100 shown in FIG. 1 is worn on a living body (left hand). FIG. 6 is a diagram showing an example of the appearance of the electrocardiogram detection means ED of the biological information measuring apparatus 100 shown in FIG. FIG. 7 is a diagram showing an example of an equivalent circuit of the electrode X of the electrocardiogram detection means ED of the biological information measuring apparatus 100 shown in FIG. FIG. 8 is a diagram showing an example of an electrocardiogram detected by the electrocardiogram detection means ED. FIG. 9 is a diagram showing an example of the measured values of the combined resistance and combined capacitance of the electrode X of the electrocardiogram detection means ED according to the embodiment and the measured values of the combined resistance and combined capacitance of the conventional gel electrode. This is a value measured by an impedance meter with the electrodes facing each other. FIG. 10 is a diagram illustrating an example of an electrocardiogram S1 detected by the electrode X of the electrocardiogram detection unit ED according to the embodiment and an electrocardiogram S2 detected by a conventional gel electrode. FIG. 11 is a model diagram showing an example of a configuration in which a pulse wave is detected by the pulse wave detecting means PD of the biological information measuring apparatus 100 shown in FIG. FIG. 12 is a waveform diagram showing an example of a pulse wave detected by the pulse wave detection means PD. FIG. 13 is a diagram showing an example of the relationship between the first reference time B1 of the cardiac radio wave and the second reference time B2 of the pulse wave set by the biological information calculation means IC and the pulse wave propagation time Tt. FIG. 14 is a diagram illustrating an example of the relationship between the blood pressure value and the pulse wave propagation time Tt. FIG. 15 is a block diagram illustrating an example of a configuration of the biological information measuring apparatus 100 according to the second embodiment.

  Hereinafter, embodiments according to the present invention will be described with reference to the drawings.

(First embodiment)
FIG. 1 is a block diagram showing an example of the configuration of the biological information measuring apparatus 100 according to the first embodiment. 2 is a diagram showing an example of the external appearance of the configuration of the unit U and the sensor wearing means C of the biological information measuring apparatus 100 shown in FIG. FIG. 3 is a diagram showing an example of a configuration inside the sensor wearing means C of the biological information measuring apparatus 100 shown in FIG. FIG. 4 is a diagram showing an example of wearing the living body (right hand) of the unit U and the sensor wearing means C of the biological information measuring apparatus 100 shown in FIG. Moreover, FIG. 5 is a figure which shows the example of wearing to the biological body (left hand) of the sensor wear means C of the biological information measuring device 100 shown in FIG.

  For example, as shown in FIGS. 1 to 5, the biological information measuring apparatus 100 according to the first embodiment includes an electrocardiogram detection means ED, a pulse wave detection means PD, a sensor wearing means C, and a signal detection means SD. Storage means M, biological information transmission means IT, biological information output means IO, and control unit CON.

  This biological information measuring apparatus 100 is configured to measure biological information of a living body noninvasively. In the present embodiment, the signal detection means SD, the storage means M, the biological information transmission means IT, and the control unit CON constitute a unit U.

  Here, the electrocardiogram detection means ED shown in FIG. 1 has an electrode X made of a flexible conductive member for detecting an electrocardiogram signal SE of a living body's electrocardiogram. The electrocardiogram detection means ED outputs an electrocardiogram signal SE detected by the electrode X.

  The electrocardiogram detection part of the living body for the electrocardiogram detection means ED to detect the electrocardiogram signal SE is, for example, any one or more of the wrist, palm, finger, second arm, ear, and neck of the living body.

  Here, FIG. 6 is a diagram showing an example of the appearance of the electrocardiogram detection means ED of the biological information measuring apparatus 100 shown in FIG.

  The flexible conductive member constituting the electrode X of the electrocardiogram detection means ED is composed of, for example, a multifilament yarn made of a thermoplastic polymer having a single fiber diameter of 100 nm or more and 1000 nm or less. For example, as shown in FIG. Further, a woven fabric, a knitted fabric or a non-woven fabric, and a conductive substance is contained in the surface of the single fiber or in the gap between the single fiber and the single fiber.

  The conductive material described above is, for example, a conductive polymer. More specifically, the conductive material is not particularly limited as long as it is a conductive material. However, in consideration of supporting on a fiber, a conductive resin in which carbon black, CNT, metal fine particles, etc. are contained in a low conductive polymer. A conductive polymer in which the paste and resin itself are conductive is preferably used. For example, PEDOT / PSS (Shin-Etsu Polymer Co., SEP LYGIDA (registered trademark)) obtained by doping PEDOT of a thiophene-based conductive polymer with poly 4-styrene sulfonate PSS is preferably used for the conductive material.

  Moreover, the thermoplastic polymer which is the above-mentioned fiber will not be specifically limited if it is a polymer which can be fiberized by a known method, For example, polyester is used suitably.

  Here, FIG. 7 is a diagram showing an example of an equivalent circuit of the electrode X of the electrocardiogram detection means ED of the biological information measuring apparatus 100 shown in FIG. FIG. 8 is a diagram showing an example of an electrocardiogram detected by the electrocardiogram detection means ED.

For example, as shown in FIG. 7, the electrocardiogram detection means ED has a resistance R _{S in the} plane direction, a resistance R _{V in the} thickness direction, and a capacitance C _V. A contact resistance R _C and a contact capacitance C _C exist between the electrode X of the electrocardiogram detection means ED and the living body surface HF. Note that the biometric H shall be present inside the body resistance R _B and the body capacitance C _B.

Capacitance component of the impedance of the electrode X of the electrocardiographic detecting means ED (combined capacitance of the capacitance _{C V)} is in the range of 0.001μF of 0.1ĩF.

Furthermore, (combined capacitance _{C C)} capacitance component of the contact impedance between the electrode X and the biological surface HF electrocardiographic detecting means ED is in the range of 0.001μF of 0.1ĩF.

  The electrocardiogram shown in FIG. 8 is detected by the electrode X of the electrocardiogram detection means ED having such a capacitance.

  Here, a difference in characteristics of detecting an electrocardiogram between the electrode X of the electrocardiogram detection means ED according to the embodiment and a conventional gel electrode will be examined. FIG. 9 is a diagram showing an example of the measured values of the combined resistance and combined capacitance of the electrode X of the electrocardiogram detection means ED according to the embodiment, and the measured values of the combined resistance and combined capacitance of the conventional gel electrode. FIG. 10 is a diagram showing an example of an electrocardiogram S1 detected by the electrode X of the electrocardiogram detection means ED according to the embodiment and an electrocardiogram S2 detected by a conventional gel electrode. In the examples of FIGS. 9 and 10, a sample having an electrode part size of 40 mm × 40 mm is adopted as the electrode X made of a flexible conductive member of the electrocardiogram detection means ED.

  For example, as shown in FIG. 9, the electrode X made of a flexible conductive member of the electrocardiogram detection unit ED according to the embodiment has a capacitance measured at a frequency of 1 kHz is 0.003 μF.

  On the other hand, in the conventionally used gel electrode, the capacitance measured at a frequency of 1 kHz is 0.2 μF.

  As described above, the electrode X made of the flexible conductive member of the electrocardiogram detection means ED can be set to have a very small electrostatic capacity as compared with the conventional electrode.

  As shown in FIG. 10, the peak of the waveform of the electrocardiogram S1 detected by the electrode X of the electrocardiogram detection means ED according to the embodiment changes more sharply than the electrocardiogram S2 detected by the conventional gel electrode. I understand that.

  Thus, since the electrode X made of the flexible conductive member of the electrocardiogram detection means ED can reduce the capacitance, the waveform of the electrocardiogram becomes sharp and the first reference time (for example, the R wave) Peak) detection accuracy can be improved.

  Further, the pulse wave detection means PD shown in FIG. 1 detects a pulse wave signal SP of a pulse wave generated from a blood vessel in a living body, and outputs the detected pulse wave signal SP.

  Here, FIG. 11 is a model diagram illustrating an example of a configuration in which a pulse wave is detected by the pulse wave detection unit PD of the biological information measuring apparatus 100 illustrated in FIG. FIG. 12 is a waveform diagram showing an example of a pulse wave detected by the pulse wave detection means PD.

  The “pulse wave” referred to here is a waveform of a change in blood vessel volume in the peripheral vascular system accompanying the beat of the heart of a living body. For example, when the blood pressure rises, the pulse wave peak value rises. On the other hand, when the blood pressure decreases, the pulse wave peak value decreases.

  For example, as shown in FIG. 11, the pulse wave detection means PD detects a scattered light reflected by the blood vessel by a light emitting unit (LED element) PD1 that irradiates light on the blood vessel of the living body and the irradiated light. Part (photodiode) PD2.

  The pulse wave detecting means PD then detects the scattered light that has changed with the volume change of the blood vessel of the living body based on the relationship between the light output from the light emitting unit (LED element) PD1 and the scattered light reflected by the blood vessel of the living body. A pulse wave (FIG. 12) corresponding to the amount of scattered light is detected.

  The pulse wave detection part of the living body from which the pulse wave detecting means PD detects the pulse wave signal SP is, for example, any one or more of the wrist, palm, finger, second arm, ear, and neck of the living body.

  Here, for example, as shown in FIG. 3, the pulse wave detection means PD and the electrocardiogram detection means ED may be configured integrally with the sensor wearing means C.

  The sensor wearing means C is provided with at least a part of the electrode X of the electrocardiogram detection means ED and the pulse wave detection means PD. This sensor wearing means C is for a living body to wear, and is, for example, clothes worn by a living body.

  This clothing is, for example, a wristband as shown in FIGS. For example, as shown in FIG. 2, the electrocardiogram detection means ED and the pulse wave detection means PD are arranged on the surface of the living body when the sensor wearing means C is worn on the living body.

  The signal detection means SD shown in FIG. 1 includes a detection / amplification circuit and a digital conversion circuit (not shown). The signal detection means SD detects and amplifies the electrocardiogram signal SE and the pulse wave signal SP output from the electrocardiogram detection means ED and the pulse wave detection means PD, and converts the amplified signal from analog to digital. It is designed to output.

  The signal detection means SD may be included in the unit U, and may be configured integrally with the electrocardiogram detection means ED and the pulse wave detection means PD, for example, as shown in FIG.

  In addition, the storage unit M illustrated in FIG. 1 stores a program for the control unit CON to control the biological information output unit IO, the electrocardiogram detection unit ED, and the pulse wave detection unit PD. Further, the storage means M stores the calculation result of the biological information calculated by the biological information calculation means IC.

  The storage means M is, for example, a nonvolatile memory such as a NAND flash memory.

Further, the control unit CON shown in FIG. 1 reads a program stored in the storage unit M, and controls the biological information output unit IO, the electrocardiogram detection unit ED, and the pulse wave detection unit PD.

  The control unit CON includes a biological information calculation unit IC that calculates biological information of the living body based on the electrocardiogram signal SE and the pulse wave signal SP.

  This biological information calculation means IC calculates biological information of the living body based on the electrocardiogram signal SE and the pulse wave signal SP after digital conversion output from the signal detection means SD. The biological information is, for example, a blood pressure value of the living body that can be calculated by using, for example, a pulse wave velocity method as described later, but can be calculated based on the electrocardiogram signal SE and the pulse wave signal SP. Other information on the living body may be used.

  Further, the biological information transmission means IT transmits the biological information calculated by the biological information calculation means IC to the biological information output means.

  The biometric information output means IO outputs the biometric information transmitted from the biometric information transmission means IT to the outside.

  The biological information output means IO includes a display unit Z that displays biological information on the screen. This display part Z is a display panel of a tablet or a personal computer, for example.

  Here, an example in which the biological information calculation means IC calculates a blood pressure value using the pulse wave velocity method will be described. FIG. 13 is a diagram showing an example of the relationship between the first reference time B1 of the cardiac radio wave and the second reference time B2 of the pulse wave set by the biological information calculation means IC and the pulse wave propagation time Tt. FIG. 14 is a diagram illustrating an example of the relationship between the blood pressure value and the pulse wave propagation time Tt.

  For example, the biological information calculation means IC determines a predetermined first reference time point B1 of the electrocardiogram of the electrocardiogram signal SE detected by the electrocardiogram detection means ED (FIG. 13).

  Then, the biological information calculation means IC determines a predetermined second reference time point B2 of the pulse wave of the pulse wave signal SP detected by the pulse wave detection means PD (FIG. 13). The biological information calculation unit IC may determine the second reference time point B2 from a waveform obtained by first-order differentiation of the pulse wave signal detected by the pulse wave detection unit PD with time. .

  Then, the biological information calculation unit IC calculates the pulse wave propagation time Tt from the time difference between the second reference time point B2 and the first reference time point B1.

  For example, as shown in FIG. 14, the pulse wave propagation time Tt has a characteristic that it is shortened when the blood pressure of the living body is increased and is extended when the blood pressure value is decreased, and is correlated with the blood pressure of the living body. It is possible to measure (estimate) the blood pressure value by using it.

Then, the biological information calculation means IC calculates the blood pressure value BP _{t of the} living body using the following regression equation (1) based on the pulse wave propagation time. In the regression equation (1), K ₁ and K ₂ are constants.

  In order to increase the accuracy of the blood pressure value to be calculated, the pulse wave propagation time approaches the actual pulse wave propagation time in consideration of the delay time specific to the circuit constituting the pulse wave detection means PD and the delay time specific to the living body. You may make it correct | amend.

In this case, the corrected pulse wave propagation time Td is expressed by the following equation (2). In the following equation (2), T _C is a circuit specific delay time, T _B is a biological specific delay time. By using the corrected pulse wave propagation time Td as the pulse wave propagation time Tt in the regression equation (1), the accuracy of the calculated blood pressure value can be increased.

Td = T _t −Tc−T _B (2)

Here, for example, the biological information calculation means IC corrects the pulse wave propagation time by subtracting a predetermined delay time from the pulse wave propagation time. Note that the delay time is the sum of the circuit specific delay time T _C constituting the pulse wave detection means PD, a biological specific delay time T _B.

Then, the biological information calculation means IC calculates the blood pressure value BP _{t of the} living body using the regression equation (1) based on the corrected pulse wave propagation time Td.

  Next, an example of a control method for measuring biological information by the biological information measuring apparatus 100 having the above configuration will be described.

  First, the sensor wearing means C of the biological information measuring device 100 is worn on the living body, and the electrocardiogram detecting means ED and the pulse wave detecting means PD are arranged on the surface of the living body (for example, see FIGS. 4 and 5). Then, for example, the control unit CON of the biological information measuring apparatus 100 is activated and starts a control operation by a user operation input.

  Then, the activated control unit CON detects the electrocardiogram signal SE of the living body's electrocardiogram by the electrode X of the electrocardiogram detection means ED, and outputs the electrocardiogram signal SE detected by the electrode X.

  Furthermore, the control part CON detects the pulse wave signal SP of the pulse wave generated from the blood vessel in the living body by the pulse wave detection means PD, and outputs the detected pulse wave signal SP.

  Then, the control unit CON detects and amplifies the electrocardiogram signal SE and the pulse wave signal SP output from the electrocardiogram detection means ED and the pulse wave detection means PD by the signal detection means SD. Digitally convert and output.

  And the control part CON calculates the biological information of a biological body based on the electrocardiogram signal SE and the pulse wave signal SP after the digital conversion which the signal detection means SD output by the biological information calculation means IC.

  As described above, the control unit CON determines, for example, the first reference time point B1 determined in advance of the electrocardiogram of the electrocardiogram signal SE detected by the electrocardiogram detection unit ED by the biological information calculation unit IC ( FIG. 13).

  And the control part CON determines predetermined 2nd reference | standard time B2 of the pulse wave of the pulse-wave signal SP detected by the pulse-wave detection means PD by biometric information calculation means IC (FIG. 13).

  And the control part CON calculates the pulse wave propagation time Tt from the time difference of 2nd reference | standard time B2 with respect to 1st reference | standard time B1 by biometric information calculation means IC.

Then, the control unit CON calculates the blood pressure value BP _{t of the} living body using the regression equation (1) described above based on the pulse wave propagation time by the living body information calculating unit IC.

  Then, the control unit CON transmits the biological information calculated by the biological information calculation unit IC to the biological information output unit by the biological information transmission unit IT.

  And the control part CON outputs the biological information transmitted from the biological information transmission means IT to the outside by the biological information output means IO (displays on the display part Z).

Here, as described above, the electrode X made of the flexible conductive member of the electrocardiogram detection means ED can reduce its electrostatic capacity, so that the waveform of the cardiac radio wave becomes sharp and the first described above. The detection accuracy of the reference time point (for example, the peak of the R wave) can be improved.
That is, according to the biological information measuring apparatus 100 according to the present embodiment, biological information can be measured with higher accuracy by measuring the pulse wave propagation time with higher accuracy by reducing the dullness of the electrocardiographic waveform. .

(Second Embodiment)
In the above-described first embodiment, an example of a configuration in which the biological information calculation unit IC that calculates biological information is arranged in the unit U of the main body has been described.

  However, even if the biological information calculation means IC for calculating the biological information is not arranged in the unit U of the main body, even if the biological information calculation means IC is arranged outside the unit U, the same control operation is executed. Is possible.

  Therefore, in the second embodiment, an example in which the biological information calculation unit IC is arranged outside the unit U will be described.

  FIG. 15 is a block diagram illustrating an example of a configuration of the biological information measuring apparatus 100 according to the second embodiment. In FIG. 15, the same reference numerals as those in FIG. 1 indicate the same configurations as those in the first embodiment.

  As shown in FIG. 15, a biological information measuring apparatus 200 for noninvasively measuring biological information of a living body according to the second embodiment includes an electrocardiogram detecting means ED, a pulse wave detecting means PD, and a sensor. A wearing means C, a signal detecting means SD, a storage means M, a biological information output means IO, and a controller CON are provided.

  Here, the signal detection means SD detects and amplifies the electrocardiogram signal SE and the pulse wave signal SP output from the electrocardiogram detection means ED and the pulse wave detection means PD, and converts the amplified signal from analog to digital. Output.

  Then, the detection information transmission means IT outputs the signals output from the signal detection means SD (that is, information on the electrocardiogram signals SE and pulse wave signals SP detected by the electrocardiogram detection means ED and the pulse wave detection means PD) to the control unit CON. To be transmitted to.

  And the control part CON calculates and outputs the biological information of a biological body by the biological information calculation means IC based on the information of the electrocardiogram signal SE and the pulse wave signal SP.

  The biometric information output means IO outputs the biometric information calculated by the biometric information calculation means IC to the outside.

  Other configurations of the biological information measuring apparatus 200 according to the second embodiment are the same as those of the biological information measuring apparatus 100 according to the first embodiment.

  That is, as in the first embodiment, the biological information measuring apparatus 200 according to the second embodiment reduces the dullness of the electrocardiogram waveform and measures the pulse wave propagation time with higher accuracy, thereby improving the accuracy. Biological information can be measured well.

  Although several embodiments of the present invention have been described, these embodiments are presented by way of example and are not intended to limit the scope of the invention. These embodiments can be implemented in various other forms, and various omissions, replacements, and changes can be made without departing from the spirit of the invention. These embodiments and their modifications are included in the scope and gist of the invention, and are also included in the invention described in the claims and the equivalents thereof.

  The present invention is useful for obtaining an electrocardiographic waveform with less waveform dullness, particularly for a sphygmomanometer that estimates a blood pressure by obtaining a pulse wave propagation time from the waveform.

100, 200 Biological information measuring device ED Electrocardiograph detecting means PD Pulse wave detecting means C Sensor wearing means SD Signal detecting means M Storage means IO Biological information output means CON Control section

Claims (15)

A biological information measuring device for non-invasively measuring biological information of a living body,
An electrocardiograph detecting means for outputting an electrocardiogram signal detected by the electrode, comprising an electrode made of a flexible conductive member for detecting an electrocardiogram signal of the electrocardiogram of the living body;
A pulse wave detection means for detecting a pulse wave signal of a pulse wave generated from a blood vessel in the living body, and outputting the detected pulse wave signal;
At least in part, the electrode of the electrocardiogram detection means is provided, and a sensor wearing means for the living body to wear,
A control unit that controls the electrocardiogram detection unit and the pulse wave detection unit, the control unit including biometric information calculation unit that calculates biometric information of the living body based on the electrocardiogram signal and the pulse wave signal; Comprising
Biological information measuring device.   The flexible conductive member is a woven fabric, a knitted fabric or a non-woven fabric composed of a multifilament yarn made of a thermoplastic polymer having a single fiber diameter of 100 nm to 1000 nm, and the surface of the single fiber or the single fiber and the single fiber The biological information measuring device according to claim 1, wherein a conductive substance is contained in the gap.   The biological information measuring device according to claim 2, wherein a capacitance component of impedance of the electrode is in a range of 0.001 μF to 0.1 μF.   The biological information measuring device according to claim 3, wherein a capacitance component of a contact impedance between the electrode and the biological surface is in a range of 0.001 μF to 0.1 μF. While detecting and amplifying the electrocardiogram signal and the pulse wave signal, further comprising a signal detection means for outputting the amplified signal by analog-digital conversion,
The biological information measuring apparatus according to claim 2, wherein the biological information calculating unit calculates biological information of the living body based on the electrocardiogram signal and the pulse wave signal after digital conversion output from the signal detecting unit.   The storage unit stores a program for controlling the electrocardiogram detection unit and the pulse wave detection unit, and stores a calculation result of the biological information calculated by the biological information calculation unit. 5. The biological information measuring device according to 5.   The biological information measuring device according to any one of claims 1 to 6, wherein the biological information is a blood pressure value of the biological body. The pulse wave detecting means includes
A light emitting unit that irradiates light on the blood vessels of the living body, and a light detection unit that detects scattered light reflected or transmitted by the light irradiated on the blood vessels,
The pulse wave detection means
The biological information measuring device according to claim 7, wherein a pulse wave corresponding to a scattered light amount of the scattered light that has changed with a volume change of the blood vessel of the biological body is detected based on a relationship between the light and the scattered light.   The biological information measuring device according to claim 6, further comprising a biological information transmission unit that transmits the biological information calculated by the biological information calculation unit to the biological information output unit.   The biological information measuring device according to claim 6, further comprising detection information transmission means for transmitting information on the electrocardiogram signal and the pulse wave signal detected by the electrocardiogram detection means and the pulse wave detection means to the control unit. The biological information calculation means includes
Determining a predetermined first reference time point of the electrocardiogram of the electrocardiogram signal detected by the electrocardiogram detection means;
Determining a predetermined second reference time point of the pulse wave of the pulse wave signal detected by the pulse wave detection means;
A pulse wave propagation time Tt is calculated from a time difference between the second reference time and the first reference time,
The biological information measuring device according to claim 7, wherein the blood pressure value BP _{t of the} living body is calculated using the following formula (1) based on the pulse wave propagation time.
In the above formula (1), K ₁ and K ₂ are constants. The biological information calculation means includes
Correcting the pulse wave propagation time by subtracting a predetermined delay time from the pulse wave propagation time,
The biological information measuring device according to claim 11, wherein the blood pressure value BP _{t of the} living body is calculated using the formula (1) based on the corrected pulse wave propagation time.   The biological information measuring apparatus according to claim 12, wherein the delay time is a sum of a delay time specific to a circuit constituting the pulse wave detection unit and a delay time specific to the living body.   The biological information according to claim 11, wherein the biological information calculation means determines the second reference time point from a waveform obtained by first-order differentiation of the pulse wave signal detected by the pulse wave detection means with time. measuring device. An electrocardiogram detecting means having an electrode made of a flexible conductive member for detecting an electrocardiogram signal of an electrocardiogram of a living body and outputting the electrocardiogram signal detected by the electrode; and generated from a blood vessel in the living body A pulse wave detection means for detecting a pulse wave signal of the pulse wave to be output, and outputting the detected pulse wave signal; and at least a part of the electrode of the electrocardiogram detection means is provided for the living body to wear A control method for a biological information measuring device comprising sensor wearing means, and a controller for controlling the electrocardiogram detection means and the pulse wave detection means,
The electrocardiogram detection means detects an electrocardiogram signal detected by the electrode made of the flexible conductive member,
A pulse wave signal is detected by the pulse wave detection means,
Calculating biological information of the living body based on the electrocardiogram signal and the pulse wave signal by the biological information calculating means of the control unit;
Control method of biological information measuring device.