JP2016214563A - Biological information measuring apparatus - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a biological information measuring apparatus capable of assisting in accurately determining a cause of a change in biological information.SOLUTION: A blood pressure measuring apparatus 1 comprises: a pulse wave detection unit 10 for detecting a pulse wave per beat from a living body; a blood pressure measurement unit 11 for measuring a blood pressure value as biological information on the basis of the pulse wave detected by the pulse wave detection unit 10; a temperature sensor 12 for measuring air temperature, which is one information item relating to a cause of a change in the blood pressure value; and a recording control unit 13 for recording, in a recording medium 14, the blood pressure value generated by the blood pressure measurement unit 11 on the basis of the pulse wave per beat detected by the pulse wave detection unit 10, in association with the temperature information measured by the temperature sensor 12 at the detection timing of the pulse wave.SELECTED DRAWING: Figure 1

Description

  The present invention relates to a biological information measuring device.

  The blood pressure value of a living body usually has a relatively large daily variation. For this reason, for a diagnosis or the like, a blood pressure meter is attached to the measurement subject, and blood pressure values are measured and recorded regularly (for example, at intervals of several hours). In this case, in order to clarify the cause of the change in blood pressure value accurately and easily, the measurement of information related to the cause of the change in blood pressure value is performed together with the measurement of the blood pressure value and recorded ( (See Patent Documents 1 and 2).

  In Patent Document 2, information on an acceleration sensor attached to a living body and a blood pressure value are recorded in association with each other, and the correlation between the amount of exercise and a change in physiological function can be grasped in detail from the recorded information. An apparatus that can be used for the above is described.

  Patent Document 1 describes a device that continuously records a blood pressure value, exercise intensity, and temperature, and supports the elucidation of the cause of the change in blood pressure value from the recorded information.

  As a device suitable for continuously measuring blood pressure values, such as the devices described in Patent Documents 1 and 2, a pressure sensor is brought into direct contact with a biological site through which an artery such as the radial artery of the wrist passes. There is known a biological information measuring device capable of continuously measuring biological information such as a pulse and a blood pressure value (every beat) using information on a pressure pulse wave detected by this sensor in a state (patent) Reference 3-6).

Japanese Utility Model Publication No. 62-157504 Japanese Patent Laid-Open No. 04-161143 JP 2004-113368 A Japanese Patent Laid-Open No. 02-261421 Japanese Patent Laid-Open No. 07-124130 Japanese Patent Laid-Open No. 01-242031

  The devices described in Patent Documents 1 and 2 assume that blood pressure values are measured at long time intervals such as several minutes, several tens of minutes, or several hours. However, when the blood pressure value is measured at such a long time interval, when there is a large blood pressure change during a period when the blood pressure value is not measured, a doctor or the like cannot know the blood pressure change. Further, in comparison of blood pressure values measured at long time intervals, it is difficult to accurately know that the blood pressure change itself has occurred and its cause.

  According to the device that measures the blood pressure value for each beat like the devices described in Patent Documents 3 to 6, doctors and the like can accurately grasp the fine blood pressure changes caused by the daily life of the patient. Become.

  In order to know the cause of blood pressure change, it is important to accurately know the information related to the cause of the change in blood pressure value (for example, temperature) at the time when the blood pressure value has changed greatly and the time point before that time point. It is.

  Until now, there has been no known device that measures and records the blood pressure value measured for each beat and information related to the cause of the change in the blood pressure value. This is thought to be very useful for diagnosis support. Although the blood pressure value is taken as an example here, it is thought that the other biological information (for example, the pulse) is greatly useful for diagnosis support by a doctor if the cause of the change can be grasped in detail.

  The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a biological information measuring device that can support accurate grasp of the cause of changes in biological information.

  The biological information measuring device of the present invention includes a pulse wave detection unit that detects a pulse wave from a living body for each beat, a biological information measurement unit that measures biological information based on the pulse wave detected by the pulse wave detection unit, A living body information different from the living body information measured by the living body information measuring unit, environmental information of a place where the living body exists, and an information measuring unit that measures at least one of the living body activity information; Biological information generated by the biological information measuring unit based on the pulse wave for each beat or every plurality of beats detected by the pulse wave detecting unit, and information measured by the information measuring unit at the detection timing of the pulse wave And a recording control unit that records them in association with each other.

  ADVANTAGE OF THE INVENTION According to this invention, the biometric information measuring apparatus which can support the exact grasp of the change cause of biometric information can be provided.

It is a figure showing the schematic structure of blood pressure measuring device 1 as a living body information measuring device for explaining one embodiment of the present invention. It is a figure which shows an example of the pressure pulse wave detected by the pulse wave detection part of FIG. 1, and the air temperature detected by the temperature sensor. It is a figure for demonstrating the matching process of the blood pressure value and temperature information by the recording control part 13 of FIG. It is a figure for demonstrating the analysis process by the server which acquired data from the blood-pressure measuring apparatus 1 of FIG. It is a figure for demonstrating the modification of the matching process of the blood pressure value and temperature information by the recording control part 13 of FIG. It is a figure which shows an example of the format of the data recorded on the recording medium 14 by the recording control part 13 of FIG.

  Embodiments of the present invention will be described below with reference to the drawings.

  FIG. 1 is a diagram showing a schematic configuration of a blood pressure measurement device 1 as a biological information measurement device for explaining an embodiment of the present invention. This blood pressure measurement device 1 is a portable type, and is always used by being worn on a part of the body of a measurement subject (for example, a wrist) as a living body.

  The blood pressure measurement device 1 includes a pulse wave detection unit 10, a blood pressure measurement unit 11, a temperature sensor 12, a recording control unit 13, a recording medium 14, a communication unit 15, and a transmission control unit 16. The blood pressure measurement unit 11, the recording control unit 13, and the transmission control unit 16 are functional blocks that are expressed when the processor executes a program.

  The pulse wave detection unit 10 detects a pulse wave non-invasively from a living body. As the pulse wave detection unit 10, for example, a unit that detects a pressure pulse wave as a pulse wave by a tonometry method is used. The pulse wave detection unit 10 may detect a volume pulse wave as a pulse wave. The pulse wave detection unit 10 may detect a pulse wave by reflected light from an artery obtained by applying light to the artery. In the following description, it is assumed that the pulse wave detector 10 detects a pressure pulse wave by the tonometry method.

  The pulse wave detection unit 10 detects a pressure pulse wave for each beat, and transmits the detected pressure pulse wave to the blood pressure measurement unit 11. From the pulse wave detection unit 10, a continuous pressure pulse wave as illustrated in FIG. 2 is transmitted to the blood pressure measurement unit 11.

  The blood pressure measurement unit 11 measures the blood pressure value for each beat of the living body based on the pressure pulse wave for each beat detected by the pulse wave detection unit 10. As a method for measuring the blood pressure value, a known method as described in Patent Documents 3 to 6 can be used. The blood pressure measurement unit 11 associates the rise time information (pressure pulse wave detection time information) of the pressure pulse wave indicating the detection timing of an arbitrary pressure pulse wave with the blood pressure value measured based on the pressure pulse wave. , To the recording control unit 13.

  The temperature sensor 12 detects and holds the temperature (air temperature) of the place where the living body exists at a predetermined sampling period, and holds the held temperature information and time information (temperature holding time information) holding the temperature information. This is transmitted to the recording control unit 13.

  The recording control unit 13 temporarily stores in the internal memory a set of pressure pulse wave detection time information and blood pressure value transmitted from the blood pressure measurement unit 11 and a set of temperature holding time information and temperature information transmitted from the temperature sensor 12. To do.

  The recording control unit 13 reads out the temperature information corresponding to the time closest to each pressure pulse wave detection time information stored in the internal memory among the temperature information stored in the internal memory, and reads the read temperature information and the pressure pulses. The blood pressure value corresponding to the wave detection time information is associated and recorded on the recording medium 14.

  FIG. 3 is a diagram for explaining a process of associating a blood pressure value with temperature information by the recording control unit 13.

  As shown in FIG. 3, blood pressure values (outlined blocks in the figure) and temperature information (hatched blocks in the figure) are stored in the internal memory of the recording control unit 13 in association with the time.

  The recording control unit 13 specifies temperature information corresponding to the time closest to the time corresponding to each blood pressure value, and records each blood pressure value and the specified temperature information in the recording medium 14 in association with each other. In the example of FIG. 3, the blood pressure value and temperature information connected by the broken-line arrows are recorded in association with each other.

  In the example of FIG. 3, the time corresponding to each of the blood pressure value and the temperature information connected by the broken-line arrow completely matches, but the two times may not match, so the recording control unit 13 The temperature information corresponding to the time closest to the time corresponding to is specified. If there are two times closest to the time corresponding to the blood pressure value, one of the two times may be selected.

  The time corresponding to the blood pressure value is the rise time of the pressure pulse wave used for the measurement of the blood pressure value. For this reason, the relationship between the pressure pulse wave and the temperature information (air temperature) is as shown in FIG. As shown in FIG. 2, as the amplitude of the pressure pulse wave increases, the blood pressure value also increases. It can be seen that the temperature decreases as the blood pressure value increases. That is, by looking at the transition of the blood pressure value and the temperature information recorded in the recording medium 14, it becomes possible for a doctor or the like to grasp that the cause of the change in the blood pressure value is due to the temperature.

  The communication unit 15 is an interface for performing communication with an external device by wire or wireless.

  The transmission control unit 16 transmits the data recorded on the recording medium 14 to the external device via the communication unit 15.

  The external device here is, for example, a server connected to a network. This server is managed by a hospital, for example. In this server, the blood pressure value and temperature information data are received from the blood pressure measurement device 1, the received data is analyzed, and the analysis result is displayed on the display unit.

  When the blood pressure measurement device 1 configured as described above is attached to the measurement subject and turned on, the pulse wave detector 10 starts detecting the pressure pulse wave, and the temperature sensor 12 starts detecting the temperature. Is done. When the pressure pulse wave is detected, the blood pressure measurement unit 11 measures the blood pressure value, and the blood pressure value and the time information of the detection timing of the pressure pulse wave used to measure the blood pressure value are stored in the recording control unit 13. Recorded in internal memory. When the temperature information is detected, the detected temperature information and time information indicating the detection time are recorded in the internal memory of the recording control unit 13.

  Each time a certain number of blood pressure values and temperature information are recorded, the recording control unit 13 specifies blood pressure values and temperature information corresponding to substantially the same time information as described with reference to FIG. A process of associating the value with the temperature information and recording it on the recording medium 14 is performed.

  The person to be measured uses the blood pressure measurement device 1 for a certain period (for example, one day), then goes to the hospital, operates an operation button (not shown), and stores the blood pressure value and temperature information recorded in the recording medium 14 at the hospital management terminal. (Server) to send.

  For example, when the blood pressure value and temperature information for one day are acquired, the management terminal calculates a difference between adjacent blood pressure values for blood pressure values arranged in time series.

  FIG. 4 is a diagram for explaining an example of analysis processing by the management terminal.

  In the upper part of FIG. 4, blood pressure values acquired from the blood pressure measurement device 1 are shown in time series. The white rectangle shown in FIG. 4 indicates the blood pressure value, and the longer the rectangle is, the larger the blood pressure value is.

  The middle part of FIG. 4 shows the result of taking a difference between adjacent blood pressure values in the upper part. In the middle part of FIG. 4, the difference value between the blood pressure value corresponding to an arbitrary time and the blood pressure value corresponding to the next time of this time is recorded as a difference value corresponding to this arbitrary time.

  In the lower part of FIG. 4, temperature information acquired from the blood pressure measurement device 1 is shown in time series. A rectangle with hatched hatching shown in FIG. 4 indicates temperature information, and the longer the length of the rectangle, the larger the temperature information.

  After obtaining the difference value shown in the middle part of FIG. 4, the management terminal identifies a period (a period indicated by a bidirectional arrow in the figure, a period in which the blood pressure change is large) corresponding to the difference value equal to or greater than the threshold value. The difference between the temperature information corresponding to the beginning and the temperature information corresponding to the end of this period is calculated.

  If the difference in the temperature information is equal to or greater than the threshold, the management terminal causes the display unit to display information indicating that the blood pressure value tends to change greatly due to a change in temperature as an analysis result. Based on the analysis result, the doctor can grasp the blood pressure change tendency of the measurement subject and can make use of the treatment policy.

  As described above, according to the blood pressure measurement device 1, the blood pressure value measured for each beat and the temperature information detected at the timing when the blood pressure value is measured are associated with each other and recorded on the recording medium 14. . For this reason, by using the data recorded on the recording medium 14, it is possible to support accurate grasp of the cause of the change in blood pressure value.

  In the blood pressure measurement device 1, only the temperature information measured at the detection timing of the pressure pulse wave is recorded on the recording medium 14. For this reason, compared with the case where all the temperature information sampled and hold | maintained by the temperature sensor 12 is recorded on the recording medium 14, the capacity | capacitance of the recording medium 14 can be small, and the cost of an apparatus can be reduced.

  Moreover, when the form which regularly transfers the data which the blood pressure measurement apparatus 1 recorded on the recording medium 14 to a server is assumed, the data amount transmitted to the server from the blood pressure measurement apparatus 1 can be reduced. For this reason, power consumption for data transmission can be reduced. On the server side, data can be acquired in a state where the blood pressure value and the temperature information are associated with each other. For this reason, it is not necessary to extract temperature information corresponding to the detection timing of the pressure pulse wave used for measuring the blood pressure value from a large number of temperature information, and the server load can be reduced.

  Considering that the server receives data from a large number of blood pressure measurement devices 1 and performs analysis, it is preferable that the processing load on the server is small. By using the blood pressure measurement device 1, the server only needs to perform the simple processing described with reference to FIG. 4, thereby reducing the processing load. Therefore, it is not necessary to prepare a server with high processing capacity, and the cost for system construction can be reduced.

  In the above description, the recording control unit 13 records temperature information in association with the blood pressure value for each beat measured by the blood pressure measurement unit 11. As a modified example, the recording control unit 13 may record the temperature information in association with the blood pressure value for each of a plurality of beats measured by the blood pressure measurement unit 11.

  Specifically, as shown in FIG. 5, the blood pressure value is recorded in the internal memory as a value measured for each beat, but the recording control unit 13 selects 2 of the blood pressure values recorded in the internal memory. Only the blood pressure value measured for each beat (the first, third, fifth, and seventh blood pressure values from the left in FIG. 5) is the most suitable for the detection timing of the pressure pulse wave used to measure this blood pressure value. The temperature information detected at a close time is associated and recorded on the recording medium 14.

  According to this modification, the amount of data recorded on the recording medium 14 can be reduced, so that it is possible to reduce the device manufacturing cost by reducing the capacity of the recording medium 14 and to reduce power consumption by reducing the amount of data transmission.

  Even if the amount of data recorded on the recording medium 14 is reduced as in the modification, the amount of change between the blood pressure value at a certain time and the blood pressure value after two beats at this time, and the temperature at these two times It is possible to know the relationship with the amount of change in information. For this reason, the effect that the cause of blood pressure change of the measurement subject can be surely grasped can be obtained.

  In this modified example, the measured blood pressure value is thinned out and recorded, but if the number of blood pressure values to be thinned is too large, it becomes difficult to grasp the cause of blood pressure change of the measurement subject. For this reason, in this modified example, it is preferable to set one blood pressure value to the recording medium 14 every 2 to 10 beats.

  In the blood pressure measurement device 1 shown in FIG. 1, temperature information is taken as an example of information recorded on the recording medium 14 in association with the blood pressure value. Instead of this temperature information, the humidity information of the environment where the blood pressure measurement device 1 is placed may be recorded on the recording medium 14. The temperature information and the humidity information constitute environmental information of the place where the measurement subject exists.

  Further, instead of temperature information, the blood pressure measurement unit 11 measures the blood oxygen saturation of the subject, the state of the subject's autonomic nerve, the stress level of the subject, and the body temperature of the subject. It is good also as a structure which records the to-be-measured person's biometric information different from the biometric information to the recording medium 14. FIG. According to this configuration, for example, when the blood pressure value fluctuates greatly, it is possible to grasp how the biological information of the measurement subject has changed, which can be used for diagnosis.

  Also, instead of temperature information, the exercise intensity of the subject, information on whether the subject is eating, information indicating that the living body has started eating, information indicating that the living body has finished eating The activity information of the measurement subject such as the depth of sleep of the measurement subject, the elapsed time from the sleep of the measurement subject, and the posture of the measurement subject may be recorded on the recording medium 14. According to this configuration, for example, when the blood pressure value greatly fluctuates, it is possible to grasp what the activity state of the measurement subject is, so that it can be used for diagnosis.

  The state of the subject's autonomic nerve (information such as which sympathetic nerve or parasympathetic nerve is dominant) and the stress level can be obtained according to the measured heart rate by measuring the heart rate of the subject.

  The exercise intensity of the subject can be obtained by measuring the oxygen intake of the subject and measuring the ratio of the measured oxygen intake and the maximum oxygen intake of the subject. It is also possible to measure the heart rate of the person to be measured and obtain it by the ratio of the measured heart rate and the maximum heart rate of the person to be measured. Further, an acceleration sensor can be mounted on the blood pressure measurement device 1, and it can be obtained by a known method based on information on the movement of the measurement subject detected by the acceleration sensor.

  Information on whether or not the measured person is eating indicates that the measured person is eating during the period from the start of the meal to the end of the meal, for example, by performing a button operation when the measured person starts and ends the meal. Information can be generated and recorded. Alternatively, by receiving a signal indicating that the meal has been started by receiving a signal indicating that the meal has been started (a signal indicating that the meal has started and a signal indicating that the meal has ended) from the outside, the meal has ended. Until receiving a signal indicating that, information indicating that a meal is in progress may be recorded.

  Information indicating that the measurement subject has started the meal and information indicating that the meal has ended can be acquired by the above button operation, respectively. Or it can also acquire by receiving the signal which shows that the meal started, and the signal which shows that the meal was complete | finished from an external device.

  Information on the depth of sleep of the measurement subject and the elapsed time since falling asleep can be obtained by a technique used in a well-known sleep meter.

  The information on the posture of the measurement subject is information indicating whether the posture is a sitting position, a standing position, or a lying position, and can be obtained by a known method by combining an acceleration sensor, an atmospheric pressure sensor, or the like.

  Blood pressure values can change significantly when the subject moves from a warm place to a cold place, or when the subject is performing a heavy exercise (for example, muscle training, running, climbing stairs) When the measurer eats a meal that increases blood pressure, when the subject feels stress, when the subject's autonomic nerve is disturbed, when the subject enters an apnea state during sleep, And so on.

  Whether or not the measurement subject has moved from a warm place to a cold place can be grasped by the temperature information detected by the temperature sensor 12. Therefore, it can be said that the temperature information is information related to the cause of the change in blood pressure value.

  Whether or not the subject is exercising with a load can be determined by the exercise intensity. Therefore, it can be said that the exercise intensity is information related to the cause of the change in blood pressure value.

  Whether or not the subject has eaten can be grasped by measuring the body temperature because the body temperature rises by eating. Therefore, the body temperature can be said to be information related to the cause of the change in blood pressure value.

  Whether or not the measurement subject is in an apnea state at the time of sleep can be grasped by measuring the blood oxygen saturation. Therefore, it can be said that the blood oxygen saturation is information related to the cause of the change in blood pressure value.

  The blood pressure measurement device 1 is different from those measured by the blood pressure measurement unit 11 serving as a biological information measurement unit, the biological information of the measured person, the environmental information of the place where the measured person exists, and the activity information of the measured person. What is necessary is just to have the information measurement part which measures at least one.

  As the information measuring unit, in addition to the temperature sensor 12 shown in FIG. 1, a humidity sensor, a sensor for measuring blood oxygen saturation, a measuring unit for measuring an autonomic nerve state and a stress level using a heart rate sensor, and measuring body temperature. Specific examples include a sensor, a measurement unit that measures exercise intensity, a sleep meter, and a body posture measurement unit that measures body posture using an acceleration sensor.

  When using a sensor that measures biological information, such as a sensor that measures blood oxygen saturation or a sensor that measures body temperature, as the information measuring unit, the time when measurement of biological information of interest is started by this sensor, and There may be a deviation from the time when the biological information is stored as measurement information. For this reason, the recording control unit 13 correlates the blood pressure value with the biological information after correcting the shift uniformly for the time information corresponding to the biological information stored in the internal memory.

  Up to this point, the blood pressure measurement unit 11 is taken as an example of the biological information measurement unit, but the biological information measured by the biological information measurement unit is not limited to the blood pressure value. For example, the blood pressure measurement unit 11 of the blood pressure measurement device 1 may measure, for example, a pulse instead of a blood pressure value as biological information.

FIG. 6 is a diagram illustrating an example of a format of data recorded on the recording medium 14 by the recording control unit 13. In this example, blood pressure value (maximum blood pressure SYS, minimum blood pressure DIA), temperature, humidity, blood oxygen saturation (SPO ₂ ), stress state (1 with stress, 0 without stress), meal It is data in which information indicating whether or not it is inside (0 during non-meal, 1 during meal) and body position are recorded in association with each measurement time. Instead of the information on whether or not the meal is in progress, information indicating whether or not the meal has started (1 for the start of the meal, 0 except for the start timing of the meal), and information indicating whether or not the meal has ended (the end of the meal is 1, Other than the meal end timing, 0) may be used.

  It should be thought that embodiment disclosed this time is an illustration and restrictive at no points. The scope of the present invention is defined by the terms of the claims, rather than the description above, and is intended to include any modifications within the scope and meaning equivalent to the terms of the claims.

  As described above, the following items are disclosed in this specification.

  The disclosed biological information measuring device includes a pulse wave detection unit that detects a pulse wave from a living body for each beat, a biological information measurement unit that measures biological information based on the pulse wave detected by the pulse wave detection unit, A living body information different from the living body information measured by the living body information measuring unit, environmental information of a place where the living body exists, and an information measuring unit that measures at least one of the living body activity information; Biological information generated by the biological information measuring unit based on the pulse wave for each beat or every plurality of beats detected by the pulse wave detecting unit, and information measured by the information measuring unit at the detection timing of the pulse wave And a recording control unit that records them in association with each other.

  In the disclosed biological information measuring apparatus, the biological information includes at least one of a state of the autonomic nerve of the living body, a stress level of the living body, a blood oxygen saturation level of the living body, and a body temperature of the living body.

  In the disclosed biological information measuring apparatus, the environmental information includes at least one of temperature and humidity of a place where the living body exists.

  In the disclosed biological information measuring apparatus, the activity information includes exercise intensity of the living body, information on whether the living body is eating, information indicating whether the living body has started eating, or the living body is eating It includes at least one of information indicating whether or not it has been completed, the depth of sleep of the living body, the elapsed time from falling asleep of the living body, and the body position of the living body.

  In the disclosed biological information measurement device, the pulse wave detection unit detects a pressure pulse wave from the living body, and the biological information measurement unit measures a blood pressure value based on the pressure pulse wave.

  The present invention is particularly convenient and effective when applied to a portable blood pressure monitor.

DESCRIPTION OF SYMBOLS 1 Blood pressure measuring device 10 Pulse wave detection part 11 Blood pressure measurement part 12 Temperature sensor 13 Recording control part 14 Recording medium 15 Communication part 16 Transmission control part

Claims (5)

A pulse wave detector for detecting a pulse wave from a living body for each beat;
A biological information measuring unit that measures biological information based on the pulse wave detected by the pulse wave detecting unit;
An information measuring unit that measures at least one of the biological information of the living body different from the biological information measured by the biological information measuring unit, the environmental information of the place where the living body exists, and the activity information of the living body;
The biological information generated by the biological information measuring unit based on the pulse wave for each beat or every plurality of beats detected by the pulse wave detecting unit, and measured by the information measuring unit at the detection timing of the pulse wave A biological information measuring device comprising: a recording control unit that records information in association with each other. The biological information measuring device according to claim 1,
The biological information measuring device includes at least one of blood oxygen saturation of the living body, an autonomic state of the living body, a stress level of the living body, and a body temperature of the living body. The biological information measuring device according to claim 1,
The environmental information is a biological information measuring device including at least one of temperature and humidity of a place where the living body exists. The biological information measuring device according to claim 1,
The activity information includes exercise intensity of the living body, information on whether the living body is eating, information indicating whether the living body has started eating, information indicating whether the living body has finished eating, A biological information measuring device including at least one of a depth of sleep of the living body, an elapsed time from falling asleep of the living body, and a posture of the living body. The biological information measuring device according to any one of claims 1 to 4,
The pulse wave detection unit detects a pressure pulse wave from the living body,
The biological information measuring unit is a biological information measuring device that measures a blood pressure value based on the pressure pulse wave.

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