JP2016010728A - Ophthalmology information processing system, ophthalmology information processing method and program - Google Patents

Abstract

PROBLEM TO BE SOLVED: To achieve efficiency of C/D ratio drawing during follow-up.SOLUTION: An ophthalmology information processing system comprises: calculation means for acquiring a correction value for positioning a first ophthalmologic image and a second ophthalmologic image which are imaged at different imaging times and which image the same imaging object; positioning means for, using the correction value, positioning drawing information of a disk line of the second ophthalmologic image, drawing information of a cup line of the second ophthalmologic image, and the first ophthalmologic image; display means for displaying, on the first ophthalmologic image, the drawing information of the disk line of the second ophthalmologic image and drawing information of the cup line of the second ophthalmologic image which has been subjected to positioning with the first ophthalmologic image by drawing; and reception means for receiving a designation input of a disk line and cup line of the first ophthalmologic image on a screen on which, the first ophthalmologic image to which the drawing information of the disk line of the second ophthalmologic image and drawing information of the cup line of the second ophthalmologic image displayed by the display means are superposed, is displayed.

Description

  The present invention relates to a technique for detecting and analyzing an optic papilla from a fundus image.

  Glaucoma is one of the visual impairments. Conventionally, a C / D ratio that reflects the depressed state of the optic nerve head has been widely used as an index for diagnosis in glaucoma examination. The C / D ratio obtained using the fundus image is determined by the ratio of the respective diameters and the area ratio from the outer edge of the nipple (D) called the disc of the optic nerve head (hereinafter referred to as the nipple) and the outer edge of the nipple concave called the cup (C). Defined in Note that the diameter ratio in the vertical direction may be referred to as the vertical C / D ratio, and the diameter ratio in the horizontal direction may be referred to as the horizontal C / D ratio. In particular, since there are many changes in the vertical direction of the cup, the C / D ratio in the vertical direction is often used as an index.

  In recent years, the R / D ratio has also been used for glaucoma diagnosis. The R / D ratio is defined as the ratio between the width (R) of the rim region sandwiched between the outer edge of the nipple and the outer edge of the nipple recess and the measurement position of this width and the nipple outer edge diameter passing through the nipple center. In recent years, various methods for analyzing a fundus image and obtaining a C / D ratio and an R / D ratio have been developed (see Patent Documents 1 and 2). Further, the drawing information of the disc line, the cup line, and the rim line drawn on the fundus image for obtaining the C / D ratio and R / D ratio is recorded as annotation information of the fundus image, and past drawing is performed at the time of follow-up observation. A technique for visually displaying a difference from information has also been developed (see Patent Document 3). In the field of ophthalmology, a system for inputting a finding of a doctor or the like with reference to an ophthalmic image is also used (see Patent Document 4).

JP 2006-280411 A JP 2008-155491 A JP 2009-22506 A JP 2009-106532 A

  However, drawing analysis of disk lines and cup lines drawn on the fundus image is usually operated by an operator (for example, a doctor), and thus sufficient experience is required to draw an accurate line. In particular, in the follow-up observation, a measurement error occurs unless a line is drawn at the same position every time at a portion where there is no change, and the follow-up observation with an accurate C / D ratio is not possible. There are also systems that automatically extract the nipple from the fundus image and draw disc lines and cup lines, but it is difficult to recognize the exact line, and the operator often corrects the drawn line. , Operator experience is required.

  The object of the present invention is to solve the above-mentioned problems and assist the operator's work so that the drawing can be performed at the same position as the previous drawing when performing the follow-up observation of the change in the C / D ratio. To provide an ophthalmologic information processing system and program capable of reducing an error in a C / D ratio change amount.

  The ophthalmologic information processing system of the present invention includes a storage means for storing a first ophthalmic image and a second ophthalmic image obtained by photographing the same subject at different times, the first ophthalmic image, and the second ophthalmic image. Calculation means for obtaining a correction value for aligning the ophthalmic image, and using the correction value, the drawing information of the disk line of the second ophthalmic image and the drawing information of the cupline of the second ophthalmic image; Positioning means for aligning with the first ophthalmic image, and a discline of the second ophthalmic image on the first ophthalmic image that has been aligned with the first ophthalmic image. Display means for drawing and displaying drawing information and drawing information of the cup line of the second ophthalmic image, and drawing information and second ophthalmology of the disk line of the second ophthalmic image displayed by the display means Image Receiving means for accepting a designation input of a discline of the first ophthalmic image and a cupline of the first ophthalmic image to a screen on which the first ophthalmic image on which the drawing information is superimposed is displayed. It is characterized by that.

  According to the present invention, it is possible to reduce measurement errors during follow-up by drawing while checking whether the line information of the C / D ratio drawn in the ophthalmic image at the time of follow-up is at the same position each time. Is possible.

It is a figure which shows the functional structure of the ophthalmic information processing system which concerns on embodiment of this invention. It is a figure which shows the hardware constitutions of the ophthalmologic information processing system which concerns on embodiment of this invention. It is a flowchart figure which shows the process of the ophthalmic information processing system which concerns on embodiment of this invention. It is a figure which shows the data of the selection image. It is a figure which shows the data of the result of having searched the data in a database. It is a figure which shows the screen which performs C / D ratio drawing. It is a figure which shows the screen which performs C / D ratio drawing. It is a figure which shows the screen which performs C / D ratio drawing. It is a figure which shows the screen which performs C / D ratio drawing. It is a figure which shows the screen which performs C / D ratio drawing. It is a figure which shows the comparison screen of C / D ratio drawing.

  DESCRIPTION OF EXEMPLARY EMBODIMENTS Hereinafter, preferred embodiments to which the invention is applied will be described in detail with reference to the accompanying drawings.

  FIG. 1 is a diagram showing a functional configuration of an ophthalmologic information processing system according to an embodiment of the present invention. The ophthalmologic information processing system according to the present embodiment includes a computer used by an operator. The computer is connected to a database that stores and manages ophthalmic images, patient information, and the like via a communication line such as a LAN (Local Area Network). The ophthalmologic information processing system may be configured by a single computer, or an ophthalmic image or the like may be stored in an external storage device such as a CD (Compact Disc). Further, the ophthalmologic information processing system may be connected to the ophthalmologic photographing apparatus via a communication line. Examples of the ophthalmologic photographing apparatus include a fundus camera, OCT (Optical Coherence Tomography), SLO (Scanning Laser Ophthalmoscope), and the like.

  As shown in FIG. 1, the ophthalmologic information processing system includes an operation unit 1, a display unit 2, a control unit 3, a storage unit 4, a C / D ratio input unit 13, an alignment unit 10, a data input unit 9, a change amount. A calculation unit (not shown) is provided. First, the storage unit 4 will be described. The storage unit 4 stores an ophthalmic image 5, drawing information 6, and identification information 7. The ophthalmologic image 5 is an image of an imaging target (eye to be examined) acquired by the above ophthalmologic imaging apparatus. Examples include a fundus image taken by a fundus camera, a tomographic image of the fundus taken by OCT, a retina or choroid image taken by SLO, and the like. The ophthalmologic image 5 is stored with additional information such as a part of the eye to be examined, imaging date and time, imaging conditions, and the like. The part of the eye to be examined includes left and right eye information and information such as the nipple and macula. Further, the photographing conditions include information such as a photographing field angle, an imaging magnification, illumination light brightness, and a fixation lamp position. The drawing information 6 is C / D ratio information created by the C / D ratio input unit 13 and is stored in the storage unit 4 by the control unit 3.

  The identification information 7 is information for identifying each eye to be examined. For example, patient identification information such as patient name or patient ID is associated with individual ophthalmic images, or individual ophthalmic images and individual drawing information are associated with each other. As a result, it is possible to identify which part of which patient is the ophthalmic image and which is the C / D ratio drawing information of the ophthalmic image. The association process is executed by the control unit 3.

  The operation unit 1 is used when the operator operates the ophthalmologic information processing system or inputs C / D ratio information. When the operation unit 1 receives an operation by the operator, the operation unit 1 generates an operation signal according to the operation content and inputs the operation signal to the control unit 3. The operation unit 1 includes an arbitrary operation device and input device such as a keyboard, a mouse, a trackball, and a touch panel.

  The display unit 2 displays a screen and data according to the control unit 3. The display unit 2 includes an arbitrary display device such as an LCD (Liquid Crystal Display) or a CRT (Cathode Ray Tube) display. It is also possible to use a device in which an operation unit such as a touch panel described in the operation unit 1 and a display unit are integrated. In this case, the operation unit and the display unit shown in FIG. 1 are integrated.

  The control unit 3 controls each unit of the ophthalmologic information processing system. The control will be described later. The C / D ratio input unit 13 operates when inputting information on the C / D ratio. The information of the C / D ratio is position information of a disk outer periphery line (disk line) and a cup outer periphery line (cup line). In order to input the C / D ratio, an ophthalmic image is displayed on the display unit 2 and is operated by the operation of the operation unit 1 to process which position of the ophthalmic image the C / D ratio information is input, and the result is displayed. Remember. C / D ratio information discline and cupline are determined by the operator's method of inputting and specifying the discline, and the nipple of the ophthalmic image is automatically extracted, and the discline and cupline are extracted and drawn. There is a way to do it.

  The alignment unit 10 calculates, as a correction value, alignment information obtained by performing alignment processing between the ophthalmic image and the ophthalmic image to be aligned, and performs processing for aligning the position of the C / D ratio information based on the alignment information. The change amount calculation unit calculates the change amount of the C / D ratio. For example, the difference amount between the C / D ratio information and the C / D ratio information stored in the drawing information 6 of the storage unit 4 is calculated. Alternatively, the shortest distance between the C / D ratio information and a certain point is calculated.

  FIG. 2 shows an example of the hardware configuration of the ophthalmologic information processing system. The ophthalmologic information processing system includes a computer 20. The database 30 includes a server that stores and manages ophthalmologic images, patient information, and the like. The computer 20 is connected to the database 30 via a communication line such as a LAN.

  The operator inputs a request for viewing an ophthalmic image to the computer 20. This request is made, for example, by inputting or selecting patient identification information such as a patient name or patient ID and performing a predetermined operation (keyboard input key, mouse click, etc.). The computer 20 transmits the input request to the database 30. Based on this request, the database 30 searches for an ophthalmic image and transmits it to the computer 20. The computer 20 displays this search result.

  The computer 20 functions as, for example, the operation unit 1, the display unit 2, the control unit 3, the C / D ratio input unit 13, the alignment unit 10, and the change amount calculation unit in FIG. The database 30 functions as the storage unit 4. Similar to the configuration of a general computer, the computer 20 includes a CPU 21 as arithmetic processing, a RAM 22 that functions as a main storage device, a ROM 23 that functions as an external storage device, and an HDD (hard disk drive) 24 as an external storage device. A display 26, a keyboard 27, a mouse 28, and a communication I / F 29 are included. The computer 20 executes the operation of this embodiment by expanding the program 25 stored in the HDD 24 on the RAM 22.

  FIG. 3 shows a flowchart of C / D ratio drawing in the present embodiment. In this flowchart, an ophthalmologic image 5 will be described as an embodiment with a fundus image taken by a fundus camera, a display device of the display unit 2 as a display, a mouse and a keyboard as the operation unit 1 as an example.

  First, in step S1, the operator designates a fundus image for drawing a C / D ratio by operating the mouse. This operation is executed by, for example, clicking an image from the thumbnail image display of the fundus image and selecting the image. When the selection is executed, the control unit 3 reads information on the selected image and reads patient information associated with the image. The data including the patient information associated with the read selected image data is data 1 (first ophthalmic examination data 9A). An example of data is shown in FIG. From patient information to patient ID, from selected image information, examination UID, left and right eyes, part, image UID, imaging date, imaging time, C / D ratio data UID. The C / D ratio data UID is associated with C / D ratio drawing information (position information associated with the selected image), which is C / D ratio data, and information storing the measurement result of the C / D ratio. It has been. Such information can be acquired from the C / D ratio data UID. When the C / D ratio data does not exist, a value that does not indicate the presence of data (for example, NULL) is input. The drawing information of the C / D ratio is expressed as a set of certain coordinate points on the selected image.

  Next, in step S2, it is confirmed whether or not the previous C / D ratio exists. Taking the data in FIG. 4 as an example, if the patient ID of data 1 is “3”, the left and right eyes are “L”, the region is “papillae”, and the C / D ratio data UID exists, Search for the correct data from 4. An example of the search result is shown in FIG. When there are a plurality of C / D ratio data, the latest C / D ratio data is acquired. Taking FIG. 5 as an example, the image UID 257 is selected and S3 is executed. At this time, the image may be selected by displaying a list of the data shown in FIG.

  In step S3, the selected image is read. Data including the read image data and the C / D ratio data associated therewith is referred to as data 2 (second ophthalmic examination data 9B). Next, in step S4, alignment processing is performed on the fundus image of data 1 and the fundus image of data 2. In the alignment processing, image alignment processing of the alignment unit is performed. In this alignment process, first, the nipple is automatically extracted from the fundus image, the difference is calculated as a correction value, and the nipple is aligned based on this correction value. In particular, it is preferable to align the positions so that the centers of the nipples are best aligned. That is, it has a nipple extraction means for extracting a nipple area from the fundus image, and performs alignment so that the center of the optic nerve head is best aligned using the nipple area extracted by this extraction means.

  You may process so that the image position of the data 2 corresponding to the center position of the disk line of the drawing information of the C / D ratio of the data 2 may best match. Further, the positioning may be performed by extracting blood vessels. In this case as well, it is preferable to align the blood vessels near the nipple.

  Note that when the angle of view is different, the alignment processing is performed by performing enlargement and reduction processing. From the alignment process, a coordinate movement amount, a rotation angle, and an enlarged value are calculated as alignment information. In step S5, it is determined whether or not to perform alignment based on the correction value (alignment information) calculated in step S4. In the determination, when the alignment matching rate (correlation value after alignment) is low to some extent, it is determined that the alignment does not match and the alignment is not performed. In the case of determination of misalignment, the process may be advanced to step S7 without performing the alignment, or the search result may be displayed and the operator may select the previous C / D ratio data. Good. For example, the data shown in FIG. 5 is displayed on the display, and the operator selects the data by operating the mouse. When selected, the process returns to step S3 again.

  When the alignment is performed, the process proceeds to step S6. Based on the correction value obtained in step S4 and the drawing position information of the C / D ratio data of data 2, the C / D ratio of data 2 is drawn on the fundus image of data 1 and the drawing information is displayed on the display. FIG. 6 shows an example of the screen when the process of step S6 is completed. FIG. 6 is an example of a screen for inputting the C / D ratio. On the screen, the fundus image 41 selected in step S1 is displayed, and the operator selects an item to be rendered as an annotation from the annotation list. In order to draw the C / D ratio, the C / D ratio is selected from the annotation list 42 by clicking the mouse. The teat for measuring the C / D ratio is 43. 6 may be displayed after the process of step S1 is completed, and when the C / D ratio is selected from the annotation list 42, the process of step S2 may be performed.

  FIG. 7 shows a screen example after step S6. The disk line of data 2 is indicated by 51. The data 2 cupline is shown at 52. At this time, the drawing line of the C / D ratio of the data 2 is displayed lightly so that it can be distinguished from the drawing of the C / D ratio of the data 1 to be drawn. The line of data 2 may be displayed with a broken line. Alternatively, the data 2 line may be displayed in a different color from the C / D ratio drawing of data 1. In this embodiment, the C / D ratio drawing line of data 2 is displayed by a broken line.

  Next, in step S7, a disk line is drawn on the image of data 1 by a mouse operation or the like. First, the drawing of the disk line having the C / D ratio of the data 2 drawn on the image of the data 1 is reflected as the disk line of the data 1. At the start of drawing the disk line, it may be confirmed with the operator whether the disk line of the data 2 is reflected.

  Here, a case where a new disc line is drawn will be described. The drawing of the disc line is designated by clicking the point to be drawn on the image of data 1 displayed on the display while the operator operates the mouse, and the disc line is drawn. Specify multiple points on the outer edge of the disk line, and connect the specified points to a smooth line with a spline curve. If you want to edit a drawn point, select the point you want to edit with the mouse and move the point by moving the mouse, or add or delete the point. Alternatively, the drawing of the disc line may be performed by automatically recognizing the outer edge of the disc and automatically specifying the point along the recognized outer edge. The editing method in this case is the same as the method described above. When the editing is completed, the operator selects completion of drawing the disc line and confirms the disc line. For example, the editing is ended by double-clicking. Alternatively, it may be ended by causing the operator to operate an editing end button on the screen. When the disk line of data 2 is reflected in the drawing of the disk line, the same number of points as the specified number of points of data 2 are drawn. If you want to edit the discline, edit it as described above.

  In general, since the change in the outer edge of the disk is often small, the disk line may be automatically reflected, and the process may proceed to step S8 without editing the disk line. In this case, the disk line is edited if necessary after drawing the cup line. Next, in step S8, a cup line is drawn. The cup line is drawn in the same manner as the disc line. However, in the case of follow-up to check the progress and treatment of glaucoma, the change in the cup line is often large, so when selecting the drawing of the cup line, it will be possible to edit it reflecting the previous cup line. It is good to have. Or it is good to be in the state which newly draws and draws a cupline. The method of automatically recognizing and drawing the outer edge of the cup by inputting the cup line is not performed because it is difficult to recognize the outer edge of the cup with a known cup extraction recognition algorithm. This is because the automatic recognition processing usually takes a lot of processing time, so that manual editing by an operator can draw a more accurate cupline than the known method in a short time. is there.

  FIG. 8 shows an example screen for drawing a cupline. Reference numeral 61 denotes a cursor for designating a point that the operator wants to designate by mouse operation. The confirmation enlargement screen 62 is an ophthalmic image in which the C / D ratio of data 2 is drawn and a screen in which the C / D ratio is drawn on the ophthalmic image. The C / D ratio drawing line 63 of the data 1 is a line in which the C / D ratio is drawn on the image of the data 1, that is, the ophthalmic image 41. In the example of FIG. 8, the disk line input process for data 1 is completed, and the input of the cup line is next performed.

  As can be seen from FIG. 8, since the C / D ratio drawing line of the data 2 is displayed on the same image, it is visually shown which part and how much changes during the input of the C / D ratio of the data 1. Can grasp. It is also possible to calculate during the input how far the actual distance is from the difference between the changes. Further, the image of data 2 corresponding to the position of the cursor 61 is displayed on the enlargement screen 62 for confirmation from the drawing information of the position of the cursor 61 and the C / D ratio of the data 2. With this confirmation enlargement screen 62, the state of the ophthalmic image when data 2 is input can also be compared and confirmed. In the screen of the embodiment of FIG. 8, the cursor 61 points to a point on the data 2 cupline. Therefore, the confirmation enlargement screen 62 enlarges the C / D ratio screen of the data 2 indicated by the cursor 61. To display. Where the change from the data 2 is small, the confirmation enlargement screen 62 is displayed in a large size so that the small change is easy to see.

  It should be noted that the amount of movement of the point when the point is edited by reflecting the disk line of data 2 in the disk line drawing process of step S7 is the amount of movement of the point of the point editing performed in the cupline drawing process of step S8. It can also be set differently. For example, the movement amount of the point editing of the disc line is set to a movement amount that is half of the movement amount of the point editing of the cupline. With this setting, even if the amount of movement of the mouse operated by the operator is the same, the amount of movement of the point is smaller in the disk line. This setting is effective because the change of the disc line and the change of the cup line are different.

  FIG. 9 shows a screen when the cursor 61 in FIG. 8 is slightly moved. The cursor 61 is positioned off the data 2 cup line. The display of the enlargement screen 62 for confirmation changes according to the distance between the cup line 52 and the cursor 61 in the data 2. The confirmation enlargement screen 62 is reduced and displayed so that the entirety of the confirmation enlargement screen 62 can be seen, as the distance from the cupline of the data 2 increases. However, the display of the maximum reduction is not changed after a certain distance. The maximum reduction display is determined in such a size that the drawing information of the previous C / D ratio can be confirmed, that is, in a range in which the disc line is drawn in which part is drawn. Further, it is preferable that the maximum enlarged display in the case of being on the cup line is displayed at an enlargement ratio of about 2 times around the currently displayed C / D ratio drawing cursor 61.

  In this example, the display of the confirmation enlarged screen 62 is changed according to the cursor position, but the operator may change the enlarged display by operating the operation unit. For example, the ↑ and ↓ keys of the keyboard as the operation unit are assigned to enlargement and reduction, and when the key is pressed, the enlargement ratio of the display on the confirmation enlargement screen 62 may be changed according to the number of times the key is pressed. Good. For example, it is possible to display up to 100% with 5% steps.

  Further, in the case where alignment is not performed in step S5, a reduced screen in which the entire C / D ratio of data 2 is drawn may be displayed. In this case, the amount of change cannot be visually confirmed, but the C / D ratio can be input while confirming where the disk line or the cup line is drawn on the nipple.

  When the operator selects completion of drawing the cupline, the process proceeds to step S9. In step S9, the C / D ratio is calculated from the drawn disc line and cup line. In step S10, the calculation result of the C / D ratio processed in step S9 is displayed on the display. In step S11, the operator determines whether to change the point point on which the C / D ratio is drawn. In the case of editing, the disk line editing proceeds to step S71, and in the case of a cup line, the processing proceeds to step S81. The contents of the process are the same as those in steps S7 and S8, but the process starts from a process of editing a point on the drawing. When the editing of the points is completed, the process is step S9, the C / D ratio is calculated, and the result is displayed on the display. When the editing of points is completed, the process proceeds to step S12. In step S12, the selected image, the drawing information of the C / D ratio, and the measurement result are associated with each other and stored in the recording unit. This is the end of the description of the flowchart.

  Using the recorded information of data 1 and data 2 described in the flowchart, the ophthalmic images of data 1 and data 2 and the drawing information of the C / D ratio are displayed side by side, and the visual difference and the numerical difference are seen simultaneously. A screen may be provided. In addition, when data 1 and data 2 are selected and both have drawing information of C / D ratio, drawing information of C / D ratio of data 1 and data 2 is drawn on the fundus image of data 1 And display.

  An example of a comparison screen for C / D ratio drawing is shown in FIG. When it is desired to leave this image data, the image of this screen, the numerical value of the C / D ratio, and the change value are stored in the storage unit in association with this inspection data. When it is desired to output the inspection result as a report, the numerical value and the change value of the C / D ratio are output together with the comparison screen. By managing this report, you can see numerical changes and visual changes in follow-up. In addition, you may display on the comparison screen of the image and test | inspection which a normal ophthalmologic information processing system has. If you want to leave more detailed information, you can add annotations of findings and store them.

  The program according to the present invention causes a computer that stores ophthalmic images to execute the following processing. (1) Search for an image with drawing information of the previous C / D ratio of the selected first ophthalmic examination data, read the second ophthalmic examination data from the search result, and perform the first ophthalmology by image alignment processing. Drawing information of the C / D ratio of the second ophthalmic examination data is displayed on the examination data image. (2) The C / D ratio drawing information of the second ophthalmic examination data is reflected, and the operator edits the points of the C / D ratio drawing information by operating the operation unit. (3) Calculate the C / D ratio. (4) The drawing information and calculation result of the C / D ratio are stored. (5) Display the C / D ratio drawing information of the first ophthalmic examination data and the C / D ratio drawing information of the second ophthalmic examination data on the comparison screen.

  The program according to the present invention can be configured to cause the computer to execute any process described in the above embodiment. The program 25 of the above embodiment is an example of a program according to the present invention. According to the program according to the present invention, the drawing information of the previous C / D ratio can be displayed on the selected ophthalmic image. Therefore, when inputting the drawing information of the C / D ratio, This saves you the trouble of checking where you last pointed. Thereby, it is possible to improve the efficiency of input work for designating points for drawing the C / D ratio. Furthermore, according to the program according to the present invention, the drawing information of the C / D ratio can record not only the numerical change but also the visual change, so that the efficiency of follow-up observation can be improved.

  The present invention can also be realized by executing the following processing. That is, software (program) that realizes the functions of the above-described embodiments is supplied to a system or apparatus via a network or various storage media, and a computer (or CPU, MPU, or the like) of the system or apparatus reads the program. It is a process to be executed.

  1: operation unit, 2: display unit, 3: control unit, 4: storage unit, 5: ophthalmic image, 6: drawing information, 7: identification information, 8: data input unit, 9A: first ophthalmic examination data, 9B : Second ophthalmic examination data, 10: alignment unit, 11: image alignment, 12: C / D ratio drawing alignment, 13: C / D ratio input unit, 14: C / D ratio drawing input unit, 15: C / D ratio calculator

Claims (8)

Storage means for storing a first ophthalmic image and a second ophthalmic image obtained by photographing the same subject at different times;
Calculating means for obtaining a correction value for aligning the first ophthalmic image and the second ophthalmic image;
Alignment means for aligning the drawing information of the discline of the second ophthalmic image and the drawing information of the cupline of the second ophthalmic image with the first ophthalmic image using the correction value; ,
Drawing the drawing information of the discline of the second ophthalmic image and the drawing information of the cupline of the second ophthalmic image on which the alignment with the first ophthalmic image is performed on the first ophthalmic image Display means to display,
To the screen on which the first ophthalmic image displayed by the display means on which the drawing information of the discline of the second ophthalmic image and the drawing information of the cupline of the second ophthalmic image are superimposed is displayed. An ophthalmologic information processing system comprising: a receiving unit configured to receive a designation input of a disk line of the first ophthalmic image and a cupline of the first ophthalmic image. Further comprising a nipple extraction means for extracting a nipple region from an ophthalmic image;
The ophthalmologic information processing system according to claim 1, wherein alignment is performed by the alignment unit using the nipple region extracted by the extraction unit.   The ophthalmologic information processing system according to claim 2, wherein the ophthalmic information processing system performs alignment by the alignment means so that the center of the optic nerve head is best aligned.   The display means displays the drawing information of the disk line of the first ophthalmic image and the drawing information of the cup line of the first ophthalmic image, which are received by the receiving means, and the disk line of the second ophthalmic image. The ophthalmologic information processing system according to claim 1, wherein the display information is displayed in a different display manner distinguishable from the drawing information of the second ophthalmic image and the cupline of the second ophthalmic image.   When the position on the first ophthalmic image is designated by the user, the display means displays the second ophthalmic image in a region including the position on the second ophthalmic image corresponding to the designated position. The ophthalmologic information processing system according to claim 1, which is displayed.   The display means displays the second ophthalmic image with a smaller display magnification as the distance between the position designated by the user and the disc line or the cup line on the first ophthalmic image increases. The ophthalmologic information processing system according to claim 5. A calculation step of obtaining a correction value for performing alignment between the first ophthalmic image and the second ophthalmic image, which are stored in the storage means and are taken at different times of photographing the same photographing object;
An alignment step of aligning the drawing information of the discline of the second ophthalmic image and the drawing information of the cupline of the second ophthalmic image with the first ophthalmic image using the correction value; ,
Drawing the drawing information of the discline of the second ophthalmic image and the drawing information of the cupline of the second ophthalmic image on which the alignment with the first ophthalmic image is performed on the first ophthalmic image Display process to display,
To the screen on which the first ophthalmic image displayed in the display step on which the drawing information of the discline of the second ophthalmic image and the drawing information of the cupline of the second ophthalmic image are superimposed is displayed. An ophthalmologic information processing method comprising: a receiving step of receiving designation input of a discline of the first ophthalmic image and a cupline of the first ophthalmic image.   The program for making a computer perform each process of the method of Claim 7.

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