JP2013208351A - Guide wire - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a guide wire having excellent insertability into a vascular occlusive lesion by optimizing the structure and shape of the distal end of the guide wire.SOLUTION: A guide wire 1 includes: a core shaft 2; an outer coil body 3 for covering the distal end portion of the core shaft 2; an inner coil body 300 positioned inside the outer coil body 3 and covering the distal end portion of the core shaft 2; and a distal-most end 5 for fixing the distal ends of the core shaft 2 and outer coil body 3 to the distal end of the inner coil body 300. The distal end of the inner coil body 300 is arranged so as to be positioned in the direction of the further distal end from the distal end of the outer coil body.

Description

  The present invention relates to a guide wire.

  Conventionally, various guide wires have been proposed which are used to guide a medical device or the like to a target site by being inserted into a tubular organ such as a blood vessel, a digestive tract, or a ureter or a body tissue. Recently, many medical treatments using a guide wire have been performed on vascular occlusion lesions that cause ischemic diseases. In particular, in recent years, it has been found that a fine path (hereinafter referred to as a microchannel) exists in the vascular occlusion lesion, and the currently developed guide wire includes the vascular occlusion lesion and vascular occlusion. The pushability of the guide wire to the microchannel existing in the lesion is required.

  For example, Patent Document 1 describes a guide wire having a double coil body structure.

  Further, Patent Document 2 includes a twisted wire and a blade wire at the tip of the core shaft, and further provided with a tip at the tip that is formed by welding, and the tip has a reduced outer diameter toward the tip. Alternatively, a guide wire formed in a chisel shape is described.

US Pat. No. 5,345,945 US Publication No. 2007/0185415

  However, the guide wire described in Patent Document 1 does not describe the position of the tip of the outer coil body and the tip of the inner coil body in detail, and in another embodiment, the tip or base of the inner coil body is not described. A structure having a structure in which the end is separated from the fixing portion with the core shaft is disclosed, and in such a guide wire, stress applied to the inner coil when the guide wire is pushed is applied to the distal end of the guide wire. As a result, there was a problem in the pushability of the guide wire to the vascular occlusion lesion or the like.

  In addition, the guide wire described in the cited document 2 has an insertion property on the entrance side of the microchannel due to the tip having a reduced outer diameter, but the stranded wire and the blade wire are flexible. There was a problem in the pushability of the guide wire to the part.

  The present invention has been made in view of such problems, and an object of the present invention is to provide a guide wire having excellent pushability of the guide wire to a vascular occluded lesion or the like.

  <1> The invention according to claim 1 of the present application is a core shaft, an outer coil body that covers at least a tip portion of the core shaft, and an inner coil that is positioned inside the outer coil body and covers the tip portion of the core shaft. A body, a distal end of the core shaft, a distal end of the outer coil body, and a distal end of the inner coil body, and the distal end of the inner coil body includes the outer coil. It features a guidewire located at the tip rather than the tip of the body.

  <2> The invention according to claim 2 is the guide wire according to claim 1, wherein the inner coil body has a coil outer diameter that decreases toward the tip of the inner coil body at least in the most distal portion. Features a guidewire that is

  <3> The invention according to claim 3 is the guide wire according to claim 1 or 2, wherein the outer coil body has a coil outer diameter toward the tip of the outer coil body at least in the most distal portion. Featuring a reduced guidewire.

  <4> The invention according to claim 4 is the guide wire according to any one of claims 1 to 3, wherein the distal end of the core shaft is located further in the distal direction than the distal end of the inner coil body. Features a guidewire that is

  <5> The invention according to claim 5 is characterized in that, in the guide wire according to claim 4, the distal end portion of the core shaft is exposed at the distal end surface of the most distal end portion.

  <6> The invention according to claim 6 is the guide wire according to any one of claims 1 to 5, wherein the tip of the inner coil body is exposed on the surface of the tip of the most distal portion. Features a guidewire that is

  <1> In the guide wire according to claim 1, the distal end of the core shaft, the distal end of the outer coil body, and the distal end of the inner coil body are fixed at the most distal portion, and the distal end of the inner coil body is the outer coil. Since it is located in the direction of the tip rather than the tip of the body, it becomes easy to transmit the force applied to the inner coil body to the most advanced part. As a result, the force applied to the proximal end side of the guide wire can be efficiently transmitted to the most distal portion 5 and, in turn, the push-in force of the guide wire against the vascular occluded lesion can be improved.

  <2> In the guide wire according to claim 2, the inner coil body in the most distal portion has a tapered outer shape because the outer diameter of the coil decreases toward the tip of the inner coil body. However, since the force applied to the inner coil body can be transmitted to the most distal portion, the pushability of the guide wire to the vascular occlusion lesion can be improved.

  <3> In the guide wire according to claim 3, since the outer diameter of the outer coil body in the most distal portion decreases toward the tip of the outer coil body, the outer diameter of the most distal portion is further reduced. Since the diameter can be increased, the insertion property of the guide wire into the vascular occlusion lesion or the like can be improved, and further, the pushability of the guide wire can be further improved.

  <4> Since the distal end of the core shaft is located in the distal direction relative to the distal end of the inner coil body, the guide wire according to the fourth aspect is the most advanced in consideration of the insertion property to the vascular occlusion lesion. Even when the shape of the portion is tapered, the force applied to the core shaft can be more easily transmitted to the most distal portion, and the pushability of the guide wire to the vascular occluded lesion can be further improved.

  <5> In the guide wire according to claim 5, since the tip of the core shaft is exposed on the tip surface of the most distal portion, the shape of the most distal portion is taken into consideration for insertion into a vascular occlusion lesion. Even in the case of a tapered shape, the force applied to the core shaft can be reliably transmitted by the most advanced portion, and the pushability of the guide wire to the vascular occluded lesion can be greatly improved.

  <6> In the guide wire according to claim 6, since the tip of the inner coil body is exposed on the surface of the tip of the most distal portion, the force applied to the inner coil body is maximized at the most distal portion. Therefore, the pushability of the guide wire to the vascular occlusion lesion or the like can be greatly improved.

1 is an overall view of a guide wire showing a first embodiment of the present invention. It is a block diagram of the guide wire which shows 2nd Embodiment of this invention, (a) is a general view of a guide wire, (b) is the figure which expanded the vicinity of the front-end | tip part of (a), c) is an enlarged view of the vicinity of the foremost portion, which is a modification of the inner coil body of the present embodiment. It is a general view of the guide wire which shows 3rd Embodiment of this invention. It is a general view of the guide wire which shows 4th Embodiment of this invention. It is a block diagram of the guide wire which shows 5th Embodiment of this invention, (a) is a general view of a guide wire, (b) is the figure which expanded the vicinity of the most advanced part of (a), (c) is a figure when it sees toward the base end direction from the front-end | tip of (b). It is a block diagram of the guide wire which shows 6th Embodiment of this invention, (a) is a general view of a guide wire, (b) is the figure which expanded the vicinity of the forefront part of (a). It is a general view of the guide wire which shows 7th Embodiment of this invention.

  Hereinafter, a guide wire of the present invention will be described based on a preferred embodiment shown in the drawings.

<First Embodiment>
FIG. 1 is an overall view showing a guide wire according to a first embodiment of the present invention.

In FIG. 1, for convenience of explanation, the left side is described as “base end” and the right side is described as “tip”.
Moreover, in FIG. 1, since the length direction of the guide wire 1 is shortened and the whole guide wire 1 is typically illustrated for easy understanding, the overall dimensions are different from actual ones.

  In FIG. 1, a guide wire 1 includes a core shaft 2, an outer coil body 3 that covers the tip portion of the core shaft 2, and an inner coil body 300 that is positioned inside the outer coil body 3 and covers the tip portion of the core shaft 2. And the most advanced portion 5 for fixing the tip of the core shaft 2, the tip of the outer coil body 3, and the tip of the inner coil body 300 to each other. In the base end direction of the most distal portion 5, the outer coil body 3 and the core shaft 2 are fixed by the first intermediate fixing portion 7 and the second intermediate fixing portion 17, and the base end of the coil body 3 and the core shaft 2 are fixed. Is fixed by the first base end fixing portion 9. Further, the base end of the inner coil body 300 and the core shaft 2 are fixed by the second base end fixing portion 39.

  The distal end of the inner coil body 300 is positioned further in the distal direction than the distal end of the outer coil body 3 in the positional relationship in the most distal portion 5 between the distal end of the outer coil body 3 and the distal end of the inner coil body 300. Has been. As a more preferable arrangement form, as in this embodiment, when the total length of the most distal portion 5 in the longitudinal direction of the guide wire 1 is divided into two, the tip end portion is temporarily distinguished from Td, and the base end portion is temporarily distinguished from Tp. A configuration in which the distal end of the outer coil body 3 is disposed so as to be located in the proximal end portion Tp of the most distal end portion 5, and the distal end of the inner coil body 300 is disposed in the distal end portion Td of the most distal end portion 5. It is.

As described above, the tip of the inner coil body 300 is arranged in the tip direction further than the tip of the outer coil body 3 in the most distal portion 5, so that it is added to the inner coil body 300. It becomes easy to transmit force to the most advanced part 5. As a result, the force applied to the proximal end side of the guide wire 1 can be efficiently transmitted to the most distal portion 5, and as a result, the indentation of the guide wire 1 against the vascular occluded lesion can be improved. .
In addition, the inner coil body 300 is disposed so that the distal end thereof is located in the distal end portion Td of the most distal end portion 5, and the distal end of the outer coil body 3 is disposed in the proximal end portion Tp of the most distal end portion 5. Therefore, it becomes easier to transmit the force applied to the inner coil body 300 to the distal end portion Td of the most distal portion 5, and further improve the pushability of the guide wire 1 to the vascular occluded lesion portion or the like. Can do.

  In addition, as for the positional relationship between the tip of the inner coil body 300 and the outer coil body 3 in the most distal portion 5, as described above, the arrangement form of the present embodiment is a preferable form. If the configuration is such that the tip of the inner coil 300 is positioned in the tip direction relative to the tip of the outer coil body 3, for example, the tip of the inner coil 300 and the tip of the outer coil body 3 are The form arrange | positioned in the front-end | tip part Td and the base end part Tp may be sufficient.

  In the following description of the embodiments, the distal end portion of the most distal end portion 5 and the proximal end portion of the most distal end portion 5 are the full length of the most distal end portion 5 in the longitudinal direction of the guide wire 1 unless otherwise specified. Is divided into two, and the distal end side from the middle is the distal end portion of the most distal end portion 5 and the proximal end side from the middle is the proximal end portion of the most distal end portion 5.

  Hereinafter, the material of each element in the present embodiment will be described. The material for forming the core shaft 2 is not particularly limited. For example, a material such as stainless steel (SUS304), a superelastic alloy such as a Ni—Ti alloy, or a piano wire can be used.

  The most advanced portion 5 that fixes the core shaft 2, the outer coil body 3, and the inner coil body 300, the first intermediate fixing portion 7 that fixes the core shaft 2 and the outer coil body 3, and the second intermediate fixing portion 17. As the material of the first base end fixing portion 9 and the second base end fixing portion 39 that fixes the core shaft 2 and the inner coil body 300, for example, epoxy adhesive, aluminum alloy brazing, silver brazing , Gold solder, zinc, Sn—Pb alloy, Pb—Ag alloy, Sn—Ag, Au—Sn alloy, and the like, and it is preferable to use metal solder from the viewpoint of fixing strength and mechanical strength. Alternatively, the tip 5 may be formed by welding the tip of the core shaft 2, the tip of the outer coil body 3, and the tip of the inner coil body 300.

  In particular, in the most advanced portion 5, it is preferable to use a metal solder such as an Au—Sn alloy mainly composed of gold. Such a metal solder such as an Au—Sn alloy is known to have high rigidity, and when the most advanced portion 5 is formed of the Au—Sn alloy, the rigidity of the most advanced portion 5 is improved. The fixing strength of the tip of the core shaft 2, the tip of the outer coil body 3, and the tip of the inner coil body 300 can be increased, and is added to the core shaft 2, the outer coil body 3, and the inner coil body 300. Since it can be used at the distal end of the guide wire 1 without attenuating the applied force at the most distal portion 5, it is possible to further improve the push-in life of the guide wire 1 with respect to the vascular occlusion lesion or the like.

  Moreover, since metal solder like Au-Sn alloy has the outstanding radiopacity, the visibility under the radiographic image of the most distal part 5 of the guide wire 1 can be improved. As a result, the surgeon can operate the guide wire 1 while clearly grasping the position of the guide wire 1 in the vascular occlusion lesion, so that the guide wire 1 passes through the vascular occlusion lesion. Works in favor.

  Further, when metal solder is used in each of the fixing portions described above, it is preferable to apply a flux in advance to the position where the fixing is performed. Thereby, the wettability of the metal solder with respect to the core shaft 2, the outer coil body 3, and the inner coil body 300 becomes favorable, and the fixing strength can be increased.

Further, as a material for forming the outer coil body 3 and the inner coil body 300, a wire having radiopacity or a wire having radiolucency can be used.
The material of the wire having radiopacity is not particularly limited. For example, gold, platinum, tungsten, or an alloy containing these elements (for example, platinum-nickel alloy) is used. Can do.
Further, the material of the wire having radiation transparency is not particularly limited, but for example, stainless steel (SUS304, SUS316, etc.), super elastic alloy such as Ni-Ti alloy, piano wire, or the like is used. be able to.

In addition, in order to provide the visibility of the distal end of the guide wire 1 under radioscopy, at least one of the strands constituting the outer coil body 3 and the inner coil body 300 is radiopaque. It is preferable to use a strand.
Further, the outer coil body 3 and the inner coil body 300 may be constituted by a single-strand coil body composed of one strand, or a multi-strand coil body composed of two or more strands. It can also be configured. Moreover, it is preferable to comprise either the outer side coil body 3 or the inner side coil body 300 with the multi-strand coil body which is excellent in pushing property rather than a single strip coil body. Furthermore, it is most preferable that the inner coil body 300 is composed of a multi-strand coil body.

  Although the outer peripheral surface of the outer coil body 3 may be in direct contact with the flexible inner wall of the blood vessel, the outer peripheral surface of the inner coil body 300 is not directly in contact with the inner wall of the blood vessel due to its structure, and is affected by external influences. hard. For this reason, the force added to the inner side coil body 300 can be efficiently transmitted to the most advanced part 5 by comprising the inner side coil body 300 by a multi-strip | row coil body.

  Moreover, it is preferable to arrange | position the inner side coil body 300 on the core shaft 2 so that the inner side coil body 300 may become a form which covers at least one part of the thinnest part of the core shaft 2 like a present Example. Thereby, the core shaft 2 can be protected, and the force applied to the core shaft 2 can be reliably transmitted to the most advanced portion 5 together with the core shaft 2 and the inner coil body 300 without escaping to the outside.

  Moreover, it is preferable that at least one of the outer coil body 3 and the inner coil body 300 is in a closely wound form in which the coil strands are densely arranged. Further, both the outer coil body 3 and the inner coil body 300 are formed. It is more preferable to use a densely wound form.

  Thus, by making the outer coil body 3 and the inner coil body 300 into a tightly wound form, the force applied to each coil body can be reliably transmitted by the most advanced portion 5.

  In order to facilitate the formation of the first intermediate fixing portion 7 and the like, in the case where a gap is provided in a part between the coil wires of the outer coil body 3, the outer coil is provided if the gap is filled with a fixing member. The body 3 can be regarded as a tightly wound form.

  In the present embodiment, the outer coil body 3 is a single-strand coil body formed of a densely wound form of one strand, and the inner coil body 300 is not shown in detail, but 12 strands (SUS304). ) In the form of multiple windings.

The guide wire 1 of this embodiment can be produced by the following method.
First, one end of a metal wire used as a material for the core shaft is peripherally ground by a centerless polishing machine to prepare the core shaft 2 in which the outer diameter of the tip portion is reduced.

Further, the wire for the outer coil body 3 is wound around the core bar for the outer coil body 3, and heat treatment is performed in a state where the coil wire is wound around the core bar for the outer coil body 3. The core metal for the coil body 3 is extracted and the outer coil body 3 is prepared.
Further, twelve strands are twisted on the core for the inner coil body 300 using a twisting machine, and heat treatment is performed with the coil strand twisted on the core for the inner coil body 300. Then, the core for the inner coil body 300 is removed to prepare the inner coil body 300.

  Next, the distal end of the core shaft 2 is inserted from the proximal end of the inner coil body 300, and the proximal end of the inner coil body 300 and the core shaft 2 are fixed with metal solder to form the second proximal end fixing portion 39. Then, the tip of the inner coil body 300 and the tip of the core shaft 2 are temporarily fixed with metal solder.

  Next, the distal end of the core shaft 2 to which the inner coil body 300 is fixed is inserted from the proximal end of the outer coil body 3 so that the distal end of the inner coil body 300 is located on the distal side of the distal end of the outer coil body 3. The position of the outer coil body 3 is adjusted, and in this state, the base end of the outer coil body 3 and the core shaft 2 are fixed with metal solder to form the first base end fixing portion 9.

  Next, the tip of the outer coil body 3 and the tip of the core shaft 2 to which the inner coil body 300 is fixed are fixed with metal solder to form the foremost portion 5.

  Next, the two intermediate portions of the outer coil body 3 and the core shaft 2 are fixed with metal solder to form the first intermediate fixed portion 7 and the second intermediate fixed portion 17.

  And finally, in order to make the shape of the most advanced portion 5 into a tapered shape, the outer periphery of the most advanced portion 5 is polished by a device such as a reuter to adjust the shape of the most advanced portion 5.

  In addition, you may produce the guide wire 1 not only by the manufacturing method and order mentioned above but by a well-known method.

Second Embodiment
Next, the guide wire 11 of 2nd Embodiment is demonstrated centering on a different point from 1st Embodiment using FIG. Portions common to the first embodiment are denoted by the same reference numerals in the drawing.
In FIG. 2, for ease of understanding, the length direction of the guide wire 11 is shortened and the entire guide wire 11 is schematically illustrated, so that the overall dimensions are different from the actual dimensions.
2A is an overall view of the guide wire, FIG. 2B is an enlarged view of the vicinity of the leading edge of FIG. 2A, and FIG. 2C is an enlarged view of the vicinity of the leading edge of this embodiment. It is the figure which was made, and is a figure which shows the modification of an inner side coil body.

  2 (a) and 2 (b), the guide wire 11 has a portion 330 in which the coil outer diameter of the distal end portion of the inner coil body 301 decreases as it goes in the distal end direction, and the most distal portion. The configuration is the same as the guide wire 1 of the first embodiment except that the shape of 15 is further tapered toward the tip.

In order to make the outer diameter of the most advanced portion 15 smaller, a portion 330 where the outer diameter of the coil of the inner coil body 301 is reduced is as shown in FIG. However, the present invention is not limited to this, and the coil outer diameter of the inner coil body 301 is reduced. The inner coil body 301 may be arranged so that the boundary with the portion 330 that is present is located in the most distal portion 15.
Moreover, although the form of the part 330 in which the coil outer diameter of the inner side coil body 301 is reducing is made into the linear form in this embodiment, it may be made into a curvilinear form, and the form to which a coil outer diameter reduces in steps. But it ’s okay.

  As described above, since the coil outer diameter of the distal end portion of the inner coil body 301 in the most distal portion 15 has the portion 330 that decreases as it goes in the distal end direction, insertion into a vascular occlusion lesion is considered. Even when the outer diameter of the most distal portion 15 is reduced, the force applied to the inner coil body 301 can be efficiently transmitted to the most distal portion 15. The indentation characteristic can be improved.

  The inner coil body 301 having the portion 330 in which the outer diameter of the coil is reduced is obtained by electrolytic polishing, polishing with a router, centerless polishing, or the like in a state where a core metal is inserted into the inner coil body 301. It can be manufactured by polishing the tip of the body 301.

  Further, as shown in FIG. 2 (c), by using the inner coil body 302 in which the outer diameter of the coil and the inner diameter of the coil are reduced in the direction of the tip, the shape of the most advanced portion 15 is further tapered. As a result, the push-in characteristic of the guide wire 11 against a vascular occlusion lesion or the like can be further improved.

  Such an inner coil body 302 can be manufactured by forming a core bar for the inner coil body 302 into a tapered shape and winding a coil wire around the core bar.

<Third Embodiment>
Next, the guide wire 21 according to the third embodiment will be described with reference to FIG. 3 focusing on differences from the second embodiment. The parts common to the second embodiment are denoted by the same reference numerals in the drawing.
In FIG. 3, in order to facilitate understanding, the length direction of the guide wire 21 is shortened and the entire guide wire 21 is schematically illustrated, and thus the overall dimensions are different from the actual dimensions.

  In FIG. 3, the guide wire 21 has a portion 103 in which the outer coil body 13 has a constant coil outer diameter and a portion 113 in which the outer coil body 13 has a coil outer diameter that decreases toward the tip. In addition, the configuration is the same as that of the guide wire 11 of the second embodiment except that the shape of the most distal portion 25 is further tapered toward the tip.

In order to further reduce the outer diameter of the most distal portion 25, the portion 113 where the outer diameter of the outer coil body 13 is reduced is formed in the most distal portion 25 as shown in FIG. However, the present invention is not limited to this, and the outer coil body 13 is arranged so that the portion 103 having a constant outer diameter of the outer coil body 13 is located in the most distal portion 25. It may be arranged.
Moreover, although the reduction | decrease form of the coil outer diameter of the outer side coil body 13 is made into the linear form in this embodiment, a curved form may be sufficient and the form which a coil outer diameter reduces in steps may be sufficient.

  Thus, since the outer diameter of the coil at the distal end portion of the outer coil body 13 in the most distal portion 15 decreases toward the distal end direction, the outer diameter of the most distal portion 25 can be further reduced. Therefore, the insertion property of the guide wire 21 with respect to a vascular occlusion lesion or the like can be improved, and further, the pushing characteristic of the guide wire 21 can be further improved.

  Such an outer coil body 13 can be obtained by polishing the tip of the outer coil body 13 by electrolytic polishing, polishing with a router, centerless polishing, or the like with a core metal inserted into the outer coil body 13, The outer coil body 13 having the portion 113 in which the outer diameter of the coil is reduced can be produced by a method in which a coil wire is wound around a core metal having a reduced diameter.

<Fourth embodiment>
Next, a guide wire 31 according to the fourth embodiment will be described with reference to FIG. 4 focusing on differences from the first embodiment. Portions common to the first embodiment are denoted by the same reference numerals in the drawing.
In FIG. 4, in order to facilitate understanding, the length direction of the guide wire 31 is shortened and the entire guide wire 31 is schematically illustrated, and thus the overall dimensions are different from the actual dimensions.

  In FIG. 4, the guide wire 31 has the same configuration as the guide wire 1 of the first embodiment except that the tip of the core shaft 2 is located further in the tip direction than the tip of the inner coil body 300. .

  As described above, the guide wire 31 according to the fourth embodiment has the distal end of the core shaft 2 positioned in the distal end direction with respect to the distal end of the inner coil body 300, so that the force applied to the core shaft 2 is the most advanced. Since it becomes easier to transmit to the part 5, the pushability of the guide wire 31 with respect to the vascular occlusion lesion part etc. can be improved further. In addition, this effect can further improve the pushability of the guide wire 111 against a vascular occluded lesion or the like even when the distal end portion 15 has a tapered shape like the guide wire 11 of the second embodiment. it can.

  The tip of the core shaft 2 may be disposed in the most distal portion 5 in a state of being located in the tip direction with respect to the tip of the inner coil body 300, but the force applied to the core shaft 2 is the most advanced. In order to efficiently transmit to the portion 5, it is preferable that the tip position of the core shaft 2 is exposed on the tip surface of the most distal portion 5 as in the present embodiment.

  As described above, in the guide wire 31 of the fourth embodiment, the tip of the core shaft 2 is exposed on the tip surface of the most distal portion 5, so that the force applied to the core shaft 2 is applied to the most distal portion 5. Furthermore, since it can transmit efficiently, the pushability of the guide wire 31 with respect to the vascular occlusion lesion part etc. can be improved significantly. In addition, this effect greatly improves the pushability of the guide wire 111 against a vascular occluded lesion or the like even when it has a tapered tip 15 like the guide wire 11 of the second embodiment. Can do.

  The form in which the tip of the core shaft 2 is exposed at the tip surface of the most distal portion 5 is a form in which the entire tip surface of the core shaft 2 is exposed at the tip surface of the most distal portion 5, It includes a form in which a part of the tip surface is exposed on the tip surface of the most distal portion 5.

  Moreover, it is preferable that the outer diameter of the thinnest part of the core shaft 2 is larger than at least the coil wire diameter of the inner coil body 300. By making the outer diameter of the thinnest part of the core shaft 2 larger than the coil wire diameter of the inner coil body 300, the pushing force of the core shaft 2 can be easily transmitted by the most advanced portion 5, and Can greatly improve the pushability of the guide wire 31 to a vascular occlusion lesion or the like.

<Fifth Embodiment>
Next, the guide wire 41 according to the fifth embodiment will be described with reference to FIGS. 5A to 5C focusing on differences from the fourth embodiment. Parts common to the fourth embodiment are denoted by the same reference numerals in the drawing.
In FIG. 5A, the length direction of the guide wire 41 is shortened and the entire guide wire 41 is schematically shown for easy understanding, and therefore the overall dimensions are different from the actual dimensions. .
5A is an overall view of the guide wire 41, FIG. 5B is an enlarged view of the vicinity of the most distal portion of FIG. 5A, and FIG. 5C is FIG. It is a figure at the time of visually observing toward the base end direction from the front-end | tip of b).

  5A, 5 </ b> B, and 5 </ b> C, the guide wire 41 is the fourth except that the tip of the inner coil body 300 is exposed on the surface of the tip of the most distal portion 5. It is the same structure as the guide wire 31 of embodiment.

  Thus, since the tip of the inner coil body 300 is exposed on the surface of the tip portion of the most distal portion 5, the guide wire 41 of the fifth embodiment applies the force applied to the inner coil body. 5 and the pushability of the guide wire 41 to the vascular occlusion lesion or the like can be greatly improved. In addition, this effect greatly improves the pushability of the guide wire 11 against a vascular occluded lesion or the like even when the distal end portion 15 has a tapered shape like the guide wire 11 of the second embodiment. Can do.

  Note that the form in which the tip of the coil body 300 is exposed on the surface of the tip portion of the most distal portion 5 is that all the coil strands of the coil body 300 are the most advanced as shown in FIG. The form exposed on the surface of the tip part of the part 5 or the form where at least a part of the coil wire of the coil body 300 is exposed on the surface of the tip part of the most distal part 5 although not shown. Contains.

<Sixth Embodiment>
Next, the guide wire 51 according to the sixth embodiment will be described with reference to FIGS. 6A and 6B, focusing on differences from the fifth embodiment. Parts common to the fifth embodiment are denoted by the same reference numerals in the drawing.
In FIG. 6A, the length of the guide wire 51 is shortened and the entire guide wire 51 is schematically shown for easy understanding, so the overall dimensions are different from the actual dimensions. .
FIG. 6A is an overall view of the guide wire 51, and FIG. 6B is an enlarged view of the vicinity of the most distal portion of FIG. 6A.

  6 (a) and 6 (b), the most distal portion 35 is provided at the distal end of the outer diameter reducing portion 35a whose outer diameter linearly decreases in the distal direction and the outer diameter reducing portion 35a. A portion having a hemispherical shape portion 35b, a portion 103 having a constant coil outer diameter of the outer coil body 23, and a tapered portion 113 in which the coil outer diameter of the outer coil body 23 decreases toward the tip. Is the same as that of the fifth embodiment.

In the present embodiment, the distal end of the outer coil body 23 is fixed to the inner coil body 300 and the core shaft 2 by the most distal portion 35 before the outer diameter reducing portion 35 a of the most distal portion 35.
The tip of the inner coil body 300 is disposed so as to be exposed on the surface of the outer diameter reduced portion 35 a of the most distal portion 35.
Further, the distal end of the core shaft 2 is located in the distal direction relative to the distal end of the inner coil body 300 and is disposed so as to be located in the hemispherical portion 35 b of the most distal portion 35.

  Thus, the guide wire 51 of the present embodiment has an outer diameter reducing portion 35a in which the outer diameter of the most distal portion 35 linearly decreases in the distal direction, and a hemispherical shape located at the tip of the outer diameter reducing portion 35a. Therefore, the pushability of the guide wire 51 to the vascular occlusion lesion or the like can be greatly improved.

  Moreover, since the outer coil body 23 has the taper part 113 which the outer side coil body 23 reduces toward a front-end | tip, the guide wire 51 of this embodiment has the thick outer diameter by the side of the hand of the guide wire 51, and the front-end | tip of the guide wire 51 Since the outer diameter of the guide wire 51 is thin, the torque on the proximal side of the guide wire 51 can be efficiently transmitted to the tip, and the coil outer diameter of the outer coil body 23 decreases toward the tip. Therefore, since the vector of the pushing force applied to the guide wire 51 can be directed toward the center of the distal end of the guide wire 51, the vascular occlusion lesion portion can be obtained even when the most distal portion 35 has a tapered shape. It is possible to greatly improve the pushability of the guide wire 51 with respect to the above.

  In the present embodiment, the most distal portion 35 has a portion with a constant outer diameter at the base end of the outer diameter reducing portion 35a, and the tapered portion 113 of the outer coil body 23 is at the tip of the outer diameter constant portion. Are fixed to the inner coil body 300 and the core shaft 2 in a state where the tip of the inner coil body is located. Thereby, the front-end | tip of the taper part 113 of the outer side coil body 23 and the base end of the outer diameter reduction | decrease part 35a of the most distal part 35 are arrange | positioned in the continuous positional relationship.

In addition, as shown in FIG. 6B, the guide wire 51 of the present embodiment has a tapered portion 113 in which the outer diameter of the outer coil body 23 decreases toward the tip. The foremost portion 35 also has an outer diameter reducing portion 35a in which the outer diameter of the coil decreases in the distal direction.
Here, an angle formed between a straight line Lp parallel to the long axis direction center line Lc of the guide wire 51 and a tangent line Lt1 of the tapered portion 113 of the coil body 23 is θ1, and the guide wire center line Lc and the most distal portion 35 are The relationship between the angle θ1 of the taper portion 113 of the coil body 23 and the angle θ2 of the outer diameter reduction portion 35a of the most distal portion 35 is θ2> θ1 when the angle formed with the tangent Lt2 of the outer diameter reduction portion 35a is θ2. It has become. That is, the degree of outer diameter reduction per unit length in the long axis direction is that the outer diameter reduction degree of the outer diameter reducing part 35a of the most distal portion 35 is less than the outer diameter reduction degree of the tapered portion 113 of the coil body 23. It is getting bigger.
The outer diameter reducing portion 35a of the most distal portion 35 may have a curved shape or a stepped shape. However, in consideration of the insertion property in the vascular occlusion lesion, the shape is linear as in the present embodiment. A form in which the outer diameter decreases is preferable. Further, even when the shape of the outer diameter reducing portion 35a of the most distal portion 35 is curvilinear or stepwise, the outer diameter reduction degree of the line segment connecting the proximal end and the distal end of the most distal portion 35 in the major axis direction is as follows. The outer diameter reduction degree of the tapered portion 113 of the coil body 23 is larger.

  As described above, in the guide wire 51 of the present embodiment, the outer diameter reduction degree of the outer diameter reduction part 35a of the most distal part 35 is larger than the outer diameter reduction degree of the taper part 113 of the outer coil body 23. When the guide wire 51 passes through the lesioned portion, the resistance between the proximal end of the outer diameter reducing portion 35a of the most distal portion 35 and the distal end of the tapered portion 113 of the coil body 23 can be reduced. The pushability of the guide wire 51 to the vascular occlusion lesion or the like can be greatly improved.

  The outer diameter reduced portion 35a and the hemispherical portion 35b of the most advanced portion 35 may be formed from different metal brazing materials or the like, but the most advanced portion 35 is formed with a metal brazing material or the like, and then The outer diameter reduced portion 35a and the hemispherical portion 35b can also be formed by polishing the surface of the most advanced portion 35 by a known method such as a leuter.

<Seventh embodiment>
Next, a guide wire 61 according to the seventh embodiment will be described with reference to FIG. 7, focusing on differences from the sixth embodiment. Parts common to the sixth embodiment are denoted by the same reference numerals in the drawing.
In FIG. 7, for ease of understanding, the length of the guide wire 61 is shortened and the entire guide wire 61 is schematically illustrated, and thus the overall dimensions are different from the actual dimensions.

  In FIG. 7, the tip of the outer coil body 23 is located in the outer diameter reducing portion 35 a of the most distal portion 35, and the tip of the inner coil body 300 is located in the hemispherical portion 35 b of the most distal portion 35. The configuration is the same as that of the sixth embodiment except that the tip of the core shaft 2 is exposed on the surface of the hemispherical portion 35b of the most distal portion 35.

As described above, in the guide wire 61 of the present embodiment, the distal end of the outer coil body 23 is located in the outer diameter reducing portion 35a of the most distal portion 35, and the distal end of the inner coil body 300 is a hemispherical portion of the most distal portion 35. Since the guide wire 61 has the tapered leading edge 35, the force applied to the outer coil body 23 and the inner coil 300 is efficiently transmitted to the leading edge 35. Therefore, the pushability of the guide wire 61 to the vascular occlusion lesion or the like can be greatly improved.
Since the tip of the core shaft 2 is exposed on the surface of the hemispherical portion 35b of the most distal portion 35, the core shaft 2 can be used even when the guide wire 61 has the tapered most distal portion 35. Since the force applied to can be more efficiently transmitted to the most advanced portion 35, the pushability of the guide wire 61 to the vascular occlusion lesion or the like can be greatly improved.

  Further, the present invention is not limited to the above-described embodiments, and various modifications can be made by those skilled in the art within the technical idea of the present invention.

  For example, the distal end position of the inner coil body 300 of the guide wire 61 of the seventh embodiment is arranged so as to be located in the outer diameter reducing portion 35a of the most distal portion 35 as in the guide wire 51 of the sixth embodiment. May be.

  Thus, in the guide wire 61 in which the distal end position of the inner coil body 300 is in the outer diameter reducing portion 35a of the most distal portion 35, the distal end of the outer coil body 23 is positioned in the outer diameter reducing portion 35a of the most distal portion 35. In addition, since the tip of the inner coil body 300 is located in the outer diameter reducing portion 35a of the most distal portion 35, the force applied to the outer coil body 23 and the inner coil 300 is efficiently transmitted to the most distal portion 35. Therefore, the pushability of the guide wire 61 to the vascular occlusion lesion or the like can be greatly improved.

Further, the inner coil body 301 having the portion 330 in which the coil outer diameter is reduced applied to the guide wire 11 of the second embodiment and the inner coil body 302 in which the coil outer diameter and the inner diameter are reduced toward the tip are used. It can also be used in other embodiments.
Further, the outer coil body 23 having the tapered portion 113 of the sixth embodiment or the seventh embodiment can be used in the first to fifth embodiments.

  Further, in order to improve the slipperiness between the guide wire and the vascular occlusion lesion part, a lubricating coating layer may be provided on the surface of the coil body or the most advanced part of the first to seventh embodiments.

  By providing such a lubricious coating layer on the surface of the coil body or the most advanced part, the slipperiness between the guide wire and the vascular occlusion lesion is improved. It can also be improved.

  Examples of such a lubricious coating layer include, but are not limited to, hydrophobic coating materials such as silicone oil and fluororesin, or polyvinylpyrrolidone, polyacrylic acid, polyacrylamide, polyvinyl alcohol, anhydrous A hydrophilic coating material such as maleic acid copolymer or hyaluronic acid can be used.

1, 11, 21, 31, 41, 51, 61 Guide wire 2 Core shaft 3, 13, 23 Outer coil body 300, 301, 302 Inner coil body 5, 15, 25, 35 Most advanced part 35a Outer diameter reducing part 35b Hemispherical portion 7 First intermediate fixing portion 17 Second intermediate fixing portion 9 First base end fixing portion 39 Second base end fixing portion

Claims (6)

A core shaft;
An outer coil body covering at least the tip of the core shaft;
An inner coil body that is located inside the outer coil body and covers a tip of the core shaft;
A distal end portion that fixes the tip of the core shaft, the tip of the outer coil body, and the tip of the inner coil body,
The guide wire, wherein the tip of the inner coil body is located at the tip of the tip of the outer coil body. The guidewire according to claim 1, wherein
The guide wire, wherein the inner coil body has a coil outer diameter decreasing toward the tip of the inner coil body at least in the most distal portion. The guide wire according to claim 1 or 2,
The guide wire, wherein the outer coil body has a coil outer diameter decreasing toward the tip of the outer coil body at least in the most distal end portion. In the guide wire as described in any one of Claims 1-3,
A guide wire in which a tip of the core shaft is located further in a tip direction than a tip of the inner coil body. The guide wire according to claim 4,
A guide wire in which a tip end portion of the core shaft is exposed on a tip end surface of the most distal end portion. In the guide wire according to any one of claims 1 to 5,
A guide wire, wherein a tip of the inner coil body is exposed on a surface of a tip of the most distal portion.

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