JP2013132231A - Support for volatile agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a support for volatile agents, capable of effective and economical utilization accounting for keeping the evaporation rate of the agent even by preserving the volatile agent for a long time, and also having good user friendliness and ecology due to being disposable without separating it into parts after use.SOLUTION: The support capable of supporting or holding a carrier for volatile agents is produced by kneading paper fibers and a water-soluble polymer binder with water, forming the obtained main raw material and drying the formed product with heat.

Description

  The present invention relates to a support for a volatile drug that supports a drug carrier that holds a volatile drug such as an insecticide, a deodorant, and a fragrance. In more detail, it is related with the support body which hold | maintains or accommodates a volatile chemical | medical agent also including structures, such as a container.

Various products have been provided for products that volatilize volatile chemicals. For example, a filter paper impregnated with a room temperature volatile insect repellent such as a pyrethroid agent and stored in a container made of polypropylene or the like is widely provided as an insect repellent for a chiffon or a closet. In addition, the space in which an impregnated fragrance used for deodorization masking in entrances, toilets, cars, etc., is carried in a container made of polyethylene, polypropylene, etc. with air permeability. It is widely provided as a deodorant and fragrance product.
Various products such as insect repellents and fragrances that volatilize (release) volatile chemicals as described above (hereinafter described as insect proof / fragrance products) are chemicals such as filter papers that carry volatile chemicals as described above. Generally, it is composed of a carrier and a container (support for volatile medicine) having an opening for volatilizing the volatile medicine while storing and holding the medicine carrier.

  However, when a container such as that described above is molded from polyethylene or polypropylene, a problem has been confirmed that the volatile drug as the active ingredient is adsorbed on the container side and is not volatilized while being sealed and packaged for a long time. In this case, the actual amount of volatilization is reduced compared to the amount of the drug that should be volatilized originally, and a sufficient effect cannot be exhibited. Then, the proposal about making the container shape | molded with resin with low chemical | medical agent adsorptivity, such as polyester and a polycarbonate, was made (for example, refer patent document 1, patent document 2).

  According to the said proposal, the problem that a volatile chemical | medical agent is adsorb | sucked to a container is solved. However, the chemicals volatilized in the sealed package may accumulate in the package and become saturated. As a result, the drug adheres to the inside of the packaging bag in the form of droplets, the amount of the drug that should be volatilized is lost, and when the consumer opens the drug, the drug sticks to fingers and clothes. . Further, volatile chemicals are generally expensive, and not only the expected sufficient medicinal effect cannot be obtained, but also that the amount of the chemical held in the container is impaired is not preferable from the economical aspect.

  Patent Document 3 proposes a countermeasure technique for the volatile drug droplets. Patent Document 3 discloses a container that adsorbs a drug adsorbing material on the surface of a drug non-adsorbing material so that the volatilized drug is adsorbed to the extent that no condensation occurs in the packaging bag. Thereby, even if it is used after being distributed and stored for a long time, the above-mentioned problem that the volatile drug adheres to clothes or the like is solved, and the efficacy of the drug can be maintained for a long time.

JP-A-2-275805 JP-A-11-187797 Japanese Patent No. 4160844

However, Patent Document 3 focuses only on coping with the generated droplets adsorbed on a drug-adsorbing material, and uses polyethylene, polypropylene, or the like as the drug-adsorbing material. As pointed out at the beginning of the present specification, this polyethylene or the like is not preferable from the economical aspect because the drug once held in the container is not effectively used because it is difficult to release the adsorbed drug. Further, since the container according to Patent Document 3 is formed by pasting materials having different properties on the surface thereof, the structure of the container is complicated, and the manufacturing process becomes complicated.
As described above, conventionally, with respect to containers used for insect repellent and aroma products, filled volatile chemicals are not effectively used, which is uneconomical. In many cases, volatile chemicals use natural materials such as filter paper made of pulp as the drug carrier. However, since the containers are made of plastic, the user must dispose of them separately after use. There are also processing issues.

  Therefore, the purpose of the present invention is to economically utilize the drug without reducing the volatilization amount even if the volatile drug is stored for a long period of time, and to separate it after using the product. Another object of the present invention is to provide a support for a volatile drug, which is a molded article using a material having user-friendly and ecological properties that can be disposed of without waste and having excellent moldability.

  The above object is a support capable of supporting or storing a drug carrier, and the support is obtained by molding a main raw material obtained by kneading paper fibers and a water-soluble polymer binder with water, followed by drying by heating. It is achieved by a support for a volatile drug characterized in that it is a volatile drug (claim 1).

  The main raw material is kneaded by adding 50 to 200 parts of water to a mixture of 50 to 90 parts of the paper fibers and 10 to 50 parts of the water-soluble polymer binder to make 100 parts. The kneaded product is preferably (claim 2).

  More preferably, a non-alkali metal long chain fatty acid salt is further added (Claim 3), and the non-alkali metal long chain fatty acid salt comprises the paper fiber, the water-soluble polymer binder and water. It is desirable that 0.2 to 2.0 parts is added to 100 parts of the kneaded product.

The water-soluble polymer binder may be starch, polyvinyl alcohol (PVA), carboxymethyl cellulose (CMC), or a combination thereof (Claim 5).
Further, the water-soluble polymer binder is preferably formed with starch as a main component (Claim 6), and the water-soluble polymer binder is formed by mixing starch and polyvinyl alcohol. More preferably (Claim 7), the water-soluble polymer binder is preferably mixed with 90 to 50% by weight of starch and 10 to 50% by weight of polyvinyl alcohol (Claim 8).

  And the said volatile chemical | medical agent can be made into a volatile pyrethroid type chemical | medical agent at normal temperature (Claim 9).

Moreover, it is good also as a structure where the support body which carries the said volatile chemical | medical agent is shape | molded integrally with the support body (Claim 10).
And the support body for volatile chemical | medical agents in any one of the said contains the container provided with the space which accommodates the support body of the said volatile chemical | medical agent (Claim 11), The support body which concerns on this invention is You may shape | mold into various shapes.

According to the present invention, once adsorbed to a volatile drug that volatilizes at room temperature, it is volatilized again thereafter, and therefore a support for a volatile drug that can effectively utilize the drug can be provided.
And since the support for volatile chemicals of the present invention is composed of a main raw material obtained by kneading paper fibers and a water-soluble polymer binder with water, unlike a conventional product composed of plastic, it is disposed at the time of disposal. There is no need for separation, and it can be provided as a product with user friendliness and ecology.

Hereinafter, preferred embodiments of the support for a volatile drug according to the present invention will be described.
The support for a volatile drug of the present invention is a structure that supports or houses a drug carrier such as a filter paper carrying a volatile drug, and is capable of adsorbing the volatile drug, and the adsorbed volatile drug. The shape is not limited as long as it has re-volatility that can be volatilized (released) later. That is, the support body for a volatile drug according to the present invention may be, for example, a so-called container having a plate shape, a recessed shape with a dent, and a space for holding and storing the drug carrier inside.
Furthermore, the support body for volatile chemical | medical agents based on this invention may be either the form hold | maintained in direct contact with the support body of a volatile chemical | medical agent, or the form accommodated indirectly.

Hereafter, the support body for volatile chemical | medical agents based on this invention is demonstrated concretely.
The support for a volatile drug of the present invention is a structure that supports or stores a drug carrier such as a filter paper carrying a volatile drug as described above, and is re-volatile when adsorbing the volatile drug. If it has, the shape will not be specifically limited.
This volatile drug support is obtained by heating and drying a main material obtained by kneading paper fibers and a water-soluble polymer binder with water. When drying by heating, it is formed into a desired shape such as a plate shape or a concave shape by using a mold. And since the above main raw materials are heat-dried and solidified, a volatile chemical | medical agent can be adsorb | sucked and the volatile property which makes the adsorbable volatile chemical | medical agent volatilizable later is shown.

  Examples of the paper fiber include pulp for papermaking obtained from wood, cotton, flax, hemp, cocoons, etc., paper such as newspapers, magazines, cardboard, paperboard, cutting waste paper, and waste paper generated in the papermaking process. Waste paper can be used. In particular, those finely pulverized are easily dispersed even when blended as a molding material, and the surface of the molded body is excellent in smoothness, which is particularly preferable.

A water-soluble polymer binder is used as a binder for binding the paper fibers. The water-soluble polymer binder is preferably selected from starch, polyvinyl alcohol (PVA) and carboxymethyl cellulose (CMC), and these can be used alone or in appropriate combination. For example, starch may be used as a main component of the binder, and PVA may be used as a subcomponent to form a mixed polymer binder.
Since starch has a molecular structure that is very similar to paper fibers, paper fibers can be firmly bonded. When the thickness of the support body for volatile chemicals to be produced is thin, warpage is likely to occur. However, the use of starch can improve the strength and rigidity of the structure and suppress warpage.

  Examples of the starch include potato starch, sweet potato starch, tapioca starch, wheat starch, corn starch, rice starch, waxy corn starch, raw starch such as sago starch, and derivatized products such as esterification and etherification. Alternatively, modified starch obtained by alphatizing, oxidizing or positiveizing them can be exemplified. Further, these can be used alone or a mixture of them can be suitably used, but is not limited to the starch exemplified here.

  When starch is employed as the water-soluble polymer binder, it is preferable to mix PVA to form a mixed polymer binder. Although the molecular structure of PVA is different from that of paper fiber and starch, it has a hydrophilic group of the same degree as starch in the molecule, so that it functions to be compatible with starch and bind paper fiber. Furthermore, since PVA is a long chain polymer, it has high toughness, and when mixed with starch, the toughness of the molded support for volatile drugs can be improved. What mixed 90-50 weight% of starch and 10-50 weight% of PVA is preferable. Such a mixed binder (binder) of starch and PVA exhibits excellent toughness. Therefore, when such a mixed binder is used, it is possible to obtain a support for a volatile drug that has toughness and can suppress cracks and the like.

  As long as the polyvinyl alcohol is water or hot water-soluble polyvinyl alcohol, the degree of polymerization and the degree of saponification are not particularly limited, and modified polyvinyl alcohol obtained by cation modification or anion modification thereof can be used. Moreover, these can be used individually or what mixed them can be used, and is not limited to the polyvinyl alcohol illustrated here.

  Further, it is desirable to add a non-alkali metal long-chain fatty acid salt from the viewpoint of improving the processability of the support for volatile chemicals. Examples of such non-alkali metal long chain fatty acid salts include calcium stearate, magnesium stearate, zinc stearate, aluminum stearate, strontium stearate, zinc laurate, aluminum laurate, strontium laurate and the like. These alone or a mixture of them are easily mixed evenly with paper fibers and water-soluble polymer binders, exhibit excellent lubricity in the powder state, lubrication and release due to the active effect at the interface Workability can be improved by the action. Further, by adding the long-chain fatty acid salt of the non-alkali metal, the metal salt of the long-chain fatty acid acts as a release agent, so that the material sticks to the wall surface of the kneader in the step of kneading the material. Can be suppressed and the production efficiency can be improved.

The support for volatile chemicals uses a main raw material obtained by kneading the paper fiber and the water-soluble polymer binder with water. The main raw material is 50 to 90 parts of the paper fiber and the water-soluble polymer bond. It is desirable to use a kneaded product obtained by adding 50 to 200 parts of water and kneading the mixture to 10 parts of 10 to 50 parts of the agent.
If the paper fiber is 50 parts or less and the water-soluble polymer binder is 50 parts or more, the reinforcing effect of the paper fiber is reduced, and a molded article having high mechanical strength cannot be obtained. On the other hand, when the paper fiber is 90 parts or more and the water-soluble polymer binder is less than 10 parts, the water-soluble polymer binder becomes difficult to bind the paper fibers sufficiently, so that the surface of the volatile drug support is rough. At the same time, the mechanical strength is unfavorable.

  In addition, 50 parts to 200 parts of water is added to 100 parts of the mixture of the paper fiber and the water-soluble polymer binder because the binding action of the water-soluble polymer binder is sufficient when the amount of water added is 50 parts or less. It is difficult to make paper fibers into a pellet or flake kneaded product. On the other hand, when the amount of water is 200 parts or more, the viscosity of the kneaded product is remarkably lowered, which is not preferable for use in molding a support for volatile chemicals.

  Furthermore, it is preferable to add 0.2 to 2.0 parts of the non-alkali metal long-chain fatty acid salt to 100 parts of the kneaded product of paper fiber, water-soluble polymer binder and water. When the addition amount of the non-alkali metal long-chain fatty acid salt is 0.2 parts or less, the effect is small, and the material tends to stick to the wall surface of the kneader in the kneading step of the material, so that workability and yield are reduced. On the other hand, when the addition amount of the non-alkali metal long-chain fatty acid salt is 2.0 parts or more, the friction resistance with the kneading machine wall surface is reduced in the kneading step, so that it is difficult to uniformly knead in a short time, which is not preferable. .

A kneaded product obtained by kneading paper fiber and a water-soluble polymer binder used in molding a support for a volatile drug of the present invention with water is, for example, a commercially available molding such as an extrusion molding machine, an injection molding machine, or a press molding machine. It can be molded using a machine.
Hereinafter, the case of extrusion molding will be described. A commercially available extrusion molding machine, for example, a hopper for charging the kneaded material into the molding machine, a screw that is stirred and plasticized while being heated and extruded to the front side of the molding machine, and provided at the front end of the molding machine And a die having a die called a die. The mixture is put into the hopper, extruded from a heated mold, and solidified by further drying.
In the case of injection molding, the plasticized kneaded product is injected into a heated mold, solidified by heating and drying, and formed into a desired shape.

As the volatile chemical used in the present invention, various chemicals can be used as long as they are volatile at room temperature. Examples of highly volatile chemicals include chemicals having a vapor pressure of 1 Pa or higher at 25 ° C., for example, organic compounds such as toluene (3.8 kPa), ethyl alcohol (5.9 kPa), and isopropyl alcohol (4.4 kPa). Natural fragrances such as solvents, grapefruit oil, rose oil, fine oil, synthetic fragrances such as limonene (0.18 kPa), menthol, citronell, jasmine, pentalide, and blended fragrances prepared from them are used.
Examples of low volatility drugs include drugs having a vapor pressure of less than 1 Pa at 25 ° C., for example, metfurthrin (1.96 mPa), profluthrin (10.0 mPa), phthalthrin, resmethrin, permethrin, cypermethrin, phenothrin, Cifenotrin, empentrin, praretrin, allethrin, terrareslin, miprothrin, imiprothrin, transfluthrin, fenfluthrin, fenpropatorin, 2,3,5,6-tetrafluoro-4-methylbenzyl (1R) -trans-3- Pyrethroid insecticides such as (2-chloro-2-fluorovinyl) -2,2-dimethylcyclopropanecarboxylate are preferably used.

Below, the Example which manufactured the support body for volatile chemical | medical agents and applied to the volatile chemical | medical agent is described.
Prepare the pyrethroid drug profluthrin used as an insect repellent as a low volatile organic solvent at room temperature, and toluene as a highly volatile organic solvent. The drug residual ratios in the samples after the passage of time were compared.

Example 1
A kneaded material was prepared by adding 60 parts of paper fiber, 30 parts of corn starch and 10 parts of PVA as a water-soluble polymer binder, 0.5 part of a non-alkali metal long-chain fatty acid salt, and 60 parts of water. This kneaded product was injection-molded to obtain a flat plate (thickness 1 mm) that was to be a support for volatile chemicals in the examples. This flat plate was made into a sample of 100 mm × 100 mm square. In addition, filter paper (hereinafter referred to as drug-impregnated filter paper) serving as a carrier for volatile chemicals taken out from commercially available insect-proof products (insect-proof products manufactured by Hakugen Co., Ltd., drugs / profluthrin in Mrs Lloyd (registered trademark)) Got ready. A PET / PE film (Torphan (registered trademark) manufactured by Toray Industries, Inc.) with a 100-mesh metal net sandwiched between the volatile drug support of the example and the drug-impregnated filter paper. And sealed. The package was allowed to stand in a constant temperature layer at 40 ° C. for 1 month, and an environment for long-term storage was set such that the chemical volatilized from the chemical-impregnated filter paper was adsorbed on the sample.

(Comparative Example 1)
A sample for comparison of 100 mm × 100 mm square taken from a commercially available polypropylene flat plate (thickness 0.7 mm) was prepared. Others were the same as in Example 1 above.

(Example 2)
The flat plate produced in Example 1 was produced into a 30 mm × 50 mm square sample. This sample was adsorbed by immersion for 10 minutes in toluene, which is a highly volatile organic compound, prepared as a volatile chemical.

(Comparative Example 2)
A 30 mm × 50 mm square sample taken from a commercially available polypropylene flat plate (thickness 0.7 mm) was prepared as a comparative sample. Others were the same as in Example 2 above.
(Comparative Example 3)
A 30 mm × 50 mm square sample taken from a commercially available polypropylene flat plate (thickness 0.7 mm) was prepared as a comparative sample. The conditions other than the immersion in toluene for 24 hours were the same as in Example 2 above.

The sample which adsorb | sucked the volatile chemical | medical agent described in Examples 1 and 2 and Comparative Examples 1-3 was left to stand at 23 degreeC and 50% of constant room conditions, and the re-volatilization of the chemical | medical agent was measured from the weight change. The results are shown below.
In addition, since the sample is assumed to have a weight change due to moisture absorption and desorption of moisture in the air, a blank sample that does not adsorb a volatile chemical was prepared, and the weight of the test sample was corrected using the weight change.
The results are shown in Table 1 and Table 2.

  From the test results shown in Table 1 above, the polypropylene of Comparative Example 1 shows a high adsorption amount and a residual ratio of chemicals (90% or more) with respect to profluthrin, which is a low volatility drug, whereas the volatility of Example 1 According to the drug support, initial adsorption occurs, but after a certain period of time, the drug remaining rate is 6.7%, and more than 93% of the drug adsorbed in the initial stage has been re-volatilized, and the drug is effectively utilized. That is confirmed.

  According to the test results shown in Table 2, the polypropylenes of Comparative Examples 2 and 3 showed a high chemical residual ratio with respect to toluene, which is a highly volatile organic solvent, whereas according to the support for volatile chemicals of Example 2, Although the initial adsorption occurs, the residual rate of chemicals after 3.5 hours is 2.5%, and more than 97% of the drug adsorbed in the initial stage has been re-volatilized, confirming that the drug is being used effectively. The

As described above, the support for a volatile drug according to the present invention has a volatile drug once adsorbed to a low-volatile or high-volatile volatile drug at room temperature, Since it is volatilized, the drug can be used effectively. As a result, when the support for a volatile drug of the present invention is stored for a long time in a sealed package together with the volatile drug and the drug is volatilized, the drug droplets adhere to the packaging film because it is once adsorbed. The situation can be suppressed. And since a chemical | medical agent volatilizes again at the time of the use which the package was opened after that, it becomes possible to acquire the chemical | medical agent effect which expected the effective utilization of a chemical | medical agent.
Furthermore, since the support for a volatile drug of the present invention comprises a main raw material in which paper fibers and a water-soluble polymer binder are kneaded with water, unlike a product composed of conventional plastics, it is discarded. In this case, the product can be provided as a product having user friendliness and ecology.

Although the description of the embodiment has been completed above, the present invention is not limited to the above-described embodiment, and it is needless to say that various modifications can be made without departing from the scope of the invention.
In the above-described embodiments, the case where the support for the volatile drug is a simple plate has been described as an example, but the form of the support for the volatile drug of the present invention is not particularly limited. That is, what is necessary is just to shape | mold into various shapes according to the request | requirements, such as a flat plate shape, a bowl shape, and what is called a container shape provided with a storage space, for the product design according to a market. Even when the support for volatile chemicals of the present invention is used as a container having a storage space therein, the kneaded material is injected into a mold in which a cavity for the container is formed, according to the above-described embodiment. And then molding.

  In the volatile drug support according to the present invention, a sheet (filter paper or the like) serving as a drug carrier can be placed in a predetermined position in the mold and insert-molded. Therefore, it is possible to manufacture a structure in which the drug carrier and the drug storage container are integrated, which is difficult with the conventional drug storage container. Then, the manufactured drug carrier of the integrated container may be impregnated later with a volatile drug to form an insect repellent / fragrance product.

Claims (11)

A support capable of supporting or storing a volatile drug carrier,
A support for a volatile drug, wherein the support is obtained by molding a main raw material obtained by kneading paper fiber and a water-soluble polymer binder with water and drying by heating.   The main raw material is kneaded by adding 50 to 200 parts of water and kneading to 100 parts by adding 50 to 90 parts of the paper fibers and 10 to 50 parts of the water-soluble polymer binder. It is a thing, The support body for volatile chemical | medical agents of Claim 1 characterized by the above-mentioned.   The support for a volatile drug according to claim 2, further comprising a non-alkali metal long-chain fatty acid salt added thereto.   The non-alkali metal long-chain fatty acid salt is added in an amount of 0.2 to 2.0 parts with respect to 100 parts of a kneaded product of the paper fiber, the water-soluble polymer binder and water. The volatile drug support according to claim 3, wherein the support is a volatile drug.   The volatile drug support according to any one of claims 1 to 4, wherein the water-soluble polymer binder is any one of starch, polyvinyl alcohol, carboxymethyl cellulose, or a combination thereof.   The volatile drug support according to claim 5, wherein the water-soluble polymer binder is formed with starch as a main component.   The support for a volatile drug according to claim 6, wherein the water-soluble polymer binder is formed by mixing starch and polyvinyl alcohol.   The volatile drug support according to claim 7, wherein the water-soluble polymer binder is a mixture of 90 to 50% by weight of starch and 10 to 50% by weight of polyvinyl alcohol.   The volatile drug support according to any one of claims 1 to 8, wherein the volatile drug is a pyrethroid drug that is volatile at room temperature.   The support body for a volatile drug according to any one of claims 1 to 7, wherein the carrier for supporting the volatile drug is formed integrally with the support body.   The volatile drug support according to claim 1, wherein the volatile drug support includes a container having a space for storing the volatile drug carrier.