JP2010236943A - Blood sugar level measuring device, blood sugar level measuring method, and program - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To combine automatically a timing when a user measures a blood sugar level with measurement data. <P>SOLUTION: A blood sugar level measuring device 1 includes: a chip discrimination part 31 for discriminating presence/absence of mounting of a first or second chip having a prescribed portion for storing blood, and the kind of the mounted first or second chip; a blood sugar level measuring part 32 for discriminating whether a timing for measuring blood adhering onto the prescribed portion is after the meal of the user or not, according to the kind of the first or second chip discriminated by the chip discrimination part 31, and analyzing the blood adhering onto the prescribed portion, to thereby measure the blood sugar level; and a storage part for storing the measured blood sugar level together with information on the timing when the blood sugar level is measured. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

  The present invention relates to a blood sugar level measuring device, a blood sugar level measuring method, and a program used for measuring a blood sugar level in blood.

  Conventionally, a blood glucose level measuring device (simple self blood glucose measuring device) in which a user himself / herself measures a blood glucose level in blood using a portable blood glucose level measuring device for diagnosis, treatment and medical guidance of diabetes is known. It has been. For example, the blood glucose level measuring apparatus optically measures (colorimetry) the degree of color development of a test paper that develops color according to the amount of glucose in the blood, and quantifies the blood glucose level. Patent Document 1 discloses a technique for calculating a blood sugar level in blood by measuring the intensity of reflected light obtained by irradiating light onto a reagent piece to which blood has adhered.

  The conventional blood glucose level measuring device is highly convenient because the user can measure the blood glucose level under the guidance of a doctor or a diabetes medical instructor.

JP 2000-46834 A

  By the way, blood sugar level in blood changes in daily life. It is known that the amount of change in blood sugar level is particularly large before and after a meal.

  It is generally known that the blood sugar level continues to decrease until the user starts eating, but the blood sugar level rapidly increases after the meal. This postprandial blood glucose level is an important indicator for preventing diabetic complications and determining an appropriate dose of insulin.

  However, if it is determined whether or not the timing at which the blood glucose level is measured is after a meal, the doctor can provide appropriate guidance to the user, but conventionally the timing at which the user has measured the blood glucose level is after the meal. Whether or not it was only estimated by the measurement time.

  In addition, a function of marking measurement after a meal by some operation such as button operation of a blood glucose level measurement device or insertion / extraction of a measurement chip is known. However, forgetting to press the button, for example, there will be a situation where the operation itself is forgotten and cannot be marked.

  The present invention has been made in view of such a situation, and an object thereof is to automatically associate and store the blood glucose level measured after a meal as data measured after the meal.

In the present invention, first, the presence or absence of the first or second chip having a predetermined part for containing blood and the type of the first or second chip mounted are identified.
Next, according to the type of the identified first or second chip, it is identified whether or not the timing of measuring the blood stored in the predetermined part is after the user's meal, and the blood attached to the predetermined part Measure blood glucose levels.
And the measured blood glucose level is memorize | stored with the information regarding the timing when a blood glucose level is measured.

  By doing in this way, the timing when a blood glucose level is measured can be identified according to the kind of the 1st or 2nd chip with which it was equipped.

  According to the present invention, the type of the chip is identified, the timing at which the blood glucose level is measured is identified according to the type of the chip, and the measured blood glucose level is stored together with the information on the timing at which the blood glucose level is measured. it can. For this reason, there is an effect that it becomes easy to determine at which timing the blood glucose level read from the storage unit is measured.

It is an external appearance perspective view which shows the example of the blood glucose level measuring device in the 1st Embodiment of this invention. It is an external appearance perspective view which shows the example of the chip | tip in the 1st Embodiment of this invention. It is a block diagram which shows the cross-sectional example of the blood glucose level measuring apparatus along the AA 'line of FIG. 1 in the 1st Embodiment of this invention. It is a block diagram which shows the example of an internal structure of the blood glucose level measuring apparatus in the 1st Embodiment of this invention. It is a block diagram which shows the example of an internal structure of the control part in the 1st Embodiment of this invention. It is explanatory drawing which shows the example of the range which measures the received light quantity and blood glucose level of the light ray which the conventional test paper reflects. It is explanatory drawing which shows the example of the range which measures the received light quantity and blood glucose level of the light beam which the test paper reflects in the 1st Embodiment of this invention. It is a flowchart which shows the operation example in the 1st Embodiment of this invention until a user measures a blood glucose level using a blood glucose level measuring apparatus. It is explanatory drawing which shows the example of each status displayed on the display part in the 1st Embodiment of this invention. It is explanatory drawing which shows the internal structural example of the chip | tip in the 2nd Embodiment of this invention. It is a block diagram which shows the example of an internal structure of the blood glucose level measuring apparatus in the 2nd Embodiment of this invention. It is a block diagram which shows the example of an internal structure of the control part in the 2nd Embodiment of this invention. It is explanatory drawing which shows the example of the electric current value used in order to identify the kind of chip | tip in the 2nd Embodiment of this invention. It is explanatory drawing which shows the internal structural example of the chip | tip in the 3rd Embodiment of this invention. It is a block diagram which shows the example of an internal structure of the control part in the 3rd Embodiment of this invention.

<1. First Embodiment>
Hereinafter, a first embodiment of the present invention will be described with reference to FIGS. In the present embodiment, the difference in the amount of reflected light for each chip is used to identify whether or not the timing at which the blood sugar level is measured is after a meal (for example, between 30 minutes and 2 hours after a meal). An example of the attached optical blood glucose level measuring apparatus 1 will be described.

FIG. 1 shows an external perspective view of a blood sugar level measuring apparatus 1.
The blood glucose level measuring apparatus 1 includes a display unit 2 for displaying various information, a power button 3 for switching on / off of power, and a past history of blood glucose levels stored in a data storage unit 24 (see FIG. 4 described later). Is displayed on the display unit 2.

  Further, the blood glucose level measuring apparatus 1 removes the holder 7 from which the first tip 10a or the second chip 10b is attached and detached, and the first chip 10a or the second chip 10b attached to the holder 7. An ejector 6 is provided. In addition, the blood sugar level measuring apparatus 1 includes a housing 5 in which each part is arranged. A printed circuit board (not shown) is disposed inside the housing 5 and performs predetermined calculation and blood glucose level measurement processing.

  In this example, the post-meal measuring chip that is mounted after meal is the first chip 10a, and the chip that is mounted after non-meal is the second chip 10b. Hereinafter, the first chip 10a or the second chip 10b may be simply referred to as “chip”.

  The first chip 10a and the second chip 10b are stored in separate cases 11, and are kept in a sanitary and dry state without touching the outside air until the blood glucose level is measured. Different test papers 13a and 13b (see FIG. 2 to be described later) for each type of chip are fitted inside the chip. Hereinafter, the test papers 13a and 13b may be simply referred to as “test paper”.

  When blood adheres to the test paper, a chemical reaction occurs and the test paper develops color. The blood sugar level measuring apparatus 1 measures the blood sugar level by irradiating the part where the test paper develops a light beam and measuring the amount of light received by the light beam reflected by this part. The case 11, the first chip 10a, and the second chip 10b have different external identification information when viewed from the outside. The external identification information includes at least one information of color, shape, and display. The user can prevent the mistake of the chip by the external identification information.

FIG. 2 shows an example of an external perspective view of the first chip 10a and the second chip 10b.
The first chip 10a includes a test paper 13a and four protrusions 14a to 14d formed around the test paper 13a. The protrusions 14a to 14d are fitted into the holder 7 and have a function of fixing the first chip 10a to the holder 7 and blocking incident light from the outside.

  The second chip 10b has substantially the same shape as the first chip 10a, but differs in configuration in that it includes a test paper 13b having a color different from that of the test paper 13a.

  FIG. 3 shows an example of the configuration of the holder 7 and the chip in a cross-sectional view taken along the line AA ′ in FIG.

The blood sugar level measuring apparatus 1 includes a light emitting unit 15 that emits a light beam having a predetermined wavelength with respect to a test paper, and a light receiving unit 16 that receives the light beam and generates a light reception signal.
The chip includes a capillary tube 12 that sucks blood adhering to the tip by capillary action, and a test paper into which the blood sucked through the capillary tube 12 penetrates.

  For the light emitting unit 15, for example, a light emitting diode that emits light having a wavelength of 630 nm is used. For the light receiving unit 16, for example, a photodetector is used.

  When the chip is attached to the holder 7, the light receiving unit 16 receives the light beam reflected from the test paper and generates a light reception signal. On the other hand, when a chip is not attached to the holder 7, light from the external environment is received and a light reception signal is generated. The amount of light received by the light receiving unit 16 is calculated by the chip identification unit 31 (see FIG. 5 described later) based on the light reception signal generated by the light receiving unit 16.

  The tip and the thin tube 12 are made of a rigid material having a predetermined rigidity. Examples of such a rigid material include acrylic resin, polystyrene, polyethylene, polypropylene, hard polyvinyl chloride, polycarbonate, polymethyl methacrylate, ABS resin, polyester, polyphenylene sulfide (PPS), polyamide, polyimide, polyacetal, and the like. Various resin materials such as polymer alloys and polymer blends containing one or more of them can be mentioned. Of these, highly hydrophilic materials such as acrylic resins or those that have been hydrophilized are particularly suitable for rapid introduction and development of specimens.

  Examples of the hydrophilization treatment include physical activation treatment such as plasma treatment, glow discharge, corona discharge, and ultraviolet irradiation, and addition (application) of a surfactant, water-soluble silicon, hydroxypropylcellulose, polyethylene glycol, polypropylene glycol, and the like. Etc.

  The test paper is obtained by carrying (impregnating) a reagent (coloring reagent) on a carrier capable of absorbing blood (specimen). This carrier is preferably composed of a porous membrane (sheet-like porous substrate). In this case, the porous membrane preferably has a pore size that can filter out red blood cells in blood.

  By using a porous membrane carrier, when the reagent to be impregnated is a reagent system that includes a process of reacting with oxygen as a substrate, such as an oxidase reaction, the blood receiving side is covered with blood after spreading on the test paper. Even in this state, oxygen in the atmosphere is supplied from the reaction side (opposite surface), so that the reaction can be rapidly advanced, and thus the color development state can be detected without removing blood.

Examples of the test paper carrier include, in addition to the porous membrane, a sheet-like porous substrate such as a nonwoven fabric, a woven fabric, and a stretched sheet.
Examples of the constituent material of the carrier such as the porous membrane include polyesters, polyamides, polyolefins, polysulfones, and celluloses, but it is impregnated with an aqueous solution in which a reagent is dissolved. In order to perform rapid development, a hydrophilic material or a material that has been subjected to a hydrophilic treatment is preferable. Examples of the hydrophilic treatment include the same methods as described above.

  Examples of the reagent impregnating the carrier (porous membrane) include glucose oxidase (GOD), peroxidase (POD), 4-aminoantipyrine (4-AA), and N-ethyl-N- (2-hydroxy-3). And a color former (coloring reagent) such as -sulfopropyl) -m-toluidine (TOOS). Furthermore, a buffering agent such as a phosphate buffer may be included. Needless to say, the types and components of the reagents are not limited to these.

  Next, an example of the internal configuration of the blood sugar level measuring apparatus 1 will be described with reference to FIGS. 4 and 5.

FIG. 4 shows an example of the internal configuration of the blood sugar level measuring apparatus 1.
In addition to the display unit 2, the light emitting unit 15, and the light receiving unit 16, the blood glucose level measuring device 1 includes an A / D conversion unit 17 that converts a light reception signal generated by the light receiving unit 16 into digital data, and a control unit that controls each unit. 21, a control oscillation unit 22, a clock oscillation unit 23, a data storage unit 24, an external output unit 25, a power supply 26, a power supply voltage detection unit 27, an operation unit 28, and a buzzer output unit 29.

  A printed circuit board provided inside the housing 5 is equipped with a control unit 21 configured by a microcomputer (MPU: Micro Processing Unit), and controls various operations of the blood sugar level measuring apparatus 1. The control unit 21 includes a calculation unit that calculates a target blood component (glucose) based on a signal from the light receiving unit 16. This computing unit also performs, for example, hematocrit value correction calculation as necessary.

  The light emitting unit 15 and the light receiving unit 16 are housed and held in the holder 7. The light emitting unit 15 is electrically connected to the control unit 21, and the light receiving unit 16 is electrically connected to the control unit 21 via an amplifier and an A / D conversion unit 17 (not shown).

  The light emitting unit 15 is activated by a signal from the control unit 21 and emits pulsed light at a predetermined time interval. For example, the period of the pulsed light is about 0.5 to 3.0 msec, and the emission time of one pulse is about 0.05 to 0.3 msec. The wavelength of the pulsed light is preferably about 500 to 720 nm, more preferably about 580 to 650 nm.

  A tip is detachably attached to the tip of the holder 7. When the chip is mounted on the holder 7, the tip surface of the holder 7 faces the test paper provided on the chip. In this state, the light emitted from the light emitting unit 15 is applied to the test paper, and the reflected light reflected by the test paper is received by the light receiving unit 16 and subjected to photoelectric conversion. The light receiving unit 16 outputs an analog signal corresponding to the amount of received light and amplifies it to a desired value. Thereafter, the analog signal is converted into a digital signal by the A / D converter 17 and input to the controller 21.

  The control oscillating unit 22 constitutes a timer, oscillates a clock pulse at a constant time interval, and supplies a reference signal for operation of the microcomputer of the control unit 21.

  The clock oscillating unit 23 constitutes a clock that specifies absolute time (date and time), oscillates clock pulses at regular time intervals, and supplies a reference signal for operation of the clock control circuit built in the control unit 21.

The data storage unit 24 includes a first memory (RAM) (not shown), a second memory (ROM), and a third memory (nonvolatile RAM) that is a rewritable nonvolatile memory.
In the first memory, the received light amount data input from the light receiving unit 16 is stored in accordance with a predetermined format.
In the second memory, the relationship (calibration curve) between the absorbance obtained from the photometric value and the target blood glucose level is stored in a table in advance, and each threshold value is also stored. .
In the third memory, a calibration value unique to each device is stored in advance. Specific calibration values referred to here include, for example, a prescribed value of the amount of received light, a correction coefficient for absorbance calculation, and the like. Further, the measured blood glucose level is stored in the third memory.

  The external output unit 25 outputs the obtained blood glucose level data to an external device such as a personal computer. For this reason, the external output unit 25 incorporates a communication driver such as RS-232C. In addition, when performing infrared communication, the external output unit 25 incorporates an infrared light emitting element and its drive circuit.

  As the power source 26, a battery (not shown) is loaded inside the housing 5. The power supply 26 supplies power to each block provided in the blood sugar level measuring apparatus 1. The power supply voltage detection unit 27 detects the voltage of the battery and outputs the detected voltage value (detection value) to the control unit 21. Thereby, the remaining amount of the battery can be checked.

  The operation unit 28 is a general term for the power button 3, the call button 4, and the like described above. The operation unit 28 detects inputs of various switches as described below, and inputs the signals to the control unit 21. Examples of the switch include a power switch, a measurement switch, a call switch, a stored data read switch, a time setting / change switch, a reset switch, a buzzer operation / non-operation selection switch, and a 50 Hz / 60 Hz commercial power frequency selection switch. The power switch can be turned on / off by pressing the power button 3.

  The buzzer output unit 29 operates the buzzer based on a signal from the control unit 21 and emits a sound.

FIG. 5 shows an internal configuration example of the control unit 21.
The control unit 21 measured whether or not a chip was mounted on the holder 7, a chip identification unit 31 for identifying the type of chip mounted on the holder 7, and a chip mounted on the holder 7. A blood glucose level measurement unit 32 that measures a blood glucose level based on the amount of received light is provided.

First, the chip identification unit 31 measures the amount of received light based on the light reception signal supplied from the light receiving unit 16 via the A / D conversion unit 17.
Next, the chip identification unit 31 identifies the presence / absence of a chip mounted and the type of chip mounted based on the amount of received light.

  And the blood glucose level measurement part 32 measures the blood glucose level of the blood adhering to the predetermined site | part of a chip | tip based on the measured received light quantity. At this time, since the chip identification unit 31 identifies the type of the chip in advance, it is possible to identify whether or not the timing when the blood glucose level is measured is after the user's meal. Thereafter, the blood glucose level measurement unit 32 stores the measured blood glucose level in the third memory together with information regarding the measurement date and time of the blood glucose level and the timing at which the blood glucose level was measured.

Next, the relationship between the test paper and the amount of received light will be described.
FIG. 6 shows an example of the range in which the received light quantity of the light beam reflected by the conventional test paper 13b and the blood glucose level are measured.

  When the second chip 10b is mounted on the holder 7 and the light emitting unit 15 irradiates the test paper 13b with light, the test paper 13b reflects the light. When blood does not adhere to the test paper 13b, the amount of received light is large as shown in the region 41. This is because, for example, when the test paper 13b to which no blood is attached is white, the light reflectance is high.

  On the other hand, immediately after the blood soaks into the test paper 13b, the test paper 13b is colored in the color of blood, and a part of the light beam irradiated by the light emitting unit 15 is absorbed by the test paper 13b. For this reason, as shown in the region 42, the amount of received light is reduced. At this time, the blood sugar level measuring unit 32 does not measure the blood sugar level.

  Thereafter, the color reagent preliminarily soaked in the test paper 13b dissolves in the blood soaked in the test paper 13b, and reacts with glucose in the blood to produce a dye corresponding to the amount of glucose in the blood on the test paper 13b. The The amount of received light obtained by irradiating the test paper 13b with light is smaller than that immediately after blood has soaked into the test paper 13b, as indicated by a region 43. For this reason, the blood glucose level measuring unit 32 can measure the blood glucose level in the blood by measuring the amount of received light obtained by irradiating the test paper on which the pigment is generated with light.

<Coloring of test paper>
Here, a mechanism for coloring when blood adheres to the test paper will be described.
In this example, the glucose oxidase / peroxidase (GOD / POD) method is used to develop the test paper.

First, glucose is converted into hydrogen peroxide and gluconic acid by the action of GOD.
Glucose + O ₂ + H ₂ O → Gluconic acid + H ₂ O ₂ (1)

Next, the chromogen (for example, 4-AA and TOOS) in the reaction reagent reacts with hydrogen peroxide by the action of POD to produce a quinone dye.
H ₂ O ₂ + chromogen → quinone dye (oxidation / color development) (2)

  At this time, the light emitting unit 15 irradiates the test paper including the generated pigment with light, and the light receiving unit 16 receives the reflected light of the light reflected from the test paper. And the blood glucose level measurement part 32 measures the blood glucose level in the blood based on the measured received light quantity.

  The blood sugar level measuring apparatus 1 of the present example reliably detects that the first chip 10a dedicated for after meal is attached to the holder 7 in order to identify whether or not the timing when the user measured the blood sugar level is after meal. There is a need to. Therefore, by changing the detection range of the amount of received light as follows, the type of the first chip 10a or the second chip 10b can be identified by simply updating the software without adding hardware. did.

  FIG. 7 shows an example of the range in which the amount of received light and the blood sugar level of the light beam reflected by the test papers 13a and 13b are measured.

  The blood glucose level measuring apparatus 1 obtains information on whether or not the timing of measuring the blood glucose level is after a meal, in addition to the second chip 10b that has been conventionally used for measuring the blood sugar level, In order to measure the value, the first chip 10a is prepared. Here, when there is no blood adhering to the test paper 13b, the amount of received light is large as shown in the region 45, but the test paper 13a is lightly colored. The amount of received light is smaller than that of the paper 13b.

  As described above, when blood is not attached to predetermined portions (in this example, the test papers 13a and 13b) of the first chip 10a and the second chip 10b, the amount of received light measured by the chip identification unit 31 is They are different from each other, and are outside the range in which the blood sugar level measuring unit 32 measures the blood sugar level. For this reason, the chip identifying unit 31 can identify the type of the chip based on the amount of received light when blood is not attached.

  Here, when blood soaks into the test paper, the amount of received light decreases as shown in region 47. When a predetermined amount of blood has soaked into the test paper, the reaction between the glucose in the blood and the coloring reagent soaked in the test paper begins, and as shown in region 48, the blood glucose level is adjusted. A quantity of dye is produced. The blood sugar level measuring apparatus 1 can measure the blood sugar level in the blood by measuring the amount of received light shown in the region 48.

  By the way, when the chip is not attached to the holder 7, the light receiving unit 16 receives light from the external environment and generates a light reception signal. At this time, since the amount of received light is the smallest as shown in the region 49, the chip identifying unit 31 can determine whether or not the chip is mounted.

  FIG. 8 shows an operation example until the user measures the blood sugar level in the blood using the blood sugar level measuring apparatus 1.

  First, the user turns on the power by holding the blood glucose level measuring device 1 and causes the light emitting unit 15 to emit light (step S1). Next, the user determines whether or not the timing for measuring the blood glucose level is after a meal (step S2).

  When the measurement timing is not after meal, the second chip 10b (normal chip) is selected (step S3). On the other hand, if the measurement timing is after meal, the first chip 10a for meal (dedicated post-meal chip) is selected (step S4). Then, the user attaches the selected chip to the holder 7 (step S5).

  The blood sugar level measuring apparatus 1 irradiates light from the light emitting unit 15 onto a test paper to which no blood is attached. Then, the blood sugar level measuring apparatus 1 causes the light receiving unit 16 to receive the light beam reflected from the test paper and supplies the received light amount data to the control unit 21. The control unit 21 causes the chip identification unit 31 to identify the type of chip mounted on the holder 7 based on the received light amount data, and causes the display unit 2 to display the identified chip type (step S6).

  After confirming the type of the chip displayed on the display unit 2, the user soaks his blood into the test paper in the chip. The blood sugar level measuring apparatus 1 obtains a received light quantity by irradiating a test paper in which blood has permeated with a light beam from the light emitting unit 15 and causing the light receiving unit 16 to receive the reflected light beam. Then, the control unit 21 causes the blood glucose level measurement unit 32 to measure the blood glucose level. Thereafter, the control unit 21 stores the measured blood sugar level in the third memory.

  When the blood glucose level measurement is completed, the user removes the first chip 10a or the second chip 10b from the holder 7 (step S8), and ends the measurement operation.

FIG. 9 shows an example of each status displayed on the display unit 2.
The display unit 2 has a function of displaying the type of chip identified by the chip identification unit 31. In step S <b> 1 of FIG. 8, when the user presses the power button 3, the blood glucose level measuring device 1 enters a standby state, and an image 51 that prompts the user to attach the chip to the holder 7 is displayed.

  When the chip is mounted on the holder 7, the chip type is identified, and the identified chip type is displayed. When the second chip 10b is mounted, an image 52a including a message prompting to “add blood” to the chip is displayed together with “OK” indicating that the second chip 10b is correctly mounted. When the chip 10a is mounted, an image 52b including a message indicating “after meal” is displayed in addition to this message.

  While the blood glucose level measurement unit 32 measures the blood glucose level in step S7, an image 53a including a message indicating “under measurement” is displayed. When the first chip 10a is attached, an image 53b including a message indicating “after meal” is displayed in addition to this message.

  When the blood glucose level measurement process performed by the blood glucose level measurement unit 32 is finished, an image 54a including the measurement result is displayed. When the first chip 10a is mounted, an image 54b including a message indicating “after meal” is displayed in addition to the measurement result.

  The measurement result is automatically stored in the data storage unit 24. However, if the user presses the call button 4, the measurement result of the blood glucose level stored in the data storage unit 24 is called at an arbitrary timing, and the measurement time is set. An image 55a including a message indicating the measurement result is displayed. When the measurement result of the blood sugar level measured using the first chip 10a is called, in addition to the measurement result included in the image 55a, an image 55b including a message indicating “after meal” is displayed.

  According to the blood sugar level measuring apparatus 1 according to the first embodiment described above, the type of the chip selected at the timing when the user measures the blood sugar level is automatically identified when the chip is attached to the holder 7. . Further, since the chip identification unit 31 obtains the amount of light received by the light receiving unit 16, it is easy to identify whether or not the chip is mounted. And since the chip type identified by the chip identification unit 31 according to the amount of received light is displayed on the display unit 2, the user can reconfirm the type of chip mounted on the holder 7, There is an effect that deficiencies in data can be reduced.

  Further, since the housing 5 does not have a button or the like for marking that the blood sugar level has been measured after a meal, there is no mark leakage due to an operation mistake such as a user forgetting to press. This has the effect of improving the reliability of the stored data.

  Further, the amounts of received light when blood is not attached to a predetermined part of the chip are different from each other, and are outside the range in which the blood sugar level measuring unit measures the blood sugar level. The amount of received light when blood is not attached to the test paper 13a falls between the amount of received light when no blood is attached to the test paper 13b and the amount of received light immediately after blood has soaked into the test paper. Thus, the material of the test paper 13a was selected. As a result, it is possible to use the post-meal test paper 13a only by updating the software program in the control unit 21 while using the conventional test paper 13b. For this reason, the manufacturing cost is reduced and the maintainability of the software is improved. Moreover, since it is not necessary to add a new member with respect to the conventional blood glucose level measuring apparatus 1, the current size of the apparatus main body can be maintained, and there is an effect that the market advantage is increased.

  In addition, when measuring the blood glucose level, the blood glucose level measuring apparatus 1 stores in the data storage unit 24, as one data set, information on whether or not the measurement was performed after meals, along with information on the blood glucose level and the measurement time. And in a medical institution, when examining diabetes, the past blood glucose level can be called from the data storage part 24, and can be used as an aid of diabetes medical care. Moreover, appropriate guidance from the doctor to the patient can be performed from the post-meal measurement data.

  The case 11 and the chip are provided with different external identification information when viewed from the outside. For this reason, it becomes easy for the user to identify the type of the chip only by grasping the external identification information, and there is no possibility of erroneous mounting on the holder 7. For example, if the color of the case 11 or the chip is changed, and the characters “after meal” are printed, the identification is assured.

<2. Second Embodiment>
Next, a second embodiment of the present invention will be described with reference to FIGS.
In the present embodiment, an example of an electrode-type blood glucose level measuring device 70 that identifies whether or not the timing when the user measured the blood glucose level is after meals based on the difference in the current value of each chip, and links the result to the measurement result will be described. . In the following description, parts corresponding to those in FIG. 4 already described in the first embodiment are denoted by the same reference numerals, and detailed description thereof is omitted.

FIG. 10 shows an example of the internal configuration of the chip.
The first chip 60a for post-meal measurement mounted after the user's meal includes an electrode system including electrode pairs 61 and 62, a sensor unit 64 (accommodating unit) including a portion to which blood adheres, and electrode pairs 61 and 62. Are connected with a predetermined resistance value. The electrode pair 61, 62 is connected to the sensor unit 64, and when blood is attached and becomes conductive, the first resistor 63a and the sensor unit 64 are connected in parallel. The electrode pair 61 and 62 is energized from the power supply 26 via the control unit 21.

  The second chip 60b mounted other than after the user's meal includes the electrode pairs 61 and 62 and the sensor unit 64 described above, and includes a second resistor 63b instead of the first resistor 63a. The resistance value of the second resistor 63b is different from the resistance value of the first resistor 63a. Hereinafter, the first chip 60a or the second chip 60b may be simply referred to as “chip”.

FIG. 11 shows an example of the internal configuration of the blood sugar level measuring apparatus 70.
The blood glucose level measuring device 70 includes a control unit 74 that controls each unit, an I / V conversion unit 71 that converts an analog current value supplied from the sensor unit 64 into an analog voltage value, and amplification that amplifies the converted analog voltage value. And an A / D converter 73 that converts the amplified analog voltage value into digital data and supplies the digital data to the controller 74.

  When a chip is mounted on a holder having a connection terminal corresponding to the electrode pair 61, 62 (a portion corresponding to the holder 7 in the first embodiment described above), a current flows through the electrode pair 61, 62. Then, the I / V conversion unit 71 acquires a current value obtained from the sensor unit 64 via the first resistor 63a or the second resistor 63b. Then, the control unit 74 obtains digital data of the voltage value via the I / V conversion unit 71, the amplification unit 72, and the A / D conversion unit 73, and identifies the type of chip mounted on the holder.

FIG. 12 shows an internal configuration example of the control unit 74.
Based on the digital data of the voltage value acquired from the A / D conversion unit 73, the control unit 74 is configured to detect whether or not the chip is mounted, a chip identification unit 75 that identifies the type of the chip, and blood that has adhered to the sensor unit 64. A blood glucose level measuring unit 76 for measuring the blood glucose level is provided.

The chip identification unit 75 identifies the presence / absence of a chip mounted and the type of the mounted chip based on the current value obtained by energizing the electrode pairs 61 and 62.
The blood glucose level measurement unit 76 obtains the current value of the current supplied to the sensor unit 64 from the digital data of the voltage value. And the blood glucose level measurement part 76 measures the blood glucose level of the blood adhering to the sensor part 64, and memorize | stores the blood glucose level measured with the measurement time in the 3rd memory.

FIG. 13 shows an example of a current value referred to identify the chip type.
When the chip is not attached to the holder, the control unit 74 always detects a current value of 0 ampere as shown in the region 76. For this reason, the chip identification part 75 can identify that the chip is not attached to the holder.

  On the other hand, when the first chip 60a is mounted on the holder, as shown in the region 77, a slight current flows through the first resistor 63a. At this time, the control unit 74 can determine that the first chip 60a is attached to the holder by converting the current value detected by the sensor unit 64 into digital data of a voltage value.

  When the second chip 60b is mounted on the holder, a small current flows through the second resistor 63b as shown in the region 78. However, since the first resistor 63a and the second resistor 63b have different resistance values, the current values flowing through the electrode pairs 61 and 62 are also different. At this time, the control unit 74 can determine that the second chip 60b is attached to the holder by converting the current value flowing through the electrode pair 61, 62 into digital data of a voltage value.

  When the chip is mounted on the holder and the user's blood adheres to the sensor unit 64, an enzyme reaction is caused by the reagent applied to the sensor unit 64. At this time, a large current flows as shown in the region 79. For this reason, the control part 74 can measure the blood glucose level in the blood by converting the electric current value which the sensor part 64 detects into the digital data of a voltage value.

  According to the blood glucose level measuring apparatus 70 according to the second embodiment described above, the presence / absence of the chip and the type of the chip are identified using the current values flowing through the electrode pairs 61 and 62 built in the chip, Measure blood glucose level. For this reason, the timing at which the user measures the blood glucose level can be easily linked to the measurement data while simplifying the configuration of the chip itself.

  Further, the first chip 60a and the second chip 60b are provided with resistors 63a and 63b having different resistance values inside, so that the configuration is simplified. Further, unlike the optical blood glucose level measuring apparatus 1 described above, the blood glucose level measuring apparatus 70 does not require the light emitting unit 15 and the light receiving unit 16. For this reason, there is an effect that optical design becomes unnecessary and the apparatus can be simplified.

<3. Third Embodiment>
Next, a third embodiment of the present invention will be described with reference to FIGS.
In the present embodiment, an example in which the present invention is applied to an electrode-type blood glucose level measuring device 90 that identifies whether or not the timing at which a user measures a blood glucose level is after meals depending on the difference in the energization state of each chip and links it to the measurement result. explain. In the following description, parts corresponding to those in FIG. 11 already described in the second embodiment are denoted by the same reference numerals, and detailed description thereof is omitted.

FIG. 14 shows an internal configuration example of the chip.
The first chip 80a for post-meal measurement mounted after the user's meal includes a first electrode pair 81a, 81b, a sensor unit 83 including a site to which blood adheres (blood containing site), and a second electrode pair. 82a and 82b, and a resistor 84 that short-circuits the second electrode pair 82a and 82b. The sensor unit 83 is connected to the first electrode pair 81a, 81b.

  In this example, in addition to the second electrode pair 82a and 82b, a part including the resistor 84 is defined as an identification unit 85a. The first electrode pair 81 a and 81 b and the second electrode pair 82 a and 82 b are configured as a first electrode system and a second electrode system that are energized from the power supply 26 via the control unit 74.

  The second chip 80b mounted other than after the user's meal includes the first electrode pair 81a, 81b, the second electrode pair 82a, 82b, and the sensor unit 83 described above. The second chip 80b is different from the first chip 80a in that the resistor 84 is not provided and the electrodes 82a and 82b are opened. In this example, a part including the second electrode pair 82a and 82b is set as an identification unit 85b. Hereinafter, the first chip 80a or the second chip 80b may be simply referred to as “chip”. Since the second electrode pair 82a and 82b are open, it is possible to identify the type of chip described later without providing the second electrode pair 82a and 82b on the second chip 80b. is there.

FIG. 15 shows an example of the internal configuration of the blood sugar level measuring device 90.
The blood glucose level measuring device 90 includes a control unit 74 that controls each unit, an I / V conversion unit 71 that converts a current value supplied from the sensor unit 83 into a voltage value, and an amplification unit 72 that amplifies the converted voltage value. The A / D conversion unit 73 converts the amplified analog voltage value into digital data and supplies the digital data to the control unit 74.

  When the chip is mounted on a holder having connection terminals corresponding to the electrode pairs 81a, 81b, 82a, 82b, current flows through the resistor 84 through the second electrode pairs 82a, 82b of the first chip 80a. The current flowing through the second electrode pair 82a and 82b is directly input to the control unit 74. The control unit 74 includes an input / output port (not shown) composed of a transistor switch, and can identify a short circuit or an open circuit of the second electrode pair 82a and 82b.

  Thereby, the chip | tip identification part 75 can identify the kind of mounted | worn chip | tip. That is, if the current can be detected, the first chip 80a is attached, and if the current cannot be detected, the second chip 80b is attached.

  Next, when blood is accommodated in the sensor unit 83, the control unit 74 converts the current obtained by energizing the first electrode pair 81a and 81b into the I / V conversion unit 71, the amplification unit 72, and the A / D. Obtained as digital data of a voltage value via the converter 73. Next, the blood sugar level measuring unit 76 obtains the current value of the current supplied to the sensor unit 83 from the digital data of the voltage value. Then, the blood sugar level measuring unit 76 measures the blood sugar level of the blood adhering to the sensor unit 83 based on the current value obtained by energizing the first electrode pair 81a, 81b, and the blood sugar level measured together with the measurement time Is stored in the third memory.

  According to the blood glucose level measuring apparatus 90 according to the third embodiment described above, the type of the chip is identified based on the current value obtained from the identification units 85a and 85b built in the chip. Further, the blood glucose level in the blood is measured using the current value applied to the sensor unit 83. For this reason, the timing at which the user measures the blood glucose level can be easily linked to the measurement data while simplifying the configuration of the chip itself.

  The chip electrode system used in the second and third embodiments described above is a two-electrode system in which the electrode pair functions as a working electrode and a counter electrode, but it may also be a three-electrode system provided with a reference electrode. Good.

  Further, a recording medium in which a program code of software that realizes the functions of the first to third embodiments described above may be supplied to the system or apparatus. It goes without saying that the function is also realized by a computer (or a control device such as a CPU) of the system or apparatus reading and executing the program code stored in the recording medium.

  As a recording medium for supplying the program code in this case, for example, a floppy disk, a hard disk, an optical disk, a magneto-optical disk, a CD-ROM, a CD-R, a magnetic tape, a nonvolatile memory card, a ROM, or the like is used. Can do.

  Further, the functions of the above-described embodiment are realized by executing the program code read by the computer. In addition, based on the instruction of the program code, an OS (Operating System) running on the computer performs part or all of the actual processing. The case where the functions of the above-described embodiment are realized by the processing is also included.

Further, the present invention is not limited to the above-described embodiment, and it is needless to say that various other configurations can be taken without departing from the gist of the present invention.
For example, in the above-described embodiment, the type of the chip is identified based on the coloring of the test paper or the energization state of the electrode. However, the microswitch is provided in the measuring device, and the protrusion that can contact the microswitch is provided in the chip. Then, when the chip is mounted on the measuring device, a micro switch may be automatically entered to recognize the chip as a post-meal measuring chip.

  DESCRIPTION OF SYMBOLS 1 ... Blood glucose level measuring apparatus, 2 ... Display part, 3 ... Power button, 4 ... Call button, 5 ... Case, 6 ... Ejector, 7 ... Holder, 10a ... 1st chip | tip, 10b ... 2nd chip | tip, 11 DESCRIPTION OF SYMBOLS Case, 12 ... Thin tube, 13a, 13b ... Test paper, 14a ... Projection part, 15 ... Light emission part, 16 ... Light reception part, 17 ... A / D conversion part, 21 ... Control part, 22 ... Control oscillation part, 23 ... Clock oscillation unit, 24 ... Data storage unit, 25 ... External output unit, 26 ... Power supply, 27 ... Power supply voltage detection unit, 28 ... Operation unit, 29 ... Buzzer output unit, 31 ... Chip identification unit, 32 ... Blood glucose level measurement unit 70 ... Blood glucose level measuring device, 90 ... Blood glucose level measuring device

Claims (11)

A chip identification unit for identifying whether or not the first or second chip having a predetermined part for storing blood is mounted, and the type of the mounted first or second chip;
According to the type of the first or second chip identified by the chip identification unit, it is identified whether or not the timing of measuring blood adhering to the predetermined part is after a user's meal, A blood sugar level measurement unit for measuring the blood sugar level of blood adhering to the site;
A blood glucose level measuring apparatus comprising: a storage unit that stores the measured blood glucose level together with information related to the timing at which the blood glucose level is measured. The first chip is attached after the user's meal;
The second chip is mounted except after the meal,
When the predetermined portion is a test paper that develops color by storing the blood,
A light emitting unit for irradiating the predetermined part with a light beam having a predetermined wavelength;
When the first or second chip is attached, the light beam reflected from the predetermined portion is received, and when the first and second chips are not attached, light from the external environment is received. A light receiving unit that receives light and generates a light reception signal,
The chip identification unit measures a received light amount based on the received light signal, and based on the received light amount, whether or not the first or second chip is mounted, and the mounted first or second chip. Identify the chip type,
The blood sugar level measuring apparatus according to claim 1, wherein the blood sugar level measuring unit measures a blood sugar level of blood adhering to the predetermined part based on the received light amount. The amount of received light when blood is not stored in a predetermined part of the first and second chips is different from each other, and is outside the range in which the blood sugar level measuring unit measures the blood sugar level. Blood glucose level measuring device. The first chip is attached after the user's meal;
When the second chip is to be mounted other than after the meal,
The first and second chips are:
An electrode system comprising two or more electrodes energized from a power source;
A sensor unit connected to the electrode system and including the predetermined part,
The chip identification unit determines whether or not the first or second chip is mounted and the type of the mounted first or second chip based on the current value obtained by energizing the electrode system. Identify and
The blood sugar level measuring apparatus according to claim 1, wherein the blood sugar level measuring unit measures a blood sugar level of the blood adhering to the predetermined part based on the current value obtained by energizing the sensor part. The first and second chips are:
The blood glucose level measuring device according to claim 4, comprising resistors having different resistance values between the electrodes of the electrode system. The first chip is attached after the user's meal;
When the second chip is to be mounted other than after the meal,
The first and second chips are:
A first electrode system energized from a power source;
A second electrode system energized from the power source;
A sensor unit connected to the first electrode system and including the predetermined part,
The chip identification unit, based on the current value obtained by energizing the second electrode system, whether or not the first or second chip is mounted, and the mounted first or second chip Identify the type of
The blood sugar level measuring apparatus according to claim 1, wherein the blood sugar level measuring unit measures a blood sugar level of the blood adhering to the predetermined part based on the current value obtained by energizing the sensor part. The blood sugar level measuring apparatus according to claim 6, wherein one of the second electrode systems included in the first and second chips is short-circuited and the other is opened. The blood glucose level measuring device according to any one of claims 1 to 7, wherein the first and second chips are provided with different external identification information when viewed in appearance. Furthermore, the blood glucose level measuring apparatus of any one of Claims 1-8 provided with the display part which displays the timing when the said blood glucose level was measured, and the said measured blood glucose level. Identifying whether or not the first or second chip having a predetermined part for storing blood is mounted, and the type of the mounted first or second chip;
According to the identified type of the first or second chip, it is determined whether or not the timing of measuring the blood adhering to the predetermined part is after the user's meal, and the blood adhering to the predetermined part Measuring the blood sugar level of
Storing the measured blood glucose level together with information on the timing at which the blood glucose level is measured. A procedure for identifying whether or not a first or second chip having a predetermined part for containing blood is mounted, and a type of the mounted first or second chip;
According to the identified type of the first or second chip, it is determined whether or not the timing of measuring the blood adhering to the predetermined part is after the user's meal, and the blood adhering to the predetermined part The procedure for measuring the blood sugar level of
The program for making a computer perform the procedure which memorize | stores the measured said blood glucose level with the information regarding the timing when the said blood glucose level is measured.

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