JP2010035924A - Guide wire - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a guide wire, attaining moderate rigidity even when the guide wire is reduced in diameter, and having excellent operability. <P>SOLUTION: The guide wire 1 includes a wire body 2 having a core material formed of metal material having flexibility and shaped linear and a coating layer 6 coating at least part of the outer periphery of the core wire 3 and formed of resin material. In this guide wire 1, when the maximum outside diameter of the core wire 3 is Φd and the thickness of a portion having the maximum outside diameter of the core wire 3 in the coating layer 6 is t, t/d is 0.03-0.1. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to a guide wire, and more particularly, to a guide wire (a guide wire for a transendoscope) that is inserted into a living body via an endoscope.

  Some guidewires are used in the treatment of lesions of the bile duct and pancreatic duct to guide each treatment device to the vicinity of the lesion of the bile duct and pancreatic duct by, for example, transpapillary technique (ERCP (endoscopic retrograde cholangiopancreatography)). The transpapillary technique is to insert an endoscope into the descending part of the duodenum, and while looking at the Vater nipple in front of the endoscope, insert a contrast cannula into the bile duct and pancreatic duct, inject a contrast agent, and perform X-ray photography. It is a method of doing. As a guide wire used for this transpapillary technique (lesion treatment), a hollow tube made of polytetrafluoroethylene (Teflon: Teflon is a registered trademark) or the like is wrapped by heat shrinking from the core material of the guide wire. Is known (see, for example, Patent Document 1).

  When a transpapillary procedure is performed, for example, when a lesion in the bile duct is extremely (highly) narrowed or bent sharply, a guide wire used has a diameter of 0.025 inch (about 0.63 mm) (thinned) guide wire described in Patent Document 1 is selected. The guide wire having a diameter of 0.025 inch has a limit on the shrinkage of the hollow tube due to its structure, and the thickness of the wall portion does not become sufficiently thin even when heat shrinkage is applied. When the diameter of the hollow tube wall portion is not sufficiently reduced, the core material covered with the hollow tube had to be thinned. For this reason, the obtained guide wire has low (insufficient) rigidity (bending rigidity, torsional rigidity).

  Such a guide wire has a low rigidity as described above when guiding a treatment device such as a contrast cannula to the vicinity of a lesioned part with the guide wire placed in the bile duct. I get out. For this reason, there is a problem that the treatment device cannot be guided to the vicinity of the lesioned part.

  Also, in order to prevent the guide wire from slipping out of the bile duct during treatment device guidance, the guide wire is replaced with a guide wire having a higher rigidity (0.035 inch (about 0.89 mm) in diameter). Treatment device guidance may be performed. However, such an operation for exchanging the guide wire is complicated, and thus it has not been possible to perform rapid lesion treatment.

JP-T-9-501593

  An object of the present invention is to provide a guide wire that has a moderate rigidity and is excellent in operability even when the guide wire is reduced in diameter.

Such an object is achieved by the present inventions (1) to (5) below.
(1) A linear core material made of a flexible metal material, and a coating layer covering at least a part of the outer periphery of the core material and having at least one layer made of a resin material; A wire body having
When the maximum outer diameter of the core material is φd and the thickness of the coating layer at the maximum outer diameter portion of the core material is t, t / d is 0.03 to 0.1. To guide wire.

  (2) The guide wire according to (1), wherein the core member has a bending rigidity of 140 to 240 gf.

  (3) The guide wire according to (1) or (2), wherein the core member has a maximum outer diameter φd of 0.5 to 0.6 mm.

  (4) The guide wire according to any one of (1) to (3), wherein a thickness t of the coating layer is constant along a longitudinal direction of the wire body.

  (5) The guide wire according to any one of (1) to (4), wherein the metal material is a superelastic alloy.

  Moreover, it is preferable that the outer periphery of the core material is roughened or a metal oxide layer made of a metal oxide is formed.

The friction coefficient of the coating layer is preferably 0.01 to 0.1.
The resin material is preferably a fluororesin.

  It is preferable that the core member has a tapered portion whose outer diameter gradually decreases in the distal direction on the distal end side.

Provided with a marker having a function of indicating the position of the wire body in the living body, provided over substantially the entire circumference of the tapered portion;
The marker preferably has a shape that forms a lattice shape as a whole by intersecting the first linear portion and the second linear portion at a plurality of locations.
The covering layer preferably covers the marker.

In the marker, the first linear portion and the second linear portion are respectively raised in the radial direction of the wire body,
In the covering layer, it is preferable that the thickness of the portion covering the marker is thinner than the thickness of the marker.

At the intersection where the first linear portion and the second linear portion intersect, one of the first linear portion and the second linear portion overlaps the other. ,
In the covering layer, it is preferable that the thickness of the portion covering the intersecting portion is thinner than the thickness of the intersecting portion.

  According to the present invention, t / d is 0.03 to 0.1 when the maximum outer diameter of the core material is φd and the thickness of the core layer of the coating layer at the maximum outer diameter portion is t. As a result, the maximum outer diameter φd of the core material is ensured (excessively) even when the guide wire is reduced in diameter, for example, 0.025 inch (about 0.63 mm). Therefore, the guide wire has an appropriate bending rigidity.

  In addition, when such a guide wire is used to guide a treatment device such as a contrast cannula to the vicinity of the lesioned part of the living body lumen, the guide operation can be reliably performed, and thus operability is excellent.

  Hereinafter, the guide wire of the present invention will be described in detail based on a preferred embodiment shown in the accompanying drawings.

  1 is a partial longitudinal sectional view of a guide wire according to the present invention, FIG. 2 is a longitudinal sectional view of a region [A] surrounded by a dashed line in FIG. 1, and FIG. 3 is a marker in the guide wire shown in FIG. 4 is a cross-sectional view taken along line B-B in FIG. 3, FIG. 5 is a cross-sectional view taken along line C-C in FIG. 1, and FIG. 6 is a diagram illustrating a use example of the guide wire shown in FIG. FIG. 7 is a diagram showing a change process of the marker when the guide wire shown in FIG. 1 is rotated around its axis. FIG. 8 is a diagram showing the guide wire shown in FIG. It is a figure which shows the change process of the marker when it is moved. In the following, for convenience of explanation, the right side in FIGS. 1, 2, 7, and 8 is referred to as “base end”, the left side is referred to as “tip”, and the left side in FIG. Is called the "tip". Further, in FIG. 1, for ease of understanding, the length direction of the guide wire is shortened and the thickness direction of the guide wire is exaggerated and schematically illustrated. The ratio is different from the actual.

  A guide wire 1 shown in FIG. 1 is a guide wire for a catheter used by being inserted into a lumen (lumen 201) of a catheter (including an endoscope 20) (see FIG. 6), and is flexible or flexible. A wire body 2 having a spiral shape, a coil 4, a resin coating layer 6, an annular member (step filling member) 5, and a marker 12. The total length of the guide wire 1 is not particularly limited, but is preferably about 200 to 5000 mm.

  As shown in FIG. 1 and FIG. 5, the wire body 2 includes a long (linear) continuous core wire (core material) 3 and an outer periphery of the core wire 3 (excluding the outer periphery of the tip portion). And a coating layer 7 to be coated.

  The cross-sectional shape of the core wire 3 is circular (see FIG. 5). In the present invention, the core wire 3 is not limited to a single continuous core wire, and may be one in which a plurality of core wires (wires) made of the same or different materials are joined (connected) by, for example, welding or brazing. For example, when the core wire 3 is formed by joining two core wires, the joint portion may be located in any of a main body portion 32, a tapered portion 34, and a small diameter portion 36, which will be described later. .

  The core wire 3 extends over substantially the entire length of the guide wire 1, a main body portion 32 corresponding to the main body portion of the guide wire 1, a tapered portion (outer diameter gradually decreasing portion) 34 positioned on the front end side thereof, and a front end thereof It is comprised with the small diameter part 36 located in the side. The outer diameter of the main body portion 32 is substantially constant, the outer diameter of the tapered portion 34 is gradually reduced toward the tip direction (tapered), and the outer diameter of the small-diameter portion 36 is substantially the same. It is constant.

  By providing the taper portion 34 on the core wire 3, the flexibility of the core wire 3 gradually (continuously) increases from the vicinity of the boundary between the main body portion 32 and the taper portion 34 toward the distal end. As a result, the guide wire Since the flexibility of 1 increases, the operativity and safety | security at the time of inserting in a biological body improve.

  The marker 12 is formed from the middle of the tapered portion 34 to the base end side (see FIG. 1). As a result, the marker 12 is arranged on a relatively flexible portion of the guide wire 1 (wire body 2), that is, a portion that is easily deformed. Therefore, when the portion is curved (deformed), The degree of bending can be confirmed with certainty.

  Moreover, by having the small diameter part 36 in the front end side of the taper part 34, the cutting edge flexible part can be lengthened, and the effect that the cutting edge part becomes more flexible arises.

  Further, at least a part of the small-diameter portion 36 of the core wire 3 may be a reshape portion that can be reshaped (shaped). The shape of the reshape portion is preferably a flat plate shape or a prismatic shape.

  The outer diameter (maximum outer diameter) φd of the main body 32 of the core wire 3 is not particularly limited, but is preferably about 0.5 to 0.6 mm, and more preferably about 0.52 to 0.58 mm. . Thus, although depending on the thickness t of the coating layer 7 covering the core wire 3, the outer diameter of the guide wire 1 is set to 0.025 inch by setting the thickness t to a size described later. (About 0.63 mm). Generally, a guide wire having an outer diameter of 0.025 inches is a lesion (not shown) in the bile duct 30 when performing a transpapillary procedure (ERCP (endoscopic retrograde cholangiopancreatography)) as shown in FIG. Can be inserted into the bile duct 30 via the lumen 201 of the endoscope 20 when it is extremely (highly) narrowed or sharply bent. The guide wire 1 can be suitably used for such a procedure when the outer diameter becomes 0.025 inch.

  Although the outer diameter of the small diameter part 36 of the core wire 3 is not specifically limited, It is preferable to set it as about 0.05-0.3 mm, and it is more preferable to set it as about 0.1-0.2 mm. The outer diameter of the small-diameter portion 36 is not limited to a constant value, and the outer diameter may gradually decrease toward the tip.

  The length of the tapered portion 34 varies depending on the application and type of the guide wire 1 and is not particularly limited, but is preferably about 10 to 300 mm, more preferably about 30 to 250 mm.

  Moreover, the length of the small diameter part 36 is not specifically limited, However, Preferably it is about 0-100 mm, More preferably, it can be about 10-50 mm.

  In addition, the taper angle (decrease rate of the outer diameter) of the taper portion 34 may be constant along the longitudinal direction of the core wire 3 (wire body 2), or there may be a portion that varies along the longitudinal direction. Moreover, the taper part 34 may be provided not only in one place but in two or more places.

  As a constituent material of the core wire 3, a metal material can be used, and the metal material is not particularly limited. For example, superelasticity such as a Ni-Ti alloy, a Ni-Al alloy, a Cu-Zn alloy, etc. An alloy is mentioned.

  Moreover, the bending rigidity of the core wire 3 comprised with such a superelastic alloy (metal material) is not specifically limited, For example, it is preferable that it is 140-240 gf, and it is more preferable that it is 160-190 gf. The method for obtaining the bending rigidity in such a numerical range is not particularly limited. For example, a method for appropriately setting (adjusting) the mixing ratio of the composition constituting the superelastic alloy, a process for producing the superelastic alloy ( In the heat treatment step in step (step), a method of appropriately setting the temperature condition can be used.

  By the way, generally, the bending rigidity of a conventional guide wire having an outer diameter of 0.025 inch (hereinafter, this guide wire is referred to as “0.025 inch guide wire”) is about 42 gf. In addition, as a guide wire having higher bending rigidity than this guide wire, there is one having an outer diameter of 0.035 inch (about 0.89 mm) (hereinafter, this guide wire is referred to as “0.035 inch guide wire”). The bending rigidity is generally about 165 gf.

  For example, as shown in FIG. 6, when a transpapillary procedure is performed, if a lesion in the bile duct 30 is extremely (highly) narrowed or sharply bent, first, a 0.025 inch guide is used. A wire is inserted into the bile duct 30, and the endoscope 20 is inserted to the descending portion of the duodenum along the 0.025 inch guide wire in this inserted state (indwelling state). When the 0.025 inch guide wire is used to guide a treatment device such as a contrast cannula to the vicinity of the lesion, the guide wire has a relatively low bending rigidity (about 42 gf). The bile duct 30 may escape. Therefore, when guiding the treatment device to the vicinity of the lesion, the 0.025 inch guide wire is replaced with a 0.035 inch guide wire having a higher bending rigidity (about 165 gf), and the guide wire is replaced with the guide wire. The guidance operation is performed using.

  On the other hand, the guide wire 1 has an outer diameter similar to that of a 0.025 inch guide wire, but has a bending rigidity equal to or higher than that of a 0.035 inch guide wire. For this reason, the guide wire 1 can withstand the withdrawal from the bile duct 30 during the operation even when the treatment device is guided to the vicinity of the lesioned part in the state of being placed in the bile duct 30 (the state shown in FIG. 6). Thus, the guiding operation can be performed reliably. By using the guide wire 1 in this way, for example, the guide wire exchange operation described above in the transnipple operation can be omitted. Therefore, it can be said that the guide wire 1 is excellent in operability.

  In addition, it is preferable that the outer periphery of the core wire 3 is roughened, that is, roughened. Thereby, many minute unevenness | corrugations are formed in the outer periphery of the core wire 3, Therefore, the adhesiveness of the outer periphery of the core wire 3 and the coating layer 7 improves. Thereby, for example, when the guide wire 1 is bent sharply, it is possible to prevent minute peeling of the coating layer 7 from the core wire 3. Instead of roughening, a metal oxide layer made of metal oxide may be formed on the outer periphery of the core wire 3.

  Further, the coil 4 is disposed on the outer periphery of the distal end portion of the core wire 3 (wire body 2), that is, in the illustrated configuration, on the outer periphery of the small diameter portion 36 and the outer periphery up to the middle of the tapered portion 34. The coil 4 is a member formed by spirally winding (forming) a wire (thin wire) (wire material), and is installed so as to cover a tip side portion (outer periphery) of the core wire 3 (wire body 2). ing. In the configuration shown in the figure, a portion (tip portion) on the tip end side of the core wire 3 is inserted through a substantially central portion inside the coil 4. The portion on the tip side of the core wire 3 is inserted in a non-contact manner with the inner surface of the coil 4.

  The proximal end of the coil 4 is located in the middle of the taper portion 34 of the core wire 3, and the marker 12 is located closer to the proximal end than that. Thereby, positional interference between the coil 4 and the marker 12 can be prevented, and the structure of the guide wire 1 is simplified. The marker 12 may be formed up to the outer peripheral side of the coil 4, that is, may be formed so as to overlap the coil 4 in a side view.

  In the configuration shown in the figure, the coil 4 has a gap between the spirally wound strands in a state where no external force is applied, but unlike the illustration, the coil 4 is spiraled in a state where no external force is applied. The strands wound in a shape may be densely arranged without a gap.

  The coil 4 is preferably made of a metal material. Examples of the metal material constituting the coil 4 include stainless steel, superelastic alloy, cobalt-based alloy, noble metals such as gold, platinum, tungsten, and alloys containing these (for example, platinum-iridium alloy). In particular, when it is made of an X-ray opaque material such as a noble metal (a material having X-ray contrast properties), the guide wire 1 has X-ray contrast properties, and the tip position is confirmed under X-ray fluoroscopy. However, it can be inserted into a living body, which is preferable. Further, the coil 4 may be composed of different materials on the distal end side and the proximal end side. For example, the distal end side may be constituted by a coil made of an X-ray opaque material, and the proximal end side may be constituted by a coil made of a material that relatively transmits X-rays (such as stainless steel). The total length of the coil 4 is not particularly limited, but is preferably about 5 to 500 mm. In the case of this embodiment, the coil 4 has a circular cross section of the strand. However, the present invention is not limited to this, and the cross section of the strand is, for example, elliptical or quadrangular (particularly rectangular). It may be.

  The proximal end portion and the distal end portion of the coil 4 are fixed (fixed) to the core wire 3 by fixing materials 81 and 82, respectively.

  These fixing materials 81 and 82, that is, two fixing portions for fixing the core wire 3 and the coil 4 are provided on the distal end side from the annular member 5 described later, and are not in contact with the annular member 5. Thereby, it can prevent that the core wire 3 and the cyclic | annular member 5 electrically connect via the fixing material 81, and can prevent that the outer surface of the guide wire 1 and the core wire 3 electrically connect by this. .

  The fixing materials 81 and 82 are each made of solder (brazing material). Note that the fixing materials 81 and 82 are not limited to solder, and may be, for example, an adhesive. Moreover, the fixing method of the coil 4 is not limited to a fixing material, and for example, welding may be used.

  Further, the guide wire 1 has a resin coating layer 6 that covers the distal end portion of the core wire 3 (wire body 2), the coil 4, and the outer peripheries (outer surfaces) of the fixing materials 81 and 82. This resin coating layer 6 is in close contact with the outer periphery of the tip of the core wire 3.

  In the illustrated configuration, the resin coating layer 6 penetrates into the coil 4, but does not have to penetrate into the coil 4.

  The resin coating layer 6 can be formed for various purposes. As an example, the resin coating layer 6 can be provided for the purpose of improving safety when the guide wire 1 is inserted into the bile duct 30 or a blood vessel. For this purpose, the resin coating layer 6 is preferably made of a flexible material (soft material, elastic material). Examples of the material include polyolefins such as polyethylene and polypropylene, polyvinyl chloride, polyester (PET, PBT, etc.), polyamide, polyimide, polyurethane, polystyrene, silicone resin, polyurethane elastomer, polyester elastomer, polyamide elastomer, and other thermoplastic elastomers. , Various rubber materials such as latex rubber and silicone rubber, or composite materials obtained by combining two or more thereof.

  In particular, when the resin coating layer 6 is made of the above-described thermoplastic elastomer or various rubber materials, the flexibility of the distal end portion of the guide wire 1 is further improved. Sometimes, the wall surface or the like can be more reliably prevented from being damaged, and the safety is extremely high.

  In the resin coating layer 6, particles (filler) made of an X-ray opaque material (material having X-ray contrast properties) may be dispersed. Thereby, X-ray contrast property is obtained for the guide wire 1, and the guide wire 1 can be inserted into the living body while confirming the position of the tip under fluoroscopy. The material constituting the particles is not particularly limited as long as it is an X-ray opaque material. For example, a noble metal such as gold, platinum, or tungsten, or an alloy containing these (for example, platinum-iridium alloy) can be used.

  The thickness of the resin coating layer 6 is not particularly limited, and is appropriately determined in consideration of the purpose of forming the resin coating layer 6, the constituent material, the forming method, and the like. Usually, the thickness (average) is 30 to 30%. The thickness is preferably about 300 μm, and more preferably about 50 to 200 μm. If the thickness of the resin coating layer 6 is too thin, the purpose of forming the resin coating layer 6 may not be sufficiently exhibited. Moreover, when the thickness of the resin coating layer 6 is too thick, the physical characteristics of the wire body 2 (guide wire 1) may be affected. The resin coating layer 6 may be a laminate of two or more layers.

  Further, the tip surface of the resin coating layer 6 is rounded. Thereby, at the time of inserting the guide wire 1 into a blood vessel or the like, it is possible to more reliably prevent the bile duct 30 or the inner wall of the blood vessel from being damaged by the distal end surface of the resin coating layer 6 (guide wire 1).

  The guide wire 1 has an annular member 5 provided on the proximal end side of the resin coating layer 6 so as to fill a step space between the proximal end portion of the resin coating layer 6 and the wire body 2. The outer diameter of the base end of the resin coating layer 6 is larger than the outer diameter of the wire body 2 at the base end of the resin coating layer 6, and the step space is generated by a difference between these outer diameters.

  Further, the outer diameter of the distal end 52 of the annular member 5 is substantially equal to the outer diameter of the proximal end of the resin coating layer 6, and the distal end surface 53 of the annular member 5 is joined (adhered) to the proximal end surface 61 of the resin coating layer 6. ing. In this case, the resin coating layer 6 does not cover the annular member 5 beyond the distal end 52 of the annular member 5 toward the proximal end side. That is, a continuous surface without a step is formed between the tip 52 of the annular member 5 and the base end of the resin coating layer 6.

  Further, the outer diameter of the annular member 5 gradually decreases from the distal end side toward the proximal end side (toward the proximal direction), and the outer diameter of the proximal end 51 of the annular member 5 is smaller than the outer diameter of the distal end 52. small. The outer diameter of the base end 51 of the annular member 5 is substantially equal to the outer diameter of the wire body 2 (coating layer 7) at the base end 51 of the annular member 5. That is, a continuous surface without a step is formed between the wire body 2 (covering layer 7) and the base end 51 of the annular member 5. The outer diameter of the base end 51 of the annular member 5 is smaller than the outer diameter of the main body portion 32 of the core wire 3. The annular member 5 has a length of 0.5 to 15 mm.

  Further, the inner diameter of the base end 51 of the annular member 5 is larger than the inner diameter of the tip 52. This is because the annular member 5 is located at the tapered portion 34 of the core wire 3 as described later. Note that the inner diameter of the proximal end 51 may be the same as the inner diameter of the distal end 52.

  The annular member 5 can prevent the proximal end portion of the resin coating layer 6 from being caught by a medical instrument such as a distal end of a catheter used in combination with the guide wire 1 or a raising base of the endoscope 20. Thus, it is possible to prevent the resin coating layer 6 from being peeled off. Moreover, the fall of the slidability of the guide wire 1 by the said level | step difference can be prevented.

  In addition, the inclination angle θ (taper angle) (decrease rate of the outer diameter) of the annular member 5 is constant along the longitudinal direction of the core wire 3 (wire body 2) in the present embodiment. There may be a portion where the inclination angle θ varies along the longitudinal direction. The inclination angle θ is preferably 30 ° or less, more preferably about 2 to 25 °, and further preferably about 5 to 20 °. Thereby, it is possible to prevent the annular member 5 from being caught by a medical instrument such as a distal end of a catheter used in combination with the guide wire 1 or a raising base of the endoscope 20.

  The hardness (hardness) of the annular member 5 is preferably set higher than the hardness of the resin coating layer 6. Thereby, it is possible to prevent the annular member 5 from being caught by a medical instrument such as a distal end of a catheter used in combination with the guide wire 1 or a raising base of the endoscope 20.

  Moreover, either one or both of the front end surface 53 and the inner peripheral surface of the annular member 5 may be roughened. When the front end surface 53 of the annular member 5 is roughened, the adhesion with the resin coating layer 6 is improved, and when the inner peripheral surface is roughened, the adhesion with the fixing material 9 described later is achieved. Improves.

  Moreover, it does not specifically limit as a constituent material of the annular member 5, For example, various resin materials, various metal materials, etc. can be used. For example, the same constituent material as that of the resin coating layer 6 can be used, or a constituent material different from that of the resin coating layer 6 can be used.

  However, the annular member 5 is preferably made of a metal material (metal) or a hard resin material (resin), and particularly preferably made of a metal material. As a metal material constituting the annular member 5, for example, stainless steel, titanium, titanium alloy, Ni—Ti alloy, aluminum, gold, platinum, or the like can be used. X-ray contrast properties are improved by using precious metals such as gold and platinum, or alloys thereof. When the annular member 5 is made of a metal material, the outer periphery of the annular member 5 may be covered with a coating layer (not shown). The constituent material of the coating layer is not particularly limited, and for example, various resin materials, various ceramics, various metal materials, and the like can be used. In particular, it is preferable to use an insulating material. When the annular member 5 is made of a hard resin material, for example, polycarbonate, polyamide (nylon), polyethylene terephthalate, polyacetal, polyphenylene sulfide, or the like can be used.

  The annular member 5 is fixed (fixed) to the core wire 3 (wire body 2) by a fixing material 9 provided on the outer periphery of the core wire 3 (wire body 2).

  The fixing material 9 is made of an adhesive, and is particularly preferably made of an insulating adhesive. Thereby, the core wire 3 and the annular member 5 can be insulated, and, for example, when a medical instrument to be used by passing an electric current is disposed along the guide wire 1, the leakage from the outer surface of the annular member 5 Etc. can be prevented.

  Note that the fixing material 9 is not limited to an adhesive. For example, when the annular member 5 is made of a metal material, solder (brazing material) or the like may be used. Needless to say, the fixing method of the annular member 5 is not limited to the fixing method.

  Moreover, the annular member 5 is located in the taper part 34 of the core wire 3 (wire main body 2). In the illustrated configuration, the entire annular member 5 (entire) is located at the tapered portion 34, but not limited to this, only a part of the annular member 5 may be located at the tapered portion 34.

  The annular member 5 has a function of reducing the difference in rigidity (bending rigidity, torsional rigidity) between the proximal end side and the distal end side from the annular member 5 of the wire body 2. That is, as described above, the outer diameter of the tapered portion 34 of the core wire 3 gradually decreases in the distal direction, and the rigidity decreases in the distal direction. On the other hand, the resin coating layer 6 is provided on the distal end side of the annular member 5 of the wire body 2. When the annular member 5 is not provided, the rigidity of the resin coating layer 6 is rapidly increased at the base end. It increases and tends to cause kinks (bending). However, in this guide wire 1, the annular member 5 prevents a sudden increase in rigidity at the proximal end of the resin coating layer 6, and can prevent kinking at the proximal end of the resin coating layer 6.

  As described above, the guide wire 1 is not only used under X-ray fluoroscopy but also used through the endoscope 20, more specifically, a catheter inserted into the lumen 201 of the endoscope 20 is a living body. The present invention can also be applied to a guide wire used to guide a target site such as a lumen (for example, the bile duct 30) (hereinafter sometimes referred to as “transendoscopic guide wire”). Hereinafter, in the present embodiment, a case where the guide wire 1 is applied to a transendoscopic guide wire will be described as a representative example.

  In the transendoscopy guide wire, a visual marker having a function of indicating the position of the guide wire 1 (wire body 2) in the living body is provided on the outer surface of the guide wire 1, and the visual recognition is performed via the endoscope 20. Visually recognize the marker. In the present embodiment, the marker 12 corresponds to the visual marker. The marker 12 is mainly provided over substantially the entire circumference of the taper portion 34 of the wire body 2 through the base layer (intermediate layer) 13 (see FIG. 2). Moreover, as shown in the figure, a part (base end portion) of the marker 12 may hang on the main body portion 32 of the wire main body 2. In the guide wire 1, the coating layer 7 also covers the marker 12 and the base layer 13 (see FIG. 2). Thereby, the marker 12 and the base layer 13 are protected. In addition, this coating layer 7 has transparency to such an extent that the marker 12 can be visually recognized.

  As shown in FIG. 1, the marker 12 includes a first linear portion 121 and a second linear portion 122.

  The first linear portion 121 is spirally wound. Thereby, the 1st linear part 121 is provided over the perimeter of the wire main body 2 (taper part 34). Moreover, the 1st linear part 121 is the sparse winding from which adjacent lines were spaced apart.

  The second linear portion 122 has a spiral shape similar to the first linear portion 121, but the winding direction is opposite to the spiral winding direction of the first linear portion 121. It has become. Thereby, the 2nd linear part 122 is provided over the perimeter of the wire main body 2. FIG. Moreover, the 2nd linear part 122 is the sparse winding which the adjacent line | wires spaced apart similarly to the 1st linear part 121. FIG.

  Since the first linear portion 121 and the second linear portion 122 are formed in this manner, these linear portions intersect each other at a plurality of locations. The overall shape forms a lattice shape.

  As shown in FIG. 2, each of the first linear portion 121 and the second linear portion 122 is raised in the radial direction of the wire body 2 so that the longitudinal cross-sectional shape thereof is a semi-cylindrical shape. Yes, and its top is curved convexly. Moreover, although the height of the 1st linear part 121 and the 2nd linear part 122 is not specifically limited, For example, it is preferable that it is 3-8 micrometers, and it is more preferable that it is 3-5 micrometers.

  When the guide wire 1 is observed from outside the body through the imaging unit 202 of the endoscope 20, the marker 12 is observed in a state as shown in FIGS. A case where the guide wire 1 is rotated around its axis will be described with reference to FIG. 7, and a case where the guide wire 1 is moved along the axial direction will be described with reference to FIG.

First, the case where the guide wire 1 is rotated around its axis will be described.
FIG. 7A shows a state before the guide wire 1 is rotated. Then, when the guide wire 1 is rotated by a predetermined amount (angle) in the direction of the arrow in the figure, the state shown in FIG.

  As described above, the marker 12 is formed with a plurality of intersections (intersection points) 123 where the first linear portion 121 and the second linear portion 122 intersect (see FIG. 1). Here, the first linear portion 121 and the second linear portion 122 (in FIG. 7A) that are captured through the imaging means 202 of the endoscope 20 and can be actually observed. Focusing on the intersections 123a, 123b, 123c, 123d, 123e, and 123f, these intersections 123a to 123f move downward in the figure in FIG. 7B than in the state of FIG. 7A. is doing.

  By being able to visually recognize the marker 12 in this way, when the guide wire 1 is torqued and the guide wire 1 is rotated around its axis, it is surely confirmed that the “guide wire 1 has rotated”. You can do it.

  Further, when the guide wire 1 is rotated in the direction opposite to the above, the intersecting portions 123a to 123f move upward in the drawing from the state of FIG. Thereby, it is possible to confirm in which direction the guide wire 1 is rotating, that is, the rotation direction of the guide wire 1.

Next, the case where the guide wire 1 is moved along the axial direction will be described.
FIG. 8A shows a state before the guide wire 1 is moved. Then, when the guide wire 1 is moved by a predetermined amount (distance) in the direction of the arrow in the figure, the state shown in FIG.

  Here, the first linear portion 121 and the second linear portion 122 (in FIG. 8A) that are captured through the imaging means 202 of the endoscope 20 and can be actually observed. Paying attention to the intersections 123a to 123f, these intersections 123a to 123f are moving toward the tip direction (left side in the figure) rather than the state of FIG. 8A in FIG. 8B. . Further, the intersecting portions 123a and 123b deviate (disappear) from the viewing angle (viewing area).

  Since the marker 12 can be visually recognized in this way, when the guide wire 1 is pushed in the distal direction and the guide wire 1 is moved along the axial direction, “the guide wire 1 has moved”. Can be confirmed (understood) reliably.

  Further, when the guide wire 1 is pulled and moved in the opposite direction, the intersecting portions 123a to 123f move in the proximal direction (rightward in the drawing) rather than the state of FIG. Thereby, it is possible to confirm in which direction the guide wire 1 is moving, that is, the moving direction of the guide wire 1.

  As described above, in the guide wire 1, when the guide wire 1 is moved along the axis or rotated around the axis, the actual displacement of the guide wire 1 can be moved by the above-described change of the marker 12. It is possible to reliably identify whether it is a rotation or not.

  Further, in a conventional guide wire having a single spiral marker, even if a torque is applied to the guide wire and the guide wire is rotated around its axis, the guide wire is contrary to the intention that it has been rotated. The illusion is that it is moving forward or backward (moving). However, the guide wire 1 can reliably prevent such an illusion (problem) and is excellent in operability.

  As shown in FIG. 1, at the same position in the axial direction of the wire body 2, that is, at the body portion 32 and the taper portion 34 of the wire body 2, the helical pitch and the second linear shape of the first linear portion 121. The pitch of the spiral of the part 122 is the same size. Thereby, the some crossing part 123 is disperse | distributed suitably in the formation area of the marker 12, Therefore The visibility with respect to each crossing part 123 improves. Moreover, there exists an advantage that it becomes easy to distinguish rotation of the guide wire 1 and pushing / pulling (movement) of the guide wire 1.

  In addition, the marker 12 is formed with a pitch reduction portion 124 in which the pitch of each spiral of the first linear portion 121 and the second linear portion 122 is gradually reduced toward the distal end at the tapered portion 34. Yes. By confirming this pitch reduction part 124, it can be grasped that the wire main body 2 is thin at that part and is easily deformed (highly flexible).

  As shown in FIG. 1 (the same applies to FIGS. 7 and 8), the width (average) of the first linear portion 121 and the width (average) of the second linear portion 122 are the same size. ing. Thereby, when forming the marker 12, changing the width | variety according to each linear part can be abbreviate | omitted. Therefore, the marker 12 can be easily formed.

  In addition, it is preferable that the width | variety of the 1st linear part 121 and the 2nd linear part 122 is respectively 0.5-2 times the average diameter of the wire main body 2, and is 0.5-1.5. More preferably, it is double. If the upper limit of such a numerical range is exceeded, halation may occur depending on the intensity of light emitted from the endoscope 20 when the marker 12 is viewed.

  The first linear portion 121 and the second linear portion 122 may have the same color or may be different from each other, but are preferably different from each other. When the first linear portion 121 and the second linear portion 122 are different from each other, when the guide wire 1 is rotated around its axis, the first linear portion 121 and the second linear portion If it is visually recognized that they are separated from each other, it can be seen that the rotation is in the direction of the arrow in FIG. On the contrary, if the first linear portion 121 and the second linear portion 122 are viewed so as to approach each other, the above is opposite, that is, opposite to the arrow direction in FIG. You can see that the direction is rotating.

  As shown in FIG. 3, the second linear portion 122 overlaps the first linear portion 121 at the intersection 123 of the marker 12. For this reason, the height of the intersecting portion 123 is higher than the height (thickness) of the other portion, that is, the portion excluding the intersecting portion 123 of the first linear portion 121 and the second linear portion 122. It has become. In addition, although the height h of the cross | intersection part 123 is not specifically limited, For example, it is preferable that it is 3-10 micrometers, and it is more preferable that it is 5-8 micrometers.

  The first linear portion 121 and the second linear portion 122 are each made of a material containing a resin and a pigment. Since the constituent material of the 1st linear part 121 and the constituent material of the 2nd linear part 122 are substantially the same, the constituent material of the 1st linear part 121 is demonstrated typically below.

  The color of the first linear part 121 mainly depends on the type and characteristics of the pigment contained in the first linear part 121, the composition and characteristics (particularly color tone, etc.) of the resin material, and the pigment content. They can be set freely by adjusting them.

  Here, in order to recognize the movement of the guide wire 1 through the endoscope 20, the color of the first linear portion 121 is one of important elements, and this is the color of the base layer 13 that is the base. Should be considered in combination.

  As an example, when the underlayer 13 is silver white (metallic color), gray or black, and the first linear portion 121 is red or yellow, the difference in brightness between the two colors is large (high contrast). Thereby, the visibility of the first linear portion 121 is high and preferable. Similarly, when the two colors have a complementary color relationship, for example, the visibility of the first linear portion 121 is high, which is preferable. Also, for example, clear contrast such as yellow, yellow-green, orange, etc. for black or dark colors (charcoal gray, dark brown, dark blue, purple, etc.), red, orange, pink, etc. for blue It is particularly preferable to select a combination that expresses. Further, similar colors with different shades, for example, amber and light blue, red beans and pink may be used.

  Although it does not specifically limit as resin contained in the constituent material of the 1st linear part 121, It is preferable that it is following (1) or (2).

  (1) As the resin included in the constituent material of the first linear portion 121, it is preferable to use a resin (heat-resistant resin) having a melting point of 200 ° C. or higher, and it is preferable to use a resin having a melting point of about 200 to 300 ° C. More preferred.

  Examples of the resin having a melting point of 200 ° C. or higher include polysulfone, polyimide, polyether ether ketone, polyarylene ketone, polyphenylene sulfide, polyarylene sulfide, polyamideimide, polyetherimide, polyimidesulfone, polyallylsulfone, and poloallyl. Fluorine-based resins such as ether sulfone, polyester, polyether sulfone, polytetrafluoroethylene (PTFE), ethylene-tetrafluoroethylene copolymer (ETFE), etc. They can be used in combination.

  (2) As the resin contained in the constituent material of the first linear portion 121, it is preferable to use a thermosetting resin.

  Examples of the thermosetting resin include epoxy resins, phenol resins, polyesters (unsaturated polyesters), polyimides, silicone resins, polyurethanes, and the like, and one or more of these can be used in combination. .

  Further, the content of the pigment in the first linear part 121 depends on the kind and characteristics of the pigment and the composition and characteristics of the resin material, but in order to obtain a good color, the first linear part 121 is used. The total amount is preferably about 10 to 99% by weight, more preferably about 20 to 50% by weight.

  The pigment in the first linear portion 121 is preferably uniformly dispersed, but may be unevenly distributed on the outer surface side of the first linear portion 121, for example. The pigment may be either an inorganic pigment or an organic pigment, but is preferably an inorganic pigment from the viewpoint of heat resistance. As the inorganic pigment, carbon black, mica, titanium dioxide, nickel titanium yellow, Prussian blue, milory blue, cobalt blue, ultramarine, viridian and the like can be used. In addition, a pigment may be used individually by 1 type and may use 2 or more types together (especially mixing). Moreover, the average particle diameter of a pigment is not specifically limited, For example, it is preferable that it is 0.3-5 micrometers, and it is more preferable that it is 0.5-3 micrometers.

Such a marker 12 can be formed as described below, for example.
Of the first linear portion 121 and the second linear portion 122, the first linear portion 121 is formed ahead of the second linear portion 122.

  In order to form the first linear portion 121, first, a masking tape is spirally wound around the core wire 3 to be the wire body 2 except for a region where the first linear portion 121 is to be formed. Turn and paste.

  Next, the liquid resin material to which the pigment is added (hereinafter referred to as “liquid material”) is applied (applied) to an exposed portion where the masking tape of the core wire 3 is not wound. Examples of the application method include a method using a spray and a method using immersion.

  Next, the applied liquid material is dried. Thereafter, the masking tape is peeled off (removed).

  By such a process, the first linear portion 121 can be formed. Next, the second linear portion 122 is formed.

  In order to form the second linear portion 122, first, the core wire 3 on which the first linear portion 121 is formed is masked on a portion other than the region where the second linear portion 122 is to be formed. A tape is spirally wound in the opposite direction to the above and attached.

  Next, as in the case of forming the first linear portion 121, a liquid material is applied to the exposed portion where the masking tape of the core wire 3 is not wound.

  Next, the applied liquid material is dried. Thereafter, the masking tape is peeled off (removed).

  By such a process, the second linear portion 122 that partially overlaps the first linear portion 121 can be formed. Therefore, it is possible to easily and reliably form the lattice-like marker 12 with the raised intersection 123.

  In addition, the 1st linear part 121 and the 2nd linear part 122 may each be formed 1 each, and may be formed in multiple numbers. Moreover, the number of them formed may be the same or different.

  Further, the first linear portion 121 and the second linear portion 122 have the same width in the configuration illustrated in FIG. 1, but are not limited thereto, and may have different widths.

  As shown in FIGS. 2 and 4, a base layer 13 having a color different from that of the marker 12 is formed between the marker 12 and the wire body 2. The constituent material of the base layer 13 is not particularly limited, and for example, a fluororesin (or a composite material including the same) can be used. When a fluorine-based resin is used as the constituent material of the foundation layer 13, the core wire 3 can be coated with the resin material heated by a method such as baking or spraying. Thereby, the adhesiveness of the core wire 3 and the base layer 13 becomes especially excellent. Then, the marker 12 and the covering layer 7 are fixed to the core wire 3 through the base layer 13.

  The average thickness of the underlayer 13 is not particularly limited, but is preferably 3 to 20 μm, and more preferably 5 to 10 μm, for example.

  As described above, the wire body 2 has the coating layer 7 that covers (covers) the outer periphery of the core wire 3 (see, for example, FIG. 5).

  The covering layer 7 can be formed for various purposes. As an example, the coating layer 7 can improve the operability of the guide wire 1 by reducing the friction (sliding resistance) of the guide wire 1 and improving the slidability. There are things to do.

  In order to reduce the friction (sliding resistance) of the guide wire 1, the coating layer 7 is preferably made of a material (resin material) that can reduce friction as described below. Thereby, for example, the friction resistance (sliding resistance) of the inner wall of the catheter used together with the guide wire 1 is reduced and the slidability is improved, and the operability of the guide wire 1 in the catheter and the endoscope 20 is improved. It will be something. Further, since the sliding resistance of the guide wire 1 is lowered, when the guide wire 1 is moved and / or rotated in the endoscope 20 (the same applies to the catheter), the guide wire 1 is kinked (bent) or twisted. Can be prevented more reliably.

  The covering layer 7 is preferably made of an insulating material. The reason is that the tip of the coating layer 7 enters the annular member 5 and the annular member 5 is positioned on the outer periphery of the coating layer 7. Can be insulated. Thereby, for example, when a medical instrument to be used by passing an electric current is disposed along the guide wire 1, leakage from the outer surface of the annular member 5 can be prevented.

  Examples of insulating materials that can reduce such friction include polyolefins such as polyethylene and polypropylene, polyvinyl chloride, polyesters (PET, PBT, etc.), polyamides, polyimides, polyurethanes, polystyrenes, polycarbonates, silicone resins, and fluorine resins. (PTFE, ETFE, PFA, etc.) or a composite material thereof.

  In particular, when a fluorine-based resin (or a composite material containing the same) is used, the frictional resistance (sliding resistance) between the guide wire 1 and the inner wall of the catheter is more effectively reduced, and slidability is improved. This can improve the operability of the guide wire 1 in the catheter. Thereby, when the guide wire 1 is moved and / or rotated in the endoscope 20, kink (bending) or twist of the guide wire 1 can be more reliably prevented.

  Moreover, it is preferable that the friction coefficient of the coating layer 7 comprised with such a resin material is 0.01-0.1, and it is more preferable that it is 0.02-0.06. When the coefficient of friction is within such a numerical range, the operability of the guide wire 1 in the catheter or the endoscope 20 is further improved. Further, when used in combination with a contrast agent, the contrast agent can be prevented from adhering to the guide wire 1, and there is an advantage that the so-called “stack phenomenon” is hardly caused.

  In the guide wire 1, the ratio t / d between the thickness t of the core wire 3 of the coating layer 7 at the body portion 32 and the outer diameter φd of the core wire 3 is 0.03 to 0.1 (see FIG. 5). ). Further, the ratio t / d is more preferably 0.03 to 0.08, and further preferably 0.03 to 0.06.

  When the ratio t / d is less than 0.03, when the guide wire 1 is inserted into the lumen 201 of the endoscope 20 and the guide wire 1 is operated, the coating layer 7 of the guide wire 1 removes the lumen 201. Depending on the operating conditions, the coating layer 7 may be peeled off from the core wire 3 by coming into contact with the defining wall. Here, the “operation condition” refers to, for example, the rotational speed around the axis of the guide wire 1 and the size of the tockle, the moving speed along the axial direction, the magnitude of the pushing force, and the wall portion that defines the lumen 201. Roughness, rubbing (friction) with a metal part called “raising stand” located at the tip of the lumen 201 of the endoscope 20, and the like.

  Further, when the ratio t / d exceeds 0.1, when the guide wire 1 has an outer diameter of 0.025 inch, the outer diameter φd of the core member 3 becomes smaller than the entire outer diameter, As described above, the guide wire 1 with a bending rigidity of 140 to 200 gf, that is, with sufficient bending rigidity may not be obtained. For this reason, even if the treatment device is guided to the vicinity of the lesioned part with the guide wire 1 placed in the bile duct 30 (the state shown in FIG. 6), the guide wire 1 may come out of the bile duct 30 during the operation. is there. In this case, as described above, the guide wire must be exchanged.

  When the ratio t / d is within the above numerical range, the outer diameter φd of the core wire 3 can be ensured without excess or deficiency even when the guide wire 1 is reduced in diameter, for example, 0.025 inch. The guide wire 1 has an appropriate (sufficient) bending rigidity. Moreover, when performing the said transpapillary procedure using such a guide wire 1, the exchange operation of the guide wire mentioned above can be abbreviate | omitted, and it is excellent in the operativity.

  It should be noted that the fact that the ratio t / d is in the numerical range may be satisfied not only in the main body portion 32 but also in the tapered portion 34, for example.

  Moreover, as shown in FIG. 1, the coating layer 7 is a layer whose thickness t is constant along the longitudinal direction of the guide wire 1 (wire body 2). For example, when the coating layer 7 is formed by applying a liquid resin material constituting the coating layer 7 to the outer periphery of the core wire 3 and drying it, the liquid material is applied. By making the amount constant, the coating layer 7 having a constant thickness t can be easily formed. Furthermore, the coating layer 7 having a ratio t / d can be easily formed (obtained) by a simple operation of adjusting the coating amount of the liquid material.

  Further, as described above, the marker 12 is covered with the covering layer 7. On the outer surface (outer surface of the guide wire 1) of the covering layer 7, the portion where the intersecting portion 123 (marker 12) is arranged protrudes from the portion where the marker 12 is not arranged. That is, a raised portion (a raised portion) (convex portion) 71 is formed at a portion where the intersecting portion 123 is disposed, and a depressed portion (a depressed portion) (recessed portion) is formed at a portion where the marker 12 is not disposed. 72 is formed. This is because the thickness t of the coating layer 7 is thin as described above, and the outer surface of the coating layer 7 is affected by the intersection 123 and corresponds to the shape and pattern of the intersection 123. This is because it rises (becomes a corresponding shape).

  As a result, the contact area between the outer surface of the covering layer 7 and the lumen of the catheter or the lumen 201 of the endoscope 20 is reduced, the frictional resistance (sliding resistance) is reduced, and the slidability is improved. The operability of the wire 1 is good.

  Further, the raised portion 71 and the recessed portion 72 are not formed by directly processing the coating layer 7 but are formed by the influence of the intersecting portion 123 immediately below the coating layer 7. No sharp corners or tops are formed on the surface, and the outer surface becomes smooth. In other words, the raised portion 71 has the same roundness as the top of the first linear portion 121 and the second linear portion 122. As a result, the slidability is further improved and the safety is very high.

As shown in FIG. 2, in the covering layer 7, the thickness t ₁ of the portion covering the first linear portion 121 (marker 12) is the height (thickness) h of the first linear portion 121. _It is smaller than ₁ (the same applies to the second linear portion 122). This prevents the covering layer 7 from being peeled off from the first linear portion 121 at this portion during the operation of the guide wire 1. Further, there is an advantage that the hue of the first linear portion 121 (second linear portion 122) can be visually recognized more clearly.

As shown in FIG. 4, in the covering layer 7, the thickness t _{2 of the} portion (the raised portion 71) that covers the intersecting portion 123 of the marker 12 is smaller than the height h of the intersecting portion 123. As a result, as in the case of t ₁ <h ₁ , the covering layer 7 is prevented from being peeled off from the second linear portion 122 at the raised portion 71 during the operation of the guide wire 1.

In the coating layer 7, the thickness t ₁ and the thickness t ₂ may be the same or different. When the thickness t ₁ and the thickness t ₂ are different, the thickness t ₂ may be larger (thicker) than the thickness t _1, but the thickness t ₂ is smaller (thinner) than the thickness t _1. Is preferred.

  Further, in the guide wire 1, in the vicinity of the proximal end side from the tapered portion 34, as shown in FIG. 2, the coating layer 7 and the base layer 13 cover the outer periphery of the core wire 3, and these two layers cover the coating layer. Become. In this case, the thickness t of the coating layer is the total thickness of the coating layer 7 and the base layer 13.

  In addition, it is preferable that a hydrophilic material is coated on at least the outer surface of the distal end portion of the guide wire 1. As a result, the hydrophilic material is wetted to produce lubricity, the friction (sliding resistance) of the guide wire 1 is reduced, and the slidability is further improved. Therefore, the operability of the guide wire 1 is further improved.

  Examples of hydrophilic materials include cellulose-based polymer materials, polyethylene oxide-based polymer materials, and maleic anhydride-based polymer materials (for example, maleic anhydride copolymers such as methyl vinyl ether-maleic anhydride copolymer). Acrylamide polymer substances (for example, polyacrylamide, polyglycidyl methacrylate-dimethylacrylamide (PGMA-DMAA) block copolymer), water-soluble nylon, polyvinyl alcohol, polyvinylpyrrolidone and the like.

  Such a hydrophilic material often exhibits lubricity by wetting (water absorption), and friction resistance (sliding resistance) with a catheter (tubular body) used with the guide wire 1 or the inner wall of the endoscope 20. Reduce. Thereby, the slidability of the guide wire 1 is further improved, and the operability of the guide wire 1 in the catheter is further improved.

  As mentioned above, although the guide wire of this invention was demonstrated about embodiment of illustration, this invention is not limited to this, Each part which comprises a guide wire is a thing of arbitrary structures which can exhibit the same function. Can be substituted. Moreover, arbitrary components may be added.

  Further, the first linear portion and the second linear portion are not limited to those formed by drying the liquid material, for example, a belt-shaped (ribbon-shaped) member is spirally wound. It may be a thing.

  Further, the thickness of the coating layer is not limited in the core portion of the core wire along the longitudinal direction of the wire body. For example, the coating layer may have a portion whose thickness has changed. .

It is a partial longitudinal cross-sectional view of the guide wire of this invention. FIG. 2 is a longitudinal sectional view of a region [A] surrounded by a one-dot chain line in FIG. It is a perspective view of the marker in the guide wire shown in FIG. FIG. 5 is a sectional view taken along line BB in FIG. 3. It is CC sectional view taken on the line in FIG. It is a schematic diagram for demonstrating the usage example of the guide wire shown in FIG. It is a figure which shows the change process of a marker when the guide wire shown in FIG. 1 is rotated around the axis | shaft. It is a figure which shows the change process of a marker when the guide wire shown in FIG. 1 is moved along the axial direction.

Explanation of symbols

1 Guide wire 2 Wire body 3 Core wire (core material)
32 Main body part 34 Tapered part 36 Small diameter part 4 Coil 5 Ring member 51 Base end 52 Front end 53 Front end face 6 Resin coating layer 61 Base end face 7 Coating layer 71 Raised part 72 Depression part 81, 82 Fixing material 9 Fixing material 12 Marker 121 1 linear portion 122 second linear portion 123, 123a, 123b, 123c, 123d, 123e, 123f Intersection (intersection)
124 Pitch reduction part 13 Underlayer (intermediate layer)
20 Endoscope 201 Lumen 202 Imaging means 30 Bile duct φd Outer diameter (maximum outer diameter)
_h, h ₁ height (thickness)
t, t ₁ , t ₂ thickness θ inclination angle

Claims (5)

A wire having a linear core material made of a flexible metal material and a coating layer covering at least a part of the outer periphery of the core material and having at least one layer made of a resin material With a body,
When the maximum outer diameter of the core material is φd and the thickness of the coating layer at the maximum outer diameter portion of the core material is t, t / d is 0.03 to 0.1. To guide wire.   The guide wire according to claim 1, wherein the core member has a bending rigidity of 140 to 240 gf.   The guide wire according to claim 1, wherein a maximum outer diameter φd of the core material is 0.5 to 0.6 mm.   The guide wire according to any one of claims 1 to 3, wherein a thickness t of the coating layer is constant along a longitudinal direction of the wire body.   The guide wire according to claim 1, wherein the metal material is a superelastic alloy.

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