JP2009268611A - Method for estimating skin internal structure of blemish region - Google Patents
Method for estimating skin internal structure of blemish region Download PDFInfo
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Abstract
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本発明は、シミ部位の皮膚内部構造推定法に関し、詳しくは、シミ部位の画像情報を元にして、シミ発現の微細パターンを分類し、その分類に基いて、皮膚内部構造に関する情報を推定し、美容情報として利用することに関する。 The present invention relates to a method for estimating the skin internal structure of a spot site. More specifically, the fine pattern of stain expression is classified based on the image information of the spot site, and information on the skin internal structure is estimated based on the classification. , Relating to use as beauty information.
色素沈着のうち、いわゆるシミと表現される皮膚症状には、肝斑、雀卵斑、老人性色素斑などの種々の色素病変が含まれる。シミを拡大観察した結果、その見え方には幾つかのパターンがあることが報告されている（非特許文献１）。しかしながら、シミの見え方のパターンと、その皮膚内部構造と関連性については何ら報告されていない。一般に、皮膚内部構造に関する情報を得るには、皮膚切除（バイオプシー）・組織固定・染色してから観察するという、高度でかつ煩雑な処理を行なう必要がある。化粧品業界のような健常女性を主なターゲットとする分野においては、皮膚切除という医療従事者のみに許される行為は現実的には極めて困難であり、化粧品分野においては健常女性のシミ部位の皮膚内部に関する研究はほとんど行われていないのが現状である。 Among pigmentation, skin symptoms expressed as so-called spots include various pigment lesions such as liver spots, sparrow egg spots, and senile pigment spots. As a result of magnifying the spot, it has been reported that there are several patterns in its appearance (Non-Patent Document 1). However, there is no report on the pattern of the appearance of the stain and the relationship with the internal structure of the skin. In general, in order to obtain information on the internal structure of the skin, it is necessary to perform sophisticated and complicated processing such as skin resection (biopsy), tissue fixation, and observation after observation. In the field that targets healthy women as the main target, such as the cosmetics industry, it is actually extremely difficult to perform skin excision, which is permitted only by medical professionals. There is almost no research on the current situation.
一方、近年の測定技術の進歩により、皮膚切除を伴うことなく非侵襲的に皮膚内部構造を観察する手法が開発されてきている。In vivo 共焦点レーザー顕微鏡観察はそのような手法のひとつであり、非侵襲的に皮膚内部の断面像を得ることが可能である。この手法を応用して、皮膚内部情報を得る試みがされている（例えば、特許文献１〜５）。しかしながら、このような手法は特別な測定機器を必要とするものであり、例えば販売店の店頭などで美容に係るカウンセリング情報を得るには、現実的には不可能といえるものであった。 On the other hand, with recent advances in measurement technology, techniques have been developed for non-invasively observing the internal structure of the skin without accompanying skin resection. In vivo confocal laser microscope observation is one such technique, and it is possible to obtain a cross-sectional image inside the skin non-invasively. Attempts have been made to obtain skin internal information by applying this technique (for example, Patent Documents 1 to 5). However, such a method requires a special measuring device, and it is practically impossible to obtain counseling information related to beauty at a store, for example, at a store.
本発明は、上記事情に鑑みてなされたものであり、高価で複雑な機器を用いることなく、安価で簡便に、シミ発生部位の皮膚内部構造に関する情報を得ることができる方法を提供し、その情報を美容情報として有効活用することを目的とするものである。 The present invention has been made in view of the above circumstances, and provides a method capable of obtaining information on the internal structure of the skin of a spot-occurring site at low cost and without using expensive and complicated equipment. The purpose is to make effective use of information as beauty information.
本出願人は、シミの微細パターンと非侵襲的手法により得られた皮膚内部構造に関する情報を比較検討することにより、シミの微細パターンと皮膚内部構造に関して、関連性があることを見出し、本発明を完成させるに至った。即ち、本願発明は、シミ部位の画像情報を取得し、その画像情報に基いてシミの微細パターンを分類し、その分類に基いてシミ部位の皮膚内部構造に関する情報を推定することを特徴とする、シミ部位の皮膚内部構造推定法にある。また、本願第２の発明は、シミの微細パターンの分類が、下記(a)〜(d)であることを特徴とする、上記のシミ部位の皮膚内部構造推定法にある。 The present applicant has found that there is a relationship between the fine pattern of the skin and the internal structure of the skin obtained by comparing the information about the fine pattern of the skin and the information on the internal structure of the skin obtained by the noninvasive technique, and the present invention It came to complete. That is, the invention of the present application is characterized in that it acquires image information of a spot part, classifies a fine pattern of the spot based on the image information, and estimates information on the internal structure of the skin of the spot part based on the classification. In the method of estimating the internal structure of the skin of the spot site. The second invention of the present application is the above-described method for estimating the internal structure of the skin of a spot site, wherein the fine pattern classification of the spot is the following (a) to (d).
(a) 面状１（色素沈着が均一に分布している。）
(b) 面状２（色素沈着が均一に分布しているが、毛穴部分で色素沈着が抜けている。）
(c) 顆粒状（色素沈着が点状に分布している。）
(d) 網状（色素沈着が網目状の構造を有する。）
(a) Plane 1 (pigmentation is uniformly distributed)
(b) Planar 2 (Pigmentation is uniformly distributed, but pigmentation is missing at the pores.)
(c) Granular form (pigmentation is distributed in the form of dots)
(d) Reticulated (pigmentation has a reticulated structure)
さらに、本願第３の発明は、皮膚内部構造に関する情報が、下記(1)〜(5)であることを特徴とする、上記のシミ部位の皮膚内部構造推定法にある。 Furthermore, the third invention of the present application lies in the above-described method for estimating the internal structure of the skin of the spot site, wherein the information on the internal structure of the skin is the following (1) to (5).
(1) 角層の厚さ
(2) 表皮の厚さ
(3) 真皮乳頭層の高さ
(4) 真皮乳頭層の幅
(5) 真皮乳頭層の密度
(1) thickness of stratum corneum
(2) Epidermis thickness
(3) Height of the dermal papilla layer
(4) width of the dermal papilla layer
(5) Dermal papillary layer density
本発明によれば、大掛かりな測定機器を用いることなく、シミ部位の画像情報を取得し、その画像に基いてシミの微細発現パターンを分類するだけで、角層の厚さ、表皮の厚さ、真皮乳頭層の高さ、幅、密度といった皮膚内部構造に関する情報を推定することが可能となる。 According to the present invention, the thickness of the stratum corneum and the thickness of the epidermis can be obtained simply by acquiring the image information of the spot site without using a large-scale measuring device and classifying the fine expression pattern of the spot based on the image. It is possible to estimate information on the internal structure of the skin such as the height, width and density of the dermal papilla layer.
本発明は、シミ部位の画像情報に基いてシミの微細パターンを分類し、その分類に基き皮膚内部構造情報を推定することを特徴とするシミ部位の皮膚内部構造推定法です。シミ部位の画像情報を取得する方法は、シミ部位に関する光学情報を記録媒体に記録することができる手段であれば、如何なる手段でも用いることができ、例えば、光学カメラ、デジタルカメラ、ＣＣＤカメラ、ビデオカメラ、ビデオスコープ等が挙げられる。本発明では、シミ部位の画像情報に基いてシミの微細パターンを分類することから、シミ部位を拡大する機能を有する画像取得手段を用いるのが好ましい。本発明ではビデオマイクロスコープが特に好ましく用いられる。 The present invention is a method for estimating a skin internal structure of a spot site characterized by classifying a fine pattern of the spot based on image information of the spot site and estimating skin internal structure information based on the classification. As a method for acquiring the image information of the spot portion, any means can be used as long as it can record the optical information regarding the spot portion on the recording medium. For example, an optical camera, a digital camera, a CCD camera, a video Examples include cameras and video scopes. In the present invention, since the fine pattern of the spot is classified based on the image information of the spot part, it is preferable to use an image acquisition means having a function of enlarging the spot part. In the present invention, a video microscope is particularly preferably used.
次に、得られた画像情報に基いて、シミの微細パターンを分類する。分類の仕方としては特に限定されないが、皮膚内部構造に関する情報との間に何らかの相関が見出せるような分類とする必要がある。具体的なシミの微細パターン分類としては、以下のような特徴に基く(a)〜(d)の分類が挙げられる。 Next, the fine pattern of the stain is classified based on the obtained image information. Although it does not specifically limit as a classification method, It is necessary to set it as the classification which can find some correlation with the information regarding the skin internal structure. Specific examples of the fine pattern classification of spots include classifications (a) to (d) based on the following characteristics.
(a) 色素沈着が均一に分布している。・・・面状１
(b) 色素沈着が均一に分布しているが、毛穴部分で色素沈着が抜けている。・・・面状２(c) 色素沈着が点状に分布している。・・・顆粒状
(d) 色素沈着が網目状の構造を有する。・・・網状
(a) Pigmentation is uniformly distributed. ... Surface 1
(b) Although pigmentation is uniformly distributed, pigmentation is missing at the pores. ... Surface 2 (c) Pigmentation is distributed in the form of dots. ... Granular
(d) The pigmentation has a network structure. ... Reticulated
本発明における皮膚内部構造に関する情報とは、皮膚表面から表皮、真皮まで含めた皮膚構造体に係る情報全てを含む。本発明では、上記のシミの微細パターンから皮膚内部構造に係る情報を推定するために、予め皮膚内部構造に関する情報に基いて、上記のシミの微細パターンとの間を関連付けておく必要がある。 The information relating to the internal structure of the skin in the present invention includes all information relating to the skin structure including the skin surface to the epidermis and dermis. In the present invention, in order to estimate the information related to the internal structure of the skin from the fine pattern of the above-mentioned stain, it is necessary to associate the fine pattern of the above-mentioned stain in advance based on the information related to the internal structure of the skin.
皮膚内部構造に関する情報を得る方法としては特に限定されず、皮膚切除（バイオプシー）により得られたサンプルから皮膚標本を作製し、直接的に観察する方法を用いてもよいが、本発明のターゲットである健常女性の皮膚内部構造に関する情報を得る必要があることから、非侵襲的に皮膚内部構造に関する情報を得ることができる方法を採用するのが好ましい。非侵襲的手法により得られる具体的な皮膚内部構造に関する情報としては、共焦点レーザー顕微鏡観察から得ることができる、下記(1)〜(5)の情報が挙げられる（図１）。 The method for obtaining information on the internal structure of the skin is not particularly limited, and a method of preparing a skin specimen from a sample obtained by skin resection (biopsy) and directly observing it may be used. Since it is necessary to obtain information on the skin internal structure of a healthy woman, it is preferable to employ a method that can obtain information on the skin internal structure non-invasively. Information on the specific internal structure of the skin obtained by a non-invasive technique includes the following information (1) to (5) that can be obtained from confocal laser microscope observation (FIG. 1).
(1) 角層の厚さ（μｍ）
(2) 表皮の厚さ（μｍ）
(3) 真皮乳頭層の高さ（μｍ）
(4) 真皮乳頭層の幅（μｍ）
(5) 真皮乳頭層の密度（個／ｍｍ２）
(1) stratum corneum thickness (μm)
(2) Epidermis thickness (μm)
(3) Height of dermal papilla layer (μm)
(4) The width of the dermal papilla layer (μm)
(5) Density of the dermal papilla layer (pieces / mm 2 )
以下に、シミの微細パターン分類と皮膚内部構造に関する情報との関連付けの一例について記載する。 Below, an example of the correlation with the fine pattern classification | category of a stain and the information regarding a skin internal structure is described.
（被験者）
顔面にシミを有する健常女性２１名（平均年齢４６．９歳）を対象として実施した。
(subject)
The test was conducted on 21 healthy women (average age 46.9 years old) with spots on the face.
（シミ画像の取得とシミ微細パターンの分類）
シミ画像は、偏光フィルターを装着したビデオマイクロスコープ（CVM-7000、ウィルソン社製）を用いて、シミ部位を拡大してから画像として取り込みを行った。次いで、取得した画像情報をもとにシミの微細パターンを、上記に従って(a)面状１、(b)面状２、(c)顆粒状、(d)網状のいずれかに分類した。その結果、各微細パターンの構成は、面状１が１０例、面状２が６例、顆粒状が２例、網状が３例であった。シミの各微細パターンの画像例を図２〜図５に示す。
(Acquisition of spot image and classification of spot fine pattern)
The stain image was captured as an image after enlarging the stain portion using a video microscope (CVM-7000, manufactured by Wilson) equipped with a polarizing filter. Then, based on the acquired image information, the fine pattern of the stain was classified into any one of (a) Plane 1, (b) Plane 2, (c) Granule, and (d) Mesh. As a result, the configuration of each fine pattern was 10 in the surface shape 1, 6 in the surface shape 2, 2 in the granular shape, and 3 in the net shape. Examples of images of each fine pattern of spots are shown in FIGS.
（皮膚内部構造に係る情報）
シミ部位における皮膚内部構造に係る情報は、In vivo 共焦点レーザー顕微鏡（Vivascope1000、Lucid社製）を用いて、皮膚表面から真皮に至るＺ軸方向における深度を変化させた水平断面像をもとにして、(1)角層の厚さ、(2)表皮の厚さ、(3)真皮乳頭層の高さ、(4)真皮乳頭層の幅、(5)真皮乳頭層の密度に関する情報を算出した。また、シミ部位の計測と同時に、正常部位の計測も行い比較対照とした。尚、顔面の正中線を基準としてシミ部位の左右対称部位を正常部位とした。
(Information on skin internal structure)
Information on the internal structure of the skin at the spot site is based on a horizontal cross-sectional image with varying depth in the Z-axis direction from the skin surface to the dermis using an in vivo confocal laser microscope (Vivascope1000, manufactured by Lucid). Information on (1) stratum corneum thickness, (2) epidermis thickness, (3) dermal papillary layer height, (4) dermal papillary layer width, and (5) dermal papillary layer density information. did. In addition, the normal site was measured simultaneously with the measurement of the spot site and used as a comparative control. In addition, the left-right symmetric part of a spot part was made into the normal part on the basis of the midline of the face.
（シミ微細パターンと皮膚内部構造の関連付け）
共焦点レーザー顕微鏡観察から得られた上記(1)〜(5)の皮膚内部情報を、シミ微細パターンに基いて対比させた結果を図６〜図１０に示す。
(Association of fine stain pattern and internal structure of skin)
FIGS. 6 to 10 show the results of comparing the internal skin information (1) to (5) obtained from the confocal laser microscope observation based on the fine stain pattern.
角層の厚さ（図６）に関しては、正常部位と比較して、顆粒状のシミ微細パターンを有する色素沈着部位において角層の厚さが増加する傾向が認められた。 Regarding the stratum corneum thickness (FIG. 6), the stratum corneum thickness tended to increase at the pigmentation site having a granular spot fine pattern as compared with the normal site.
表皮の厚さ（図７）に関しては、いずれのシミ微細パターンにおいても正常部位と比較して、表皮の厚さの増加が認められた。特に顆粒状のシミ微細パターンを有する色素沈着部位は、正常部位の２倍の表皮厚であり、顕著な表皮厚の増加であった。 Regarding the thickness of the epidermis (FIG. 7), an increase in the thickness of the epidermis was observed in any of the spot fine patterns as compared with the normal site. In particular, the pigmentation site having a granular spot fine pattern had a skin thickness twice that of the normal site, and a marked increase in the skin thickness.
真皮乳頭層の高さ（図８）については、面状１と顆粒状のシミ微細パターンにおいて、高さが増加する傾向が認められた。 Regarding the height of the dermal papilla layer (FIG. 8), a tendency for the height to increase was observed in the planar 1 and granular stain fine patterns.
真皮乳頭層の幅（図９）については、面状１において幅が増加する傾向が認められた。 Regarding the width of the dermal papilla layer (FIG. 9), a tendency for the width to increase in the planar shape 1 was observed.
真皮乳頭層の密度（図１０）については、いずれのシミ微細パターンにおいても正常部位と比較して、真皮乳頭層の密度の上昇が認められた。特に網状微細パターンを有する色素沈着部位において顕著な、顆粒状シミ微細パターンを有する色素沈着部位において極め
て顕著な密度の上昇が認められた。
Regarding the density of the dermal papilla layer (FIG. 10), an increase in the density of the dermal papilla layer was observed in all the fine stain patterns compared to the normal site. In particular, a remarkable increase in density was observed at the pigmentation site having the granular spot fine pattern, which was remarkable at the pigmentation site having the net-like fine pattern.
以上の結果から、正常部位と比較した場合の各シミ微細パターンにおける変化の特徴を下記表１にまとめて示す。(1)角層の厚さ、(2)表皮の厚さ、(3)真皮乳頭層の高さ、(4)真皮乳頭層の幅、(5)真皮乳頭層の密度に関する情報に関して、正常部位と比較してシミの微細パターン毎に特徴的な変化を示すことが明らかとなった。 From the above results, the characteristics of the change in each spot fine pattern when compared with the normal site are summarized in Table 1 below. Normal site for information on (1) stratum corneum thickness, (2) epidermis thickness, (3) dermal papillary layer height, (4) dermal papillary layer width, (5) dermal papillary layer density It became clear that the characteristic change was shown for every fine pattern of a spot compared with.
（表１）
―――――――――――――――――――――――――――――――――――
シミの微細パターン分類
皮膚内部構造情報 ――――――――――――――――――――
面状１ 面状２ 顆粒状 網 状
―――――――――――――――――――――――――――――――――――
(1)角層の厚さ → → ↑ →
(2)表皮の厚さ ↑↑ ↑↑ ↑↑↑ ↑↑
(3)真皮乳頭層の高さ → → ↑ ↑
(4)真皮乳頭層の幅 ↑ → → →
(5)真皮乳頭層の密度 ↑↑ ↑↑ ↑↑↑↑ ↑↑↑
―――――――――――――――――――――――――――――――――――
→：変化なし。↑：増加の傾向が認められる。↑↑：増加が認められる。
↑↑↑：顕著な増加が認められる。↑↑↑↑：極めて顕著な増加が認められる。
(Table 1)
―――――――――――――――――――――――――――――――――――
Skin fine pattern classification Skin internal structure information ――――――――――――――――――――
Plane 1 Plane 2 Granule Net ---------------
(1) Thickness of stratum corneum → → ↑ →
(2) Epidermis thickness ↑↑ ↑↑ ↑↑↑ ↑↑
(3) Height of dermal papilla layer → → ↑ ↑
(4) Width of dermal papilla layer ↑ → → →
(5) Density of the dermal papilla layer ↑↑ ↑↑ ↑↑↑↑ ↑↑↑
―――――――――――――――――――――――――――――――――――
→: No change. ↑: An increasing trend is observed. ↑↑: Increase is recognized.
↑↑↑: Significant increase is observed. ↑↑↑↑: Significant increase is observed.
以上の結果をもとに、シミ部位の画像情報をビデオマイクロスコープのような手段により取得し、シミ微細パターンを(a)面状１、(b)面状２、(c)顆粒状、(d)網状に分類することにより、その分類に基いて(1)角層の厚さ、(2)表皮の厚さ、(3)真皮乳頭層の高さ、(4)真皮乳頭層の幅、(5)真皮乳頭層の密度という皮膚内部構造に関して、正常部位と比較してどのように変化をしているかについて予測し、美容情報として利用することが可能である。 Based on the above results, the image information of the spot site is obtained by means such as a video microscope, and the spot fine pattern is (a) plane 1, (b) plane 2, (c) granule, ( d) By classifying into a mesh, (1) stratum corneum thickness, (2) epidermis thickness, (3) dermal papillary layer height, (4) dermal papillary layer width, (5) With respect to the internal structure of the skin, the density of the dermal papilla layer, it is possible to predict how it is changing compared to the normal site and use it as beauty information.
本発明は、化粧品販売店等におけるカウンセリング販売等で利用することができる。即ち、店頭においてビデオマイクロスコープによって顧客のシミ画像を取得してシミの微細パターンを分類する。その分類から表１に従ってシミ部位の内部構造情報を予測し、その情報をカウンセリング情報として利用する。例えばシミ微細パターンが顆粒状に分類された場合には、そのシミ部位では表皮が厚くなり、真皮乳頭層が極めて複雑化していることが予測されるため、美白製剤として、表皮浸透性がより高い製剤を推奨する。 The present invention can be used for counseling sales at cosmetic stores and the like. That is, a spot image of a customer is acquired by a video microscope at the store, and the fine pattern of the spot is classified. Based on the classification, the internal structure information of the spot site is predicted according to Table 1, and the information is used as counseling information. For example, if the fine stain pattern is classified as granular, it is predicted that the epidermis will be thick and the dermal papilla layer will be extremely complex at the spot, so that it has higher epidermal permeability as a whitening preparation. Recommend formulation.
本発明のシミ部位の皮膚内部構造推定法を用いることにより、化粧品販売店のカウンターのような場所においても、ビデオマイクロスコープのような比較的簡便な測定機器によりシミ部位の画像情報を取得するだけで、皮膚内部の情報を得ることができる。そのため化粧品のカウンセリング販売において、顧客の皮膚内部状態に適合した最適の化粧品を推奨・提供することが可能となる。 By using the method for estimating the skin internal structure of a spot site according to the present invention, image information of the spot site can be obtained only with a relatively simple measuring device such as a video microscope even in a place such as a counter of a cosmetics store. Thus, information inside the skin can be obtained. For this reason, in cosmetics counseling sales, it is possible to recommend and provide optimal cosmetics suitable for the skin condition of the customer.
１ 角層の厚さ
２ 表皮の厚さ
３ 真皮乳頭層の高さ
４ 真皮乳頭層の幅
1 Thickness of the stratum corneum 2 Thickness of the epidermis 3 Height of the dermal papilla layer 4 Width of the dermal papilla layer
Claims (3)
(a) 面状１（色素沈着が均一に分布している。）
(b) 面状２（色素沈着が均一に分布しているが、毛穴部分で色素沈着が抜けている。）
(c) 顆粒状（点状に色素沈着が分布している。）
(d) 網状（網目状の構造を有する。） The method for estimating a skin internal structure of a spot site according to claim 1, wherein the classification of the fine pattern of the spot is the following (a) to (d).
(a) Plane 1 (pigmentation is uniformly distributed)
(b) Planar 2 (Pigmentation is uniformly distributed, but pigmentation is missing at the pores.)
(c) Granules (pigmentation is distributed in the form of dots)
(d) Reticulated (has a reticulated structure)
(1) 角層の厚さ
(2) 表皮の厚さ
(3) 真皮乳頭層の高さ
(4) 真皮乳頭層の幅
(5) 真皮乳頭層の密度 The method for estimating a skin internal structure of a spot site according to claim 1 or 2, wherein the information on the skin internal structure is the following (1) to (5).
(1) thickness of stratum corneum
(2) Epidermis thickness
(3) Height of the dermal papilla layer
(4) width of the dermal papilla layer
(5) Dermal papillary layer density
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