JP2009256364A - Method and composition for improving health state of fertilizing capacity of male and female animal and human - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a combination of biologically effective compounds for enhancing the fertilizing capacity of males and females. <P>SOLUTION: Provided is a pharmaceutical composition containing a combination of active amounts of vitamins C and E, selenium, ferulic acid, zinc and vitamin B. A specifical example of the pharmaceutical composition contains 20-80 wt.% L-carnitine, 5-30 wt.% vitamins C and E, 0-10 wt.% coenzyme Q10, 0.001-1 wt.% selenium, 0.2-20 wt.% ferulic acid, 0.1-2 wt.% zinc and 0.001-1 wt.% vitamin B. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to methods and compositions for improving fertility health.

  Pregnancy difficulties have been experienced due to delayed childbirth, unhealthy eating, and tobacco, caffeine, alcohol, drug use and environmental pollutants.

  There is a need for pharmaceuticals that improve the fertility of both women and men.

-Summary of invention-
The present invention provides biologically effective combinations of compounds to promote male and female fertility. This combination includes nutrients that are effective for fertility health. All ingredients were studied individually to measure their individual effects. The present invention provides the first product for synergistically combining these ingredients in female and male formulations.

  About 15% of couples in the United States have problems getting their children pregnant. In about one third of these cases, men have azoospermia, and in one third, women have fertility problems, and the other one third is the fertility of men and women. This is due to a combination of problems or unknown causes. In many of these cases, the cause of infertility is treatable.

  Nutritional changes and lifestyle changes may be the first steps to increase the chance of pregnancy. Smoking, caffeine, drug and alcohol consumption, environmental toxins, and stress are associated with infertility in men and women.

  The reproductive organs are very susceptible to free radicals or oxidative damage from environmental toxicants and natural aging. A balanced nutritional diet and dietary supplements rich in antioxidants can help some recovery of the damage. Other nutrients such as L-carnitine, vitamin B and zinc are important for spermatogenesis and metabolism. In women, hormonal balance is important for the expression of monthly ovulation and corpus luteum (follicles that release progesterone after egg release to regulate the uterus for implantation).

  These and further objects and features of the invention and other objects and features will become apparent in the present disclosure, including the specification with claims.

-Detailed description of preferred embodiments-
The present invention provides a useful biologically effective combination of compounds to promote female fertility. The present invention is a science for women that improves infertility by contributing to the regulation of the menstrual cycle and correction of hormonal instability (luteal dysfunction) without increasing the likelihood of multiple pregnancy associated with drug therapy. An effective herb / nutrient mixture. A combination of amino acids, herbs, vitamins and minerals can help with many deficiencies that improve overall health and reduce fertility.

  The herb, Carrot Box (Chestberry), enhances female hormone balance by increasing luteinizing hormone and progesterone release, thereby increasing ovulation frequency. Antioxidants, green tea, vitamin E and selenium improve overall sexual and reproductive health. The amino acid L-arginine stimulates the reproductive organs by improving blood circulation. Folic acid, vitamins B6 and B12, iron, zinc and magnesium help to promote female fertility.

  The present invention provides a useful biologically effective combination of compounds to promote male fertility. Sperm are very susceptible to free radicals or oxidative damage from environmental toxicants and natural aging. Vitamin C and E, green tea with or without coenzyme Q10 and selenium, are all potential antioxidants that help improve sperm count and quality. Ferulic acid, an antioxidant contained in Dong Quai, also improves sperm quality. Zinc and vitamin B (B6, B12 and folic acid) are important nutrients for hormone metabolism, sperm formation and motility in the male reproductive system. The amino acid L-carnitine promotes normal sperm formation. L-carnitine fumarate is preferred. L-carnitine tartrate can be used.

  The present invention provides the synergistic effect of the combination.

  Two dietary supplements in male and female prescriptions are beneficial for men and women. Preferably, the different combinations are taken by both couples between the ages of women 21-46. The different combinations are beneficial in becoming pregnant, even if not very successful, for couples who have tried for a period of 6 months or more to 3 years or less. Preferably, patients take 2 to 4 capsules per day for a different prescription for 3 months.

The preferred range of combinations is in weight percent:
Female prescription ingredients Minimum% Maximum%
Carrot box (chest berry) 2 10
L-Arginine 40 60
Green tea 5 20
Vitamin E 5 20
Selenium 0.01 1
Vitamin B6, B16 0.01 1
Folic acid 0.01 1
Iron 0.1 5
Magnesium 10 40
Zinc 0.1 5

Male prescription ingredients Minimum% Maximum%
L-carnitine 40 70
Ferulic acid in Donquay 0.01 10
Vitamin C and E 10 40
Coenzyme Q10 0 5
Selenium 0.01 1
Zinc 0.1 10
Vitamin B 0.001 1

Female and male prescription tolerances are:
Female prescription ingredients Minimum% Maximum%
Carrot box (chest berry) 1 20
L-Arginine 20 70
Green tea 0 30
Vitamin E 0.01 30
Selenium 0 2
Vitamin B6, B16 0 2
Folic acid 0 2
Iron 0 7
Magnesium 0 50
Zinc 0 10

Male prescription ingredients Minimum% Maximum%
L-carnitine 20 80
Ferulic acid in Donquay 0 20
Vitamin C and E 0.01 40
Coenzyme Q10 0 10
Selenium 0 3
Zinc 0 15
Vitamin B 0 5

Examples of useful formulations are in weight percent:
Female prescription ingredient Carrot Box (Chestberry) 5
L-Arginine 50
Green tea 11
Vitamin E 11
Selenium 0.6
Vitamin B6, B16 0.38
Folic acid 0.02
Iron 1
Magnesium 20
Zinc 1
100%

Male prescription ingredients% weight L-carnitine 60
Ferulic acid in Donquay 6
Vitamins C and E 30
Coenzyme Q10 1
Selenium 0.6
Zinc 2
Vitamin B 0.4
100%

  In the following, Examples 1, 2, and 3 provide the preferred range of combinations for male prescriptions in weight percent:

Ingredient Min% Max%
L-carnitine 40 70
Ferulic acid in Donquay 0.1 10
Vitamin C and E 10 40
Green tea 1 20
Selenium 0.01 1
Zinc 0.1 10
Vitamin B 0.001 1

Ingredient Min% Max%
L-carnitine 20 80
Ferulic acid in Donquay 0 20
Vitamin C and E 0.01 40
Green tea 0 30
Selenium 0 3
Zinc 0 15
Vitamin B 0 5

One example of a useful formulation is in weight percent:
Ingredient% Weight L-carnitine 50.4
Donquay (.190 ferulic acid) 8
Vitamins C and E 23
Green tea 17
Selenium 0.1
Zinc 1.3
Vitamin B 0.2
100%

  While this invention discloses references to specific embodiments, it is believed that modifications and variations of this invention can be practiced without departing from the scope of this invention as set forth in the claims. It is done.

Claims (21)

  A pharmaceutical composition having male fertility promoting activity, comprising an effective amount of vitamin C and E, selenium, ferulic acid, zinc and vitamin B in combination.   The pharmaceutical composition according to claim 1, further comprising an effective amount of L-carnitine, which is another component, in the combination. The ingredients are by weight:
20 to 80% L-carnitine,
5-30% vitamins C and E,
0 to 10% coenzyme Q10,
0.001 to 1% selenium,
0.2 to 20% ferulic acid,
0.1 to 2% zinc, and 0.001 to 1% vitamin B
The pharmaceutical composition according to claim 2, wherein The ingredients are by weight:
10 to 80% L-carnitine,
5-50% vitamins C and E,
0 to 15% coenzyme Q10,
0.001 to 1% selenium,
0.2 to 20% ferulic acid,
0.1 to 15% zinc and 0.001 to 1% vitamin B
The pharmaceutical composition according to claim 1, wherein The ingredients are by weight:
60% L-carnitine,
25% vitamins C and E,
Donquay with 8% ferulic acid,
5% zinc and vitamin B,
The pharmaceutical composition according to claim 1, characterized in that it is a proportion of 2% coenzyme Q10 and 0.6% selenium.   A pharmaceutical composition having fertility promoting activity for males, comprising green tea, vitamin C, vitamin E or an antioxidant containing selenium, L-carnitine, ferulic acid in donquay, vitamins B6, B12, folic acid, and zinc A pharmaceutical composition characterized in that it contains an effective amount of the ingredients in combination. The ingredients are by weight:
Antioxidants containing 5-50% green tea, vitamin C, vitamin E or selenium,
L-carnitine, which is 10 to 80% amino acids,
0 to 1% ferulic acid in Donquay,
0 to 1% vitamin B6, B12 and folic acid,
The pharmaceutical composition according to claim 6, characterized in that it is in a proportion of 0 to 10% zinc. The ingredients are by weight:
Antioxidants containing 20-50% green tea, vitamin C, vitamin E or selenium,
L-carnitine, which is 40-80% amino acids,
0.01-1% ferulic acid in Donquay,
0.003 to 1% vitamin B6, B12 and folic acid,
The pharmaceutical composition according to claim 6, characterized in that it is in a proportion of 1 to 10% zinc. A pharmaceutical composition having male fertility promoting activity,
By weight:
Antioxidants containing 5-50% green tea, vitamin C, vitamin E or selenium,
L-carnitine, which is 10 to 80% amino acids,
0.01-1% ferulic acid in Donquay,
0.01 to 1% vitamin B6, B12 and folic acid,
A pharmaceutical composition comprising an effective amount of an ingredient in a combination of from 0.1 to 10% zinc.   A pharmaceutical composition having male fertility promoting activity, comprising an effective amount of vitamin C and E, selenium, ferulic acid, folic acid and vitamin B in combination.   The pharmaceutical composition according to claim 10, further comprising an effective amount of L-carnitine fumarate as another component in the combination. The ingredients are by weight:
20 to 80% L-carnitine fumarate,
5-30% vitamins C and E,
1 to 30% green tea,
0.001 to 1% selenium,
2-20% donkuai,
0.1 to 2% zinc and 0.001 to 1% vitamin B
The pharmaceutical composition according to claim 11, wherein The ingredients are by weight:
20 to 80% L-carnitine fumarate,
5-30% vitamins C and E,
0.1 to 30% green tea,
0.001 to 1% selenium,
2-20% donkuai,
0.1 to 2% zinc and 0.001 to 1% vitamin B
The pharmaceutical composition according to claim 11, wherein The ingredients are by weight:
10 to 80% L-carnitine,
5-50% vitamins C and E,
1 to 30% green tea,
0.001 to 1% selenium,
0.2 to 20% of donkuai,
0.1 to 5% zinc and 0.001 to 1% vitamin B
The pharmaceutical composition according to claim 10, wherein The ingredients are by weight:
50% L-carnitine,
23% vitamins C and E,
8% donkuai,
11. A pharmaceutical composition according to claim 10, characterized in that it is in a proportion of 2% zinc and vitamin B and 17% green tea.   New nutritional supplements to enhance male fertility health, antioxidants to improve overall sexual and reproductive health, green tea, vitamin C, vitamin E and selenium, male fertility A nutritional supplement comprising L-carnitine, vitamins B6 and B12, and zinc, which are amino acids for promoting aging.   A method for producing a substance for promoting male fertility health, wherein the method comprises L-carnitine, donkuai, green tea, vitamins B6, B12, C, E, folic acid, zinc and selenium. Producing a supplement.   The dietary supplement further comprises 50% L-carnitine, 17% green tea, 8% donkuai, 23% vitamins C and E, 1% zinc, and less than 1% selenium, vitamin B6 by weight percent. 18. The method according to claim 17, comprising B12 and folic acid as components.   A method for producing a substance for promoting male fertility health, wherein said method comprises 10 to 80% amino acid L-carnitine by weight, 5 to 50% green tea, vitamin C, Effectiveness of antioxidants containing vitamin E or selenium, 0.1 to 10% zinc, 0.01 to 1% ferulic acid, and 0.01 to 10% vitamin B6, B12 and folic acid Producing a nutritional supplement having a male fertility-promoting activity comprising an amount in combination.   Oxidation containing a green supplement, green tea, vitamin C, E or selenium that is suitable for use as a treatment to promote male fertility, wherein the nutritional supplement has male fertility promoting activity A nutritional supplement comprising an effective amount of an inhibitor, L-carnitine, donkuai, vitamins B6, B12, folic acid and zinc in a combination.   A method for producing a substance that promotes male fertility by inoculation, wherein said method comprises antioxidants, green tea, vitamin C, vitamin E and selenium for improving overall sexual and reproductive health, L-carnitine, which is an amino acid for improving sperm quality, and fertilic acid, vitamin B6, B12, folic acid and zinc in donquay for promoting fertility in men, how to.