JP2009137981A - Method for feeble energy treatment to fuscopia oblique(fr.) aoshima medicine, and snow-broth and other food and drink product for health - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To produce a medicine used for injection, intravenous drip, etc., of an active ingredient originated from Fuscopia oblique(Fr.) Aoshima and to impart activity. <P>SOLUTION: Medicine used for injection, intravenous drip, etc., solid preparation such as suppository or tablet, etc., contains extract of the Fuscopia oblique(Fr.) Aoshima in high purity from which ashes, especially potassium and sodium compounds, are removed, and the medicine comprising the extract in which the ashes are not subjected to removal and contained as an active ingredient and having therapeutic activity and acting to a wide variety of symptoms, are subjected to the feeble energy treatment. The medicines have various physiological activity such as an anti-virus activity to AIDS, influenza, etc., antitumor activity, immunopotentiation activity, etc. The treatment with feeble energy such as exposure to far-infrared rays and anions, treatment with electrolysis of highly functional water, snow-broth, groundwater, can enhance the pharmacological effect of the medicines. The excellent food and drink for health is obtained. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

Detailed Description of the Invention

TECHNICAL FIELD OF THE INVENTION

The present invention relates to the use of an active ingredient extracted from birch salmon as an injectable solution, a drip solution, a wide variety of other drugs such as solids or powders, and health drink products such as drinks, health foods, noodles, and soup foods. Is. In particular, in terms of use as injections and infusions, active ingredients extracted from birch moss and purified to high purity are used as liquids, but other drugs, drinks, and health foods have high purity. Even if it is not of high purity, the extract active ingredient of birch salmon can be used. Here, the health food and drink product is purified to a high purity, and the limited specific range in which the active ingredient of birch salmon to which weak energy is applied is used as food. Specifically, the high-purity active ingredient is used as an injectable solution that can be directly injected into blood vessels or muscles by removing or at least reducing unnecessary components such as potassium and sodium from the extract of birch oyster mushroom. . Such high-purity active ingredients have a good effect on the digestive system when taken orally. In general, the active component of birch extract according to the present invention has antiviral activity against viruses such as AIDS virus and influenza virus, antibacterial activity against O-157, antimutagenic activity against mutagens such as benzopyrene, and anticancer activity against cancer cells. Tumor activity, immune enhancement activity, and many other useful physiological activities described below.

Background of the Invention

A kind of mushrooms, birch anatake [scientific name Fuscopiaoblique (Fr.) Aoshima], has antitumor activity (Japanese Patent Application No. 1-1114665), anti-AIDS virus activity (Japanese Patent Application No. Hei 8-23208, etc.) and antimutagenicity (Special It has already been confirmed by the present inventor that the present invention has an activity such as Application No. 8-145218), and its utilization technology has been developed. Until now, however, the birch anatake extract component has been mainly taken orally as, for example, health foods or drugs. However, no attempt has been made to put those active ingredients directly into the blood, for example by injection. However, it can be expected that the application range in the medical field will be greatly expanded for a patient who cannot take the active ingredient of birch extract orally if a preparation in the form of a syringe, an infusion solution, or a suppository is made. In addition, as an oral or drink preparation / health food for birch extract, there is no particular problem for healthy people even with conventional extracts, but patients with gastrointestinal diseases such as duodenal ulcers, liver cancer, stomach cancer, and rectum. For post-surgical patients such as cancer and patients such as hemorrhoids, conventional high-purity components rather than extracted components can be taken with little irritation. If weak energy is applied, the pharmacological function is further improved.

According to the study of the present inventor, the main cause of preventing the invasion or infusion of birch extract into blood or muscle and causing undesired irritation to the living body is contained in the birch extract. Ashes were confirmed. If at least these ash components can be removed effectively, it will be clear that the birch extract can be used as an extremely useful injection, drip solution, suppository, intracorporeal agent, or as a less irritating oral or drink. Became.

Problems to be solved by the invention

Therefore, the present invention is capable of removing or reducing unnecessary ash, and further reducing or removing other unnecessary components in some cases, and the human body can be directly injected into the blood or muscle of an animal. The first problem is to provide a liquid preparation containing a high-purity birch extract, and secondly, a drug that is used with particular attention to physiological activities such as antiviral activity and immune enhancing activity including AIDS. Providing, and thirdly, foods such as so-called drinks, health foods, noodles, and soy sauces, which contain high-purity and non-high-purity, active ingredients for the extraction of birch salmon and contribute to the maintenance and promotion of health widely (Including the use of counties). A fourth object of the present invention is to give weak energy to the birch extract to further enhance its activity. Since the present application has been divided and filed in order to launch the fourth weak energy, the text cannot be changed significantly. I am convinced that there will be an era when technology that absorbs weak energy such as snow water as well as material power or provides weak energy is another leading role. When weak energy is applied to the active ingredient liquid of birch moth, snow water, etc., it becomes delicious, strengthening the muscular strength of humans and animals and increasing physiological activity, the value of the effect of SOD-like substance and the efficacy of anti-AIDS virus of birch moth Increase. In the development and use of birch, there is a situation where the weak energy of the present application is disclosed and there are various explanations.

Means for solving the problem

For this reason, the present invention provides molecular sieves (for example, gel filtration, gel chromatography, thin layer) for high-purity birch extract from ash extract, particularly potassium compounds and sodium compounds, and other unnecessary components as required. A preparation / product is produced using a high-purity extract body removed or at least reduced by a technique such as chromatography as an active ingredient. The form of the preparation is preferably a solution in an ampoule or other container, and is preferably used as an injection solution or an infusion solution, but can also be used as a solid agent such as a suppository or an in-vivo insert (detailed later). . In addition, to obtain tablets or granules in the form of tablets for oral use, it is possible to use a birch extract, which does not go through an ash removal step, or to use a high-purity component from which ash has been removed. In addition, sweetener, salt, and other flavoring agents may be added to the solution or powder of the extract of birch bamboo shoots to form a form that should be widely referred to as “healthy food products” such as drinks and health foods. The aspect of the present invention as an antiviral agent or immunopotentiator can be widely realized as liquid goods such as injections and infusions, orally administered drugs, and in the form of health foods and drinks. it can.

The birch extract component according to the present invention can be fractionated into various fractions having different molecular weights using techniques such as gel filtration. Briefly describing the procedure of extraction and fractionation, in one specific example, the extract was obtained by hot water extraction of birch natto natural nuclei (with about 6 times the water of the solid content) and freeze-drying the extract. 100 mg of the dry powder is dissolved in 10 cc of distilled water, and the aqueous solution is purified by removing dust by centrifugation, then put into a column and fractionated by gel filtration.
The molecular weight for each fraction shown in Table 1 was obtained by such a procedure.
In the gel filtration which obtained the data of Table 1, blue dextran (molecular weight 1,000.000) and ferritin (molecular weight 450,000) were used as molecular weight markers. Myoglobin (molecular weight 17,800) and DNP-L-alanine (molecular weight 255) were used. In addition to natural products, birch salmon can achieve the same effect by using artificially cultivated mycelium (cultured in a solid medium or liquid medium).
In addition to extraction with hot water, extraction with an alcohol or other solvent can be used for extraction of the active ingredient.

A test was conducted to examine the anti-AIDS virus activity corresponding to the molecular weight of each fraction shown in Display 1 obtained by gel filtration. When non-infected cells of healthy subjects (Molt 4 / c 18 cells) and cells infected with AIDS virus (Molt 4 / c HIV III B) are co-cultured, non-infected cells adhere and fuse around the infected cells. Giant cell formation occurs. This is a form of AIDS growth. It was confirmed that the addition of birch extract (aqueous solution) to this co-culture system had the effect of controlling the formation of giant cells. Briefly, the test method is to mix and dilute infected cells and non-infected cells at a ratio of 1: 1 (1 × 10 ⁶ : 1 × 10 ⁶ ), and add each portion of the birch extract to this co-culture system. The fraction components were added at a concentration of 10 μl / ml, cultured for 24 hours, and then the diameter of the cells was measured with a multisizer. Those with a size of 20 μm or more were regarded as giant cells. Was the rejection rate%. The results are shown in the column of% rejection in Table 1.

The blocking rate in Table 1 will be described. Anti-AIDS activity is observed over a wide range in each fraction having a molecular weight of 450,000 (fraction 31) or less. A blocking rate of 60 to 100% is achieved over a molecular weight of 220,000 (fraction 34) to a molecular weight of 10,000 (fraction 47). In particular, the molecular weight 62,000 (fraction 39) is 100%, the molecular weight 50,000 (fraction 40) is 80.49%, the molecular weight 40,000 (fraction 41) is 95.29%, the molecular weight 30,000 ( A very high potency of 89.30% was observed in fraction 42). The molecular weight is 11,000 (fraction 46), 83.14%, and the molecular weight is 10,000 (fraction 47), 65.35%. Furthermore, even with a molecular weight of 10,000 or less, the AIDS rejection rate is 68.16% at a molecular weight of 8,000 (fraction 48), and the high rejection rate is 86.39% at a molecular weight of 2,000 (fraction 55). Is noteworthy. Furthermore, achieving an AIDS inhibition rate of 45.87% at a lower molecular weight of 190 (fraction 68) indicates that the birch extract is still active at a relatively low molecular weight. In the test of Table 1, the activity was not recognized at a molecular weight of 450,000 or more, but different results can be obtained by changing the concentration of the test solution (birch extract). For example, a 100% inhibitory activity test (detecting the minimum effective concentration that inhibits the growth of AIDS virus by 100%) with the concentration of the test solution being several times the concentration of the test in Table 1 (for example, 15.6-65.2 μl) In the test), it was confirmed that extract components having a molecular weight of 600,000 to 1,000,000 or more are also effective. Thus, the birch extract of the present invention is effective in a narrow molecular weight range normally found in other substances, and is characterized by being widely distributed in an amorphous form in which the molecular weight range of the active ingredient is not particularly limited. It is. From this point of view, the birch extract of the present invention does not individually extract active ingredients corresponding to various molecular weights, but rather extracts all the molecular weights (for example, from higher than 1 million to 100 or less small molecules). It can be said that it is reasonable to use it comprehensively. As described later, the birch extract is caused by the comprehensive inclusion of various components having various molecular weights, including diseases caused by retroviruses including AIDS virus and other viruses.

However, from another point of view, a component having a very high molecular weight may not be preferable, for example, in order to make absorption into a body tissue more effective. In such a case, it can be said that it is more appropriate to select a portion having a relatively low molecular weight and use only an extract having a molecular weight of 10,000 or less or a molecular weight of 8,000 or less. In particular, since a substance having a molecular weight of 5,000 or less (fraction 50 or less) is most readily absorbed by the gastrointestinal tract, it is also a method to select and use only this range. In addition, as described above, the present birch extract of moss contains ash as described above. Therefore, when trying to obtain a high-purity extract that is harmless to blood and muscle, as described below, It is necessary to go through a removal process.

Next, various experiments leading to the establishment of the present invention will be described.
Combustion experiment for confirming ash content As a basic experiment (1) of the present invention, the ash composition of birch was examined. Specifically, the experiment was conducted by using dried dried birch (natural product) and burning it. Burning dried dried birch leaves will continue to smolder until they are completely burned out. The remaining ash is soft with a greenish pale blue color and is hygroscopic. The amount of this ash was on average about 13% with respect to the dry weight of the birch starting material. Of these, more than 50% (equivalent to about 7% of the starting material) was potassium and sodium. This is because, compared to well-known mushrooms such as shiitake mushrooms, 4.7% of the dry fruit body weight is ash, so birch salmon has a particularly large amount that is not found in normal mushrooms. It was confirmed that 2.6 times as much ash was contained. Table 2 below shows the average ash content confirmed by several experiments.

Table 2

Cation Composition (wt%) anionic composition _{(wt%) Mn 2 O 3 1.25P 2} O 3 8.79CuO0.004SO 4 0.05 ZnO 0.056 CO 2 40.85 Na 2 09.60 K 2 O42 .70 MgO 2.39 CaO 1.92Al ₂ O ₃ O0.16Fe ₂ O ₃ 0.16SiO ₂ 1.80SO ₄ 5.80 As can be seen from Table 2, K among the ash remaining after burning birch salmon ₂ O is _{42.7% N} a. 2O is also 9.6%, 50% or more ash is potassium and sodium compounds combined both. Both of these compounds not only have the physiological activity expected in the present invention, but are also unsuitable for direct injection into blood and muscle, and oral use is also an unnecessary substance that irritate the gastrointestinal tract. It should be. The experiment was conducted using natural birch moss, but the tendency of the ash composition to contain a large amount of sodium and potassium is the same in the case of cultivated birch moss (solid medium and liquid medium). Therefore, in the present invention, natural products and cultures of birch moss are equivalent.

Composition analysis of the extract,
Next, as a basic experiment (2), the scientific organization in the hot water extract of the birch was taken. Concentrated hot water extract of birch anatake and analyzed the chemical composition of ash in this, the proportion of total ash was the highest with potassium being 63.2%, followed by sodium 13.1%, magnesium 1.83% It was confirmed that In this manner, it was found that the hot water extract contains a large amount of potassium compounds and sodium compounds in the same manner as the ash composition when the birch was burned. The results are shown in Table 3. It is clear from this that potassium compounds and sodium compounds should be removed from the birch extract to obtain high purity active ingredients. Here again, as in the combustion experiment, the natural birch and artificial culture birch are equivalent.

Table 3

_Wt% Na 2 for oxide name total ash _{O13.10 K 2 O63.20 Mn 2 O3 1.05} MgO1.83 CaO traces Fe ₂ O ₃ 0.39 SiO ₂ 1.66

From the above basic experiments, in order to prepare a liquid agent that can be directly inserted into the bloodstream or muscle, for example, an injection solution, not only general non-active impurities are removed, but also at least K ₂ to obtain a high-purity birch salmon active ingredient. It has been found necessary to remove or reduce O and Na ₂ O. Of course, other impure components need to be removed if there is a problem, but K ₂ O and Na ₂ O are contained in a particularly large amount, and it is desired in the present invention. Since there is no contribution to the physiologically active effect, it is desirable to remove or reduce at least these two components. Of the ash, manganese oxide Mn ₂ O ₃ does not necessarily need to be removed because it can be expected to have a good effect on liver allerginase activity. In this way, in the present invention, a product obtained by removing or reducing at least potassium and sodium compounds from various component mixtures extracted from birch salmon is a birch salmon extract as a high-purity active ingredient. As for what to take, as long as there is no particular hindrance, it is not necessary to remove ash.

Next, an example of a general process for producing the liquid preparation of the present invention (related to high-purity drinks and foods) will be outlined.
(A) Hot water extraction: An extract is prepared by adding water (more than 6 times the dry solid weight) to dried birch bamboo. For this reason, the water to which the fine birch is added is boiled at a temperature of about 90 ° C. for about 1 hour. If the active ingredient is not sufficiently extracted at one time, after squeezing the first solution obtained by boiling first with a cloth bag, etc., preferably after adding birch extract, water is added to the residue for about 1 hour at 90 to 100 ° C. Boil in. Squeeze again and mix the first and second extract.
(B) Complex precipitation: A colored complex in which an acid (preferably a 2% hydrochloric acid solution) is added to the extract obtained in the step (a) so as to have a pH of 30 to 2.5 and mixed in the extract. To precipitate. This precipitated colored complex contains an active ingredient having a physiological activity. Collect the precipitate. Precipitates are obtained about 50% of the total dry weight of the hot water extract and 25% of the dried natural birch dry matter (relative to the amount of dry matter collected in this step).
(C) Ash removal: The acid added in (b) above and the high contents of K ₂ O and Na ₂ O are removed or reduced. Potassium and sodium compounds may be removed using molecular sieving techniques (eg, gel filtration) or other low molecular weight removal techniques. In the case of hydrochloric acid, the acid may be used as it is, and in this step, the solution can be made into a drug such as an ampule-filled injection. In this case, a process capable of setting the solid content in the solution to 2%, for example, is established, and the solution is packed in a small container such as an ampule and sterilized and stored.
(D) Drying: The solution obtained in (c) (containing the active ingredient) can be heated and dried at a heating temperature of 100 ° C. or less. When dried at 100 ° C. or higher, the properties of the polyphenol complex are changed, and the solubility is remarkably deteriorated. It is good to dry by freeze drying etc. which does not become high temperature.
(E) Solution preparation: The dried product (powder) obtained in the step (d) is mixed and dissolved in distilled water or physiological saline as required to dissolve the solution of the present invention (injection) Liquid). Moreover, it can also be mixed with the raw material of various drinks (beverages) and foodstuffs with powder. If solid content is known, it can also be set as a liquid agent in the solution state of the stage of (c).
(F) Storage: The prepared liquid is put in a container such as an ampoule (in the case of an injection) or a plastic bag (in the case of an infusion) and stored in a sterile manner. The ampoule amount is preferably an amount that can be used once, and refrigeration is desirable for storage. Alternatively, the dried product can be stored in a powder form at the stage of the drying step (d) or enclosed in microcapsules and dissolved and used as necessary. What is necessary is just to pack containers, such as a bottle and a pack, according to a conventional method with respect to a drink agent or foodstuffs. Of the above steps, C is omitted as long as it is not particularly a high-purity active ingredient.

In the above general process, before entering the complex precipitation (b) process, the hot water extract of the process (a) is preferably centrifuged (for example, in a centrifuge at 3,000 rpm for 10 minutes) and then filtered. , The passage of liquid through the filter is improved and the degree of purification is increased. Further, in the steps of hot water extraction (a) to ash removal (c), a specific molecular weight can be taken out and used by gel filtration. For example, a molecular weight of 450,000 or less can be taken out from the extract as a birch bamboo having the physiological activity expected by the present invention, and this can be put into the above steps (d) and below. Alternatively, a molecular weight of 30,000 or more can be taken out and put into the following steps (d) to emphasize, for example, antimutagenicity. When a molecular weight of 8000 or less is taken out and put in the following step (d), a drug or cream that effectively emphasizes atopic dermatitis can be obtained. Similarly, only polysaccharides or lipopolysaccharides can be specifically extracted from the hot water extract, and (d) the following steps can be performed in order to produce a drug that emphasizes immune enhancement and anticancer.

The steps of hot water extraction, complex precipitation, ash removal, liquid agent (product), storage, or complex precipitation, ash removal, drying, liquid agent (product) preparation, and storage of (a) to (f) described above are as follows. It should be reasonably assembled depending on the work scale and materials used, and is not limited to this, and further steps can be performed as appropriate. In addition to water, for example, alcohol, alcohol + water, or the like can be used as an extraction medium to extract the active ingredient of birch moth. However, since birch moths contain LPS (lipopolysaccharide) that induces macrophage activity, water (hot water) extraction that is likely to produce LPS is desirable. Of course, depending on the concentration, processing such as reducing LPS may be added.

Comparative test showing the effect of ash removal The effect of the treated extract (high purity extract) obtained by removing potassium and sodium according to the present invention and the birch extract (untreated extract) that does not go through the removal step Tests were conducted to compare the differences. That is, when an experiment was conducted by injecting the treated extract and the untreated extract of the present invention into small animals (6 mice each), those injected with the untreated extract into veins caused motor nerve malfunction. In contrast to this, all of the intravenous injections of the treated extract remained healthy without any abnormalities. From this, it is recognized that it is appropriate to remove or at least reduce K ₂ O and Na ₂ O, which are abundantly contained in the birch extract, as a liquid directly injected into living blood (or muscle). . On the other hand, when another 6 mice were fed with the untreated extract mixed with food, all the animals were healthy and excessive hypertrophy was suppressed without impairing their health. For oral administration or dosing, the birch extract of the present invention does not require ash removal.

Thus, the K ₂ O · Na ₂ O treated (reduced) extractant according to the present invention is not only a life-active substance that can be safely put directly into blood and muscle, but also when taken orally. As a less irritating substance, it becomes an effective substance for gastritis, duodenal ulcer, sputum, atopy, etc. In particular, for medications aimed at recovery after digestive surgery, medications with reduced K ₂ O · Na ₂ O work well, such as reducing irritation, stopping bleeding, and enhancing immunity. Moreover, the processed extract by this invention can also be mixed with an ointment, for example, and can be used as a coating agent with little irritation. In any case, the removal of the potassium / sodium compound has the effect of expanding the use of the birch extract, which is different from the conventional one.

Next, specific examples of the production process of the high purity active ingredient of the present invention reviewed above will be described. Each process (a)-(f) respond | corresponds to the same process of the said review. In addition, in the step (a), in addition to natural birch bamboo, experiments were carried out on birch bamboo cultivated in a solid medium of sawdust (especially birch) and birch cultivated in liquid medium.
(A) 200 g of natural birch bamboo was boiled in 1,200 ml of water. A total of 60.1 g of a blackish-brown dry matter was obtained from this solution. The dried product had a bitter woody odor. On the other hand, a total of 30 g of dried product was obtained from 2.3 kg of the dried sawdust solid culture. This was a savory taste with a bitter taste. In addition, the hot water extract of mycelium was dried from 300 cc of the liquid culture solution to a weight of 2.3 g and the dry weight of the same solution was 1.03 g, and 1.53 g was obtained from these liquid cultures.
(B) A hot water extract of natural birch was taken with acid treatment, and a precipitate was collected. 30 g was obtained from 60.1 g of the dried extract of natural birch.
(C) The acid and impurities K ₂ O and Na ₂ O were removed from the 30 g precipitate by gel filtration.
(D) The active ingredient-containing solution obtained by filtering the acid and impurities was dried by freeze drying to obtain 13.5 g of dried powder of natural birch. Further, 2.9 g of a purified product having a molecular weight of 450,000 or less by gel filtration (S300) was obtained by dry weight. In these various fractions, physiological activities such as antiviral activity, such as anti-AIDS virus activity and anti-influenza virus activity are widely observed, as will be described later.
(E) The active ingredient liquid can be used as it is, but in order to make a dried product into a solution, a solution containing 0.01 to 99% (by weight) of dry powder, practically 0.05 to 50% The solution is dissolved in distilled water or physiological saline so as to be a 0.1 to 5% solution, more preferably a 0.7 to 3% solution.
(F) Place the solution in a capsule for injection and sterilize and store. When using for infusion, place in a plastic bag or other container and sterilize and seal.

The birch salmon extract of the present invention can be made into a high-purity birch salmon-containing liquid that is administered parenterally directly into the blood or muscle in the form of injection or infusion as described above. As a product, it can be used in various forms such as tablets, granules, capsules, drinks (beverages) and the like, and as a food containing a cabbage anatake active ingredient. As a drink (beverage), the birch extract of the present invention can be widely and generally contained in an amount of about 0.01 to 50% by weight, but in practice a solution containing 0.1 to 5%. Is preferable. Extracts prior to ash removal treatment and oral preparations including drinks include additive compounds to enhance taste, shape and physiological activity, such as acidulants, sweeteners, lactose, oligon sugar, trephalose , Dextrin, corn starch, potato starch, medicinal herbs, various vitamin preparations, alcohol, birch sap extract, propolis, royal jelly, coriander (periaceae), and other physiologically active substances.

Whether it is a drink (liquid) or a tablet (solid), the birch extract obtained according to the present invention generally has a daily intake of 0. Taking 5 to 3 g as a standard, it may be taken in a form such as taking three times a day. This range of intake is certainly within safety standards. Mammals other than humans can also be used at the same weight ratio.

As described above, it is recognized that the birch extract of the present invention has excellent physiological activity and action regardless of whether it is a high-purity active ingredient from which ash has been removed or a non-high-purity ingredient. That is, the present invention contains a mixture of various components extracted from birch salmon as an active ingredient with ash removed or reduced, or removed or as it is, and has the following many physiological activities against various symptoms. Alternatively, it can be used as a drug having an action: antiviral activity, specifically antiretroviral activity (activity to suppress rotrovirus such as AIDS virus HIV, human T cell leukocyte virus HTLV-1), And anti-influenza virus activity (activity that suppresses influenza virus), etc., and antimutagenic (activity that suppresses harmful effects of mutagens such as benzopyrene), antitumor activity (activity that suppresses cancer and other malignant tumors), Activity by LPS (Lipopolysaccharide occupying a specific molecular weight in birch extract) Increased immunity by males (explained later), macrophage activity (the action of birch oyster mushroom extract activates macrophages), central nervous activity (an action that activates the central nerve that cancer patients, or those with weakness) Catalase activity (activates and activates oxygen catalase deficiency), protease activity (activates and activates protein digesting oxygen protease), SOD-like activity (acts similar to oxygen SOD that neutralizes the toxicity of active oxygen) Described later), prostate treatment activity, hyperproliferation reduction activity, appetite enhancement activity, urinary excretion promotion activity, hair growth activity (especially for use as a hair growth agent or permanent solution described later), various antibacterial activities (for example, anti-tumor activity) MRSA activity, anti-O-157 activity, etc.), hemostasis activity, toothache suppression activity, immune enhancement activity, spatula cell proliferation inhibitory activity (increase in various cancer cells) ), Scientific reduction activity, oxygen absorption activity, coloring action (dyeing of eyebrows, white hair, etc. with black pigments contained in birch anatake, coloring of cloths and ceramics, coloring glaze composition, food Colorants, etc.), far-infrared radiation and other radiation radiation action, vitamin production action (Bamboo anatake contains provitamin D ₂ = ergostere and synthesizes vitamin D by sunlight), abdominal pain, gas belly and constipation recovery Activity, plant spoilage prevention activity, growth inhibition effect of aerobic bacteria, gastric ulcer, prostate hypertrophy / duodenum inhibition activity, A type, B type, hepatitis C inhibition activity, liver allergenase activity, sputum recovery effect, marrow leukocytosis bone marrow Selective destructive action on cells, reduction of malnutrition by orally collected carbon tetrachloride, recovery of libido, recovery from fatigue, digestive system diseases (heartburn) (Gep, nausea, diarrhea, etc.) Restoration action, Calcium enhancement action in osteoporosis (Calcium enhancement by the formation of vitamin D in birch extract), Protease inhibitory activity (activate protease by molecular weight of birch extract), bokeh restoration action, obesity Preventive action, atopic dermatitis treatment action, various diseases of collagen disease (progressive systemic sclerosis, rheumatoid arthritis, rheumatic fever, nodular polyarteritis, dermatomyositis, etc.) treatment action, and other general health promotion actions. The drugs of the present invention described above can be used in combination with or in combination with various other existing drugs such as AZT, DDI, ordinary anticancer drugs, and many other Chinese medicines. For example, when mixed, it is generally possible to contain a birch extract active ingredient in a proportion of 0.01 to 20%, preferably 0.1 to 5% of the total weight of the drug.

Among the above-mentioned antiviral activities, AIDS virus has already been mentioned, so here, a test example is shown for anti-influenza activity. The first test was for influenza B (B / Bankok / 163/90), and the test solution was obtained using the birch extract of the present invention (before ash removal). Target virus: Influenza B type (virus amount 100 TCID)
Test solution: 20 mg birch extract was dissolved in 10 ml distilled water (0.2% solution)
Cell: MDCK (test tube culture)
Observation period: 5 days 37 ° C. Visual interest and the amount of virus are 0.2 ml respectively, the amount of culture solution (maintenance solution) is 1.0 ml [effective concentration is 0.2 / (0.2 + 0.2 + 1.0) = 0.142857 ml / ml. 285.7 μg / ml by weight / volume ratio]. This is put into the first well of 12 wells and serially diluted 2-fold, and CPE (cytopathy) is observed daily. Since it was observed to suppress CPE up to 3 wells (4-fold dilution), the minimum effective concentration (MIC) is 71.4 μg / ml by weight to volume ratio. In this way, it was confirmed that the present extract of birch salmon extract effectively suppresses influenza virus. The birch extract of the present invention was found to be effective against North Sea B-type and Hong Kong type A influenza viruses (8-fold dilution) by the same procedure as above. The results are shown in Table 4 below.

Next, the SOD-like activity described in the above-mentioned various drug activities will be described. SOD refers to superoxide disproportionated oxygen (superoxide / dimmutase), which has recently been in the body of mammals and acts to protect organisms from the toxicity of active oxygen. The birch extract also has a similar action, which is called SOD-like activity. This activity can be measured using special equipment.
Measuring apparatus: JES-RE-1X type ESR (electron spin resonance) manufactured by JEOL Ltd.
Apparatus sample: Purified water (Japanese Pharmacopoeia purified water) dissolved in the following ice making water at a concentration of 50 mg / 50 ml
Result: The SOD-like activity (unit: Units / ml) was 10.96, and it was recognized that there was a remarkable SOD-like activity. When tap water (Musashino City, Tokyo) was used, high SOD-like activity was still observed. Similar activity was also observed in snow water (clean, clustered water with low temperature melting of fresh snow from Nayoro City, Hokkaido). When these samples were covered with tournament-containing prickly stones (which generate negative ions), which were separately developed by the present inventor, it was found that the SOD-like activity was higher in the samples that were covered about 50 times. This proves that snow water is effective as a liquid for dissolving the extract of birch moth. At the same time, the effect of imparting weak energy, which will be described later, has been proved.

The activity by LPS described in the drug will be described. It can be overlooked that the effect of LPS (lipopolysaccharide) contained in the birch moth is largely due to the LPS (lipopolysaccharide) contained therein. One of the biological activities that protect the human body from bacteria and viruses is an immune enhancing action. Cells involved in immunity include lymphocytes and macrophages, and LPS (lipopolysaccharide) contributes to the activation of macrophages. The birch extract of the present invention contains a large amount of such lipopolysaccharide, and a test for confirming this was conducted. The results are shown in Table 5. In addition to the birch extract, carrot extract (component extracted from carrot root) and carrot leaf extract (component extracted from carrot leaf) were used as specimens in this test. The specimens were prepared by accurately weighing 500 mg each of the birch extract, carrot extract, and carrot leaf extract, and adding distilled water for injection to each to a final concentration of 100 mg / ml. This was wet-extracted in a water bath at 56 ° C. for 3 hours, and then centrifuged, and the supernatant was taken as a stock solution for a sample for measurement. The LPS amount was calculated by converting the amount of LPS using a Limulus test kit (Endspace, Seikagaku Corporation) using a chromogenic substrate capable of specifically measuring only LPS as the amount of Escherichia coli LPS attached to the kit. Value (μg / ml).

Table 5

Specimen name LPS content Birch tree extract 1610 Carrot extract 0.85 Carrot leaf extract 29.5 As is clear from the above table, the birch tree extract of the present invention contains an overwhelmingly large amount of LPS. Since it activates macrophages well when collected in the body, it has a strong immune enhancing effect. As a result, the organism's resistance to various bacterial or viral diseases can be increased, so that the birch extract of the present invention can be used as an LPS activator, as a drug, and as a health food or beverage ) Can also be used.

Next, the birch extract of the present invention is not limited to drugs, and can be used for products (drinks and foods) that should be called “healthy foods and drinks” for maintaining or enhancing health widely. . In general, in the case of these healthy foods and beverages, birch extract can occupy a range of 0.01 to 50% of the product weight, but the specific ratio is within the above range depending on the maintenance of the quality of healthy foods and the preference of consumers. Can be changed in various ways. The birch salmon extract used for health food and drink products uses the birch salmon active ingredient limited to a high purity product and provided with energy. Of the aspects of healthy eating and drinking products, first, examples of beverages (drinks) will be described. Examples are from Example 1 to Example 17.
Example 1 Concentrated orange juice-flavored birch salmon beverage Example 1 Concentrated orange juice (60 ° Brix) beverage Orange juice base * 2,000 ml birch salmon extract powder 83 g Sugar 1,0221 g Water 6,096 ml Concentrated juice (60 ° Brix) 16.65 liters * Orange juice base has the following formulation.
Concentrated fruit tree (65 ° Brix, citric acid weight%) 1,000 ml 50% citric acid solution 245 ml emulsified flavor 50 ml water 538 ml 2,000 ml Orange juice base is blended with the other ingredients of Blending Example 1 according to the production method described below As a result, 16.65 liters of fruit juice 40% (volume) concentrated juice was produced. The resulting thick juice was an orange-flavored birch juice, and had a delicious taste that did not cause any sense of incongruity due to the inclusion of birch powder. Depending on your preference, the amount of birch extract may be halved. In this example, the birch extract was used as a powder, but a birch broth liquid culture may be used. In this case, the water content and solid content contained in the liquid culture are calculated so as to have the same composition as above. In addition, if necessary, the amount of bamboo shoots can be increased or decreased within the safety standard.

Example 2 Formulation of 15% orange juice type birch salmon drink Example 2 Orange juice type beverage beverage base * 1,000 liters of birch salmon extract powder 10kg Sugar 3,273kg Water 26,050 liters finished Orange juice 30,000 liters * Beverage base composition ratio Concentrated Satsuma mandarin juice (65 ° Brix, 5.9% citric acid, 12 ° Brix for original juice) 1,000 ml 50% citric acid solution (specific gravity 1.246, 15 ° C.) 156 ml 10% orange emulsified flavor 146 ml water 204 ml 1,500 ml When 1,000 liters of beverage base was prepared at the blending ratio and blended as in Blending Example 2, about 30,000 liters of ordinary 15% (capacity) orange juice flavored birch was obtained. Depending on taste, the birch powder may be halved.

Example 3 Blended coffee milk type birch salmon beverage Example 3 Coffee milk type beverage birch salmon extract 0.5 kg Milk 40 kg Nonfat milk 20 kg (liquid) Sugar 7 kg Coffee extract 30 kg (10-15 kg when powdered extract) Caramel 0.3 kg coffee Fragrance 0.1 kg Water 2.0 kg (20-15 kg when coffee is powdered) 100 kg This is a health drink containing 0.5% birch extract by weight in coffee milk, and even with the inclusion of birch No harm to the original flavor of milk. Birch powder may be halved according to preference.

Example 4 Carbonated beverage type birch salmon beverage blending example 4 Carbonated beverage type birch salmon extract 0.5 kg Orange juice 2 kg Sugar 11 kg (Add appropriate amount of citric acid according to taste) Water 86.5 kg Carbon dioxide gas appropriate amount 100 kg

Example 5 Yogurt type birch salmon drink formulation example 5 Yogurt type fermented skim milk 40 kg (may be fermented raw milk) Sucrose 14 kg stabilizer * 0.35 kg (* Monoglyceride is preferred) Fragrance 0.05 kg Water 45.1 kg Birch salmon extract 0. 5kg100kg

Example 6 Formulation of lactate type birch salmon drink Example 6 lactate type lactate 10 kg birch salmon extract 0.5 kg sugar 0.5-3 kg stabilizer * 0.05 kg (* monoglyceride is preferred) water suitable amount finished 15 kg sugar amount, accordingly The sweetness varies slightly depending on the amount of water, but the birch extract contains about 3%. This does not impair the original taste. If desired, the birch extract may be halved.

EXAMPLE 7 Lactobacillus Beverage Type Birch Salmon Beverage Formulation Example 7 Lactic Acid Bacteria Type Citrus 6x Concentrated Juice 1.5 L Citric Acid 650 g Orange Fragrance 150 ml Birch Salmon Extract 0.5 kg Dye 10 g Stabilizer * 200 g (* Monoglyceride is preferred) Sugar 24 kg 100 kg

Example 8 Milk / fruit juice type birch salmon drink combination example 8 Milk / fruit juice type (all ingredients are all kg) Birch salmon extract 0.5 milk 20 skim milk 40 sugar 11 apple juice 20 citric acid 0.2 CMC (stabilizer) 0.3 dye 0.001 water 5.51 100 kg

Example 9 Juice type lactic acid beverage containing birch salmon bamboo 9 Juice type lactic acid beverage (all ingredients are kg) Birch salmon extract 0.5 Fermented skim milk 5 Sugar 14 Apple juice 10 Stabilizer 0.20 Citric acid 0.25 Ascorbic acid 0 .05 Fragrance 0.10 Water 70.5 100kg

Example 10 Sap type birch salmon drink formulation example 10 Sap drink (all ingredients are in kg)
White birch sap extract 40
Sugar 10 (oligosaccharide)
Birch extract bamboo 0.25
――――――――――――――――――
50.25kg
Occasionally about 0.3% citric acid or ascorbic acid may be added. Since white birch extract contains an antioxidant sweetener (xylitol), its cooperation with birch extract is extremely healthy A fresh drink.

Example 3 Milk coffee type birch salmon drink Formulation Example 11 Milk coffee type birch salmon extract 0.5 kg
Milk 90 liters sugar 13.35 kg
Glucose 3.75kg
2 kg of powdered coffee
Stabilizer 300ml
Caramel appropriate amount Coffee Essence 200ml
71 kg of water
――――――――――――――――――――――――――――――
The final volume of 180 liters of birch extract is about 0.2-0.3% by weight. Depending on your preference, the amount of bamboo shoots may be halved.

Example 12 Melon Beverage Type Birch Salmon Beverage Formulation Example 12 Melon Milk Beverage Birch Salmon Extract 0.9 kg
Non-fat fruit cultivation ridge milk 7kg
3.75 kg of sugar
Glucose 4.3kg
Astelbalm 3.4g Citric acid 450g
Emulsification stabilizer 1.2kg
Melon Essence 100ml
Melon dye 2g
153.9 kg of water
………………………………………………………………………………………………………………………………………………
The content of the finished volume of 180-liter birch extract is about 0.4-0.5% by weight. Depending on your preference, the amount of birch may be reduced.

Example 13 Sport drink type birch salmon drink Mixing ratio of mixed powder Birch salmon extract powder 10g
Purified salt 0.5g
VC 0.03g
VB hydrochloride 0.03g
Sodium citrate 1.7g
Magnesium chloride 0.2g
Calcium lactate 0.2g
2.4 g of powdered citric acid
Natural powder flavor 2.0g
Anhydrous glucose 80g
Fructose 12.94g
――――――――――――――――――――――――
110 kg
The mixed powder of the above composition is dissolved in 200 to 250 ml of water to obtain a sports drink. This was bottled and sterilized to obtain a sports drink with Brix 6 °, acid 0.15% and pH 3.8. The content of the birch extract is 5 to 4% by weight. Depending on your preference, the amount of birch may be halved.

Example 14 Mixing Example of Cola-type Birch Salmon Beverage Stock Solution 9g Branberry Salmon Extract Powder 200g Granulated Sugar 200g Cola Base 6g Citric Acid 1g Water 144ml 360ml ... This stock solution and 1,440ml carbonated water are blended to make 1,800ml cola beverage It was.
The Brix was 11 °, the acidity was 0.08%, and the gas amount was 3.5. After filling this cola drink into a container, it is sterilized at about 60 ° C. for 30 minutes. The birch extract contains about 0.4-0.5% by weight. The amount of birch may be halved according to preference.

Example 15 Cider type birch salmon drink Stock solution blending example Birch salmon extract powder 50g
Granulated sugar 1,020 g
8.3g of citric acid
Sodium citrate 0.5g
Cider Essence 12.5ml
908 ml of water
―――――――――――――――――――――――――――
2,000ml
10,000 ml of cider was made by adding 8,000 ml of carbonated water to this 2,000 ml cider stock solution. Brix 10 °, acid 0.08%, gas capacity 3-4. After filling the container, sterilize at about 60 ° C. for 30 minutes. Depending on the preference, the amount of birch may be halved.

Example 16 Apple soda-type birch salmon drink Stock solution blending example Birch salmon extract powder 10g
Apple 1/5 concentrated clear juice 20g
240g granulated sugar
Malic acid 1.3g
Citric acid 1.5g
Sodium citrate 1.5g
Caramel 10% solution 6ml
Apple aroma 2ml
719 ml of water
―――――――――――――――――――――――――――
1,000ml
By adding 1,000 ml of carbonated water to the 1,000 ml stock solution, an apple soda type beverage having Brix 12 °, acidity of 0.3%, and gas amount of 2.0 to 2.2 was obtained. After filling the container, sterilize at about 80 ° C. for 20-30 minutes. Depending on the preference, the amount of birch may be halved.

Example 17 Grape soda type birch salmon drink Stock solution blending example Birch salmon extract powder 10g
Grape 1/5 concentrated fruit juice 20g
240g granulated sugar
Sodium citrate 0.2g
Grape essence 2ml
Pigment proper amount Powdered citric acid 2.4g
725 ml of water
――――――――――――――――――――――――――
1,000ml
1,000 ml of carbonated water was added to 1,000 ml of grape soda stock solution to make 2,000 ml of birch salmon drink. After filling the container, sterilize at 80 ° C. for 20-30 minutes. Depending on the preference, the amount of birch may be halved.

About the production of birch salmon drink (general explanation)
(A) To make the orange juice base shown in the previous formulation row 1 or 2, the raw materials are put into a mixing tank with a stirrer and mixed well. This blending tank is sealed and agitated and mixed in a vacuum state. If it is an open type, there is a risk that air will get in and the flavor of the juice will be impaired. If an open tank is used, vacuum treatment is performed after stirring. The prepared juice base may be attached to a container, refrigerated to 0 ° C. to −4 ° C. and aged for several days. At this time, weak energy (for example, irradiation of far infrared rays or negative ions) described later may be applied. Pay attention to bacterial control during storage. Use antibacterial natural products and preservatives as necessary.
(B) To prepare a processing syrup of bottled orange juice, add water to the tank, add sugar according to the prescription, and dissolve with stirring. If necessary, after filtering with a squeezing machine or asbestos filter, a beverage base may be added and stirred.
(C) Heat sterilization treatment Using an instant sterilizer, heat to 93-96 ° C and hold for 5-10 seconds as it is or immediately after cooling to 77-82 ° C and send to a filling machine to wash and heat bottles Fill, cap, and sticker to make the product.

General notes on birch drinks : a. If the protein such as dairy products does not contain a large amount, it is preferable to suppress the final pH to 4.3 or less, because it suppresses the propagation of bacteria such as Bacillus subtilis (for example, Bacillus butyls). Preferably, pasteurization is performed at 75 ° C. for 20 minutes. Conversely, if the protein is contained, it will coagulate unless the pH is 5.7.
b. Since the birch extract has the property of precipitating at pH 3.0 or lower, it is desirable to maintain the pH at 3.0 or higher.
c. As the carbohydrate, maltose, glucose, oligosaccharide, honey, trephalose and the like can be used depending on the purpose, but oligosaccharide is preferable for the growth of enteric bacteria. Moreover, aspartame, stepia and the like can be used as a special sugarless type (low calorie and sweet), but in many cases, it is good to mix with glucose or the like for taste.
d. In order to make a carbonated drink of birch salmon, carbon dioxide gas is injected into a cooling stock solution of 4 ° C. or less with as much H 2 O as possible and less fruit juice. The more substances other than high temperature and water, the more carbon dioxide gas is generally bubbled out to the outside air and the purpose is not achieved. Therefore, it is preferable to make orange fruit juice about 3% or less, add 0.5% birch bamboo and adjust pH and sugar content to make a carbonated beverage. It is desirable to suppress heating to 120 ° C. or lower.
e. In addition to the drinks exemplified above, snow water (described later), mineral water, or deep sea water is used as the beverage base, and birch salmon extract, and other additives such as sweeteners and flavors as necessary. Things can be added to make a drink. In addition, green tea, black tea, barley tea, oolong tea, saffron tea, herbal tea, jasmine tea, medicinal herb tea, and other teas, with addition of birch extract and other additives similar to those mentioned above as necessary It can be a beverage. Furthermore, it can also be set as the drink which added coriander (savory fragrant vegetables) to the birch extract.

The birch extract according to the present invention is a health drink product other than the beverages described above, such as food mixed with confectionery such as candy, beverage mixed with soft drink, coffee, cocoa, liquor, seasoning (liquid・ Food mixed with ice, ice confectionery (ice cream, sorbet), hamburger, food fiber (eg konjac), starch, protein and other liquids containing birch extract it can. In addition, as products other than food and drink, for example, suppositories shaped by mixing in oils and fats such as cocoa butter, suppository injections, hygiene products in which birch salmon extract is impregnated in bandages and napkins, gargles, It can be used as a vaginal cleanser (see “Body Insertion Agent” below), ointment, petrolatum poultice, etc., or mixed with birch salmon extract in cream, shampoo, rinse, hair growth medicine, perm solution, etc. Product. In particular, the hair growth agent and the perm solution will be described. An aqueous solution of birch extract (concentration is, for example, 0.01 to 99%, preferably 0.1 to 50%) can be used as it is. In order to increase this, it is recommended to use the extract aqueous solution after electrolysis. Instead of electrolysis of the aqueous solution, the birch extract may be added to the electrolyzed water to form an aqueous solution. The aqueous solution is separated into an alkaline side (pH 11 to 12) and an acidic side (pH 2 to 2.5) by electrolysis, but they are used separately (for example, the alkali side first and then the acidic side). Or may be used in combination. As water, tap water and ground water can be distilled and snow water can be used. The combination of birch extract and electrolysis gives weak electric energy to the aqueous solution, so that penetration into the skin and hair is promoted, and the effects of hair growth and hair growth can be further enhanced. In addition, birch salmon contains a large amount of black pigment, and thus has a dyeing effect on hair.

In relation to solid preparations such as suppositories, the birch extract of the present invention, particularly a high-purity extract from which ash has been removed, can be made into a solid preparation called an “in-body insertion agent” for preventing AIDS. It was developed specifically to avoid and prevent AIDS infection caused by women's assault. As an example of production, cocoa butter is used as an excipient, and birch oyster mushroom extract (preferably from which ash has been removed) is mixed in a certain ratio (for example, 30: 1 by weight). First, cocoa butter is melted at 40 ° C. or less with a water bath, and the birch extract is mixed and stirred, and the temperature is lowered to 23 ° C. to crystallize cocoa butter. Thereafter, the crystals are melted at 32 ° C., poured into a mold (for example, a mold for producing a bullet-shaped product), cooled and solidified. The solidified product is wrapped and stored in a heat-insulating packaging material so that it does not melt and collapse due to heat. One solid bullet product has a size in the range of about 2 to 6 g, preferably about 3 g in practice, and contains 0.1 g of birch salmon extract active ingredient. (For simplicity, coconut butter may be used, and 0.1 g of the active ingredient is contained in a solution dissolved at 23 ° C. or higher and solidified when placed at a low temperature of 23 ° C. or lower. A capsule-like product can also be injected.) A test was conducted to confirm the anti-AIDS activity in practical use of this solidified product. Insert the solidified product into the woman's body (vagina), wipe the fluid melted at body temperature with a 6 x 4 cm gauze after a certain time, wet this gauze with 10 cc of water, squeeze the gauze and impregnate it Collect the component liquid. The collected liquid was diluted with distilled water, and AIDS virus was added to the diluted liquid using MT-4 cells, and the degree of inhibition of AIDS virus growth (100% inhibition) was confirmed in the well of a 96-well plate. The results are shown in Table 6.

Table 6

* Time * Effective amount ** 20 (hour) 1,000 μl / ml 35 100070 1,000 * Time is the time elapsed after insertion into the body ** Minimum effective concentration (1 well) controlling 100% of AIDS virus growth As is apparent from FIG. 1, after 70 hours had passed after insertion, the active ingredient of birch moss gave 100% inhibition of AIDS virus growth. In addition, even though it was inserted for a long time, it was an active ingredient with no irritation from which ash was removed, so no problems such as sagging or inflammation occurred in the mucous membrane. Thus, this in-vivo insertion agent is effective for about 3 days after wearing, and is effective in avoiding and preventing unintentional AIDS infection. In addition, since the excipient is cocoa butter, this intracorporeal agent can also be put in the mouth, which helps to prevent oral infection of AIDS. The in-vivo insert of the present invention can be carried out in the form of injecting an active ingredient into a capsule made of a low-melting-type material that melts at body temperature, for example, instead of the above-described bullet-like cast-molded product.

As described above, the birch extract can be mixed into various soups, soups, foods, and the like, in addition to beverages having a specific composition. Some practical examples are given.
(1-24)
1. Concentrated noodle soup: 100 g of birch salmon extract (50 g depending on taste) was mixed with 10 liters of concentrated noodle soy sauce, sugar, syrup, chemical seasoning, bonito and so on.
2. Mantsuyu (tsuke soup): 280 g of birch extract (may be 140 g if desired) was added to about 29 kg of mantsuyu consisting of soy sauce, sugar, synthetic seasoning, water and the like.
3. Soba soup: Soy sauce, sugar, and other various additive components were added to 10 liters of birch salmon extract in soba soup that was finished in a total amount of 1.0 liter. (5g may be used if desired)
4). Instant udon soup: 0.1 g birch salmon extract was mixed with 10.6 g instant udon soup made with salt, beef broth, bonito flavor, powdered sugar, soy sauce, etc. to give a birch salmon soup. The birch extract may be halved by preference.
5). Ramen soup: A ramen soup based on shrimp meat, pork powder, or a raw Chinese soup made of soy sauce and other additive ingredients was prepared by adding 10 g (or 5 g, if desired) of birch salmon extract per liter.
6). Perfect ramen soup: powdered soy sauce, salt, sugar, other ingredients, etc., and 350g birch extract, 3.5g (can be halved if desired)
7). Yakisoba sauce: salt, sugar, powdered soy sauce, glucose, beef powder seasoning, tomato powder, onion powder, pepper, etc. Yakisoba sauce was mixed with 1 g of birch salmon extract (halved by preference).
8). Genghis Khan Sauce: 10 g of birch salmon extract was added to 1 liter of sauce made of soy sauce, onion, flame taste liquid, ginger, apple, sugar, etc. to make a Genghis Khan sauce. When the weight is on a weight basis, 20 g (half halved depending on preference) of birch salmon extract may be added to about 2,000 g.
9. Yakiniku sauce: 100 g (half halved depending on taste) of birch salmon extract was added to 10 liter sauce consisting of soy sauce, flame taste liquid, salt, sorbit K, MSG, tomato puree, onion and the like to make a grilled meat sauce.
10. Worcester sauce: 10 liters of birch extract was added to a 1,000 liter sauce consisting of tomato extract, carrot extract, sugar, liquid sugar, salt, brewed vinegar and the like to make a Worcester sauce. In the case of tonkatsu sauce, 10 g of birch extract is added per liter.
11. Spaghetti sauce: 1 g of birch extract was added to 120 g of retort pack sauce consisting of carrots, minced meat, ketchup, tomato puree, apple boil, and so on.
12 Tomato ketchup: Tomato ketchup was prepared by adding 1.0 kg of birch extract (half halved according to preference) to 108 g of ketchup consisting of tomato puree, clove, meat katsura, mace, pepper, sugar and the like.
13. Mayonnaise: 100 kg of salad oil, vinegar, egg yolk, salt, fragrance, MSG Amiflex A-1, etc. was added with 1 kg of birch extract to make mayonnaise.
French dressing: French dressing was made by adding 1% (by weight) birch extract to a dressing made of salad oil, western vinegar, salt, onion juice, lemon juice and the like. A salad dressing was made by adding 0.5% to a salad dressing consisting of salad oil, egg yolk, vinegar, corn starch, salt, water and the like. The birch extract may be halved by preference.
15. Various soy sauces: Low salt-enriched acid radish pickled solution (composed of flame mouth soy sauce, flame mouth amino acid, salt, MSG, succinic acid, citric acid, malic acid, 50% lactic acid, glacial acetic acid, sorbit, etc.) To 100 liters, 1.0 liter of birch extract (halved by preference) was added. In addition, in the case of soy sauce-based liquids used for vegetable soy sauce, Yamabuki pickles, etc., about 100 g of birch extract can be added to 10 kg of liquid weight.
16. Chosen pickle solution: Shin flame taste liquid, MSG, sorbit, dried garlic, 50% lactic acid, pepper, grated ginger, 10 g of birch salmon extract (halved by preference) in about 960 g of the Korean pickle solution composed of salt and the like.
17. Dumpling: About 1% (by weight) of birch salmon extract was added to a dumpling raw material consisting of cabbage, minced pork, green onion, soy protein meat, thick soy sauce, sesame oil, garlic, ginger soup and the like. If desired, 0.5% birch extract may be used.
18. Corned Beef: A corned beef was made by adding 100 g of birch extract to approximately 9.7 kg of a corned beef material prepared by adding spices to steamed beef, mutton, onion powder, garlic and the like. In the case of corned beef hash, add cabbage anatake extract of about 1% of the material weight. Depending on taste, birch may be halved.
19. Hamburger: Make hamburger with 0.1% -5% birch extract from about 100kg of ingredients consisting of ground meat (horse, beef, etc.), seasonings (salt, soy sauce, etc.), bread crumbs, onions, spices, etc. It was.
20. Fukujinzuke: Fukujinzuke was made by adding 50 g of birch extract to about 1 liter of Fukujinzuke liquid (soy sauce, light mouth taste liquid, sorbit, sugar, 50% lactic acid, pigment, etc.). It is recognized that 0.1-5% of the pickled liquor is a suitable amount.
21. Powdered soup: A powdered soup was prepared by adding about 10% of birch salmon extract to a bean soup material consisting of powdered beans (or tomatoes), hardened cottonseed oil, salt, MSG, smoked meat flavor and the like. In the case of powdered consomme soup, the birch extract can be added at a weight ratio of 0.1% to 10%.
22. Canned concentrated vegetable soup: carrot (chopped), onion (round slice), dried peas, flour, potatoes, noodles, salt / sugar and other seasonings 0.1% -10% birch extract Into a canned concentrated vegetable soup. The same applies to canned soups such as concentrated tomato cream soup, beef soup, Western cream soup, celery cream soup and onion soup.
23. In addition, bread, cookies, biscuits, campans, etc. Other starchy foods such as udon and buckwheat, protein foods, 1-10%, or in some cases 1-5% birch salmon extract of the present invention, health food It can be. The same applies to oily foods such as vitamin E. In addition, spices and herbs can be mixed and added to them.
24. Furthermore, it is recognized that an aqueous solution obtained by dissolving a birch extract in electrolyzed water (or the same solution obtained by electrolyzing an aqueous solution of birch extract) has high antibacterial activity (for example, anti-O-157 activity). Therefore, it can be used as an edible antibacterial liquid that is used by spraying or dripping on raw vegetables or other raw foods. This is also one form of the health food / drink product according to the present invention. Specifically, the electrolysis aqueous solution of the birch extract, as it is, or appropriately adding a seasoning or a fragrance, for example, sprayed on the raw vegetables (salad) or sprayed as a liquid, Pathogenic bacteria that may have adhered can be suppressed. This can also be called an antibacterial dressing. However, the application is not limited to vegetables, but extends to fresh cream of cake, fresh confectionery, seafood (sashimi and tataki), raw meat (beef and horse meat), and the like. Depending on the target to which the antibacterial liquid is applied, glucose, maltose, trephalose, etc. may be added as a thickening agent so that the liquid does not drip and be lost.

As described above, the present invention is intended to enhance the effectiveness by using a high-purity birch extract as described above. It is intended to increase the effectiveness of the extracted components by performing a treatment step of irradiating the active ingredients with weak energy such as negative ions or far-infrared rays (wavelength range of about 4 to 14 microns). The weak energy treatment step is performed by adding far-infrared rays and negative ions, as well as snow water (pure frame / high energy), which will be described later, to the extract. It is recognized that the application of weak energy enhances the internal energy of the birch moth bamboo active ingredient and further improves the physiological activity. Specifically, as a method for imparting weak energy, the present inventor separately applied (the “bioactive device” filed on July 17, 1997) “Blowing equipment or contactor material or environmental activity using tourmaline” This can be done with equipment or the like. Briefly, a fan material that uses tourmaline, such as a prickly pear with a tourmaline encapsulated with fine stones, is used to bathe birch extract (liquid or solid) tens to hundreds of times. Thus, the activity of the birch extract increases, that is, the internal energy is enhanced and the various activities are further increased. Negative ions are emitted from the face of the electric stone prickly pear, and far infrared rays are also emitted. In order to intensify far-infrared radiation, a far-infrared grill (for cooking) or a planar heater incorporating carbon fiber may be used in combination. The increase in internal energy can be confirmed by the so-called O-ring test or grip strength test, and humans who have taken active ingredients of birch moth that have been irradiated with weak energy are more likely to have finger strength or It was recognized that the grip strength increased. The active ingredient after irradiation is absorbed smoothly into the cell membrane of the living body, and the absorbability in the body is increased.

As a weak energy application method in place of the above weak energy irradiation, one method is “snow water” (which will be described later) that originally has weak energy or spring water that also has weak energy. A similar enhancement of physiological activity can be obtained by making a solution of the active ingredient using For example, for atopic dermatitis, a very good therapeutic effect was obtained against ordinary water by drinking the active ingredient of birch moss with “snow water”. Furthermore, as a second method, the same effect can be obtained by taking water (tap water or groundwater) artificially given with weak energy by ionization or far-infrared irradiation together with an active ingredient of birch salmon. This is because the action of negative ions and far infrared rays as weak energy contained in water is added to the birch extract. For this reason, as a third method, for oral doses, harmless rock minerals (such as Chinese talc, tourmaline = tourmaline) and plants (Chinese “Rafuma”) with these functions (weak energy). It is possible to obtain a result that may be added to and mixed with the birch salmon extract of the present invention, and these additives continue to give weak energy to the main active ingredient in the mixture and are weak in the body. When the energy-containing substance touches the sensitive mouth, the information is transmitted to the whole body and the physiological action is activated, thereby sending a signal from the stomach wall and the intestine to activate the original function of the cerebrum. When these additives enter the digestive system, they come into contact with moisture, give weak energy to water molecules, and subdivide the water molecule clusters. The fourth method is to use birch extract with electrolyzed water, which is made by dissolving birch extract into various electrolyzed water (see Table 7). When an anti-HIV test (100% inhibition) was performed using the results shown in Table 7, the results shown in Table 7 below were obtained.

Table 7

Bamboo anatake extract + electrolyzed water HIV inhibitory activity 100% inhibitory well type electrolyzed water type 3 days culture 6 days culture snow water super acidic water 13 well 12 well snow water strong alkaline water 13 "12" Groundwater super-acidic water 13 "12" Groundwater strong alkaline water 13 "12" Note: Cell damage was observed in 8 wells for all of the 3-day culture and the 6-day culture. The control was not treated with groundwater 13 "11" cells for 8 wells, and the initial concentration of the birch extract was 300 μl / ml (1 g / 10 cc). Each well contained an aqueous solution of birch salmon, AIDS virus, and healthy cells, and each well was observed on the 3rd and 6th days of culture to identify a well that 100% of AIDS infection was blocked. As seen in Table 7, the activity increased by 1 well in the 6-day culture. Water is divided into an acidic side and an alkaline side by electrolysis, but not only that, but it is considered that the weak electric energy is imparted to the water itself, which contributes to the activity enhancement.

In general, until now, medical doctors have focused only on the main active ingredients of therapeutic drugs, but in fact, the value of weak energy that supports active ingredients and the water that contains these weak energy It is important to pay attention to when discussing medicinal effects. This is because, if the human body has no water, no matter how good medicine is taken, the medicinal ingredients are not absorbed by each organ, so it is not possible to discuss only the drug body excluding water, especially water with weak energy. Because it means. Water accounts for 60% of the human body and is a medium that stores weak energy and transmits it to cells in the body. If the water in the human body is contaminated with various wastes, it is excreted as urine, but if the liver and kidneys are weak, good excretion is not performed, causing swelling of the body. However, when weak energy is given to the human body by various methods as described above, urine is excreted vigorously from the urethra (urine excretion promoting activity), and at the same time the virus is excreted (prostate treatment activity), It makes it easier to sense the commands of nerve cells transmitted from the brain (activation of the central nervous system). The principle of giving weak energy can be realized by performing a basic process while generating weak energy in water or components contained in, for example, a process of extracting the birch extract, which is a main component. For example, the gel filtration step may be performed while radiating weak energy (far infrared rays, negative ions, tourmaline energy) from the periphery of the gel filter through which the birch extract is allowed to pass in the step of extracting and separating the birch salmon active ingredient. In this case, it is recognized that the molecular weight is small. The weak energy given is also applied to the body using the active ingredient as a medium, and for example, it exerts the action of inhibiting the tissue from being acidified due to lack of energy in the body and causing the occurrence of stiffness (hyperacidity reduction activity) . Such an action is also effective for mammals other than humans, particularly livestock.

When the weak energy is further touched, the high molecular weight portion of the components extracted from the birch oyster mushroom is cut by applying the weak energy to increase the low molecular weight component, and the applied energy is held in the component. Therefore, when relatively low molecular weight increases in birch extract, it was found that bioactive effects that had not occurred in the low molecular weight region until now (before energy application) were newly discovered, and their energy The applied relatively low molecular weight component (for example, a molecular weight of 5,000 or less) is effectively absorbed into the body very quickly. In addition, oxygen, mold, and other scientific methods can be used for molecular weight cutting, and all aspects and extracts for obtaining the high-purity extract of the present invention that can be used at the same time with weak energy irradiation are included. In addition to these weak energy treatments, the digestive system is inherently weak and the molecular weight cleavage is not performed smoothly in the digestive organ. Health products such as can be provided.

The relationship between water and weak energy will be further described. Water that naturally contains energy, such as “snow water” (highly functional water developed and studied by the inventor, especially in the Nayoro region of Hokkaido. A solution of birch salmon extract of the present invention using water prepared by melting snow crystals that are fresh and free of impurities at a relatively low temperature (water obtained from snow crystallized by high energy in the sky) and natural spring water. Is effective in increasing the absorption of active ingredients in the body when taken orally. Similarly, when a high-purity extract of birch moss is put directly into the bloodstream or muscle, the liquid preparation of the present invention is prepared using snow filtered water with less impurities, and it is an active ingredient when used as an injection or infusion. The physiological activity of is enhanced. Of course, weak energy such as snow water can be applied not only to a high-purity extract but also to a birch extract without ash removal. The birch extract, which is obtained by adding the above-mentioned weak energy to snow water or medium, can be used for injections, oral preparations, in-vivo inserts for preventing and treating anti-AIDS virus, various foods, health food and drink products, cosmetics, miscellaneous goods, etc. .

The invention's effect

As described above in detail, according to the present invention, ash such as potassium and sodium is removed from a birch extract of birch moth that has many useful physiological activities such as antiviral activity, antitumor activity, immune enhancement activity, and the like. Since a high-purity liquid preparation is provided, the use of the birch extract is used as an injection solution or an infusion solution.
When high purity is required for health foods and drinks (including health drinks and foods such as health foods, noodles, and soy sauce), unnecessary components such as ash are removed to increase the effectiveness per unit, and gastrointestinal and surgery Safe drugs, beverages, and foods that do not irritate the scars can be provided, and there is an effect that a great evangelical contribution can be made not only in medical aspects but also in general health aspects. Further, by combining the snow water or birch extract with a weak energy application step, there is an effect that the effective action on the living body can be further enhanced.

Claims (12)

A method for treating a birch extract, which further enhances various physiological activities of the active ingredient by applying weak energy to the active ingredient obtained from the birch extract or in the process of obtaining the active ingredient. The weak energy application is performed by any or all of irradiation of far infrared rays or negative ions, addition of snow water, addition of electrolysis water, or electrolysis of an aqueous solution of birch extract. Processing method. The processing method according to claim 1, wherein the application of the weak energy is performed on a high-purity birch extract. The processing method according to claim 1, wherein the application of the weak energy is performed on a birch extract that does not remove or reduce ash. The processing method according to claim 2, wherein the snow water is obtained by melting fresh and clean snow. The health comprising the treatment method according to claim 2, wherein the snow water is, for example, snow after use for cooling and heating of a vegetable storage, etc., and is subjected to a treatment such as filtration to reduce contamination and purify. Food and drink products Snow water becomes an aid for (1) various products and healthy food and drink products, (2) or far infrared irradiation, (3) negative ion irradiation, (4) tourmaline energy irradiation, (5) ▼ Snow water treatment method performed by any or all of addition of electrolyzed water A health food or drink product comprising a birch salmon extract extracted from at least one of claims 2, 3, 4 and 5 used in the health food, beverage, soup and various foods described in the specification. An anti-AIDS virus solid therapeutic agent for insertion into the body, comprising a type of birch salmon extract made from one or more of the claims 2, 3, 4 and 5 as an active ingredient and including it in a capsule 8. An anti-AIDS virus therapeutic agent comprising the birch extract of 7 above as an active ingredient A mixture of various components extracted from the birch moth, which is provided with the weak energy, contains 0.01 to 99% of the total weight as an active ingredient having many physiological activities with or without removing or reducing ash. , A hairdressing or cosmetological agent consisting of an extract of birch salmon adjusted as a permanent solution Various component mixtures extracted from birch moss with weak energy applied are electrolyzed with an aqueous solution of active ingredients having many physiological activities with or without removing or reducing ash, The cosmetics according to claim 11, wherein an active ingredient is added to form an aqueous solution.