JP2009082183A - Liquid spray administration apparatus - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a liquid spray administration apparatus for discriminating the kind of a liquid when administering the liquid and monitoring the appropriate administration of the liquid to a target region inside a living body. <P>SOLUTION: The liquid spray administration apparatus 1 includes: a medical solution filling unit 2 filled with a medical solution 11a; a spray unit 3 for spraying the medical solution 11a to the lesion 12b of the living body 12a; a medical solution recognizing and monitoring mechanism 9 for recognizing the medical solution 11a in the spray unit 3 and monitoring the appropriate administration of the medical solution 11a to the lesion 12b; a voltage application unit 5 for generating an application voltage set by the medical solution recognizing and monitoring mechanism 9 corresponding to the medical solution 11a and applying the application voltage to the medical solution 11a in the spray unit 3; and a medical solution feeding mechanism 6 for feeding the medical solution 11a from the medical solution filling unit 2 to a spray nozzle 31c. The medical solution 11a is recognized before and during spraying of the medical solution 11a, and the appropriate administration to the lesion 12b is monitored. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention relates to a liquid spray administration device that sprays and administers a liquid containing a drug (for example, a drug solution) to a target site in a subject.

  In recent years, in order to efficiently administer a liquid containing a therapeutic drug solution to a desired site in a living body, such as a patient or animal, for example, a drug solution is administered from a place as close as possible to this site (affected site). It is considered desirable. In addition, for example, nucleic acid drugs that are being developed as new drugs are considered to be suitable for local administration to the affected area in view of degradation of efficacy due to in vivo metabolic degradation. As described above, it is desired that a necessary amount of a medical solution can be reliably administered to a necessary site and that side effects on a patient can be reduced.

Below, the chemical | medical solution administration method in patent document 1 is demonstrated with reference to FIG.
In such a chemical solution administration method, for example, a catheter 120 and a catheter assembly 110 for delivering a therapeutic drug (hereinafter referred to as a microparticulated therapeutic drug) that is a fine drug solution to a target site in the body, such as the heart, are disclosed. Yes. Examples of the microparticulate therapeutic agent to be delivered include an aerosol type and a dry powder type. These two types energize the microparticulate therapeutic agent by a biasing mechanism that creates a supersonic flow, transitioning the microparticulate therapeutic agent from a stationary state within the catheter 120 to a moving state toward the target site, Delivered to the heart. The urging mechanism urges the microparticulate therapeutic agent using, for example, pressurized gas, vacuum, centripetal force, plunger, potential gradient, and the like.

  A therapeutic agent with a high solids / fluid ratio is less likely to pass through the delivery lumen, so it is sometimes necessary to use a solvent to achieve a practical solids / fluid balance. Problems arise that are harmful to the target site or incompatible with the therapeutic agent.

  For this reason, Patent Document 1 provides a delivery apparatus and method for efficiently delivering a therapeutic agent that facilitates passage through a delivery lumen to a target site.

  In the delivery device, when the biasing mechanism uses a potential gradient, the catheter assembly 110 includes a catheter 120 that includes a full length lumen, a proximal end 130 including an active electrode, a counter electrode and a nozzle 180. And having a distal end 135 comprising:

The catheter assembly 110 also includes an electric energy source such as a battery or a pulse generator, and an active electrode and a counter electrode are connected to the electric energy source. The charged therapeutic agent is delivered through the active electrode, moves along the potential gradient formed by the circuit of the active electrode and the counter electrode, and reaches the target site through the nozzle 180 of the catheter 120. For example, when the therapeutic agent to be delivered is positively charged, the anode is the active electrode and the cathode is the counter electrode to complete the electrical circuit, and when the delivered therapeutic agent is negatively charged, Patent Document 1 discloses that the cathode serves as an active electrode and the anode serves as a counter electrode.
JP-T-2006-527023

  In general, there are a wide variety of chemical solutions used during disease treatment and diagnosis, and a plurality of chemical solutions may be administered for one disease. Therefore, in the above-mentioned Patent Document 1, it is proposed to use a pressurized gas, vacuum, centripetal force, plunger, potential gradient, etc., in an urging mechanism that generates a supersonic flow. It is imagined as an idea to make it applicable.

  However, if the liquid such as a chemical solution is different, the liquid characteristics such as the viscosity of the liquid itself also change, and it is necessary to change the operating conditions for administration. In particular, the dose of a drug solution or the like should be strictly controlled. If the dose is small, the drug effect does not work as expected, and if the dose is large, serious side effects occur.

  Therefore, a function of recognizing the liquid and monitoring that the liquid is properly administered to the target site is required. Furthermore, when a plurality of liquids are administered, it is desirable that the type of liquid to be administered can be discriminated so as not to use the wrong type.

  Therefore, the present invention has been made in view of these circumstances, and provides a liquid spray administration device that discriminates the type of liquid and monitors proper administration of the liquid to a target site in a living body when administering the liquid. The purpose is to do.

  In order to achieve the object of the present invention, in a liquid spray administration device that is inserted into a body and sprays and adheres an atomized liquid to a desired site in the body, a liquid filling unit that fills the liquid, and one end And a catheter having a spray port for spraying the liquid at the other end connected to the liquid filling unit and the liquid filling unit, or disposed in the vicinity of the one end, recognizing the liquid, and appropriately administering the liquid A liquid recognition / monitoring mechanism for monitoring and a voltage application that is arranged in the vicinity of the liquid filling unit or at one end, generates a voltage set by the liquid recognition / monitoring mechanism according to the liquid, and applies the voltage to the liquid And a liquid feeding mechanism for feeding the liquid applied by the voltage application unit to the spraying port.

  ADVANTAGE OF THE INVENTION According to this invention, when administering a liquid, the liquid spray administration apparatus which discriminate | determines the kind of liquid and monitors the appropriate administration of the liquid to the target site | part in a biological body can be provided.

A first embodiment according to the present invention will be described with reference to FIGS.
FIG. 1 is a schematic view of a liquid spray administration device in the present embodiment. FIG. 2 is a view showing a disposable syringe and a catheter when a chemical solution is sprayed. FIG. 3 is a flowchart showing the operation of the liquid spray administration device of this embodiment.

  As shown in FIG. 1, the liquid spray administration device 1 is filled with a liquid filling part (hereinafter, chemical liquid filling part) 2 filled with a liquid (for example, chemical liquid 11a) and a chemical liquid filling part 2 as main parts. A spray unit 3 for spraying the medicinal solution 11a to a target site (for example, an affected site 12b shown in FIG. 2) which is a desired site in the body (for example, a living body 12a such as a patient), and recognizes the medicinal solution 11a in the spray unit 3; A liquid recognition / monitoring mechanism (hereinafter referred to as “chemical solution recognition / monitoring mechanism”) 9 that monitors the proper administration of the drug solution 11a to the affected part 12b, and an applied voltage that is set by the drug solution recognition / monitoring mechanism 9 according to the drug solution 11a are generated. A voltage applying unit 5 that applies an applied voltage to the chemical solution 11a in the liquid, and a liquid feeding mechanism that feeds the chemical solution 11a applied by the voltage applying unit 5 from the chemical solution filling unit 2 to the spray port 31c in the spraying unit 3 A chemical liquid supply mechanism) 6, and a.

  The chemical solution filling unit 2 is provided with a disposable syringe 21 that is a chemical solution tank filled with the chemical solution 11a, and a piston 22 that sends the chemical solution 11a filled in the disposable syringe 21 to the catheter 31 of the spray unit 3. Yes. Here, the piston 22 moves toward the catheter 31 along the longitudinal axis direction of the disposable syringe 21, thereby feeding the liquid 11 a from the disposable syringe 21 to the catheter 31.

  The spray unit 3 is connected to the disposable syringe 21 at one end 31a, and the drug solution 11a filled in the disposable syringe 21 is sprayed (discharged, discharged) from the other end 31b inserted into the living body 12a into the living body 12a. A catheter 31 is provided. One end 31a is disposed outside the living body 12a.

  The catheter 31 has a spray port 31c that sprays the drug solution 11a as the drug particle 11b on the affected part 12b at the other end 31b. The catheter 31 is made of, for example, a non-conductive material made of tetrafluoride resin (manufactured by Teflon (registered trademark)) and has flexible flexibility. The outer diameter is approximately 0.3 mm, the inner diameter is approximately 0.1 mm, and the length is approximately. It is a thin tube having 2000 mm. The diameter of the spray port 31c is approximately 0.1 mm. As shown in FIG. 1, the catheter 31 is inserted through the forceps channel 13b of the endoscope 13a, and the spray port 31c is disposed opposite to the affected part 12b. At that time, the spray port 31c approaches or leaves the affected area 12b as the catheter 31 moves forward and backward along the insertion direction of the catheter 31.

  The chemical liquid recognition monitoring mechanism 9 is provided with a chemical liquid recognition electrode 91 that recognizes the chemical liquid 11a and a chemical liquid recognition monitoring circuit 93 that is connected to the chemical liquid recognition electrode 91 via the chemical liquid recognition electrode contact member 92.

  The chemical solution recognition electrode 91 has a circular shape made of conductive tetrafluoride resin, and is firmly joined to the one end 31a by, for example, an adhesive (not shown). Therefore, the chemical solution recognition electrode 91 is disposed outside the living body 12a. The inner diameter of the drug solution recognition electrode 91 is substantially the same as the inner diameter of the catheter 31, and the drug solution 11a contacts the inner diameter portion. The chemical solution recognition electrode 91 is an electrode that measures the electrical conductivity or resistance value of the chemical solution 11a when the chemical solution 11a in the catheter 31 contacts the inner diameter portion, and is a measurement recognition unit that recognizes the chemical solution 11a by measuring. is there. The conductivity or resistance value is an ionization characteristic in the chemical solution 11a (solution). Further, the chemical liquid recognition electrode 91 measures before the chemical liquid 11a is sprayed and when the chemical liquid 11a is sprayed.

  The chemical solution recognition monitoring circuit 93 uses the chemical solution recognition electrode contact member 92 to determine the conductivity or resistance value of the chemical solution 11a measured by the chemical solution recognition electrode 91 before and after the chemical solution 11a is sprayed. Recognize and monitor. More specifically, the chemical liquid recognition monitoring circuit 93 monitors (discriminates) whether the measured conductivity or resistance value is within a preset range or a preset threshold value or more, for example. The presence or absence of the drug solution 11a in the catheter 31 is monitored.

  When the drug solution recognition monitoring circuit 93 determines that the drug solution 11a is in the catheter 31 before the drug solution 11a is sprayed, the drug solution monitoring circuit 93 measures the drug solution measured before the drug solution 11a is sprayed. In accordance with the conductivity or resistance value of 11a, the number of rotations of a motor 61, which will be described later, when the chemical solution 11a is fed is set. Thereafter, the chemical liquid recognition monitoring circuit 93 causes the chemical liquid feeding mechanism 6 to feed the chemical liquid 11a using the set rotation speed or the like.

  Moreover, the chemical | medical solution recognition monitoring circuit 93 discriminate | determines the kind of the chemical | medical solution 11a from the chemical | medical solution 11a conductivity measured before spraying the chemical | medical solution 11a, or resistance value. Further, the chemical liquid recognition monitoring circuit 93 is a high voltage generated by the voltage application unit 5 according to the conductivity or resistance value of the chemical liquid 11a measured before the chemical liquid 11a is sprayed and applied, and is applied to the chemical liquid 11a. Set the polarity of the applied voltage to either the magnitude of the voltage, the positive polarity, or the negative polarity. Thereafter, the chemical liquid recognition monitoring circuit 93 causes the voltage application unit 5 to apply the chemical liquid 11a using the set applied voltage.

  As described above, the chemical liquid recognition monitoring circuit 93 sets the magnitude and polarity of the applied voltage, then causes the chemical liquid feeding mechanism 6 to feed the chemical liquid 11a, and applies the set voltage to the voltage application unit 5 to the chemical liquid 11a. Let

  The chemical liquid recognition monitoring circuit 93 always monitors the conductivity or resistance value as described above when the chemical liquid 11a is being sprayed. From the monitoring result, for example, when the chemical liquid 11a disappears and the conductivity or resistance value is not measured by the chemical liquid recognition electrode 91, the chemical liquid recognition monitoring circuit 93 stops the chemical liquid feeding mechanism 6 and the chemical liquid feeding mechanism 6 The liquid supply of the chemical solution 11a is stopped, the voltage application unit 5 is stopped, and the application of the chemical solution 11a by the voltage application unit 5 is stopped. That is, the chemical liquid recognition monitoring circuit 93 stops the liquid feeding and application according to the monitoring result.

  Thus, the chemical solution recognition monitoring circuit 93 monitors the electrical conductivity or resistance value of the chemical solution 11a before spraying and when sprayed, and monitors the proper administration of the chemical solution 11a from the monitoring result.

The voltage application unit 5 is provided with a voltage generation circuit 41 and a voltage application electrode 51 connected to the voltage generation circuit 41 via an electrode contact member 42.
The voltage generation circuit 41 generates a high voltage, which is an applied voltage of, for example, 1 kV or more from a power source such as a battery 15a described later, and supplies the high voltage to the voltage application electrode 51 via the electrode contact member 42. This high voltage is an applied voltage set by the chemical liquid recognition monitoring circuit 93 according to the conductivity or resistance value of the chemical liquid 11a before the chemical liquid 11a is sprayed. In this way, the voltage generation circuit 41 is set to a high voltage magnitude by the chemical liquid recognition monitoring circuit 93 according to the monitoring result. Further, the voltage generation circuit 41 is stopped from generating and supplying a high voltage by the chemical liquid recognition monitoring circuit 93 according to the monitoring result.

  The electrode contact member 42 has a tapered needle shape in the application direction in order to concentrate application of a high voltage in the voltage application electrode 51, and for example, a stainless steel electrode is preferable. The electrode contact member 42 may be a general electric contact gold-plated contact probe.

  Further, from the voltage generation circuit 41, a ground band 14 a having a 0 V potential that comes into contact with a part of the living body 12 a outside the liquid spray administration device 1 is drawn out of the liquid spray administration device 1. In the present embodiment, a part of the living body 12a is, for example, a finger 14b as shown in FIG. Thereby, the affected part 12b in the living body 12a becomes the ground. That is, the affected part 12b is a part having a different potential from the chemical solution 11a in the spray port 31c, which is a part to which a high voltage is applied.

  Further, for example, a high resistance circuit (not shown) is incorporated in the voltage generation circuit 41 as a high voltage safety measure. As a high resistance circuit, a high resistance for protection that prevents sparks and electric shock to the living body 12a is arranged in series on the electrode contact member 42.

  The voltage generation circuit 41 may be provided with a transformer (not shown) that boosts (generates) a power source such as the battery 15a to a high voltage.

In addition, the voltage generation circuit 41 may be provided with a storage unit (not shown) that stores a table that stores preset combinations of applied voltage magnitudes, application durations, and the like. The application duration is, for example, an application time during which a high voltage is supplied to the voltage application electrode 51 and a high voltage is applied to the drug solution 11a with respect to the voltage application electrode 51. When the voltage generation circuit 41 supplies a high voltage to the voltage application electrode 51, the voltage generation circuit 41 calls a table according to the use application of the chemical solution 11a, and defines at least one of the magnitude of the application voltage and the application duration corresponding to the use application. May be.
In addition, when the magnitude of the applied voltage changes, the diameter of the chemical fine particles 11b changes.

  The voltage application electrode 51 is an electrode that applies a high voltage supplied from the voltage generation circuit 41 through the electrode contact member 42 to the drug solution 11 a in the catheter 31. Specifically, the voltage application electrode 51 applies a high voltage to the drug solution 11 a in the spray port 31 c via the drug solution 11 a in the catheter 31. Thereby, the chemical solution 11a is sprayed from the spray port 31c as charged and atomized fine particles (chemical solution fine particles 11b). At that time, when the high voltage is set to the + side polarity by the chemical liquid recognition monitoring circuit 93, the chemical liquid particle 11 b is charged to the + side polarity, and the high voltage is set to the − side polarity by the chemical liquid recognition monitoring circuit 93. The chemical fine particles 11b are charged to the negative polarity. In general, the living body 12a is in the vicinity of 0V, and in the present embodiment, the living body 12a is at 0V due to the ground band 14a. Therefore, the liquid 11a (charged liquid fine particles 11b) in the living body 12a and the spray port 31c is at a potential. Is different. Therefore, the chemical liquid fine particles 11b charged to the positive side polarity or the one side polarity are positively attached to the affected part 12b of the living body 12a, which is a site having a different potential from the chemical liquid 11a in the spray port 31c.

The voltage application electrode 51, like the chemical solution recognition electrode 91, has a circular pipe shape made of conductive tetrafluoride resin, and is firmly joined to the one end 31a by, for example, an adhesive (not shown). Therefore, the voltage application electrode 51 is disposed outside the living body 12a. The inner diameter of the voltage application electrode 51 is substantially the same as the inner diameter of the catheter 31, and the drug solution 11a contacts the inner diameter portion. The voltage application electrode 51 applies a high voltage to the drug solution 11a when the drug solution 11a in the catheter 31 contacts the inner diameter portion.
The voltage application electrode 51 is detachable from the electrode contact member 42. Further, the voltage application electrode 51 and the disposable syringe 21 are fastened by screwing and are detachable. That is, the constituent member by the disposable syringe 21 and the piston 22, the constituent member by the catheter 31, the voltage application electrode 51, the chemical solution recognition electrode 91, and the insulating member 19 to be described later can be attached and detached, and used as a disposable part depending on the case. Discarded later.

  The voltage application electrode 51 is disposed closer to the disposable syringe 21 than the drug solution recognition electrode 91 in the insertion direction of the catheter 31. Between the voltage application electrode 51 and the chemical solution recognition electrode 91, an insulating member 19 that electrically insulates each other is disposed. The insulating member 19 may be made of a non-conductive material made of the same material as the catheter 31 and made of tetrafluoride resin (made of Teflon).

  The chemical solution feeding mechanism 6 is engaged with a motor 61 that is a drive unit, a control circuit 62 that controls the motor 61, a ball screw 63 that is connected to the motor 61 and to which the rotational movement of the motor 61 is transmitted, and the ball screw 63. A movable part that is detachable from the piston 22 and moves along the ball screw 63 by transmitting the rotational movement of the motor 61 from the ball screw 63, thereby moving the piston 22 along the longitudinal axis direction of the disposable syringe 21. 64 is provided.

  The control circuit 62 controls the amount of the chemical solution 11a sent from the disposable syringe 21 to the spray port 31c by controlling the number of rotations of the motor 61, and controls the rotational speed of the motor 61 from the disposable syringe 21 to the spray port. The liquid feeding speed of the chemical solution 11a fed to 31c is controlled. The control circuit 62 controls, for example, the rotational speed and rotational speed of the motor 61 based on the set value set by the chemical liquid recognition monitoring circuit 93. The motor 61 rotates based on an instruction from the control circuit 62, moves the movable portion 64 via the ball screw 63, and moves the piston 22 toward the catheter 31 along the longitudinal axis direction of the disposable syringe 21. Thereby, the chemical | medical solution 11a is sent to the one end 31a from the disposable syringe 21, is applied with the voltage application electrode 51, and is sent to the spraying port 31c from the one end 31a. The liquid 11 a to be fed is applied by the voltage application electrode 51. Specifically, the chemical solution 11a is fed from the disposable syringe 21 to the one end 31a, applied by the voltage application electrode 51, and fed from the one end 31a to the spray port 31c.

  The chemical liquid feeding mechanism 6 performs this liquid feeding after the chemical liquid recognition monitoring mechanism 9 sets the magnitude of the applied voltage. Further, the chemical solution feeding mechanism 6 can be stopped by the chemical solution recognition monitoring mechanism 9 according to the monitoring result. That is, in the control circuit 62, the rotation of the motor 61 is stopped by the chemical liquid recognition monitoring circuit 93 according to the monitoring result.

  The control circuit 62 may be input with, for example, the number of rotations of the motor 61 designated by the user. As described above, the rotational speed or the like may be set by the chemical liquid recognition monitoring circuit 93 or may be designated by the user.

In addition, the control circuit 62 stores a combination of a preset amount of the liquid medicine 11a (the number of rotations of the motor 61) and a speed of the liquid medicine 11a (the rotation speed of the motor 61) from the disposable syringe 21 to the spray port 31c. It is also possible to have a storage unit (not shown) that stores the table being stored. When feeding the chemical solution 11a, the control circuit 62 may call up a table according to the use application of the chemical solution 11a and define at least one of the liquid supply amount and the liquid supply speed corresponding to the use application.
When the liquid feeding speed is changed, the diameter of the chemical liquid fine particles 11b is changed.

  Electric power is supplied from the battery 15 a to the chemical solution feeding mechanism 6, the voltage generation circuit 41, and the chemical solution recognition monitoring circuit 93.

  The chemical solution feeding mechanism 6, the voltage generation circuit 41, the electrode contact member 42, the chemical solution recognition electrode contact member 92, the chemical solution recognition monitoring circuit 93, and the battery 15a are built in the housing 15b. Disposable syringe 21 filled with medicinal liquid 11a, piston 22, voltage application electrode 51, medicinal liquid recognizing electrode 91, and catheter 31 are connected and inserted into disposable syringe fixing frame 15c, which is an electrically insulating portion such as rubber, for example. Is connected to the movable part 64 to constitute the liquid spray administration device 1.

  Inside the disposable syringe fixing frame 15 c, the voltage application electrode 51 is connected to the electrode contact member 42, and the chemical solution recognition electrode 91 is connected to the chemical solution recognition electrode contact member 92. Therefore, the voltage application electrode 51 and the electrode contact member 42, and the chemical solution recognition electrode 91 and the chemical solution recognition electrode contact member 92 are prevented from contacting the outside by the disposable syringe fixing frame 15c and the housing 15b.

  A display unit 20a such as a liquid crystal display or LED, and a sound generation unit 20b such as a speaker are disposed on the upper part of the disposable syringe fixing frame 15c. The display unit 20a and the sound generation unit 20b clearly indicate alarm information from the chemical solution feeding mechanism 6, the voltage generation circuit 41, and the chemical solution recognition monitoring mechanism 9 to the outside.

The alarm information is, for example, that the chemical solution 11a is a liquid that easily conducts electricity when the conductivity measured by the chemical solution recognition and monitoring mechanism 9 exceeds the preset range described above. This is information (warning) indicating that it has an influence.
The alarm information means that, for example, when the electrical conductivity measured by the chemical liquid recognition / monitoring mechanism 9 falls below a preset range, the chemical liquid 11a cannot be fed, or bubbles such as air are included in the chemical liquid 11a. This is information indicating that the
Thereby, the display unit 20a and the sound generation unit 20b clearly indicate to the user that the liquid spray administration device cannot administer the drug solution 11a.

  In addition, an openable / closable transparent resin cover 15d that prevents the fingers 14b and the like from being caught is disposed in a portion where the piston 22 moves.

  In the present embodiment, the disposable syringe 21, the piston 22, the insulating member 19, the catheter 31, the voltage application electrode 51, and the chemical solution recognition electrode 91 are the electrode contact member 42 that is the voltage application unit 5 and the movable part that is the chemical solution feeding mechanism 6. 64 and the chemical solution recognition electrode contact member 92 which is the chemical solution recognition monitoring mechanism 9 are detachable, and are discarded as disposable parts after use depending on the case.

  Therefore, as described above, when the disposable syringe 21, the piston 22, the insulating member 19, the catheter 31, the voltage application electrode 51, and the chemical solution recognition electrode 91 are discarded after use, the voltage application unit 5, the chemical solution feeding mechanism 6, and the chemical solution recognition monitoring are performed. The mechanism 9, the battery 15a, the casing 15b, the disposable syringe fixing frame 15c, the cover 15d, and the like are connected to, for example, an unused disposable syringe 21, piston 22, insulating member 19, catheter 31, voltage application electrode 51, and chemical recognition electrode 91. However, it can be reused as a reuse part.

Next, an operation method according to this embodiment will be described.
First, a method for discharging the chemical solution 11a will be described.
The high voltage generated from the voltage generation circuit 41 is supplied to the voltage application electrode 51 through the electrode contact member 42. This high voltage is applied to the drug solution 11 a in the catheter 31 by the voltage application electrode 51. That is, a high voltage is applied to the drug solution 11 a in the catheter 31.

As shown in FIG. 2, the applied chemical solution 11a in the spray port 31c is sprayed from the spray port 31c as atomized charged fine chemical particles 11b.
In detail, the chemical | medical solution 11a in the spraying opening 31c forms the interface in a liquid and gas between external air. When voltage acts on this interface, the interface becomes unstable in electrohydrodynamics due to the electrostatic force acting on the surface of the chemical solution 11a, and an unstable point is generated. Atomized chemical liquid particles 11b charged from this unstable point are sprayed. When a high voltage acts on the interface and the electric field density at the interface at the spray port 31c reaches a critical value, a thin liquid thread is drawn from the surface of the chemical solution 11a, and the liquid thread expands and contracts. At this time, the chemical solution 11a splits from the thin liquid yarn as a large number of chemical solution fine particles 11b from the tip of the liquid yarn. Further, when the value of the high voltage is increased, the interface in the thin liquid yarn becomes more unstable, and a large number of unstable points are generated simultaneously. From these unstable points, a large amount of the chemical solution 11a is sprayed from the spray port 31c as charged and completely atomized chemical solution fine particles 11b.

  Since the catheter 31 is made of a non-conductive material made of tetrafluoride resin, the drug solution 11 a is sprayed without staying in the catheter 31.

  As described above, when a high voltage is applied to the drug solution 11a, a potential difference is generated between the drug solution 11a at the spray port 31c and the living body 12a. That is, the voltage generation circuit 41 generates a high voltage and applies a high voltage to the drug solution 11a, thereby generating a potential difference between the drug solution 11a and the living body 12a at the spray port 31c. At this time, electric lines of force 16 as shown in FIG. 2 are formed from the spray port 31c toward the living body 12a. The above-described medicinal solution fine particles 11b that are sprayed and charged are in accordance with the electric force lines 16 from the spray port 31c and are portions having different potentials from the medicinal solution 11a in the spray port 31c, and within the range in which the electric force lines 16 are formed. Is appropriately administered toward the living body 12a. At that time, the charged chemical fine particles 11b adhere to the living body 12a having a potential of 0V. That is, the drug solution 11a is appropriately administered only to the affected part 12b in the living body 12a, which is a site having a different potential from the drug solution 11a in the spray port 31c, as the drug fine particles 11b.

  Thus, the medicinal solution 11a is appropriately administered to the affected part 12b in the living body 12a regardless of the gas pressure. Further, since the chemical liquid fine particles 11b are charged, the chemical liquid fine particles 11b reliably adhere to the affected part 12b without rising from the affected part 12b. Moreover, the chemical | medical solution 11a is not atomized in the disposable syringe 21 or the catheter 31, and is not sent to the spray port 31c in the atomized state. Moreover, gas pressure is not used for administration to the affected part 12b of the chemical | medical solution 11a. In the present embodiment, the drug solution 11 a is filled in the catheter 31, atomized at the spray port 31 c, and administered to the affected part 12 b according to the electric force lines 16. Therefore, it can prevent that the chemical | medical solution 11a remains in the catheter 31, and it can prevent that the quantity administered by diffusing by gas pressure and being administered to the affected part 12b decreases. Moreover, it is prevented that the chemical | medical solution 11a droops from the spraying nozzle 31c, and adheres to sites other than the affected part 12b. Therefore, the drug solution 11a is appropriately administered to the affected part 12b in the living body 12a.

Next, an operation method of the liquid spray administration device in the present embodiment will be described with reference to FIG.
The disposable syringe 21 is fastened by screwing with the voltage application electrode 51 and integrated with the catheter 31 (Step 1).

  A desired amount of the chemical solution 11a is filled in the disposable syringe 21, and the piston 22 is disposed in the disposable syringe 21 (Step 2).

  The disposable syringe 21, the voltage application electrode 51, the chemical solution recognition electrode 91, and the catheter 31 are connected to each other and then inserted into the disposable syringe fixing frame 15c, and the piston 22 is connected to the movable portion 64 disposed in the housing 15b. The voltage application electrode 51 is connected to the electrode contact member 42, and the chemical solution recognition electrode 91 is connected to the chemical solution recognition electrode contact member 92. After the disposable syringe 21 is thus arranged on the housing 15b, the cover 15d is closed. Thus, the liquid spray administration device 1 is configured (Step 3).

  The liquid spray administration device 1 rotates the motor 61 in the control circuit 62 when an operation start is instructed by a user by an operation start switch (not shown) or the like. As a result, the piston 22 moves to the catheter 31 side along the longitudinal axis of the disposable syringe 21, and pushes the drug solution 11a filled in the disposable syringe 21 to the catheter 31 side. At this time, only the reference amount of the chemical solution 11a is fed from the disposable syringe 21 to the one end 31a side. The reference amount is an amount that the chemical solution 11a contacts the voltage application electrode 51 and the chemical recognition electrode 91. At this time, the chemical solution 11a does not reach the spray port 31c. After the reference amount is fed, the control circuit 62 stops the motor 61 once. (Step 4).

  Next, before the reference amount of the drug solution 11a is sprayed, the conductivity or resistance value of the reference amount of the drug solution 11a is measured by the drug solution recognition electrode 91. Then, it is determined by the chemical solution recognition monitoring circuit 93 whether the conductivity or resistance value is within a preset range, for example, and the presence or absence of the chemical solution 11a is monitored (discriminated). That is, before the reference amount of the drug solution 11a is spray-administered, the drug solution recognition monitoring circuit 93 determines whether the conductivity or the resistance value is measured (Step 5).

  In Step 5, when it is determined from the measurement result that there is no chemical solution 11a, for example, by the chemical solution recognition monitoring circuit 93 (conductivity or resistance value is not measured by the chemical solution recognition electrode 91) (Step 5: No), the chemical solution is fed. Alarm information from the liquid mechanism 6, the voltage generation circuit 41, and the chemical liquid recognition / monitoring mechanism 9 is clearly indicated to the outside by the display unit 20a and the sound generation unit 20b (Step 6). Thereby, operation | movement of the liquid spray administration apparatus 1 is complete | finished.

  In such a case, for example, the reference amount of the chemical solution 11a includes a large number of bubbles such as air, and the conductivity or resistance value of the chemical solution 11a is not measured by the chemical solution recognition electrode 91 due to the bubbles. As a result, the reference amount of the chemical solution 11a is retransmitted.

Further, in Step 5, when it is determined from the measurement result that the chemical liquid 11a is present, for example, by the chemical liquid recognition monitoring circuit 93 (conductivity or resistance value is measured by the chemical liquid recognition electrode 91) (Step 5: Yes), the chemical liquid 11a. Is determined by the chemical liquid recognition monitoring circuit 93 based on the conductivity or the resistance value. Further, the chemical liquid recognition monitoring circuit 93 sets the optimum magnitude of applied voltage, the number of rotations of the motor 61, etc. according to the determined conductivity or resistance value of the chemical liquid 11a.
The set magnitude of the applied voltage is output to the voltage generation circuit 41 in the voltage application unit 5 by the chemical liquid recognition monitoring circuit 93. At the same time, an instruction to supply the applied voltage to the voltage application electrode 51 is output from the chemical liquid recognition monitoring circuit 93 to the voltage generation circuit 41. The set number of rotations of the motor 61 is output to the control circuit 62 in the chemical solution feeding mechanism 6 by the chemical solution recognition monitoring circuit 93. At the same time, an instruction to rotate the motor 61 is output from the chemical liquid recognition monitoring circuit 93 to the control circuit 62. The voltage generation circuit 41 is input with an application duration time designated by the user, for example. For example, the number of rotations of the motor 61 designated by the user may be input to the control circuit 62. Thus, the operating conditions are set (Step 7).

  In Step 7, if there is no designation by the user, the voltage generation circuit 41 or the control circuit 62 selects the table call stored in the storage unit, the application duration corresponding to the intended use, the rotation speed of the motor 61, and the like. Also good.

  The catheter 31 is inserted through the forceps channel 13b of the endoscope 13a. While the affected part 12b is observed by an observation optical system (not shown) provided in the endoscope 13a, the spray port 31c is positioned so as to face the affected part 12b (Step 8).

  When the liquid spray administration apparatus 1 is instructed to start the operation by an operation start switch (not shown) or the like, the control circuit 62 rotates the motor 61 at the set rotation speed or the like. As a result, the piston 22 moves along the longitudinal axis of the disposable syringe 21 toward the catheter 31, and pushes the drug solution 11 a filled in the disposable syringe 21 onto the catheter 31. At this time, only a desired amount of the chemical solution 11a is sent from the disposable syringe 21 to the spray port 31c (Step 9).

  The high voltage supplied from the voltage generation circuit 41 is applied to the chemical solution 11a by the voltage application electrode 51 via the electrode contact member 42 (Step 10). The chemical solution 11a is applied with this high voltage only for the duration of application.

  As a result, the drug solution 11a is sprayed from the spray port 31c as charged drug solution fine particles 11b, and is administered to and adheres to the affected part 12b (Step 11). Since the operation in Step 11 is the above-described method of discharging the chemical solution 11a, the details are omitted.

  When the chemical liquid 11a is being fed by the chemical liquid feeding mechanism 6, it is determined by the chemical recognition monitoring circuit 93 whether a desired amount of the chemical liquid 11a has been fed (Step 12). The chemical liquid recognition monitoring circuit 93 makes a determination based on, for example, the number of rotations of the motor 61.

  In Step 12, when the chemical liquid recognition monitoring circuit 93 determines that the desired amount of the chemical liquid 11a has been fed (Step 12: Yes), the chemical liquid recognition monitoring circuit 93 causes the control circuit 62 to stop the motor 61 and the piston 22 Stop moving. Accordingly, the feeding of the chemical solution 11a is stopped by the chemical solution feeding mechanism 6 (Step 13).

  In addition, the chemical liquid recognition monitoring circuit 93 causes the voltage generation circuit 41 to stop supplying a high voltage to the voltage application electrode 51 through the electrode contact member 42. Thereby, application of the high voltage with respect to the chemical | medical solution 11a stops by the voltage application part 5 (Step14). And operation | movement of the liquid spray administration apparatus 1 is complete | finished.

  Further, in Step 12, when the chemical solution 11a of the desired amount is not being delivered (the desired amount is being delivered) and determined by the chemical recognition monitor circuit 93 (Step 12: No), similarly to Step 5, The presence or absence of the chemical solution 11a is monitored (discriminated). That is, when the medicinal solution 11a is sprayed, the medicinal solution recognition monitoring circuit 93 determines whether the conductivity or the resistance value is measured by the medicinal solution recognition electrode 91 (Step 15).

In Step 15, when the chemical liquid recognition monitoring circuit 93 determines that there is no chemical liquid 11 a from the measurement result (Step 15: No), the chemical liquid recognition monitoring circuit 93 stops the motor 61 in the control circuit 62 and moves the piston 22. Stop.
Such determination is made, for example, when the electrical conductivity or the resistance value is not measured by the chemical liquid recognition electrode 91 due to bubbles or the like, or the chemical liquid 11a to be fed is not yet supplied, but in other words, This is a case where the filling amount of the drug solution 11a is wrong and the amount of the drug solution 11a to be sprayed is small. Thereby, the feeding of the chemical solution 11a is stopped by the chemical solution feeding mechanism 6 in the same manner as in Step 13 (Step 16).

  In addition, the chemical liquid recognition monitoring circuit 93 causes the voltage generation circuit 41 to stop supplying a high voltage to the voltage application electrode 51 through the electrode contact member 42. Thereby, the application of the high voltage with respect to the chemical | medical solution 11a stops by the voltage application part 5 similarly to Step14 (Step17).

  Further, the alarm information is clearly indicated to the outside by the display unit 20a and the sound generation unit 20b as in Step 6 (Step 18). Thereby, operation | movement of the liquid spray administration apparatus 1 is complete | finished.

  Further, in Step 15, when the chemical liquid recognition monitoring circuit 93 determines that there is, for example, the chemical liquid 11a from the measurement result (Step 15: Yes), the process returns to Step 9, the liquid supply of the chemical liquid 11a is continued, and the spray administration is continued.

  As described above, the chemical liquid recognition monitoring mechanism 9 causes the chemical liquid recognition electrode 91 to measure the conductivity or resistance value of the chemical liquid 11a before the chemical liquid 11a is sprayed, and causes the chemical liquid recognition monitoring circuit 93 to measure the conductivity or resistance value. The presence or absence of the chemical solution 11a is monitored (discriminated).

  Next, the chemical solution recognition / monitoring mechanism 9 causes the chemical solution recognition monitoring circuit 93 to determine the type of the chemical solution 11a to be used, and optimizes the conductivity of the chemical solution 11a to be administered, the magnitude of the applied voltage with respect to the resistance value, and the rotation speed of the motor 61. To set proper operating conditions. Thereby, liquid feeding and application start.

  Further, when the chemical solution 11a is sprayed, the chemical solution recognition monitoring mechanism 9 causes the chemical solution recognition electrode 91 to always measure the conductivity or resistance value of the chemical solution 11a and causes the chemical solution recognition monitoring circuit 93 to monitor. Accordingly, the drug solution 11a is reliably delivered to the affected part 12b, which is the affected part 12b of the living body 12a, while monitoring proper administration.

  For example, when the drug solution 11a filled in the disposable syringe 21 is used by dissolving a solid agent in a solution, the drug solution recognition monitoring mechanism 9 applies the drug solution 11a to the drug solution recognition electrode 91 before the drug solution 11a is sprayed. Is measured, and the chemical solution recognition monitoring circuit 93 monitors it to determine whether or not the solid agent is uniformly dissolved in the solution.

  If the solid agent is not uniformly dissolved in the solution, the concentration will change, and the conductivity or resistance value of the chemical solution 11a will change. Therefore, when the conductivity or resistance value exceeds the preset range, the solid agent is not uniformly dissolved in the solution, and the chemical solution recognition monitoring mechanism 9 sends alarm information to the display unit 20a and the sound generation unit 20b. Make it explicit.

  Further, when the drug solution 11a is sprayed and administered, if the solid agent is not uniformly dissolved in the solution locally in the drug solution 11a, the conductivity or resistance value of the drug solution 11a changes as described above. Therefore, the solid agent is not uniformly dissolved in the solution, and the chemical liquid recognition monitoring mechanism 9 stops the liquid supply mechanism 6 to stop the liquid supply, and the voltage application unit 5 stops the generation and supply of the high voltage to display. Alarm information is clearly indicated in the unit 20a and the sound generation unit 20b.

  Further, for example, when air is mixed into the chemical liquid 11a before the chemical liquid 11a is sprayed or when the chemical liquid 11a is sprayed, the chemical liquid recognition monitoring circuit 93 is instantly contacted with the chemical liquid recognition electrode 91. The change in conductivity or resistance value of the chemical solution 11a is captured. Therefore, the chemical liquid recognition monitoring mechanism 9 stops the liquid supply mechanism 6 to stop liquid supply as described above, stops the voltage application unit 5 from generating and supplying high voltage, and sends alarm information to the display unit 20a and the sound generation unit 20b. Make it explicit.

  Thus, this embodiment can discriminate | determine the kind of chemical | medical solution to be used, for example, when administering several chemical | medical solution 11a, and can monitor the appropriate administration of the chemical | medical solution 11a to the affected part 12b of the biological body 12a. Moreover, this embodiment can select the appropriate dosage of each chemical | medical solution 11a by setting an operating condition optimally, and can reduce a drug efficacy fall and a side effect.

  Further, in the present embodiment, when the drug solution 11a is used by dissolving a solid agent in a solution, whether or not the solid agent is uniformly dissolved in the solution is determined before and after the spray administration. By making the chemical solution recognition electrode 91 measure the electrical conductivity or resistance value of the chemical solution 11a, it can always be determined. Thereby, this embodiment can monitor appropriate administration of the chemical | medical solution 11a to the affected part 12b of the biological body 12a.

  Moreover, this embodiment can catch the change of electrical conductivity or resistance value besides the electrical conductivity or resistance value of the chemical | medical solution 11a. For example, as described above, even if air is mixed into the chemical solution 11a for some reason during the liquid feeding operation, the chemical solution 11a is detected by the chemical solution recognition monitoring circuit 93 at the moment when the air contacts the chemical recognition electrode 91. The change in conductivity or resistance value can be captured.

  Therefore, in this embodiment, since the chemical solution recognition monitoring circuit 93 can always monitor the concentration abnormality of the chemical solution 11a and the administration abnormality due to air mixing, the proper administration of the chemical solution 11a to the affected part 12b of the living body 12a can be maintained.

  Further, when air is mixed, the electric field applied to the spray port 31c in the catheter 31 is cut off, and spraying stops. It is important to detect the air layer in order to perform accurate drug administration. In the present embodiment, an air layer can be detected, and at that time, liquid feeding can be stopped. Therefore, this embodiment can perform appropriate administration of the chemical | medical solution 11a to the affected part 12b in the biological body 12a by removing liquid again after removing air.

  In addition, when different chemical solutions 11a are continuously administered, in the present embodiment, the chemical solution recognition monitoring circuit 93 in the chemical solution recognition monitoring mechanism 9 determines the magnitude of the optimum applied voltage with respect to the conductivity or resistance value of each chemical solution 11a. Can be set. Therefore, this embodiment can perform appropriate administration of the chemical | medical solution 11a to the affected part 12b of the biological body 12a reliably each chemical | medical solution 11a.

For example, if the range of the electrical conductivity of the chemical solution 11a is within the range of 1 × 10 ⁻¹⁰ (S / m) to 1 × 10 ⁻¹ (S / m), the present embodiment recognizes the chemical solution in the chemical solution recognition monitoring mechanism 9. By changing at least one of the magnitude of the applied voltage set by the monitoring circuit 93 and the liquid feeding speed of the chemical solution 11a, the diameter of the chemical fine particles 11b can be made variable.
For example, in the present embodiment, the diameter of the chemical liquid fine particles 11b can be reduced by increasing the applied voltage.
For example, this embodiment can shorten the time which an unstable point generate | occur | produces by enlarging liquid feeding speed. As a result, since the chemical liquid fine particles 11b are sprayed in a state before being completely atomized, the diameter of the chemical fine particles 11b is increased. Therefore, in this embodiment, the diameter of the chemical liquid fine particles 11b can be increased by increasing the liquid feeding speed. Moreover, this embodiment can make the diameter of the chemical | medical solution microparticles | fine-particles 11b small by making the hole diameter of the spray port 31c small.
Thereby, this embodiment can select the optimal diameter of the chemical liquid particle 11b according to the affected area 12b, determine the type of the chemical liquid, monitor proper administration, and administer the chemical liquid fine particle 11b having the optimal diameter to the affected area 12b. can do.

In the present embodiment, for example, the chemical solution 11a is distilled water having a conductivity of 1 × 10 ⁻⁶ (S / m), the diameter of the spray port 31c is approximately 0.1 mm, the applied voltage is approximately +5 kV, and the liquid feeding speed. Is approximately 0.1 mL / min, the drug solution 11a having a diameter of approximately 20 μm to approximately 60 μm can be appropriately administered to the affected part 12b in the living body 12a while monitoring the drug solution 11a being used.
In the present embodiment, for example, the chemical solution 11a is a physiological saline having a conductivity of 1.4 × 10 ⁻² (S / m), the diameter of the spray port 31c is approximately 0.05 mm, and the applied voltage is approximately +10 kV. When the liquid feeding speed is approximately 0.05 mL / min, it is possible to appropriately administer the drug solution fine particles 11b having a diameter of approximately 5 μm to approximately 20 μm to the affected part 12b in the living body 12a while monitoring the drug solution 11a being used. it can.
In this embodiment, for example, the chemical solution 11a is a PBS solution having a conductivity of 1.3 × 10 ⁻² (S / m), the diameter of the spray port 31c is approximately 0.5 mm, the applied voltage is approximately +5 kV, When the liquid speed is about 0.3 mL / min, the chemical liquid particles 11b having a diameter of about 200 μm to about 300 μm can be appropriately administered to the affected part 12b in the living body 12a while monitoring the used chemical liquid 11a. .

  When the applied voltage is positive polarity, the chemical liquid 11a becomes a chemical fine particle 11b charged to the positive polarity, and when the applied voltage is negative polarity, the chemical liquid 11a is the same as the chemical fine particle 11b charged to the negative polarity. Become. In general, the living body 12a is in the vicinity of 0V, and in the present embodiment, the living body 12a is set to 0V by the ground band 14a. Therefore, the charged chemical liquid particles 11b are positively attached to the affected part 12b of the living body 12a. . Thus, since the chemical | medical solution microparticles | fine-particles 11b do not rise from the biological body 12a, this embodiment can manage dosage accurately.

  Further, in this embodiment, as shown in FIG. 1, the catheter 31 is inserted into the forceps channel 13b of the endoscope 13a, the catheter 31 is moved forward and backward along the insertion direction of the catheter 31, and the affected part 12b is observed by the observation optical system. However, the drug solution can be administered while recognizing the administration position.

  In the present embodiment, the disposable syringe 21 and the voltage application electrode 51 are fastened by screwing, and the disposable syringe 21 can be attached to and detached from the catheter 31. That is, the constituent member by the disposable syringe 21 and the piston 22, the voltage applying electrode 51, the insulating member 19, the chemical solution recognition electrode 91, and the constituent member by the catheter 31 can be attached and detached. Therefore, when two or more types of drug solutions 11a are administered, in the present embodiment, only the disposable syringe 21 filled with the drug solution 11a may be replaced with the catheter 31 disposed in the living body 12a. At this time, the present embodiment can be operated by changing an appropriate operating condition in accordance with the electrical conductivity or the resistance value, which is an electrical characteristic of the replaced chemical solution 11a.

  The chemical solution recognition electrode 91 and the voltage application electrode 51 may be arranged outside the body and in a place where the chemical solution recognition electrode 91 can come into contact with the chemical solution 11a. For example, the chemical solution recognition electrode 91 and the voltage application electrode 51 may be arranged in the vicinity of the one end 31a.

Next, a second embodiment according to the present invention will be described with reference to FIG. In addition, about the structure same as 1st Embodiment, description is abbreviate | omitted by attaching | subjecting the same referential mark as 1st Embodiment. FIG. 4 is a flowchart showing the operation of the liquid spray administration device in the present embodiment.
The chemical solution recognition / monitoring circuit 93 in the present embodiment generates a pulse voltage having a prescribed magnitude, for example, having a voltage value of 5 kV and an application time of 100 msec. This pulse voltage is supplied to the chemical solution recognition electrode 91 via the chemical solution recognition electrode contact member 92. The chemical solution recognition electrode 91 instantaneously applies a pulse voltage to the chemical solution 11a and measures the current value at that time.

  From this current value, the chemical solution recognition / monitoring circuit 93 according to the present embodiment determines the presence / absence of the chemical solution 11a, the type of the chemical solution 11a, the setting of the magnitude of the applied voltage, the setting of the number of rotations of the motor 61, and the like. Do. As described above, the chemical liquid recognition monitoring circuit 93 of the present embodiment monitors the chemical liquid 11a using the current value instead of the conductivity or the resistance value.

Next, an operation method of the liquid spray administration device in the present embodiment will be described with reference to FIG.
In the present embodiment, Step 5 shown in FIG. 3 is replaced with Step 21, Step 15 shown in FIG. 3 is replaced with Step 22, and each of the other Steps is the same as that of the first embodiment, and detailed description thereof is omitted.

  Before the drug solution 11a is sprayed, a pulse voltage is generated from the drug solution recognition monitoring circuit 93 and supplied to the drug solution recognition electrode 91 via the drug solution recognition electrode contact member 92. The drug solution recognition electrode 91 supplies a reference amount of the drug solution 11a. Is instantaneously applied. The current value at that time is measured by the chemical liquid recognition electrode 91. Whether or not the current value is within a preset range is determined by the chemical liquid recognition monitoring circuit 93, and the presence or absence of the chemical liquid 11a is monitored (discriminated). That is, the chemical liquid recognition monitoring circuit 93 determines whether or not the current value is measured before the reference amount of the chemical liquid 11a is sprayed (Step 21).

  In Step 21, when it is determined from the measurement result that there is no chemical solution 11 a, for example, by the chemical recognition monitor circuit 93 (the current value was not measured by the chemical recognition electrode 91 due to bubbles or the like) (Step 21: No), the process proceeds to Step 6. .

  In Step 21, when the chemical liquid recognition monitoring circuit 93 determines that the chemical liquid 11 a is present from the measurement result (Step 21: Yes), the type of the chemical liquid 11 a is determined by the chemical liquid recognition monitoring circuit 93. Further, the chemical liquid recognition monitoring circuit 93 sets the optimum magnitude of the applied voltage corresponding to the current value of the chemical liquid 11a, the rotation speed of the motor 61, and the like.

  Further, in Step 12, when the chemical liquid recognition monitoring circuit 93 determines that the desired amount of the chemical liquid 11a has not been fed (Step 12: No), the presence or absence of the chemical liquid 11a is monitored (discriminated) as in Step 21. . That is, when the medicinal solution 11a is sprayed, the medicinal solution recognition monitoring circuit 93 determines whether the current value is measured by the medicinal solution recognition electrode 91 (Step 22).

  In Step 21, when it is determined from the measurement result that, for example, there is no chemical solution 11 a by the chemical recognition monitor circuit 93 (the current value was not measured by the chemical recognition electrode 91 due to bubbles or the like) (Step 22: No), the process proceeds to Step 16. .

  In Step 21, when it is determined from the measurement result that the drug solution 11 a is present, for example, by the drug solution recognition monitoring circuit 93 (Step 22: Yes), the process returns to Step 9.

As described above, the present embodiment can obtain the same effect as that of the first embodiment even when the current value is used.
In addition, when air is mixed, the electric field applied to the spray port 31c by the air layer in the catheter 31 is cut off, and the current value rapidly decreases, and spraying stops. It is important to detect the air layer in order to perform accurate drug administration. In the present embodiment, an air layer can be detected, and at that time, liquid feeding can be stopped. Therefore, this embodiment can perform appropriate administration of the chemical | medical solution 11a to the affected part 12b in the biological body 12a by removing liquid again after removing air.

  Furthermore, when the chemical liquid 11a does not become the chemical liquid fine particles 11b for some reason, the chemical liquid 11a becomes a water column between the spray port 31c and the living body 12a and easily comes into contact with each other. At this time, the current value generally tends to increase. The chemical liquid recognition monitoring circuit 93 captures a change in the current value, stops the chemical liquid supply mechanism 6 from supplying the chemical liquid 11a, and stops the voltage application unit 5 from generating and supplying a high voltage. As described above, according to the present embodiment, it is possible to recognize and monitor whether or not the atomization is reliably generated from the spray port 31c in the living body 12a by the chemical liquid recognition monitoring circuit 93 based on the current value.

  In the present embodiment, the chemical liquid recognition electrode 91 and the voltage application electrode 51 may have the same configuration. Moreover, the chemical | medical solution recognition monitoring circuit 93 in this embodiment may monitor an electric current value, monitoring the electrical conductivity in 1st Embodiment, or resistance value.

  Next, a third embodiment according to the present invention will be described with reference to FIG. In addition, about the structure same as 1st Embodiment, description is abbreviate | omitted by attaching | subjecting the same referential mark as 1st Embodiment. FIG. 5 is a schematic view of a disposable syringe and a catheter in the present embodiment.

  The chemical solution recognition monitoring mechanism 9 in the present embodiment includes a chemical solution recognition electrode 91, a barcode 95 which is a storage unit storing chemical solution information, and the chemical solution information from the barcode 95 before the chemical solution 11a is sprayed. From the reader 96 which is a reading unit for reading the information and the chemical information read by the reader 96, the type of the chemical 11a is discriminated before the chemical 11a is sprayed as in the first embodiment, and the chemical information on the chemical 11a is determined. There is provided a chemical liquid recognition monitoring circuit 93 for setting the optimum applied voltage magnitude and the rotation speed of the motor 61 according to the above. In addition, when the chemical liquid 11a is sprayed, the chemical liquid recognition monitoring circuit 93 always monitors the conductivity or resistance value measured by the chemical liquid recognition electrode 91 as in the first embodiment.

  In the chemical solution information, for example, the type, conductivity, resistance value, current value, and the like of the chemical solution 11a are stored in advance.

  The barcode 95 is provided on the outer peripheral side surface 21a of the disposable syringe 21, for example. The reader 96 is disposed so as to face the barcode 95 when the voltage application electrode 51 and the electrode contact member 42 are connected and the chemical liquid recognition electrode 91 and the chemical liquid recognition electrode contact member 92 are connected in the housing 15b. Yes. The chemical solution information read by the reader 96 is input to the chemical solution recognition monitoring circuit 93.

  For example, similarly to Step 3 shown in FIG. 3 in the first embodiment, when the disposable syringe 21 is arranged in the housing 15b, the chemical liquid information is read by the reader 96 and input to the chemical liquid recognition monitoring circuit 93. Thereby, the type of the chemical solution 11a is discriminated by the chemical solution recognition monitoring circuit 93, and the optimum magnitude of the applied voltage and the rotation speed of the motor 61 according to the chemical solution information of the chemical solution 11a are set by the chemical solution recognition monitoring circuit 93. Since the subsequent operation is the same as that of the first embodiment and the second embodiment described above, detailed description thereof is omitted.

  Thus, the present embodiment can obtain the same effects as those of the first and second embodiments described above. Moreover, this embodiment can determine from the chemical | medical solution information whether the chemical | medical solution 11a should be used before the chemical | medical solution 11a is spray-administered by the chemical | medical solution recognition monitoring circuit 93, and can prevent the administration mistake of the chemical | medical solution 11a. In the present embodiment, the chemical solution recognition monitoring circuit 93 can recognize whether the disposable syringe 21 is disposed in the housing 15b. Thus, in the present embodiment, only when the disposable syringe 21 is arranged in the housing 15b, the voltage application unit 5 and the chemical solution feeding mechanism 6 are operated so as to operate the voltage application unit 5 and the chemical solution feeding mechanism 6. Can be limited.

  In the present embodiment, the storage unit need not be limited to the bar code 95. For example, an optical method, a radio wave method, an electrical method, etc. that can acquire chemical information, such as an IC chip, an RF tag, or a built-in resistance reading. May be used.

  The configuration using the storage unit and the reading unit in the present embodiment is effective when the product is sold in a state in which various types of chemical solutions 11 a are loaded in advance in the disposable syringe 21.

  Further, this embodiment may be used in combination with the first and second embodiments.

  As described above, the present invention is not limited to the above-described embodiments as they are, and can be embodied by modifying the constituent elements without departing from the scope of the invention in the implementation stage. Various inventions can be formed by appropriately combining a plurality of constituent elements disclosed in the above-described embodiments.

FIG. 1 is a schematic view of a liquid spray administration device according to the first embodiment. FIG. 2 is a view showing a disposable syringe and a catheter when a chemical solution is sprayed. FIG. 3 is a flowchart showing the operation of the liquid spray administration device. FIG. 4 is a flowchart showing the operation of the liquid spray administration device in the second embodiment. FIG. 5 is a schematic view of a disposable syringe and a catheter in the third embodiment. FIG. 6 is a view showing an embodiment of a conventional catheter assembly.

Explanation of symbols

  DESCRIPTION OF SYMBOLS 1 ... Liquid spray administration apparatus, 2 ... Chemical liquid filling part, 3 ... Spraying part, 5 ... Voltage application part, 6 ... Chemical liquid feeding mechanism, 9 ... Chemical liquid recognition monitoring mechanism, 11a ... Chemical liquid, 11b ... Chemical liquid fine particle, 12a ... Living body , 12b ... affected part, 19 ... insulating member, 20a ... display part, 20b ... sound generating part, 21 ... disposable syringe, 22 ... piston, 31 ... catheter, 31c ... spray port, 41 ... voltage generating circuit, 42 ... electrode contact member, DESCRIPTION OF SYMBOLS 51 ... Voltage application electrode, 61 ... Motor, 62 ... Control circuit, 63 ... Ball screw, 64 ... Movable part, 91 ... Chemical solution recognition electrode, 92 ... Chemical solution recognition electrode contact member, 93 ... Chemical solution recognition monitoring circuit

Claims (6)

In a liquid spray administration device that is inserted into the body and sprayed and adhered to the desired site in the body,
A liquid filling portion for filling the liquid;
A catheter having a spray port for connecting the liquid filling part at one end and spraying the liquid at the other end;
A liquid recognizing and monitoring mechanism that is disposed near the liquid filling unit or the one end, recognizes the liquid, and monitors proper administration of the liquid;
A voltage application unit that is arranged near the liquid filling unit or near the one end, generates a voltage set by the liquid recognition monitoring mechanism according to the liquid, and applies the voltage to the liquid;
A liquid feeding mechanism for feeding the liquid applied by the voltage application unit to the spray port;
A liquid spray administration device comprising:   The liquid spray administration device according to claim 1, wherein the voltage application unit is caused to stop generating the voltage by the liquid recognition monitoring mechanism according to a monitoring result of the liquid recognition monitoring mechanism.   The liquid recognition monitoring mechanism sets the magnitude of the voltage according to the liquid monitored before the liquid is sprayed, then causes the liquid feeding mechanism to feed the liquid, and causes the voltage application unit to The liquid spray administration device according to claim 1, wherein the voltage is applied to the liquid.   The liquid recognition monitoring mechanism stops the liquid feeding by the liquid feeding mechanism according to the liquid monitored when the liquid is sprayed, and the voltage application unit applies the voltage to the liquid. 2. The liquid spray administration device according to claim 1, wherein the application is stopped.   The liquid spray administration device according to claim 1, wherein the liquid recognition monitoring mechanism monitors proper administration of the liquid by recognizing and monitoring the conductivity or resistance value of the liquid.   The liquid spray administration device according to claim 1, wherein the liquid recognition monitoring mechanism monitors proper administration of the liquid by recognizing and monitoring a current value of the liquid.

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