JP2009007266A - Silver ion water for cosmetic and low-irritant cosmetic using the same - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide new silver ion water for a cosmetic having excellent antibacterial properties, safety and usability and usable for persons with sensitive skin by stopping the formulation of a paraoxybenzoic acid ester having irritancy and to provide the low-irritant cosmetic using the silver ion water. <P>SOLUTION: The silver ion water for the cosmetic is a liquid obtained by formulating a composition prepared by uniformly dispersing silver oxide or a silver ionized substance in a borosilicate-based substance and having antibacterial functions with water and then heating and filtering the resultant formulation. The silver concentration in the liquid is 0.01-100 ppm based on the weight. The low-irritant cosmetic is prepared by formulating the silver ion water with one or two or more kinds such as phenoxyethanol, 1,3-butylene glycol, 1,2-pentanediol, dehydroacetic acid and salts thereof, sorbic acid and salts thereof and salicylic acid and salts thereof etc. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention relates to a highly safe silver ion water for cosmetics containing silver ions and a hypoallergenic cosmetic using the same.

  Conventionally, cosmetics containing water such as lotion, milky lotion, cream and the like usually contain preservatives and antibacterial components. This is because primary contamination contaminated with microorganisms during the preparation and production of cosmetics, as well as secondary contamination contaminated with microorganisms when the consumer opens and closes the container after opening the container, prevents alteration due to the propagation of microorganisms. This is because it is necessary to prevent.

  Examples of antiseptics and antibacterial ingredients used in such cosmetics include phenoxyethanol, paraoxybenzoic acid ester, dehydroacetic acid and its salt, sorbic acid and its salt, salicylic acid and its salt, benzalkonium chloride, alkyltrimethylammonium chloride, etc. Quaternary ammoniums, amphoteric surfactants such as sodium stearylethylbetaine chloride, glycols such as 1,3-butylene glycol and pentylene glycol, and ethanol are conventionally known. Used in combination.

  However, these antibacterial components not only have primary irritation to the skin, but also sensitization that causes irritation by binding to other components, and irritation due to the action of light. It has been a problem because it has photosensitization properties that lead to For this reason, there is a restriction on the amount of cosmetics to be added, but there has been a problem in that it is necessary to increase the amount to be higher than the regulated value in order to sufficiently exert the antibacterial effect.

  In addition, a substance that exhibits a sufficient antibacterial effect with a relatively small amount of blend is generally highly irritating to the skin. On the other hand, glycols with low skin irritation not only exhibit a sufficient antibacterial effect when used alone, but also give a sticky feeling when using cosmetics. It had to be effective. Furthermore, even ethanol that is generally considered to be highly safe cannot be said to have sufficiently low skin irritation because some users have a red rash.

  Therefore, recently, as shown in Patent Document 1, attempts have been made to use naturally-derived components such as buckwheat extract and hinokitiol together with the above synthetic components for the purpose of reducing skin irritation. However, when these natural antibacterial components are blended so as to exhibit a sufficient antibacterial effect, there is a problem that coloring is intense or coloring or an undesired fragrance is generated due to changes over time. In addition, even though it is relatively hypoallergenic, it has a certain degree of skin irritation, which has been a problem when blended in large amounts.

  On the other hand, a silver colloidal solution in which silver is colloidally dispersed is metallic silver that has not been ionized, and since antibacterial properties are effective only in contact with silver, the antibacterial effect is limited. On the other hand, when silver is ionized, the antibacterial effect is exhibited widely.

  In addition, as disclosed in Patent Document 2, antibacterial metal-supported ceramics such as silver antibacterial zeolite has been tried as a highly safe antibacterial component. However, even if the ceramic powder is a fine particle, it gradually settles in the liquid, and even in an emulsified system, reaggregation and precipitation occur due to changes over time. In addition, when separation occurs in this way, sufficient antibacterial properties cannot be obtained.

  Therefore, as shown in Patent Document 3, a method using a water-soluble organic acid has recently been proposed as a method for stably dispersing silver antibacterial zeolite or the like in an aqueous liquid. However, the usage conditions are limited to the acidic pH region, and the presence of a water-soluble organic acid component causes zinc and aluminum to dissolve in the cosmetic. Therefore, these effects as other ionic components in the cosmetic It was necessary to limit to those that did not receive.

Thus, by any conventional method using a silver-based antibacterial material, silver ion water for cosmetics and hypoallergenic cosmetics that are highly safe and transparent and can be used in a wide pH range. The current situation is that it was not possible to obtain.
JP-A-11-222455 JP-A-9-208401 JP 2000-247822 A

  The present invention solves the problems as described above, and can exhibit sufficient antibacterial properties, safety and usability without using conventional irritating paraoxybenzoic acid esters, and has a wide pH range. In addition, the present invention has been completed for the purpose of providing a silver ion water for cosmetics that can be used stably within the range of the composition of ingredients and a hypoallergenic cosmetic using the same.

The present invention made to solve the above problems is obtained by mixing a composition having an antibacterial function in which silver oxide or a silver ionized material is uniformly dispersed in a borosilicate-based material with water, followed by heating and filtration. A silver ion water for cosmetics characterized in that the silver concentration in the liquid is 0.01 to 100 ppm on a weight basis.
In addition, to such cosmetic silver ion water, phenoxyethanol, 1,3-butylene glycol, 1,2-pentanediol, 1,2-alkanediol, 1,2-hexanediol, glycerin mono-2-ethylhexyl ether , Ethylene glycol, propylene glycol, dipropylene glycol, 3-methyl-1,3-butanediol, hexylene glycol, diglycerin, ethanol, polyhydric alcohol alkyl ether, polyaminopropyl biguanide, glyceryl caprylate, dehydroacetic acid and its Salts, sorbic acid and its salts, salicylic acid and its salts, quaternary ammoniums such as benzalkonium chloride and alkyltrimethylammonium chloride, amphoteric surfactants such as sodium stearylethylbetaine chloride, Photosensitive No. 101, Photosensitive 201 No., photosensitive element 4 No. 1, hinokitiol and its derivatives and their salts, rosemary extract, camellia extract, horseradish root extract, kimchi lactic acid bacteria extract, red algae extract, licorice extract, mugwort extract, Chinese mugwort extract, willow bark extract, willow tree extract, chlor Hypoallergenic, characterized in that it contains one or more selected from the group consisting of phenesin, PCA benzyl, citronellate sodium salt, N-long chain acyl basic amino acid derivatives and acid addition salts thereof Cosmetics are the second invention.

  The present invention is a liquid obtained by mixing a composition having an antibacterial function in which silver oxide or a silver ionized substance is uniformly dispersed in a borosilicate-based substance with water, followed by heating and filtration. Since silver ion water for cosmetics having a silver concentration of 0.01 to 100 ppm on a weight basis, it does not contain a stimulating paraoxybenzoic acid ester as in the past, and is sufficiently antibacterial, safe, Silver ion water for cosmetics that is excellent in usability and can be used by people with sensitive skin is obtained. Moreover, silver concentration is 0.01-100 ppm on a weight basis, antibacterial property, safety | security, and usability can be ensured in the range of wide pH and a compounding component composition, and also it will be excellent in storage stability.

  Further, using such silver ion water, one or more of phenoxyethanol, 1,3-butylene glycol, 1,2-pentanediol, dehydroacetic acid and its salt, sorbic acid and its salt, salicylic acid and its salt, etc. By blending two or more types into cosmetics, the antibacterial activity is synergistically improved, preventing deterioration and discoloration over a long period of time, and reducing the amount of preservatives and antibacterial substances added than before. Therefore, it is possible to obtain a hypoallergenic cosmetic material that is extremely low in irritation to the skin.

Below, the preferable form of this invention is demonstrated.
The borosilicate material referred to in the present invention is, for example, borosilicate glass, and a composition having an antibacterial function in which silver oxide or silver ionized material is uniformly dispersed is a so-called antibacterial glass. is there. And in this invention, it is the liquid which has an antibacterial property obtained by heating and filtering this after mix | blending with water, and the silver concentration in a liquid is 0.01-100 ppm on a weight basis in the silver ion water for cosmetics. is there.

  Silver is known as a trace metal that is necessary in the body and has a function of enhancing immunity, and is also known to be a metal with strong bactericidal activity. According to the study of the present inventor, silver is a metal having a strong bactericidal power, but when silver ionized water is blended in cosmetics, even when blended at a high concentration, there is surprisingly no irritation to the skin. In addition, it was confirmed that even at a considerably low concentration, sufficient antibacterial activity was exhibited.

Here, the silver ion water is one in which silver particles are dispersed and dissolved in water or a water-containing aqueous solution, and this is a transparent to light yellowish brown liquid. And the following methods can be used for manufacture of silver ion water.
A composition having an antibacterial function in which silver oxide and a silver ionized material are uniformly dispersed in a borosilicate-based material is mixed with water, and the solution is heated and filtered to maintain a stable silver ionized liquid state. In addition to the borosilicate material, an antibacterial composition in which silver oxide and silver ions are uniformly dispersed in a phosphate material may be used. It can also be produced by electrolyzing silver.
However, with silver ion water produced by electrolyzing silver, discoloration, etc. is observed when blended into the formulation, but use borosilicate based material in which silver oxide and silver ionized material are uniformly dispersed It was found that the discolored silver ion water can suppress discoloration of the preparation.

  Moreover, as for the silver ion water obtained by said manufacturing method, the density | concentration of the silver in an aqueous medium is 0.01-100 ppm on a weight basis. This is because when the concentration is lower than 0.1 ppm, it is difficult to obtain an antibacterial effect, while when the concentration is higher than 100 ppm, the production becomes difficult and the stability may be impaired. Most preferably, it is in the range of 0.1 to 10 ppm.

  In silver ion water for cosmetics as described above, phenoxyethanol, 1,3-butylene glycol, 1,2-pentanediol, 1,2-alkanediol, 1,2-hexanediol, glycerin mono-2-ethylhexyl ether, Ethylene glycol, propylene glycol, dipropylene glycol, 3-methyl-1,3-butanediol, hexylene glycol, diglycerin, ethanol, polyhydric alcohol alkyl ether, polyaminopropyl biguanide, glyceryl caprylate, dehydroacetic acid and its salts Sorbic acid and its salts, salicylic acid and its salts, quaternary ammoniums such as benzalkonium chloride and alkyltrimethylammonium chloride, amphoteric surfactants such as sodium stearylethylbetaine chloride, Photosensitive No. 101, Photosensitive No. 201 , Photosensitive element 401 , Hinokitiol and its derivatives and their salts, rosemary extract, camellia extract, horseradish root extract, kimchi lactic acid bacteria extract, red algae extract, licorice extract, mugwort extract, Chinese mugwort extract, willow bark extract, willow tree extract, chlorphenesin , PCA benzyl, citronellate sodium salt, N-long chain acyl basic amino acid derivative, and one or more selected from the group consisting of acid addition salts thereof to make hypoallergenic cosmetics You can also.

  Here, cosmetics are skin care cosmetics such as lotion, milky lotion, cream, cosmetic liquid, pack, sheet-like pack, makeup cosmetics such as liquid foundation, skin cleansing such as cleansing cream, face wash, soap, body shampoo, etc. Deodorant cosmetics such as shampoos, antiperspirants and deodorants, and hair cosmetics such as shampoos, rinses, treatments and hair stylings.

  The cosmetics thus obtained do not use conventional irritating paraoxybenzoic acid esters, so they are hypoallergenic and gentle to the skin, and have sufficient antibacterial properties, safety and usability. In addition, it can be used stably in a wide range of pH and blending component composition.

  Here, the blending ratio of silver ion water is 0.1 to 100% based on the weight of the entire cosmetic. Mixing ratio. If it is 0.1% or less, the antibacterial effect is insufficient. On the other hand, since there is no skin irritation, the silver ion water obtained by the above production method can be applied to the skin as it is in a state of 100%. That is, since there is no problem such as irritation to the skin, it can be blended at an arbitrary high concentration, thereby realizing a highly safe sterilization method. For the purpose of antibacterial property alone, a blending ratio of 20% or less is sufficient.

Furthermore, the cosmetics of the present invention include silver ion water and specific antibacterial agents, oily ingredients, surfactants, moisturizers, pigments, ultraviolet absorbers, antioxidants, fragrances and other general pharmaceuticals and quasi drugs. Products, cosmetic raw materials, cell activators, anti-inflammatory agents, whitening agents, and the like.
In addition, it is also possible to dilute silver ion water and use it as daily miscellaneous goods, such as disinfection, antibacterial, and deodorant.

Examples of the present invention will be described below.
Tables 1 to 5 show glycerin aqueous solution as a typical lotion, the case of using the antibacterial component of the present invention as Examples 1 to 7, and the case of using the conventional antibacterial component as Comparative Examples 1 to 15 and the test results. Show.
In addition, as an antibacterial component of this invention, it was the silver ion water obtained by the said manufacturing method, Comprising: The ionized liquid whose silver concentration is 3-4 ppm in the pure water was used. Specifically, “Ag-P water (manufactured by Shinei Chemical Co., Ltd.)” was used. Moreover, in Example 4 shown in Table 1, silver ion water was used as it was, without mix | blending glycerol.
The lotion solution for evaluation test (glycerin aqueous solution) was stirred so that 1.0 part by weight of glycerin, a predetermined part by weight of the antibacterial component shown in these tables, and purified water totaled 100 parts by weight. While mixing.
In Comparative Examples 5 to 7 using hinokitiol as an antibacterial component, purified water was added after hinokitiol was heated and dissolved in glycerin.

The evaluation method is as follows.
(1) State After storage for 1 month in a 45 ° C. thermostatic bath under a sealed cap, the presence or absence of precipitation or coloring was observed.
(2) Irritability (red spot) and discomfort after use Using 48 male and female panelists, a 48-hour closed patch test is conducted, and the evaluation criteria shown in the upper part of Table 6 are evaluated, and an arithmetic average is obtained. It was used as an index of direct skin irritation. Moreover, after this closure sticking test, based on the sensory evaluation by these panelists, it evaluated by the criteria shown in the lower part of Table 6, and the arithmetic average was calculated | required and it was set as the discomfort index after use.
(3) Antimicrobial Escherichia coli (E, coli), Staphylococcus aureus (S, aureus), using a mixed bacteria Pseudomonas aeruginosa (P, aeruginosa), 10 ^six, was inoculated into the liquid for evaluation testing Cultured at 37 ° C. The number of viable bacteria after 7 days was measured, and the number of bacteria that had reached zero by this time was marked as ◯, and the number that did not become zero was marked as x.

  As shown in Table 1, with the lotion liquids of the examples, skin irritation and discomfort after use are extremely low, and it is considered that there is almost no influence of silver ion water as an antibacterial component. In addition, the liquid properties and storage stability are good, and the antibacterial properties are also excellent. In particular, sufficient antibacterial properties were obtained even in Example 1 in which the silver ionized lotion solution contained only 0.16 ppm of silver and silver ions.

  As shown in Comparative Examples 1 to 4 in Table 2, when an organic synthetic antibacterial component was used, a sufficient antibacterial property could not be obtained with a blending amount of 0.1 wt%, and 0.3 wt% or 0.5 wt%. Sufficient antibacterial activity was obtained only when blended in weight percent. However, with such a formulation, skin irritation was remarkable and discomfort after use became significant. Further, depending on the type of antibacterial component, discoloration or the like was observed when the concentration was high enough to exhibit sufficient antibacterial activity. On the other hand, Example 5 was low in irritation, excellent in usability, and sufficiently antibacterial.

As shown in Comparative Examples 5 to 10 in Table 3, even when natural antibacterial agents were used, skin irritation and discomfort after use clearly appeared when the concentration to be blended was increased. However, it was considerably lower than that of synthetic antibacterial agents.
In addition, no formulation example was found that could provide sufficient performance for storage stability, liquid properties, and antibacterial activity.

  As shown in Comparative Examples 11 to 13 in Table 4, when 0.5 to 2.0% by weight using a silver-supporting zeolite was blended, the antibacterial property was sufficient and the skin irritation was low. However, the discomfort after use was remarkably stronger than that of the example using silver ion water, especially when blended at a high concentration. Moreover, since separation and precipitation occurred, the properties and storage stability of the lotion solution were remarkably inferior.

  As shown in Table 5, Comparative Examples 14 and 15 were inferior in antibacterial properties, but the creams of Examples 6 and 7 had extremely low skin irritation and unpleasant feeling after use when used in combination with silver ion water. The emulsion had sufficient antibacterial properties and good emulsification properties and storage stability.

Claims (2)

  A liquid obtained by mixing a composition having an antibacterial function in which silver oxide or a silver ionized substance is uniformly dispersed in a borosilicate-based material with water, followed by heating and filtration, and the silver concentration in the liquid is weight. Silver ion water for cosmetics characterized by being 0.01 to 100 ppm in base.   The silver ion water for cosmetics according to claim 1 is added to phenoxyethanol, 1,3-butylene glycol, 1,2-pentanediol, 1,2-alkanediol, 1,2-hexanediol, glycerin mono-2-ethylhexyl. Ether, ethylene glycol, propylene glycol, dipropylene glycol, 3-methyl-1,3-butanediol, hexylene glycol, diglycerin, ethanol, polyhydric alcohol alkyl ether, polyaminopropyl biguanide, glyceryl caprylate, dehydroacetic acid and Salts thereof, sorbic acid and salts thereof, salicylic acid and salts thereof, quaternary ammoniums such as benzalkonium chloride and alkyltrimethylammonium chloride, amphoteric surfactants such as sodium stearylethylbetaine chloride, photosensitizer No. 101, photosensitizer No. 201, Photosensitive Element 4 No. 1, hinokitiol and its derivatives and their salts, rosemary extract, camellia extract, horseradish root extract, kimchi lactic acid bacteria extract, red algae extract, licorice extract, mugwort extract, Chinese mugwort extract, willow bark extract, willow tree extract, chlor Hypoallergenic, characterized in that it contains one or more selected from the group consisting of phenesin, PCA benzyl, citronellate sodium salt, N-long chain acyl basic amino acid derivatives and acid addition salts thereof Cosmetics.