JP2007292718A - Multi-item test paper and method for detecting test material in specimen - Google Patents
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Abstract
Description
本発明は検査結果を目視により、又は装置を用いて判定する多項目試験紙および検体中の被検物質の検出方法に関するものである。 The present invention relates to a multi-item test paper for judging a test result visually or using an apparatus, and a method for detecting a test substance in a sample.
尿や血液中の被検物質の検査は、医療における臨床検査として疾病の予防や診断に不可欠である。この検査方法としては、採尿や採血を行い、その中の被検物質の存在を確認したり、定量するものが挙げられる。
しかしながら、この方法は操作が煩雑で、しかも病院などの特定の場所でないと検査を行うことができないばかりでなく、分析に時間がかかるなどの問題がある。
Testing of test substances in urine and blood is indispensable for disease prevention and diagnosis as a clinical test in medicine. Examples of this test method include a method in which urine collection or blood collection is performed, and the presence of a test substance in the sample is confirmed or quantified.
However, this method has a problem that the operation is complicated and the inspection can be performed only at a specific place such as a hospital, and the analysis takes time.
このため、臨床検査における、尿検査に代表される各種液体試料の初期診断情報としてのスクリーニングや集団検診として、乾式の試験紙を用いて検査を行う、所謂ディップ・アンド・リード方式が数多く提案されている（例えば、特許文献１、２、３、４、５、６、７および８参照）。
For this reason, many so-called dip-and-read methods have been proposed in which tests are performed using dry test papers as screening for initial diagnosis information of various liquid samples typified by urinalysis and mass screening in clinical tests. (For example, see
このディップ・アンド・リード方式とは、コップに入れた検体に試験紙を浸した後に引き上げて、試験紙上の検出部位の呈色応答を目視により、又は光学装置で読み取る判定方式をいう。目視の場合は、予め別に用意されている標準色調表と試験紙の呈色とを対比することにより判定し、光学装置の場合は、予め組み込まれた検量線に当てはめて呈色強度を分析して判定する。 The dip-and-read method is a determination method in which a test paper is dipped in a sample placed in a cup and then pulled up, and the color response of a detection site on the test paper is read visually or with an optical device. In the case of visual observation, judgment is made by comparing the standard color chart prepared separately in advance with the color of the test paper, and in the case of an optical device, the color intensity is analyzed by applying it to a pre-installed calibration curve. Judgment.
使用される試験紙の外観は、プラスチック又は紙の支持体上に、分析対象に対応した各種の試薬を含浸させた濾紙などを方形に裁断した検出部位を１又は２以上設置したものが一般的である。 The appearance of the test paper used is generally a plastic or paper support with one or two or more detection sites cut into squares of filter paper impregnated with various reagents corresponding to the analysis target. It is.
この検出部位には、それぞれ異なる検査項目に対応する試薬が乾燥状態で仕込まれており、液体試料中の被検物質との反応により呈色反応といった目視又は光学装置で判断可能な応答を示す。
この種の検査は、測定項目の数も増加しており、現在では１つの試験紙で１０項目以上の検査ができる多項目試験紙も実用化されている（例えば、特許文献９参照）。
In this detection site, reagents corresponding to different test items are charged in a dry state, and show a response that can be judged visually or by an optical device such as a color reaction by reaction with a test substance in a liquid sample.
In this type of inspection, the number of measurement items has increased, and at present, a multi-item test paper capable of inspecting 10 items or more with one test paper has been put into practical use (see, for example, Patent Document 9).
しかしながら、従来の試験紙は、１本の支持体に１検体分の試薬部が設けられているに過ぎず、多検体を処理するには、多大な時間を要すると共に、試験紙を収納するボトルのスペースも広いものが必要であるという問題があった。 However, the conventional test paper is only provided with a reagent portion for one sample on one support, and it takes a lot of time to process multiple samples, and a bottle for storing the test paper. There was a problem that a large space was required.
一方、１本の支持体に１検体分の検出部位を多数連設した多項目試験紙が提案されている（例えば、特許文献１０参照）。
しかしながら、この多項目試験紙は、１検体分の検出部位が多数連設されているため、光学装置専用の滴下型しか使用できず、ディップ・アンド・リード方式に適さないという問題があった。
On the other hand, a multi-item test paper has been proposed in which a large number of detection sites for one specimen are connected to a single support (see, for example, Patent Document 10).
However, since this multi-item test paper has a large number of detection sites for one sample, only the dropping type dedicated to the optical device can be used, and there is a problem that it is not suitable for the dip-and-read method.
従って本発明は、１本の支持体に２検体分の試薬部を設けることにより、光学装置を用いた滴下方式に適するばかりでなく、目視によるディップ・アンド・リード方式にも適用することができる多項目試験紙および検体中の被検物質の検出方法を提供することを目的とする。
また、本発明は、１検体分の試薬部を設けた従来の試験紙に比べて、検体処理能力を大幅に向上させることができ、更に同じスペースでも２倍の検査用試薬部を保持する試験紙を収納することができる多項目試験紙および検体中の被検物質の検出方法を提供することを目的とする。
Therefore, the present invention can be applied not only to a dropping method using an optical device but also to a visual dip-and-read method by providing a reagent portion for two specimens on one support. An object of the present invention is to provide a method for detecting a test substance in a multi-item test paper and a specimen.
In addition, the present invention can greatly improve the sample processing capacity compared with the conventional test paper provided with a reagent portion for one sample, and further retains twice the test reagent portion in the same space. An object of the present invention is to provide a multi-item test paper capable of storing paper and a method for detecting a test substance in a specimen.
本発明者は、１本の支持体に２検体分の試薬部を設けることによって上記従来の課題を解決できることを見出し、本発明を完成させた。 The present inventor has found that the conventional problems can be solved by providing a reagent portion for two specimens on one support, and has completed the present invention.
本発明は、下記のような構成からなるものである。
（１）検体中の被検物質と反応して発色する検査用試薬部を支持体の一端部に設け、更に前記検査用試薬部と同一の検査用試薬部を前記支持体の他端部に設けることを特徴とする多項目試験紙。
（２）検査用試薬部を支持体の中間部に設ける（１）記載の多項目試験紙。
（３）検体中の被検物質と反応して発色する検査用試薬部を支持体上に設け、更に前記検査用試薬部と同一の検査用試薬部を前記検査用試薬部に対して連続的に設けることを特徴とする多項目試験紙。
（４）検体が尿、血液、血漿、血清、唾液、髄液および喀痰から選ばれる（１）〜（３）記載の多項目試験紙。
（５）支持体の一端部に設けた検査用試薬部における発色の度合を自動検査装置を用いて光学的に検出し、更に支持体の他端部に設けた前記検査用試薬部と同一の検査用試薬部における発色の度合を光学的に検出することを特徴とする検体中の被検物質の検出方法。
（６）検査用試薬部を支持体の中間部に設ける（５）記載の検体中の被検物質の検出方法。
（７）支持体上に設けた検査用試薬部と同一の検査用試薬部を前記検査用試薬部に対して連続的に設ける（５）記載の検体中の被検物質の検出方法。
（８）検出手段が反射率計およびＣＣＤセンサーから選ばれる（５）〜（７）記載の検体中の被検物質の検出方法。
The present invention has the following configuration.
(1) A test reagent part that reacts with a test substance in a sample to develop a color is provided at one end of the support, and the same test reagent part as the test reagent is provided at the other end of the support. Multi-item test paper characterized by being provided.
(2) The multi-item test paper according to (1), wherein a test reagent part is provided in an intermediate part of the support.
(3) A test reagent part that reacts with a test substance in the sample to develop a color is provided on the support, and the same test reagent part as the test reagent part is continuously provided with respect to the test reagent part. Multi-item test paper, characterized in that it is provided.
(4) The multi-item test paper according to (1) to (3), wherein the specimen is selected from urine, blood, plasma, serum, saliva, spinal fluid and sputum.
(5) The degree of color development in the test reagent portion provided at one end of the support is optically detected using an automatic inspection device, and the same as the test reagent portion provided at the other end of the support A method for detecting a test substance in a specimen, which optically detects the degree of color development in a test reagent part.
(6) The method for detecting a test substance in a specimen according to (5), wherein a test reagent part is provided in an intermediate part of the support.
(7) The method for detecting a test substance in a specimen according to (5), wherein the same test reagent part as the test reagent part provided on the support is continuously provided for the test reagent part.
(8) The method for detecting a test substance in a specimen according to (5) to (7), wherein the detection means is selected from a reflectometer and a CCD sensor.
本発明の方法によれば、１本の支持体に２検体分の試薬部を設けることによって、光学装置を用いた滴下方式に適するばかりでなく、目視によるディップ・アンド・リード方式にも適し、更に多検体を短時間で処理できると共に、同じスペースでも２倍の検査用試薬部を保持する試験紙を収納することができる。
以下、本発明について更に詳細に説明する。
According to the method of the present invention, by providing a reagent portion for two specimens on one support, it is suitable not only for a dropping method using an optical device but also for a visual dip-and-read method, Furthermore, it is possible to process a large number of specimens in a short time, and it is possible to store a test paper holding a double test reagent part in the same space.
Hereinafter, the present invention will be described in more detail.
図１、図２および図３は本発明に係る多項目試験紙の一実施例を示す平面図である。図１〜図３において、１は多項目試験紙、２は支持体、３〜５は検査用試薬部を示す。 1, 2 and 3 are plan views showing an embodiment of a multi-item test paper according to the present invention. 1 to 3, 1 is a multi-item test paper, 2 is a support, and 3 to 5 are test reagent parts.
本発明においては、３〜５の検査用試薬部を支持体２の一端部とは別に、支持体２の他端部（図１参照）、中間部（図２参照）または前記検査用試薬部と連続的（図３参照）に設けたことが最も特徴がある点である。このように本発明では、支持体２に２検体を設けた形態とすることで、自動検査装置が多項目試験紙１をピックアップする時間を短縮することができるので、時間あたりの処理能力を大幅に向上させることができる。
また、従来は試験紙ボトル１００枚で１００検体分であったため、２００検体分を自動検査装置にセットする場合、２ボトル分のスペースが必要であったが、本発明においては、支持体２に２検体分を設けることによって同じスペースでも２倍の検査用試薬部を保持する試験紙を収納することができる。
In the present invention, 3 to 5 test reagent parts are separated from one end part of the
Conventionally, since 100 test paper bottles are for 100 samples, when 200 samples are set in the automatic inspection apparatus, a space for 2 bottles is required. By providing two samples, it is possible to store a test paper that holds twice the test reagent part in the same space.
本発明に適用できる検体としては、特に限定されないが、例えば、尿、血液、血漿、血清、唾液、髄液および喀痰などから選ばれるものが挙げられる。検査用試薬部３〜５で検出できる検体中の被検物質としては、例えば、蛋白質、尿素、クレアチニン、アンモニア、尿酸、ビリルビン、潜血、ウロビリノーゲン、ケトン体、白血球、亜硝酸塩、比重、ｐＨ、ブドウ糖、乳酸、コレステロールなどが挙げられる。
The sample applicable to the present invention is not particularly limited, and examples thereof include those selected from urine, blood, plasma, serum, saliva, spinal fluid, sputum and the like. Examples of the test substance in the specimen that can be detected by the
検査用試薬部３〜５は、支持体２に検査試薬を保持させて形成されるが、支持体２としては検査試薬を保持し得るものであれば、特に限定されるものではなく、公知のものの中から適宜選択すれば良い。具体的には、例えば上質紙、コート紙、アート紙などの紙類、ポリスチレン、ポリエチレン、ポリ塩化ビニル、ポリプロピレンなどの合成樹脂をベースとした合成紙が挙げられる。
The
本発明の多項目試験紙を構成する検査用試薬部３〜５に、点着、滴下、又は浸漬により含浸された検体中の被検物質は、検査用試薬部中の試薬と反応して反応体を生成する。この反応体を、目視によって検出しても良いが、好ましくは反射率計およびＣＣＤセンサーから選択されるもので検出する。
The test substance in the specimen impregnated by spotting, dropping, or dipping in the
本発明は、１本の支持体に２検体を設けた形態とすることで、自動検査装置の処理時間を大幅に短縮することができると共に、２ボトル分必要であった試験紙ボトルのスペースが１ボトル分で足り、省スペース化を実現することができる多項目試験紙および検体中の被検物質の検出方法を提供するものである。 In the present invention, by providing two specimens on one support, the processing time of the automatic inspection apparatus can be greatly shortened, and the space for the test paper bottle required for two bottles can be reduced. It is an object of the present invention to provide a multi-item test paper and a method for detecting a test substance in a specimen that can be saved in space because one bottle is sufficient.
１ 多項目試験紙
２ 支持体
３〜５ 検査用試薬部
1 Multi-item test strip
2 Support 3-5 Reagents for testing
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015141201A (en) * | 2014-01-29 | 2015-08-03 | 立創生医科技股▲ふん▼有限公司 | Quantified output system of physiological parameter |
| CN105334211A (en) * | 2015-10-20 | 2016-02-17 | 北京中生金域诊断技术股份有限公司 | Kit simultaneously detecting sodium and creatinine in urine |
| CN105388146A (en) * | 2015-10-20 | 2016-03-09 | 北京中生金域诊断技术股份有限公司 | Kit for simultaneously detecting sodium, creatinine and microalbumin in urine |
| KR101773418B1 (en) * | 2015-07-31 | 2017-08-31 | 주식회사 코아리버 | Self-diagnostic test paper for blood sugar and self-diagnostic method for blood using the same |
| CN111983235A (en) * | 2020-07-15 | 2020-11-24 | 湖北金鉴生物有限公司 | Test paper for quantitatively determining urea and preparation method thereof |
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| JPH1164322A (en) * | 1997-08-22 | 1999-03-05 | Toshiba Corp | Analyzing apparatus and test paper for analysis |
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| JPS6392256A (en) * | 1986-10-06 | 1988-04-22 | Nec Corp | Manufacture of primary core of linear pulse motor |
| JPS6460A (en) * | 1987-02-17 | 1989-01-05 | Sumitomo Chem Co Ltd | Benzoylurea derivative, production thereof, insecticide and acaricide comprising said derivative as active ingredient |
| JPH1164322A (en) * | 1997-08-22 | 1999-03-05 | Toshiba Corp | Analyzing apparatus and test paper for analysis |
| WO2006038028A1 (en) * | 2004-10-08 | 2006-04-13 | Honeywell Analytics Ag | Gas detection system |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015141201A (en) * | 2014-01-29 | 2015-08-03 | 立創生医科技股▲ふん▼有限公司 | Quantified output system of physiological parameter |
| KR101773418B1 (en) * | 2015-07-31 | 2017-08-31 | 주식회사 코아리버 | Self-diagnostic test paper for blood sugar and self-diagnostic method for blood using the same |
| CN105334211A (en) * | 2015-10-20 | 2016-02-17 | 北京中生金域诊断技术股份有限公司 | Kit simultaneously detecting sodium and creatinine in urine |
| CN105388146A (en) * | 2015-10-20 | 2016-03-09 | 北京中生金域诊断技术股份有限公司 | Kit for simultaneously detecting sodium, creatinine and microalbumin in urine |
| CN111983235A (en) * | 2020-07-15 | 2020-11-24 | 湖北金鉴生物有限公司 | Test paper for quantitatively determining urea and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| JP4864615B2 (en) | 2012-02-01 |
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