JP2007135814A - Dosing method of drug ion and pin type iontophoresis device - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a pin type iontophoresis device allowing a drug solution to be given from membrane mucosa inside of the pierced hole. <P>SOLUTION: The pin type iontophoresis device 10 is comprised of an acting side electrode structure 12 and non-acting side electrode structure 14 which clip an ear lobe 20 from both sides. The acting side electrode structure 12 has at least a medical solution storing member 28 to store drug ion and the first ion selective membrane 30 contacting with skin, and the first ion selective membrane 30 at the tip of the acting side electrode structure 12 has the center part which forms a projection 48 thin enough to be inserted into the pierced hole 21 with the drug solution storing member 28. By inserting the projection 48 into the pierced hole 21, the drug solution can be given from the inner periphery of the pierced hole 21. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a method for administering drug ions to a living body by iontophoresis and a pin-type iontophoresis device used therefor.

  The iontophoresis device as described above allows drug ions to permeate into the skin and mucous membrane, and conventionally targets skin and mucous membrane of a relatively wide area having a diameter of about 20 mm even when it is small.

  This iontophoresis device has, for example, a working electrode structure and a non-working electrode structure as described in Patent Document 1, and these are connected to a DC power source with different polarities, An ion exchange membrane or the like that is in contact with the skin or mucous membrane is disposed at the tip of each of the working electrode structure and the non-working electrode structure.

  Since the skin secretes sebum and sweat, it may be difficult to bring the ion exchange membranes at the tips of the working electrode structure and the non-working electrode structure into close contact with each other, and the barrier voltage during drug administration is high. As a result, the efficiency of the battery (DC power supply) is reduced.

  On the other hand, when drug ions are administered from the mucosa, the patient or doctor presses them down or has a special adhesive in order to bring the ion exchange membranes at the tips of the working electrode structure and non-working electrode structure into close contact with the mucosa. There is a problem that it is necessary to make a close contact with an agent, the usability is bad, and the burden on the user is large.

WO03 / 037425A1

  An object of the present invention is to provide a drug ion administration method and a pin-type iontophoresis device that do not have a high barrier voltage during drug administration, are easy to handle, and have a low burden on the user.

  As a result of diligent research, the inventor has found that the inner peripheral surface of a hole artificially formed in a living body, such as a piercing hole, has a lower barrier voltage than the outer skin, increases the efficiency of the battery, and burdens the user. The method of administering drug ions by iontophoresis from the inner peripheral surface of the hole and a pin type iontophoresis device used therefor were considered.

  That is, the following problems can be solved by the following embodiments.

  (1) A drug ion administration method comprising artificially forming a hole in a living body and administering the drug ion by iontophoresis from an inner peripheral surface of the hole.

  (2) The living body is a mammal, a pierced hole is formed in the earlobe of the mammal, and drug ions are administered from the inner peripheral surface of the pierced hole by iontophoresis (1) The method for administering drug ions according to 1.

  (3) Working electrode structures and non-working electrode structures used to administer drug ions by iontophoresis, and these working electrode structures and non-working electrode structures have different polarities. A DC power source to be connected, and the working electrode structure is electrically connected to the working electrode connected to the same polarity as the drug ions in the DC power source, A drug solution holding unit for holding the drug ions; and a first ion selective membrane which is disposed in front of the drug solution holding unit and selectively allows the same kind of ions as the drug ions to pass therethrough. At least a part of the functional membrane and the chemical solution holding part is a pin-shaped projection part having a thickness that can be inserted into a hole formed in the living body, and the chemical solution holding part is formed from the first ion selective membrane of the projection part. Administration of chemicals is possible Pin-type iontophoresis device characterized in that it is a.

  (4) The pin-type iontophoresis device according to (3), wherein a pair of the working side electrode structures are provided so that the protrusions face each other.

  (5) The working-side electrode structure and the non-working-side electrode structure are arranged so that their tips are opposed to each other, and the non-working-side electrode structure has a non-working portion facing the projection. The pin-type iontophoresis device according to (3), comprising an ion-selective membrane as a conducting part.

  (6) The non-working side electrode structure is made of an insulator at a position facing the projecting part of the working side electrode structure at a tip thereof, and has a pin-shaped opposing projecting part having substantially the same diameter as the projecting part. The pin-type iontophoresis device according to (5), characterized by comprising:

  (7) The non-working side electrode structure is electrically connected to the non-working side electrode connected to the polarity opposite to the charged ion of the drug ion in the DC power source, and the non-working side electrode In addition, an electrolyte solution holding unit that holds the electrolyte solution, and an ion selective membrane on the non-working side that is disposed on the front surface of the electrolyte solution holding unit and selectively passes ions opposite to the charged ions of the drug ions, And at least one of the non-working side ion-selective membrane and the electrolyte solution holding part is a non-working side projection having a thickness that can be inserted into a piercing hole, and the working-side electrode structure The body and the non-working side electrode structure are arranged so that the protrusions at the tip and the non-working side protrusions are mutually offset in a direction perpendicular to the central axis of these protrusions. Pin type according to (3), characterized in that Onto Foret over cis apparatus.

  (8) The present invention has a clamping device that supports the working electrode structure and the non-working electrode structure so as to be biased or clampable in a direction in which the distal ends approach each other. The pin type iontophoresis device according to any one of the above.

  (9) The protrusion in the working electrode structure is configured by laminating at least the chemical solution holding portion and the first ion selective membrane in this order on the outer periphery of the thin rod-shaped working electrode. The pin-type iontophoresis device according to any one of (3) to (8), wherein

  (10) The working electrode structure is disposed on the working electrode, on the front surface of the working electrode, on the front surface of the electrolytic solution holding section, and on the front surface of the electrolytic solution holding section. A second ion-selective membrane for selectively passing ions opposite to the drug ions; the drug solution holding portion disposed on the front surface of the second ion selective membrane; A non-active side electrode structure connected to a polarity opposite to that of the drug ion in the DC power source, and the non-active side electrode. A second electrolyte solution holding unit that holds the second electrolyte solution and a third ion that is arranged on the front surface of the second electrolyte solution holding unit and selectively passes ions of the same kind as the drug ions Selective membrane and placed in front of this third ion selective membrane A third electrolytic solution holding unit for holding the third electrolytic solution, and a non-working side that is arranged on the front surface of the third electrolytic solution holding unit and selectively passes ions opposite to the charged ions of the ionic drug The pin-type iontophoresis device according to any one of (3) to (9), comprising a fourth ion-selective membrane that is an ion-selective membrane.

  In this invention, at least a part of the first ion-selective membrane and the drug solution holding part at the tip of the working electrode structure is a small-diameter pin-shaped protrusion, from which a drug solution can be administered. When the tip of the projection is inserted into the pierced hole formed in the earlobe, the efficiency of the battery is reduced from the projection through the inner peripheral surface of the pierced hole with a low barrier voltage, and without the user's efficiency. Drug ions can be administered with little burden.

  A pin-type iontophoresis device according to the best mode for carrying out the present invention has a working electrode structure and a non-working electrode structure, and the first ion selectivity at the tip of the working electrode structure. At least a part of the membrane and the chemical solution holding part is a pin-shaped projection having an outer diameter of 0.8 mm to 1.6 mm, and the chemical solution of the chemical solution holding unit is transferred from the first ion selective membrane of the projection. The non-working side electrode structure has a tip that faces the projection in the working side electrode structure, and the fourth ion-selective membrane at the tip faces the projection. The portion is covered with an insulating film so as not to contact the protrusion. For example, when used for the earlobe piercing hole, the protrusion is inserted from one of the piercing holes, and the fourth ion selective membrane of the non-working side electrode structure is inserted into the earlobe from the opposite side of the protrusion and from the outside of the piercing hole. It is comprised so that it may contact.

  Next, a pin type iontophoresis device 10 according to Embodiment 1 of the present invention shown in FIGS. 1 and 2 will be described.

  This pin-type iontophoresis device 10 has a working electrode structure 12 and a non-working electrode structure 14 used to administer drug ions, and a DC power source 16 to which they are connected with different polarities. Configured.

  The working electrode structure 12 and the non-working electrode structure 14 are attached to the tightening device 18 so that the tips of the working electrode structure 12 and the non-working electrode structure 14 face each other so that the earlobe 20 can be sandwiched, for example. As in the case of a normal earring, the tightening device 18 is configured so that the earlobe 20 can be sandwiched between them by the elasticity of a spring or by screwing the working electrode structure 12.

  The working electrode structure 12 includes a working electrode 22, an electrolyte holding unit 24, a second ion selective membrane 26, a chemical solution holding unit 28, and a first ion selective membrane 30 from the base end side. Are stacked in this order to form a substantially disk shape.

  The working electrode 22 is preferably composed of a conductive paint applied to one surface of the base sheet 32 and blended with a nonmetallic conductive filler such as carbon paste. Although this working side electrode 22 can also be comprised with a copper plate or a metal thin film, since the metal eluted from this can transfer to a biological body at the time of a chemical | medical agent coating, non-metal-made is preferable.

  The electrolyte solution holding unit 24 includes an electrolyte, and the electrolyte is more easily oxidized or reduced than water electrolysis (oxidation at the positive electrode and reduction at the negative electrode), such as ascorbic acid (vitamin C) or the like. It is particularly preferable to use a pharmaceutical agent such as sodium ascorbate, an organic acid such as lactic acid, oxalic acid, malic acid, succinic acid, fumaric acid and / or a salt thereof, thereby suppressing generation of oxygen gas and hydrogen gas. In addition, by blending a plurality of types of electrolytes that are combined into a buffer electrolyte when dissolved in a solvent, fluctuations in pH during energization can be suppressed.

  The electrolyte holding unit 24 is a carrier made of any material having water retention, such as a fiber sheet such as gauze or filter paper, or a polymer gel sheet such as a hydrogel of acrylic resin (acrylic hydrogel) or a segmented polyurethane gel. Is impregnated with or contained in an electrolyte solution. Moreover, what hold | maintains electrolyte solution in a liquid state may be used, and electrolyte paint may be used.

  The second ion-selective membrane 26 contains an ion exchange resin into which an ion exchange group having a counter-ion ion having a conductivity type opposite to the drug ion in the drug solution holding unit 28, which will be described later, is introduced. The second ion-selective membrane 26 is blended with an anion exchange resin when a drug that dissociates into drug ions whose pharmacological components in the drug solution holding unit 28 become cations is used. When a drug that dissociates into drug ions is used, a cation exchange resin is blended.

  The drug solution holding unit 28 contains a drug (including a drug precursor) in which a drug component is dissociated into a cation or an anion (drug ion) by being dissolved in a solvent such as water. Examples of drugs that dissociate medicinal components into cations include lidocaine hydrochloride, which is an anesthetic, morphine hydrochloride, which is an anesthetic, and drugs that dissociate medicinal components into anions include vitamins such as ascorbic acid Can be illustrated.

  The chemical solution holding unit 28 electrolyzes a carrier made of any material having water retention properties such as a fiber sheet such as gauze or filter paper, or a polymer gel sheet such as a hydrogel of acrylic resin (acrylic hydrogel) or a segmented polyurethane gel. The liquid is impregnated or contained. Moreover, what hold | maintains electrolyte solution in a liquid state may be sufficient, and what apply | coated the medicine as a coating material may be used.

  The first ion selective membrane 30 contains an ion exchange resin into which an ion exchange group having counter ions of the same conductivity type as the drug ions in the drug solution holding unit 28 is introduced. The first ion-selective membrane 30 is blended with an anion exchange resin or a cation exchange resin when a drug that dissociates into a cation or anion drug ion is used as the medicinal component of the drug solution holding unit 28. The

  Examples of the cation exchange resin include polymers having a three-dimensional network structure such as hydrocarbon resins such as polystyrene resins and acrylic resins, and fluorine resins having a perfluorocarbon skeleton, sulfonic acid groups, and carboxylic acids. An ion exchange resin into which a cation exchange group such as a group or a phosphonic acid group (an exchange group in which the counter ion is a cation) is introduced can be used without limitation.

  The anion exchange resin includes a polymer having the same three-dimensional network structure as the cation exchange resin, a primary to tertiary amino group, a quaternary ammonium group, a pyridyl group, an imidazole group, a quaternary group. An ion exchange resin into which an anion exchange group such as a pyridinium group or a quaternary imidazolium group (an exchange group in which the counter ion is an anion) is introduced can be used without limitation.

  The non-working side electrode structure 14 includes a non-working side electrode 36 provided on one surface side of the non-working side base sheet 34, a second electrolyte solution holding unit 38, a third ion selective membrane 40, The third electrolyte solution holding part 42 and the fourth ion selective membrane 44 are laminated in this order, and are formed in a disc shape like the working electrode structure 12.

  The non-working side electrode 36 has the same configuration as the working side electrode 22 in the working side electrode structure 12, and the configuration and components of the second electrolytic solution holding unit 38 and the third electrolytic solution holding unit 42 are also included. The components are the same as those of the electrolytic solution holding unit 24, but the components are not necessarily the same.

  Further, the third ion selective membrane 40 is the same as the first ion exchange resin forming the first ion selective membrane 34, and the same ion exchange membrane as the first ion selective membrane 34. Function as.

  The fourth ion selective membrane 44 is made of a second ion exchange resin. The fourth ion selective membrane 44 functions as an ion exchange membrane similar to the second ion selective membrane 26.

  A working electrode terminal plate 22A is provided on the other surface of the base sheet 32. The working electrode terminal plate 22A is provided on the base sheet 32 with respect to the working electrode 22 of the working electrode structure 12. It is conducted through a through hole and is connected to the direct conduction source 16 through a power supply circuit 46.

  Similarly, a non-working electrode terminal plate 36 A is provided on the other surface of the non-working side base sheet 34, and this non-working electrode terminal plate 34 A is located on the non-working side with respect to the non-working side electrode 36. It is conducted through a through hole formed in the base sheet 34 and is connected to the DC power supply 16 through the power supply circuit 46.

  The drug solution holding part 28 and the first ion-selective membrane 30 in the working electrode structure 12 have a thickness (generally, the hole diameter is for the ear) at the central part thereof, the outer diameter of which substantially matches the hole diameter of the piercing hole 21. Is formed with a pin-like protrusion 48 having a diameter of 0.8 mm to 1.6 mm and a maximum of 12.7 mm for the body. The protrusion 48 is formed by providing a base protrusion 32 </ b> A protruding in the distal direction at the center of the base sheet 32.

  In addition, an insulating film 50 having an outer diameter larger than that of the protrusion 48 is provided at the tip of the non-working side electrode structure 14 that faces the protrusion 48.

  When the pin-type iontophoresis device 10 is used, the projection 48 of the working electrode structure 12 is inserted from one of the piercing holes 21 formed in the earlobe 20, for example, and the non-working side. The earlobe 20 is sandwiched with the electrode structure 14.

  At this time, since the central portion of the fourth ion selective film 44 is covered with the insulating film 50 at the tip of the non-working side electrode structure 14 facing the protruding portion 48, A part does not contact the piercing hole 21.

  When the DC power supply 16 is energized in the state as described above, the chemical solution held in the chemical solution holding unit 28 penetrates from the first ion selective membrane 30 into the inner peripheral surface of the pierce hole 21. Since this inner peripheral surface is a mucous membrane or a property close to the mucous membrane, the working electrode structure 12 has better adhesion than the outer skin, the barrier voltage during drug ion administration is lowered, and the efficiency of the DC power supply is improved. good.

  Although the working electrode structure 12 has good adhesion, the blood circulation amount of the earlobe 20 is very small compared to other parts of the living body, and the area of the inner peripheral surface of the pierce hole 21 is also small. The drug solution is not rapidly administered to the living body. In other words, since a small current is sufficient, the power source can be reduced in size and weight, and the burden on the user is small. This is suitable when drug ions are administered little by little for a long time.

  Reference numeral 50 in FIG. 2 denotes an insulating film disposed on the front surface of the first ion exchange membrane 30 so as to surround the protrusion 48. The insulating film 50 is for suppressing rash and the like around the piercing hole 21 and is not necessarily provided.

  The thickness of the protrusion 48 may be approximately the same diameter when the pierce hole 21 has a hole diameter of about 0.8 to 1.6 mm. Since the inner diameter of the pierced hole 21 can be increased by inserting the protruding part 48, the protruding part 48 having an outer diameter larger than the inner diameter of the pierced hole 21 when not attached may be used. In this case, the adhesion of the protrusion 48 to the inner peripheral surface of the piercing hole 21 is increased.

  Next, a pin type iontophoresis device 60 according to Embodiment 3 of the present invention shown in FIG. 3 will be described.

  The pin-type iontophoresis device 60 is provided with a pair of ring-shaped non-working side electrode structures 64 integrally connected in parallel to the outer periphery of the working side electrode structure 62, The protrusion 66 is configured to be inserted from both ends. A separator 63 is arranged between the outer periphery of the working electrode structure 62 and the inner periphery of the non-working electrode structure 64 so as to insulate and seal between the two.

  The working electrode structure 62, the separator 63, and the non-working electrode structure 64 are concentrically disposed on one surface of a common base sheet 68.

  As in the base sheet 32, a base protrusion 68A is formed at the center of the base sheet 68, and this forms the protrusion 48.

  Further, an insulating film 50 is provided on the plane of the first ion selective film 30 so as to surround the outside of the protrusion 48, so that the first ion selective film 30 and the skin of the earlobe 20 are not in contact with each other. .

  The description of other components will be omitted by attaching the same reference numerals to the same components as those in the pin-type iontophoresis device 10 shown in FIGS. In FIG. 3, the DC current 16, the working electrode terminal plate 22A, the non-working electrode terminal plate 36A, and the current circuit 46 are not shown.

  In this embodiment, since the protrusion 48 is inserted from both ends of the piercing hole 21 and the drug solution penetrates, the drug solution dose per unit time can be increased as compared with the case of the first embodiment.

  Next, a pin type iontophoresis device 70 according to Embodiment 3 of the present invention shown in FIG. 4 will be described.

  The pin-type iontophoresis device 70 according to the third embodiment includes an insulating film for the working electrode structure 72 having the same configuration as the working electrode structure 12 and the non-working electrode structure 14 in the first embodiment. It is comprised from the non-working side electrode structure 74 from which a structure differs.

  In the non-working side electrode structure 74, an insulating protrusion 76 made of an insulating material is provided at the center position of the fourth ion selective film 44 instead of the insulating film 50 in the first embodiment.

  Since other configurations are the same as the configuration of the pin type iontophoresis device 10 according to the first embodiment, the same reference numerals are given to the same portions, and the description will be omitted.

  In the pin-type iontophoresis device 70 according to the third embodiment, the protrusion 48 of the working electrode structure 72 and the insulating protrusion 76 of the non-working electrode structure 74 are in contact with the pierce hole 21 of the earlobe 20. The working electrode structure 72 and the non-working electrode structure 74 can be stably attached to the earlobe 20 because they are inserted so as to face each other.

  The insulating film 70 or the insulating protrusion 76 in the first and third embodiments may be any non-conductive portion that is not electrically connected to the mucous membrane inside the pierced hole 21. Accordingly, for example, the fourth ion A portion of the selectivity film 44 that faces the protrusion 48 may be a non-conductive portion that is a recess or a hole.

  Further, the non-conducting portion is for a case where the ion exchange membrane of the working side electrode structure and the ion exchange membrane of the non-working side electrode structure may be short-circuited via the inner peripheral surface of the piercing hole 21. If there is no short circuit, the non-conductive portion may not be used.

  Next, a pin type iontophoresis device 80 according to Embodiment 4 of the present invention shown in FIG. 5 will be described.

  The pin-type iontophoresis device 80 of the fourth embodiment includes a working electrode structure 82 similar to the working electrode structure 72 shown in FIG. 4, and a non-working side electrode in the first embodiment shown in FIG. The structure includes a non-working side electrode structure 84 provided with a non-working side projection 86 similar to the projection 48 in the working side electrode structure 72.

  The non-working side projection 86 forms a non-working side base projection 34A, similar to the base projection 32A, at the center of the non-working side base sheet 34 in the non-working side electrode structure 84. Further, the non-working side electrode 36, the second electrolyte solution holding unit 38, the third ion selective membrane 40, the third electrolyte solution holding unit 42, and the fourth ion selective film 44 are laminated to form the non-working side projection portion. 86 is formed.

  The configuration of the fourth embodiment is used when there is no possibility that the first ion selective membrane 30 and the fourth ion selective membrane 44 are short-circuited via the inner peripheral surface of the pierce hole 21.

  In particular, in this embodiment, since both the first ion selective membrane 30 and the fourth ion selective membrane 44 are in contact with the inner peripheral surface of the pierce hole 21, the impedance between them is small, so that the drug ion The barrier voltage during administration of can be further reduced.

  Next, a pin type intophoresis device 90 according to Embodiment 5 of the present invention shown in FIG. 6 will be described.

  The pin-type iontophoresis device 90 according to the fifth embodiment has a working electrode structure 82 and a non-working electrode structure 84 according to the fourth embodiment shown in FIG. It is provided by being shifted in a direction perpendicular to the non-working side projection 86.

  In the pin type iontophoresis device 90 according to the fifth embodiment, as shown in FIG. 6, when two piercing holes 21 are provided and are close to each other, the working electrode structure is provided on one side. The non-working side electrode structure 84 can be attached to the body 72 and the other. The non-working side electrode structure 84 is slidable in the vertical direction in FIG. 6 by the slide mechanism 85, and the power supply circuit 46 is partially coiled so that it can extend and contract during sliding.

  In the case of the fifth embodiment, since there is no short circuit between the first ion selective membrane 30 and the fourth ion selective membrane 44, the projecting portion 48 and the non-working side projecting portion 86 are long, for example, the entire length range of the pierce hole 21 Can be configured to contact.

  Next, a pin type iontophoresis device 100 according to Embodiment 6 of the present invention shown in FIG. 7 will be described.

  The pin-type iontophoresis device 100 includes a working electrode structure 102 having a thin rod-like protrusion 103 and a non-working electrode structure 74 that is the same as in the third embodiment.

  The protrusion 104 has a thin rod-like working electrode 106 at the center, and around the working electrode 106, an electrolyte solution holding unit 108, a second ion selective membrane 110, a chemical solution holding unit 112, a first The ion selective membrane 114 is formed by stacking in a cylindrical shape in this order from the inside.

  In the pin type iontophoresis device 100 according to the sixth embodiment, the elongated ion-like first ion selective membrane 114 is in contact with the inner peripheral surface of the pierce hole 21, so that the contact area becomes large, and drug ions Can be administered in a short time.

  In Example 6 as well, if the length of the protrusion 103 can be shortened to such an extent that a short circuit does not occur with the non-working side electrode structure 74, the non-working side electrode structure 74 is also similar to the protrusion 103. A protrusion may be formed.

  In the working electrode structure in the above embodiment, the electrolytic solution holding unit, the second ion selective membrane, and the chemical solution holding unit are provided between the working electrode and the first ion exchange membrane. However, the present invention is not limited to this, and the present invention is also applicable to the case where the electrolytic solution holding part and the second ion selective membrane are not provided. The same applies to the non-working side electrode structure.

  In all of the above examples, drug ions are administered using a pierced hole formed in the ear of a human body, but the present invention is not limited to this, and mammals including humans can be used. The present invention is applied to a case where a hole is artificially formed in a living body and drug ions are administered from the inner peripheral surface of the hole by iontophoresis.

  Therefore, the present invention is also applied to livestock such as cows, horses, dogs, and pets when piercing holes other than the earlobe of the human body or other artificial holes are used.

  In addition, when the earring type iontophoresis device is attached to the earlobe as in the above embodiment, as described above, the barrier voltage at the time of administration is low, and the DC power source can be reduced in size and weight. Can be administered for a long time.

The perspective view which shows the outline of the pin type iontophoresis apparatus based on Example 1 of this invention. Sectional drawing which expands and shows the state which mounted | worn the pin type iontophoresis apparatus to the earlobe The expanded sectional view similar to FIG. 2 which shows the pin type iontophoresis apparatus based on Example 2 of this invention. The expanded sectional view similar to FIG. 2 which shows the pin type iontophoresis apparatus based on Example 3 of this invention. The expanded sectional view similar to FIG. 2 which shows the pin type iontophoresis apparatus based on Example 4 of this invention. The expanded sectional view similar to FIG. 2 which shows the pin type iontophoresis apparatus based on Example 5 of this invention. The expanded sectional view similar to FIG. 2 which shows the pin type iontophoresis apparatus based on Example 6 of this invention.

Explanation of symbols

10, 60, 70, 80, 90, 100 ... Pin-type iontophoresis device 12, 62, 72, 84, 102 ... Working electrode structure 14, 64, 74, 86 ... Non-working electrode structure 16 ... DC power source 21 ... piercing hole 22A ... working electrode terminal plate 22,106 ... working side electrode 24,108 ... electrolyte holding part 26,110 ... second ion selective membrane 28,112 ... chemical solution holding part 30,114 ... first Ion-selective membranes 32, 68 ... base sheet 34 ... non-working side base sheet 34A ... non-working side base projection 36 ... non-working side electrode 36A ... non-working electrode terminal plate 38 ... second electrolyte holding part 40 ... third ion Selective film 42 ... third electrolyte holding part 44 ... fourth ion selective film 46 ... power supply circuits 48, 66, 104 ... protrusions 50, 68 ... insulating film 52 ... non-acting side insulating film 76 ... insulating protrusions

Claims (10)

  A method of administering a drug ion, comprising artificially forming a hole in a living body and administering the drug ion by iontophoresis from an inner peripheral surface of the hole. In claim 1,
A method of administering a drug ion, wherein the living body is a mammal, a pierced hole is formed in an earlobe of the mammal, and a drug ion is administered from the inner peripheral surface of the pierced hole by iontophoresis. Working and non-working electrode structures used to administer drug ions by iontophoresis, and DC power supplies connected to these working and non-working electrode structures with different polarities And having
The working electrode structure includes a working electrode connected to the same kind of polarity as the drug ion in the DC power source, a drug solution holding unit electrically connected to the working electrode and holding the drug ion, At least a first ion-selective membrane that is disposed in front of the drug solution holding unit and selectively allows the same kind of ions as the drug ions to pass through;
At least a part of the first ion selective membrane and the chemical solution holding part is a pin-shaped protrusion having a thickness that can be inserted into a hole formed in a living body, and the first ion selective film of the protrusion A pin-type iontophoresis device characterized in that a chemical solution in a chemical solution holding part can be administered. In claim 3,
A pair of working-side electrode structures are provided, and these are arranged so that the protrusions face each other, and a pin-type iontophoresis device. In claim 3,
The working-side electrode structure and the non-working-side electrode structure are arranged with their tips facing each other, and the non-working-side electrode structure has a tip-facing portion that is opposed to the protruding portion and a non-conductive portion. A pin-type iontophoresis device comprising an ion-selective membrane. In claim 5,
The non-working-side electrode structure has a pin-shaped opposing protrusion at the tip, made of an insulator, at a position facing the protrusion in the working-side electrode structure and having substantially the same diameter as the protrusion. Pin-type iontophoresis device characterized by In claim 3,
The non-working side electrode structure is
A non-working electrode connected to the opposite polarity to the charged ion of the drug ion in the DC power source;
An electrolyte solution holding unit that is electrically connected to the non-working side electrode and holds the electrolyte solution,
A non-working side ion-selective membrane that is disposed on the front surface of the electrolyte solution holding unit and selectively passes ions opposite to the charged ions of the drug ions, and
At least one of the non-working side ion-selective membrane and the electrolyte solution holding part is a non-working side protrusion having a thickness that can be inserted into the piercing hole,
The working-side electrode structure and the non-working-side electrode structure are such that the protrusions and the non-working-side protrusions at the tips of each other are shifted in a direction perpendicular to the central axis of these protrusions, and A pin-type iontophoresis device characterized by being arranged to face each other. In any of claims 5 to 7,
A pin-type iontophoresis device comprising: a clamping device that supports the working electrode structure and the non-working electrode structure so as to be urged or clamped in a direction in which the distal ends approach each other. In any of claims 3 to 8,
The protrusion in the working electrode structure is configured by laminating at least the chemical solution holding portion and the first ion selective membrane in this order on the outer periphery of the thin rod-shaped working electrode. A pin-type iontophoresis device. In any one of Claims 3 thru | or 9,
The working electrode structure includes the working electrode, an electrolyte solution holding unit that is disposed on the front surface of the working electrode and holds an electrolyte solution,
A second ion-selective membrane that is disposed in front of the electrolyte solution holding unit and selectively allows ions opposite to the drug ions to pass therethrough;
The chemical solution holding part disposed on the front surface of the second ion selective membrane;
The first ion exchange membrane disposed on the front surface of the chemical solution holding unit;
Having
The non-working side electrode structure is
A non-working side electrode connected to the opposite polarity to the drug ion in the DC power source;
A second electrolyte solution holding unit disposed on the front surface of the non-working side electrode and holding the second electrolyte solution;
A third ion-selective membrane that is disposed in front of the second electrolyte solution holding unit and selectively passes ions of the same kind as the drug ions;
A third electrolyte solution holding unit disposed on the front surface of the third ion selective membrane and holding the third electrolyte solution;
A fourth ion-selective membrane that is disposed on the front surface of the third electrolyte solution holding unit and is a non-acting side ion-selective membrane that selectively passes ions opposite to the drug ions;
A pin-type iontophoresis device characterized by comprising:

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