JP2007113979A - Multispectral analyzer - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a multispectral analyzer constituted so as to precisely analyze a treatment fluid in a continuous treatment system in a real time to monitor a manufacturing line with high precision. <P>SOLUTION: The multispectral analyzer 1 is equipped with a light source part 24 having a large number of light sources 24a-24g different in wavelength, a casing 10 having a flow cell 14, which permits a liquid to be measured to flow, formed thereto, a large number of the light emission parts 20 and light detection parts 22 approaching the liquid to be measured in the flow cell 14, a spectroscopic part 28 having spectroscopes 28a-28g for individually diffracting the beams of light with respective wavelengths extracted from the light detection parts 22 spectrally and a control part 32 for operationally controlling the spectral data of the liquid to be measured obtained from the spectroscopes 28a-28g. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a multispectral analysis apparatus used in a microreactor apparatus that reacts fluids in a micro space in a continuous flow field.

  The Reynolds number is small in a minute space flow channel of several tens to several hundreds of μm, the flow becomes laminar, and mixing by molecular diffusion becomes rate-limiting. In organic synthesis reactions and biochemical reactions, in a process where two or more fluids are mixed and reacted, laminar flow diffusion using a microspace is more mixed than conventional mechanical stirring and mixing in reactions where the reaction rate is fast. Efficiency is good. If the mixing efficiency is improved, side reactions can be suppressed as compared with the batch-type organic synthesis reaction using a conventional reaction kettle, so that the reaction yield and selectivity are significantly improved. Therefore, the microreactor has been used as one suitable for manufacturing pharmaceutical products and similar products.

  By the way, of course, sufficient quality control is required for the manufacture of pharmaceutical products and similar products. The management method in such a case has been written as GMP (Proper Manufacturing Standard) in, for example, the FDA (Food and Drug Administration). The basic idea of GMP is to guarantee quality reproducibility, and the quality must be uniform within a lot.

  In the conventional batch processing, it is technically estimated that the quality of the same lot in the reaction kettle is uniform. Therefore, a sampling investigation should be performed to confirm this. However, in continuous processing such as a microreactor, it is difficult to estimate that the quality is uniform. Therefore, a means for analyzing the manufactured liquid product in real time is required. Thus, for example, it is conceivable to use a spectroscopic analyzer that irradiates light from a light source and measures wavelength absorption characteristics. However, in a spectroscopic analyzer using a single light source, the light is concentrated and distributed in a certain wavelength region, so the sensitivity in the peripheral region is lowered, and thus the generation of unpredictable side reaction products is sufficiently monitored. I couldn't.

  The present invention has been made in view of the above circumstances, and can analyze a processing fluid in a continuous processing system such as a microreactor in real time with high accuracy and can monitor a production line with high accuracy. The purpose is to provide.

  In order to achieve the object, the multispectral analysis apparatus according to claim 1 is a multispectral analysis apparatus for evaluating organic synthesis reaction results in a pharmaceutical / pharmaceutical production line and a pharmaceutical development stage, and having a plurality of wavelengths. A light source unit having different light sources, a casing constituting a flow cell for circulating the liquid to be measured, a plurality of light emitting units and light receiving units in the flow cell that are close to the liquid to be measured, and a spectrum of each wavelength obtained from the light receiving unit It is characterized by comprising a spectroscopic unit having a spectroscope to be performed individually, and a control unit for calculating and outputting spectroscopic information of the liquid to be measured obtained by the spectroscope.

  In the first aspect of the present invention, a plurality of light beams having different wavelength regions are emitted from the light source unit, received by different spectroscopes, and each wavelength spectrum that has passed through the liquid to be measured is individually performed. By combining such a plurality of pieces of analysis information, a highly accurate and leak-free analysis is performed.

A multispectral analyzer according to a second aspect of the present invention is the multispectral analysis apparatus according to the first aspect, wherein the light source unit is at least two of ultraviolet light, visible light, near infrared light, infrared light, and far infrared light. A light source covering at least one wavelength region is provided.
In invention of Claim 2, it combines the light source which covers at least 2 or more wavelength range among ultraviolet light, visible light, near infrared light, infrared light, and far infrared light from a light source part. The analysis information according to the processing object and purpose can be obtained.

A multispectral analyzer according to claim 3 is the invention according to claim 1 or 2, wherein a plurality of the flow cells are formed, and a light emitting portion and a light receiving portion are arranged in each flow cell, respectively. To do.
A multispectral analysis apparatus according to a fourth aspect of the present invention is the invention according to any one of the first to third aspects, wherein the casing is configured to form a plurality of flow cells inside by a partition. Features.

A multispectral analyzer according to a fifth aspect of the present invention is the invention according to any one of the first to fourth aspects, wherein the casing is configured to form one flow cell therein, and a plurality of the casings are provided. It is characterized in that it can be detachably mounted on the substrate.
The multispectral analyzer according to claim 6 is the invention according to any one of claims 1 to 5, wherein the light source from the visible region to the near-infrared region is also used as one light source and led to different light receiving units. It is configured as described above.

A multispectral analyzer according to a seventh aspect is characterized in that in the invention according to any one of the first to sixth aspects, a distance between the light emitting unit and the light receiving unit can be adjusted.
A microreactor according to claim 8 has the multispectral analysis apparatus according to any one of claims 1 to 7 on the downstream side of the reaction region.

  According to the multispectral analysis apparatus according to any one of claims 1 to 7, a plurality of lights having different wavelength regions are received by different spectroscopes from the light source unit, and the spectrum of each wavelength that has passed through the liquid to be measured is individually received. By doing so, the processing fluid in a continuous processing system such as a microreactor can be analyzed with high accuracy in real time, and the production line can be monitored with high accuracy.

  According to the microreactor described in claim 8, various measures can be quickly taken based on highly accurate analysis information obtained by the multi-spectral analyzer, and a highly reliable product can be produced.

Embodiments of the present invention will be described below with reference to the drawings.
FIG. 1 schematically shows a multispectral analysis apparatus 1 according to an embodiment of the present invention, and is configured in, for example, a casing 10 constituted by a pair of substrates. As shown in FIG. 10 described later, the spectroscopic analyzer 1 is used by being incorporated into a part of a member constituting a downstream portion of the microreactor 2.

  In the casing 10, a plurality of flow cells 14 connected to a flow path (flow path through which a reaction product flows) 12 on the downstream side of the microreactor 2 are formed. The flow cell 14 is formed by partitioning a rectangular plate-like internal space 16 as a whole by a plurality of partitions 18, and a light emitting unit 20 and a light receiving unit 22 are arranged on opposite sides of the flow cell 14. In this embodiment, it is possible to reduce the size by accommodating the plurality of flow cells 14 in the internal space 16 in one casing 10, and it is possible to improve the analysis accuracy by suppressing the flow rate variation. . The flow path in the flow cell 14 is preferably shaped so that there is no stagnant flow or passage resistance as much as possible.

  The material constituting the casing 10 is preferably one that has excellent thermal conductivity and can withstand a wide temperature range of −40 to 150 ° C. Furthermore, the material constituting the flow path of the flow cell 14 is preferably one that can withstand the high pressure of the liquid. Considering these points, preferable examples of the material constituting the flow path include SUS316, SUS304, Ti, quartz glass, Pyrex (registered trademark) glass and other hard glass, PEEK (polyetheretherketone), PE (polyethylene), PVC ( Examples thereof include resins such as polyvinylchloride), PDMS (Polydimethylsiloxane), Si, PTFE (polytetrafluoroethylene), PCTFE (Polychlorotrifluoroethylene), and PFA (perfluoroalkoxylalkane).

  A light source unit 24 having a plurality of light sources 24 a to 24 g that output light of different wavelength ranges is installed at a predetermined location near the flow cell 14, and each output light is guided to the light emitting unit 20 by an optical fiber 26. Yes. In this embodiment, the light source 24a that outputs ultraviolet light is a deuterium lamp, the light sources 24b to 24e that output near infrared light from visible light are halogen lamps, and the infrared light is a nichrome infrared light source 24f. is there. A single halogen lamp may cover from visible light to near infrared light. By doing so, the size of the apparatus can be made more compact.

  The light receiving unit 22 is coupled by an optical fiber 26 to a spectroscopic unit 28 having spectroscopes 28 a to 28 g installed in the vicinity of the flow cell 14. The spectroscopes 28a to 28g are constituted by, for example, CCD elements, and can measure the intensity by dividing the light received by each of the wavelength bands. In this embodiment, seven spectroscopes 28a to 28g are installed, and the wavelength ranges shared by the spectroscopes 28a to 28g are 200 to 400 nm (ultraviolet spectroscope 28a) and 400 to 700 nm (visible light spectroscope). 28b), 700-1000 nm (first near infrared spectrometer 28c), 1000-1700nm (second near infrared spectrometer 28d), 1700-2200nm (third near infrared spectrometer 28e), 2200-25000nm (red) The outer spectroscope 28f) and the wavelength region exceeding the wavelength of 25000 nm (far infrared spectroscope 28g). It is not necessary to cover all of these combinations depending on the substance to be measured, and any combination of two or more appropriate numbers may be used.

  In this embodiment, the optical path between the light emitting unit 20 and the light receiving unit 22 is formed in the fluid flow direction, and can be set according to a predetermined optical path length regardless of the flow path width. Further, the adjustment of the optical path length for each section flow path can be performed by changing the protruding lengths of the light emitting unit 20 and the light receiving unit 22. For example, in the ultraviolet spectrometer 28a, the sample solution is usually diluted and analyzed off-line. However, in the in-line measurement, since the concentration remains high, the optical path length is shortened in order to avoid unnecessary reactions. Measure (for example, 1 mm or less). Further, since the near-infrared spectrometers 28c to 28e have relatively low sensitivity, the optical path length is set long (5 to 10 mm). As will be described later, in order to instantaneously simultaneously measure a plurality of components having a wide absorption wavelength, it is necessary to set the shape and dimensions of the flow cell 14 in accordance with the pros and cons of each wavelength region.

  From each of the spectroscopes 28 a to 28 g, light reception intensity for each preset wavelength region is output and input to the control unit 32 via the AD converter 30. The control unit 32 calculates the transmittance (absorption rate) based on this data and the intensity distribution data for each wavelength region of the light sources 24a to 24g inputted in advance, and based on this, the target reaction is calculated. The production amount of the product (regular product) and the production amount of the reaction by-product are obtained, and as a result, the yield, conversion rate, and secondary solvent concentration are also obtained.

  Since the reaction products and reaction by-products are narrowed down in advance unless they are experimental, a combination of the light sources 24a to 24g and the spectroscopes 28a to 28g prepared for wavelength absorption corresponding to the components to be generated is used. Use it. In this case, even if there are a plurality of reaction by-products and the possibility of being generated is low, it is desirable to install them in order to clear GMP (Appropriate Manufacturing Standard) of FDA (US Food and Drug Administration), for example.

  On the other hand, in the development stage of pharmaceuticals, there is an operation of finding a reaction that may be referred to as so-called screening by changing various conditions such as reagent type, concentration, temperature, and flow rate. As described above, when it is impossible to predict what kind of reaction product is generated, the light sources 24a to 24g and the spectroscopes 28a to 28g in all wavelength regions are installed in advance so that an arbitrary product can be detected. After data is accumulated, take measures such as removing unnecessary ones or replacing them with appropriate ones.

  The control unit 32 displays data such as the production amount, yield and conversion rate of reaction products and reaction by-products on the display 34 and stores them in the storage device 36, and these data exceed a preset threshold value. If a warning is generated, an alarm is generated by the alarm device 38, and if the threshold is exceeded, the processing is automatically stopped. Furthermore, the correlation between the above data and reaction conditions may be obtained in advance, and the reaction conditions of the microreactor, for example, reaction temperature, flow rate, pressure, etc. may be controlled based on the detection data.

  In general, in the spectroscopic analyzer 1 using a single light source, the light is concentrated and distributed in a certain wavelength region, so the sensitivity in the peripheral region is lowered. In the multispectral analysis apparatus 1, since the light sources 24a to 24g and the spectroscopes 28a to 28g having different wavelength ranges are provided, accurate data can be obtained over a wide wavelength range. Hereinafter, characteristics of the spectroscopes 28a to 28g and a combination method based on the characteristics will be described with reference to Table 1. Table 1 illustrates the absorption spectrum wavelength of each functional group, molecule, etc.

  The ultraviolet spectrometer 28a is suitable for reading the absorption spectrum tendency of all components and detecting the change in yield and the amount of impurities. The infrared spectrometer 28f can cope with many organic functional groups of individual substances, but there are cases in which the intensity is too strong and interference substances are emitted. In that case, the near-infrared spectrometers 28c to 28e are substituted. In addition, when the solvent is water, the infrared spectrometer 28f may cause water to be an obstructing substance. The visible light spectrometer 28b is suitable for detecting colored substances such as chlorophyll and carotene. In this embodiment, the reason why the three near-infrared spectrometers 28c to 28e are properly used is that a portion having a weak measurement ability is not formed in the near-infrared region 700 to 2200 nm. This is to accurately read small shifts in the peak due to lengthening or subtle changes in coupling.

  Hereinafter, a more specific reaction will be described with reference to FIG. The reaction in FIG. 2 (a) is an overreaction reaction performed in a solvent pyridine, and if a positive reaction is performed based on the microchannel effect, monobenzoylresorcinol is produced. However, the concentration imbalance in the microchannel is not improved. When it occurs, the reaction further proceeds to produce dibenzoyl resorcinol, which is a side reaction. The formation of functional groups such as benzene ring, CO, OH, etc. can be determined by measuring the absorption region, and the ratio of mono- and di-forms can be detected. Although the benzene ring can be measured by the infrared spectrometer 28f, there is a possibility that the solvent pyridine may be detected as a background, and measurement may be impossible or it may be difficult to distinguish due to overlapping peaks. In that case, the near-infrared spectrometers 28c to 28e may be used.

  In the above case, the specific wavelength region where the difference in absorption intensity is sufficiently large between the number of benzoyl groups of 1 and 2 is, for example, the near-infrared spectrometers 28c to 28e or the infrared spectrometer 28f. If it exists in the area, it may be selected. In this case as well, the absorption spectrum of the entire reaction system liquid is monitored by the ultraviolet spectrometer 28a, and if there is a change in the reaction, an alarm is issued or the process is stopped.

In the reaction of FIG. 2 (b), benzylphenylalanine is reacted with hydrogen gas in methanol and reduced to yield phenylalanine methyl ester. This is a deprotection reaction of the protecting group with catalytic hydrogen, and a Pd catalyst is used. If you read the ratio of NH ₂ and NH, you can see the reaction rate. The strong NH ₂ can be read by the near-infrared spectrometers 28c to 28e, and the weak NH can be read by the infrared spectrometer 28f. Depending on the overlap of the interference substances, the near-infrared spectrometers 28c to 28e It is possible to use the spectroscope 28f properly. Of course, both components may be measured individually in their respective wavelength ranges. In this case as well, the absorption spectrum of the whole liquid is monitored by the ultraviolet spectrometer 28a, and if there is a change in the reaction, an action such as issuing an alarm or stopping the process is performed.

  The reaction of FIG. 2 (c) is a hydrolysis reaction in which water is added to glycine anhydride and hydrochloric acid is used as a catalyst to turn into glycylglycine in one step of polypeptide synthesis. Since the reaction is in the presence of water in the product, avoid the infrared spectrometer 28f where water is likely to interfere with absorption, and use a region that is not sensitive to water and has a weak sensitivity in the near-infrared spectrometer 28c to 28e region. And measure.

  FIG. 3 shows a modification of the embodiment of FIG. 1, in which the flow cells 14 are individually formed in the casing 10, and the fluid flow paths are branched and guided to the respective flow cells 14. As a result, each flow cell 14 is not affected by the other flow cells 14 and the flow resistance is small, so that the flow of fluid becomes more uniform. Further, as shown in the figure, by individually installing a flow rate adjusting valve 42 in the branch flow path 40 to the flow cell 14, the flow rate can be adjusted to an appropriate flow rate according to the characteristics of the spectroscopes 28a to 28g.

  FIG. 4 also shows a modification of the embodiment of FIG. 1, and the flow cell 14 is individually formed in the casing 10, but an open / close valve 44 is installed in each branch flow path 40. Thereby, only the opening / closing valve 44 of the flow cell 14 having the necessary wavelength is opened, and the unnecessary opening / closing valve 44 of the flow cell 14 is closed, thereby preventing the occurrence of excessive flow path resistance. In the embodiment shown in FIG. 5, the flow cells 14 are connected in series. In this embodiment, since there is no need for branching, there is an advantage that it is easy to handle if only the flow path resistance is taken into consideration.

  FIG. 6 shows the structure of the multispectral analysis apparatus 1 according to another embodiment. A plurality of casings 46 constituting one flow cell 14 are arranged on a substrate 47. Each casing 46 is formed of a transparent material such as quartz glass, and a flow path 48 is formed therein. The flow path 48 is opened at a side surface to form a joint portion 50. Inside the casing 46, the light emitting unit 20 and the light receiving unit 22 are placed with a flow path 48 interposed therebetween, and these are connected to an external light source and a spectroscope (not shown) by an optical fiber 26.

  In this case, the width of the flow path 48 is an optical path length through which light traverses. The joint 50 is connected to a microreactor or the like by piping. The material of the casing 46 may be PCTFE, PTFE, or PEEK having chemical resistance. In this case, the light emitting unit 20 and the light receiving unit 22 are protected by quartz so as not to be in direct contact with liquid. In this embodiment, since the connection to the flow path 48 is performed via the joint portion 50, the connection can be freely changed. The flow of the fluid to each flow cell 14 may be a parallel branch or may be in series, and an on-off valve 44 may be provided for each flow cell 14 to selectively flow.

  FIG. 7 shows a modification of FIG. 6 in which the light emitting unit 20 and the light receiving unit 22 are protruded into the flow channel 48 in order to set the optical path length short. In this case, in order to reduce stagnant flow and flow path resistance in the flow cell 14, a tapered portion 49 is formed to gradually increase the diameter of the flow path 48.

  FIG. 8 shows a modification of FIG. 6, and the optical path length can be freely adjusted in each of the casings 46 arranged on the substrate 47. The light emitting case 52 and the light receiving case 54 are arranged to face each other with the flow path 48 in the flow cell 14 interposed therebetween. Both the light emitting case 52 and the light receiving case 54 are made of quartz, and the light emitting unit 20 is mounted in the light emitting case 52 and the light receiving unit 22 is mounted in the light receiving case 54. At least one of the outer shapes of the light emitting case 52 and the light receiving case 54 is a screw, and is screwed into a fixing nut 56 attached to the outer surface of the case 46. Thereby, it is possible to freely adjust the length of the optical path length. The opposite side may be adjusted by fixing one side, or both sides may be adjustable. As a result, it is possible to freely adjust on-site individually from the sensitivity, molecular concentration, and solvent substance information of each wavelength region. Since a liquid having a high concentration is generally analyzed in-line, the optical path length is shorter than that in the off-line case, and is set to 10 mm to 0.1 mm, preferably 5 mm to 0.5 mm.

  FIG. 9A shows an embodiment of how to use the multispectral analysis apparatus 1 of the present invention. Rapid cooling is performed on the downstream side of the mixing / reaction unit 58 of the microreactor 2 in order to stop the continuation of the reaction. The micro quench part 60 to perform is installed. The micro quench part 60 can be made into the structure of the water cooling jacket 61 as shown in figure, for example. In this embodiment, by installing the multi-spectral analyzer 1 between the mixing / reaction unit 58 and the micro-quenching unit 60, the target product can be obtained by performing the micro-quenching after confirming the progress of the reaction. Can be manufactured stably.

  FIG. 9B shows another embodiment of how to use the multispectral analysis apparatus 1 of the present invention. The multispectral analysis apparatus 1 is installed downstream of the mixing / reaction unit 58 of the microreactor 2. Further, a three-way switching valve 62 is installed on the downstream side. The three-way switching valve 62 switches the line from the multispectral analyzer 1 so as to be selectively connected to the normal product storage line 64 and the spare line 68 connected to the spare tank 66. The output signal of the multispectral analyzer 1 is sent to the control unit 32. When the control unit 32 determines that there is an abnormality in the component, the three-way switching valve 62 is switched to the spare tank 66 side. Thereby, it is possible to prevent abnormal components from being mixed into the product storage line 64.

  Next, a fluid reaction apparatus (microreactor) 2 incorporating the multispectral analysis apparatus 1 according to the embodiment of the present invention described above will be described. FIG. 10 to FIG. 12B are diagrams showing the overall configuration of the fluid reaction device 2. In addition, the fluid reaction apparatus 2 described below is an apparatus used for mixing and reacting two or more kinds of liquids.

  As shown in FIGS. 10, 11, 12 (a), and 12 (b), the fluid reaction device 2 is installed in a single installation space and packaged. In this configuration example, the installation space is rectangular and is divided into four regions along the longitudinal direction. In other words, the first region on one end side is the raw material storage unit 101 in which a plurality of storage containers 110 (only two storage containers 110A and 110B are shown in FIG. 10) for storing the raw material liquid are installed, and are adjacent thereto. The second region is the liquid distribution unit 102 in which pumps 116A and 116B for transferring the raw material liquid in the storage container 110 are installed. A third region adjacent to the second region is a processing unit 103 having a mixing unit (mixing chip) 140 that mixes the raw material liquid and a reaction unit (reaction chip) 142 that reacts the mixed raw material liquid. . The fourth region on the other end side is a product storage unit (recovery container installation space) 104 for deriving and storing a product obtained as a result of the processing.

  The fluid reaction device 2 also includes an operation control unit 106 that is a computer that controls the operation of each unit, and a heat medium controller 107 that adjusts the temperature of the processing unit 103 by flowing a heat medium through the temperature adjustment case 146. Yes. Further, as shown in FIG. 10, the operation control unit 106 includes a flow rate monitor 270 and a temperature monitor 272 that can monitor the flow rate and temperature of the liquid. In this configuration example, the operation control unit 106 and the heat medium controller 107 are provided separately from the fluid reaction device 2, but may be integrated as a matter of course. As shown in FIG. 11, a piping chamber 105 is formed in the lower floor portion of the second to fourth regions, where piping for sending a heat medium for heating or cooling to the mixing unit 140 and the reaction unit 142 is provided. Is provided. The operation control unit 106 and the control unit 32 of the multispectral analyzer 1 are separate, but may be integrated.

  In this way, by arranging the respective parts from the upstream side to the downstream side, the flow of the liquid can be made smooth, and the entire apparatus can be made compact. In this configuration example, each part is arranged in a straight line. However, for example, if the entire space is close to a square, each part may be configured such that the liquid flow forms a loop.

  In FIG. 11, reference numeral 250 denotes a liquid storage pan provided at the lower part of the apparatus, and reference numeral 252 denotes a liquid leakage sensor installed on the liquid storage pan 250. In this example of the apparatus, the liquid distribution unit 102, the processing unit 103, and the product storage unit 104 are partitioned by partition walls 254 and 256, and covers 258, 260, and 262 are attached to the respective parts to isolate them from the outside of the apparatus. is doing. Reference numeral 264 denotes an exhaust port, which is connected to an exhaust fan (not shown). And the toxic gas in the apparatus is prevented from leaking outside by making the pressure in the apparatus negative from the outside of the apparatus.

  Although the two storage containers 110A and 110B are installed in the raw material storage unit 101 shown in FIG. 10, three or more storage containers may be used as necessary. For example, the process can be continuously performed by storing the same liquid in two storage containers and using them alternately. Note that the raw material storage unit 101 may be provided with a cleaning liquid container 112 containing an organic solvent such as acetone for line cleaning, hydrochloric acid, pure water, or the like, or a pressure source 114 filled with nitrogen gas for purging. Further, the waste liquid container 136 may be placed in the raw material storage unit 101.

  In the liquid distribution part (introduction part) 102, pumps 116A and 116B connected to the storage containers 110A and 110B via transport pipes 121A and 121B are installed. Centrifugal pumps are used as the pumps 116A and 116B in FIG. In addition, the liquid distribution unit 102 includes flow rate adjusting devices 300A and 300B, relief valves 122A and 122B, pressure measurement sensors 124A and 124B, flow path switching valves 126A and 126B, and backwashing disposed downstream of the pumps 116A and 116B. A pump 130 is provided. The flow path switching valves 126A and 126B are connected to the cleaning liquid container 112 and the pressure source 114 in addition to the transport pipes 121A and 121B, respectively. The backwash pump 130 is used when the inside of the flow path of the mixing unit 140 or the reaction unit 142 is blocked by a product. The backwash pump 130 is connected to the cleaning liquid container 112 that stores the cleaning liquid, and is further connected to the outlet of the reaction unit 142 via the flow path switching valve 132. The cleaning liquid transferred by the backwash pump 130 flows in the opposite direction to the normal flow. That is, the cleaning liquid flows from the outlet of the reaction unit 142 toward the inlet of the mixing unit 140, passes through the flow path switching valves 126 </ b> A and 126 </ b> B, and enters the waste liquid storage container 136 from the waste liquid port 134 through a pipe (not shown).

  The backwash pump 130 is preferably a single piston pump so that the discharge pressure is high and the product can be removed by causing pulsation in the cleaning liquid. As the cleaning liquid, an organic solvent, hydrochloric acid, nitric acid, phosphoric acid, organic acid, pure water, or the like is preferably used. Examples of the organic solvent include acetone, ethanol, methanol and the like. The introduction port 240 shown in FIG. 10 is provided when pure water or hydrogen water is introduced from the outside, and can be used for cleaning instead of the cleaning liquid in the cleaning liquid container 112.

  FIG. 13 shows a mixing unit 140 for performing preheating (preliminary temperature adjustment) and mixing of the raw material liquid. The upper plate 144a, the middle plate 144b, and the lower plate 144c, which are three thin plate-like substrates, are shown in FIG. The mixing portion 140 having a total thickness of 5 mm is formed by bonding. In addition, all the flow paths described below are grooves formed on the surface of the intermediate plate 144b. The two inflow ports 147A and 147B formed through the upper plate 144a communicate with the two preheating channels 148A and 148B formed on the upper surface of the middle plate 144b, respectively. These preheating flow paths 148A and 148B each branch in the middle and expand, and merge again. Further, the preheating channels 148A and 148B communicate with the outlet channels 150A and 150B, respectively, and these outlet channels 150A and 150B communicate with the junction 152. The outlet channel 150A is formed on the upper surface of the middle plate 144b, and the outlet channel 150B is formed on the lower surface of the middle plate 144b.

  FIG. 14 is an enlarged view of the junction shown in FIG. As shown in FIG. 14, the merging portion 152 includes header portions 154 and 155 formed on the upper and lower surfaces of the middle plate 144b as arc-shaped grooves that communicate with the outlet flow paths 150A and 150B, and the header portions 154 and 155, respectively. It has a plurality of liquid separation channels 156 and 157 extending toward the center of the arc, and a merge space 158 where these liquid separation channels 156 and 157 merge. The liquid separation channels 156 and 157 and the merge space 158 are formed on the upper surface of the intermediate plate 144b, and the liquid separation channels 156 and 157 are alternately arranged. The header portion 155 on the lower surface side and the liquid separation channel 157 communicate with each other through a communication hole 157a penetrating the intermediate plate 144b. The merge space 158 is formed so that the width gradually decreases toward the downstream side, and communicates with an outflow port 160 formed through the middle plate 144b and the lower plate 144c.

  In the example shown in FIG. 14, five separation channels 156 and four separation channels 157 are alternately arranged on the opening surface 159 on the inlet side of the merge space 158. The two types of liquids respectively flowing out from the separation flow paths 156, 157 flow downstream while forming a striped flow in the merge space 158, and are forced as the flow path width of the merge space 158 gradually decreases. Both liquids are mixed. In this example, the flow path width of the merge space 158 finally reaches 40 μm. If the processing technology accuracy is increased, the flow path width can be reduced to 10 μm.

  15A is a plan view showing the reaction part shown in FIG. 10, and FIG. 15B is a cross-sectional view of the reaction part shown in FIG. In this example, two base materials 144d and 144e are joined to form a reaction portion 142 having a thickness of 5 mm. In this reaction part 142, the reaction flow path 162 meanders, and provides a long flow path efficiently. The reaction channel 162 has connecting portions 162a and 162c connected to the inlet port 164 and the outlet port 165, and a meandering portion 162b connected to the connecting portions 162a and 162c. The width of the connecting portions 162a and 162c is narrow. The width of the meandering portion 162b is wide. Accordingly, the liquid flows rapidly at the entrance / exit portion to prevent adhesion of by-products, and flows slowly at the meandering portion 162b so that the heating and reaction time can be increased.

  FIG. 16A and FIG. 16B show another configuration example of the reaction unit having a portion 163a where the width of the reaction channel gradually decreases and a portion 163b where the width of the reaction channel gradually increases. In the reaction portion 142a, a reaction channel 163 is formed between the base materials 144d and 144e so that the width dimension increases or decreases in the range from the maximum a to the minimum b. The depth may be increased or decreased according to the increase or decrease of the width dimension. In this example, the depth changes from the maximum c to the minimum d so that the cross-sectional area of the reaction channel 163 is constant.

  FIG. 16C is a cross-sectional view showing another configuration example of the reaction channel. In the reaction section 142b, the reaction channel 163c has a flat shape whose width e is larger than the depth f, and has a wide heat transfer surface intersecting the heat transfer direction (indicated by an arrow) from the thermal catalyst. Therefore, heat is effectively transmitted to the liquid in the reaction channel 163c. In addition, it is effective in order to accelerate | stimulate reaction to arrange | position an appropriate catalyst in the confluence | merging space 158 and the reaction flow paths 162,163. Such a catalyst is selected depending on the type of reaction. As for the arrangement method, for example, it can be applied to the inner surface of the channel, or can be arranged as an obstacle of the channel as described later.

  As a material for forming at least the flow path of the mixing unit 140 and the reaction unit 142, for example, SUS316, SUS304, Ti, quartz glass, Pyrex (registered trademark) glass or other hard glass, PEEK (polyetheretherketone), PE (polyethylene), Among PVC (polyvinylchloride), PDMS (Polydimethylsiloxane), Si, PTFE (polytetrafluoroethylene), and PCTFE (PolyChloroTriFluoroEthylene), a preferable one is selected in consideration of chemical resistance, pressure resistance, thermal conductivity, heat resistance, and the like. The material of the wetted part of the mixing part 140 and the reaction part 142 is preferably one that has little elution from the surface, can be modified with a surface catalyst, has a certain degree of chemical resistance, and can withstand a wide temperature range of -40 to 150? .

  FIG. 17 is a perspective view showing a configuration of a temperature adjustment case for adjusting the temperatures of the mixing unit and the reaction unit. In the following description, only the temperature adjustment case 146 for adjusting the temperature of the reaction unit 142 will be described, but the temperature adjustment case 146 for the mixing unit 140 has the same configuration, and redundant description thereof is omitted. To do. The temperature adjustment case 146 includes a case main body 172 in which a space 170 that accommodates the reaction portion 142 is formed, and a lid portion 174 that covers the space 170. Grooves 176 constituting the medium flow path are formed. A liquid supply path 178 and a drainage path 180 (see FIG. 10) communicating with the groove 176 are formed in the case main body 172. These liquid supply path 178 and the drainage path 180 are connected to the heat medium controller 107, respectively. Yes. The liquid supply path 178 communicates with the groove 176 of the lid portion 174 via the opening 179, and the drainage path 180 also communicates with the groove 176 of the lid portion 174 via an opening (not shown). In this example, the heat medium flowing through the groove 176 directly contacts the front and back surfaces of the reaction unit 142, and the reaction unit 142 is heated (or cooled) in a state of being completely accommodated in the temperature adjustment case 146.

  Although not shown, the heat medium controller 107 incorporates a control mechanism for controlling the temperature of the heat medium and a pump for transferring the heat medium. As shown in FIG. 10, the heat medium is supplied to the temperature adjustment case 146 of the mixing unit 140 and the reaction unit 142 after passing through the heat exchanger 182. The heat exchanger 182 can change the temperature of the heat medium supplied to the mixing unit 140 and the reaction unit 142 independently by changing the amount of city water for cooling, for example.

  18 (a) to 18 (d) show other examples of the temperature adjustment case 146. Here, the heat medium flow path 192 is formed inside the case main body 172 and the lid portion 174, respectively. Has been. As shown in FIG. 18C, the liquid supply path 178 has a double pipe structure in which the tip of the liquid supply pipe 188 is inserted, and communicates with the heat medium flow path 192 through a thin communication path 190. is doing. The drainage side has the same configuration. As shown in FIG. 18B, the temperature adjustment case 146 that accommodates the mixing unit 140 and the temperature adjustment case 146 that accommodates the reaction unit 142 are stacked and coupled via a bolt 194, a nut 195, and a spacer 196. ing.

  FIG. 18B shows a path for supplying and discharging the liquid to and from the mixing unit 140 and the reaction unit 142 housed in the temperature adjustment case 146. That is, each liquid flows into and out of the mixing unit 140 through the flow passage 198 formed through the temperature adjustment case 146. In addition, the liquid is circulated between the mixing unit 140 and the reaction unit 142 through the communication passage 200 that communicates with the flow passage 198 of the temperature adjustment case 146. FIG. 18D illustrates the structure of the liquid inflow portion and the outflow portion of the reaction section 142. In order to direct the liquid flow downward, the liquid inlet of the mixing unit 140 and the reaction unit 142 is normally formed on the upper surface and the outlet is formed on the lower surface.

  As shown in FIG. 10, the outlet 202 of the reaction unit 142 is connected to the product storage unit 104 via a recovery pipe 204. In the product storage unit 104, a recovery container 208 is provided on the downstream side of the heat exchanger 206 for cooling and the flow path switching valve 132. The product storage unit 104 in which the recovery container 208 is placed is isolated so as not to be affected by temperature and the like from other regions, and to prevent toxic gas that may be generated from the product from leaking to the outside. .

  FIG. 19 shows another configuration example of the product storage unit 104, and a plurality of collection containers 208 are installed on the turntable 212. In this example, there are two collection containers 208, and the actuator 214 that moves the rotary table 212 is a 180-degree rotary actuator. Of course, the number of collection containers 208 and the types of actuators 214 can be selected as appropriate. The operation control unit 106 shown in FIG. 10 determines the replacement timing of the recovery container 208 based on a signal from the liquid level detection sensor 211b that detects the liquid level of the recovery container 208, and uses the flow path switching valve 132 (see FIG. 10). The liquid flow is stopped, the stop of the liquid flow is confirmed by the optical fluid detection sensor 211 a provided downstream of the recovery port 210, and the actuator 214 is operated to move the other recovery container 208 below the recovery port 210.

  Next, a process of reacting a liquid (raw material liquid) such as a chemical solution with the fluid reaction apparatus 2 configured as described above will be described. The operation of the fluid reaction device 2 is basically automatically controlled by the operation control unit 106. First, in the raw material storage part 101, it prepares in storage container 110A, 110B which stored the raw material liquid. The temperature of the heat medium is set by the heat medium controller 107, the amount of city water passing through the heat exchanger 182 is adjusted to adjust the temperature of each heat medium, and the temperature adjustment case 146 of the mixing unit 140 and the reaction unit 142 is adjusted. Heat medium is circulated to maintain a predetermined temperature. The temperature of the heat medium is measured by temperature sensors 216 and 218 provided at the inlet of the temperature adjustment case 146.

  In this example, before supplying the raw material liquid to the processing unit 103, a cleaning liquid such as pure water is supplied to the flow paths in the mixing unit 140 and the reaction unit 142 to perform cleaning in advance. While cleaning the flow path, the temperature of the cleaning liquid is measured by the temperature sensor 220 at the outlet of the mixing unit 140 and the temperature sensor 222 at the outlet of the reaction unit 142, and the temperature of the cleaning liquid is fed back to the heat medium controller 107. In this way, the mixing unit 140 and the reaction unit 142 are adjusted to a predetermined temperature.

  After the temperature of the mixing section 140 and the reaction section 142 is adjusted and the cleaning of the flow path is completed, the flow path switching valve 132 is switched and the pumps 116A and 116B are driven to supply the raw material liquid in the storage containers 110A and 110B, respectively. Transport. The raw material liquid is adjusted to a predetermined flow rate by the flow rate adjusting devices 300 </ b> A and 300 </ b> B, and then reaches the recovery container 208 through the mixing unit 140, the reaction unit 142, the outlet port 202, and the recovery port 210. The flow path switching valve 132 is an automatic valve that is actuated by an actuator, and this operation can also be performed automatically.

  In the mixing unit 140, the raw material liquids are heated to a predetermined temperature in the preheating channels 148 </ b> A and 148 </ b> B (see FIG. 13), and then merged and mixed in the joining unit 152. At that time, as shown in FIG. 14, each liquid flows into the merge space 158 from the header portions 154 and 155 via the liquid separation flow paths 156 and 157. Since the cross section of the merge space 158 gradually decreases toward the downstream, micro-sized flows are mixed regularly and mixed rapidly according to Fick's law. In that state, when it flows into the reaction channel 162 of the reaction unit 142 maintained at a predetermined temperature, the reaction proceeds rapidly without being restricted by mass transfer or heat conduction. Therefore, it is sufficiently practical as a mass production means, and it is not necessary to carry out an explosive reaction with a high reaction rate at a low temperature. In this example, since the width of the reaction channel 162 is sufficiently wider than the width of the merge space 158, even when the reaction rate is low, the reaction can be performed over a sufficient amount of time, resulting in a high yield. Obtainable.

  The obtained product is sent from the outlet 202 of the reaction channel 162 to the multispectral analyzer 1 via the recovery pipe 204 and receives a plurality of lights having different wavelength regions from the light source unit 24 by different spectroscopic units 28. Then, the spectrum of each wavelength that has passed through the liquid to be measured is performed, the contained components are measured based on the result, and various measures as described are performed based on the result.

  The processing liquid that has passed through the multispectral analyzer 1 is sent to the heat exchanger 206, where it is cooled and flows into the recovery container 208 through the recovery port 210. When the storage containers 110A and 110B are emptied or the recovery container 208 is full, the operation control unit 106 stops the operation of the pumps 116A and 116B and ends the processing. In this case, if an additional storage container is prepared in the raw material storage unit 101 in addition to the storage containers 110A and 110B, the flow path switching valves 126A and 126B can be switched to continuously operate without stopping. Processing is possible. In addition, when reaction takes time, it is also possible to carry out batch operation by confining the liquid in the mixing unit 140 and the reaction unit 142 for a certain period of time. Since the flow path switching valves 126A and 126B are also automatic valves, these operations can be automatically operated.

  In the batch operation method, the pumps 116 </ b> A and 116 </ b> B may be temporarily stopped, or the flow switching valves 126 </ b> A and 126 </ b> B may be switched to stop the flow of liquid into the processing unit 103. This eliminates the need to increase the length of the reaction channel 162 even when the reaction time of the liquid is long. In batch operation, it is preferable to perform operation control using a fullness detection means for detecting that the merge space 158 and / or the reaction flow path 162 is filled with liquid. For example, an optical fluid detection sensor as shown in FIG. 19 is used. Thus, when it is determined that the merge space 158 and / or the reaction flow path 162 is filled with the liquid, the pumps 116A and 116B are stopped or the first flow path switching valve is switched to adapt the liquid to the reaction end time. It stays in the merge space 158 and / or the reaction channel 162 for a certain time.

  FIG. 20A and FIG. 20B show another configuration example of the merging unit in the mixing unit 140. The junction 152a is configured by disposing obstacles 224 over a predetermined distance L at a constant interval a in a Y-shaped junction space 158a. In this example, a columnar obstacle 224 having a diameter of 50 μm or less was arranged over L = 5 mm from the junction. As shown in FIG. 20B, the obstacles 224 are arranged in a staggered manner so that adjacent ones are shifted by half the pitch in the flow direction. As a result, the interface 125 of the liquid A and the liquid B meanders, so that the interface area (contact area) between the two liquids can be increased. In the merging portion 152b shown in FIG. 21, a row of obstacles 224 are arranged in a zigzag along the flow direction in the central portion of the merging space 158b, and the interface area can be similarly increased. This is suitable for use in the narrow merge space 158b.

  FIG. 22 shows another configuration example of the processing unit 103 of the fluid reaction device 2. In the processing unit 103 of FIG. 10, two systems R1 and R2 each having a combination of a mixing unit 140 and a reaction unit 142 are provided, and two types of flow path switching valves 126A and 126B of the liquid distribution unit 102 are used. The raw material liquid can be supplied to any of the systems R1 and R2. As described above, by using the two systems, the processing amount can be increased as necessary, but there are various other usage methods. For example, when the reaction product easily deposits solid particles and is easily clogged in the middle of the piping, one system is used as a spare. Further, the batch operation described above can be continuously performed by alternately switching the transfer lines by the flow path switching valves 126A and 126B. Of course, three or more transfer lines can be provided in parallel as appropriate. In this case, the flow path switching valves 126A and 126B can be automatically operated.

  FIG. 23 shows an example in which a plurality of reaction units are arranged in series in the processing unit 103. In this example, one mixing unit 140 and three reaction units 142a, 142b, and 142c are connected in series, and temperature sensors 220, 222a, 222b, and 222c are provided respectively. In this example, it is possible to independently control the temperatures of the reaction units 142a, 142b, 142c according to the stage of the reaction. This configuration is suitable for reactions that require a bold and instantaneous change in reaction time and reaction temperature, such as biochemical reactions. For example, in this system, the reaction can be performed at 100 ° C. in the reaction unit 142a and at −20 ° C. in the reaction unit 142b.

  FIG. 24 is an example in which a plurality of mixing units are provided in the processing unit 103. In this configuration example, a first mixing unit 140 and a reaction unit 142 for mixing and reacting liquid A and liquid B are provided, and a second mixing unit 140a is provided on the downstream side of the reaction unit 142. In the mixing unit 140a, the third raw material liquid or the C liquid which is the reactant transported from the pump 116C is merged with the A liquid and the B liquid. The temperatures of these two mixing units 140 and 140a and one reaction unit 142 are individually controlled. The liquid C may be a reaction terminator.

  In this configuration example, the in-line yield evaluator 226 is directly connected to the outlet 202 of the second mixing unit 140a. Thereby, the yield of the result of the chemical reaction can be confirmed in real time, and can be immediately fed back to the process parameters. The in-line yield evaluator 226 includes methods such as infrared spectroscopy, near infrared spectroscopy, and ultraviolet absorption as methods that can be measured without separating the object to be measured.

  In this configuration example, a separation and extraction unit 228 that separates unnecessary substances and necessary substances from the reaction product is further provided on the downstream side of the second mixing unit 140a. As illustrated, the separation and extraction unit 228 has a Y-shaped separation channel 234. The liquid from the second mixing unit 140a is branched into two flows by the separation channel 234, one in the channel formed by the hydrophobic wall 230 that allows only the hydrophobic molecules in the material to pass through, and the other in the material It flows into the flow path formed from the hydrophilic wall surface 232 that allows only the hydrophilic molecules inside to pass therethrough. The separated substances are recovered in the recovery containers 208 and 208a via the recovery pipes 204 and 204a, respectively. As the separation / extraction unit 228, it is possible to use a membrane or a porous frit that can adsorb only a hydrophobic substance.

  FIG. 25 shows a configuration example for continuous processing by repeating mixing / reaction and separation / extraction. That is, the mixing unit 140a that processes the liquid A and the liquid B, the reaction unit 142a, and the separation / extraction unit 228a are arranged on the upstream side, and the mixing unit 140b that processes the liquid extracted from the separation / extraction unit 228a and the liquid C The part 142b and the separation / extraction part 228b are arranged on the downstream side. Unnecessary substances after the liquid A and the liquid B react are discharged from the outlet 234a of the separation and extraction unit 228a, and unnecessary substances in the second reaction to which the liquid C is added are discharged from the discharge port 234b of the separation and extraction unit 228b. Be taken out of the system. Furthermore, a mixing unit 140c that mixes the liquid extracted from the separation / extraction unit 228b and the fourth liquid D is provided. Liquid D may be a reaction terminator or other raw material solution. An in-line yield evaluator 226 may be provided on the downstream side of the mixing unit 140c.

  FIG. 26A shows a configuration in which the respective parts in FIG. 25 are stacked. The liquid flows downward. The mixing unit 140a, the reaction unit 142a, the separation / extraction unit 228a, the mixing unit 140b, the reaction unit 142b, the separation / extraction unit 228b, and the mixing unit 140c are accommodated in the temperature adjustment case 146, respectively, and further, a bolt 194, a nut 195, and a spacer 196. Are stacked at a predetermined interval. The movement of the liquid between each part is performed via the communication path 200 (refer FIG.13 (b)). The accuracy of temperature control is improved by interposing air between each part so as not to be affected by the heat of other parts by utilizing the heat insulation of air. As shown in FIG. 26B, it is preferable to cover each temperature adjustment case 146 with a heat insulating material such as a clean silicon member 236 containing bubbles.

  The fluid introduced into the fluid reaction device 2 is liquid or gas, and the substance to be recovered is liquid, gas, solid or a mixture thereof. When the introduced substance is a solid such as powder, a powder dissolver can be installed in the raw material reservoir 101. FIG. 27 is a configuration example of the raw material reservoir 101 when one of the two raw material liquids is a solution in which powder is dissolved and the other is originally liquid. The raw material powder and the solvent are introduced from the raw material inlet 242 of the powder dissolver 240. In this example, the raw material powder is dissolved by heating by the heater 244 and stirring by the stirrer 246, and the generated raw material liquid is mixed by the pump 116A from the pipe 249 drawn into the take-out port 148 by the pump 116A. It comes to send to.

It is a figure which shows typically the structure of the multi-spectral-analysis apparatus of one embodiment of this invention. It is a figure which shows the example of reaction analyzed with this apparatus. It is a figure which shows typically the structure of other embodiment of the multispectral-analysis apparatus of this invention. It is a figure which shows typically the structure of other embodiment of the multispectral-analysis apparatus of this invention. It is a figure which shows typically the structure of other embodiment of the multispectral-analysis apparatus of this invention. It is a figure which shows typically the structure of other embodiment of the multispectral-analysis apparatus of this invention. It is a figure which shows the structure of the modification of embodiment of FIG. It is a figure which shows the structure of the other modification of embodiment of FIG. (A) And (b) is a figure which shows typically the usage condition of the multispectral-analysis apparatus of one Embodiment of this invention. It is a schematic diagram which shows the whole fluid reaction apparatus. It is a perspective view which shows the structure of the whole fluid reaction apparatus of FIG. 12A is a plan view showing the overall configuration of the fluid reaction apparatus of FIG. 10, and FIG. 12B is a front view. Fig.13 (a) is a top view which shows the structure of a mixing part, FIG.13 (b) is sectional drawing. It is a figure which expands and shows the confluence | merging part of a mixing part. FIG. 15A is a plan view showing the structure of the reaction section, and FIG. 15B is a cross-sectional view. 16A is a longitudinal sectional view showing another configuration of the reaction unit, FIG. 16B is a cross-sectional view taken along line XVIII-XVIII in FIG. 16A, and FIG. 16C is still another configuration of the reaction unit. FIG. It is a perspective view which shows the structure of a temperature adjustment case. 18 (a) is a plan sectional view of the processing section, FIG. 18 (b) is a side sectional view, FIG. 18 (c) is a partially enlarged view of FIG. 18 (a), and FIG. 18 (d) is FIG. FIG. It is a figure which shows the other structure of a product storage part. FIG. 20A is a plan view showing another configuration of the merging portion, and FIG. 20B is an enlarged view of the main portion of FIG. It is a top view which shows other structure of a confluence | merging part. It is a schematic diagram which shows the other structure of a fluid reaction apparatus. It is a schematic diagram which shows the other structure of a fluid reaction apparatus. It is a schematic diagram which shows the other structure of a fluid reaction apparatus. It is a schematic diagram which shows the other structure of a fluid reaction apparatus. It is a perspective view which shows the structure of the process part of FIG. It is a schematic diagram which shows the other structure of a fluid reaction apparatus.

Explanation of symbols

1 Multispectral analyzer 2 Microreactor (fluid reaction device)
DESCRIPTION OF SYMBOLS 10 Casing 14 Flow cell 16 Internal space 18 Partition 20 Light emission part 22 Light receiving part 24 Light source part 24a-24g Light source 26 Optical fiber 28 Spectrometer 28a-28g Spectrometer 28a Ultraviolet spectrometer 28b Visible light spectrometer 28c-28e Near infrared spectrometer 28f Infrared Spectrometer 28g Far Infrared Spectrometer 30 AD Converter 32 Control Unit 34 Display 36 Storage Device 38 Alarm Device 40 Branch Flow Channel 42 Flow Control Valve 44 Open / Close Valve 46 Casing 47 Substrate 48 Channel 50 Channel Joint 52 Light-emitting Case 54 Light receiving case 56 Fixed nut 58 Mixing / reaction unit 60 Micro quenching unit 61 Water cooling jacket 62 Three-way switching valve 64 Product storage line 66 Spare tank 68 Spare line 140 Mixing unit 142 Reaction unit

Claims (8)

A multispectral analyzer for evaluating the results of organic synthesis reactions in the pharmaceutical and pharmaceutical production lines and drug development stages,
A light source unit having a plurality of light sources having different wavelengths;
A casing constituting a flow cell for circulating the liquid to be measured;
In the flow cell, a plurality of light emitting units and light receiving units adjacent to the liquid to be measured,
A spectroscopic unit having a spectroscope that individually performs spectroscopy of each wavelength obtained from the light receiving unit;
A multispectral analysis apparatus comprising: a control unit that controls and outputs spectral information of a liquid to be measured obtained by a spectroscope.   The said light source part has a light source which covers at least 2 or more wavelength range among ultraviolet light, visible light, near infrared light, infrared light, and far infrared light. Multi-spectral analyzer.   The multispectral analyzer according to claim 1, wherein a plurality of the flow cells are formed, and a light emitting unit and a light receiving unit are respectively arranged in each flow cell.   The multispectral analyzer according to any one of claims 1 to 3, wherein the casing is configured to form a plurality of flow cells therein by a partition.   The said casing is comprised so that one flow cell may be formed in an inside, The several said casing can be detachably attached on a board | substrate, The any one of Claim 1 thru | or 4 characterized by the above-mentioned. The multispectral analysis apparatus described.   6. The multispectral analysis apparatus according to claim 1, wherein a light source in a visible region to a near-infrared region is shared by a single light source and guided to different light receiving units.   The multispectral analysis apparatus according to claim 1, wherein a distance between the light emitting unit and the light receiving unit can be adjusted. A microreactor comprising the multispectral analysis apparatus according to any one of claims 1 to 7 on a downstream side of a reaction region.

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