JP2006516001A5 - - Google Patents

Claims (49)

A damping device,
A flexible housing having an outer wall and in pressure communication with the anatomy and defining a chamber therein;
An attenuation device having a vapor pressure approximately equal to the pressure in the anatomy and at least one high vapor pressure medium having a permeability of less than 1 ml / day to the outer wall at body temperature. The attenuation device of claim 1, wherein the high vapor pressure medium comprises heptafluoropropane. The attenuation device of claim 1, wherein the high vapor pressure medium comprises perfluorooctyl bromide. The attenuation device of claim 1, wherein the high vapor pressure medium comprises perfluorohexane. The attenuation device of claim 1, wherein the high vapor pressure medium comprises perfluorodecalin. The attenuation device of claim 1, wherein the high vapor pressure medium comprises tetrafluoroethane. The attenuation device of claim 1, wherein the high vapor pressure medium comprises sulfur hexafluoride. The attenuation device of claim 1, wherein the high vapor pressure medium comprises hexafluoroethane. The attenuation device of claim 1, wherein the high vapor pressure medium comprises perfluoropropane. The attenuation device of claim 1, wherein the high vapor pressure medium comprises perfluorobutane. The attenuation device of claim 1, wherein the high vapor pressure medium comprises perfluoropentane. The attenuation device of claim 1, wherein the high vapor pressure medium comprises perfluoroheptane. The attenuation device of claim 1, wherein the high vapor pressure medium comprises perfluorooctane. The attenuation device of claim 1, wherein the high vapor pressure medium comprises octafluoropropane. The attenuation device of claim 1, wherein the high vapor pressure medium comprises decafluoro-n-butane. The attenuation device of claim 1, wherein the high vapor pressure medium comprises perfluoroperhydrophenanthrene. The attenuation device of claim 1, wherein the high vapor pressure medium is liquid at body temperature. 18. The attenuation device according to claim 17, wherein the density of the high vapor pressure medium is higher than that of urine. 19. The attenuation device of claim 18, wherein the extent to which the high vapor pressure medium counteracts the buoyancy of a gas in the attenuation device is determined by the amount of the high vapor pressure medium in the attenuation device. 20. The attenuation device of claim 19, wherein the pressure on the mucosal surface of the bladder decreases when the buoyancy of the attenuation device decreases. The attenuation device of claim 1, wherein the high vapor pressure medium has a solubility of less than about 0.1 ml per ml of urine at body temperature and pressure. The attenuation device of claim 1, wherein the housing is disposed within the anatomical structure, the housing first in an introductory shape and then at least partially inflated into a second implant shape. The attenuation device of claim 1, wherein the housing is disposed within a patient's bladder. 24. The attenuation device of claim 23, wherein the medium produces an amount of gas that passes into the housing until the partial pressure of the gas in the housing matches the partial pressure in the bladder. An instrument for treating symptoms of urinary tract dysfunction, comprising a compressible attenuation device having an expansion volume in the range of about 1 cc to about 400 cc, and a valve capable of filling the attenuation device through the filling device; A first pair of complementary surfaces that prevent contraction of the attenuation device, and a second pair of complementation that resists additional filling of the attenuation device when the attenuation device is exposed to an external pressure higher than the internal pressure of the attenuation device. Having a target surface. About 80cmH ₂ 26. The device for treating symptoms of urinary tract dysfunction according to claim 25, wherein the device is compressible at a pressure of O to about 80% or less of its expanded volume. 26. The device for treating symptoms of urinary tract dysfunction according to claim 25, wherein the first pair of complementary surfaces are opposing surfaces on the flapper valve. 28. The device for treating symptoms of urinary tract dysfunction according to claim 27, wherein the flapper valve is oriented such that as the internal pressure increases, the flapper valve closing pressure increases. The instrument for treating symptoms of urinary dysfunction according to claim 4, wherein the flapper valve extends into a chamber within the attenuation device. 26. The device for treating symptoms of urinary tract dysfunction according to claim 25, wherein the closure pressure applied to the second pair of complementary surfaces increases in response to an increase in pressure in the external environment surrounding the attenuation device. A device for treating symptoms of urinary tract dysfunction, comprising a compressible attenuation device having an expansion volume in the range of about 1 cc to about 400 cc, a first complementary surface having a flow path therebetween to fill the attenuation device, and A valve having a second complementary surface, wherein the first complementary surface is configured to close the valve when the pressure external to the attenuation device is greater than the pressure within the attenuation device. The direction of the complementary surface is biased, and the second complementary surface is oriented in the direction of the first complementary surface to close the valve when the pressure in the attenuation device exceeds the pressure external to the attenuation device. A device that is biased. 32. The device for treating symptoms of urinary tract dysfunction according to claim 31, wherein the first complementary surface is disposed between the flow path and the outside of the attenuation device. 32. The device for treating symptoms of urinary tract dysfunction according to claim 31, wherein the second complementary surface is disposed between the flow path and the inside of the attenuation device. 32. Symptoms of urinary tract dysfunction according to claim 31, wherein the flow path extends in the wall of the attenuation device between a first opening to the attenuation device and a second opening to the outside of the attenuation device. Instrument to treat. 32. The device for treating symptoms of urinary tract dysfunction according to claim 31, wherein the flow path is normally collapsed in a neutral pressure state. About 80cmH ₂ 32. The device for treating symptoms of urinary tract dysfunction according to claim 31, wherein the device is compressible at a pressure of O to about 80% or less of its expanded volume. A damping device,
A flexible housing defining a chamber therein, wherein the housing is expandable from a contracted first configuration to an at least partially expanded second configuration;
A medium that is deformable to inflate the housing from a first configuration to a second configuration;
An attenuation device having an initiator for initiating deformation. 38. The attenuation device of claim 37, wherein the deformation comprises a reaction that produces a gaseous reaction product. 38. The attenuation device of claim 37, further comprising a barrier separating the chemical medium and the initiator. 40. The attenuation device of claim 39, wherein the mechanical barrier separates the chemical medium and the initiator. 40. The attenuation device of claim 39, wherein the deformation occurs in response to a barrier collapse. 40. The attenuation device of claim 39, wherein the barrier has a breakable wall defining a container containing the initiator. 40. The attenuation device of claim 39, wherein a breakable wall is included in the chamber. 40. The attenuation device of claim 39, wherein the breakable wall communicates with the chamber. 38. The attenuation device of claim 37, wherein the initiator is contained in a breakable container. 38. The attenuation device of claim 37, wherein one of the chemical medium and the initiator comprises a carbonate. 49. The attenuation device of claim 46, wherein the chemical medium or initiator comprises an acid. 38. The attenuation device of claim 37, wherein the first configuration facilitates introduction of the device into the patient's bladder, and the second configuration attenuates painful pressure changes in the bladder. The medium is a chemical medium, and the chemical medium and the initiator are initially physically separated from each other and a chemical reaction occurs when the chemical medium contacts the initiator, thereby expanding the housing. 38. The attenuation device of claim 37, wherein the attenuation device is changed from the first configuration to the second configuration.