JP2006273730A - Oxygen-containing reducing physiological saline or oxygen-containing reducing transfusion and its preparing method - Google Patents
Oxygen-containing reducing physiological saline or oxygen-containing reducing transfusion and its preparing method Download PDFInfo
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Abstract
Description
本発明は、還元性を持った生理食塩水及び輸液に関するものである。 The present invention relates to a physiological saline solution and an infusion solution having reducibility.
従来からの還元性の生理食塩水及び輸液は水素を加圧して溶解せしめるという一方向からのみの考え方であった。そのため従来からの還元性の生理食塩水及び輸液には身体が必要とする酸素がほとんど含まれていない。ちなみに従来からの水素を加圧下において溶解させた還元性生理食塩水の酸素含有量は0.00mg/リットル(東亜DKK製含有酸素濃度計で計測)であった。つまり酸素が含まれていないということであった。 Conventional reducing saline and infusion solutions were based on only one direction of pressurizing and dissolving hydrogen. For this reason, conventional reducing physiological saline and infusion contain almost no oxygen required by the body. Incidentally, the oxygen content of reductive physiological saline in which conventional hydrogen was dissolved under pressure was 0.00 mg / liter (measured with a contained oxygen concentration meter manufactured by Toa DKK). In other words, oxygen was not included.
そこで、本願の発明者は、身体が必要としている酸素を多く含有しながら、かつ多くの水素を含有し酸化還元性の非常に低い生理食塩水及び輸液を作り出す事を目的とし、種々の検討を重ねこれに成功した。 Therefore, the inventors of the present application have made various studies for the purpose of producing physiological saline and infusion solutions containing a lot of oxygen necessary for the body and containing a lot of hydrogen and having very low redox properties. Repeatedly succeeded.
前記課題を解決するために、本願の請求項1に係る発明は、酸素を0.1mg/リットル以上含有し、かつ水素濃度が0.1ppm以上の生理食塩水又は輸液であることを特徴とする。 In order to solve the above-mentioned problem, the invention according to claim 1 of the present application is a physiological saline solution or an infusion solution containing 0.1 mg / liter or more of oxygen and having a hydrogen concentration of 0.1 ppm or more. .
また、本願の請求項2に係る発明は、pHが3〜11であり、酸素を0.1mg/リットル以上含有し、かつ水素濃度が0.1ppm以上の生理食塩水又は輸液であることを特徴とする。 The invention according to claim 2 of the present application is a physiological saline or infusion solution having a pH of 3 to 11, oxygen of 0.1 mg / liter or more, and a hydrogen concentration of 0.1 ppm or more. And
本願の請求項3に係る発明は、生理食塩水又は輸液に酸素を1気圧〜1000気圧で加圧して溶解せしめ、加圧下において、または常圧に戻して得られた生理食塩水又は輸液に水素を1気圧〜1000気圧で加圧して溶解せしめ、常圧に戻して生理食塩水又は輸液を得る工程を含む生理食塩水又は輸液の製造方法であることを特徴とする。 In the invention according to claim 3 of the present application, oxygen is dissolved in physiological saline or infusion by pressurizing at 1 to 1000 atm, and hydrogen is added to physiological saline or infusion obtained under pressure or by returning to normal pressure. It is characterized by being the manufacturing method of the physiological saline or infusion including the process which pressurizes and melt | dissolves by 1 atmosphere-1000 atmosphere, and returns to a normal pressure and obtaining the physiological saline or infusion.
また、本願の請求項4に係る発明は、生理食塩水又は輸液に水素を1気圧〜1000気圧で加圧して溶解せしめ、加圧下において、または常圧に戻して得られた生理食塩水及び輸液に酸素を1気圧〜1000気圧で加圧して溶解せしめ、常圧に戻して生理食塩水又は輸液を得る工程を含む生理食塩水又は輸液の製造方法であることを特徴とする。 In addition, the invention according to claim 4 of the present application is a solution of physiological saline and infusion obtained by pressurizing and dissolving hydrogen in physiological saline or infusion at 1 atm to 1000 atm and returning to normal pressure. It is characterized by being a method for producing a physiological saline or infusion solution, which comprises a step of dissolving oxygen by pressurizing at 1 to 1000 atm, and returning to normal pressure to obtain a physiological saline solution or infusion solution.
また、本願の請求項5に係る発明は、生理食塩水及び輸液に酸素と水素を同時に1気圧〜1000気圧で加圧して溶解せしめ、常圧に戻して生理食塩水又は輸液を得る工程を含む生理食塩水又は輸液の製造方法であることを特徴とする。 In addition, the invention according to claim 5 of the present application includes the step of simultaneously dissolving oxygen and hydrogen in physiological saline and infusion solution at 1 to 1000 atm, and returning to normal pressure to obtain physiological saline or infusion solution. It is a manufacturing method of physiological saline or infusion.
従来の還元性生理食塩水は酸素の含有量が非常に希薄であり、身体が必要とする酸素量を提供することが不可能であったが、本発明による酸素含有型還元性生理食塩水は身体に必要なる酸素を持ちながら、細胞膜を透過することが可能な水素を多く含有し非常に低い酸化還元力を持つという一見相反する性質を持った生理食塩水又は輸液が提供できるようになる。 Conventional reducing saline has a very low oxygen content and cannot provide the amount of oxygen required by the body, but the oxygen-containing reducing saline according to the present invention is It is possible to provide a physiological saline solution or infusion solution which has a seemingly contradictory property of containing a large amount of hydrogen capable of permeating the cell membrane and having a very low redox power while having oxygen necessary for the body.
以下、本発明の具体例を実施例を用いて詳細に説明する。 Hereinafter, specific examples of the present invention will be described in detail using examples.
本発明は単純に水素を加圧して溶解せしめ、生理食塩水や輸液の酸化還元性を低めるという手法を採用していない。もちろん水素ガスを単純に生理食塩水や輸液の中にバブルしたとき、酸素ガスはほとんど溶存できない。つまり人間に必要な酸素が失われるので、酸素を多く含有しながら水素を多く含有し酸化還元性の低い生理食塩水及び輸液が必要となる。
酸素と水素は常温下では反応しないため、身体の中においては当然反応しない、このことを考慮すると酸素と水素を共に多く含んだ生理食塩水及び輸液を作り出すことが可能となる。
The present invention does not employ a technique of simply pressurizing and dissolving hydrogen to reduce the redox property of physiological saline or infusion. Of course, when hydrogen gas is simply bubbled into physiological saline or infusion, oxygen gas can hardly be dissolved. That is, since oxygen necessary for humans is lost, a physiological saline solution and an infusion solution containing a large amount of hydrogen while containing a large amount of oxygen and low redox properties are required.
Since oxygen and hydrogen do not react at room temperature, they naturally do not react in the body. Taking this into account, it becomes possible to create physiological saline and infusion solutions that contain both oxygen and hydrogen.
本発明の実施例においては、周知の気液接触装置を用い、市販の大塚製薬製造の生理食塩水1リットルに200mリットル/分の割合で8気圧の加圧下で酸素を溶解させ、その後、その酸素含有生理食塩水1リットルに200mリットル/分の割合で8気圧の加圧下で水素を溶解させた。 In an embodiment of the present invention, oxygen is dissolved under a pressure of 8 atm at a rate of 200 ml / min in 1 liter of physiological saline manufactured by Otsuka Pharmaceutical Co., Ltd. Hydrogen was dissolved in 1 liter of oxygen-containing physiological saline at a rate of 200 ml / min under a pressure of 8 atm.
実施例として、3.56mg/リットルの酸素含有量を持ちながら、水素濃度が1.35ppmであり−662mvの酸化還元電位を持つ理想的な還元性生理食塩水ができた。これを表1に示す。なお、酸化還元電位及び酸素量及び水素濃度の測定に関しては、共に東亜DKK製ORP計測器及び酸素量計測器及び水素濃度測定器を用いた。
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US9272000B2 (en) | 2009-04-27 | 2016-03-01 | Revalesio Corporation | Compositions and methods for treating insulin resistance and diabetes mellitus |
US8815292B2 (en) | 2009-04-27 | 2014-08-26 | Revalesio Corporation | Compositions and methods for treating insulin resistance and diabetes mellitus |
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