JP2006026368A - Blood circulating circuit - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a blood circulating circuit of a simple structure used to return a part of blood circulation to a body after taking it out into the circulating circuit and giving a certain treatment such as giving drug to the blood. <P>SOLUTION: The blood circulation circuit provides a blood removal hole 101a to take blood from outside of the circuit into the circulation circuit, a blood transmission hole 101b to transmit the blood which was circulated in the circulation circuit to the outside, a pump unit 13a for removing blood connected with the blood removal hole fluidically to take the blood into the circulation circuit forcibly through the blood removal hole, a reservoir unit 15 to pool the blood brought into the circuit by the pump for removing blood temporarily and adjust the difference of the pressures between removed blood and transmitted blood, and a pump unit 13b for transmitting blood connected to the lower part of the reservoir to transmit the blood pooled in the reservoir unit through the blood transmission hole to the outside of the circulation circuit. The circulated blood is treated with a specific drug in the circulation circuit and then it is transmitted to the outside through the blood transmission hole 101b under a certain pressure. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a blood perfusion circuit for perfusing drugs to a specific site in the body in a closed loop form. The present invention also relates to a blood perfusion circuit that can be configured by combining at least two types of circuit units in accordance with a site in the body where a treatment target exists.

  Recently, the arterial flow to the affected organ such as cancer and the venous flow from the organ are occluded using a balloon catheter, and the arterial and venous blood flow of the organ is blocked from the systemic circulatory system. In a state isolated from other organs, a high concentration of an anticancer drug is brought into contact with the organ from the artery, and the anticancer drug that has flowed out of the vein (or portal vein) is discharged out of the body and returned to the body again. A treatment method is performed in which a cycle of contacting an organ again is performed for a certain period of time. Usually, this is called an anticancer drug perfusion system, and the anticancer drug is perfused in the closed loop together with the blood flow by a blood pump for adjusting blood flow.

However, the blood perfusion circuit including the blood pump has been required to be assembled by connecting various devices in sequence every time treatment is performed, depending on the type of cancer to be treated. Therefore, it takes a lot of time to assemble the blood perfusion circuit, which is a very troublesome work.
None None

  For this reason, there is a need for a blood perfusion circuit having a very simple configuration, and a highly versatile blood perfusion circuit is desired.

  Therefore, the main object of the present invention is to use a simple blood flow which is used for taking out a part of blood flow in the body into the circuit, returning the blood to a body after performing a predetermined treatment such as drug administration. An object of the present invention is to provide a blood perfusion circuit having a simple structure.

  Another object of the present invention is to provide a highly versatile blood perfusion circuit that can be used regardless of what is being treated.

  In order to achieve the above main object, the blood perfusion circuit of the present invention is composed of a minimum number of functional units. In order to achieve the other object of the present invention, the blood perfusion circuit of the present invention is composed of a combination of at least two types of unit circuits.

  That is, according to one aspect, the blood perfusion circuit according to the present invention includes a blood removal port that introduces blood into the perfusion circuit from outside the perfusion circuit, and blood that has made a round through the perfusion circuit. A blood supply port for feeding outside the perfusion circuit, a blood removal pump unit fluidly connected to the blood removal port, and forcibly introducing blood into the perfusion circuit via the blood removal port, The blood introduced into the perfusion circuit by the blood pump is temporarily stored, the reservoir unit for adjusting the differential pressure between the blood pressure removal and the blood pressure supply, and the downstream connected to the reservoir, and stored in the reservoir A blood pumping unit for delivering the blood to the outside of the perfusion circuit through the blood delivery port, and after the prescribed drug is administered to the perfused blood in the perfusion circuit, it is substantially constant. Through the blood inlet with the pressure of It is configured to be transmitted to the outside.

  In a preferred embodiment, an air trap unit for removing air from the perfused blood is connected to the downstream side of the blood pump unit.

  In a more preferred embodiment, when the blood perfusion circuit of the present invention is used for a specific application such as cancer treatment, an oxygenator for supplying oxygen to the perfused blood is provided by the above-described blood pump. A fluid connection is made between the unit and the reservoir unit.

  As another aspect, the blood perfusion circuit described above includes the following first circuit and at least one second circuit. The first circuit is composed of a pump unit that adjusts the amount of blood to be delivered, an oxygenator that oxygenates venous blood and converts it into arterial blood, and a reservoir unit that regulates blood pressure, connected in series in order from the upstream side. The second circuit includes a pump unit that adjusts the amount of blood to be delivered and an air trap that removes air in the blood, which are connected in series from the upstream side. The reservoir unit in the first circuit is provided with an opening for administering a medicine. Here, the medicine does not necessarily need to be administered from the reservoir unit, and it is only necessary that a medicine administration means is provided in the first and / or second circuit. Furthermore, the oxygenator and / or the air trap are not necessarily required depending on the purpose of use of the blood perfusion circuit.

  As a specific aspect, a blood perfusion circuit used for cancer treatment in the pelvis includes a first circuit and at least one second circuit, and the first circuit is serially connected in order from the upstream side. It is composed of a connected pump unit that regulates the amount of blood to be delivered, an artificial lung that oxygenates venous blood to convert it into arterial blood, and a reservoir unit that regulates blood pressure, and the second circuit is serially connected in order from the upstream side. It is composed of a connected pump unit for adjusting the amount of blood to be delivered and an air trap for removing air in the blood. In this case, as a preferred embodiment, means for administering the anticancer agent is provided in the reservoir unit in the first circuit. Note that the air trap is not necessarily required.

  Furthermore, the blood perfusion circuit used for paraaortic lymph node cancer comprises one first circuit and at least two second circuits each connected in series with the first circuit, The first circuit includes a pump unit that adjusts the amount of blood to be delivered, an artificial lung that oxygenates venous blood and converts it into arterial blood, and a reservoir unit that regulates blood pressure, which are fluidly connected in series from the upstream side. Composed. Each of the second circuits includes a pump that adjusts the amount of blood to be delivered and an air trap that removes air in the blood, which are fluidly connected in series from the upstream side. The second circuits are fluidly connected to each other in parallel. In this case, as a preferred embodiment, means for administering the anticancer agent is provided in the reservoir unit in the first circuit. Note that the air trap is not necessarily required.

  According to the present invention, it is possible to obtain a blood perfusion circuit having a very simple configuration for occluding a blood flow near a specific site in the body and perfusing a drug such as an anticancer drug.

  Further, by forming the above-described blood perfusion circuit into a unit circuit to the minimum necessary number, the blood perfusion circuit necessary for treatment can be obtained quickly and reliably.

  First, a first type circuit unit constituting the first stage of the blood perfusion circuit according to the present invention will be described with reference to FIG. A second type circuit unit constituting the next stage of the blood perfusion circuit according to the present invention will be described with reference to FIG.

  1 to 4, the same reference numerals indicate functionally substantially identical devices. In FIG. 1, reference numeral 101a indicates a blood removal port which is a connection portion between a line 100 coming from a blood vessel of a patient and a line of a blood perfusion circuit according to the present invention. The blood perfusion circuit of the present invention is constituted by devices starting from the upstream connection portion 101a shown in FIG. 1 to the downstream connection portion 101b shown in FIG.

  The first circuit unit shown in FIG. 1 includes devices 11 to 15. Reference numerals 11a and 11b respectively denote a blood collection line for collecting blood from a patient and a drug injection line for injecting a drug. These injection lines are connected to the line 200 of the first circuit unit. Reference numeral 12 indicates a pyrometer for confirming the blood removal amount from the patient, and 13a indicates a blood removal pump for adjusting the blood removal amount. This pump may be of any form as long as it satisfies the specifications, but it is preferable to use two pumps connected in parallel from various viewpoints. Reference numeral 14 denotes an artificial lung for supplying oxygen to venous blood to convert it into arterial blood. As this artificial lung, for example, there is “Meracilox” (trade name) sold by Izumi Engineering and Medical Industry in Tokyo. Reference numeral 15 denotes a reservoir with a heat exchanger for adjusting the amount of blood circulating in the circuit and its temperature. As this reservoir, for example, CP-III (trade name) manufactured by Izumi Engineering & Medical Co., Ltd. is applicable. Further, an opening for drug administration is provided on the input side of the reservoir unit in the first circuit so that the drug can be administered into the reservoir unit.

  Next, for example, the operation of the first circuit will be described taking cancer treatment as an example. The patient's venous blood fed from line 100 is fed to line 200 through the blood removal port or connection 101a of the blood perfusion circuit according to the present invention. Part of the venous blood that has entered the line 200 is collected through the blood collection line 11a. If necessary, a drug is administered into the venous blood via the drug injection line 11b. The blood flow rate by the blood removal pump 13a for adjusting the blood removal amount is usually set and adjusted somewhat larger. This adjusted blood flow is confirmed by the pyro 12. Then, the adjusted blood flow is given to the artificial lung 14, where oxygen is supplied to venous blood and converted into arterial blood. The converted arterial blood is sent to a reservoir 15 with a heat exchanger. In the reservoir 15 with heat exchanger, the circulating blood volume is adjusted and the temperature of the circulating blood is adjusted. The adjusted arterial blood is sent from line 202 to the next stage circuit. The reservoir 15 is provided with a line 203 for administering an anticancer agent, a physiological saline solution or the like. In the above-described example of cancer treatment, a case where blood removal is performed from a vein and blood is fed to an artery is described as an example. However, when blood removal is performed from a vein and blood is fed to a vein, the above-described case is described. The artificial lung is no longer needed. In such a case, the downstream side of the blood removal pump 13a is directly connected to the reservoir. Therefore, venous blood circulates in the circuit as it is.

  Next, the second circuit unit connected to the above-described first circuit unit will be described with reference to FIG.

  In FIG. 2, the pump unit indicated by reference numeral 13b is a pump unit for adjusting the amount of blood flow, and the configuration and function thereof are similar to the configuration and function of the pump 13a described in FIG. It is. Reference numeral 16 indicates an air trap for removing air in the blood, and 17 indicates a transducer protection filter connected to the blood pressure measurement line 204. Reference numeral 300 indicates a blood supply and blood removal circuit on the operative field side.

  Next, the operation will be described. The arterial blood whose circulating blood volume and circulating blood temperature are adjusted by the reservoir 15 is sent to the blood feeding volume adjusting pump 13b via the line 202. The blood pumped out by the pump 13b for adjusting the blood flow is fed into the air trap 16, and if there is any air in the blood, it is removed here. Thereafter, the perfused blood is sent out of the perfusion circuit from the downstream blood supply port 101b.

  FIG. 3 is a schematic configuration diagram of a blood perfusion circuit used for treatment of pelvic cancer such as cervical cancer and rectal cancer.

  The blood perfusion circuit shown in FIG. 3 includes one first circuit and one second circuit fluidly connected in series with the first circuit. The first circuit includes a pump unit 13a that adjusts the amount of blood to be delivered and is connected in series in order from the upstream side, and an artificial lung 14 that supplies oxygen to the bloodstream to convert venous blood into arterial blood. And a reservoir unit 15 that temporarily stores perfused blood and regulates blood pressure. The second circuit is composed of a pump unit 13b1 for adjusting the amount of blood to be delivered and an air trap 16 for removing air in the perfused blood, which are fluidly connected in series from the upstream side. Since the functions of these circuits are substantially the same as those described with reference to FIGS. 1 and 2, detailed description thereof will be omitted.

  FIG. 4 is a schematic configuration diagram of a blood perfusion circuit used for treatment of para-aortic lymph node cancer.

  The blood perfusion circuit shown in FIG. 4 is composed of one first circuit and two second circuits each fluidly connected in series with the first circuit. The upstream side of the connection point 300 in the figure is the first circuit, and the downstream side is the second circuit. The second circuits are connected in parallel to each other at the connection point 300. The first circuit includes a pump unit 13a that adjusts the amount of blood to be delivered and is connected in series in order from the upstream side, and an artificial lung 14 that supplies oxygen to the bloodstream to convert venous blood into arterial blood. , And a reservoir unit 15 for adjusting blood pressure. The second circuit includes a pump unit 13 that adjusts the amount of blood to be delivered and an air trap 16 that removes air in the blood, which are connected in series in order from the upstream side.

  The first circuit has basically the same configuration as the circuit of FIG. 1, and the second circuit has basically the same configuration as the circuit of FIG. By disconnecting one second circuit downstream from the connection point 300, the blood perfusion circuit used for pelvic cancer shown in FIG. 3 is obtained. Therefore, there is a feature that a blood perfusion circuit for easily treating cancer at various sites can be configured.

  In the above description, the blood perfusion circuit has been described as including at least two circuit units, ie, a first circuit unit and a second circuit unit. It will be apparent to those skilled in the art that any circuit may be included.

  The present invention relates to an anticancer agent reflux system for effectively eliminating or reducing various cancers that have been considered difficult so far, while minimizing the influence of the anticancer agent on the human body. This is a blood perfusion circuit that is effective for medical devices and contributes greatly to the development of medical devices.

FIG. 1 is a schematic configuration diagram of a circuit unit constituting the first stage of the blood perfusion circuit according to the first embodiment of the present invention.

FIG. 2 is a schematic configuration diagram of a circuit unit constituting the next stage portion of the blood perfusion circuit according to the first embodiment of the present invention.

FIG. 3 is a schematic configuration diagram of a blood perfusion circuit according to a second embodiment of the present invention used for treatment of pelvic cancer such as cervical cancer and rectal cancer.

  FIG. 4 is a schematic configuration diagram of a blood perfusion circuit according to a third embodiment of the present invention used for the treatment of para-aortic lymph node cancer.

Explanation of symbols

101a Blood removal port 101b, 101c Blood supply port 12 Pyro 13a, 13b Blood pump 14 Artificial lung 15 Reservoir with heat exchanger 16 Air trap 17 Protection filter

Claims (8)

A blood removal port for introducing blood into the perfusion circuit from outside the perfusion circuit,
A blood supply port for delivering blood that has made a round inside the perfusion circuit to the outside of the perfusion circuit,
A blood removal pump unit that is fluidly connected to the blood removal port and forcibly introduces blood into the perfusion circuit through the blood removal port;
A reservoir unit for temporarily storing blood introduced into the perfusion circuit by the blood removal pump, and adjusting a differential pressure between blood removal pressure and blood pressure delivery;
A blood pumping unit connected downstream of the reservoir and for delivering blood stored in the reservoir to the outside of the perfusion circuit through the blood feeding port;
A blood perfusion circuit, wherein a predetermined drug is administered to the perfused blood in the perfusion circuit, and then the blood is delivered to the outside through the blood feeding port at a substantially constant pressure.   2. The blood perfusion circuit according to claim 1, further comprising an air trap unit fluidly connected to a downstream side of the blood pump unit for removing air from the perfused blood. Blood perfusion circuit.   3. The blood perfusion circuit according to claim 1, further comprising an artificial lung that is fluidly connected between the blood pumping unit and the reservoir unit and supplies oxygen to the perfused blood. A blood perfusion circuit characterized by A blood perfusion circuit for delivering a predetermined drug to the blood fed into the perfusion circuit and then delivering it to the outside of the perfusion circuit,
The perfusion circuit is composed of one first circuit and at least one second circuit fluidly connected in series with the first circuit,
The first circuit is composed of a pump unit that adjusts the amount of incoming blood and a reservoir unit that temporarily stores perfused blood and adjusts blood pressure, which are fluidly connected in series from the upstream side.
The blood perfusion circuit, wherein the second circuit is composed of a pump unit that adjusts the amount of blood to be delivered.   The blood perfusion circuit according to claim 4, wherein an air trap for removing air in the perfused blood is provided downstream of the pump unit. A blood perfusion circuit for delivering a predetermined drug to the blood fed into the perfusion circuit and then delivering it to the outside of the perfusion circuit,
The perfusion circuit comprises one first circuit and at least two second circuits, each fluidly connected in series with the first circuit,
The first circuit is composed of a pump unit that adjusts the amount of incoming blood and a reservoir unit that adjusts blood pressure, which are fluidly connected in series in order from the upstream side,
Each of the second circuits is composed of a pump unit that adjusts the amount of blood to be delivered.
The blood perfusion circuit, wherein the second circuits are fluidly connected to each other in parallel.   The blood perfusion circuit according to claim 4, wherein an air trap for removing air in the perfused blood is provided downstream of the pump unit.   The blood perfusion circuit according to any one of claims 1 to 7, wherein the drug is an anticancer drug and is administered through a drug administration port provided in the reservoir. Perfusion circuit.

Images