JP2005320260A - Conjugated nano-collagen protein - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a conjugated nano-collagen protein. <P>SOLUTION: A collagen protein derived from an animal is hydrolyzed to extract a low-molecular collagen protein having a molecular weight of ≤50 K-Dalton and a concentration of 0.05-25%, the collagen protein is mixed with 1-200 ppm nano-size photocatalytic composite silver particles, 1-500 ppm photocatalytic composite nano-iron particles and levovitamin C and the pH of the mixture is adjusted to a level within ±3 from the human skin pH 6 to obtain a liquid emulsion compatible with human skin. The decrease of the molecular weight of the collagen protein promotes the permeation of the protein into the dermal layer and the absorption of the protein into the skin and prevents the useless consumption of overused protein failed in permeating into the dermal layer. Increased skin cleaning action and microorganism suppressing action are achieved by the circulating fungicidal bacteriostatic mechanism of the nano-size photocatalytic composite silver particles, and the development of boil, acne, bacterial dermatitis, etc., is prevented to eliminate the formation of load on the skin cell by an artificial antibacterial agent. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a kind of composite nanocollagen protein, which is obtained by hydrolyzing an animal-derived collagen protein to extract a small molecule collagen protein having a molecular weight of 50 K Dalton or less and a concentration of 0.05-25%, and a 1-200 ppm nanophotocatalytic composite. Add silver particles, 1-500ppm photocatalytic composite nano iron and left-turning vitamin C, adjust the pH value to a skin value of about 6 ± 3, and make it a liquid emulsion that has affinity with human skin, and the molecular weight of collagen protein Reduces the penetration of the dermis layer to make it easier to be absorbed by the skin, does not create waste due to overuse and does not penetrate the dermis layer, and the nano-photocatalytic composite silver particle circulation sterilization sterilization mechanism further increases skin It helps to cleanse and suppress bacteria, prevent acne, etc., and stimulate the collagen protein of nano iron to repair the skin. Factor action accelerates the repair mechanism of skin cells, reduces the hypersensitivity reaction caused by collagen protein in the skin, helps cells absorb collagen protein by left-turning vitamin C, and stabilizes the composition of collagen protein in the skin, The present invention relates to a composite nanocollagen protein that provides the effect of maintaining the youthfulness and elasticity of the skin and can increase the effect of using collagen protein.

  Since ancient times, people have sought beauty methods, and collagen protein is currently attracting the most attention. Collagen protein exists in the human body and is contained in skin, skeleton, cartilage, muscle, and eyeball. Among them, 70% of the skin is composed of collagen protein. Collagen protein prevents skin aging, prevents the generation of wrinkles, and has a great effect on removing wrinkles. Therefore, in recent years, cosmetics and recreation products containing collagen protein have attracted a great deal of attention.

  Commercially available collagen protein has a large molecular weight, and when applied to the skin surface, it cannot penetrate into the dermis layer from the pores. Therefore, it is not effectively absorbed and used by skin cells, but forms waste and pore clogging. Moreover, in order to preserve collagen protein at room temperature, an artificial antibacterial agent is added to most products to form a further burden on skin cells. When the public spends money to acquire goods, it is natural to expect the greatest effect. However, while conventional collagen protein products have emphasized collagen protein, in the absence of other auxiliary ingredients, collagen protein is actually used. It cannot be absorbed by cells. There is a need for further research and improvement on this issue.

  The main object of the present invention is to provide a kind of complex nanocollagen protein which hydrolyzes animal-derived collagen protein and has a molecular weight of 50 K Dalton or less and a concentration of 0.05-25% small molecule collagen protein. Extract, add 1-200ppm nano photocatalyst composite silver particles to it, adjust the pH value to about skin skin 6 ± 3, make a liquid emulsion with affinity to human skin, reduce the molecular weight of collagen protein and reduce the dermis It is easy to penetrate into the layer and be absorbed into the skin, does not form waste due to overuse and does not penetrate into the dermis layer, and the nano photocatalyst composite silver particle circulation sterilization sterilization mechanism further improves skin cleanliness Achieves the effect of inhibiting bacteria, prevents the occurrence of acne, bacterial dermatitis, etc., and prevents the formation of burden on skin cells by artificial antibacterial agents It is assumed that was formed.

  Another object of the present invention is to provide a kind of complex nanocollagen protein, which is a small molecule collagen protein having a molecular weight of 50 K Dalton or less and a concentration of 0.05-25% by hydrolyzing animal-derived collagen protein. 1-200ppm nanophotocatalyst composite silver particles and 1-500ppm photocatalyst composite nanoiron are added to it, and the pH value is further adjusted to a skin value of about 6 ± 3, thus forming a liquid emulsion having affinity with human skin. In addition to increasing the ability of the human skin to absorb and producing a bacteria-inhibiting action, nano iron activates the skin repair action of collagen proteins, accelerates the repair mechanism of skin cells, and hypersensitivity caused by skin collagen proteins Suppose that it formed so that reaction could be reduced.

  Still another object of the present invention is to provide a kind of complex nanocollagen protein, which is a small molecule having a molecular weight of 50 K Dalton or less and a concentration of 0.05-25% by hydrolyzing an animal-derived collagen protein. Extract collagen protein, add 1-200ppm nano photocatalyst composite silver particles, and left-turning vitamin C, adjust the pH value to about 6 ± 3, and make a liquid emulsion with affinity to human skin In addition to increasing the ability of the human skin to absorb and producing a bacteria-inhibiting action, it is formed by assisting the absorption of collagen proteins by cells with left-turning vitamin C and stabilizing the composition of collagen proteins in the skin. And

The invention of claim 1 is a composite nanocollagen protein, wherein an animal-derived collagen protein is hydrolyzed to extract a small molecule collagen protein having a molecular weight of 50 K Dalton or less and a concentration of 0.05-25%, and 1-200 ppm nanophotocatalyst is extracted therefrom. The composite nanocollagen protein is characterized by adding composite silver particles and adjusting the pH value to a skin value of about 6 ± 3 to form a liquid emulsion having affinity for human skin.
The invention of claim 2 is the composite nanocollagen protein according to claim 1, wherein 1-500 ppm of photocatalytic composite nanoiron is further added to the liquid emulsion.
The invention of claim 3 is the composite nanocollagen protein according to claim 1 or claim 2, wherein left-turning vitamin C is further added to the liquid emulsion.
The invention according to claim 4 is the composite nanocollagen protein according to claim 1 or claim 2 or claim 3, wherein the liquid emulsion is added to the cosmetic rejuvenating agent and mixed to prepare an emulsion or creamy cosmetic rejuvenation product. It is a composite nanocollagenous protein characterized by

  The method of the present invention is not described in publications distributed prior to the filing of the application and is not on the market. The composite nanocollagen protein of the present invention penetrates the dermis layer and is easily absorbed by the skin, does not form waste, has the effect of cleansing the skin, repairing the skin, suppressing bacteria, and improving absorption. Its function and industrial utility value are clear and have patent requirements.

  Provided is a composite nanocollagen protein of the present invention, which hydrolyzes an animal-derived collagen protein to extract a small molecule collagen protein having a molecular weight of 50 K Dalton or less and a concentration of 0.05-25%, and is composed of nanosilver particles loaded with a photocatalyst 1-200 ppm nano photocatalyst composite silver particles, 1-500 ppm composite nano iron and left-turning vitamin C were added, and the pH value was adjusted to a skin value of about 6 ± 3, which is compatible with human skin. It becomes the liquid emulsion which has. The present invention can be further formulated into a beauty care product in the form of an emulsion or cream in addition to the beauty care medicine.

  The molecular weight of the collagen protein of the present invention is 50K Dalton or less, easily penetrates the dermis layer and is absorbed by the skin, does not cause waste due to overuse, and does not cause a situation that prevents absorption of the remaining collagen protein by the skin. . Using photocatalyst-loaded nanosilver particles, nanophotocatalyst composite silver particles are formed, and due to the strong oxidation characteristics of the photocatalyst, organic matter, bacteria, viruses, etc. can be oxidatively decomposed into water and carbon dioxide, which disappears naturally It is necessary to add antibacterial agents that do not form the problem of residual coating, odor, pathogenic bacteria generation, promote the bactericidal properties of silver particles, activate the bacteria control mechanism, and increase the burden on the skin Absent. The fungal control mechanism of the photocatalyst composite silver particles not only keeps the sterility of the formulation against bacteria, but also has the effect of keeping the skin clean by generating fungus control action on the skin surface when applied to the skin and face. It has a relaxing and extinguishing effect on acne, bacterial dermatitis, etc. Collagen protein also does not react rapidly after application, but requires a substance that stimulates its onset of action, nanoiron is considered to be a trigger for skin repair of collagen protein, accelerating the repair mechanism of skin cells, and Reduces hypersensitivity reactions caused by skin collagen proteins. Nano iron further promotes the penetration of collagen protein into the dermis layer and enhances the effect of collagen protein. In addition, it has been proved by experimental studies that left-turning vitamin C increases collagen protein in skin cells, and left-turning vitamin C is an essential requirement for collagen protein synthesis, and is a nutrient that the human body needs to ingest every day. . Therefore, in the present invention, left-turning vitamin C is added to promote cellular collagen protein absorption, stabilize the composition of the collagen protein in the skin, and maintain the youthfulness and skin elasticity. The ability to absorb is increased, and the collagen protein repair function is further activated.

It is a manufacturing flowchart of the present invention.

Claims (4)

  In the composite nanocollagen protein, animal-derived collagen protein is hydrolyzed to extract a small molecule collagen protein having a molecular weight of 50 K Dalton or less and a concentration of 0.05-25%, and 1-200 ppm nanophotocatalyst composite silver particles are added thereto, A composite nanocollagenous protein, characterized in that its pH value is adjusted to a skin value of about 6 ± 3 to form a liquid emulsion having affinity for human skin.   2. The composite nanocollagen protein according to claim 1, wherein 1-500 ppm photocatalytic composite nanoiron is further added to the liquid emulsion.   The composite nanocollagen protein according to claim 1 or 2, wherein left-turning vitamin C is further added to the liquid emulsion. The composite nanocollagen protein according to claim 1 or claim 2 or claim 3, characterized in that a liquid emulsion is added to a cosmetic rejuvenating agent and formulated into a milky or creamy cosmetic rejuvenation product. Composite nanocollagen protein.

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