JP2005261376A - Chitosan-containing assistant food - Google Patents

Chitosan-containing assistant food Download PDF

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JP2005261376A
JP2005261376A JP2004082000A JP2004082000A JP2005261376A JP 2005261376 A JP2005261376 A JP 2005261376A JP 2004082000 A JP2004082000 A JP 2004082000A JP 2004082000 A JP2004082000 A JP 2004082000A JP 2005261376 A JP2005261376 A JP 2005261376A
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chitosan
powder
water
gradually
soluble
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Hiroshi Okazaki
広志 岡▲ざき▼
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Elan Alfa Kk
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Abstract

<P>PROBLEM TO BE SOLVED: To provide a chitosan-containing assistant food exhibiting sufficient effects of the chitosan and capable of heightening the efficiency of absorption thereof in the body. <P>SOLUTION: The chitosan-containing assistant food is obtained by forming a mixed powder of a water-soluble chitosan powder and an expandable powder into a tablet, granule, capsule or powder shape. As a result, the water-soluble chitosan powder is gradually dissolved in water while the expandable powder gradually generates foam of carbon dioxide gas in the body. The aqueous solution of the chitosan powder is gradually absorbed in the body according to the gradually progressing foaming. Therefore, the chitosan dissolved in the water is accurately ingested and the absorbing efficiency of the chitosan taken into the body is extremely heightened because the aqueous solution of the chitosan is absorbed in the body according to the foam-generating phenomena over a long time. Further, the diet is carried out by the feeling of fullness caused by the foaming to cause diet effects. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

本発明は、水溶性キトサンを効果的に摂取することができるキトサン含有補助食品に関するものである。   The present invention relates to a chitosan-containing supplement that can effectively take water-soluble chitosan.

キトサンを含有した補助食品が、健康食品のひとつとして注目されている。キトサンは、天然に存在している含窒素多糖で、水溶性食物繊維の一種として知られている。その効用としては、コレステロールの改善,脂肪吸収の阻害,血圧上昇の抑制,腸内代謝の改善等の生理機能が期待されている。上記のように種々な利点のあるキトサンを、保存性,可搬性の面から水溶性のあるキトサン含有粒体の形態にすることが知られている。
特開2000−53703号公報
Supplemental foods containing chitosan are attracting attention as one of the health foods. Chitosan is a naturally-occurring nitrogen-containing polysaccharide and is known as a kind of water-soluble dietary fiber. As its utility, physiological functions such as improvement of cholesterol, inhibition of fat absorption, suppression of increase in blood pressure, improvement of intestinal metabolism and the like are expected. As described above, it is known that chitosan having various advantages is made into a form of water-soluble chitosan-containing granules from the viewpoint of storage stability and portability.
JP 2000-53703 A

しかしながら、上記キトサン含有粒体またはその水溶液を、そのまま体内に取り入れると、通常の食物類と同様な消化現象によりキトサンが摂取されるため、キトサンの本来の効用や体内への高い吸収効率が十分に確保できないという問題がある。   However, if the chitosan-containing granule or an aqueous solution thereof is taken into the body as it is, chitosan is ingested by the same digestion phenomenon as normal foods, so the original utility of chitosan and high absorption efficiency into the body are sufficient. There is a problem that it cannot be secured.

本発明は、このような問題を解決するためになされたものであり、キトサンの効用を十分に得るとともに、体内への吸収効率を高めるキトサン含有補助食品を提供することを目的とする。   The present invention has been made to solve such a problem, and an object of the present invention is to provide a chitosan-containing supplement that sufficiently obtains the effects of chitosan and increases the absorption efficiency into the body.

上記目的を達成するため、本発明のキトサン含有補助食品は、水溶性キトサン粉末と発泡性粉末を含む混合粉末を主原料とし、これらが打錠成形,顆粒状,カプセル状,粉末状のいずれかに形成されてなり、水溶性キトサン粉末と発泡性粉末が合わせて40%以上であることを要旨とする。   In order to achieve the above object, the chitosan-containing supplement of the present invention uses a mixed powder containing a water-soluble chitosan powder and an effervescent powder as a main ingredient, and these are any of tableted, granulated, capsule, and powdered forms. The gist is that the total amount of water-soluble chitosan powder and foamable powder is 40% or more.

上記キトサン含有補助食品は、胃の中で水分により溶解される。このときに、発泡性粉末が徐々に炭酸ガスの気泡を発生しながら、水溶性キトサン粉末も徐々に水中に溶解する。このような徐々に進行する発泡に伴って、キトサン粉末の水溶液も徐々に体内に吸収される。したがって、長時間に及ぶ気泡の発生現象に伴ってキトサン粉末の水溶液が体内に吸収されるので、水溶化したキトサンが確実に摂取され、体内に取入れたキトサンの吸収効率を著しく高めることができる。とくに、水溶性キトサンが粉末状の状態から打錠,顆粒状,カプセル状とされ、あるいは粉末状のままで体内に取り入れられるので、発泡とともに進行するキトサンの溶解性が良好で体内への吸収性向上にとって好適である。なお、発泡は胃から腸へかけての広い領域において持続されるので、キトサンの体内への吸収はこのような広域の消化器官において効率的に行われる。   The chitosan-containing supplement is dissolved by moisture in the stomach. At this time, the water-soluble chitosan powder gradually dissolves in water while the foamable powder gradually generates carbon dioxide bubbles. Along with such gradually progressing foaming, an aqueous solution of chitosan powder is gradually absorbed into the body. Therefore, since the aqueous solution of chitosan powder is absorbed into the body along with the generation of bubbles over a long period of time, the water-solubilized chitosan is surely ingested, and the absorption efficiency of chitosan taken into the body can be significantly increased. In particular, since water-soluble chitosan is made into a tablet, granule, capsule form from the powder state, or taken into the body in powder form, the solubility of chitosan that progresses with foaming is good and absorbable into the body It is suitable for improvement. In addition, since foaming is sustained in a wide region from the stomach to the intestine, the absorption of chitosan into the body is efficiently performed in such a wide digestive organ.

さらに、発泡性粉末が発泡することにより膨満感が持続し、そのために食欲が抑制されて節食が進行し摂取カロリーが低減して、ダイエット効果を奏する。上記膨満感は、小粒な状態で飲み込んだ補助食品が発泡することによって感じられるものなので、膨満感を明確にもよおすことができ、上記節食の進行が良好になされる。   Furthermore, a feeling of fullness is maintained by the foaming of the foamable powder, so that the appetite is suppressed, the food saving is progressed, the calorie intake is reduced, and the diet effect is produced. Since the above-mentioned fullness is felt when the supplements swallowed in a small state are foamed, the fullness can be clearly expressed, and the progress of the above-mentioned savings is made favorable.

つぎに、本発明のキトサン含有補助食品を実施するための最良の形態を説明する。   Next, the best mode for carrying out the chitosan-containing supplement of the present invention will be described.

本発明のキトサン含有補助食品の基本的構成物質は、水溶性キトサン粉末と、発泡性粉末である。   The basic constituents of the chitosan-containing supplement of the present invention are water-soluble chitosan powder and foamable powder.

まず、水溶性キトサン粉末の形成について説明する。キトサンは、カニ殻などに含まれるキチンのアセチル基を60%以上アミノ基に変えて抽出精製されたものを粉末の状態にしたものである。   First, formation of water-soluble chitosan powder will be described. Chitosan is obtained by changing the acetyl group of chitin contained in crab shells and the like to 60% or more amino group and extracting and purifying it into a powder state.

キトサンは、本来、水に対して不溶であるので、最初に水溶化処理を行う。そこで、キトサンを水に懸濁し膨潤させた後、リンゴ酸,酢酸,乳酸,クエン酸,ビタミンC等の有機酸を加えて撹拌し、キトサンに水に対する溶解性を与えて、キトサン水溶液を得る。ついで、上記キトサン水溶液を熱風中に噴霧分散させ、噴霧液滴が飛翔中に水分を乾燥させる、いわゆるスプレードライ法によって水溶性キトサン粉末を産出する。   Chitosan is inherently insoluble in water, so a water-solubilization treatment is first performed. Therefore, after chitosan is suspended in water and swollen, an organic acid such as malic acid, acetic acid, lactic acid, citric acid, and vitamin C is added and stirred to give chitosan solubility in water to obtain a chitosan aqueous solution. Next, water-soluble chitosan powder is produced by a so-called spray-drying method in which the chitosan aqueous solution is spray-dispersed in hot air, and the spray droplets dries moisture during flight.

すなわち、水溶性キトサン粉末を生成するために、キトサン水溶液をつくり、ついでこのキトサン水溶液を粉末状にする。まず、分子量50,000〜60,000で脱アセチル化度70〜80%のキトサン20gを水1000ccに懸濁し膨潤させた。その後、キトサンが懸濁された水にリンゴ酸16gを添加撹拌し、キトサンの水溶液をつくった。ついで、キトサン水溶液にデキストリン100gを添加撹拌して、微紛化前の溶液をつくった。なお、上記酸は、特にこれに限定されるものではないが、有機酸が好ましい。この有機酸として、上記リンゴ酸以外に酢酸,乳酸,クエン酸,コハク酸,マレイン酸等を使用することができる。上記酸の量は、キトサンの十分な溶解性を得るために、キトサンのグルコサミン量に対して、中和の当量以上であることが望ましい。   That is, in order to produce a water-soluble chitosan powder, a chitosan aqueous solution is prepared, and then this chitosan aqueous solution is made into powder. First, 20 g of chitosan having a molecular weight of 50,000 to 60,000 and a deacetylation degree of 70 to 80% was suspended in 1000 cc of water and swollen. Thereafter, 16 g of malic acid was added to the water in which chitosan was suspended and stirred to prepare an aqueous solution of chitosan. Next, 100 g of dextrin was added to the chitosan aqueous solution and stirred to prepare a solution before micronization. The acid is not particularly limited, but an organic acid is preferable. As the organic acid, acetic acid, lactic acid, citric acid, succinic acid, maleic acid and the like can be used in addition to the malic acid. In order to obtain sufficient solubility of chitosan, the amount of the acid is desirably equal to or more than the neutralization equivalent with respect to the amount of glucosamine in chitosan.

ついで、上記キトサン水溶液を噴霧装置を用いて、熱風中に噴霧分散させ、噴霧液滴が飛翔中に水分を乾燥させる、いわゆるスプレードライ法によって水溶性キトサン粉末を産出した。   Next, the chitosan aqueous solution was spray-dispersed in hot air using a spraying device, and water-soluble chitosan powder was produced by a so-called spray-drying method in which water droplets were dried during flight.

一方、上記発泡性粉末は、炭酸水素ナトリウム(重曹)の粉末とクエン酸の粉末を混合させることによって得られる。   On the other hand, the foamable powder is obtained by mixing a sodium hydrogencarbonate (bicarbonate) powder and a citric acid powder.

上記水溶性キトサン粉末と発泡性粉末との混合粉末を、例えば300mg/粒の錠剤に打錠成形する。一例として、水溶性キトサン粉末を150mg/粒(重量比50.0%),炭酸水素ナトリウム粉末を75mg/粒(重量比25.0%),クエン酸を37mg/粒(重量比12.3%)の割合で混合する。   The mixed powder of the water-soluble chitosan powder and the foamable powder is formed into a tablet of, for example, 300 mg / grain. As an example, water-soluble chitosan powder 150 mg / grain (weight ratio 50.0%), sodium bicarbonate powder 75 mg / grain (weight ratio 25.0%), citric acid 37 mg / grain (weight ratio 12.3%) ).

さらに、残重量部をなす成分として、澱粉を、上記水溶性キトサン粉末と発泡性粉末との粘着結合性を得るためのバインダー材として使用し、また、グリセリン脂肪酸エステル粉末と微粒二酸化ケイ素粉末を、打錠成形用の型からの離型剤として使用し、さらに、レモン香料を使用する。これらの残重量部をなす成分の粉末を、上記重量配分とされた水溶性キトサン粉末,炭酸水素ナトリウム粉末,クエン酸粉末からなる混合粉末に加えて、打錠成形前の粉末を得る。なお、レモン香料は心地よく食べることができるようにするためであり、消費者の好みに応じて他の香料におき変えることができる。   Furthermore, as a component constituting the remaining weight part, starch is used as a binder material for obtaining adhesive bonding between the water-soluble chitosan powder and the foamable powder, and glycerin fatty acid ester powder and fine silicon dioxide powder are used. It is used as a mold release agent from a mold for tableting, and a lemon flavor is further used. The powder of the component constituting these remaining parts by weight is added to the mixed powder composed of the water-soluble chitosan powder, sodium hydrogencarbonate powder, and citric acid powder, which is distributed as described above, to obtain a powder before tableting. Note that the lemon flavor can be eaten comfortably, and can be replaced with other flavors according to consumer preference.

上記打錠成形前の粉末を、打錠成形装置に供給して粒状のキトサン含有補助食品を成形する。   The powder before tableting is supplied to a tableting device to form a granular chitosan-containing supplement.

上記打錠成形以外に、打錠成形前の粉末を顆粒状に成形したもの、カプセルに封入したもの、打錠成形前の粉末をそのまま保存用袋やプラスチック容器に入れたもの等を作製した。   In addition to the above tableting molding, powders before tableting molding were formed into granules, those encapsulated in capsules, and powders before tableting molding were directly placed in storage bags or plastic containers were prepared.

上記各構成成分の配合重量は、上記の数値に限定されるものではなく、補助食品としての目的を達成するための主要成分である水溶性キトサン粉末,炭酸水素ナトリウム,クエン酸の配合比率(重量比)をつぎのとおりに設定することができる。すなわち、水溶性キトサン粉末は、少なくとも30%以上が好ましく、35%以上であればなお好ましい。さらに、30〜90%であればより好ましく、最も好ましいのは40〜85%である。炭酸水素ナトリウム粉末は、5〜40%が好ましく、クエン酸粉末は、5〜20%が好ましい。このように配合比率を調整することにより、キトサン量や発泡時間を使用者の体質や健康状態等に適合させて、消費者の多用な要望に応じた補助食品を市場に提供することができる。   The blending weight of each of the above components is not limited to the above numerical values, but the blending ratio (weight) of water-soluble chitosan powder, sodium bicarbonate, and citric acid, which are the main components for achieving the purpose as a supplement. Ratio) can be set as follows: That is, the water-soluble chitosan powder is preferably at least 30% or more, more preferably 35% or more. Furthermore, if it is 30 to 90%, it is more preferable, and the most preferable is 40 to 85%. The sodium hydrogen carbonate powder is preferably 5 to 40%, and the citric acid powder is preferably 5 to 20%. By adjusting the blending ratio in this way, the amount of chitosan and the foaming time can be adapted to the user's constitution, health condition, etc., and supplementary foods according to the consumer's various demands can be provided to the market.

本発明によるキトサン含有補助食品は、例えば、300mg/粒の重量とされた丸形状の錠剤に打錠成形される。そして、各構成成分の1粒当たりの配合重量は、つぎのとおりとした。なお、各数値は、重量比である。
水溶性キトサン粉末 80%
炭酸水素ナトリウム粉末 6%
クエン酸粉末 12%
グリセリン脂肪酸エステル 2%
上記水溶性キトサン粉末,炭酸水素ナトリウム粉末,クエン酸粉末の合計は、40〜98%が好ましく、より好ましいのは50〜95%である。
The chitosan-containing supplement according to the present invention is formed into a round tablet having a weight of, for example, 300 mg / grain. And the compounding weight per grain of each structural component was as follows. Each numerical value is a weight ratio.
80% water-soluble chitosan powder
Sodium bicarbonate powder 6%
Citric acid powder 12%
Glycerin fatty acid ester 2%
The total of the water-soluble chitosan powder, sodium hydrogen carbonate powder and citric acid powder is preferably 40 to 98%, more preferably 50 to 95%.

上記の配合重量からなる4種類の粉末を均一になるまで十分に混ぜ合わせてから、打錠成形装置に供給して、粒状の補助食品を得た。   Four types of powders having the above blending weight were sufficiently mixed until uniform, and then supplied to a tableting device to obtain a granular supplement.

上記の食品形状は丸形状の錠剤であるが、それ以外の形状として、顆粒状に成形したもの、カプセルに封入したもの、打錠成形前の粉末をそのまま保存用袋やプラスチック容器に入れたもの等を作製した。   The above food shape is a round tablet, but other shapes include granules, capsules, and pre-tablet powder in storage bags or plastic containers. Etc. were produced.

上記補助食品を複数の関係者で試食した結果、消化器官での発泡によって約2〜3時間に及ぶ膨満感が持続することが認められた。したがって、上述のように、吸収効率のよいキトサンの摂取が進行し、試食した関係者の健康状態に応じて、コレステロールの改善,脂肪吸収の阻害,血圧上昇の抑制,腸内代謝の改善等の各種の生理機能が期待できることが明らかになった。   As a result of tasting the supplementary foods with a plurality of parties, it was confirmed that a feeling of fullness extending for about 2 to 3 hours was sustained by foaming in the digestive organs. Therefore, as described above, the intake of chitosan with good absorption efficiency has progressed, and depending on the health status of the savvy parties, such as improvement of cholesterol, inhibition of fat absorption, suppression of blood pressure increase, improvement of intestinal metabolism, etc. It became clear that various physiological functions can be expected.

水溶性キトサン粉末を発泡性粉末によって、体内に効率よく吸収させて健康増進を図るとともに、膨満感によるダイエット効果が得られる新補助食品として広く消費者に歓迎されることが期待できる。   Water-soluble chitosan powder is expected to be widely welcomed by consumers as a new supplement that can be absorbed into the body efficiently by effervescent powder to promote health and provide a diet effect due to fullness.

Claims (1)

水溶性キトサン粉末と発泡性粉末を含む混合粉末を主原料とし、これらが打錠成形,顆粒状,カプセル状,粉末状のいずれかに形成されてなり、水溶性キトサン粉末と発泡性粉末が合わせて40%以上であることを特徴とするキトサン含有補助食品。   A mixed powder containing water-soluble chitosan powder and foamable powder is used as the main raw material, and these are formed into tablet, granule, capsule, or powder, and the water-soluble chitosan powder and foamable powder are combined. A supplement containing chitosan, characterized by being 40% or more.
JP2004082000A 2004-03-22 2004-03-22 Chitosan-containing assistant food Pending JP2005261376A (en)

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US8998866B2 (en) 2010-07-02 2015-04-07 Smith & Nephew Plc Provision of wound filler
US9801761B2 (en) 2010-07-02 2017-10-31 Smith & Nephew Plc Provision of wound filler
US10537657B2 (en) 2010-11-25 2020-01-21 Smith & Nephew Plc Composition I-II and products and uses thereof
US11730876B2 (en) 2010-11-25 2023-08-22 Smith & Nephew Plc Composition I-II and products and uses thereof
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