JP2005137784A - Induction heating method for animal cancer treatment and its system - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an induction heating method for animal cancer treatment and its system with a small device at a low cost. <P>SOLUTION: A magnetic field is generated by administering a complex of a polysaccharide and a magnetic body to a focus of a cancer in an animal and supplying an induction coil part 101 of an induction heating device 100 with AC from a device main body 102. The complex administered to the focus of cancer in the animal is induction-heated with the magnetic field and enables the induction heating system for animal cancer treatment to destroy cancer cells in the focus. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  The present invention relates to a cancer treatment induction heating method and a cancer treatment induction heating system used for animals other than humans.

  In recent years, the breeding environment of animals such as dogs and cats kept as pets has improved and the advancement of veterinary medicine has promoted the longevity of these animals, and among these causes of death, the proportion of those caused by cancer has increased. ing.

  However, in the field of veterinary medicine, both the medical institution and the breeder are too expensive, so the fact is that large-scale treatments such as surgical operations cannot be performed. The only treatment that can be performed is to administer anticancer drugs.

  In this regard, as one of the cancer treatment methods for humans, the fact that cancer cells or cancer tissues (hereinafter sometimes referred to as “cancer lesions”) is more susceptible to heat than normal cells is utilized. There is a treatment method called hyperthermia (hyperthermia method).

In this treatment method, a heating agent is administered to the cancerous lesion of the human body, and the heating agent is heated by applying a magnetic field to the heating agent from the outside of the human body with an induction heating device, thereby killing cancer cells. (For example, see Patent Document 1).
JP-A-9-646

  However, since the induction heating device used in the conventional thermotherapy (hyperthermia method) is large and very expensive, it is generally smaller than a human being and cannot be expensively treated. It was difficult to use to treat cancer in animals.

  Accordingly, an object of the present invention is to provide an animal cancer treatment induction heating method and an animal cancer treatment induction heating system which can treat animal cancer at low cost with a small apparatus.

  In order to solve the above problems, an administration process of administering a heating agent to a cancer lesion part of an animal, and generating an magnetic field by causing an alternating current to flow through an induction coil part installed outside the animal body, There is provided an animal cancer treatment induction heating method for animals, comprising: an induction heating step of killing cancer cells in the cancer lesion by induction heating.

  By killing animal cancer cells by such a method, it becomes possible to treat cancer in animals such as pets such as dogs and cats.

  Here, as the heating agent to be administered in the administration process, the use of a complex of polysaccharide and magnetic substance, for example, a complex of dextran and magnetic iron oxide, improves the in vivo stability, It can be evenly distributed in the lesion of cancer and can generate sufficient heat even under a relatively low magnetic field strength.

  In addition, the induction coil unit used in the induction heating process includes an induction coil and a capacitor, and this capacitor is connected in series with the induction coil to resonate with the induction coil, thereby minimizing the load impedance. Thus, the current can be maximized.

  Here, the induction coil used in the induction heating process can be one that is wound so as to extend in a direction parallel to the axis thereof, or one that is wound in a plane direction perpendicular to the axis. Can also be used.

  In addition, by setting the frequency of the alternating current flowing through the induction coil portion in the induction heating process to 129 kHz or more and 604 kHz or less, the tissue around the subcutaneous tissue or the cancer lesion portion is not excessively heated.

  Furthermore, the magnetic flux density of the magnetic field generated by the induction coil section in the induction heating process is preferably 2.6 mT or more.

  Here, an alternating current can be provided to the induction coil unit from an apparatus main body including a power source, an inverter, and a transformer.

  Here, the induction coil unit used in the induction heating process and the apparatus main body are separately formed, and the induction coil unit and the apparatus main body are connected by a flexible electric wire so that the induction coil unit is connected to the apparatus main body. Can be handled separately and is convenient.

  The present invention also includes a heating agent to be administered to a cancer lesion of an animal, and an induction heating device having an induction coil unit and a device main body that provides an alternating current to the induction coil unit, and is administered to a cancer lesion of an animal. An animal cancer treatment induction heating system for killing cancer cells in the cancer lesion portion by induction heating from outside the animal body by causing the heating agent to flow an alternating current through the induction coil to generate a magnetic field is provided.

  By killing animal cancer cells with such a system, it becomes possible to inexpensively treat cancer in animals such as pets such as dogs and cats.

  Here, as the heating agent, by using a complex of polysaccharide and magnetic substance, for example, a complex of dextran and magnetic iron oxide, the stability in the living body is good, and it is equivalent to the cancer lesion. And can generate sufficient heat even under a relatively low magnetic field strength.

  In addition, the induction coil unit includes an induction coil and a capacitor, and this capacitor is connected in series with the induction coil to resonate with the induction coil, thereby minimizing the load impedance and maximizing the current. Will be able to.

  Here, as the induction coil, a coil wound so as to extend in a direction parallel to the axis can be used, and a coil wound in a plane direction perpendicular to the axis can also be used.

  In addition, by setting the frequency of the alternating current flowing through the induction coil to 129 kHz or more and 604 kHz or less, the subcutaneous tissue or the tissue around the cancer lesion is not excessively heated.

  It is desirable that the magnetic flux density of the magnetic field generated by the induction coil unit is 2.6 mT or more.

  Furthermore, as the apparatus main body, a device provided with at least a power source, an inverter, and a transformer can be used.

  Here, the induction coil section and the apparatus main body are formed separately, and these induction coil section and the apparatus main body are connected by a flexible electric wire, so that the induction coil section is separated from the apparatus main body and separated. Can be handled easily.

  In addition, the present invention provides an induction heating apparatus for use in an animal cancer treatment induction heating system for killing cancer cells in the cancer lesion part by induction heating the heating agent administered to the cancer lesion part of the animal from outside the animal body. And the induction heating apparatus provided with an induction coil part and the apparatus main body which provides alternating current to the said induction coil part is provided.

  By heating the heating agent administered to the cancer lesion of an animal with such an induction heating device, the animal cancer can be treated at a low cost.

  In addition, the induction coil unit includes an induction coil and a capacitor, and this capacitor is connected in series with the induction coil to resonate with the induction coil, thereby minimizing the load impedance and maximizing the current. Will be able to.

  Here, as the induction coil, a coil wound so as to extend in a direction parallel to the axis can be used, or a coil wound in a direction perpendicular to the axis can be used.

  In addition, by setting the frequency of the alternating current flowing through the induction coil to 129 kHz or more and 604 kHz or less, the subcutaneous tissue or the tissue around the cancer lesion is not excessively heated.

  It is desirable that the magnetic flux density of the magnetic field generated by the induction coil unit is 2.6 mT or more.

  Furthermore, as the apparatus main body, a device provided with at least a power source, an inverter, and a transformer can be used.

  Here, the induction coil section and the apparatus main body are formed separately, and the induction coil section and the apparatus main body are connected by a flexible electric wire, so that the induction coil section is separated from the apparatus main body and separated. Can be handled easily.

  As described above, according to the present invention, it is possible to provide an animal cancer treatment induction heating method and an animal cancer treatment induction heating system capable of treating animal cancer at low cost with a small apparatus.

  FIG. 1 is a front view of an induction heating apparatus 100 used in an animal cancer treatment induction heating system according to an embodiment of the present invention.

  The induction heating device 100 includes an induction coil unit 101, a device main body 102, and an electric wire 103 that connects the induction coil unit 101 and the device main body 102.

  As shown in FIG. 2 (schematic configuration diagram of the induction coil unit 101), the induction coil unit 101 includes an induction coil 101a and a capacitor 101b. The capacitor 101b is in series with the induction coil 101a. It is connected to resonate with the induction coil 101a.

  As shown in FIG. 2, the induction coil 101a uses a solenoid type coil in which a copper wire is wound so as to extend in a direction parallel to the axis.

  The apparatus main body 102 is provided with a power switch 104 on its front panel. By turning on the power switch 104, AC electricity can be supplied to the induction coil unit 101 via an electric wire 103 described later. It has been made possible.

  The current value supplied to the induction coil unit 101 can be confirmed by the current meter 105, and the power supplied to the induction coil unit 101 can be confirmed by the power meter 106, and this power can be adjusted by the volume 107. Have been able to.

  A schematic diagram of the internal configuration of the apparatus main body 102 is shown in FIG.

  The apparatus main body 102 includes a power source 110, a noise filter 111, a rectifier 112, a boost converter 113, a step-down converter 114, an inverter 115, a transformer 116, and a control unit 117.

  The power source 110 uses a commercial power source with an AC voltage of 200 V and a frequency of 50/60 Hz. If a small animal is to be treated, it is sufficient if it can supply power of about 1 to 5 kW.

  The noise filter 111 is for preventing high-frequency current from leaking to the outside. The noise filter 111 is selected and installed in a timely range as long as such a purpose can be achieved, but is not necessarily required.

  The rectifier 112 rectifies all waveforms using a bridge circuit, but this is also for adjusting the waveforms and is not necessarily required.

  The step-up converter 113 and the step-down converter 114 use a PWM (Pulse Width Modulation) type, and these are not necessarily required.

  The inverter 115 uses a semiconductor switching element capable of high-speed switching (MOSFET in this embodiment), and supplies electricity to the induction coil section with a frequency that causes the induction coil 101a and the capacitor to resonate.

  The transformer 116 controls the voltage so that the magnetic field generated from the induction coil unit 101 is 2.6 mT or more.

  The power supply 110, the step-up converter 113, the step-down converter 114, the inverter 115, and the transformer 116 described above are controlled by the control unit 117.

  The electric wire 103 that connects the induction coil unit 101 and the apparatus main body 102 uses an LLP wire (EP rubber-insulated chlorinated polyethylene sheathed electric wire) that is relatively flexible and can secure a sufficient cross-sectional area. .

  As a heating agent to be administered into the body of an animal, a complex of polysaccharide and magnetic substance, for example, a complex of dextran and magnetic iron oxide is used.

  In the case of using dextran, those having a weight average molecular weight in the range of 1,000 to 100,000, preferably 4,000 to 10,000 are suitable from the viewpoint of colloidal stability, temperature increasing effect and the like.

  Dextran can be used unmodified. For example, dextran modified with reducing end by treatment with alkali, halogen or halous acid, or hydrolyzed after treatment with cyanide ion. It is also possible to use dextran having a modified reducing end.

  On the other hand, the magnetic substance complexed with the polysaccharide is a metal or metal compound magnetic substance that generates heat by induction heating, and includes a ferromagnetic substance and a superparamagnetic substance.

  Examples of the metal used as the magnetic material include transition metals such as iron, nickel, cobalt, and gadolinium, and iron is particularly preferable.

  Examples of the metal compound used as the magnetic material include oxides and ferrites of transition metals such as iron, nickel, and cobalt, with iron trioxide and γ-iron oxide being particularly preferable.

  It is also possible to replace a part of the bound dextran with another polysaccharide or a polysaccharide bound with a substance having a tumor affinity. For example, β-1,3-glucan can be partially introduced, or an antibody or fragment ab can be introduced, and these are useful for tumor immunity induction and targeting to tumor cells.

  The above-mentioned complex of polysaccharide and magnetic substance is prepared by adding, for example, dextran or an aqueous solution thereof to an aqueous sol of a metal magnetic substance or a metal compound magnetic substance at about 90 ° C. to about 90 ° C. under neutral to weakly acidic conditions. It can be combined by heating at a temperature between reflux temperatures for about 30 to about 120 minutes.

  Also, a metal compound magnetic material, such as magnetic iron oxide, is produced in an aqueous medium in the presence of dextran, preferably an alkali-treated modified dextran, and then between about 90 ° C. and reflux temperature under neutral to weakly acidic conditions. The composite can also be produced by heating at a temperature of about 30 to about 120 minutes.

  The complex of polysaccharide and magnetic substance prepared as described above is prepared in a shape suitable for administration into the body of an animal.

  In general, intravenous, intratumoral, intraarterial, intravesical, etc. injection or infusion (infusion) is used as the method of administration. Depending on the disease to be treated, oral administration, rectal administration, etc. It can also be administered by the method.

  In administration by injection or infusion, for example, it is usually dissolved in distilled water for injection or physiological saline at a concentration of usually 1 to 60% (w / v), preferably 5 to 20% (w / v). it can.

  Examples of additives include inorganic salts such as sodium chloride; monosaccharides such as glucose; sugar alcohols such as mannitol and sorbitol; organic acid salts such as citrate and tartrate; phosphate buffers, tris buffers, and the like. Various physiologically acceptable auxiliaries may be added as appropriate.

  On the other hand, for oral administration and rectal administration, it can be formulated into tablets, granules, capsules, capsules, powders, suppositories and the like containing dextran magnetite together with appropriate pharmaceutical auxiliaries.

  The animal cancer treatment induction heating system configured as described above is used as follows.

  A complex of polysaccharide and magnetic substance is injected directly into the cancerous lesion of an animal, or a medically useful method, for example, a method using a vascular catheter, or administration into an artery or vein reaches the tumor site Let me.

  Then, the induction heating device 100 is operated by turning on the switch 104 of the induction heating device 100.

  Then, an alternating current flows from the apparatus main body 102 to the induction coil unit 101 via the electric wire 103, and an alternating magnetic field having the central axis of the induction coil 101 a as the center of the magnetic flux is generated in the induction coil unit 101.

  By applying such an alternating magnetic field to a complex of a polysaccharide and a magnetic substance administered to the body of an animal, the complex can be heated.

  Here, when the cancer lesion is a surface cancer such as an arm or a finger, induction heating can be performed by inserting those portions into the induction coil 101a, and the cancer lesion to be treated is the induction coil 101a. If it is in a site that cannot be inserted into the body, induction heating can be performed by holding the induction coil 101a over such a site from outside the animal body.

  In the present embodiment, the solenoid type induction coil 101a as shown in FIG. 2 is used. Instead, as shown in FIG. 3 (upper perspective view of the induction coil 101c). A pan-type induction coil 101c can be used.

  As shown in FIG. 3, the pan-type induction coil 101 c is formed by winding a copper wire in a plane direction perpendicular to the axis.

  Each experimental example using the induction heating apparatus 100 described in the embodiment described above is shown below.

  First, in the following experiment, in order to obtain the same results as when the complex of polysaccharide and magnetic substance administered to the animal body is actually heated, a pseudo-living body (agar In order to confirm whether it is necessary to interpose the phantom) between the composite and the induction coil 101a, the following Experimental Examples 1 to 4 were performed.

  [Experimental Example 1] As coordinates indicating the relative position with respect to the induction coil 101a, the central axis direction of the induction coil 101a is Z, the radial direction of the induction coil 101a orthogonal to the central axis direction is X, and orthogonal to both the X and Z directions. Let Y be the radial direction of the induction coil 101a, and the intersection of the X, Y, and Z axes is on the central axis of the induction coil 101a and located at one end of the induction coil 101a.

  In the following description, the units of the values of the coordinates (X, Y, Z) are all mm, and for the coordinate values of X, Y, Z, the direction toward the outside of the induction coil 101a is the positive direction. .

  The inside of the induction coil 101a is filled with a cylindrical agar phantom, and dextran is used as a polysaccharide in the position of the coordinate value (X, Y, Z) = (0, 0, 0) in the agar phantom. A composite (concentration = 28 Fe mg / mL) filled with a balloon made of magnetic iron oxide as a magnetic material (hereinafter, dextran magnetite) is inserted, and the resonance frequency f between the induction coil 101a and the capacitor is Dextran magnetite was induction-heated using an induction heating device 100 in which f = 299 kHz and the magnetic flux density B generated in the induction coil 101a was B = 5.2 mT.

  As a result, the temperature of the dextran magnetite during the induction heating time was the content indicated by the solid line in the graph of FIG.

  [Experimental Example 2] In the apparatus used in Experimental Example 1, the agar phantom was removed from the inside of the induction coil 101a and the other conditions were exactly the same as in Experimental Example 1, and the result of induction heating of dextran magnetite was as follows. The content indicated by the dotted line in the graph of FIG.

  [Experimental Example 3] Obtained as a result of induction heating of dextran magnetite using the induction heating apparatus 100 in which the resonance frequency f of the induction coil 101a and the capacitor is f = 418 kHz and other conditions being exactly the same as in Experimental Example 1. The temperature of the dextran magnetite in the obtained induction heating time was the content shown by the solid line in the graph of FIG.

  [Experimental Example 4] In the apparatus used in Experimental Example 3, the agar phantom was removed from the inside of the induction coil 101a, and the other conditions were exactly the same as in Experimental Example 3, resulting in induction heating of dextran magnetite. The temperature of the dextran magnetite during the induction heating time was the content indicated by the dotted line in the graph of FIG.

  As described above, substantially the same result was obtained in Experimental Example 1 and Experimental Example 2, and substantially the same result was obtained in Experimental Example 3 and Experimental Example 4 performed by changing the resonance frequency f. Therefore, in the following experiment, it is considered that it was confirmed that it is not necessary to interpose a pseudo living body (agar phantom) between dextran magnetite and the induction coil 101a.

  Next, in order to confirm how the positional relationship of the dextran magnetite with respect to the induction coil 101a affects the temperature characteristics of the dextran magnetite, the following Experimental Examples 5 to 8 were performed.

  [Experimental Example 5] The dextran magnetite filled in the balloon is arranged at the coordinate value (X, Y, Z) = (0, 15, 0), and the other conditions are exactly the same as in Experimental Example 2. The temperature characteristics of dextran magnetite in the induction heating time obtained as a result of induction heating of magnetite were the contents indicated by the short dotted line in the graph of FIG.

  [Experimental Example 6] Dextran magnetite filled in a balloon is arranged at coordinate values (X, Y, Z) = (0, 30, 0), and other conditions are made exactly the same as in Experimental Example 2, and dextran is then used. The temperature characteristics of dextran magnetite in the induction heating time obtained as a result of induction heating of magnetite were the contents indicated by the long dotted line in the graph of FIG.

  The solid line in the graph of FIG. 7 is the temperature characteristic of dextran magnetite in the induction heating time obtained in Experimental Example 2.

  Here, in Experimental Example 5 and Experimental Example 6 described above, the position of the dextran magnetite in Experimental Example 2 was changed only in the Y-axis direction, but the Y-axis and X-axis are the same in the radial direction of the induction coil 101a. Therefore, even if only the position of dextran magnetite in the X-axis direction is changed, it is considered that the same result as in Experimental Example 5 and Experimental Example 6 can be obtained.

  Therefore, even if the position of dextran magnetite changes in the radial direction of the induction coil 101a from the results of the above Experimental Example 2, Experimental Example 5, and Experimental Example 6, it is within the range of 0 to 30 mm from the central axis of the induction coil 101a. It was found that there was almost no effect on the temperature characteristics of dextran magnetite.

  [Experimental Example 7] The arrangement of the dextran magnetite filled in the balloon was set to the position of coordinate value (X, Y, Z) = (0, 0, 30), and other conditions were made exactly the same as in Experimental Example 4. The temperature rise characteristic of dextran magnetite with respect to induction heating time obtained as a result of induction heating of dextran magnetite was the content indicated by the short dotted line in the graph of FIG.

  [Experimental Example 8] The arrangement of the dextran magnetite filled in the balloon was set to the position of coordinate value (X, Y, Z) = (0, 0, 45), and other conditions were made exactly the same as in Experimental Example 4 and others. Thus, the temperature rise characteristic of dextran magnetite with respect to induction heating time obtained as a result of induction heating of dextran magnetite was the content indicated by the long dotted line in the graph of FIG.

  Note that the solid line in the graph of FIG. 8 is the temperature characteristic of dextran magnetite in the induction heating time obtained in Experimental Example 4.

  From the results of Experimental Example 4, Experimental Example 7, and Experimental Example 8, when the position of the dextran magnetite changes in the central axis direction of the induction coil 101a, the temperature rise characteristic of the dextran magnetite increases as the distance from the induction coil 101a increases. Was found to decrease relatively.

  However, it is considered that dextran magnetite can be heated by induction heating at least in the range of coordinate values (X, Y, Z) = (0, 0, 0) to (0, 0, 45).

  Next, in order to confirm how the magnetic flux density generated in the induction coil 101a affects the temperature characteristics of dextran magnetite, the following Experimental Examples 9 to 14 were performed.

  [Experimental Example 9] Induction heating obtained as a result of induction heating of dextran magnetite with the magnetic flux density B generated in the induction coil 101a being B = 1.3 mT and other conditions being exactly the same as in Experimental Example 2. The temperature characteristics of dextran magnetite over time were the contents indicated by the short dotted line in the graph of FIG.

  [Experimental Example 10] Induction heating obtained as a result of induction heating of dextran magnetite with the magnetic flux density B generated in the induction coil 101a being B = 2.6 mT and other conditions being exactly the same as in Experimental Example 2. The temperature characteristics of dextran magnetite over time were the contents indicated by the long dotted line in the graph of FIG.

  [Experimental Example 11] Induction heating obtained as a result of induction heating of dextran magnetite with the magnetic flux density B generated in the induction coil 101a being B = 3.9 mT and other conditions being exactly the same as in Experimental Example 2. The temperature characteristics of dextran magnetite over time were the contents indicated by the alternate long and short dash line in the graph of FIG.

  The solid line in the graph of FIG. 9 is the temperature characteristic of dextran magnetite in the induction heating time obtained in Experimental Example 2.

  [Experimental Example 12] Inductive heating obtained as a result of induction heating of dextran magnetite with the magnetic flux density B generated in the induction coil 101a being B = 1.3 mT and other conditions being exactly the same as in Experimental Example 4. The temperature characteristics of dextran magnetite over time were the contents indicated by the short dotted line in the graph of FIG.

  [Experimental Example 13] Induction heating obtained as a result of induction heating of dextran magnetite with the magnetic flux density B generated in the induction coil 101a being B = 2.6 mT and other conditions being exactly the same as in Experimental Example 4. The temperature characteristics of dextran magnetite over time were the contents indicated by the long dotted line in the graph of FIG.

  [Experimental Example 14] Induction heating obtained as a result of induction heating of dextran magnetite with the magnetic flux density B generated in the induction coil 101a being B = 3.9 mT and other conditions being exactly the same as in Experimental Example 4. The temperature characteristics of dextran magnetite over time were the contents indicated by the alternate long and short dash line in the graph of FIG.

  Note that the solid line in the graph of FIG. 10 is the temperature characteristic of dextran magnetite in the induction heating time obtained in Experimental Example 4.

  From the results of Experimental Example 2, Experimental Example 4, and Experimental Examples 9 to 14, when the magnetic field intensity B generated in the induction coil 101a changes regardless of the resonance frequency f of the capacitor and the induction coil 101a, the magnetic field It was found that the lower the strength B, the lower the slope of the dextran magnetite temperature rise.

  However, except for at least the case where the magnetic field strength B is set to B = 1.3 mT, the tendency of dextran magnetite to rise in temperature is clearly seen. Therefore, even if the magnetic field strength B generated in the induction coil 101a changes, at least the magnetic field strength It was found that when the intensity B is B = 2.6 mT or more, the dextran magnetite is induction-heated regardless of the resonance frequency f.

  Next, in order to confirm how the resonance frequency f of the capacitor and the induction coil 101a affects the temperature rise characteristics of dextran magnetite, the following Experimental Examples 15 to 17 were performed.

  [Experimental Example 15] Obtained as a result of induction heating of dextran magnetite using the induction heating apparatus 100 having a resonance frequency f of f = 129 kHz and the other conditions being exactly the same as those of Experimental Example 1 and Experimental Example 3. The temperature characteristics of dextran magnetite during the induction heating time were as shown by the solid line in the graph of FIG.

  [Experimental Example 16] Obtained as a result of induction heating of dextran magnetite using the induction heating apparatus 100 having a resonance frequency f of f = 511 kHz and the other conditions being exactly the same as those of Experimental Example 1 and Experimental Example 3. The temperature characteristics of dextran magnetite during the induction heating time were the contents indicated by the alternate long and short dash line in the graph of FIG.

  [Experimental Example 17] Obtained as a result of induction heating of dextran magnetite using the induction heating apparatus 100 having a resonance frequency f of f = 604 kHz and the other conditions being exactly the same as those of Experimental Example 1 and Experimental Example 3. The temperature characteristics of dextran magnetite during the induction heating time were the contents indicated by the two-dot chain line in the graph of FIG.

  In addition, the short dotted line in the graph of FIG. 11 is a temperature characteristic of the dextran magnetite in the induction heating time obtained by Experimental Example 1, and the long dotted line in the graph of FIG. 11 is the induction heating obtained by Experimental Example 3. It is a temperature characteristic of dextran magnetite in time.

  From the results of Experimental Example 1, Experimental Example 3, and Experimental Example 15 to Experimental Example 17, when the resonance frequency f changes, the lower the resonance frequency f, the more the slope of the dextran magnetite temperature rise is relatively. It turns out that it falls.

  However, it has been found that the temperature of the dextran magnetite rises at least when the resonance frequency f is in the range of f = 129 to 604 kHz.

  Next, in order to confirm how the shape of the induction coil 101a affects the temperature rise characteristics of dextran magnetite, the following Experimental Examples 18 to 25 were performed.

  In the following Experimental Examples 18 to 25, the pan-type induction coil 101c shown in FIG. 3 was used.

  [Experimental Example 18] Dextran magnetite (concentration = 28 Fe) filled in a balloon at the position of coordinate values (X, Y, Z) = (0, 0, 15) by changing the induction coil 101 a to a pan-type induction coil 101 c. mg / mL), and the induction heating device 100 in which the resonance frequency f of the capacitor and the induction coil 101c is f = 266 kHz, and the magnetic flux density B generated in the induction coil 101c is B = 5.2 mT is used. Induction heating was applied.

  The temperature characteristics of the dextran magnetite obtained as a result of the induction heating time were as shown by the solid line in the graph of FIG.

  [Experimental Example 19] The arrangement of the dextran magnetite filled in the balloon was set to the position of coordinate value (X, Y, Z) = (0, 0, 30), and other conditions were made exactly the same as in Experimental Example 18. The temperature characteristics of dextran magnetite in the induction heating time obtained as a result of induction heating of dextran magnetite were the contents indicated by the short dotted line in the graph of FIG.

  [Experimental Example 20] The arrangement of dextran magnetite filled in the balloon was set to the position of coordinate value (X, Y, Z) = (0, 0, 45), and other conditions were exactly the same as in Experimental Example 18. The temperature characteristics of dextran magnetite in the induction heating time obtained as a result of induction heating of dextran magnetite were the contents indicated by the long dotted line in the graph of FIG.

  [Experimental Example 21] The arrangement of dextran magnetite filled in the balloon was set to the position of coordinate value (X, Y, Z) = (0, 0, 60), and other conditions were made exactly the same as in Experimental Example 18. The temperature characteristics of dextran magnetite in the induction heating time obtained as a result of induction heating of dextran magnetite were the contents indicated by the alternate long and short dash line in the graph of FIG.

  From the results of the above experimental examples 18 to 21, when the position of the dextran magnetite is changed in the central axis direction of the induction coil 101c, the inclination of the temperature increase of the dextran magnetite is relatively decreased as the distance from the induction coil 101c is increased. I understood.

  However, it was found that dextran magnetite can be heated at least in the range of coordinate values (X, Y, Z) = (0, 0, 15) to (0, 0, 60).

  [Experimental Example 22] Dextran magnetite (concentration = 28 Fe) filled in a balloon at a position of coordinate values (X, Y, Z) = (0, 0, 15) by changing the induction coil 101 a to a pan-type induction coil 101 c. mg / mL), and the induction heating device 100 in which the resonance frequency f of the capacitor and the induction coil 101c is f = 378 kHz, and the magnetic flux density B generated in the induction coil 101c is B = 5.2 mT is used. Induction heating was applied.

  The temperature characteristics of the dextran magnetite obtained as a result of the induction heating time were as shown by the solid line in the graph of FIG.

  [Experimental Example 23] The arrangement of dextran magnetite filled in the balloon is set to the position of coordinate value (X, Y, Z) = (0, 15, 15), and other conditions are made exactly the same as in Experimental Example 22. The temperature characteristics of dextran magnetite in the induction heating time obtained as a result of induction heating of dextran magnetite were the contents indicated by the short dotted line in the graph of FIG.

  [Experimental Example 24] The arrangement of dextran magnetite filled in the balloon was set to the position of coordinate value (X, Y, Z) = (0, 30, 15), and other conditions were made exactly the same as in Experimental Example 22. The temperature characteristics of dextran magnetite in the induction heating time obtained as a result of induction heating of dextran magnetite were the contents indicated by the long dotted line in the graph of FIG.

  [Experiment 25] The arrangement of the dextran magnetite filled in the balloon is set to the position of the coordinate value (X, Y, Z) = (0, 45, 15), and other conditions are exactly the same as in Experiment 22. The temperature characteristics of dextran magnetite in the induction heating time obtained as a result of induction heating of dextran magnetite were the contents indicated by the alternate long and short dash line in the graph of FIG.

  In the above experimental examples 22 to 25, only the position of dextran magnetite in the Y-axis direction was changed. However, since the Y-axis and the X-axis are the same in the radial direction of the induction coil 101c, X Even if only the position of the dextran magnetite in the axial direction is changed, it is considered that the same results as in Experimental Examples 22 to 25 are obtained.

  Therefore, from the results of the above experimental examples 22 to 25, when the position of the dextran magnetite changes in the radial direction of the induction coil 101c, the temperature rise characteristic of the dextran magnetite is relatively increased as the distance from the central axis of the induction coil 101c increases. It turned out to be reduced.

  However, it was found that dextran magnetite can be heated at least in the range of coordinate values (X, Y, Z) = (0, 0, 15) to (0, 45, 15).

  FIG. 14 shows detailed specifications that differ for each resonance frequency f of the solenoid type induction coil 101a shown in FIG. 2 used in the above experimental example. Similarly, FIG. 15 shows the solenoid shown in FIG. The detailed specifications which differ for every resonance frequency f of the induction heating apparatus 100 which has the type | mold induction coil 101a are shown.

  FIG. 16 shows the detailed specifications of the pan-type induction coil 101c shown in FIG. 11 used in the above experimental example when the resonance frequency f is f = 378 kHz. Similarly, FIG. The detailed specification of the induction heating apparatus 100 which has the pan-shaped induction coil 101c shown in FIG. 11 is shown.

  Note that the numerical values shown in each of FIGS. 14 to 17 are effective values.

The front view of the induction heating apparatus 100 used for the cancer treatment induction heating system for animals which concerns on one Embodiment. The schematic block diagram of the induction coil part 101. FIG. The upper perspective view of the induction coil 101c. FIG. 3 is a schematic diagram of an internal configuration of the apparatus main body. The graph showing the temperature of the dextran magnetite in the induction heating time of Experimental example 1 and 2. FIG. The graph showing the temperature of the dextran magnetite in the induction heating time of Experimental example 3 and 4. The graph showing the temperature of the dextran magnetite in the induction heating time of Experimental example 5 and 6. The graph showing the temperature of the dextran magnetite in the induction heating time of Experimental example 7 and 8. The graph showing the temperature of the dextran magnetite in the induction heating time of Experimental example 9,10,11. The graph showing the temperature of the dextran magnetite in the induction heating time of Experimental example 12, 13 and 14. FIG. The graph showing the temperature of the dextran magnetite in the induction heating time of Experimental example 15, 16, and 17. FIG. The graph showing the temperature of the dextran magnetite in the induction heating time of Experimental example 18, 19, 20, and 21. FIG. The graph showing the temperature of the dextran magnetite in the induction heating time of Experimental example 22, 23, 24, and 25. FIG. Explanatory drawing which shows the detailed specification of the induction coil 101a. Explanatory drawing which shows the detailed specification of the induction heating apparatus 100. FIG. Explanatory drawing which shows the detailed specification of the induction coil 101c. Explanatory drawing which shows the detailed specification of the induction heating apparatus 100. FIG.

Explanation of symbols

DESCRIPTION OF SYMBOLS 100 Induction heating apparatus 101 Induction coil part 102 Apparatus main body 103 Electric wire 110 Power supply 111 Noise filter 112 Rectifier 113 Boost converter 114 Buck converter 115 Inverter 116 Transformer 117 Control part

Claims (26)

An administration process in which a heating agent is administered to a cancer lesion of an animal;
An induction heating process of inducing and heating the heating agent to kill cancer cells in the cancer lesion by causing an alternating current to flow through an induction coil section installed outside the animal body to generate a magnetic field. Cancer treatment induction heating method.   The method for inducing cancer treatment induction for animals according to claim 1, wherein the heating agent administered in the administration process is a complex of a polysaccharide and a magnetic substance.   The induction coil unit used in the induction heating process includes an induction coil and a capacitor, and the capacitor is connected in series to the induction coil and resonates with the induction coil. The animal cancer treatment induction heating method according to claim 1 or 2.   The induction heating method for animal cancer treatment according to claim 3, wherein the induction coil used in the induction heating process is wound so as to extend in a direction parallel to an axis thereof.   The method for induction heating of cancer treatment for animals according to claim 3, wherein the induction coil used in the induction heating process is wound in a plane direction perpendicular to the axis thereof.   The method for induction heating of cancer treatment for animals according to any one of claims 1 to 5, wherein the frequency of the alternating current flowing through the induction coil section in the induction heating process is 129 kHz or more and 604 kHz or less.   The animal cancer treatment induction heating method according to claim 1, wherein a magnetic flux density of a magnetic field generated by the induction coil unit in the induction heating process is 2.6 mT or more.   The animal cancer treatment induction according to any one of claims 1 to 7, wherein an alternating current is passed through the induction coil unit from a device main body including a power source, an inverter, and a transformer. Heating method.   The induction coil unit used in the induction heating process and the device main body are formed separately, and the induction coil unit and the device main body are connected by a flexible electric wire. The animal cancer treatment induction heating method according to claim 8. A heating agent to be administered to a cancer lesion of an animal;
An induction heating device having an induction coil unit and a device main body that provides alternating current to the induction coil unit,
The cancer treatment for animals which kills the cancer cell of the said cancer lesion part by induction-heating the said heating agent administered to the cancer lesion part of an animal from the body of the said animal by carrying out alternating current to the said induction coil part, and generating a magnetic field. Induction heating system.   The animal cancer treatment induction heating system according to claim 10, wherein the heating agent is a complex of a polysaccharide and a magnetic substance.   The induction coil unit includes an induction coil and a capacitor, and the capacitor is connected in series to the induction coil and resonates with the induction coil. Animal cancer treatment induction heating system for animals.   13. The animal cancer treatment induction heating system according to claim 12, wherein the induction coil is wound so as to extend in a direction parallel to the axis.   13. The animal cancer treatment induction heating system according to claim 12, wherein the induction coil is wound in a plane direction perpendicular to the axis.   The animal cancer treatment induction heating system according to any one of claims 10 to 14, wherein the frequency of the alternating current flowing through the induction coil section is 129 kHz or more and 604 kHz or less.   16. The animal cancer treatment induction heating system according to claim 10, wherein a magnetic flux density of a magnetic field generated by the induction coil unit is 2.6 mT or more.   The animal treatment induction heating system for animals according to any one of claims 10 to 16, wherein the apparatus main body includes at least a power source, an inverter, and a transformer.   18. The induction coil unit and the apparatus main body are formed separately, and the induction coil unit and the apparatus main body are connected by a flexible electric wire. The animal cancer treatment induction heating system according to claim 1. An induction heating apparatus used in an animal cancer treatment induction heating system for killing cancer cells in the cancer lesion by inducing and heating the heating agent administered to the cancer lesion of an animal from outside the body of the animal,
An induction heating apparatus comprising: an induction coil unit; and a device main body that provides alternating current to the induction coil unit.   The induction according to claim 19, wherein the induction coil unit includes an induction coil and a capacitor, and the capacitor is connected in series to the induction coil and resonates with the induction coil. Heating device.   The induction heating apparatus according to claim 20, wherein the induction coil is wound so as to extend in a direction parallel to the axis.   The induction heating apparatus according to claim 20, wherein the induction coil is wound in a plane direction perpendicular to the axis.   The induction heating device according to any one of claims 19 to 22, wherein the frequency of the alternating current flowing through the induction coil section is 129 kHz or more and 604 kHz or less.   The induction heating device according to any one of claims 19 to 23, wherein a magnetic flux density of a magnetic field generated by the induction coil unit is 2.6 mT or more.   The induction heating apparatus according to any one of claims 19 to 24, wherein the apparatus main body includes at least a power source, an inverter, and a transformer. 26. The induction coil unit and the apparatus main body are formed separately, and the induction coil unit and the apparatus main body are connected by a flexible electric wire. The induction heating apparatus according to claim 1.

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