JP2004325462A - Chemical analyzer and chemical analysis system - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a small-sized, portable, and easily maintained chemical analyzer, dispensing with piping for cleaning liquid, waste liquid, etc. for a user to arbitrarily set a reagent corresponding to an analysis item. <P>SOLUTION: This chemical analyzer is for mixing the reagent with a specimen liquid, reacting an objective constituent in the specimen liquid with the reagent, and measuring the concentration of the constituent. This analyzer is equipped with a holding carrier equipped with a domain or a plurality of regions for temporarily holding a liquid, a holding-carrier locking means for temporarily locking the holding carrier, a specimen apportioning means for successively apportioning the same specimen liquid among a plurality of different positions on the holding carrier, a reagent discharge means for successively discharging reagents different in kind to each specimen liquid holding region of the holding carrier, and a position adjusting means for giving conformability by adjusting relative positions between the discharge means and a specimen liquid holding position. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  The present invention relates to a chemical analyzer for analyzing components such as biological fluids such as blood and urine, and water, and particularly to an emergency test in an operating room or an emergency room, a test at home or at a bedside, or a general clinic. The present invention relates to a chemical analyzer suitable for so-called POC (Point-of-Care) testing, such as rapid inspection near a patient.

  As a conventional chemical analyzer for biological fluid such as blood, there is a chemical analyzer described in US Pat. No. 4,451,433. This device comprises a colorimetric measurement unit for analyzing and quantifying proteins, enzymes, components in urine, and the like in blood, and an ion analysis unit for analyzing ions in blood. This device has a processing speed of hundreds of tests an hour, and a processing speed of 9000 tests or more for a large-sized device. In particular, in the colorimetric measurement section, in order to increase the processing speed, a number of reaction vessels are provided on the circumference of the turntable on the top of the main body of the chemical analyzer, and blood samples are sequentially mixed, reacted, and measured by overlapping processing. System.

  The main components of this device are an automatic sample and reagent supply mechanism for supplying the sample solution and reagent to the reaction container, a holding unit for holding dozens of types of reagent containers, An automatic stirring mechanism for stirring blood samples and reagents, a measuring instrument for measuring the physical properties of the blood sample during or after the reaction, and aspirating and discharging the blood sample after the measurement and washing the reaction container Automatic cleaning mechanism to reduce cross-contamination between samples due to carryover of blood sample and contamination between different reagents, automatic cleaning mechanism for reagent supply mechanism, and control unit to control these operations Etc.

  There are several dozen types of colorimetric measurement items to be analyzed, and at least about ten types of items are analyzed with respect to one specimen in a normal inspection item. In order to handle these items with a single device, a mechanism called a reagent pipetting mechanism is provided as a reagent supply mechanism, which selects a reagent from a plurality of reagent containers and sequentially supplies a predetermined amount of the reagent to the reaction container. I have. The reagent pipetting mechanism mainly includes a nozzle for sucking and holding a reagent therein, a mechanism for moving the nozzle three-dimensionally, and a suction / discharge control pump for sucking and discharging a sample into the nozzle.

  Further, as a conventional technique for POC testing, there is a blood analyzer described in Japanese Patent Publication No. 9-504732. The analyzer consists of a photodetector, a main unit that performs control, signal processing, signal input / output, etc., and a disposable centrifugal reagent rotor that automatically introduces a sample liquid and adjusts pretreatment with reagents Department. First, blood is injected as a specimen into the inlet located at the center of the disk. After setting the rotor in the main body, the rotor is driven to rotate by the operation of the main body. At this time, a serum component is separated by a centrifugal action, and a predetermined amount of serum is quantified and mixed with a diluent previously charged in the rotor. By further stopping and rotating the diluent, the diluent is introduced into twelve reaction cells provided around the diluent. In this reaction cell, a dry reagent and a stirring ball corresponding to different measurement items are put, whereby the reagent and the diluent are mixed to start a predetermined reaction. After about 12 minutes, the absorbance in the surrounding cell is measured by a light detector built in the main body. Several types of reagent rotors are prepared according to the combination of the measurement items.

U.S. Pat. No. 4,451,433

Tokio Hei 9-504732

  The analyzers used for POC testing are small and portable, can obtain analysis results quickly, are easy to handle, require little maintenance to enable analysis at any time, When used for a routine examination near a patient, such as a hospital, it is necessary to have sufficient cost competitiveness as compared with the case of requesting an examination center for a fee.

  Therefore, when the above-mentioned conventional analyzer is applied to POC testing, there are the following problems.

  First, in the first prior art, since the apparatus is large, it is difficult to install the apparatus in an emergency room or operating room where space is generally limited. In addition, since it is fixedly installed with a washing liquid or waste liquid pipe, it cannot be moved or carried to a home patient or a bedside. In addition, when used in clinics and the like, the running costs including equipment costs and maintenance are large, which is not economical.

  Next, the second prior art can be installed in an operating room or the like because of its small size as compared with the large chemical analyzer of the first prior art. Further, since all the portions to which the sample liquid communicates are disposable, a supply pipe for the cleaning liquid is not required. Therefore, it is relatively easy to carry and has good maintainability. Further, there is a feature that the device cost is low. By the way, the reagent rotor is filled with reagents for measurement items determined in advance by the manufacturer, and in many cases, unnecessary measurement items are actually measured simultaneously. Therefore, as described below, there is a problem with respect to POC testing in terms of speed and cost.

  First of all, even if there is a combination of items to be measured according to symptoms in an emergency test, if the reagent of the combination is not contained in the reagent rotor, several reagent rotors are replaced, the reagent rotors are replaced, and analysis is performed sequentially. Must be done, resulting in extra time. This is a major problem in emergency tests, which require quick derivation of test results.

  Second, since the analysis items are fixed in advance, even if items that do not need to be analyzed are analyzed or unnecessary analysis is not performed, the reagent rotor once used for another measurement is discarded. For this reason, an extra cost is required, which is inferior in economics to the cost of requesting a cost competitive inspection center. At present, it is important to further reduce examination costs due to reduction of medical expenses, and this is a bottleneck for dissemination in homes, bedsides, clinics and the like.

  In view of the above, an object of the present invention is to provide a chemical analyzer that can be arbitrarily set by a user according to an analysis item and that is easy to maintain, is small, portable, and does not require piping such as washing liquid and waste liquid. is there.

  The above object is achieved by one inlet for introducing a sample liquid to be tested on one substrate, separating the introduced sample liquid into a plurality of flow paths, and analyzing the measured liquid by a measuring unit provided in the flow path. The analysis cassette is configured to send the measured sample liquid to a plurality of reaction sections provided at the end portions of the respective flow paths in accordance with the test items. The configuration is such that the reagent is supplied, the reagent is mixed with the sample liquid, and then the analysis is performed.

  In addition, a filter is provided in the introduction portion of the analysis cassette so that, for example, when blood is supplied, the sample liquid is sent to the portion in the form of serum.

  The analysis unit has a positioning mechanism that holds the analysis cassette and supplies a desired reagent to the reaction unit of the analysis cassette. Further, the positioning mechanism is configured to move to a place where analysis is actually performed.

  According to the present invention, it is possible to provide a chemical analyzer in which a user can arbitrarily set a reagent according to an analysis item, and which is compact, portable, and easy to maintain, and does not require piping for washing liquid, waste liquid, and the like.

  An embodiment of the present invention will be described with reference to FIGS. FIG. 1 is an overall configuration diagram of an embodiment of a chemical analysis device of the present invention, FIG. 2 is an explanatory diagram of a reagent weighing discharge pump used in the present invention, FIG. 3 is a configuration diagram of a disposable analysis cassette, and FIGS. FIG. 7 is a configuration diagram showing another embodiment of the analysis cassette of the present invention, and FIGS. 7 and 8 show an overall configuration diagram of another embodiment of the present invention.

  The configuration of the chemical analyzer of the present invention will be described with reference to FIGS. FIG. 1 is a diagram showing the overall configuration of the components of the present chemical analyzer viewed obliquely from above.

  The analyzer according to the present embodiment mainly includes two components. An analysis cassette 1 which is a holding carrier having a region for temporarily holding a disposable reagent or a sample liquid, and an analyzer main body 2 into which the analysis cassette 1 is loaded. The analyzer main body 2 includes a linear drive unit 21 that is a position adjustment unit that includes a holding carrier locking unit that temporarily locks the analysis cassette 1 and that is a position adjustment unit that performs position adjustment. A row of reagent bottles 23 provided with a reagent weighing and discharging pump 22 which is a reagent discharging means for discharging a predetermined amount of reagent into the cassette 1, a photodetector 24 provided on the leftmost side of the linear drive section 21, an analysis item, etc. , A signal processing unit 25 for recording information such as the setting order of the reagent bottles 23, and displaying and recording the analysis results, and receiving an instruction of an operation procedure from the signal processing unit 25, It comprises a weighing discharge pump 22 and a controller 26 for sending a control signal to the photodetector 24. The reagent 3 is supplied from the reagent weighing discharge pump 22 to a reaction cell provided in the analysis cassette 1 described later.

  Next, the configuration of the reagent weighing discharge pump 22 and the reagent bottle 23 to which the present pump is added according to the present embodiment will be described with reference to FIG. A hole 231 is provided at the bottom of the reagent bottle 23. A diaphragm-type reagent weighing discharge pump 22 shown in FIG. 2 (2) is provided so as to communicate with the hole 231. Check valves 221 and 222 that flow only in one direction are provided at the inlet and the outlet of the reagent weighing discharge pump 22. Further, a diaphragm 223 is provided in the pump chamber, and a diaphragm 224 is attached to an outer surface. Wiring for applying a voltage is provided at both ends of the diaphragm 224. The outlet of the diaphragm type reagent weighing discharge pump 22 is opened downward, and a nozzle 225 for smoothing the discharge flow is provided. The wiring of the vibration plate 224 is connected to an electric contact 227 provided in a holder 226 that holds the reagent weighing discharge pump 22 by a driving wiring.

  Next, the configuration of the analysis cassette 1 of the present invention will be described with reference to FIG. The analysis cassette 1 is roughly composed of two substrates. One is composed of a detection substrate 182 provided with the reaction cell 16 and the like, and an upper substrate 181 provided on the detection substrate 182. The size of this analysis cassette is a business card size of about 55 mm in width and about 90 mm in length.

  The upper substrate 181 is provided with an introduction hole 11 'for engaging with a syringe 41 for introducing a sample solution, and air communicating with air vent micro holes 131 and 142 provided at the ends of the micro channels 13 and 145 described later. It comprises holes 131 ′ and 142 ′ and a notch 19 for detection for supplying a reagent to the reaction section or performing analysis. The upper substrate 181 is fixed to the detection substrate 182 with an adhesive or the like.

The detection substrate 182 of the analysis cassette 1 of the present embodiment is provided with one sample introduction unit 11 for introducing a sample solution. The introduction section 11 communicates with the introduction hole 11 ′ of the upper substrate 181. A flow resistance is given to the blood cell component below the introduction part 11,
A filter 12 that allows the serum component to pass preferentially is provided. The flow path provided after the filter 12 is branched and divided into ten narrow micro flow paths 13. A first micro hole 131 is provided at the end of each micro channel 13, and is opened to the atmosphere via micro holes 131 ′ provided in the upper substrate 8.

  A slide-type quantitative valve 14 that can cut out a certain amount of serum by sliding is incorporated in the micro flow path 13. The microchannel 141 in the valve is connected to the microchannel 13 until the serum is injected and the microchannel 141 of the slide type quantitative valve 14 is filled with serum. When the serum is filled, the whole slides and fits into the other microchannel 145. The upstream end of the minute flow path 145 is open to the atmosphere from the second minute holes 142 through the minute holes 142 ′ of the upper substrate 8. At the other downstream end, a test paper 15 is provided in a region or site for holding the liquid. Here, the test paper 15 may be formed of paper or a fibrous substance, and may be any substance that can carry serum or reagents and has a white, hygroscopic substance. The test paper 15 is extended as it is in the reaction cell 16.

  The upper part of the reaction cell 16 is an open window. In this embodiment, a portion of the upper substrate 8 facing the reaction cell 16 is cut out to form a window 19. When the analysis cassette 1 is not used, the cutout on the upper substrate 8 side is covered with a seal member so that dust and the like do not enter the reaction cell, and the seal is peeled off when used. It goes without saying that a portion of the upper substrate 8 facing the reaction cell 16 may be slid and opened. The reagent 3 is discharged onto the test paper 15 through the window 19. Of the ten reaction cells 16, the lowermost cell in the figure is provided with an electrode 161 for measuring the electrolyte in the serum, and a signal line between the connector 162 and the connector 162 is provided by a signal line inside the cassette. They are connected.

  With this configuration, the present device operates as follows.

  First, the blood 4 (whole blood) containing blood cells is sent out from the introduction section 11 of the analysis cassette 1 using the syringe 41. At that time, the serum component preferentially enters the internal flow path over the blood cell component by the filter 12. The serum component is pressurized in the branched ten micro channels 13 by the pressure of the syringe 41 and the capillary force, and is filled up to the first micro holes 131 through the micro channels 141 of the slide type fixed quantity valve 14. In this state, one end of the slide type fixed quantity valve 14 is pushed in a direction of an arrow 143 in FIG. As a result, the part of the minute flow path 141 is fitted into the other minute flow path 145. The volume of the micro flow path 141 in the slide type quantitative valve 14 is constant, and high-precision quantitative sampling is performed. In this embodiment, the flow path having a size of 0.2 mm square and a length of 7.5 mm is formed in the minute flow path in the measurement valve, whereby 0.3 μl of a trace amount of serum is quantitatively collected with high precision. Of course, the sampling amount can be arbitrarily set by adjusting the size of the microchannel 141.

  A certain amount of serum fitted into the micro flow path 141 in the slide type fixed quantity valve 14 is sucked by the end of the test paper 15 at the other outlet, and spreads evenly to the test paper 15 in the reaction cell 16. At this point, the determined serum 4 has penetrated into each test paper 15 in the analysis cassette 1. The analysis cassette 1 is set on the linear drive unit 21 of the apparatus main body 2.

  When a start input is given from the signal processing unit 25, the reagent bottles 23 are sequentially selected from the reagent bottle group in the order of the measurement items set in advance, and the reaction cells 16 of the analysis cassette 1 are linearly driven below the reagent bottles 23. It moves by 21. Thereafter, the reagent weighing and discharging pump 22 provided at the lower part of the reagent bottle 23 is operated by the control signal of the controller 26, and a predetermined amount of the reagent 3 is discharged aiming at the test piece 15 of the reaction cell 16. By the same operation, different reagents 3 are sequentially discharged to the adjacent reaction cells 16.

  A predetermined amount of diluent is discharged to the ninth and tenth reaction cells 16. In the test paper 15, since the reagent 3 spreads evenly on the test paper 15 due to the capillary phenomenon, the reagent 3 and the serum 4 are mixed and reacted almost uniformly without unevenness. If left in this state, the reaction proceeds on each test paper 15 and color or light emission starts. The linear drive unit 21 operates at regular intervals to move the test paper 15 of the analysis cassette 1 to the lower part of the photodetector 24. The photodetector 24 measures the spectrum intensity and the light emission intensity on the test paper 15 as needed. For the ninth cell, the absorption spectrum of the diluted serum itself is measured. In the tenth cell, the ion concentration in the serum is detected by the electrolyte sensor 161.

  As described above, by appropriately moving the linear drive unit 21 in parallel and monitoring the reaction process in each reaction cell 16, measurement can be performed with the same accuracy as that of a large-sized automatic analyzer. The analysis cassette 1 for which measurement has been completed is disposable.

  As described above, in a conventional chemical analyzer using a disposable unit, the measurement items are already determined by the manufacturer. Therefore, it is uneconomical to repeatedly analyze over a plurality of units or to measure unnecessary items until a result of a truly necessary combination of analysis items is obtained.

  On the other hand, in the chemical analyzer of this embodiment, since the disposable analysis cassette 1 is used, the user can arbitrarily select test items independently without deteriorating the maintainability, handling, portability, etc. can do. That is, first, the reagent bottle 23 of an item frequently used according to the use environment of the user is selected and attached to the analyzer main body 2. Next, a more optimal combination can be selected and measured from the reagent bottles 23 attached before the analysis. In addition, since all components (analysis cassettes) that use blood are disposable, there is no need to perform processing such as cleaning liquids and waste liquids, and maintenance is easy. Further, as an effect of the present embodiment, since the structure of the analysis cassette 1 has the same shape, size, and specifications, the cassette cost can be significantly reduced by mass production.

  Next, a second embodiment of the present invention will be described with reference to FIG.

  The analyzer main body 2 is similar to the embodiment of FIG. The first embodiment is different from the first embodiment in the method of quantitatively collecting the serum 4 in the analysis cassette 1 and the method of supplying and detecting the reagent. As shown in FIG. 4A, the analysis cassette 1 of this embodiment is provided with a rotary valve 17 subsequent to the blood introduction section 11, and does not require the slide type quantitative valve 14. That is, the distribution flow path 171 is formed radially in the rotary valve 17, and the branching is performed here and the quantitative measurement is also performed here. At the time of introducing blood, the rotary valve 17 is not connected to the micro flow path 13, and is rotated and connected to the micro flow path 13 after blood is filled in a branch path provided in the rotary valve 17.

  As shown in FIG. 4 (2), a portion 132 that expands with a step is provided in the middle of the microchannel 13. The reaction cell 16 is provided in connection with the enlarged portion 132. A thin film 162 is formed on the upper part of the reaction cell 16 so that it can be easily pierced by the injection needle 226. A reflector 163 for introducing and emitting light to the reaction cell 16 is provided before and after the reaction cell 16. The rotary valve 17 is provided with a passage 172 for sending compressed air to a symmetrical position in addition to the radial distribution passage 171. Further, a syringe for injecting air for sending compressed air is also provided. In this embodiment, the rotation of the rotary valve 17 is manually performed. However, the apparatus body may have a mechanism for automatically rotating the rotary valve. Also, the supply of the compressed air may be automatically performed from the apparatus main body. In this embodiment, the reagent weighing / discharging pump 22 is provided with an injection needle 226 for piercing instead of the nozzle 225. The linear drive unit 21 of the apparatus main body also has a mechanism for moving the analysis cassette 1 up and down.

  The above configuration operates as follows. First, the analysis cassette 1 is set on the linear drive unit 21 of the apparatus main body 2. The linear drive unit 21 moves so that the reaction cell 16 of the analysis cassette 1 is located below a predetermined reagent bottle 23. Next, the ascending injection needle 226 is pierced into the membrane 162 on the upper part of the reaction cell 16. In this state, the reagent weighing and discharging pump 22 is operated to inject a predetermined amount of the reagent 3 into the reaction cell 16 through the injection needle 226. This operation is similarly performed for the other nine reaction cells 16.

  Thereafter, as shown in FIG. 4 (3), the analysis cassette 1 is taken out of the apparatus main body 2, and a syringe 41 containing blood 4 as a sample liquid is charged into the sample introduction section 11 and dropped. Only the serum is distributed to the microchannel 13 via the filter 12. The serum enters the step portion 132 of the microchannel 13 by capillary action, but stops at that location due to the step.

  Thereafter, as shown in FIG. 4C, the rotary valve 17 is rotated to switch the upstream side of the minute flow path 13 so as to be connected to the passage 172 for compressed air. Thus, a certain amount of the serum 4 in the microchannel 13 is collected. Furthermore, a syringe for sending compressed air is filled in the introduction portion 11 and the air is sent into the passage, whereby the serum is released into each reaction cell 16. The mixing of the serum and the reagent 3 is promoted by the flow of releasing the serum and the ensuing air.

Next, the analysis cassette 1 is loaded into the linear drive unit 21 of the apparatus main body 2 again.
If the mixing is insufficient in the previous operation, in some cases, as shown in FIG. 4 (4), the mixing may be performed acoustically by contacting a stirrer 164 that emits ultrasonic waves into the reaction cell. . When the reaction progresses and the color develops, the absorption spectrum or light emission in the sequential reaction cell 16 is detected as in the first embodiment.

  In this case, as shown in FIG. 4 (5), the photodetector 24 is arranged below the analysis cassette 1, and light is applied to the reflecting portions 163 provided before and after the reaction cell 16, whereby the reaction cell Light can be transmitted below the liquid level in the liquid crystal 16 and high-precision measurement not affected by bubbles or the like on the liquid level can be performed.

  Next, a third embodiment will be described with reference to FIG. The device configuration of this embodiment is substantially the same as that of the first embodiment. The difference is that the linear drive unit 21 is provided with an elevating mechanism so that the nozzle 225 of the reagent weighing and discharging pump 22 is directly in close contact with the position of the second microhole 142 of the analysis cassette 1. For this reason, it is not necessary to provide a notch window at a position corresponding to the reaction part of the inspection substrate on the upper substrate of the analysis cassette 1.

  As shown in FIG. 5 (2), as in the first embodiment, a predetermined amount of serum is collected from the analysis cassette 1 by the slide type quantitative valve 14, and then the analysis cassette 1 is moved to the linear drive unit 21 of the apparatus main body 2. Load it. In this embodiment, the nozzle 225 of the reagent weighing / discharging pump 22 comes into close contact with the second minute hole 142 of the analysis cassette 1 directly. When the reagent 3 is discharged in this state, the reagent 3 is released into the reaction cell 16 while pushing out the serum, as shown in FIG. The reagent 3 and the serum are mixed in the flow at the time of this release. Since the air in the reaction cell 16 is discharged to the outside through the air holes 165, it is not compressed. After that, as in the first and second embodiments, the spectral intensity and the luminous intensity are measured using the reflectors 163 around the reaction cell 16.

  A fourth embodiment will be described with reference to FIG. In the fourth embodiment, one planar reaction cell 18 is provided in the analysis cassette 1. A high-precision television camera 241 is provided instead of the light detector 24 of the analyzer main body 2 in the first embodiment. Further, the linear drive section 21 is a mechanism for two-dimensionally moving the analysis cassette 1 in a plane. A portion of the upper substrate 8 facing the reaction cell 18 is notched.

  First, the blood 4 injected from the introduction part 11 passes through the filter 12 and only the serum spreads in the planar cell 18. In this state, the analysis cassette is loaded into the linear drive unit 21 of the apparatus main body 2. The linear drive section 21 moves the analysis cassette 1 two-dimensionally, and positions the nozzle 225 of the predetermined reagent weighing discharge pump 22 at a predetermined position of the planar reaction cell 18. In this state, a predetermined amount of the reagent 3 is discharged. By performing the same operation, as shown in FIG. 6A, different reagents are discharged in a matrix while maintaining a constant interval. At each ejection position 185, diffusion mixing gradually proceeds at the boundary between the injected reagent 3 and the surrounding serum. In the case of a minute region, this progress is controlled only by the molecular diffusion depending on the concentration gradient, and mixing with good reproducibility is achieved.

  The mixed reaction generated at the interface between the reagent 3 and the serum is captured by the television camera 241 and the reaction process is measured. If the time and the degree of diffusion are tested in advance, the mixture ratio can be specified, and the concentration of the dissolved substance can be estimated from the color development / emission state there. The analysis cassette 1 of the present embodiment has a simple structure as compared with the other embodiments, so that the manufacturing cost can be reduced. Also, by narrowing the interval of ejection in a matrix and minimizing the ejection amount of the reagent, an extremely large number of spots can be formed, and a feature that many items can be measured simultaneously at the same time is obtained.

  In the first to fourth embodiments, the analysis cassette 1 has been described as being composed of two large substrates. However, the upper substrate is not necessarily required, and may be composed of only the inspection substrate. In this case, it is necessary to make the shape of the introduction portion 11 for blood injection of the test substrate matched with the shape of the discharge port of the syringe, and to cover the reaction cell 16 with a seal when not in use. Each of these substrates can be formed of a resin material such as plastic.

  FIG. 7 shows a configuration diagram of a chemical analysis system according to the fifth embodiment of the present invention. The system of the present invention comprises the analyzer main body of the first embodiment as a reagent loading dedicated device 5 (a reagent bottle, a reagent weighing and discharging pump group, a linear drive unit, a signal processing unit, and a controller) for loading a reagent into an analysis cassette. ) And an analysis terminal device 6 (consisting of a linear drive unit and a photodetector) for performing analysis of the analysis cassette exclusively. The analysis terminal device 6 is installed in plural sets or more.

The system is used as follows. First, the reagent 3 is pre-loaded into the analysis cassette 1 using the reagent loading dedicated device 5 as desired by each user. In this way, a large number of analysis cassettes 1 customized to desired analysis items can be manufactured at a location close to the inspection work of the user. Each user has only the analysis terminal device 5, and the blood 4 is introduced into the analysis cassette 1 which is filled and prepared in advance, and only analysis is performed.
In such an analysis system, the cost of the analysis terminal device 6 itself is reduced, and the analysis terminal device 6 can be deployed to more users. As a matter of course, by connecting these terminals 6 and the reagent loading device 5 via a network, it is possible to monitor the excess / deficiency information of the analysis cassette 1 and the production status, etc., and furthermore, to trust the analysis values by mutual communication of the measurement data. This can be useful for improving the performance.

FIG. 8 shows a sixth embodiment of the present invention. The basic configuration is the same as that of the first embodiment. In the first to fifth embodiments, the analysis cassette 1 has a rectangular shape, but the present embodiment differs in that the analysis cassette 1 has a disk shape. In this embodiment, of course, the blood introduction portion 11 is provided at the center, and the minute flow channels 13 are provided radially. With this configuration, the reagent container 23 and the reagent weighing / discharging pump 22 may be linearly driven, and the analysis cassette 1 may be driven to rotate, thereby increasing the speed of light detection.

It is a block diagram of the chemical analyzer of the present invention. It is a block diagram of the reagent supply part of this invention. FIG. 2 is a configuration diagram of an analysis cassette of the present invention. It is a block diagram of another analysis cassette of this invention. It is a block diagram of another analysis cassette of this invention. It is a block diagram of another analysis cassette of this invention. It is a block diagram of the chemical analysis system of another Example of this invention. It is a block diagram of the chemical analyzer of another Example of this invention.

Explanation of reference numerals

DESCRIPTION OF SYMBOLS 1 ... Analysis cassette, 2 ... Analyzer main body, 3 ... Reagent, 4 ... Blood, 5 ... Reagent loading-only device, 6 ... Analysis terminal device, 11 ... Introduction part, 13 ... Microchannel, 14 ... Sliding type quantitative valve, Reference numeral 15: test paper, 16: reaction cell, 17: rotary valve, 18: reaction cell, 21: linear drive unit, 22: reagent weighing discharge pump, 23: reagent bottle, 24: photodetector, 25: signal processor, 26: controller, 161: electrolyte sensor, 225: nozzle.

Claims (8)

In a chemical analyzer that mixes a reagent and a sample liquid, reacts the component with the reagent in the sample liquid, and measures the concentration of the component,
An introduction part for injecting the specimen liquid, a branch flow path for distributing the specimen liquid injected from the introduction part, and a holding carrier having a plurality of reaction parts for retaining and reacting the specimen liquid with a reagent,
A driving unit mounted with the holding carrier and movable,
Reagent discharging means for sequentially discharging different types of reagents for each reaction portion of the holding carrier,
A chemical analyzer comprising: a detection unit that detects a component after mixing the reagent and a sample liquid. The chemical analyzer according to claim 1, wherein a fibrous substance having a hygroscopic property is provided in a reaction part of the holding carrier. The chemical analyzer according to claim 1,
The chemical analyzer according to claim 1, wherein the holding carrier is provided with a quantitative unit for defining an amount to be used for the test of the sample liquid. The chemical analyzer according to claim 3,
The quantitative section is provided in a branch flow path between the introduction section and the reaction section, and a flow path from the introduction section and a flow path to the reaction section are separated, and the quantitative section is moved. A chemical analysis apparatus characterized in that the respective flow paths are connected to each other. The chemical analyzer according to claim 1,
A chemical analyzer having a filter between the inlet and the distribution channel or in the middle of the distribution channel for separating and removing solid components in the sample liquid. The chemical analyzer according to claim 1, wherein one of the reaction sections of the holding carrier is provided with an ion sensor for directly measuring an ion concentration in a sample liquid. In a chemical analyzer that mixes a reagent and a sample liquid, reacts the component with the reagent in the sample liquid, and measures the concentration of the component,
An introduction part for injecting the specimen liquid, a filter for filtering the specimen liquid injected from the introduction part, the liquid passing through the filter is distributed on a plane, and a holding carrier having a reaction part for dropping a reagent,
A driving unit mounted with the holding carrier and movable;
Reagent discharging means for sequentially discharging different types of reagents onto different surfaces of the reaction section of the holding carrier,
A detector for detecting a component of the mixture near the drop of the reagent. In a chemical analysis system that mixes a reagent and a sample solution, reacts the target component with the reagent in the sample solution, and measures the concentration of the component,
A disposable holding carrier having an area or a plurality of portions for temporarily holding a liquid,
Holding carrier locking means for temporarily locking the holding carrier,
Sample distribution means for sequentially distributing the same sample liquid to a plurality of different positions on the holding carrier,
Adjusting the relative position of the reagent discharging means and the sample liquid holding position, an analysis terminal comprising a position adjusting means for matching,
A reagent filling device for sequentially discharging and filling different types of reagents in advance to the respective sample liquid holding portions of the holding carrier.

Images