JP2004219278A - Sampling/preserving implement for urine specimen - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a sampling/preserving implement for urine specimens with a favorable preserving state of sampled urine specimens by preventing a gap between the outer circumferential part of a filter and a space part, completely filtering bacteria, and preventing bacterial contamination. <P>SOLUTION: The sampling/preserving implement for urine specimens is composed of a sampling holder 3 for the urine specimens with a cover body 2 connected to a lower part of a container holder 1, and a container 5 of the urine specimen closed in a decompressed state by a plug body 4. A cylindrical part 7 is provided below a cylinder body 6 of the container holder, a cylindrical part 9 is provided above a base part 8 of the cover body, a cylindrical pressing body 10 is provided in an inner circumference of the cylindrical part 7 or the cylindrical part 9, the filter is held by pressing the outer circumferential part of the filter 11 by the cylindrical pressing body in a space S formed in interiors of the cylindrical part 7 and the cylindrical part 9 by fitting them together, an injection needle 12 communicated with the space is provided in the cylinder body, a specimen suction tube 13 communicated with the space is provided below the base part, and the container can be inserted into the cylinder body of the container holder from a plug body side. <P>COPYRIGHT: (C)2004,JPO&NCIPI

Description

[0001]
TECHNICAL FIELD OF THE INVENTION
BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a urine sample collection / storage device that enables a collected urine sample to be stored for a long time without denaturation in a urine test in the field of clinical diagnosis.
[0002]
[Prior art]
A urine test can be measured without imposing a burden on a subject at the time of sample collection, and is therefore widely used in a screening test at an outpatient initial examination and a group test, a daily test for follow-up, and the like.
[0003]
A urine sample collected from a subject is denatured in a relatively short time by endogenous or exogenous bacteria, oxygen, light, and the like, and therefore, it is considered preferable to measure the urine sample within 3 to 4 hours after collection. If a urine sample is to be left for 3-4 hours or more after collection, it must be stored in a closed or refrigerated or frozen state. After storage, the urine sample is returned to room temperature at the time of the test and the measurement is performed.
[0004]
If the urine sample is left as it is in the open air due to endogenous or exogenous bacteria, the bacteria may propagate and the components in the urine sample may change. Furthermore, since there is a component unstable to oxygen and light in the urine sample, accurate measurement may not be possible if the urine sample is left in the open air. In particular, when measuring a large amount of urine sample as in a mass examination, the measurer and the measuring device should be resident and allowed to perform the measurement within a short time, or the urine sample should be kept in a refrigerated or frozen state, and sealed. You may need to make inefficient choices, such as sometimes thawing. In addition, urine samples collected in areas or facilities that do not have measurement means must not only be kept refrigerated or frozen, but also preserved when transported to facilities where measurement is possible. Economic transportation is needed.
[0005]
Therefore, even if the collected urine sample is stored at room temperature for several days, accurate measurement can be performed without changing the components in the urine sample, and the collected urine sample is also refrigerated or frozen at the time of mass screening. The present inventors have invented a device for collecting and storing a urine sample that can be easily transported and inspected without performing the above-mentioned treatment.
[0006]
As shown in FIGS. 11 and 12, the urine sample collection and storage device invented by the present inventors includes a filter holder 22 holding a urine sample filter 21 and a urine sample sealed under reduced pressure by a plug 23. And a sample container 24. The filter holder 22 has a space S for holding the filtration filter 21, an outer cylinder 22 a is provided on the upper side of the sample delivery side, and an injection needle 25 communicating with the space S is provided in the outer cylinder 22 a. Further, a sample aspirating tube 26 communicating with the space S is provided at the lower part of the sample taking side. In order to communicate the sample aspirating tube 26 with the space S, the sample aspirating tube 26 is communicated with a communication hole 27a of a lid 27 that seals the space S from below. The container 24 can be inserted into the outer cylinder 22a of the filter holder 22 from the plug 23 side (see Patent Document 1).
[0007]
[Patent Document 1]
JP-A-2002-311021 (page 2 right column to page 3 left column, FIG.
(Fig. 2)
[0008]
[Problems to be solved by the invention]
However, in the above-mentioned conventional urine sample collection / storage device, the space S of the filter holder 22 holding the filtration filter 21 is simply sealed by the lid 7. Since only bacteria are retained, bacteria may pass through a gap formed between the outer peripheral portion of the filtration filter 21 and the space S and the bacteria may be incompletely filtered. There is a problem that the storage state may be deteriorated.
[0009]
Therefore, the present invention has an object to solve the above conventional problems, so that no gap is formed between the outer peripheral portion and the space portion of the filtration filter, so that bacteria pass only through the filtration filter, The purpose of the present invention is to provide a device for collecting and preserving urine specimens in which the filtration of bacteria is completed and the collected urine specimens are kept well without bacterial contamination.
[0010]
[Means for Solving the Problems]
Therefore, the urine sample collection / storage device of the present invention comprises a urine sample collection holder 3 in which a cover 2 is connected below a container holder 1 and a urine sample container 5 hermetically sealed by a stopper 4. A cylindrical part 7 is provided below the cylindrical body 6 of the container holder 1, a cylindrical part 9 is provided above the base 8 of the cover body 2, and a cylindrical part 7 or a cylindrical part is provided on the inner periphery of the cylindrical part 9. A cylindrical pressing body 10 is provided, and the outer peripheral portion of the filter 11 is pressed by the cylindrical pressing body 10 into a space S formed therein by fitting the cylindrical part 7 and the cylindrical part 9. It is assumed that the filter filter 11 is held, the injection needle 12 communicating with the space S is provided in the cylindrical body 6, and the sample suction pipe 13 communicating with the space S is provided below the base 8. The container 5 can be inserted from the side of the plug 4 into one cylinder 6 It is assumed that was.
[0011]
The urine sample collection / storage instrument of the present invention is configured such that the cylindrical portion 7 and the cylindrical portion 9 are forcibly fitted between the cylindrical portion 9 and the cylindrical pressing body 10. It is assumed that they are fitted.
[0012]
Further, in the urine sample collection / storage device of the present invention, the cylindrical portion 9 and the cylindrical portion 9 are forcibly fitted between the cylindrical portion 7 and the cylindrical pressing body 10 so that the cylindrical portion 7 and the cylindrical portion 9 are connected to each other. They can be fitted.
[0013]
In addition, the urine sample collecting / storing device of the present invention may be provided with a stepped circumferential groove 10 a on the outer periphery of the cylindrical pressing body 10.
[0014]
BEST MODE FOR CARRYING OUT THE INVENTION
Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings.
[0015]
First, FIGS. 1 to 3 show an embodiment of the present invention, in which a urine sample collection holder 3 in which a cover body 2 is connected below a container holder 1 and a urine sample container which is hermetically sealed by a stopper 4. 5 is comprised.
[0016]
The container holder 1 is provided with a tubular portion 7 below the tubular body 6, and the cover body 2 is provided with a tubular portion 9 above the base 8, and a tubular pressing member is provided inside the tubular portion 9. The body 10 is provided. Then, the outer periphery of the filtration filter 11 is pressed by the cylindrical pressing body 10 into a space S formed therein by fitting the cylindrical portion 7 and the cylindrical portion 9 to each other. 11 is held. The fitting of the tubular portion 7 and the tubular portion 9 is performed by forcibly fitting the tubular portion 7 between the tubular portion 9 and the tubular pressing body 10.
[0017]
An injection needle 12 communicating with the space S is provided in the cylindrical body 6 of the container holder 1, and a sample suction tube 13 communicating with the space S is provided below the base 8 of the cover 2. And If necessary, a plurality of arc-shaped flow grooves 14a are formed on the lower surface 6a of the cylindrical body 6 in the circumferential direction, and a plurality of radial flow grooves 14b are formed in the center direction. On the upper surface 8a of the base 8, a plurality of arc-shaped flow grooves 15a are formed in the circumferential direction, and a plurality of radial flow grooves 15b are formed in the center direction. As a result, the urine sample sucked from the sample suction tube 13 flows along the flow grooves 15a and 15b and diffuses on the upper surface 8a, is absorbed uniformly by the filtration filter 11, and is efficiently filtered. Are made to flow along the flow grooves 14a and 14b, and are collected at the center of the lower surface 6a so that they can be efficiently sent to the injection needle 12.
[0018]
A flange 16 for finger contact is provided on the outer peripheral upper portion of the cylindrical body 6. Further, a flange 17 for connecting the cover body 2 is provided at a lower part of the outer periphery of the cylindrical body 6. Locking grooves 19 for locking locking claws 18 of the cover 2 described later are provided at a plurality of positions on the outer periphery of the flange 17. Further, a stepped circumferential groove 10a is provided on the outer periphery of the cylindrical pressing body 10.
[0019]
Next, FIGS. 4 to 6 show another embodiment of the present invention. A urine sample collection holder 3 in which a cover body 2 is connected below a container holder 1 and a urine sample sealed under reduced pressure by a stopper 4. Container 5.
[0020]
The container holder 1 has a tubular portion 7 provided below the tubular body 6 and a tubular pressing body 10 provided inside the tubular portion 7. The cover body 2 has a tubular shape above the base 8. A part 9 is provided. Then, the outer periphery of the filtration filter 11 is pressed by the cylindrical pressing body 10 into a space S formed therein by fitting the cylindrical portion 7 and the cylindrical portion 9 to each other. 11 is held. The fitting of the tubular portion 7 and the tubular portion 9 is performed by forcibly fitting the tubular portion 9 between the tubular portion 7 and the tubular pressing body 10.
[0021]
An injection needle 12 communicating with the space S is provided in the cylindrical body 6 of the container holder 1, and a sample suction tube 13 communicating with the space S is provided below the base 8 of the cover 2. And If necessary, a plurality of arc-shaped flow grooves 14a are formed on the lower surface 6a of the cylindrical body 6 in the circumferential direction, and a plurality of radial flow grooves 14b are formed in the center direction. On the upper surface 8a of the base 8, a plurality of arc-shaped flow grooves 15a are formed in the circumferential direction, and a plurality of radial flow grooves 15b are formed in the center direction. As a result, the urine sample sucked from the sample suction tube 13 flows along the flow grooves 15a and 15b and diffuses on the upper surface 8a, is absorbed uniformly by the filtration filter 11, and is efficiently filtered. Are made to flow along the flow grooves 14a and 14b, and are collected at the center of the lower surface 6a so that they can be efficiently sent to the injection needle 12.
[0022]
A flange 16 for finger contact is provided on the outer peripheral upper portion of the cylindrical body 6. Further, a flange 17 for connecting the cover 2 is provided at a lower portion of the outer periphery of the cylindrical body 6. Locking grooves 19 for locking locking claws 18 of the cover 2 described later are provided at a plurality of positions on the outer periphery of the flange 17. Further, a stepped circumferential groove 10a is provided on the outer periphery of the cylindrical pressing body 10.
[0023]
The filtration filter 11 in both embodiments is made of a material such as cellulose acetate or polysulfone or polyethersulfone, which has a low adsorptivity for a test component in urine such as a protein, and has a circular shape, and a diameter of the cylindrical portion 7 or The inside diameter of the cylindrical portion 9 is substantially the same, and the pore size is 0.05 μm to 0.2 μm so that the specimen can be filtered smoothly without passing bacteria.
[0024]
The container 5 is made of a material and a structure that shuts off the air. The container 5 is once filled with an inert gas such as nitrogen gas, is evacuated, and is sealed with a stopper 4 made of synthetic rubber or the like. . It is necessary to reduce the pressure of the container 5 to such an extent that a sufficient amount of urine sample can be collected in the container 5, and extreme pressure reduction affects the efficiency of maintaining the pressure and the durability of the container. The pressure in the container 5 is preferably set to 0.1 atm to 0.5 atm. Further, the size and shape of the container 5 are preferably a test tube shape or a bottle shape which can be attached to a general urine test apparatus. However, the container 5 can be inserted into the cylinder 6 of the container holder 1 from the plug 4 side. There is no particular limitation as long as it is one. Further, it is preferable that the container 5 has a light-shielding function, because the influence of light on the collected urine sample can be reduced.
[0025]
The sample aspirating tube 13 can be made of glass or synthetic resin, and may or may not have flexibility. There is no particular limitation as long as the sample is not aspirated.
[0026]
The urine sample collecting and preserving instrument of the present invention is such that the cover 2 is connected below the container holder 1 so that the container 5 can be inserted from the plug 4 side into the cylinder 6 of the container holder 1. And
[0027]
To connect the container holder 1 and the cover body 2, the cylindrical part 7 and the cylindrical part 9 are fitted as described above, and the cover body 2 is fitted into the locking groove 19 provided in the flange 17 of the container holder 1. What is necessary is just to lock the locking claw 18 provided in the base 8.
[0028]
By doing so, the outer peripheral portion of the filtration filter 11 is pressed by the cylindrical pressing body 10, and is further sandwiched by the step peripheral grooves 10 a on the outer periphery of the cylindrical pressing body 10, so that the filtration filter 11 is sealed. In the space S.
[0029]
Although not shown, the urine sample collection / storage device of the present invention is provided with a locking claw 18 on the flange 17 of the container holder 1 and a locking groove 19 on the base 8 of the cover 2. It can also be. In addition, the urine sample collecting / storing device of the present invention may not include the locking claw 18 and the locking groove 19. In this case, in order to connect the container holder 1 and the cover body 2, the tubular portion 7 and the tubular portion 9 may be fitted, and then these two may be ultrasonically welded.
[0030]
As shown in FIGS. 1, 3 and FIGS. 4 and 6, the urine sample collecting / storing device of the present invention thus constructed is configured such that the container 5 is injected into the cylinder 6 of the container holder 1 from the stopper 4 side. It is in a state of being inserted up to just before the needle 12. Then, as shown in FIGS. 7 and 9, the sample suction tube 13 is immersed in a urine sample collected in a urine collection cup U or the like, and the container 5 is further inserted into the cylinder 6 of the container holder 1. The injection needle 12 is pierced. Then, the urine sample collected in the urine collection cup U or the like flows into the container 5 from the sample suction tube 13 through the filtration filter 11 due to the reduced pressure of the container 5 which is sealed under reduced pressure. Further, as shown in FIGS. 8 and 10, by removing the container 5 from the container holder 1 and pulling out the injection needle 12 pierced into the stopper 4, the urine sample is collected in the container 5. The urine sample collected in the above can be stored as it is.
[0031]
【The invention's effect】
The urine sample collection / preservation instrument of the present invention is configured as described above, so that no gap is formed between the outer peripheral portion and the space portion of the filtration filter, so that bacteria pass only through the filtration filter. Then, since the filtration of the bacteria is completed, the preserved state of the collected urine sample is improved without causing bacterial contamination.
[Brief description of the drawings]
FIG. 1 is a perspective view showing one embodiment of a urine sample collection / preservation instrument of the present invention.
FIG. 2 is an exploded perspective view of a collection holder of the urine sample collection and storage device of the present invention shown in FIG.
FIG. 3 is a cross-sectional view of the urine sample collection and storage device of the present invention shown in FIG.
FIG. 4 is a perspective view showing another embodiment of the urine sample collection / preservation instrument of the present invention.
FIG. 5 is an exploded perspective view of the urine sample collection / storage device of the present invention shown in FIG.
FIG. 6 is a cross-sectional view of the urine sample collection and storage device of the present invention shown in FIG.
FIG. 7 is a perspective view showing a use state of the urine sample collecting / preserving device of the present invention shown in FIG. 1;
FIG. 8 is a perspective view showing a use state of the urine sample collecting / preserving instrument of the present invention shown in FIG. 1;
FIG. 9 is a perspective view showing a use state of the urine sample collection and storage device of the present invention shown in FIG.
FIG. 10 is a perspective view showing the state of use of the urine sample collection / storage device of the present invention shown in FIG.
FIG. 11 is a perspective view of a conventional urine sample collection and storage device.
FIG. 12 is a cross-sectional view of a conventional urine sample collection and storage device.
[Explanation of symbols]
DESCRIPTION OF SYMBOLS 1 Container holder 2 Cover body 3 Sampling holder 4 Plug body 5 Container 6 Cylindrical body 7 Cylindrical part 8 Base 9 Cylindrical part 10 Cylindrical pressing body 10a Step peripheral groove 11 Filtration filter 12 Injection needle 13 Sample suction pipe S Space

Claims (4)

A container holder (3) having a cover body (2) connected below the container holder (1) and a urine sample container (5) sealed under reduced pressure by a stopper (4); A tubular portion (7) is provided below the tubular body (6) of (1), a tubular portion (9) is provided above a base (8) of the cover body (2), and further a tubular portion (7). Alternatively, a cylindrical pressing body (10) is provided on the inner periphery of the cylindrical portion (9), and the cylindrical portion (7) and the cylindrical portion (9) are fitted to each other to form a space ( S), the outer periphery of the filtration filter (11) is pressed by the cylindrical pressing body (10) to hold the filtration filter (11), and the injection needle (12) communicating with the space (S) is inserted into the cylinder. It is provided in the body (6), and further, a sample suction pipe (13) communicating with this space (S) is provided below the base (8). The container cylindrical body of the holder (1) (6) in the container (5) a plug (4) can be inserted from the side and then collected and stored instrument urine specimen, characterized in that the. The cylindrical part (7) and the cylindrical part (9) are fitted by forcibly fitting the cylindrical part (7) between the cylindrical part (9) and the cylindrical pressing body (10). The urine sample collection / preservation instrument according to claim 1, characterized in that: The cylindrical portion (7) and the cylindrical portion (9) are fitted by forcibly fitting the cylindrical portion (9) between the cylindrical portion (7) and the cylindrical pressing body (10). The urine sample collection / preservation instrument according to claim 1, characterized in that: The urine sample collection / storage device according to any one of claims 1 to 3, wherein a stepped circumferential groove (10a) is provided on an outer periphery of the cylindrical pressing body (10).

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