JP2003335621A - Antifungal low irritative cosmetic - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a cosmetic not exhibiting primary irritation and sensitizing potential to the skin, and also not imparting a stinging pain or unpleasant feeling such as irritating sensation or pricking sensation in application to the skin, exhibiting an effective antifungal property free from reduction of the antifungal activity by formulating a cosmetic base and other formulating components. <P>SOLUTION: The antifungal low irritative cosmetic is formulated with an extract of vegetables belonging to Salicaceae and one or more than two kinds of compounds selected from the group consisting of ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, 1,2-pentandiol, 3-methyl-1,3-butanediol, hexylene glycol, digycerin, an alkyl ether of a polyalcohol, parahydroxybenzoate esters, phenoxyethanol, photosensitive dye No.101, photosensitive dye No.201, photosensitive dye No.401, hinokitiol, its derivatives and their salt, an N-long chain acyl basic amino acid derivative and its acid addition salt or zinc oxide. <P>COPYRIGHT: (C)2004,JPO

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a cosmetic which has excellent antibacterial properties, is not contaminated by microorganisms such as bacteria and mold, and is stable and has low irritation to the skin. More specifically, ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, 1,2-pentanediol, 3-methyl-1,3-butanediol (isopropylene glycol), Hexylene glycol, diglycerin, polyhydric alcohol alkyl ethers, paraoxybenzoates, phenoxyethanol, Photosensitizer No. 101 (Platonin), Photosensitizer 20
No. 1 (Pionine), Photosensitizer No. 401 (Luminex), Hinokitiol and its derivatives and salts thereof, N-long chain acyl basic amino acid derivatives and their acid addition salts, and one selected from the group consisting of zinc oxide, or The present invention relates to a hypoallergenic cosmetic product having a high antibacterial property, which comprises a combination of two or more kinds of antibacterial agents or antibacterial agents and an extract of Salicaceae plants.

[0002]

2. Description of the Related Art Conventionally, cosmetics containing water such as lotions, milky lotions and creams have been treated with various antibacterial agents in order to prevent deterioration due to contamination of microorganisms such as bacteria and mold during production and use. Molds have been used. Examples of such antibacterial and antifungal agents include isopropylmethylphenol, paraoxybenzoic acid ester, phenols such as phenoxyethanol, hinokitiol, benzoic acid and its salts, salicylic acid and its salts, dehydroacetic acid and its salts, sorbic acid and its salts, and the like. Acids, quaternary ammoniums such as benzalkonium chloride, benzethonium chloride and alkyltrimethylammonium chloride, amphoteric surfactants such as alkylaminoethylglycine hydrochloride and sodium stearylhydroxyethylbetaine chloride, and photosensitizers are used.

However, many of the above-mentioned antibacterial and antifungal agents have been reported to have primary irritation, sensitization or photosensitization to the skin, and the amount thereof is regulated by the standard of cosmetic raw materials from the viewpoint of safety. However, it is often not possible to mix an amount that actually shows effective antibacterial activity. Furthermore, even if the skin does not show irritation or sensitization reaction such as redness, rash, or edema, it may cause discomfort such as stinging pain, tingling or tingling when using cosmetics. Are known. Further, it may not exhibit sufficient antibacterial activity due to the interaction with the base material of the cosmetic or other components.

For example, isopropylmethylphenol,
When oil-soluble antibacterial and antifungal agents such as paraoxybenzoic acid ester and sorbic acid are mixed with cosmetics containing a polymer thickener and powder, the antibacterial activity is reduced due to adsorption and the like. Further, in the cosmetics containing the surfactant, the antibacterial activity is also decreased due to the incorporation into the surfactant micelle.
However, if a large amount is blended in the expectation of sufficient antibacterial activity, problems such as crystal precipitation at low temperature and stability of the product will occur.

Further, water-soluble antibacterial agents such as benzoate, salicylate and dehydroacetate are not effective unless the pH of the cosmetic is weakly acidic, and even when they are used under acidic conditions, they are acidic. Becomes stronger, the solubility in water decreases,
This may cause precipitation of crystals.

Further, regarding quaternary ammonium compounds and amphoteric surfactants, skin irritation and eye mucous membrane irritation are recognized, foaming is likely to occur, and antibacterial activity decreases on the acidic side.
There are practical problems such as interaction with anionic substances.

[0007]

Therefore, according to the present invention, a cosmetic base or other compounding ingredients exhibit an effective antibacterial action without lowering the antibacterial activity, and, as far as possible, an antibacterial and antifungal agent. The amount of the compound is reduced to obtain a cosmetic that not only shows no primary irritation or sensitization to the skin, but also does not cause discomfort such as stinging pain, tingling sensation, or tingling sensation when using cosmetics. It was intended.

In order to solve the above problems, the stability is high,
As a result of examining the antibacterial and antifungal system having low irritation to the skin,
Ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, 1,2-pentanediol, 3-methyl-1,3-butanediol (isopropylene glycol), hexylene glycol, Diglycerin, polyhydric alcohol alkyl ether, paraoxybenzoates, phenoxyethanol, photosensitizer 10
No. 1 (Platonin), Photosensitizer 201 (Pionine), Photosensitizer 401 (Luminex), Hinokitiol and its derivatives and their salts, N-long-chain acyl basic amino acid derivatives and their acid addition salts, and zinc oxide By combining and combining one or more selected from the group with an extract of Salicaceae plant, not only synergistically improved antibacterial activity but also irritation and discomfort to the skin The inventors have found that the reduction is significantly reduced and have completed the present invention.

Regarding the effectiveness of Salicaceae plant extracts, the whitening action of dihydromyricenan contained in leaves (JP-A-63-316711) and anti-mutagenic action (JP-A-1-17532), and bark extraction It is already known that the histamine release-inhibiting effect of the product (JP-A-10-287582), the fibroblast activation effect of salicin contained in the bark and leaves in large amounts (JP-A-11-80002), and the like.

However, according to the present invention, the antibacterial activity, which is obtained by using a Salicaceae plant extract in combination with a specific antibacterial component, is synergistically improved in antibacterial activity and reduces irritation and discomfort to the skin. No effect has ever been suggested.

[0011]

BEST MODE FOR CARRYING OUT THE INVENTION Willow family ( Salica) used in the present invention
ceae ) plants include Chosenia arbutifolia (Pallas) A. Skvortz; Ch.
osenia bracteosa Nakai), cottonwood willow ( porcupine ,
Poplar) the genus of cottonwood (Populus) (Populus siebo
ldi Miq.), Dero ( Populus maxmowiczii He
nry), Populus alba
L.), American Poppy ( Populus deltoides Mars
h .; Populus monilifera Ait .; Populus angulata Ai
v.), populus euphratica (Populus euphratica Oliv.), Europe Black Mountain break-in (Populus nigra L.), Populus nigra (Populus nigra var. italica Koehne) , Europe mountain leveling (Populus tremula), Salix of Kasupiyanagi (Salix acutifolia L.) , European willow
(Salix alba L .; Salix aurea Salisb .), Salix (Itoyanagi) (Salix babylonica L.), wildcat willow (Bakkoyanagi) (Salix bakko Kimura), Akameyanagi (Salix chaenomeloides Kimura), Naga bus sallow
Salix gilgiana Seemen., Salix gracilistyla Miq., Salix integra Thunb., Salix j
aponica Thunb.), Salix kinuyanagi Kimur
a), Koryanagi ( Salix koriyanagi Kimura; Salix pur
purea var. japonica Nakai), Frisode willow ( Salix l
eucopithecia Kimura), Salix matsu
dana Koidz.), Japanese willow tree
( Salix nakamurana Koidz.), Salix nigr
a ), Salix purpurea L., Salix purpurea L., Salix sachalinensis Fr. Sch
m.), willow tree ( Salix reinii Fr. e)
t Sav.), Salix sieboldiana Bl., Salix viebalis L .; Salix longifolia
Lam.), Fox willow ( Salix vulpin )
a), Oobayanagi genus Oobayanagi (Toisusu urbaniana
Salix urbaniana ), etc. are exemplified. Among these, especially from the viewpoint of its antibacterial action, the European porcupine ( Pop
ulus tremula ), willow ( Salix alba L .; Sa
lix aurea Salisb.), Salix (Itoyanagi) (Sal
ix babylonica L.), black willow ( Salix nigra ), purple willow ( Salix purpurea L.)
It is preferred to use more than one plant, and most preferred is Salix nigra bark extract. The site for obtaining an extract from a Salicaceae plant is not particularly limited, but a bark, a leaf and a female flower are preferably used in view of its antibacterial action.

Extraction solvents for obtaining extracts of these Salicaceae plants include water, ethanol, methanol, isopropanol, isobutanol, n-hexanol, methylamyl alcohol, 2-ethylbutanol,
Alcohols such as n-octyl alcohol, glycerin, ethylene glycol, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether,
Propylene glycol, propylene glycol monomethyl ether, propylene glycol monoethyl ether, triethylene glycol, 1,3-butylene glycol, hexylene glycol and other polyhydric alcohols or their derivatives, acetone, methyl ethyl ketone, methyl isobutyl ketone, methyl-n-propyl Ketones such as ketones, esters such as ethyl acetate and isopropyl acetate,
One or more mixed solvents selected from polar solvents such as ethers such as ethyl ether, isopropyl ether, n-butyl ether, etc. can be preferably used, and phosphate buffered saline can also be used. However, it is not particularly limited. For the purpose of the present invention, a polar solvent is preferable from the viewpoint of antibacterial activity, and further, one or more mixed solvents selected from methanol, ethanol, 1,3-butylene glycol, and water, particularly water, may be used. It is preferably used as a solvent.

Examples of the extraction method include a method of immersing at room temperature, cooling or heating, an extraction method using a distillation method such as steam distillation, and a raw Salixaceae .
Examples of the method include a pressing method of pressing a plant to obtain an extract, and these methods are used alone or in combination of two or more kinds.

[0014] Without being limited especially Salicaceae (Salicaceae) the ratio of plant and solvent used in the extraction, solvent for Salicaceae (Salicaceae) Plant 1 0.5 to 1000
The weight is preferably 0.5 to 100 times, particularly in terms of extraction operation and efficiency. Further, the extraction temperature is conveniently in the range of room temperature to the boiling point of the solvent or less under normal pressure, and the extraction time is preferably in the range of 2 hours to 2 weeks, although it varies depending on the extraction temperature and the like.

The Salixaceae plant extract thus obtained can be used as it is, but it can be used for deodorization, decolorization, concentration, etc. within the range of not losing the antibacterial activity of the present invention. It may be used as a fractionated product by adding a purification operation or further using column chromatography or the like. These extracts, purified products, and fractions can be made into a dry solid by removing the solvent from them, and can be provided in the form of being solubilized in a solvent such as alcohol, or in the form of an emulsion. it can.

In the present invention, the above-mentioned Salixaceae ( Sali
caceae ) plant extract and ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, 1,2-pentanediol, 3-methyl-1,3-butanediol (isopropylene Glycol), hexylene glycol, diglycerin, alkyl ethers of polyhydric alcohols, paraoxybenzoic acid esters, phenoxyethanol, photosensitizer No. 101 (platonin), photosensitizer 20
No. 1 (Pionine), Photosensitizer No. 401 (Luminex), Hinokitiol and its derivatives and salts thereof, N-long chain acyl basic amino acid derivatives and their acid addition salts, and one selected from the group consisting of zinc oxide, or Two or more antibacterial agents and antibacterial assistants are used in combination.

Ethylene glycol, diethylene glycol, triethylene glycol used in the present invention,
Propylene glycol, dipropylene glycol, 1,3-
Butylene glycol, 1,2-pentanediol, 3-methyl
-1,3-butanediol (isopropylene glycol),
Hexylene glycol and diglycerin are used as moisturizers and antibacterial aids in ordinary cosmetics.

As the polyhydric alcohol alkyl ether used in the present invention, glycols or glycerin alkyl ether can be preferably used, and particularly,
Ethylene glycol monomethyl ether, ethylene glycol monoethyl ether (ethyl ethellosolve), ethylene glycol monobutyl ether (butyl cellosolve), ethylene glycol dimethyl ether, diethylene glycol monomethyl ether (methyl carbitol), diethylene glycol monoethyl ether (ethyl carbitol), diethylene glycol monobutyl ether , Diethylene glycol dimethyl ether, diethylene glycol diethyl ether, propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol monoisopropyl ether, dipropylene glycol monomethyl ether, dipropylene glycol monoethyl ether, glyceryl monopalmityl Ether (Kimi alcohol),
Glyceryl monostearyl ether (batyl alcohol), glyceryl monooleyl ether (ceracyl alcohol), etc. are exemplified as preferable ones, and one or more of them are selected and used.

These ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, 1,2-pentanediol, 3-methyl-1,3-butanediol (isopropylene glycol), Hexylene glycol, diglycerin, polyhydric alcohols, or alkyl ethers of polyhydric alcohols show antibacterial activity at 5.0% by weight or more alone, but when added to complex systems such as cosmetics, they are sufficient. In many cases, no antibacterial action is observed.
However, in the present invention, synergistic enhancement of antibacterial activity is recognized, and a sufficient antibacterial action is exhibited with a compounding amount of about 5.0 to 10.0% by weight.

As the paraoxybenzoic acid esters,
Examples include methyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, butyl paraoxybenzoate, isopropyl paraoxybenzoate, and isobutyl paraoxybenzoate. In the present invention,
When used in combination with an extract of Salixaceae plants,
Since a synergistic improvement in antibacterial activity is observed, the blending amount of these is about 0.01 to 0.2% by weight.

With respect to phenoxyethanol, in the present invention, a sufficient antibacterial activity can be obtained with a blending amount of about 0.05 to 0.3% by weight. In addition, each of photosensitive element 101 (platonin), photosensitive element 201 (pionine), and photosensitive element 401 (luminex) is 0.00.
A blending amount of about 01 to 0.002% by weight is sufficient. With respect to hinokitiol and its derivatives and salts thereof, a proportion of 0.0001 to 0.1% by weight is suitable.

The N-long chain acyl basic amino acid derivative is represented by the following general formula (1), general formula (2) and general formula (3).
(However, in the general formulas (1) to (3), RCO is a saturated or unsaturated fatty acid residue having 6 to 20 carbon atoms, and X is -N.
_{H 2, -OCH 3, -OC 2} H 5, -OC 3 H 7, -OC 4 H 9 or -
OCH ₂ C ₆ H ₅ is shown, and in the general formula (2), n is 3 or 4
Are shown), and one or more selected from these and these acid addition salts are used.

[0023]

[Chemical 1]

[0024]

[Chemical 2]

[0025]

[Chemical 3]

Examples of such N-long chain acyl basic amino acid derivatives include N-caproyl-L-arginine methyl ester hydrochloride, N-lauroyl-L-arginine ethyl ester-DL-pyrrolidone carboxylate and N-palmitoyl-L. -Arginine ethyl ester hydrochloride, N-cocoyl-L-arginine ethyl ester-DL-pyrrolidone carboxylate, N-caproyl-L-lysine methyl ester hydrochloride, N-lauroyl-L-lysine ethyl ester-DL-pyrrolidone carboxylate Acid salt, N-myristoyl-L-lysine propyl ester hydrochloride, N-cocoyl-L-lysine methyl ester-DL-pyrrolidone carboxylate, N-stearoyl-L-histidine methyl ester hydrochloride, N-oleoyl-L -Histidine ethyl ester-DL-pyrrolidone carboxylate and the like are exemplified.
An appropriate amount of blending is about 0.001 to 0.5% by weight.

The antibacterial hypoallergenic cosmetics according to the present invention can be provided in various dosage forms such as lotions, emulsions, gels, creams, ointments, powders and granules. In addition, skin lotion, emulsion, cream, beauty essence, skin cosmetics such as packs, makeup base lotion, foundation cosmetics such as makeup base cream, foundations, eye lotions for each formulation such as emulsion, oil, and solid. Makeup cosmetics such as color, cheek color, cleansing cream,
It can also be provided as a skin cleansing agent such as cleansing lotion, cleansing foam, face wash soap, body shampoo, etc., and hair cosmetics such as hair shampoo, hair rinse, hair treatment, hairnic, hair styling agent, etc.

The antibacterial hypoallergenic cosmetics according to the present invention include oily ingredients, surfactants, humectants, pigments in addition to Salicaceae plant extracts and specific antibacterial agents and antibacterial aids. It is possible to include general raw materials for pharmaceuticals and cosmetics such as ultraviolet absorbers, antioxidants, and fragrances, and physiologically active ingredients such as cell activating agents, anti-inflammatory agents, and whitening agents.

[0029]

EXAMPLES First, an example of the production of Salicaceae plant extracts used in the examples of the present invention is shown. Further, the features of the present invention will be described in detail with reference to examples.

Production Example 1 Black willow bark extract To 200 g of fresh bark of black willow ( Salix nigra ) collected in the spring was shredded, 1000 g of purified water was added, and the mixture was extracted at 25 ° C. for 36 hours while stirring. . The obtained extract was filtered and then concentrated under reduced pressure to obtain 150 g of willow bark extract.

[Production Example 2] European porcupine leaf extract Fresh leaves of European porcupine ( Populus tremula ) 2
1000g of purified water was added to 00g, and
Extract for 36 hours at 25 ° C. with stirring. The obtained extract was filtered and then concentrated under reduced pressure to obtain 120 g of a porcupine leaf extract.

Production Example 3 European Willow Bark Extract Dried European willow ( Salix alba L .; Salix aur
ea Salis b.) 50g is crushed and 50% by volume ethanol 1
Add 000 g and extract at room temperature for 24 hours. The obtained extract was filtered, concentrated under reduced pressure, and then freeze-dried to obtain 5 g of a willow bark extract.

[Production Example 4] Weeping willow leaf extract Fresh weeping willow ( Salix babylonica )
L.) 100 g of purified water is added to 10 g of the sprout, and the mixture is extracted with stirring by a mixer for 10 minutes. The obtained extract was filtered, concentrated under reduced pressure, and lyophilized to obtain 1.2 g of weeping willow leaf extract.

Further, regarding the details of the present invention, prescription examples of antibacterial hypoallergenic cosmetics containing the Salicaceae plant extract shown in the above-mentioned production examples are shown.

[Example 1] Lotion (1) Ethanol 5.0 (wt%) (2) 1,2-Pentanediol 6.0 (3) Glycerin 2.0 (4) Polyoxyethylene (50EO) Curing Castor oil 0.6 (5) Willow bark extract 0.5 (6) Phenoxyethanol 0.05 (7) Perfume 0.05 (8) Purified water 85.8 Production method: Add each component of (1) to (7) Sequentially add to (8) and mix uniformly.

Example 2 Emulsion (1) Squalane 4.0 (% by weight) (2) Glyceryl tri-2-ethylhexanoate 2.0 (3) Cetyl 2-ethylhexanoate 3.0 (4) Cetanol 0.6 (5) Stearyl alcohol 0.4 (6) Sorbitan monostearate 1.2 (7) 1,3-Butylene glycol 6.0 (8) Glycerin 4.0 (9) Polyoxyethylene (20EO) Sorbitan 0.8 Monostearate (10) Purified water 73.899 (11) Photosensitizer No. 101 0.001 (12) European poppy leaf extract 4.0 (13) Perfume 0.1 Manufacturing method: First, ( The oil phases 1) to (6) are mixed, heated and melted and kept at 75 ° C. On the other hand, the aqueous phases (7) to (10) are mixed, heated and melted to 75 ° C., and the oil phase is added thereto with stirring to emulsify. After cooling, (11) to (13) are sequentially added and mixed at 40 ° C.

Example 3 Cream (1) Stearyl alcohol 6.0 (% by weight) (2) Stearic acid 2.0 (3) Hydrogenated lanolin 4.0 (4) Squalane 9.0 (5) Octyldodeca Nool 10.0 (6) Polyoxyethylene (25EO) cetyl alcohol ether 3.0 (7) Glyceryl monostearate 2.0 (8) 1,3-butylene glycol 6.0 (9) Purified water 56.81 (10) Ethanol 1.0 (11) Willow bark extract 0.05 (12) Propyl paraoxybenzoate 0.04 (13) Perfume 0.1 Production method: Mix the oil phase components of (1) to (7) , Heat to 75 ° C. On the other hand, the water phase components of (8) and (9) are mixed and heated to 7
The temperature was adjusted to 5 ° C, and the oil phase was added to this to emulsify, and after cooling, 4
The components (11) to (13) are dissolved in (10) and added at 0 ° C.

[Example 4] Oil-based cleansing cream (1) ceresin 8.0 (% by weight) (2) microcrystalline wax 5.0 (3) white petrolatum 35.0 (4) squalane 49.89 (5) stearin Magnesium acid 2.0 (6) Butyl paraoxybenzoate 0.01 (7) Weeping willow leaf extract 0.1 Production method: The components (1) to (6) are mixed and heated to gel,
After cooling, the component (7) is added at 40 ° C.

[Example 5] Milk liquid foundation (1) Stearic acid 2.4 (% by weight) (2) Propylene glycol monostearate 2.0 (3) Cetostearyl alcohol 0.2 (4) Liquid lanolin 2. 0 (5) Liquid paraffin 3.0 (6) Isopropyl myristate 8.5 (7) Sodium carboxymethyl cellulose 0.2 (8) Bentonite 0.5 (9) Propylene glycol 4.0 (10) Triethanolamine 1. 1 (11) Purified water 56.48 (12) Willow bark extract 1.5 (13) Hinokitiol 0.02 (14) Perfume 0.1 (15) Titanium oxide 8.0 (16) Talc 4.0 (17) ) Red iron oxide 3.0 (18) Yellow iron oxide 2.5 (19) Black iron oxide 0.5 Manufacturing method: After mixing the pigments of (15) to (19), the mixture is ground through a grinder. (11) was heated to 70 ° C., (8) was added to swell well, (7) was dispersed in (9) in advance, and (10) was added and dissolved to form an aqueous phase. To do. (1)-(6)
The oily phases are mixed, heated and melted to 80 ° C. The pigment is added to the aqueous phase with stirring and passed through a colloid mill for 75
C., the oil phase is added with stirring to emulsify, and after cooling, the components (12) to (14) are added at 40.degree.

[Example 6] Powder foundation (1) Talc 36.0 (wt%) (2) Mica 20.0 (3) Nylon powder 15.0 (4) Titanium oxide 10.0 (5) Zinc oxide 2 5 (6) Red iron oxide 3.0 (7) Yellow iron oxide 2.5 (8) Black iron oxide 0.5 (9) Squalane 5.0 (10) Octyldodecyl myristate 2.5 (11) Macadamian nuts Oil 2.5 (12) Perfume 0.15 (13) European porcupine leaf extract 0.35 Production method: (1) to (8) are mixed and pulverized through a pulverizer.
This is transferred to a high speed blender, and (9) to (13) are added and mixed to make uniform. After further processing with a crusher and adjusting the particle size through a sieve, it is filled in a gold plate and compression molded.

Example 7 Aqueous Suspension Mascara (1) 50 wt% Vinyl Acetate Emulsion 30.0 (wt%) (2) Sodium Carboxymethyl Cellulose 1.0 (3) 1,3-Butylene Glycol 3.0 (4) Willow bark extract 0.1 (5) Methyl paraoxybenzoate 0.1 (6) Titanium oxide 8.0 (7) Carbon black 1.6 (8) Red iron oxide 0.4 (9) Purified water 55 .8 Manufacturing method; (2) to (5) were added to (9) to dissolve, and then
Add (6) to (8) and disperse through a colloid mill. Add (1) to this and disperse evenly.

Example 8 Shampoo (1) Sodium alkyl ether sulfate 18.0 (% by weight) (2) Coconut oil fatty acid diethanolamide 2.0 (3) Weeping willow leaf extract 0.25 (4) N-cocoyl -L-arginine ethyl ester -DL-pyrrolidone carboxylic acid salt 0.05 (5) Yellow No. 4 1% by weight aqueous solution 0.1 (6) Perfume 0.1 (7) Purified water 79.5 Manufacturing method: (1) to (6) is sequentially added to (7), and they are mixed and dissolved uniformly.

[Example 9] Hair rinse (1) Cetanol 2.0 (% by weight) (2) Stearyl trimethyl ammonium chloride 2.0 (3) Silicone oil 3.0 (4) Polyoxyethylene oleyl ether (10EO) 1 0.0 (5) glycerin 3.0 (6) N-myristoyl-L-lysine ethyl ester hydrochloride 0.07 (7) willow bark extract 2.0 (8) fragrance 0.1 (9) purified water 86. 83 Process: Add (5) and (6) to (9) and heat to 70 ° C. On the other hand, (1) to (4) are mixed, dissolved and heated to 70 ° C. This oil phase is gradually added to the previously prepared aqueous phase while stirring, and preliminarily emulsified, and a homomixer is added to homogenize and then cooled.
(7) and (8) are added at 40 ° C.

[Example 10] Hair cream (1) Polyoxyethylene (10EO) behenyl ether 5.0 (% by weight) (2) Hexyldecanol 5.0 (3) Liquid paraffin 35.0 (4) Purified lanolin 2 0.0 (5) Cetanol 2.0 (6) Glycerin 5.0 (7) European porcupine leaf extract 0.2 (8) Purified water 45.699 (9) Perfume 0.1 (10) Photosensitive No. 401 0 .001 Production method: The oil phase components (1) to (5) are mixed and heated to 75 ° C. On the other hand, the water phase components (6) to (8) are mixed and heated to 7
The temperature was adjusted to 5 ° C, and the oil phase was added to this to emulsify, and after cooling, 4
Add (9) and (10) at 0 ° C.

[Example 11] Hair treatment (1) Polyoxyethylene (30EO) behenyl ether 4.0 (wt%) (2) Self-emulsifying glyceryl monostearate 6.0 (3) Isopropyl myristate 5. 0 (4) Hexyldecanol 5.0 (5) Squalane 3.0 (6) Purified lanolin 3.0 (7) Stearic acid 5.0 (8) Lauryl dimethylamino acetic acid betaine 5.0 (9) Glycerin 5.0 ( 10) Purified water 58.62 (11) Perfume 0.2 (12) Willow bark extract 0.1 (13) Phenoxyethanol 0.08 Method: Mix and heat the oil phase components (1) to (7) To 80 ° C. On the other hand, mix (8) to (10) water phase components and heat to
The temperature was adjusted to 5 ° C, and the oil phase was added to this to emulsify, and after cooling, 4
Add (11)-(13) at 0 ° C.

Example 12 Face Wash (1) Liquid Paraffin 25.0 (wt%) (2) Cetanol 2.0 (3) Lanolin 2.0 (4) Glyceryl Monostearate 5.0 (5) Poly Oxyethylene stearyl ether 5.0 (6) Polyoxyethylene (20EO) sorbitan monostearate 1.0 (7) Glycerin 2.0 (8) Purified water 57.798 (9) Perfume 0.1 (10) Weeping willow leaf Extract 0.1 (11) Photosensitive No. 201 0.002 Production method: The oil phase of (1) to (6) and the aqueous phases of (7) and (8) were mixed and heated to 65 ° C., respectively, and then dissolved in oil. The aqueous phase is added to the phase and emulsified. After cooling, (9) to (11) are added and mixed at 40 ° C.

Example 13 Body Shampoo (1) Sodium Lauryl Ether Sulfate 20.0 (wt%) (2) Sodium Myristyl Ether Sulfate 10.0 (3) Diethanolamide Capric Acid 3.0 (4) Polyoxypropylene (10PO) Polyoxyethylene (20EO) Cetyl ether 3.5 (5) Sodium chloride 2.5 (6) Willow bark extract 0.5 (7) Perfume 0.3 (8) Photosensitizer No. 201 0.001 ( 9) Purified water 60.199 Manufacturing method: Each component of (1) to (8) is sequentially added to (9) and mixed uniformly.

Next, the above Examples 1 to 13 were evaluated for antibacterial activity, skin irritation, discomfort during use, and storage stability. At the same time, Examples 1 to 1
3, the Salixaceae ( Sa
licaceae ) A plant extract was replaced with purified water to prepare a comparative example, and the antibacterial activity was evaluated in the same manner. However, in Example 4,
In Example 5, an antiseptic / antifungal agent was added for the purpose of preventing secondary contamination during use, and therefore the antibacterial activity was not evaluated.

(1) Evaluation of antibacterial activity As bacteria, Escherichia coli , Staphylococc
us aureus ), Pseudomonas aeruginosa , and Propionibacterium acnes as fungi as Candida albicans and Aspergillus
niger ), and dandruff fungus ( Malassezia furfur ), and inoculates 10 ⁶ bacteria and 10 ⁵ fungi per 1 g of the sample,
After culturing at 37 ° C. and 25 ° C. respectively, the viable cell count after 2 weeks was measured. It should be noted that the antibacterial activity is 2 weeks later, and when bacteria are killed, the viable cell count is 1/10 for fungi.
When it was 00 or less, it was determined to pass. The results of the antibacterial activity test are shown in Tables 1 and 2 as "O" when they passed and "X" when they failed.

[0050]

[Table 1]

[0051]

[Table 2]

As is clear from Table 1, in Examples of the present invention, sufficient antibacterial activity against both bacteria and fungi was observed. On the other hand, as shown in Table 2, the comparative examples not containing the Salicaceae plant extract did not meet the acceptance criteria for some test bacteria.

(2) Evaluation of skin irritation In each Example, a male panelist was used for a 48-hour occlusion patch test and evaluated according to the criteria shown in Table 3, and the skin irritation index of 20 persons was averaged. The value was calculated. In addition, Examples 8 to 9,
For 12 and 13, a 1.0 wt% aqueous solution was used for the test.

[0054]

[Table 3]

(3) Evaluation of discomfort during use A group of 20 female panelists was used, and each group was allowed to use each of the examples, and the stinging pain and tingling felt during 30 seconds to 1 minute after application They were asked to evaluate discomfort such as feeling and tingling. The evaluation result is "very strong; 5 points",
Evaluated as "slightly strong; 4 points", "feeling; 3 points", "a little feeling; 2 points", "delicately feeling; 1 point", "not feeling; 0 points", and averaged to 20 people Showed.
Also in this case, regarding Examples 8 to 9, 12, and 13,
A 1.0 wt% aqueous solution was used for the test. The above results are shown in Table 4.
Are summarized in.

[0056]

[Table 4]

In Table 4, no skin irritation was observed in any of the examples of the present invention.
The discomfort during use is only subtly felt.

Regarding Examples 1 to 13 of the present invention,
It was left to stand in a constant temperature bath of 40 ° C. for 6 months, and the storage stability was observed. As a result, in all of the examples, no change was observed in the state such as precipitation of the content components.

[0059]

As described above in detail, according to the present invention, the stability is good, the antibacterial action is synergistically enhanced, and not only the skin irritation but also the stinging pain and tingling sensation during use are obtained. It was possible to obtain an antibacterial cosmetic composition with almost no discomfort such as a tingling sensation.

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Claims (5)

[Claims] 1. A Salicaceae plant extract,
Ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, 1,2-pentanediol, 3-methyl-1,3-butanediol (isopropylene glycol), hexylene glycol, Diglycerin, polyhydric alcohol alkyl ether, paraoxybenzoates, phenoxyethanol, photosensitizer 10
No. 1 (Platonin), Photosensitizer 201 (Pionine), Photosensitizer 401 (Luminex), Hinokitiol and its derivatives and their salts, N-long-chain acyl basic amino acid derivatives and their acid addition salts, and zinc oxide Characterized by containing one or more selected from the group,
Antibacterial hypoallergenic cosmetics. 2. One of alkyl ethers of polyhydric alcohols.
One or more selected from ethylene glycol, diethylene glycol, triethylene glycol mono- and dialkyl ethers, propylene glycol, dipropylene glycol mono- and dialkyl ethers, glycerin mono-, di-, and trialkyl ethers. The antibacterial hypoallergenic cosmetic composition according to claim 1. 3. Extracts of Salicaceae (Salicaceae) plant, a water extract of Salicaceae (Salicaceae) plant, antibacterial hypoallergenic cosmetic composition according to claim 1 or claim 2. 4. Salicaceae (Salicaceae) extracts of plants is an extract from Salicaceae (Salicaceae) bark of plants, antimicrobial hypoallergenic cosmetic according to claims 1 to 3. 5. The antibacterial hypoallergenic cosmetic composition according to claim 1, wherein the extract of Salicaceae plant is a Salix nigra L. extract.