JP2003310578A - Biological signal measuring method and biological signal measuring apparatus - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a biological signal measuring method by which a biological signal is measured in the state of fixing a position of a part to be measured in an organism, an angle of the surface of the organism, an angle of a measuring probe to the surface of the organism and a contact pressure of the measuring probe to the surface of the organism and the highly reproducible measurement is performed without dispersion in the measured result for each measurement. <P>SOLUTION: In the biological signal measuring method, a measuring probe 8 is contacted to the surface of an organism 14, the surface of the organism 14 is irradiated with measuring light, reflected light from the organism is received and the biological signal is measured from a component of the received light. The method is composed of a step for adjusting the surface of the organism 14 to a prescribed angle while measuring the angle of the surface of the organism 14, a step for adjusting the measuring probe 8 to the prescribed angle while measuring the angle of the measuring probe 8, a step for contacting the measuring probe 8 with a prescribed position on the surface of the organism 14 with a prescribed pressure, and a step for irradiating the surface of the organism 14 with the measuring light from the measuring probe 8 and receiving the reflected light in the state of the preceeding step. <P>COPYRIGHT: (C)2004,JPO

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention irradiates a surface of a living body with measuring light, receives reflected light from the living body, and measures a living body signal from the received light component to non-invasively measure a blood glucose level and the like. The present invention relates to a biological signal measuring method and a biological signal measuring device that are capable of performing the above.

[0002]

2. Description of the Related Art Various information in a living body can be obtained by irradiating a living body surface with a measuring light, receiving reflected light of the measuring light received from the living body, and measuring a living body signal from the received light component. For example, since the absorption intensity of light is greatly affected by the presence of glucose, it is possible to detect the absorption intensity of light by measuring the spectrum of the received reflected light as a biological signal to detect the glucose concentration in the living body. It is possible to know the blood sugar level. According to this method, since it is not necessary to collect blood from the subject, the blood glucose level can be measured without imposing a heavy burden on the subject.

FIG. 19 shows an example of a system for measuring such a biological signal. In FIG. 19, 1 is a light source such as a halogen lamp, 2 is a diffusion plate, 3 is a pinhole, 4 is a lens, and the light from the light source 1 is a diffusion plate 2, a pinhole 3,
The light is incident on the light incident body 5 through the lens 4. One end of the irradiation side optical fiber 6 and one end of the reference irradiation side optical fiber 7 are connected to the light incident body 5. The other end of the irradiation side optical fiber 6 is connected to the measurement probe 8, and the other end of the reference irradiation side optical fiber 7 is connected to the reference probe 9. Further, one end of a detection side optical fiber 10 is connected to the measurement probe 8, and one end of a reference detection side optical fiber 11 is connected to the reference probe 9. The other end of the detection side optical fiber 10 is connected to the detection side light emitting body 12, and the other end of the reference detection side optical fiber 11 is connected to the reference detection side light emitting body 13.

Then, when the light source 1 is caused to emit light while the tip surface of the measuring probe 8 is in contact with the surface of the living body 14 such as an arm of a human body at a predetermined pressure, the light incident from the light source 1 onto the light incident body 5 is emitted. The light is transmitted through the irradiation side optical fiber 6 and is irradiated onto the surface of the living body 14 from the tip of the measurement probe 8. The measurement light applied to the living body 14 is reflected and diffused in the living body, and then the reflected light is received by the detection side optical fiber 10 from the tip of the measurement probe 8. The received light is transmitted through the detection-side optical fiber 10, and the detection-side light emitting body 12
Is emitted from. The light emitted from the detection-side light-side light-emitting body 12 is incident on the diffraction grating 16 through the lens 15 and is spectrally separated, and then detected by the light receiving element 17. The optical signal detected by the light receiving element 17 is AD-converted by the A / D converter 18 and then input to the arithmetic unit 19 such as a personal computer, and the spectrum which is the biological signal in the detected optical signal is analyzed. It is possible to calculate a blood glucose level and the like.

Here, there is a possibility that the spectrum of the reflected light to be measured will fluctuate due to fluctuations in the ambient environmental temperature and the positional relationship of the optical components, so it is necessary to correct this fluctuation. Therefore, the reference light reflected by the reference plate 20 such as a ceramic plate is measured, and the reference light is used as the reference light for correction. That is, the light incident on the light incident body 5 from the light source 1 is irradiated onto the surface of the reference plate 20 from the tip of the reference probe 9 through the reference irradiation side optical fiber 7. When the reflected light of the light applied to the reference plate is received by the reference detection-side optical fiber 11 from the tip of the reference probe 9, this reference light passes from the reference-detection-side optical fiber 11 to the reference-side detection-side light emitting body 13. Is emitted. Between the detection side light side light emitting body 12 and the lens 15,
And the detection side light emitting body 13 and the lens 1 for reference
5, shutters 21a and 21b are arranged respectively, and by selectively opening and closing the shutters 21a and 21b, the light from the detection-side light-side light-emitting body 12 and the light from the reference-side detection-side light-emitting body 13 for refans are removed. Either one of the lights is selectively passed. Then, by detecting the reference light from the reference-side detection-side light-emitting body 13 for refan-less use, this can be used as the reference light to correct fluctuations due to the ambient environmental temperature, the positional relationship of optical components, and the like.

[0006]

As described above, while the measuring probe 8 is in contact with the surface of the living body 14 such as the arm of the human body at a predetermined pressure, the surface of the living body 14 is irradiated with the measuring light and the living body 14 is irradiated with the measuring light. In measuring the biological signal by receiving the reflected light from, the operation is generally performed by holding the measuring probe 8 in hand and pressing the measuring probe 8 against a part of the surface of the living body 14. Is.

However, when the position of the measuring point of the living body 14, the angle of the surface of the living body 14, the angle of the measuring probe 8 with respect to the surface of the living body 14, the contact pressure of the measuring probe 8 with respect to the surface of the living body 14, and the like are different, There is a possibility that the absorption spectrum of light in the system may fluctuate, and therefore the detection results will vary from measurement to measurement and reproducibility cannot be obtained, making it difficult to perform accurate measurement. It was

The present invention has been made in view of the above points, in which the position of the measuring point of the living body, the angle of the living body surface, the angle of the measuring probe with respect to the living body surface, and the contact pressure of the measuring probe with respect to the living body surface are made constant. It is an object of the present invention to provide a biological signal measuring method and a biological signal measuring device which can perform measurement in a state and can perform highly reproducible measurement without variation in detection result for each measurement.

[0009]

According to a first aspect of the present invention, there is provided a biological signal measuring method, wherein a measuring probe is brought into contact with the surface of a living body, the measuring light is irradiated onto the surface of the living body, and reflected light from the living body is received. In the biological signal measuring method adapted to measure the biological signal from the light receiving component, the step of adjusting the biological surface to a predetermined angle while measuring the angle of the biological surface, the measurement probe at a predetermined angle while measuring the angle of the measuring probe. The step of adjusting, contacting the measurement probe at a predetermined position on the surface of the living body with a predetermined pressure in a state where the angle between the living body surface and the measuring probe is adjusted, in this state, irradiating the living body surface with the measuring light from the measuring probe and reflecting light. And a step of receiving light.

According to a second aspect of the present invention, there is provided a biological signal measuring method, wherein a measuring probe is brought into contact with the surface of a living body, the measuring light is irradiated onto the living body surface and reflected light from the living body is received. In the biological signal measuring method adapted to measure, the step of fixing the probe pedestal at a predetermined position on the biological surface, the step of fitting the measurement probe to the probe pedestal, the angle of at least one of the probe pedestal and the measurement probe Adjusting the angle of the living body surface so that the measuring probe is at a predetermined angle while measuring, contacting the measuring probe with a predetermined pressure on the living body surface while holding the measuring probe at this predetermined angle, in this state And a step of irradiating the measuring light from the measuring probe and receiving the reflected light.

According to a third aspect of the present invention, there is provided a biological signal measuring method in which a living body surface is brought into contact with a measuring probe, the living body surface is irradiated with measuring light, and reflected light from the living body is received. In the biological signal measuring method adapted to measure the step of fixing the probe pedestal to a predetermined position on the surface of the living body, while measuring the angle of the probe pedestal, the angle of the biological surface is adjusted so that the probe pedestal has a predetermined angle. Adjusting step, fitting the measurement probe to the probe pedestal while holding the probe pedestal at this predetermined angle, contacting the measurement probe with a predetermined pressure on the living body surface, in this state from the measurement probe to the living body surface And a step of irradiating the measurement light and receiving the reflected light.

The invention according to claim 4 is the measuring probe according to any one of claims 1 to 3, wherein the measurement probe guides and irradiates the measurement light from the light source, and the reflection reflected by the living body. The irradiation side light guide means and the detection side light guide means each have a center-to-center distance of a contact portion between the irradiation side light guide means and the detection side light guide means of 0.2 to. 2 mm
It is characterized in that they are arranged at intervals of.

Further, in the invention of claim 5, in any one of claims 1 to 4, the temperature of the contact portion of the measuring probe with the living body surface is heated so as to be the same as the temperature of the living body surface. It is a feature.

According to a sixth aspect of the present invention, there is provided a biological signal measuring device in which a measuring probe is brought into contact with the surface of a living body to irradiate the measuring light onto the surface of the living body and receive reflected light from the living body. In the biological signal measuring device adapted to measure, a means for positioning the measurement point on the biological surface at a predetermined position, a means for measuring the angle of the measurement point on the biological surface, a means for measuring the angle of the measurement probe, and a measurement A means for bringing the probe into contact with a measurement site on the surface of the living body at a predetermined pressure is provided.

According to a seventh aspect of the present invention, there is provided a biological signal measuring device in which a measuring probe is brought into contact with the surface of a living body to irradiate the measuring light onto the surface of the living body and receive reflected light from the living body. In a biological signal measuring device configured to measure, a measurement probe having a fitting portion, and a fitting portion to which the fitting portion of the measurement probe is fitted and used by being fixed to a predetermined position on the living body surface is provided. It is characterized by comprising a probe pedestal, means for measuring an angle of at least one of the probe pedestal and the measurement probe, and means for bringing the measurement probe into contact with the surface of the living body at a predetermined pressure.

According to an eighth aspect of the present invention, in the seventh aspect, the fitting portion of the measurement probe is formed in a rod shape, and the fitting portion of the probe pedestal has a shape in which the rod-shaped fitting portion is inserted and fitted. It is characterized by being formed in a tubular shape having a through hole.

According to a ninth aspect of the present invention, in the eighth aspect, the tubular contact surface of the cylindrical fitting portion of the probe holder with the living body surface is adhered to the living body surface over the entire circumference. It is characterized in that it is configured as follows.

The invention of claim 10 is the invention of claim 8 or 9.
In the above, the fitting portion of the measurement probe is fitted into the fitted portion of the probe holder so as not to rotate in the direction around the fitting.

Further, the invention of claim 11 relates to claims 6 to 1.
In any one of 0, the urging means for urging the measuring probe toward the surface of the living body is provided as means for bringing the measuring probe into contact with the surface of the living body at a predetermined pressure.

The twelfth aspect of the invention is the sixth to first aspects.
In any one of 1, the living body is a subject's arm, and a living body support portion that supports the arm portion so that the angle can be adjusted, and a grip bar that is arranged at one end edge of the living body support portion and held by the subject's hand, It is characterized by comprising.

[0021]

BEST MODE FOR CARRYING OUT THE INVENTION Embodiments of the present invention will be described below.

FIG. 2 shows an example of an embodiment of the measuring probe 8. The tip (lower end) of the probe shaft 24 is attached by inserting the probe shaft 24 in the center of the cylindrical probe drum 23. It is formed by protruding from. The probe shaft 24 is connected at its upper end to the irradiation side optical fiber 6 as the irradiation side light guiding means and the detection side optical fiber 10 as the detection side light guiding means. Then, as shown in FIG. 3A, the detection-side optical fiber 10 is passed through the central portion of the probe shaft 24.
As shown in (b), the tip is exposed at the center of the tip surface of the probe shaft 24. The irradiation-side optical fiber 6 is composed of a plurality of fibers, and as shown in FIG. 3A, the irradiation-side optical fiber 6 is passed through the probe shaft 24 so as to surround the detection-side optical fiber 10, and each tip thereof is brought into contact with the tip surface of the probe shaft 24. , Fig. 3
As shown in (b), it is exposed so as to be arranged at equal intervals on the circumference around the tip of the detection-side optical fiber 10. In addition, a plurality of detection side optical fibers 10 (for example, 2
3), the tip of each detection-side optical fiber 10 is exposed on the tip surface of the probe shaft 24, and the irradiation-side optical fiber 6 is arranged so as to surround the tip of each detection-side optical fiber 10. The tip may be exposed on the tip surface of the probe shaft 24.

As shown in FIG. 2B, the measuring probe 8 is provided with an urging means for contacting the probe shaft 24 with the surface of the living body 14 at a predetermined pressure. That is,
The probe shaft 24 is attached through the slide cylinder 36, and the slide flange 36 is attached to the lower end of the slide cylinder 36.
7 is overhanging. Then, the slide cylinder 36 is inserted into the probe cylinder 23 so that the lower end of the probe shaft 24 projects from the opening 38 at the lower end of the probe cylinder 23, and the fixing ring 39 inserted into the outer periphery of the slide cylinder 36 is attached to the probe cylinder 23. The slide cylinder 36 is mounted in the probe barrel 23 so as to be vertically slidable by being fixed to the inner circumference of the opening at the upper end of the. An elastic member 40 such as a coil spring is provided between the slide flange 37 and the fixed ring 39.
Is provided as an urging means, and the elastic member 40 urges the slide cylinder 36 downward so as to urge the probe shaft 24 to project downward. Here, a fixing screw 41 is threadedly attached to the slide flange 37 in the diametrical direction, and the fixing screw 41 is tightened in a state in which the dimension for projecting the tip of the probe shaft 24 from the lower end of the slide cylinder 36 is adjusted. The contact pressure of the probe shaft 24 can be adjusted by fixing the probe shaft 24.

The urging means for urging the measuring probe 8 can be formed by a solenoid using an electromagnet or the like in addition to the elastic member 40. When the biasing means is formed by the elastic member 40, there is an advantage that the configuration can be simplified, and when the biasing means is formed by a solenoid, the measurement probe 8 is attached to the living body 14. This has the advantage that the operation of bringing the surface into contact with a predetermined pressure can be electrically remote-controlled or automatically controlled to enable automatic measurement.

The measuring probe 8 may be provided with means for measuring the angle. In the embodiment of FIG. 2A, a flange 25 is provided on the outer periphery of the probe barrel 23 so as to project in a direction perpendicular to the axial direction of the probe shaft 24.
An angle measuring means is formed by attaching a spirit level 26 to the upper surface of 5. As the level 26, it is possible to use a level that is formed by enclosing water and bubbles so that a horizontal state can be measured by moving the bubbles to the center.

FIG. 4 shows an example of an embodiment of the probe pedestal 28, which has a through hole 29 having an inner circumference vertically extending therethrough.
An annular contact surface portion 31 is provided so as to project over the entire circumference of the lower end of the cylindrical fitted portion 30, and a flange 32 is provided so as to extend over the entire circumference in the middle part of the fitted portion 30. I am doing it. In the measurement probe 8 described above, the tip of the probe shaft 24 is formed as a cylindrical rod-shaped fitting portion 33, and the fitting portion 33 is inserted into the through hole 29 of the fitted portion 30 of the probe holder 28. It has a shape and dimensions that fit exactly. The adhesive layer 34 is formed by providing an adhesive tape or the like on the entire lower surface of the annular contact surface portion 31.

By providing the adhesive layer 34 on the entire circumference of the annular contact surface portion 31 as described above, the living body 14 will be described later.
When the probe pedestal 28 is fixed to the surface of the living body 14 with the adhesive layer 34, the lower surface of the probe pedestal 28 can be fixed to the surface of the living body 14 over the entire circumference. Here, when the lower surface of the probe pedestal 28 is not partially fixed to the surface of the living body 14, when the fitting portion 33 of the measurement probe 8 is fitted to the fitted portion 30 of the probe pedestal 28, The probe pedestal 28 may be tilted with respect to the surface of the living body 14, but by fixing the lower surface of the probe pedestal 28 to the surface of the living body 14 over the entire circumference as described above, It does not tilt with respect to the surface of 14.

Further, the probe pedestal 28 can be provided with means for measuring an angle. In the embodiment of FIG. 4, an angle measuring means is formed by attaching a level 35 to the flange 32. The level 35 is provided so that its upper surface is flush with the upper surface of the flange 32. There is. As the level 35, it is possible to use a level formed by enclosing water and bubbles so that the horizontal state can be measured by moving the bubbles to the center.

FIGS. 1 and 5 to 7 show a living body supporting device 43 for supporting the arm portion 14a as the living body 14, and a living body supporting portion 45 is provided on the upper surface of a base 44 to support the living body. A grip bar 46 is provided near one end of the portion 45.
Inclination adjusting screws 56 are provided at the four corners of the base 44, and the inclination adjusting screws 56 are turned to adjust the protruding height from the lower surface of the base 44 so that the base 44 is horizontally adjusted and installed. I am able to do it.

The living body support portion 45 is formed of an angle adjusting plate 47 and a cushion material 48 mounted thereon, and the angle adjusting plate 47 has a lateral angle adjusting plate 47a and a vertical angle adjusting plate 47b at their edges. It is formed by a hinge 51 that is pivotally attached in a vertically rotatable manner. The angle adjusting plate 47 is arranged in the opening 50 of the base 44, and one end of the lateral angle adjusting plate 47a is rotatably attached to the base 44 by a hinge 49 as shown in FIG. is there.
Further, a lateral angle adjusting screw 52 is threaded from the upper surface side to the lower surface side at a side end portion on the side opposite to the side on which the lateral angle adjusting plate 47a is attached by the hinge 49, and a receiving plate provided on the back surface of the base 44. The tip of the lateral angle adjusting screw 52 is brought into contact with the upper surface of 53. Therefore, by rotating the lateral angle adjusting screw 52 so as to project from the lower surface of the lateral angle adjusting plate 47a, the lateral angle adjusting plate 47a is moved from the horizontal state of FIG. 6A to the state shown in FIG. 6B. The lateral angle adjusting plate 47a can be tilted in the lateral direction to adjust the angle. At this time, the entire angle adjusting plate 47 including the vertical angle adjusting plate 47b is horizontally rotated to adjust the angle.

Further, in the vertical angle adjusting plate 47b, the vertical angle adjusting screw 54 is passed from the upper surface side to the lower surface side at the edge portion on the same side as the side on which the horizontal angle adjusting screw 52 is provided on the horizontal angle adjusting plate 47a. It is screwed in, and the tip of the vertical angle adjusting screw 54 is brought into contact with the upper surface of the receiving plate 55 provided on the back surface of the base 44. Therefore, by rotating the vertical angle adjusting screw 54 so as to protrude from the lower surface of the vertical angle adjusting plate 47b, the vertical angle adjusting plate 47b can be moved from the horizontal state to the state shown in FIG.
As in (b), the angle can be adjusted by inclining in the vertical direction.

A vertical angle adjusting plate 47b of the living body support portion 45
A column 57 is provided upright on the base 44 at a position in the vicinity of, and a grip bar 46 is provided on the column 57 so as to project laterally. The grip bar 46 is attached to a slider 59 which is attached to a column 57 so as to be adjustable in vertical position, so that the height of the grip bar 46 can be adjusted. The slider 59 is rotatable around the support column 57, and the grip bar 4
6 can be adjusted to rotate around the support post 57.
Further, the grip bar 46 is attached to a slider 59 so as to be vertically rotatable and tiltable, so that the grip bar 46 can be pivotally adjusted about its axis and the tilt angle can be adjusted. Further, the grip bar 46 is formed in a drum shape so that the fingers except the thumb can be equally gripped, and as shown in FIG. 7A, a positioning pin 60 is provided below the grip bar 46. It is projected. The positioning pin 60 is formed so as to be movable along the longitudinal direction of the grip bar 46 as shown in FIG.

Next, a method and apparatus for measuring a biological signal of the arm 14a of a human body as the living body 14 will be described with respect to the inventions according to claims 1 and 6.

First, the probe pedestal 28 is attached to the arm 14a at the position where the biological signal is measured. The probe pedestal 28 can be attached by adhering it to the surface of the arm 14a with the adhesive layer 34. Next, as shown in FIG. 1, the arm 14a is placed on the cushion material 48 of the living body support portion 45 with the surface on which the probe pedestal 28 is mounted facing up, and the grip bar 46 is gripped by the hand. By gripping the grip bar 46 with the hand in this way, the arm portion 14a is placed on the living body support portion 45.
It is possible to make the position of placing a constant. At this time, as shown in FIG. 7A, the gripping bar 46 is grasped so that the positioning pin 60 is sandwiched between the bases of the forefinger and the middle finger, and the position where the gripping bar 46 is grasped by the hand is made constant. The position at which the arm portion 14a is placed on the living body support portion 45 is made more accurate and constant.

In this way, the arm portion 14 is placed on the living body support portion 45.
After mounting a, the horizontal angle adjustment screw 52 and the vertical angle adjustment screw 5
4 is operated to adjust the inclination angle of the lateral angle adjusting plate 47a of the angle adjusting plate 47 in the horizontal direction as shown in FIG. 6B, and the vertical angle adjusting plate 47b as shown in FIG. 5B. The angle of the surface of the measurement portion of the arm portion 14a is adjusted as shown in FIG. The angle of the surface of the arm portion 14a is adjusted so that the surface of the arm portion 14a is horizontal, and the probe pedestal 2
The surface of the arm portion 14a can be made horizontal by adjusting the angle of the living body support portion 45 while performing the measurement with the level 35 provided in FIG.

Next, the measuring probe 8 is held by hand and the angle of the measuring probe 8 is adjusted. The angle of the measuring probe 8 is adjusted by adjusting the angle of the probe shaft 24 to be vertical, and the inclination of the measuring probe 8 is adjusted so that the level 26 provided in the measuring probe 8 becomes horizontal. As a result, the angle of the measuring probe 8 can be adjusted so that the probe shaft 24 becomes vertical.

Then, while maintaining this state, FIG.
As described above, the fitting portion 33 at the tip of the probe shaft 24 of the measurement probe 8 is inserted into the through hole 29 of the fitted portion 30 of the probe receiving base 28.
8 and pushes the lower end surface of the probe barrel 23 into contact with the upper surface of the flange 32 of the probe holder 28 so that the tip end surface of the probe shaft 24 contacts the surface of the arm portion 14a as shown in FIG. 8B. Can be made. here,
When the lower end surface of the probe barrel 23 is pushed into contact with the upper surface of the flange 32 of the probe pedestal 28, the elastic member 40 is compressed, as shown in FIG. 8C.
The elastic member 40 extends in the direction in which the probe shaft 24 is projected downward.
The probe shaft 24 comes into contact with the surface of the arm portion 14a by the pressure of this elastic force of the elastic member 40.

Thus, the probe shaft 2 of the measuring probe 8
With the tip of 4 in contact with the surface of the arm portion 14a, the light source 1 is caused to emit light as described above, and the surface of the arm portion 14a is irradiated with the measurement light and the reflected light from the living body is received. A signal can be measured.

At this time, when the biological signal is repeatedly measured as described above, the probe pedestal 28 has the arm 1
Since it is attached to the predetermined position of 4a, the measurement point can be positioned and fixed at the point where the probe holder 28 is attached. Further, as described above, since the surface of the arm portion 14a is horizontally angled and the measurement probe 8 is vertically adjusted, the probe shaft 24 of the measurement probe 8 is perpendicular to the surface of the arm portion 14a. Is in contact with, and the angle of the measuring probe 8 with respect to the surface of the arm portion 14a can be made constant. Furthermore, the pressure with which the probe shaft 24 contacts the surface of the arm portion 14a is the biasing force of the elastic member 40, and the contact pressure of the measurement probe 8 can be made constant. Therefore,
Position of measurement point of living body 14, angle of surface of living body 14, angle of measuring probe 8 with respect to surface of living body 14, living body 14
The biological signal can be measured in a state where the contact pressure of the measurement probe 8 on the surface is constant, and the measurement can be performed with high reproducibility without variation in the detection result.

In the above-described embodiment, the probe pedestal 28 is used as a means for positioning the measurement position of the living body 14 by the measurement probe 8 at a predetermined position, but the probe pedestal 28 is used only. Instead of this, a mark may be attached to the surface of the living body 14 with a marker or the like, and the living body signal may be measured by the measuring probe 8 at the position of the mark.

Next, a method and an apparatus for measuring a biological signal of the arm portion 14a of the human body as the living body 14 will be described with respect to the inventions according to claims 2 and 7.

First, the probe pedestal 28 is attached and attached to the arm portion 14a at the biometric signal measurement position in the same manner as described above.
Next, in the same manner as described above, the arm 14a is placed on the living body support portion 45 of the living body support device 43 with the surface on which the probe pedestal 28 is mounted facing up, and the grip bar 46 is gripped by the hand. Next, the fitting portion 33 at the tip of the probe shaft 24 of the measurement probe 8 is inserted into the through hole 29 of the fitted portion 30 of the probe receiving base 28 and fitted therein. In this state, the horizontal angle adjusting screw 52 and the vertical angle adjusting screw 54 are screwed in, and the angle of the living body support portion 45 is adjusted in the same manner as described above. At this time, the measurement probe 8
As shown in FIG. 1, by adjusting the angle of the living body support portion 45 while measuring the angle with one of the level level 26 provided on the probe support 28 and the level level 35 provided on the probe pedestal 28, as shown in FIG. The surface of the arm portion 14a can be made horizontal by adjusting the angle. Then, while keeping this state, the lower end surface of the probe barrel 23 is pushed until it abuts the upper surface of the flange 32 of the probe holder 28 in the same manner as in FIG. 8C, and the probe shaft is pressed by the pressure of the elastic member 40. The tip of 24 is brought into contact with the surface of the arm 14a.
Then, with the tip of the probe shaft 24 of the measurement probe 8 in contact with the surface of the arm portion 14a in this manner, the light source 1 is caused to emit light as described above to irradiate the surface of the arm portion 14a with the measurement light. It is possible to receive reflected light from a living body and measure a biological signal.

Even in this case, the probe pedestal 28 has the arm 1 when repeatedly measuring the biological signal.
Since it is attached to the predetermined position of 4a, the measurement point can be positioned and fixed at the point where the probe holder 28 is attached. Further, as described above, the surface of the arm portion 14a is horizontally adjusted in angle, and the measuring probe 8 is fitted into the probe pedestal 28.
The probe shaft 24 of the measuring probe 8 is in contact with the surface of 4a at a right angle, and the angle of the measuring probe 8 with respect to the surface of the arm portion 14a can be made constant.
Furthermore, the pressure with which the probe shaft 24 contacts the surface of the arm portion 14a is the biasing force of the elastic member 40, and the contact pressure of the measurement probe 8 can be made constant. Therefore, the biological signal is measured with the position of the measurement point of the living body 14, the angle of the surface of the living body 14, the angle of the measuring probe 8 with respect to the surface of the living body 14, and the contact pressure of the measuring probe 8 with respect to the surface of the living body 14 being constant. It is possible to perform the measurement, and it is possible to perform the measurement with high reproducibility without variation in the detection result for each measurement.

It should be noted that in the above-mentioned embodiment, one of the measuring probe 8 and the probe pedestal 28 is provided with a level level 26, 3.
If 5 is provided, it is not necessary to provide the spirit level 26, 35 on the other side.

Next, a method for measuring a biological signal of the arm portion 14a of the human body as the living body 14 will be described with respect to the invention according to claim 3.

First, the probe pedestal 28 is attached and attached to the arm 14a at the measurement position of the biological signal in the same manner as described above.
Next, in the same manner as described above, the arm 14a is placed on the living body support portion 45 of the living body support device 43 with the surface on which the probe pedestal 28 is mounted facing up, and the grip bar 46 is gripped by the hand. In this state, the horizontal angle adjusting screw 52 and the vertical angle adjusting screw 54 are screwed in, and the angle of the living body support portion 45 is adjusted in the same manner as described above. At this time, the level 35 provided on the probe holder 28
By adjusting the angle of the living body support portion 45 while performing the angle measurement with, the angle of the arm portion 14a can be adjusted and the surface of the arm portion 14a can be made horizontal as shown in FIG. Then, while keeping this state, the fitting portion 33 at the tip of the probe shaft 24 of the measurement probe 8 is inserted into the through hole 29 of the fitted portion 30 of the probe receiving base 28 to be fitted, and further, as shown in FIG. ), The lower end surface of the probe barrel 23 is pressed until it contacts the upper surface of the flange 32 of the probe holder 28, and the tip of the probe shaft 24 is brought into contact with the surface of the arm portion 14a by the pressure of the elastic member 40. . The probe shaft 24 of the measurement probe 8 is thus
With the tip of the arm contacting the surface of the arm portion 14a, the light source 1 is caused to emit light as described above, the surface of the arm portion 14a is irradiated with the measurement light, and the reflected light from the living body is received. Can be measured.

Even in this case, the probe pedestal 28 has the arm 1 when repeatedly measuring the biological signal.
Since it is attached to the predetermined position of 4a, the measurement point can be positioned and fixed at the point where the probe holder 28 is attached. Further, as described above, the surface of the arm portion 14a is horizontally adjusted in angle, and the measuring probe 8 is fitted into the probe pedestal 28.
The probe shaft 24 of the measuring probe 8 is in contact with the surface of 4a at a right angle, and the angle of the measuring probe 8 with respect to the surface of the arm portion 14a can be made constant.
Furthermore, the pressure with which the probe shaft 24 contacts the surface of the arm portion 14a is the biasing force of the elastic member 40, and the contact pressure of the measurement probe 8 can be made constant. Therefore, the biological signal is measured with the position of the measurement point of the living body 14, the angle of the surface of the living body 14, the angle of the measuring probe 8 with respect to the surface of the living body 14, and the contact pressure of the measuring probe 8 with respect to the surface of the living body 14 being constant. It is possible to perform the measurement, and it is possible to perform the measurement with high reproducibility without variation in the detection result for each measurement. In the above embodiment, it is not necessary to provide the level 26 on the measuring probe 8.

Here, as shown in FIG. 3 described above, the tip of the irradiation side optical fiber 6 which is the irradiation side light guiding means and the tip of the detection side optical fiber 10 which is the detection side light guiding means are the surface of the living body 14. Although it is arranged so as to be exposed on the tip surface of the measurement probe 8 which is a contact portion to the contact point, the center-to-center distance L between the tip of the irradiation side optical fiber 6 and the tip of the detection side optical fiber 10 is 0.2 to 2 mm. It is preferable to set as follows. If this distance L is large, not only the signal of the dermal tissue but also the signal of the muscle tissue and the fat tissue located thereunder may be detected and the disturbance signal may increase, but this distance L is set to 0. By setting it as small as 2 to 2 mm, it is possible to detect only the signal selectively transmitted through the dermis portion or selectively reflected by the dermis portion, and it is possible to accurately measure a biological signal such as glucose concentration. It is possible.

When measuring the biological signal with the measuring probe 8 as described above, the living body 14 of the measuring probe 8 is used.
By adjusting the temperature of the portion that comes into contact with the surface to the same temperature as the temperature of the surface of the living body 14, there is no variation in the detection results for each measurement, and highly reproducible measurement can be performed.

FIG. 9 shows an apparatus for heating the measuring probe 8 in order to adjust the temperature of the contact portion of the measuring probe 8 to the surface of the living body 14 to the same temperature as the surface temperature of the living body 14.

In the embodiment shown in FIG. 9A, a heater 62 connected to a power supply line 63 is wound around the outer circumference of the tip of the probe shaft 24 of the measuring probe 8. The tip portion can be heated. Further, a temperature sensor 64 such as a thermocouple is provided at the tip of the probe shaft 24, and the heating temperature of the tip of the probe shaft 24 can be controlled by the temperature sensor 64.

In the embodiment shown in FIG. 9B, the probe heat insulating base 65 is used. Probe warming stand 65
A fitting recess 66 for fitting and holding the measurement probe 8 in the
Is recessed, and a heater 62 is provided in the bottom portion of the probe heat insulating base 65. A temperature sensor 64 is provided facing the fitting recess 66. In this case, the fitting recess 66
It is possible to heat the tip of the probe shaft 24 by inserting the measurement probe 8 in such a manner that the tip of the probe shaft 24 is inserted into the probe and heating the heater 62 in this state. The temperature can be controlled.

By heating the tip of the probe shaft 24 of the measurement probe 8 as described above, the temperature of the contact portion of the measurement probe 8 with the surface of the living body 14 is adjusted to the same temperature as the surface temperature of the living body 14. Is something that can be done. Here, since the surface temperature of the living body 14 fluctuates depending on the outside air temperature and the like, if the surface temperature of the living body 14 is kept constant by heating the surface temperature of the living body 14 to a predetermined temperature, the measurement probe 8 It becomes easy to adjust the temperature of the contact portion of the living body 14 to the surface to the same temperature as the surface temperature of the living body 14.

FIG. 10 shows a probe holder 28 used for heating the temperature of the surface of the living body 14, in which a heater 62 is provided on the upper surface of the contact surface portion 31, and a heat insulating material is provided on the heater 62. 67 is provided. A temperature sensor 64 is attached to the lower surface side of the adhesive layer 34 provided on the lower surface of the contact surface portion 31. Other configurations are the same as those in FIG. The probe pedestal 2 is attached by the adhesive layer 34.
By attaching 8 to the surface of the living body 14 and heating the heater 62, the surface of the living body 14 can be heated by the heater 62, and the heating temperature can be controlled by the temperature sensor 64. is there.
In heating the surface of the living body 14 in this manner, the heating temperature of the probe shaft 24 of the measurement probe 8 and the heating temperature of the surface of the living body 14 are set to be equal to each other, so that the measurement probe 8 comes into contact with the surface of the living body 14. It is easy to adjust the temperature of the part and the temperature of the surface of the living body 14 to the same temperature.

Here, when the fitting portion 33 of the probe shaft 24 of the measurement probe 8 is fitted into the fitted portion 30 of the probe holder 28 as described above, if the fitting portion 33 is cylindrical, The probe shaft 24 freely rotates around the fitting in the circumferential direction, and the fitting portion 33 fits into the fitted portion 30 of the probe pedestal 28 at any angle in the circumferential direction. However, as shown in FIG.
When the tip of the irradiation-side optical fiber 6 and the tip of the detection-side optical fiber 10 exposed on the tip surface of the probe are not arranged on the circumference around the center of the probe shaft 24, the fitted portion 30 of the probe holder 28 is If the fitting direction of the fitting portion 33 to the living body 14 is not constant in the circumferential direction of the probe shaft 24,
The contact positions of the tip of the irradiation-side optical fiber 6 and the tip of the detection-side optical fiber 10 with respect to the surface are not constant, and there is a possibility that the detection result will vary from measurement to measurement when measuring a biological signal.

Therefore, in this case, the fitting portion 33 of the probe shaft 24 of the measuring probe 8 is fitted into the fitted portion 30 of the probe holder 28 so as not to rotate in the circumferential direction around the fitting. Is preferred. FIG. 11 shows a probe holder 28.
The fitting part 33 of the measurement probe 8 is fitted to the fitted part 30 of FIG. The detent ring 69 is fixedly attached, and a locking projection 70 is provided at one location on the outer surface of the detent ring 69.
In addition, a locking groove 71 is provided at one location on the inner circumference of the through hole 29 of the fitted portion 30 of the probe holder 28. Then, when the fitting portion 33 of the probe shaft 24 of the measurement probe 8 is fitted into the fitted portion 30 of the probe holder 28, the detent ring 69 is inserted into the fitted portion 30 and the locking groove 7 is inserted.
By inserting and locking the locking projection 70 on the fitting 1, the fitting portion 33 can be fitted into the fitted portion 30 in a non-rotatable manner in the fitting direction.

Next, FIGS. 12 and 13 show the measurement probe 8
As means for contacting the surface of the living body 14 with a predetermined pressure,
It is an example of an embodiment in the case of using the measurement probe 8 provided with the elastic member 40 as described above with reference to FIG. That is, a belt 81 is attached to the probe pedestal 28, and the belt 81 is wound around the living body 14 such as the arm portion 14a, and both ends of the belt 81 are joined by a planar fastener commonly called a magic fastener (R). The probe holder 28 can be fixed to the surface of the living body 14. A ring-shaped coupling plate 83 is attached to the outer periphery of the fitted portion 30 of the probe pedestal 28. On the outer periphery of the connecting plate 83, a pair of lock tools 84 pivotally supported at the central portion and rotated by a seesaw are attached. A lock pawl 85 is provided on the upper end of the lock member 84 projecting upward from the upper surface of the coupling plate 83, and a spring 86 is provided on the lower end thereof, so that the upper portion of the lock member 84 is rotated inward. It is urged to rotate so that Further, an engagement recess 87 into which the lock claw 85 of the lock tool 84 is inserted and engaged is provided on the outer periphery of the lower end portion of the probe body 23 of the measurement probe 8.

In this case, after fixing the probe pedestal 28 to the surface of the living body 14 such as the arm portion 14a with the belt 81 as shown in FIG. 12, the lock tool 84 as shown in FIG. 13 (a).
While pushing the measurement probe 8 downward so as to rotate the upper part of the probe outward, the fitting part 3 at the lower end of the probe shaft 24 is pushed.
3 is inserted into the fitted portion 30 of the probe pedestal 28, and the measurement probe 8 is further pushed downward, the lock claw 85 of the lock tool 84 is inserted and engaged in the engagement recess 87 as shown in FIG. 13B. The measurement probe 8 is coupled and fixed to the probe pedestal 28 via the coupling plate 83 with the lower surface of the probe barrel 23 of the measurement probe 8 abutting on the upper surface of the coupling plate 83. When the measurement probe 8 is pushed downward in this way to bond and fix the measurement probe 8 to the probe holder 28, the elastic member 40 is attached to the probe shaft 24 in the direction in which it is projected downward by the elastic member 40 as described above. As shown in FIG. 8C, the tip end surface of the probe shaft 24 is in contact with the surface of the living body 14 at a predetermined constant pressure, as in the case of FIG. 8C.

Here, in the case of FIG. 8C, it is necessary to support and press the measuring probe 8 with a force that opposes the elastic force of the elastic member 40. When the force pressed by is larger than the force that resists the elastic force of the elastic member 40, the contact pressure of the probe shaft 24 with respect to the surface of the living body 14 also increases, and the contact pressure may fluctuate. On the other hand, by connecting and fixing the measurement probe 8 to the probe pedestal 28 via the connecting plate 83 as described above, it is not necessary to support and press the measurement probe 8 by hand, and the contact pressure is also reduced. Can be prevented from fluctuating. Further, when the probe pedestal 28 is fixed to the surface of the living body 14, when it is fixed by adhering it with the adhesive layer 34 as described above, the elastic force of the elastic member 40 causes the adhesive layer 34 to adhere to the surface of the living body 14. It acts in the direction of peeling from the
It may not be possible to stably fix the probe pedestal 28 on the surface of the living body 14, but by fixing the probe pedestal 28 to the surface of the living body 14 by winding the belt 81 as described above, such a problem is eliminated. .

Next, in FIG. 14, the probe shaft 24 of the measuring probe 8 is used without using the biasing means such as the elastic member 40.
2 shows an example of an embodiment in which the tip of the above can be brought into contact with the surface of the living body 14 at a predetermined constant pressure. That is, the measurement probe 8 is mounted in the slide outer cylinder 73 so as to be vertically slidable.
When the probe is slid downward, the probe shaft 24 of the measurement probe 8 is inserted through the opening 74 provided on the lower surface of the slide cylinder 73.
The lower end of the is projected downward. Further, a lock member 75 pivotally supported at the central portion and rotated by a seesaw is attached to the outer surface of the slide outer cylinder 73. A lock claw 76 is projected from one end of the lock tool 75 and a spring 77 is attached to the other end, and the lock claw 76 is inserted into the slide cylinder 73 through a lock hole 78 formed in the slide cylinder 73. The lock 75 is biased to rotate.
An engaging recess 79 is provided on the outer periphery of the measuring probe 8, and the locking claw 76 is provided in the engaging recess 79 in a state where the measuring probe 8 is pulled up so that the lower end of the probe shaft 24 retracts into the slide outer cylinder 73. The measurement probe 8 can be held in this pulled-up state by being engaged.

In this case, after the probe pedestal 28 is attached and fixed to the surface of the living body 14, the lower surface of the slide outer cylinder 73 is attached to the upper surface of the flange 32 of the probe pedestal 28 as shown in FIG. 14A. 14A, and then the locking tool 75 is rotated so as to compress the spring 77, and the locking claw 76 is removed from the engaging recess 79 as shown in FIG. 14B. The inside slides and falls by its own weight, the fitting portion 33 of the probe shaft 24 is inserted into the engaged portion 30 of the probe receiving base 28, and the tip end surface of the probe shaft 24 contacts the surface of the living body 14. Therefore, in this device, the tip of the probe shaft 24 comes into contact with the surface of the living body 14 due to the own weight of the measuring probe 8, and the contact pressure of the tip of the probe shaft 24 against the surface of the living body 14 is constant due to the own weight of the measuring probe 8. It can be pressure.

FIG. 15 shows another example of the embodiment of the living body supporting apparatus 43. A marking plate 89 is provided on the upper surface of the lateral angle adjusting plate 47a of the angle adjusting plate 47 constituting the living body supporting portion 45. , A pair of indicators 9 on the marking plate 89
0 is formed. A marking pin 91 is provided on the upper surface of the vertical angle adjusting plate 47b. Reference numeral 92 denotes an elbow pad provided on the upper surface of the lateral angle adjusting plate 47a.

In this case, the arm portion 14a is placed on the living body supporting portion 45 of the living body supporting device 43, and the grip bar 4 is held by hand.
6 is gripped, one side of the arm 14a is aligned with the marking plate 89 and the marking pin 91, and the index 90 of the marking plate 89 is held.
Marking lines 91a, 93b, 93c are inserted in the arm portion 14a in alignment with the marking pins 91. Therefore, when the measurement of the biological signal is repeatedly performed, the marking lines 93a, 93b, 93c are aligned with the index 90 and the marking pin 91 of the marking plate 89 each time, so that the arm portion 14a is placed on the living body support portion 45. The position to put on is always constant.

FIG. 16 shows an apparatus in which the measuring probe 8 is automatically moved up and down.
5, a column 96 is erected upright, and the column 96 is adjustable in angle between a vertical state and a state of inclining to the left and right. The tilt angle of the support column 96 is displayed by the pointer 102. Further, an elevating body 97 that is vertically moved along the supporting column 96 by a cylinder device or the like is provided on the supporting column 96, and a horizontal rail 98 in the horizontal direction is attached to the elevating body 97. A lateral moving body 99 that is moved along the lateral rail 98 by a motor or the like is attached to the lateral rail 98, and the measuring probe 8 is attached to the lateral moving body 99. In this case, after adjusting the angle of the measuring probe 8 by the inclination of the support column 96, the lateral moving body 99 is moved so that the measuring probe 8 is located directly above the probe pedestal 28 mounted on the surface of the living body 14. After that, as shown in FIG. 16B, the elevating body 97 is moved downward to fit the probe shaft 24 of the measurement probe 8 into the probe holder 28, thereby measuring the biological signal with the measurement probe 8. Is something that can be done.

In the embodiment shown in FIG. 17, an X-axis body 100 is provided which is vertically driven along the support column 96, and the Y-axis body 10 which is laterally driven along the X-axis body 100 is provided.
1 is provided so as to be orthogonal to the X-axis body 100. The measurement probe 8 is provided so as to be laterally driven along the Y-axis body 101, and the probe mounted on the surface of the living body 14 by moving the measurement probe 8 in the X-axis direction and the Y-axis direction. The measuring probe 8 is provided directly on the pedestal 28.
The position can be accurately and easily aligned.

[0066]

The invention will now be illustrated by the examples.

(Example) As shown in FIG. 9B, the tip portion of the probe shaft 24 of the measurement probe 8 was heated to 35 ° C. by the probe heat insulating base 65, and the probe receiving base 28 was formed as shown in FIG. Using a heater with a simple heater 62, the surface of the arm 14a was warmed to 35 ° C. by sticking it to the surface of the arm 14a at an intermediate point between the elbow and the wrist with an adhesive layer 34.

Next, as shown in FIG. 1, the arm portion 14a is placed on the living body supporting portion 45 of the living body supporting device 43, and the lateral angle adjusting screw 52 is attached.
The angle of the living body support portion 45 was adjusted by operating the screwing of the vertical angle adjusting screw 54 and performing the measurement with the level 35 provided on the probe pedestal 28, thereby leveling the surface of the arm portion 14a. In this state, as shown in FIG. 15, lines 93a, 93b, 93c are attached to the arm 14a in accordance with the index 90 and the marking pin 91 of the marking plate 89, and from the next time, the line 90a and the marking pin 91 of the marking plate 89 will be marked. The arm portion 14a is placed on the living body support portion 45 by combining 93a, 93b, and 93c.

Next, by holding the measuring probe 8 in hand and adjusting the inclination of the measuring probe 8 so that the level 26 becomes horizontal, the angle of the measuring probe 8 is adjusted so that the probe shaft 24 becomes vertical. Was done. Then, while keeping this state, the fitting portion 33 of the tip portion of the probe shaft 24 of the measuring probe 8 is inserted into the fitted portion 30 of the probe pedestal 28 and pushed in, as shown in FIG. 8B. The tip surface of the probe shaft 24 was brought into contact with the surface of the arm portion 14a.

In this way, with the tip of the probe shaft 24 of the measurement probe 8 in contact with the surface of the arm portion 14a, the light source 1 is caused to emit light and the measurement wavelength range from 1200 to 1950 nm.
Irradiates the measurement light of and receives the reflected light from the living body,
The biological signal was measured and the absorption spectrum was taken.

Then, the above-mentioned steps 1 to 3 were repeated at intervals of 5 minutes, and the biological signal was measured 50 times. This 50
FIG. 18 (a) shows an overlay spectrum of each absorption spectrum of one measurement, which is overlaid on one chart.

(Comparative Example) A mark was made on the surface of the arm 14a at the midpoint between the elbow and the wrist, and the probe shaft 24 of the measuring probe 8 was pressed against this mark, and the biological signal was measured in this state. Then, this measurement at the position of this mark was performed 50 times. FIG. 18 (b) shows a chart in which the absorption spectra obtained by the 50 measurements are overwritten.

In the chart of FIG. 18 (b), the absorption spectra of 50 measurements were scattered, and the reproducibility of the measurement results was poor. However, in the case of this example, FIG.
As can be seen from the chart of (a), the absorption spectra of 50 measurements were almost overlapped as one line, and it was confirmed that the reproducibility of the measurement results was good.

[0074]

As described above, in the biological signal measuring method according to the first aspect of the present invention, the measuring probe is brought into contact with the surface of the living body, the measuring light is irradiated onto the surface of the living body, and the reflected light from the living body is received, In the biological signal measuring method adapted to measure the biological signal from the light receiving component, the step of adjusting the biological surface to a predetermined angle while measuring the angle of the biological surface, the measurement probe at a predetermined angle while measuring the angle of the measuring probe. The step of adjusting, contacting the measurement probe at a predetermined position on the surface of the living body with a predetermined pressure in a state where the angle between the living body surface and the measuring probe is adjusted, in this state, irradiating the living body surface with the measuring light from the measuring probe and reflecting light. Since it consists of the step of receiving light, the angle of the living body surface, the angle of the measuring probe, the contact position of the measuring probe with respect to the living body surface, and the contact pressure of the measuring probe are kept constant. And are those that can be measured in biological signal in a state without the detection result varies for each measurement, it is capable of performing highly reproducible measurement.

The biological signal measuring method according to claim 2 of the present invention is such that the measuring probe is brought into contact with the surface of the living body, the measuring light is irradiated onto the surface of the living body, and the reflected light from the living body is received. In the biological signal measuring method adapted to measure, the step of fixing the probe pedestal at a predetermined position on the biological surface, the step of fitting the measurement probe to the probe pedestal, the angle of at least one of the probe pedestal and the measurement probe Adjusting the angle of the living body surface so that the measuring probe is at a predetermined angle while measuring, contacting the measuring probe with a predetermined pressure on the living body surface while holding the measuring probe at this predetermined angle, in this state The step of irradiating the measuring light from the measuring probe and receiving the reflected light, so that the angle of the living body surface, the angle of the measuring probe, the living body surface The biological signal can be measured with the contact position of the measuring probe and the contact pressure of the measuring probe kept constant, and highly reproducible measurement can be performed without variations in the detection results for each measurement. It is possible.

According to a third aspect of the present invention, there is provided a biological signal measuring method in which a living body surface is brought into contact with a measuring probe, the living body surface is irradiated with measuring light and reflected light from the living body is received. In the biological signal measuring method adapted to measure the step of fixing the probe pedestal to a predetermined position on the surface of the living body, while measuring the angle of the probe pedestal, the angle of the biological surface is adjusted so that the probe pedestal has a predetermined angle. Adjusting step, fitting the measurement probe to the probe pedestal while holding the probe pedestal at this predetermined angle, contacting the measurement probe with a predetermined pressure on the living body surface, in this state from the measurement probe to the living body surface The step of irradiating the measurement light and receiving the reflected light, since it consists of the angle of the biological surface, the angle of the measurement probe, the contact position of the measurement probe to the biological surface, Are those in a state in which the contact pressure constant probe constant can be measured in the biological signal, without detection result varies for each measurement, it is capable of performing highly reproducible measurement.

The invention according to claim 4 is the measuring probe according to any one of claims 1 to 3, wherein the measurement probe guides and irradiates the measurement light from the light source, and the reflection light reflected by the living body. The irradiation side light guide means and the detection side light guide means each have a center-to-center distance of a contact portion between the irradiation side light guide means and the detection side light guide means of 0.2 to. 2 mm
Since they are arranged at intervals of, it is possible to detect only the signals that are selectively transmitted through the dermis and selectively reflected by the dermis, and it is possible to accurately measure biological signals such as glucose concentration. Is something that can be done.

Further, in the invention of claim 5 according to any one of claims 1 to 4, the temperature of the contact portion of the measuring probe with the living body surface is heated so as to be the same as the temperature of the living body surface. It is possible to prevent the detection result from fluctuating due to the change of, and it is possible to perform the measurement with high reproducibility without causing variation in the detection result for each measurement.

A biological signal measuring device according to claim 6 of the present invention.
Touch the surface of the living body with a measuring probe to measure the surface of the living body.
It emits a constant light and receives the reflected light from the living body.
Biological signal measurement that measures the biological signal from the received light component
Position the measurement point on the surface of the living body at a predetermined position
Measure the angle of the measuring point on the surface of the living body
Means, a means for measuring the angle of the measuring probe, and a measuring probe.
A hand that brings the lobe into contact with the measurement point on the surface of the living body at a specified pressure
Since it has a step, the angle of the living body surface, the measurement probe
Angle, contact position of the measuring probe with the biological surface,
Measurement of biological signals with the contact pressure of the constant probe kept constant
The measurement result can be determined for each measurement.
It is possible to perform highly reproducible measurements without variation.
It is possible.

According to a seventh aspect of the present invention, a biological signal measuring device contacts a living body surface with a measuring probe, irradiates the living body surface with measuring light and receives reflected light from the living body. In a biological signal measuring device configured to measure, a measurement probe having a fitting portion, and a fitting portion to which the fitting portion of the measurement probe is fitted and used by being fixed to a predetermined position on the living body surface is provided. Since the probe pedestal, means for measuring the angle of at least one of the probe pedestal and the measurement probe, and means for bringing the measurement probe into contact with the living body surface at a predetermined pressure, the angle of the living body surface, the angle of the measuring probe It is possible to measure a biomedical signal with the contact position of the measurement probe on the surface of the living body and the contact pressure of the measurement probe being constant, and the detection result varies from measurement to measurement. Without a, it is capable of performing highly reproducible measurement.

According to an eighth aspect of the present invention, in the seventh aspect, the fitting portion of the measurement probe is formed in a rod shape, and the fitting portion of the probe pedestal has a shape in which the rod-shaped fitting portion is inserted and fitted. Since it is formed in a cylindrical shape with a through hole, by inserting the fitting part into the fitted part and fitting it, the measurement probe can be fitted to the probe pedestal at a predetermined constant angle. It is possible to perform highly reproducible measurement in a state in which the angle of the measuring probe with respect to the human body surface is kept at a predetermined angle by the probe holder fixed to.

According to a ninth aspect of the present invention, in the eighth aspect, the tubular contact surface of the fitting portion formed in the cylindrical shape of the probe holder with the living body surface is adhered to the living body surface over the entire circumference. By doing so, the lower surface of the probe pedestal can be fixed to the living body surface over the entire circumference, and the probe pedestal can be prevented from tilting with respect to the living body surface.

Further, the invention of claim 10 is the invention of claim 8 or 9.
In the above, since the fitting portion of the measurement probe is non-rotatably fitted to the fitted portion of the probe pedestal in the direction around the fitting, the tip of the irradiation side optical fiber and the detection side optical fiber with respect to the living body surface are The contact position of the tip can be made constant, and highly reproducible measurement can be performed.

Further, the invention of claim 11 relates to claims 6 to 1.
In any one of 0, since the measurement probe is provided with a biasing means for biasing the measurement probe toward the surface of the living body as a means for bringing the measurement probe into contact with the surface of the living body at a predetermined pressure, the measurement is performed with a simple configuration using the biasing means. The probe can be brought into contact with the surface of the living body at a predetermined pressure to perform highly reproducible measurement.

Further, the invention of claim 12 relates to claims 6 to 1.
In any one of 1, the living body is a subject's arm, and a living body support portion that supports the arm portion so that the angle can be adjusted, and a grip bar that is arranged at one end edge of the living body support portion and held by the subject's hand, Since it is provided, the angle of the surface of the arm portion can be easily adjusted, and the position where the arm portion is placed on the living body support portion can be made constant by the grip bar, and highly reproducible measurement can be performed. .

[Brief description of drawings]

FIG. 1 is a front view showing an example of an embodiment of the present invention.

FIG. 2 shows an example of the above-mentioned measurement probe,
(A) is a front view and (b) is a sectional view.

3A and 3B show an example of a probe shaft of the above-mentioned measurement probe, FIG. 3A is a cross-sectional view, FIG. 3B is an enlarged view of the tip surface of the probe shaft, and FIG. It is an enlarged view of the example of.

FIG. 4 shows an example of the probe pedestal of the above,
(A) is a perspective view and (b) is a sectional view.

FIG. 5 shows an example of the biological support device of the above,
(A) is a plan view, (b) is a front view, and (c) is a side view.

6 (a) and 6 (b) are enlarged side sectional views of the biological support device of the above.

FIG. 7 is a view showing an example of a grip portion of the biological support device of the above, and (a) and (b) are front views, respectively.

8A and 8B show measurement of a biological signal using the above-described probe pedestal and a measurement probe, wherein FIGS. 8A and 8B are partially cutaway front views, and FIG. 8C is a sectional view.

9A and 9B show another embodiment of a measurement probe, FIG. 9A is a front view of the example, and FIG. 9B is a cross-sectional view of the other example.

FIG. 10 is a cross-sectional view showing another embodiment of the probe pedestal.

FIG. 11 shows another embodiment of the measurement probe and the probe pedestal, (a) is a front view of the measurement probe,
(B) is a bottom view of the measurement probe, and (c) is a perspective view of the probe pedestal.

FIG. 12 is a cross-sectional view showing another embodiment of the measurement probe and the probe pedestal.

FIG. 13 shows the measurement probe and the probe pedestal of the same as above, and (a) and (b) are cross-sectional views of the usage state, respectively.

FIG. 14 shows another embodiment of the measurement probe, wherein (a) and (b) are cross-sectional views, respectively.

FIG. 15 is a perspective view showing an example of another embodiment of the biological support device.

FIG. 16 shows an example of an apparatus for driving a measurement probe, and (a) and (b) are perspective views respectively.

FIG. 17 is a perspective view showing another example of the device for driving the measurement probe.

FIG. 18A is a chart in which absorption spectra of 50 times of measurement in the example are overwritten, and FIG. 18B is a chart in which absorption spectra of 50 times of measurement in the comparative example are overwritten.

FIG. 19 is a schematic diagram showing a biological signal measurement system.

[Explanation of symbols]

1 light source 6 Irradiation side optical fiber 8 Measuring probe 10 Detection side optical fiber 14 living body 14a Arm 26 spirit level 28 Probe stand 29 through holes 30 Fitted part 31 Contact surface 33 Fitting part 34 Adhesive layer 35 level 40 elastic member 43 Biological support device 45 Biological support 46 grip stick

Claims (12)

[Claims] 1. A biological signal measuring method in which a measuring probe is brought into contact with the surface of a living body, the surface of the living body is irradiated with measuring light, and reflected light from the living body is received, and a living body signal is measured from the received light component. Adjusting the body surface to a predetermined angle while measuring the angle of the body surface, adjusting the measurement probe to a predetermined angle while measuring the angle of the measurement probe, measuring probe with the angle of the body surface and the measurement probe adjusted And a step of irradiating the living body surface with measuring light from the measuring probe and receiving reflected light in this state. 2. A biological signal measuring method in which a measuring probe is brought into contact with the surface of a living body, measuring light is irradiated onto the surface of the living body, reflected light from the living body is received, and a living body signal is measured from the received light component, Fixing the probe pedestal to a predetermined position on the surface of the living body, fitting the measurement probe to the probe pedestal, and measuring the angle of at least one of the probe pedestal and the measurement probe so that the measurement probe has a predetermined angle Adjusting the angle of the living body surface, contacting the measuring probe to the living body surface with a predetermined pressure while holding the measuring probe at this predetermined angle, irradiating the living body surface with the measuring light from the measuring probe and reflecting light A method for measuring a biological signal, which comprises a step of receiving light. 3. A biological signal measuring method in which a measuring probe is brought into contact with the surface of a living body, measuring light is irradiated onto the surface of the living body, reflected light from the living body is received, and a living body signal is measured from the received light component. Fixing the probe pedestal at a predetermined position on the surface of the living body, adjusting the angle of the living body surface so that the probe pedestal has a predetermined angle while measuring the angle of the probe pedestal, and setting the probe pedestal to this predetermined angle. Fitting the measurement probe to the probe cradle while holding it, contacting the measurement probe with the living body surface at a predetermined pressure, and irradiating the living body surface with the measuring light from the measuring probe and receiving the reflected light in this state A method for measuring a biological signal, comprising: 4. An irradiation side light guide means for guiding and irradiating the measurement light from a light source, and a detection side light guide means for receiving the reflected light reflected by the living body and guiding it to the light receiving means. And the irradiation-side light guide means and the detection-side light guide means are arranged such that the center-to-center distance between the contact portions to the living body surface is 0.2 to 2 mm. The biological signal measuring method according to claim 1. 5. The biological signal according to claim 1, wherein the temperature of the contact portion of the measuring probe with the living body surface is heated so as to be the same as the temperature of the living body surface. Measuring method. 6. A biological signal measuring device, wherein a measuring probe is brought into contact with the surface of a living body, the measuring light is irradiated onto the surface of the living body, reflected light from the living body is received, and a living body signal is measured from the received light component. Means for positioning the measurement point on the biological surface at a predetermined position, means for measuring the angle of the measurement point on the biological surface, means for measuring the angle of the measurement probe, and contacting the measurement probe with a predetermined pressure on the measurement point on the biological surface A biological signal measuring device, comprising: 7. A biological signal measuring device, wherein a measuring probe is brought into contact with the surface of a living body, the surface of the living body is irradiated with measuring light, reflected light from the living body is received, and a living body signal is measured from the received light component. A measurement probe having a fitting portion, a probe pedestal having a fitted portion to which the fitting portion of the measurement probe is fixed and used at a predetermined position on the living body surface, and a probe pedestal and a measurement probe. A biological signal measuring device comprising: a means for measuring at least one angle; and a means for bringing a measuring probe into contact with the surface of a living body at a predetermined pressure. 8. The fitting portion of the measuring probe is formed in a rod shape,
8. The biological signal measuring device according to claim 7, wherein the fitted portion of the probe pedestal is formed in a tubular shape having a through hole into which the rod-shaped fitting portion is inserted and fitted. 9. The tubular contact surface of the fitting portion formed in the cylindrical shape of the probe holder with the living body surface is adhered to the living body surface over the entire circumference. Item 10. The biological signal measurement device according to item 8. 10. The fitting portion of the measuring probe is fitted into the fitting portion of the probe pedestal so as not to rotate in the direction around the fitting, according to claim 8 or 9. The biological signal measuring device described. 11. The urging means for urging the measuring probe toward the surface of the living body as means for bringing the measuring probe into contact with the surface of the living body at a predetermined pressure. The biological signal measuring device according to claim 1. 12. A living body is an arm of a subject, and a living body support portion that supports the arm portion so that an angle can be adjusted, and a grip bar that is arranged at one end edge of the living body support portion and can be gripped by the subject's hand. The biological signal measuring device according to any one of claims 6 to 11, wherein the biological signal measuring device comprises: