JP2002244089A - Liquid agent for contact lens and treating solution using the same - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a liquid agent for a contact lens which is antiseptic-free, nevertheless has a sufficient antiseptic effect and has a function excellent in the cushion properties between the cornea and the contact lens. SOLUTION: This liquid agent for the contact lens contains (A) at least one kind selected from the group consisting of boric acid or its salt and tris(hydroxymethyl)aminomethane, (B) a metal chelating agent and (C) a viscous agent and has a pH of 6.0 to 8.5, an osmotic pressure of 100 to 600 mMsm, and a dynamic viscosity of 0.9 to 10,000 mm2/s.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a contact lens solution having a sufficient preservative effect as a preservative solution for contact lenses and also having a function as a contact lens rinsing solution. Further, the present invention relates to a contact lens solution that can be used as a diluting solution for a contact lens cleaning agent or a contact lens mounting solution.

[0002]

2. Description of the Related Art Contact lenses are roughly classified into two types: non-hydrous contact lenses and hydrous contact lenses. Of these, non-hydrated contact lenses are
It is classified into hard contact lenses including oxygen permeable hard contact lenses and non-hydrous soft contact lenses.

[0003] Irrespective of whether the contact lens is non-water-containing or water-containing, when worn on the eye, not only proteins derived from tear components, lipids derived from eye oils, etc., but also stains derived from cosmetics and the like adhere. . Therefore, it is necessary to remove those stains after wearing and secure a good visual field when the contact lens is re-mounted.

[0004] At present, contact lens cleaning methods include finger rubbing using a cleaning agent containing an abrasive,
A method using a detergent containing a liquid protease is known. As these prior arts, for example, Japanese Patent Publication No. 5-77047 discloses that a mixture of a water-miscible organic liquid and water in a mixing ratio of 50:50 to 75:25 and a protease are contained. Japanese Unexamined Patent Publication (Kokai) No. 4-93919 discloses a cleaning solution for contact lenses, which comprises at least 20% by weight of a polyhydric alcohol and a protease derived from Bacillus subtilis liquid culture. ing. These liquid detergents containing proteolytic enzymes are usually used after being diluted with a solution called a diluent. After washing, in the case of hydrous contact lenses, sterilize the contact lenses,
Finally, the contact lens is rinsed with a rinsing liquid or the like and attached to the eyes. If not worn immediately, the contact lenses can be stored in a sterilized state. On the other hand, in the case of a non-water-containing contact lens, it is not necessary to sterilize the lens due to the nature of the lens. If the lens is not to be mounted immediately, store the lens with the mixed solution or preservation solution after washing.

[0005] Acanthamoeba keratitis is one of the infectious diseases in which the use of contact lenses is one of the factors. Since Acanthamoeba keratitis was first reported in the United States in 1975, the number of reports has been increasing year by year, and in recent years, attention has been paid to its relevance to contact lens wearing. There is a concern about the use of tap water or well water as one of the reasons for infection of contact lens wearers, and there are many cases of infection caused by rinsing and storing contact lenses with tap water or the like. For example, out of 39 patients with Acanthamoeba keratitis, 35 cases are contact lens wearers, including 23% of non-aqueous contact lens wearers who treat contact lenses using tap water. (Nikkeikai, Vol. 99, pp. 68-75, 19
1995). Therefore, products that offer the preservation and rinsing of non-hydrated contact lenses are also on sale, but they are
It does not have a sufficient preservative effect when it contains a preservative that may cause eye damage or is used as a preservative solution.

[0006] Further, non-hydrous contact lenses are attached to the eyes after rinsing with a rinsing liquid or tap water, but commercially available rinsing preparations and tap water have a cushioning property between the cornea and the contact lenses. It is bad, and often gives a feeling of discomfort usually referred to as "roughness". Therefore, a method has been provided in which a contact lens mounting liquid is dropped onto a contact lens that has been rinsed and then mounted on an eye. However, a contact lens which is preservative-free and has a function as a preservative solution for contact lenses having an antiseptic effect, and which can be used as a contact lens rinsing solution having a good cushioning property between the cornea and the contact lens. No solution has been provided yet.

[0007]

SUMMARY OF THE INVENTION A first object of the present invention is to provide a preservative-free solution having a sufficient preservative effect as a preservative for a contact lens (particularly a non-water-containing contact lens), An object of the present invention is to provide a solution for contact lenses that also has a function as a rinsing liquid. The contact lens solution according to the present invention, a contact lens storage solution, a contact lens rinsing solution,
A general term for a diluent for contact lenses and a liquid agent having a function as a mounting solution for contact lenses when the contact lenses are mounted on eyes. Another object of the present invention is to improve the cushioning property between a contact lens and a cornea, which is one of the causes of poor wearing of a contact lens (particularly, a non-water-containing contact lens), and to function as a contact lens rinsing liquid. The object of the present invention is to provide a contact lens solution having the following.

[0008]

According to the present invention, the above objects and advantages of the present invention are achieved by the following. (1) (A) at least one selected from the group consisting of boric acid or a salt thereof and tris (hydroxymethyl) aminomethane, (B) a metal chelating agent, and (C)
It contains a thickener and has a pH of 6.0 to 8.5 and an osmotic pressure of 100 to 600 mOsm. And the kinematic viscosity is 0.9-1
A liquid formulation for contact lenses, wherein the liquid formulation has a thickness of 000 mm ² / s. (2) The contact lens solution according to the above (1), which is a preservation solution and / or a rinsing solution for the contact lens. (3) The contact lens solution according to the above (1) or (2). 1 to 1 for contact lens cleaning agent 1
A mixed solution mixed so as to have a volume ratio of 00,
The pH of the mixture is 5.0 to 9.0 and the osmotic pressure is 100
-10,000 mOsm. A treatment solution for contact lenses, characterized in that: (4) The contact lens cleaning agent contains at least one selected from the group consisting of a protease, a non-reducing polyhydric alcohol, an alkali metal salt of boric acid, a reducing agent and an anionic surfactant. The treatment solution for contact lenses according to the above (3), which is characterized in that: (5) In any one of the above (1) to (4),
A contact lens solution or a contact lens treatment solution, wherein the target contact lens is a non-hydrated contact lens.

[0009]

BEST MODE FOR CARRYING OUT THE INVENTION At least one (A) selected from the group consisting of boric acid or a salt thereof and tris (hydroxymethyl) aminomethane blended in the liquid preparation of the present invention has a buffering ability and a preservative effect. Component, boric acid is present in the formulation in an amount of 0.001 to 10.0 (w /
v)%, preferably 0.01 to 5.0 (w / v)%, more preferably 0.1 to 2.0 (w / v)%. Examples of borates include borax, potassium borate, and the like.
01 to 10.0 (w / v)%, preferably 0.01 to
It is blended in a range of 5.0 (w / v)%. Also, tris (hydroxymethyl) aminomethane is contained in the preparation at 0.0
01 to 10.0 (w / v)%, preferably 0.01 to
It is blended in a range of 5.0 (w / v)%. When these are mixed and compounded, a total of 0.001
~ 20 (w / v)%, preferably 0.01 ~ 10 (w / v)
v) It is blended in the range of%.

Examples of the metal chelating agent (B) to be mixed in the liquid preparation of the present invention include polycarboxylic acids and / or salts thereof, and polyphosphoric acids and / or salts thereof. Specifically, the former is ethylenediaminetetraacetic acid, citric acid, gluconic acid, tartaric acid, succinic acid, malonic acid, maleic acid and their sodium or potassium salts and the like, and the latter is pyrophosphate, triphosphate, tetraphosphate, Trimetaphosphoric acid, tetrametaphosphoric acid, and sodium or potassium salts thereof, among which disodium ethylenediaminetetraacetate is particularly preferred. The purpose of blending the metal chelating agent is to remove the complex between the inorganic salt such as calcium salt and the protein in the tear fluid adhering to the surface of the contact lens, and to remove boric acid and / or tris (hydroxy). It also has the property of enhancing the preservative effect by coexisting with (methyl) aminomethane (A). The metal chelating agent is contained in the preparation in an amount of 0.001 to 10 (w / v).
%, Preferably in the range of 0.01 to 1.0 (w / v)%.

The liquid preparation of the present invention is preservative by blending at least one of the above-mentioned boric acid or a salt thereof and tris (hydroxymethyl) aminomethane (A) and a chelating agent (B). Although it is agent-free and has a sufficient preservative effect, polylysine, particularly ε-polylysine, can be added as a measure against Acanthamoeba infection. When polylysine is blended, it is blended in the preparation in the range of 0.01 ppm to 2 (w / v)%, preferably 0.1 ppm to 0.01 (w / v)%.

[0012] In order to improve the cushioning property between the contact lens and the cornea, the liquid preparation of the present invention further contains a viscous agent as an essential component. As a thickener,
For example, hydroxyethylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose
Examples include sodium, polyvinylpyrrolidone, methylcellulose, polyvinyl alcohol, carboxyvinyl polymer, glycerin, polyethylene glycol, sorbitol, mannitol, sucrose, chondroitin sulfate, and salts thereof. In vitro, when the slip property of the contact lens was evaluated for the liquid preparation of the present invention, hydroxyethyl cellulose, polyvinylpyrrolidone, and hydroxypropylmethyl cellulose were good among the above-mentioned viscous agents. In addition, the liquid preparations rarely felt the "sticky feeling", and showed the best results in the sensory test results when touched and instilled. The thickener is contained in the preparation at 0.00001 to 2.0 (w /
v)%, preferably 0.0001 to 1.0 (w / v)
%, More preferably 0.01 to 0.5 (w / v)%. The kinematic viscosity of the liquid preparation is 0.9 to 10,000 mm ² / s, preferably 1.
5~350mm ² / s, more preferably 2.0 to 10
It is adjusted to a range of 0 mm ² / s. When the kinematic viscosity is higher than this range, it is not preferable because the liquid is difficult to be discharged from the container containing the liquid, and when the kinematic viscosity is lower than this range, the wearing feeling of the contact lens treated with the liquid is used. Is not preferred because it becomes worse. Here, the “kinematic viscosity” of the liquid preparation is a value measured according to the first method described in the 13th revised Japanese Pharmacopoeia General Test Method “Viscosity Measurement Method”. The liquid preparation of the present invention may further appropriately contain hyaluronic acid or a salt thereof, trehalose, or the like as a substance for imparting hydrophilicity to the contact lens.

The liquid preparation of the present invention is sometimes used as a rinsing liquid for contact lenses. In this case, the liquid preparation enters the eye as it is, and therefore is preferably isotonic with tears. That is, the osmotic pressure of the liquid agent is 100 to 600 mOsm. ,
Preferably 200 to 400 mOsm. Is preferably within the range. Therefore, salts such as sodium chloride and potassium chloride are used as isotonic agents in an amount of 0.01 to 5.0 (w /
v) It can be blended in the range of%. As a tonicity agent, a non-reducing polyhydric alcohol can be blended in place of salts. Examples of the non-reducing polyhydric alcohol include glycerin, ethylene glycol, polyethylene glycol, propylene glycol, polypropylene glycol, sorbitol, mannitol, polyvinyl alcohol, and the like, and one or more of them can be appropriately blended. . When a non-reducing polyhydric alcohol is blended, 0.9 to 5.4 (w / v)
%, Preferably in the range of 1.8 to 3.6 (w / v)%. In addition, the pH of the preparation is directly in the eye as in the case of the osmotic pressure. Therefore, the pH is preferably in the range of 6.0 to 8.5. .

In the liquid preparation of the present invention, a surfactant can be further added as necessary. Since the solution may enter the eye directly, it is preferable to incorporate a nonionic surfactant that does not irritate the eyes, but other amphoteric, cationic and anionic surfactants are also preferred. If the irritation can be alleviated, it is possible to sufficiently mix. Examples of preferred nonionic surfactants include polyoxyethylene-polyoxypropylene block copolymer, polyoxyethylene alkyl ether, polyoxyethylene alkylphenyl ether, polyoxyethylene sorbitan alkyl ester, and polyoxyethylene hydrogenated castor oil. And fatty acid monoglycerides, propylene glycol fatty acid esters, fatty acid sucrose esters and polyoxyethylene-polyoxypropylene ethylenediamine condensates. When these surfactants are blended, they are preferably blended in the preparation in the range of 0.1 ppm to 5 (w / v)%.

The liquid preparation of the present invention is preferably an aqueous solution. In the liquid preparation of the present invention, components other than the thickener are dissolved in an appropriate amount of water and heated at about 80 ° C. to completely dissolve each component. Thereafter, after the mixed solution is sufficiently cooled, a viscous agent is blended, and the volume is adjusted again with water, whereby it can be industrially advantageously prepared.

The liquid preparation of the present invention can be used not only as a preservation liquid and a rinsing liquid for contact lenses, but also as a diluting liquid for a contact lens cleaning agent. The contact lens cleaning agent used together with the solution of the present invention includes at least one of proteolytic enzymes, non-reducing polyhydric alcohols, alkali metal salts of boric acid, reducing agents and anionic surfactants. A detergent containing is desirable. More preferably, a detergent containing a protease as a main component is preferable, and at least one selected from the group consisting of a non-reducing polyhydric alcohol, an alkali metal salt of boric acid, a reducing agent and an anionic surfactant is preferred. Detergents containing seeds are desirable. Examples of preferred contact lens cleaning agents are described below.

The proteolytic enzyme that can be contained in the contact lens cleaning agent is preferably a microorganism-derived serine protease, and more preferably a Bacillus-derived serine protease. Further, a serine protease having further improved stability and functionality by genetic manipulation or modification of an enzyme by addition of a polymer may be used. Examples of the microorganisms belonging to the genus Bacillus include Bacillus subtilis, Bacillus lentus, Bacillus licheniformis, Bacillus thermoproteolyticus, Bacillus amyloliquefaciens, and Bacillus novo. Serine protease is the enzyme titer as measured by the Folin method and is 0.00001 to 10,000 PU / m in the preparation.
L, more preferably 0.001 to 50
It is blended in the range of 00PU / mL.

A non-reducing polyhydric alcohol can be added to the contact lens cleaning agent. Examples of the non-reducing polyhydric alcohol include glycerin, ethylene glycol, polyethylene glycol, propylene glycol, polypropylene glycol, sorbitol, mannitol, polyvinyl alcohol, and the like. The non-reducing polyhydric alcohol is present in the formulation in an amount of 0.1 to 80 (w /
v)%, preferably in the range of 1 to 55 (w / v)%. Salts such as sodium chloride and potassium chloride can also be blended as other tonicity agents.
The non-reducing polyhydric alcohols and salts mentioned above can be contained for the purpose of stabilizing the protease, stabilizing the reducing agent, and making the solution isotonic.

It is also possible to mix an alkali metal salt of boric acid into the contact lens cleaning agent. Examples of the alkali metal salts of boric acid include borax and potassium borate. These alkali metal salts of boric acid are incorporated in the preparation in an amount of 0.001 to 10.0 (w / v)%, preferably 0.01 to 5.0 (w / v)%. The above-mentioned alkali metal salts of boric acid can be contained as stabilizers for proteases.

Further, a reducing agent and / or an anionic surfactant can be added to the contact lens cleaning agent. Examples of the reducing agent include sulfite, hydrogen sulfite, disulfite, thiosulfate, ascorbic acid and alkali metal salts such as sodium salt, potassium salt and magnesium salt thereof, and N-acetyl-L-cysteine. One or more kinds are appropriately compounded from the group of. The reducing agent is contained in the preparation in an amount of 0.0001 to 50 (w /
v)%, preferably in the range of 0.001 to 10 (w / v)%. On the other hand, examples of anionic surfactants include α-olefin sulfonates, alkyl sulfonates, alkylbenzene sulfonates, carboxylated ether salts having a polyoxyethylene chain, alkyl phosphates, and polyoxyethylene chains. And alkyl ether phosphates / sulfates, alkyl sulfates, alkyl sulfate ethers, alkyl sarcosine salts, alkyloyl methyl taurine, alkyloyl benzalcosine, and the like. Among them, polyoxyethylene (3) alkyl ether triethanolamine sulfate is particularly preferred. The reducing agent and / or anionic surfactant mentioned above is
It can be included as an activator of proteolytic enzymes.

In addition to the above components, a cationic surfactant, an amphoteric surfactant, and a nonionic surfactant,
It may be blended for the purpose of a cleaning effect on fat stains. Examples of the cationic surfactant include tri (polyoxyethylene) stearyl ammonium chloride (5
E. FIG. O. ), Oleylbis (2-hydroxyethyl) methylammonium chloride, lanolin fatty acid aminopropylethyldimethylammonium ethosulfate and N-cocoyl-L-arginine ethyl ester-DL-
And pyrrolidone carboxylate. Examples of the amphoteric surfactant include sodium lauryl diaminoethyl glycine, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, and alkyldimethylamine oxide. On the other hand, examples of the nonionic surfactant include the same ones as those described above as the components of the liquid agent (storage / rinsing liquid).

The contact lens cleaning agent may further contain a metal chelating agent. The metal chelating agent has a function of removing a complex of a protein and an inorganic salt such as a calcium salt in the tear fluid attached to the lens surface, and also has a function as a stabilizer of the reducing agent. Examples of the metal chelating agent are the same as those listed as the components of the rinsing solution of the liquid agent of the present invention. The metal chelating agent is contained in the preparation in an amount of 0.001 to 10 (w / v)%, preferably 0.1 to 10 (w / v)%.
It is blended in the range of 01 to 1.0 (w / v)%.

The pH and osmotic pressure of the contact lens cleaning agent are adjusted to 100 to 10,000 mO so that the pH is in the range of 6.0 to 9.0 when mixed with the diluent.
sm. And more preferably 150 to 5,0
00mOsm. It is desirable to set it so that it is within the range. Such a contact lens cleaning agent is also preferably a liquid agent, and more preferably an aqueous solution. In the detergent, components other than the non-reducing polyhydric alcohol, the surfactant and the protease are dissolved in an appropriate amount of water, and the components are sufficiently dissolved by stirring for about 40 minutes. Thereafter, a non-reducing polyhydric alcohol is blended, and the mixture is further stirred for about 30 minutes. Then, after mixing the surfactant, the protease is mixed, and finally, the volume is adjusted with water, whereby it can be industrially advantageously prepared.

The liquid agent of the present invention can be used as a diluent for the above-mentioned contact lens cleaning agent, but may be used not only as a diluent but also for imparting a cleaning effect to the liquid agent itself of the present invention. In that case, since the liquid directly enters the eyes, it is necessary to make the most important design that there is no eye irritation. The compounding components can be appropriately compounded, as long as they are usually used as components for contact lenses, in addition to the components described above.

Next, a method for using the liquid agent of the present invention will be described. When used as a rinsing liquid for a non-hydrated contact lens, the worn contact lens is first washed, then the lens is rinsed with the liquid agent of the present invention, and then attached to the eye as it is. When the solution of the present invention is used as a diluting solution of a contact lens cleaning agent containing a protease, the solution is mixed so that the volume ratio of the contact lens cleaning agent to the solution of the present invention is 1: 1 to 100, and The mounted contact lens is immersed in the mixture for at least a minute. After the washing of the contact lens, the lens taken out of the mixed solution is rinsed with the liquid agent of the present invention, and is attached to the eye as it is. Furthermore, when the liquid agent of the present invention is used as a rinsing liquid for a contact lens that has been washed in another cleaning system, or when the contact lens that has been washed and rinsed in another cleaning system is directly attached to an eye. When a rugged feeling is felt, it is also possible to mount the lens after dropping a few drops of the liquid agent of the present invention on the inner surface of the contact lens, that is, to use it as a lens mounting liquid.

[0026]

EXAMPLES Hereinafter, the present invention will be described specifically with reference to Examples and Comparative Examples, but the present invention is not limited thereto.

Example 1 Each sample described in Table 1 was prepared according to the method described above. Sample 1, Sample 2 and Sample 3 are liquid preparations of the present invention, Comparative Liquid 1 and Comparative Liquid 2 are liquid preparations that do not satisfy the requirements of the present invention, and Comparative Liquid 3 is a non-hydrated contact lens of most commercial products. Since the rinsing was performed with tap water, it was used as a comparative liquid.

[0028]

[Table 1]

The preparation stability of the liquid preparation and the cleaning liquid of the present invention was examined for Sample 1, Sample 2, Sample 3 and the cleaning liquid shown in Table 1. The three-month changes under the conditions of 40 ° C. and a relative humidity of 75% were examined at four points before storage, one month storage, two months storage, and three months storage. The evaluation items were alkali metal salt, pH, osmotic pressure and kinematic viscosity for each sample, and the relative titer of proteolytic enzyme, anionic surfactant, reducing agent, pH and osmotic pressure for the washing solution. Examined.

The alkali metal salt was measured according to the sodium chloride quantification method described in the 13th revised edition of the Japanese Pharmacopoeia, and the end point was determined by potentiometric measurement using a silver electrode.
The titer of the protease was measured using the Folin method, and the relative titer was determined. The anionic surfactant was measured according to a methylene blue phase-separation reverse titration method, which is a JIS method described in Kodansha Publishing, “Analysis and Testing of Surfactants”. The reducing agent was measured according to the method for quantifying sulfite described in the official manual of the 7th edition of Food Additives, and the end point was determined by potentiometric measurement with an automatic titrator using a platinum electrode. Kinematic viscosity is based on the 13th revised Japanese Pharmacopoeia General Test Method "Viscosity Measurement Method"
It was measured according to the first method described.

Table 2 shows the results after the elapse of a predetermined time. The numerical values in the table are described as relative percentages (%) when the value before storage was set to 100. As a result, the sample and the washing solution of the present invention hardly changed before the start of storage and after 3 months of storage.
It was found that the formulation stability was excellent.

[0032]

[Table 2]

Example 2 With respect to the preservative effect of the liquid preparation of the present invention, according to the preservative efficacy test method described in the thirteenth revised Japanese Pharmacopoeia Reference Information, before the start of the preparation stability test, Samples 1 and 2 shown in Table 1 2 and Sample 3, and Comparative Solution 1 and Comparative Solution 2 were examined for antiseptic effect. In the test,
Three bacteria (Staphylococcus aureus: SA, Pseudomonas aeruginosa: PA, Escherichia coli: EC) and two fungi (Candida: CA, black mold:
AN) was used. In Table 3, the degree of reduction from the initial number of bacteria was shown in logarithmic representation using data on the 14th day from the start of the preservative efficacy test. Bacteria reduced the number of bacteria corresponding to three orders or more, and fungi did not increase more than the initial number of bacteria. Based on the criteria, Sample 1, Sample 2 and Sample 3 were all clear criteria for all species. Was cleared, and it was found that the solution could be sufficiently used as a preservative solution.

[0034]

[Table 3]

Example 3 The hydrophilicity of a contact lens treatment solution obtained by mixing the solution of the present invention with a contact lens cleaning agent was evaluated according to the following procedure. That is, in a lens case for a hard contact lens manufactured by Offtex, a cleaning solution: a dilution / rinsing solution (sample 1, sample 2, or sample 3) is mixed at a volume ratio of 1:40, and the hard solution is mixed in the mixed solution. After soaking the contact lens for 4 hours, the contact lens was lightly rinsed with a diluting / rinsing liquid and dried. In addition, since most other commercially available products were rinsed with tap water, those treated similarly and then rinsed with tap water (comparative solution 3) were used as comparative examples. The n number was 5 for each. The lens is placed so that the convex surface of the lens is on the top, and brilliant blue FCF (edible blue No. 1) is dissolved so as to be 0.02 (w / v)% in phosphate buffer specified by “ISO10344”. One drop of physiological saline was dropped on the hard contact lens, and the spread was visually observed. As a result, the saline solution was spread evenly on the hard contact lens for both the samples used as the dilution and rinsing solutions,
The comparative solution 3 remained in a granular state, indicating that the treatment solution for a contact lens of the present invention was excellent in hydrophilicity.

Example 4 The safety of the liquid preparation of the present invention was evaluated based on the “eye irritation test” defined by the Japan Contact Lens Association. That is, using a healthy white rabbit weighing 2 kg or more, 0.1 mL or more of the stock solution of Sample 1 was instilled at a time, and the eyes after the instillation were subjected to the Draize method (June 2, 1995 Ministry of Health and Welfare Pharmaceutical Affairs Bureau Evaluation was made according to Section 1) (Table 1). As a result, no problem was found, and it was found that there was no problem in safety. In addition, it was confirmed that the stock solution of this sample 1 did not feel "sticky feeling" and that there was no "unpleasant feeling" which was uncomfortable even when used when a non-hydrous contact lens was attached.

Example 5 The cleaning effect of the treatment solution for a contact lens of the present invention was confirmed by the cleaning effect on an oxygen-permeable hard contact lens that has been artificially stained (hereinafter referred to as an artificially soiled lens).

The artificially soiled lens is obtained by immersing an oxygen-permeable hard contact lens in an artificially soiled model liquid composed of egg white lysozyme, ovalbumin, fat and mucin, and heating the lens to 65 ° C. to fix the soil on the lens surface. Prepared. Next, in a lens case for a hard contact lens manufactured by Offtex, a cleaning solution shown in Table 1 and a diluting / rinsing solution (sample 1, sample 2 or sample 3) were used in a ratio of 1:
The mixture was mixed so as to have a volume ratio of 40, and the artificially soiled lens was immersed in each of the sample solutions for 4 hours. The artificially soiled lens after immersion was lightly rinsed with a diluting and rinsing liquid (sample 1, sample 2 or sample 3). After washing, the artificially soiled lens was immersed in an erythrosin solution for about 10 seconds, and rinsed lightly with tap water to remove excess erythrosin solution.
The dirt on the lens reacts with the red pigment of erythrosin, so the area is 5 levels (the one where the red pigment remains evenly on the lens is “1”, and the pigment is almost seen on the lens) Those without the condition were classified as “5”) and evaluated visually. Each sample solution was evaluated using five artificially soiled lenses, and the average value was determined. result,
The treatment solutions for contact lenses of the present invention exhibited values of 4.5 to 5 for all lenses. That is, it was found that the treatment solution for a contact lens of the present invention exhibited a good cleaning effect, and that the solution of the present invention could be sufficiently used as a diluent for the cleaning solution.

[0039]

EFFECT OF THE INVENTION The present invention provides a contact lens solution having a sufficient antiseptic effect even though it does not contain an antiseptic agent which may have a negative effect on the eyes, as a contact lens, particularly a non-water-containing contact lens rinsing solution. By using it, the contact lens after washing can be worn on the eyes in a clean state without touching microorganisms and viruses contained in tap water and well water. Further, even when clean tap water is not available during outdoor activities such as camping or when traveling abroad, the use of this agent has the advantage that the contact lens can be attached and detached at any time. Furthermore, by blending a thickener, especially hydroxyethylcellulose, it does not feel "sticky" and has a role as a cushioning agent between the contact lens and the cornea. "Rolling feeling" which is discomfort when wearing contact lenses is improved.

──────────────────────────────────────────────────の Continued on the front page (51) Int.Cl. ⁷ Identification FI FI Theme Court ゛ (Reference) // A61L 2/18 A61L 2/18 (72) Inventor Shigeru Nakamura 156-5 Kamimidai, Toyooka, Hyogo F-term in Offtex Laboratories, Inc. (reference) 2H006 DA08 DA09 4C058 AA09 BB07 JJ07 JJ08 JJ27 4H003 AB31 DA16 EA12 EA18 EA19 EB05 EB14 EB16 EB28 EB42 EC02 ED02 FA04 FA16 FA29 FA30

Claims (6)

[Claims] 1. A method comprising: (A) at least one selected from the group consisting of boric acid or a salt thereof and tris (hydroxymethyl) aminomethane; (B) a metal chelating agent; and (C) a thickener. And a pH of 6.0 to 8.5,
Osmotic pressure is 100-600 mOsm. And a kinematic viscosity of 0.9 to 10,000 mm ² / s. 2. The solution for contact lenses according to claim 1, wherein the solution is a preservative solution and / or a rinsing solution for contact lenses. 3. A liquid mixture obtained by mixing the liquid preparation for contact lenses according to claim 1 or 2 with the contact lens cleaning agent 1 so as to have a volume ratio of 1 to 100. Has a pH of 5.0 to 9.0 and an osmotic pressure of 100 to 10,000 mOsm. A treatment solution for contact lenses, characterized in that: 4. The contact lens cleaning agent contains at least one selected from the group consisting of proteolytic enzymes, non-reducing polyhydric alcohols, alkali metal salts of boric acid, reducing agents and anionic surfactants. The treatment solution for a contact lens according to claim 3, wherein: 5. The liquid preparation for a contact lens according to claim 1, wherein the target contact lens is a non-water-containing contact lens. 6. The treatment solution for a contact lens according to claim 3, wherein the target contact lens is a non-water-containing contact lens.