JP2002200061A - Component measurement apparatus - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a component measurement apparatus whose assembled chip can be quickly and securely disassembled. SOLUTION: This component measurement apparatus 1 has a casing 2 and a lid body 3 equipped on the tip end part of the casing 2. On the tip end part of the casing 2, an opening part 21 communicating with the inside is formed. In the inside of the casing 2, a chip holder 4 to detachably attach the chip 5 via the opening part 21 is mounted. When the lid body 3 is swung toward the closing direction to a normal open position to swing the lid body 3 from a condition the chip 5 is mounted in a mounting hole 41 of the chip holder 4 further to the opening direction, the chip 5 is pushed outside the casing 2 via the opening part 21 from the mounting hole 41 of the chip holder 4.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a component measuring device, and more particularly, to a blood test, in which a fingertip is punctured with a puncture needle to collect blood and the amount of a specific component such as glucose in the blood. The present invention relates to a component measuring device that measures

[0002]

2. Description of the Related Art In recent years, with the increase in the number of diabetic patients, autologous blood glucose measurement in which patients monitor daily fluctuations in blood glucose levels has been recommended. The measurement of the blood glucose level is performed by attaching a test paper that develops a color according to the amount of glucose in the blood, supplying the blood to the test paper, developing the color, and optically measuring the degree of the coloration ( The measurement is performed using a blood glucose measurement device that quantifies the blood glucose level by performing colorimetry. Prior to this measurement, as a method for the patient to collect his or her own blood, the patient punctures the skin at the fingertip using a puncture device equipped with a puncture needle or a scalpel, and then presses the area around the puncture part with a finger or the like to collect the blood. Squeezing is performed.

[0003] However, the fingertips are concentrated in capillaries and are suitable for collecting blood. On the other hand, since the nerves are concentrated and painful, the pain and burden on the patient are great. Because it involves fear,
Many patients are unable to continue their own blood glucose measurements.

In a conventional blood glucose measurement, a puncture operation and
Since the blood sampling operation and the measurement operation are performed separately, the operability is also poor.

As a device capable of solving such a problem, there is known a blood glucose measuring device in which a puncturing device and a measuring device are integrated and provided with a suction means for squeezing blood (Japanese Patent Application No. Hei 10 (1998)). 183794, Japanese Patent Application No. 10-33
0057).

In these blood glucose measuring devices, first, a chip is mounted on a chip holder of the device, a fingertip is pressed against the tip of the chip, and the opening of the tip is sealed so as to maintain airtightness.

Next, after the fingertip is punctured with a puncture needle protruding from the distal end opening, the suction means is operated (in a reduced pressure state) in this state, blood is sucked from the punctured site, and the blood is collected. Then, the blood glucose level of the collected blood is measured by the measuring device.

When the measurement is completed, the tip mounted on the tip holder of the blood glucose measuring device is removed (removed).

However, in the above-mentioned conventional component measuring device, when the chip is removed from the chip holder, the chip cannot be easily grasped with fingers, and it takes time and effort to remove the chip. There is a disadvantage that it takes a long time.

[0010]

SUMMARY OF THE INVENTION An object of the present invention is to provide a component measuring apparatus which allows a mounted chip to be easily, quickly and reliably removed.

[0011]

This and other objects are achieved by the present invention which is defined below as (1) to (18).

(1) A component measuring device which detachably mounts a chip provided with a means for collecting and holding a body fluid, and measures the amount and / or property of a predetermined component in the collected body fluid, wherein the chip is A casing having an opening to be inserted, and a lid provided to be displaceable with respect to the casing and covering the opening so as to be openable and closable, discharging the mounted chip with the operation of opening the lid. A component measuring device having an ejecting mechanism.

(2) The lid is provided so as to be displaceable with respect to the casing between a closed position, a first open position, and a second open position. When the lid is in the first open position, the chip can be mounted, and when the lid is displaced from the first open position to the second open position, the chip is ejected. The component measuring device according to the above (1), which is configured to be operated.

(3) A component measuring device for detachably mounting a chip provided with a means for collecting and holding a bodily fluid and measuring the amount and / or property of a predetermined component in the collected bodily fluid, wherein the chip is An opening to be inserted, an eject mechanism for ejecting the chip after being inserted, and a casing having a mounting portion for mounting the lid, and a lid having a portion to be mounted and covering the opening so as to be openable and closable. The lid is provided so as to be displaceable with respect to the casing by displaceably attaching the attached portion to the attachment portion, and the lid is interlocked with the displacement of the attached portion. An engaging portion that moves in association with the engaging portion is provided in the eject mechanism after engaging with the engaging portion; Is interlocked with the displacement of the attached part A component measuring device configured to eject the chip by moving the eject mechanism by moving the eject mechanism.

(4) A component measuring device for detachably mounting a chip provided with a means for collecting and holding a bodily fluid, and measuring an amount and / or property of a predetermined component in the collected bodily fluid, wherein the chip is An opening to be inserted, an eject mechanism for ejecting the chip after being inserted, and a casing having a mounting portion for mounting the lid, and a lid having a portion to be mounted and covering the opening so as to be openable and closable. The lid is provided so as to be displaceable with respect to the casing by attaching the attached portion to the attaching portion so as to be rotatable with respect to the mounting portion. An engaging portion is provided which rotates coaxially and coaxially with the engaging portion. The eject mechanism includes an engaged portion which coaxially rotates coaxially with the engaging portion after engaging with the engaging portion. Is provided, and the engaged portion is A component measuring device characterized in that the ejecting mechanism is operated and the chip is ejected by rotating the shaft coaxially in coordination with the shaft rotation of the mounting portion.

(5) The lid is provided so as to be displaceable between a closed position, a first open position, and a second open position with respect to the casing. In the first open position, the chip can be inserted into the opening, and when the lid is displaced from the first open position to the second open position, the chip is ejected. The component according to the above (3) or (4), wherein the lid is in the first open position until the engagement portion and the engaged portion engage with each other. measuring device.

(6) The component measuring apparatus according to any one of (1) to (5), wherein the means for collecting and holding the body fluid of the chip has a puncture needle for puncturing the epidermis.

(7) The component measuring device according to the above (6), further comprising a puncture means for operating the puncture needle so as to puncture the epidermis.

(8) Along with a storage space for the puncture needle,
The component measuring device according to the above (6) or (7), further comprising a decompression means for decompressing a puncture site of the epidermis by the puncture needle.

(9) A component measuring device for detachably mounting a tip provided with a puncture needle, wherein the opening is formed at the tip and communicates with the inside, and a puncture is formed near the opening. A casing having a contact portion to which the outer skin is applied, a lid provided at the tip of the casing, and swingable in a direction to open and close the opening, and provided inside the casing, near the tip, A tip holder having a mounting hole in which the tip is removably mounted via the opening, puncturing means for operating the puncture needle to puncture the epidermis applied to the abutment, and a puncturing site of the epidermis Measuring means for measuring an amount and / or property of a predetermined component in the collected body fluid from the body fluid, and swinging the lid in the opening direction to a normally open position to place the chip in the mounting hole of the chip holder. The tip is ejected from the mounting hole of the chip holder through the opening when the lid is further swung in the opening direction from the state where the chip is mounted. Component measuring device.

(10) A slider located in the casing and movable in a direction approaching and moving away from the tip of the casing, and an extruding portion provided on the slider and capable of pushing out the chip to the outside of the casing. The component according to (9), further comprising: interlocking means for moving the slider in the approach direction in conjunction with the swing of the lid further in the opening direction beyond the normal opening position. measuring device.

(11) The interlocking means is provided at one end directly or indirectly connected to the slider, and the other end is provided at an end of the casing with an operating link projecting outward from the end of the casing. The other end of the operation link includes a locking portion that can be engaged and disengaged, and a hook portion that is provided on the lid and that can hook the other end of the operation link, and further moves the lid beyond the normal open position. When swinging in the opening direction, the hook portion is hooked on the other end of the operating link, the other end of the operating link is detached from the locking portion, and the operating link moves in the approaching direction. The component measuring device according to the above (10), configured as described above.

(12) The interlocking means further includes a swing link having one end connected to the inside of the casing and capable of swinging in a direction approaching or moving away from the tip of the casing. The other end is connected to the slider so as to be movable in the longitudinal direction of the swing link, and one end of the operating link is connected to the swing link.
The component measuring device according to 1).

(13) The component measuring device according to any one of (10) to (12), further including an urging means for urging the slider in a direction away from the tip of the casing.

(14) The component measuring apparatus according to any one of (9) to (13), further comprising a decompression means for decompressing a puncture site of the epidermis by the puncture needle together with a storage space for the puncture needle.

(15) The puncturing means is provided in the tip holder, and the decompression means puts the storage space in the tip holder into a decompressed state.
The component measuring device according to 1.

(16) The above-mentioned chips (1) to (15), wherein the chip has an abutting portion which abuts on the epidermis, and is used so as to close an opening formed inside the abutting portion with the epidermis.
The component measuring device according to any one of the above.

(17) The component measuring device according to any one of (1) to (16), wherein the chip has a test paper and a passage for supplying a body fluid to the test paper.

(18) The component measuring device according to (17), wherein the test paper is a test paper for measuring blood glucose.

[0030]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, a component measuring apparatus according to the present invention will be described in detail based on a preferred embodiment shown in the accompanying drawings.

The component measuring device of the present invention is a device that collects a body fluid (hereinafter, a representative example is blood in the present embodiment) through the epidermis (skin) and measures a predetermined component of the body fluid. .

The puncture site of the epidermis involved in the collection of the body fluid is preferably a finger, but may be a palm, a back of a hand, a side of a hand, an arm, a thigh, an earlobe, or the like.

In the following embodiment, a component measuring apparatus in which a fingertip (finger) is punctured will be described as a representative.

FIG. 1 is a partial side sectional view showing an embodiment of a component measuring apparatus according to the present invention, showing a state in which a lid is closed.
Is a partial side sectional view showing a state where the lid of the component measuring device shown in FIG. 1 is opened to a normal open position, and FIG. 3 is a state where the lid of the component measuring device shown in FIG. FIG. 4 is a partial side sectional view showing a state where the cover of the component measuring device shown in FIG. 1 is further opened beyond the normal open position, and FIG. 5 is a sectional view of the component measuring device shown in FIG. FIG. 6 is a partial front sectional view showing a state in which the lid is further opened beyond the normal open position. FIG. 6 is a longitudinal sectional view showing a configuration example of a chip used in the present invention. FIG. 7 is a component measuring device shown in FIG. FIG. 8 is a longitudinal sectional view showing a state before a chip is mounted on the chip holder of FIG.
Is a longitudinal sectional view showing a state in which a chip is mounted on the chip holder of the component measuring device shown in FIG. 1, and FIGS. 9 to 12 are longitudinal sectional views each showing a configuration example of a main part in the component measuring device shown in FIG. FIGS. 13 and 13 are block diagrams showing the circuit configuration of the component measuring device shown in FIG. 1, and FIG. 14 is a flowchart showing the operation (including a part of the operation of the operator) of the component measuring device shown in FIG. is there. 1 to 12, the upper side is described as “distal end” or “approaching direction”, and the lower side is described as “proximal end” or “separation direction”.

As shown in FIGS. 1 to 5, the component measuring device 1
Has a casing (body) 2 as a base,
An opening 21 that communicates with the inside of the casing 2 and into which a chip 5 to be described later is inserted is formed at the tip of the casing 2.
Further, in the vicinity of the opening 21 at the tip of the casing 2, a contact portion 22 to which a fingertip (finger) 200 to be punctured is applied.
Is provided.

A pair of support brackets (mounting portions) 23 are provided at the distal end of the casing 2, and the lid 3 has an opening at a mounting portion 30 through a swing shaft 31 on the pair of support brackets 23. It is provided (attached) so as to be able to swing (rotate) in the direction in which it opens and closes (opening direction, closing direction), i.

The lid 3 is provided on the casing 2 with respect to FIG.
2 (in a state where the opening 21 is covered) and FIG.
And the first open position shown in FIG. 3 and FIGS.
In a second open position shown in FIG.

A fixing recess 24 is formed in the center near the front end of the casing 2, and a hook that engages with the fixing recess 24 when the casing 2 closes the opening 21 is formed in the center of one end of the lid 3. 32 are provided.

As shown in FIGS. 7 and 8, a chip holder 4 is installed inside the casing 2, and a mounting hole 41 is formed near the tip of the chip holder 4. Further, a storage space 42 communicating with the mounting hole 41 is formed inside the chip holder 4. In addition, a ventilation pipe 43 is provided on the side of the tip holder 4, and the ventilation pipe 43 is
It communicates with the storage space 42.

A chip 5 having means for collecting and holding blood (body fluid) is removably mounted in the mounting hole 41 of the chip holder 4 through an opening 21. That is, the component measuring device 1 is used with the chip 5 mounted thereon.

As shown in FIG. 6, the chip 5 has a first chip body 51 which can be attached to and detached from the mounting hole 41 of the chip holder 4.

The first chip main body 51 has a substantially cylindrical shape and has a middle cavity 511. This first chip body 5
A flange portion 512 is formed at the front end of 1.

Further, a ring-shaped contact portion 513 which can press the fingertip 200 is formed at the tip of the first chip main body 51. When the fingertip 200 is pressed against the contact portion 513, the puncture site 21
It has a shape suitable for exerting the effect of stimulating the vicinity of 0 and relieving pain at the time of puncture. In addition, the shape of the contact portion 513 minimizes the inflow of air from between the contact portion 513 and the surface of the fingertip 200 when the inner cavity 511 of the first chip main body 51 is in a reduced pressure state. It is suitable for In addition, at the tip of the first chip body 51,
The contact portion 513 may not be formed, and the distal end surface of the first chip body 51 may be configured as a flat surface. A second chip body 52 is fixed to the inner peripheral portion of the first chip body 51.

The second chip body 52 has a bottomed cylindrical shape,
It has a middle cavity 521 and a bottom 522. A hole 523 having a circular cross section is formed at the center of the bottom portion 522, and the first chip body 51 is formed through the hole 523.
Of the second chip body 52 communicates with the inner cavity 511 of the second chip body 52.

The lumen 521 of the second chip body 52 has
A substantially cylindrical hub 53 is slidably provided.

At the distal end of the hub 53, the proximal end of a puncture needle 54 for puncturing the epidermis of the fingertip 200 is fixed.

The puncture needle 54 is formed of a hollow member or a solid member made of a metal material such as stainless steel, aluminum, an aluminum alloy, titanium, and a titanium alloy. Needle point) is formed.

Here, when the fingertip (finger) 200 is punctured,
The puncture needle 54 passes through the hole 523. The inner diameter of the hole 523 is set smaller than the outer diameter of the tip of the hub 53. For this reason, the puncture needle 54 moves in a direction (approaching direction) approaching the tip of the casing 2, and the tip of the hub 53 and the bottom 522 of the second tip body 52.
When the edge of the hole 523 abuts, the puncture needle 54 is prevented from further moving in the approach direction.
Therefore, when the fingertip 200 is punctured, the projection length of the puncture needle 54 from the tip of the first tip main body 51 is kept constant. Therefore, it is possible to more reliably prevent the cutting edge of the puncture needle 54 from puncturing the fingertip 200 deeper than necessary.

A mechanism for adjusting the moving distance of the plunger 61, which will be described later, may be provided to adjust the depth of the puncture of the fingertip 200 by the cutting edge of the puncture needle 54.

On the outer periphery of the first chip body 51, a concave portion 51 is provided.
The test paper fixing member 56 on which the circular test paper 55 is set is mounted in the concave portion 514. The test paper 55 has a reagent supported on a carrier capable of absorbing and developing blood.

Here, as the carrier, for example, a nonwoven fabric,
Sheet-like porous bodies such as woven fabrics and stretched sheets are exemplified. The porous body preferably has hydrophilicity.

The reagent carried on the carrier is appropriately determined depending on the component to be measured in the blood (sample). For example, in the case of blood glucose measurement, glucose oxidase (GOD)
And peroxidase (POD), for example, 4-aminoantipyrine, N-ethyl N- (2-hydroxy-3-
A color-forming agent (color-forming reagent) such as sulfopropyl) -m-toluidine; and other components that react with blood components such as ascorbate oxidase, alcohol oxidase, and cholesterol oxidase, depending on the components to be measured. The same coloring agent (coloring reagent) as described above can be used. Further, a buffer such as a phosphate buffer may be included. In addition, about the kind and the component of the reagent,
It goes without saying that the present invention is not limited to these.

An entrance hole 515 through which blood (specimen) obtained by puncturing can enter is formed in the outer peripheral portion of the first chip body 51, and the inside edge of the entrance hole 515 is provided with the first chip body 51. An introduction guide 516 is formed to receive the blood that has entered the lumen 511. A guide passage 561 through which blood flows is formed in the test paper fixing member 56, and the entrance end of the guide passage 561 is communicated with the entrance hole 515, and the guide passage 5
The outlet end of 61 is located at the center of the test paper 55. Therefore, the blood received by the introduction guide 516 is efficiently guided from the entrance hole 515 to the guide passage 561, reaches the outlet end of the guide passage 561 by capillary action, and is supplied to the center of the test paper 55. It expands radially.

As shown in FIGS. 7 and 8, the storage space 42 and the like of the chip holder 4 (mainly the storage space 42)
Puncturing means 6 for operating puncture needle 54 so as to puncture the epidermis of fingertip 200 applied to application section 22 is provided. Details of the configuration of the puncturing means 6 are as follows.

That is, the storage space 42 of the chip holder 4
The plunger 61 is provided so as to be movable in a direction (approach direction, separation direction) in which the plunger 61 approaches and separates from the tip of the tip holder 4. At the distal end of the plunger 61, there is provided a joint portion 611 into which the proximal end of the hub 53 is fitted. At the proximal end of the plunger 61, an elastically deformable elastic piece 613 having a locking projection 612 is provided. Is provided.

On the side of the tip holder 4, a locking projection 61 is provided.
A long hole 44 is formed in which the second hole 2 can be locked, and the long hole 44 communicates with the storage space 42. Slot 4 in casing 2
In the vicinity of the lock release member 6, the locking protrusion 612 is pressed to the left in FIG. 8 to release the locked state of the locking protrusion 612.
2 are provided.

Here, in a state before the chip 5 is mounted on the chip holder 4 (see FIG. 7), the locking projection 612 is urged rightward in FIG. 4 is in contact with the inner surface (the surface defining the storage space 42). On the other hand, when the chip 5 is mounted on the chip holder 4 (see FIG. 8), the locking projection 612 is
And restricts the movement of the plunger 61 in the approaching direction.

A sealing member 6 is provided on the side of the tip holder 4.
3 is provided so as to cover the elongated hole 44, and the airtightness of the storage space 42 is maintained by the seal member 63. The seal member 63 is made of an elastic material. Examples of such an elastic material include natural rubber, isoprene rubber, butadiene rubber, styrene-butadiene rubber, nitrile rubber, chloroprene rubber, butyl rubber, acrylic rubber, and ethylene-
Various rubber materials such as propylene rubber, hydrin rubber, urethane rubber, silicone rubber, and fluorine rubber, and various types such as styrene, polyolefin, polyvinyl chloride, polyurethane, polyester, polyamide, polybutadiene, and fluorine rubber Thermoplastic elastomers.

A first coil spring 64 for urging the plunger 61 in the above-mentioned separating direction is provided on the distal end side of the plunger 61 in the storage space 42, and the first coil spring 64 is provided on the base end side of the plunger 61 in the storage space 42. A second coil spring 65 that urges the jar 61 in the approach direction is provided.

As shown in FIG. 9, inside the casing 2
The decompression means 7 for decompressing the storage space 42 and the lumens 511 and 521 is provided. The details of the configuration of the pressure reducing means 7 are as follows.

That is, one end of a suction tube 71 is connected to the ventilation tube 43 of the tip holder 4, and the storage space 42 and the lumens 511, 5 are connected to the other end of the suction tube 71.
21 is connected to a pump 72 for sucking air. One end of the branch tube 73 is connected to the middle of the suction tube 71, and the other end of the branch tube 73 is open to the outside (atmosphere). An electromagnetic valve 74 that opens and closes (opens / closes) the flow path is provided in the middle of the branch tube 73.

Here, the suction tube 71 and the branch tube 73 have flexibility, and for example, polyolefin such as polyvinyl chloride, polyethylene, polypropylene, ethylene-vinyl acetate copolymer (EVA), polyamide, etc. , Polyester, silicone rubber, and polyurethane.

The pump 72 can reduce the pressure in the storage space 42 and the lumens 511 and 521 to such an extent that blood can be sucked from the puncture site 210 of the fingertip 200 (for example, about 100 to 400 mmHg). What is necessary is just such.

As shown in FIGS. 6 and 13, measuring means 8 for measuring blood collected from puncture site 210 of fingertip 200 is provided in casing 2, and measuring means 8 is provided in casing 2. And a control system 9 for controlling the driving of the pump 72 and the like. Details of the configuration of the measuring means 8 and the control system 9 are as follows.

That is, a measuring block 81 is provided near the tip of the tip holder 4, and a light emitting element (light emitting diode) 82 for emitting light toward the test paper 55 and a test paper Light receiving elements (photodiodes) 83 for receiving the light reflected from 55 are provided, respectively.

The light emitting element 82 is electrically connected to the control means (MPU) 91 of the control system 9 and the light receiving element 83
Is electrically connected to a control means 91 via an amplifier 92 and an A / D converter 93. Note that the light emitting element 82
Is preferably pulsed light that emits intermittently at predetermined time intervals.

With the chip 5 mounted in the mounting hole 41 of the chip holder 4, the light emitted from the light emitting element 82 is irradiated on the test paper 55, and the reflected light is received by the light receiving element 83 and photoelectrically converted. Is done. An analog signal corresponding to the amount of received light is output from the light receiving element 83 and the analog signal is output to the amplifier 9.
After being amplified as desired in step 2, the signal is converted into a digital signal by the A / D converter 93 and input to the control means 91. Then, based on the input signal,
It is determined whether or not blood has been collected, that is, whether or not blood has been spread on the test paper 55 of the chip. Further, the control means 91 performs predetermined arithmetic processing based on the input signal (and performs correction calculation if necessary) to obtain the amount of glucose in blood (blood glucose level).

A display section 94 is electrically connected to the control means 91 so that the display section 94 can be observed from outside the casing 2 through a display window (not shown).
The display unit 94 is, for example, a liquid crystal display (LCD).
In addition to the blood glucose level, for example, power on / off, power supply voltage (remaining battery level), measurement date and time, error display, operation guidance, and the like can be displayed.

Further, as shown in FIG.
Inside, a battery 95 is detachably installed as a power source. The battery 95 is electrically connected to the pump 72, the solenoid valve 74, the control means 91, the display unit 94, and the like, and supplies electric power necessary for the operation thereof.

The component measuring device 1 has an eject mechanism (discharge mechanism) for discharging the mounted chip 5 in accordance with the operation of opening the lid 3.

When the lid 3 is in the first posture (the posture shown in FIGS. 2 and 3), the chip 5 can be mounted on the chip holder 4 and the lid 3 is moved from the first posture. The tip 5 is configured to be ejected when displaced to the second posture (the posture shown in FIGS. 4 and 5).

That is, the eject mechanism swings the lid 3 in the opening direction to the normal opening position (the position shown in FIGS. 2 and 3) to move the tip 5 to the mounting hole 41 of the tip holder 4.
When the lid 3 is further swung in the opening direction as shown in FIGS. 4 and 5 from the state in which the casing 5 is mounted on the It is configured to be pushed outward (discharged). The details of the configuration are as follows.

As shown in FIGS. 1 to 5, the tip holder 4
A pair of guide bars 10 extending in a direction approaching and separating from the tip of the chip holder 4 (approaching direction, separating direction) is formed on the supporting flange 45 at the outer peripheral portion of the mounting member 11. Is provided via A slider 12 is mounted on the pair of guide bars 10 with the tip holder 4.
Is provided so as to be movable in a direction approaching or moving away from the tip of the camera.

The slider 12 includes a pair of cylindrical sliding parts 121 slidably provided in the pair of guide bars 10 in the direction of approaching and moving away from each other, and a connecting part 122 connecting the pair of sliding parts 121 to each other. A pair of arm portions 123 provided integrally at both ends of the connecting portion 122, a bottomed tubular spring support portion 124 provided integrally at a center portion of the connecting portion 122, and a side surface of the spring support portion 124. And the engagement convex portion 125 provided in the first position.

Each of the arms 123 of the slider 12 comes into contact with the flange 512 of the chip 5, and the eject pin (extrusion part) 13 which can push the chip 5 out of the casing 2 (upward in the figure). Is provided via the mounting member 14.

Each eject pin 13 has a corresponding guide hole 51 formed at the tip end of the tip holder 4.
7 is movably supported (inserted). That is, each eject pin 13 is provided with a corresponding guide hole 5.
The movement direction of the chip holder 4 is regulated by the reference numeral 17 so that the chip holder 4 can move in the longitudinal direction (vertical direction in the figure).

Further, inside the casing 2, the support piece 2 is provided.
5 is provided, one end of a swing link 15 swingable in the direction of approaching and separating from the support piece 25 is connected via a connection pin 151, and the other end of the swing link 15 is connected to a swing link. 15 are formed with notches 152 extending in the longitudinal direction. The notch 152 of the swing link 15 is connected to the engaging projection 125 of the slider 12 so as to be movable in the longitudinal direction of the swing link 15.

Instead of forming the notch 152 at the other end of the swing link 15, an elongated hole extending in the longitudinal direction of the swing link 15 may be formed.

Instead of forming the engaging projection 125 and the notch 152, the slider 12 is formed with an elongated hole extending in a direction perpendicular to the approaching / separating direction, and a swing link. At the other end of 15, an engaging convex portion movably inserted into the long hole may be formed.

One end of a U-shaped operating link (engaged portion) 16 is connected to the swing link 15, and the other end (first and second other ends) of the operating link 16 is connected to a casing. 2 protrudes through the through hole 26 outside.

Note that one end of the operating link 16 may be directly connected to, for example, the slider 12 instead of the swing link 15.

An operating link 16 is provided at the end of the casing 2.
A pair of locking portions 27 (only one locking portion is shown in the drawing) capable of locking the first other end and the second other end of the operation link 16 are provided on the lid 3. The other end and the second
A pair of hooking portions (engaging portions) 33 capable of hooking (engaging) the other ends are provided.

When the lid 3 is further swung in the opening direction beyond the normal opening position, the pair of hooks 33
Are hooked (engaged) with the first and second other ends of the operating link 16, and the first and second other ends of the operating link 16 are separated from the pair of locking portions 27, respectively. Thus, the operation link 16 is configured to move in the approach direction.

Here, when the lid 3 is further swung in the opening direction beyond the normal opening position, the slider 12
Moving means in the approach direction is a swing link 1
5, the operating link 16, the locking part 27, and the hook part 3.
And 3.

The spring support portion 124 of the slider 12 is provided with a coil spring (biasing means) 17 for biasing the slider 12 in the separating direction.
Spring retainer 18 for holding coil spring 17 from above in the figure
Are formed. When the slider 12 is urged in the separating direction by the coil spring 17, the swing link 15 and the operating link 16 are urged in the separating direction.

Next, the operation of the component measuring apparatus will be described with reference to FIG.
This will be described with reference to flowcharts shown in FIGS.

[1] First, from the state in which the lid 3 is closed as shown in FIG. 1, as shown in FIGS.
Is swung in the opening direction to the normal opening position to open the opening 21 of the casing 2. At this time, the attached portion 30 of the lid 3 pivots in the opening direction with respect to the support portion bracket 23, and the (in conjunction with) the pair of hooking portions 33 also pivots coaxially with the support portion bracket 23. Are hooked (engaged) with the first end and the second end of the operating link 16, respectively.

Then, as shown in FIGS. 7 and 8, the chip 5 is inserted through the opening 21 and is mounted in the mounting hole 41 of the chip holder 4 through the opening 21 so that the base of the hub 53 is connected to the plunger. It is fitted (joined) to the joining portion 611 of Step 61 (Step S101 in FIG. 14).

At this time, the plunger 61 is
Is pressed, and the plunger 61 is moved to the second coil spring 6.
5 moves in a direction (separation direction) away from the tip of the tip 5 against the urging force of the tip 5, and the locking projection 612 of the plunger 61 is locked in the elongated hole 44 by the elastic force of the elastic piece 613 ( See FIG. 8). Thereby, even if the pressing by the chip 5 is released, the movement of the plunger 61 in the direction approaching the casing 2 (approaching direction) is restricted.

Thus, preparation for puncturing by puncturing means 6 and preparation for blood (sample) collection are completed.

[2] Next, a power switch (not shown)
Is turned on. Thereby, each part of the component measuring device 1 is activated and becomes in a measurable state. Note that the solenoid valve 74 is closed.

Then, the fingertip (finger) 200 is pressed against the contact portion 22. Thus, the fingertip 200 is pressed against the contact portion 513 of the chip 5. At this time, the tip opening (opening) 518 is closed with the fingertip 200 so as to minimize air leakage (see FIG. 9).

[3] After the operation of [2], an operation button (not shown) is pressed to puncture the surface of the fingertip 200 (step S102 in FIG. 14).

That is, when the operation button is pressed, the lock release member 62 linked to the operation button moves to the left in FIG. 5 to release the locked state of the locking projection 612 of the plunger 61. And plunger 61 is second
Due to the urging force (elastic force) of the coil spring 65, the casing 2
The puncture needle 54 protrudes from the tip of the first tip main body 51 to puncture the surface of the fingertip 200, and bleeding occurs from the puncture site 210 of the fingertip 200 (the approach direction). (See FIG. 10).

[4] After the puncture needle 54 punctures the fingertip 200, the first coil spring 64 pushes the plunger 61 back in the above-mentioned separating direction. Then, the plunger 61 stops at a position where the elastic force (biasing force) of the first coil spring 64 and the elastic force (biasing force) of the second coil spring 65 balance through the damping movement (see FIG. 11). At this time, the cutting edge of the puncture needle 54 is located inside the tip bodies 51 and 52. As described above, the cutting edge of the puncture needle 54 does not protrude from the tip of the first tip main body 51 except at the time of puncture, so that it does not accidentally injure the skin or the like and can prevent infection. High safety.

[5] The operation switch (not shown) of the pump 72 is turned on by pressing the operation button, and the control means 91 starts the operation of the pump 72 (step S103 in FIG. 14).

That is, the pump 72 operates almost at the same time as the operation [4], and the storage space 42 and the lumen 51 are operated.
1, 521, the suction of the air in the inner cavity 511,
The inside of 521 is in a reduced pressure state.

At this time, the puncture site 210 of the fingertip 200 with the puncture needle 545 is also in a decompressed state.
From 10 blood is drawn. The blood protruding in a granular manner on the puncture site 210 is supplied to the lumen 511 of the first chip body 51.
Is sucked.

As described above, in the component measuring device 1, the puncturing operation and the depressurizing operation are performed almost simultaneously by pressing the operation button once, so that the operability is extremely good.

[6] The blood sucked into the inner cavity 511 of the first chip main body 51 by the operation of the above [5] comes into contact with the introduction guide 516 and enters the entrance hole 515 and the guide passage 5.
It is supplied to the center of the test paper 55 via 61 and is developed radially (see FIG. 6). Then, the glucose in the blood (the component to be measured) reacts with the reagent carried on the test paper 55, and the test paper 5 is colored according to the amount of glucose.

On the other hand, after executing the step S103 shown in FIG. 14, the control means 91 drives the measuring means 8 and monitors the coloration of the test paper 55 via the measuring means 8 (monitor).
Then, it is determined whether or not blood has been collected (step S104 in FIG. 14).

In this step S104, when the voltage level of the signal input from the light receiving element 83 of the measuring means 8 exceeds a preset threshold value, it is determined that blood has been collected, and If the voltage level is below the threshold, it is determined that blood has not been collected.

The threshold value is sufficiently higher than the voltage level of the signal before the test paper 55 is colored, and
The value is set to a value sufficiently smaller than the voltage level of the signal when the color is displayed.

If it is determined in step S104 that blood has not been collected, it is determined whether or not the time is up (step S105 in FIG. 14). And
If it is determined that the time is not up, step S
Returning to step 104, the steps from step S104 are executed again,
If it is determined that the time is up, an error process is performed (step S106 in FIG. 14).

In step S106, the operation of the pump 72 is stopped, the solenoid valve 74 is opened to release the reduced pressure state, and a display indicating an error (error display) is displayed on the display unit 94. I do. Operator (user)
Can be grasped from the error display as an error (there is a problem).

In step S104,
If it is determined that blood has been collected, the drive of the pump 72 is stopped (step S107 in FIG. 14).

Next, the solenoid valve 74 is opened to release the reduced pressure state (step S108 in FIG. 14).

Thus, the storage space 42 and the lumen 5
Outside air (atmosphere) flows into the storage space 4 through the branch tube 73, the suction tube 71, and the ventilation tube 43.
2 and the lumens 511, 521 return to atmospheric pressure (see FIG. 12).

When the sense of suction around the puncture site 210 of the fingertip 200 disappears and it is confirmed that the pressure has returned to the atmospheric pressure, the fingertip 200 is released from the contact portion 513 of the chip 5.

[7] After executing the step S108 shown in FIG. 14, the control means 91 measures the degree of coloration of the test paper 55 by the measuring means 8, performs arithmetic processing based on the obtained data, and corrects the temperature. The blood sugar level is quantified by performing calculations, hematocrit value correction calculations, and the like (step S109 in FIG. 14).

Here, since the decompressed state of the storage space 42 is released, components in the atmosphere (for example, components in the air necessary for the reaction between glucose in blood (component to be measured) and the reagent carried on the test paper 55) , Oxygen, carbon dioxide, water vapor, etc.) are sufficiently supplied to the test paper 55, and the blood sugar level can be accurately measured.

Next, the calculated blood sugar level is displayed on the display unit 94.
(Step S110 in FIG. 14). Thereby, the blood sugar level can be grasped.

After the decompression state is released, the solenoid valve 26 is closed again to prepare for the next measurement.

[8] Next, in order to remove the chip 5, the lid 3 is moved from the normal open position shown in FIGS.
And further swinging in the opening direction as shown in FIG.

At this time, the mounted portion 30 of the lid 3 pivots in the opening direction with respect to the support bracket 23, and the (in conjunction with) the pair of hooks 33 also pivots coaxially. . Since the pair of hooks 33 are hooked (engaged) with the first and second other ends of the operating link 16, respectively, the first and second other ends of the operating link 16 are paired. , Respectively, and coaxially rotates with the pair of hooking portions 33 and the attached portion 30, and the operating link 16 moves in the approaching direction.

As a result, the swing link 15 swings in the approach direction, and the slider 12 moves in the approach direction against the urging force of the coil spring 17. The pair of eject pins 13 move integrally with the slider 12 in the approach direction, and the tips of the eject pins 13 abut against the flange portions 512 of the chip 5, respectively.
3, the tip 5 is pushed out (discharged) from the mounting hole 41 of the tip holder 4 to the outside of the casing 2 via the opening 21. That is, the tip 5 moves to the tip end side, and the tip end side of the tip 5 projects outside the casing 2 from the opening 22.

Thereafter, the tip 5 is detached from the mounting hole 41 of the tip holder 4 by grasping the tip of the tip 5 and pulling the tip 5 outward of the casing 2 (step S111 in FIG. 14). Thus, the chip 5 is removed.

[9] After the operation of [8] is completed, the lid 3 is swung in the closing direction to close the opening 21 of the casing 2 as shown in FIG.

As a result, the first and second other ends of the operating link 16 and the pair of hooks 33 are released from the hooked state, and the urging force of the coil spring 17 causes the slider 12 and the pair of eject pins 13 to move. The swing link 15 moves in the separating direction, whereby the swing link 15 swings in the separating direction.

By the swing of the swing link 15 in the separating direction, the operating link 16 moves in the separating direction.
The first and second other ends of the operation link 16 are locked by the pair of locking portions 27 again.

In this way, the component measuring device 1 (the lid 3, the slider 12, the eject pin 13, the swing link 1
5, the operation link 16, the coil spring 17, etc.) return to the original state shown in FIG.

As described above, this component measuring device 1
According to the above, the tip 5 is attached to the mounting hole 41 of the tip holder 4 only by swinging the lid 3 further from the normal opening position to the opening direction.
Can be pushed (discharged) to the outside of the casing 2 through the opening 21, so that the chip 5 can be gripped by a simple operation, the detachment operation of the chip 5 becomes easy, and the component measuring device 1. The convenience of handling is improved.

Further, since the test paper 55 is provided on the chip 5, puncturing, blood collection, development on the test paper 55, and measurement (quantification of components) can be continuously performed.
Blood glucose measurement (component measurement) can be performed easily and in a short time.

Further, the preparation operation at the time of use is easy, and therefore, it is advantageous even when it is used regularly or repeatedly.

In addition, accidents such as accidental puncturing of the living body surface after puncturing once are prevented, and the safety is high. Moreover, since the puncture needle 54 is not directly visible, fear of puncturing is reduced.

The component measuring device 1 has a simple structure, is small in size and light in weight, is inexpensive, and is suitable for mass production.

Although the component measuring apparatus of the present invention has been described based on the illustrated embodiment, the present invention is not limited to this. For example, the configuration of each part can exhibit the same function. Any configuration can be used.

In the above embodiment, the lid 3 assumes the first open position when the hook portion (engaging portion) 33 and the operating link (engaged portion) 16 are engaged. In the invention,
The lid 3 may be configured to be in the first open position before the hook portion (engaging portion) 33 and the operating link (engaged portion) 16 are engaged.

In the above-described embodiment, the lid 3 is provided so as to be able to swing (rotate) with respect to the casing 2. It may be provided so as to be slidable (movable in a predetermined direction). That is, in the present invention, the lid 3 may be provided so as to be displaceable with respect to the casing 2.

[0130] In the above embodiment, blood was used as a representative example of the body fluid to be collected. However, in the present invention, the body fluid to be collected is not limited to this. For example, sweat, lymph, cerebrospinal fluid, etc. Good.

In the above embodiment, glucose (blood sugar level) was described as a representative component to be measured. However, in the present invention, the component to be measured is not limited to this. For example, protein, cholesterol, Inorganic ions such as uric acid, creatinine, alcohol, and sodium may be used.

In the above embodiment, the measuring means measures the amount of the predetermined component, but in the present invention, the measuring means may measure the property of the predetermined component. It may measure the amount and properties of a predetermined component.

In the above-described embodiment, the blood sampling detecting means for detecting the blood sampling and the measuring means for measuring the amount of the predetermined component in the blood (in this embodiment, this means is referred to as "measuring means"). However, in the present invention, the blood sampling detecting means and the measuring means may be separately provided.

In the above-described embodiment, a means for optically detecting blood collection is used as the blood collection detecting means. However, the present invention is not limited to this.
Means for electrically detecting may be used.

Further, the component measuring device of the present invention optically measures (colorimetrically measures) the color intensity of the test paper colored by the reaction between the components in blood and the reagent as described above, and converts the measured value into a measured value. The present invention is not limited to the conversion and display. For example, a potential change generated according to the amount of the component in the sample may be electrically measured, converted to a measured value, and displayed.

In the above-described embodiment, the reduced pressure state is released before the measurement. However, in the present invention, the reduced pressure state may be relaxed before the measurement.

[0137]

As described above, according to the present invention, a mounted chip can be easily (quickly and easily) removed (removed).

In particular, the chip can be pushed out (discharged) from the mounting hole of the chip holder to the outside of the casing through the opening simply by swinging the lid further from the normal opening position to the opening direction. The chip can be gripped by the operation. For this reason, the chip removal operation (removal operation) is facilitated, and the handling of the component measuring device is improved.

[Brief description of the drawings]

FIG. 1 is a partial side sectional view showing an embodiment of a component measuring device of the present invention, showing a state in which a lid is closed.

FIG. 2 is a partial side sectional view showing a state where a lid of the component measuring device shown in FIG. 1 is opened to a normal open position.

FIG. 3 is a partial front sectional view showing a state where a lid of the component measuring device shown in FIG. 1 is opened to a normal open position.

FIG. 4 is a partial side sectional view showing a state where the lid of the component measuring device shown in FIG. 1 is further opened beyond a normal open position.

FIG. 5 is a partial front sectional view showing a state where the lid of the component measuring device shown in FIG. 1 is further opened beyond a normal open position.

FIG. 6 is a longitudinal sectional view showing a configuration example of a chip used in the present invention.

7 is a longitudinal sectional view showing a state before a chip is mounted on a chip holder of the component measuring device shown in FIG. 1.

8 is a longitudinal sectional view showing a state where a chip is mounted on a chip holder of the component measuring device shown in FIG. 1.

9 is a longitudinal sectional view showing a configuration example of a main part in the component measuring device shown in FIG.

10 is a longitudinal sectional view showing a configuration example of a main part in the component measuring device shown in FIG.

11 is a longitudinal sectional view showing a configuration example of a main part in the component measuring device shown in FIG.

FIG. 12 is a longitudinal sectional view showing a configuration example of a main part in the component measuring device shown in FIG.

13 is a block diagram showing a circuit configuration of the component measuring device shown in FIG.

FIG. 14 is a flowchart showing an operation (including a part of the operation of the operator) of the component measuring device shown in FIG. 1;

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Component measuring device 2 Casing 21 Opening 22 Contact part 23 Support bracket 24 Fixed concave part 25 Support piece 26 Through hole 27 Locking part 3 Lid body 30 Attached part 31 Swing axis 32 Hook 33 Hook part 4 Chip holder 41 Mounting hole 42 Storage space 43 Ventilation pipe 44 Long hole 45 Support flange 5 Chip 51 First chip body 511 Middle cavity 512 Flange part 513 Contact part 514 Depression 515 Entry hole 516 Introduction guide 517 Guide hole 518 Tip opening 52 Second chip body 521 Middle cavity section 522 Bottom section 523 Hole 53 Hub 54 Puncture needle 55 Test paper 56 Test paper fixing member 561 Guide passage 6 Puncture means 61 Plunger 611 Joint 612 Locking projection 613 Elastic piece 62 Lock release member 63 Seal member 64 First Coil spring 65 2nd coil spring 7 reduced Pressure means 71 Suction tube 72 Pump 73 Branch tube 74 Solenoid valve 8 Measurement means 81 Measurement block 82 Light emitting element 83 Light receiving element 9 Control system 91 Control means 92 Amplifier 93 A / D converter 94 Display section 95 Battery 10 Guide bar 11 Mounting member DESCRIPTION OF SYMBOLS 12 Slider 121 Sliding part 122 Connecting part 123 Arm part 124 Spring support part 125 Engaging convex part 13 Eject pin 14 Attachment member 15 Swing link 151 Connecting pin 152 Notch part 16 Working link 17 Coil spring 18 Spring holding 200 Fingertip 210 Puncture Parts S101 to S111 Step

 ────────────────────────────────────────────────── ─── Continued on the front page F term (reference) 2G045 AA01 AA15 AA25 CA25 CB30 DA31 DA80 FA01 FA11 FA34 FA40 FB01 FB15 GC12 HA09 HA14 JA01 JA02 JA07 JA20 4C038 KK10 KL01 KL07 KM00 KY04 TA02 UE03 UE10

Claims (5)

[Claims] 1. A component measuring device for detachably mounting a chip provided with a means for collecting and holding a body fluid, and measuring an amount and / or property of a predetermined component in the collected body fluid, wherein the chip is inserted. A casing having an opening to be opened, and a lid provided so as to be displaceable with respect to the casing and covering the opening so as to be openable and closable, and discharging the mounted chip with the operation of opening the lid. A component measuring device having an ejection mechanism. 2. The device according to claim 1, wherein the lid is provided so as to be displaceable between a closed position, a first open position, and a second open position with respect to the casing. When the lid is in the first open position, the chip can be mounted, and when the lid is displaced from the first open position to the second open position, the chip is ejected. The component measuring device according to claim 1, wherein the component measuring device is configured to: 3. A component measuring device for detachably mounting a chip provided with a means for collecting and holding a bodily fluid, and measuring an amount and / or property of a predetermined component in the collected bodily fluid, wherein the chip is inserted. An opening, an eject mechanism for ejecting the chip after being inserted, and a casing having a mounting portion for mounting the lid, and a lid having a portion to be mounted and covering the opening so as to be openable and closable, The lid is provided so as to be displaceable with respect to the casing by displaceably attaching the attached portion to the attachment portion, and the lid is interlocked with the displacement of the attached portion. An engaging portion that moves in conjunction with the engaging portion is provided in the eject mechanism, after the engaging mechanism engages with the engaging portion. In conjunction with the displacement of the attached part The component measuring device is configured to discharge the chip by moving the eject mechanism by moving. 4. A component measuring device for detachably mounting a chip provided with a means for collecting and holding a bodily fluid, and measuring an amount and / or property of a predetermined component in the collected bodily fluid, wherein the chip is inserted. An opening, an eject mechanism for ejecting the chip after being inserted, and a casing having a mounting portion for mounting the lid, and a lid having a portion to be mounted and covering the opening so as to be openable and closable, The lid is provided so as to be displaceable with respect to the casing by attaching the attached portion to the attachment portion so as to be rotatable with respect to the attachment portion, and the lid is interlocked with the axis rotation of the attached portion. An engagement portion that rotates coaxially is provided, and the eject mechanism has an engaged portion that axially rotates coaxially with the engagement portion after engaging with the engagement portion. The engaged portion is provided A component measuring apparatus characterized in that the ejecting mechanism is operated and the chip is ejected by rotating the shaft coaxially in coordination with the shaft rotation of the mounting portion. 5. The lid is displaceably provided in a closed posture, a first open posture, and a second open posture with respect to the casing. In the open position, the chip can be inserted into the opening, and when the lid is displaced from the first open position to the second open position, the chip is ejected. 5. The component measuring device according to claim 3, wherein the lid is in the first open position until the engagement portion engages with the engaged portion. 6.