JP2001525829A - 不安状態およびストレス状態を治療するための1−アリール(アラルキル)−イミダゾリン−2−オンの使用 - Google Patents
不安状態およびストレス状態を治療するための1−アリール(アラルキル)−イミダゾリン−2−オンの使用Info
- Publication number
- JP2001525829A JP2001525829A JP54979698A JP54979698A JP2001525829A JP 2001525829 A JP2001525829 A JP 2001525829A JP 54979698 A JP54979698 A JP 54979698A JP 54979698 A JP54979698 A JP 54979698A JP 2001525829 A JP2001525829 A JP 2001525829A
- Authority
- JP
- Japan
- Prior art keywords
- imidazolin
- anxiety
- general formula
- aralkyl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.一般式I: [式中、 Xは、水素、C1〜C4−アルキル、C1〜C4−アルコキシ、トリフルオロメチル 、ハロゲンであり、 R1もしくはR2は、C1〜C4−アルキル、シクロアルキル、ヘテロアルキルであ るか、または R1およびR2は、一緒になって炭素原子2〜6個を有するアルキレン基であり、 その際、−CH2−基は酸素、窒素または硫黄によって置換されていてもよく、 かつCH2−基の数は0(1−アリール−イミダゾリン−2−オン)もしくは1 (1−アラルキル−イミダゾリン−2−オン)である]の化合物ならびにその製 薬学的に認容性の塩の、不安状態およびストレス状態の治療用の薬剤の製造のた めの使用。 2.葛藤により誘発される不安状態の治療のための請求項1記載の一般式Iの 化合物の使用。 3.少なくとも1種の一般式Iの化合物またはその製薬学的に認容性の塩なら びに、場合により担持物質および/または助剤を含有する抗不安作用を有する薬 剤。
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19721580A DE19721580A1 (de) | 1997-05-23 | 1997-05-23 | Verwendung von 1-Ar(alk)yl-imidazolin-2-one zur Behandlung von Angst- und Spannungszuständen |
DE19721580.7 | 1997-05-23 | ||
PCT/DE1998/001343 WO1998052548A2 (de) | 1997-05-23 | 1998-05-14 | Verwendung von 1-ar(alk)yl-imidazolin-2-one zur behandlung von angst- und spannungszuständen |
US09/079,802 US5994347A (en) | 1997-05-23 | 1998-05-15 | For a process for treatment of anxiety and tension |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2001525829A true JP2001525829A (ja) | 2001-12-11 |
JP4838403B2 JP4838403B2 (ja) | 2011-12-14 |
Family
ID=26036759
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP54979698A Expired - Lifetime JP4838403B2 (ja) | 1997-05-23 | 1998-05-14 | 不安状態およびストレス状態を治療するための1−アリール(アラルキル)−イミダゾリン−2−オンの使用 |
Country Status (25)
Country | Link |
---|---|
US (1) | US5994347A (ja) |
EP (1) | EP0979083B1 (ja) |
JP (1) | JP4838403B2 (ja) |
CN (1) | CN1150901C (ja) |
AR (1) | AR012746A1 (ja) |
AT (1) | ATE246926T1 (ja) |
AU (1) | AU745536B2 (ja) |
BG (1) | BG63378B1 (ja) |
BR (1) | BR9809666A (ja) |
CA (1) | CA2291075C (ja) |
DE (2) | DE19721580A1 (ja) |
DK (1) | DK0979083T3 (ja) |
ES (1) | ES2205516T3 (ja) |
HU (1) | HUP0003108A3 (ja) |
IL (1) | IL132652A0 (ja) |
NO (1) | NO325346B1 (ja) |
NZ (1) | NZ500849A (ja) |
PL (1) | PL193589B1 (ja) |
PT (1) | PT979083E (ja) |
RU (1) | RU2203055C2 (ja) |
SK (1) | SK284258B6 (ja) |
TR (1) | TR199902815T2 (ja) |
TW (1) | TW579294B (ja) |
WO (1) | WO1998052548A2 (ja) |
ZA (1) | ZA984197B (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2168969A2 (en) | 2002-08-02 | 2010-03-31 | Teva Pharmaceutical Industries Ltd. | Racemization and Enantiomer Separation of Clopidogrel |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050070537A1 (en) | 2002-10-10 | 2005-03-31 | Chris Rundfeldt | Use of dihydroimidazolones for the treatment of dogs |
AU2004255414A1 (en) * | 2003-07-11 | 2005-01-20 | Boehringer Ingelheim Vetmedica Gmbh | Method of treating or preventing central nervous system disorders with compounds having selectivity for the alpha 3 subunit of the benzodiazepine receptor |
AU2005272802B2 (en) | 2004-08-11 | 2009-07-02 | Intercontinental Great Brands Llc | Sensate compositions and delivery systems therefor |
US9820988B2 (en) | 2014-03-24 | 2017-11-21 | Boehringer Ingelheim Vetmedica Gmbh | Treatment of epileptic disorders in feline animals |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4044021A (en) * | 1971-10-21 | 1977-08-23 | American Cyanamid Company | Tetrasubstituted imidazolidine diuretics useful in the treatment of hyperaldosteronism |
DE19532668A1 (de) * | 1995-09-05 | 1997-03-06 | Dresden Arzneimittel | Neue, antikonvulsiv wirkende 1-Ar(alk)yl-imidazolin-2-one, die in 4-Stellung einen disubstituierten Amin-Rest enthalten, und Verfahren zu deren Herstellung |
US5869481A (en) * | 1995-09-05 | 1999-02-09 | Arzneitmittelwerk Dresden G.M.B.H. | Anticonvulsive 1-ar(alk)ylimidazolin-2-ones and process for making |
-
1997
- 1997-05-23 DE DE19721580A patent/DE19721580A1/de not_active Withdrawn
-
1998
- 1998-05-14 DE DE59809285T patent/DE59809285D1/de not_active Expired - Lifetime
- 1998-05-14 TR TR1999/02815T patent/TR199902815T2/xx unknown
- 1998-05-14 CA CA002291075A patent/CA2291075C/en not_active Expired - Lifetime
- 1998-05-14 WO PCT/DE1998/001343 patent/WO1998052548A2/de active IP Right Grant
- 1998-05-14 CN CNB988053748A patent/CN1150901C/zh not_active Expired - Lifetime
- 1998-05-14 NZ NZ500849A patent/NZ500849A/en unknown
- 1998-05-14 BR BR9809666-4A patent/BR9809666A/pt not_active Application Discontinuation
- 1998-05-14 PL PL98337090A patent/PL193589B1/pl not_active IP Right Cessation
- 1998-05-14 PT PT98933532T patent/PT979083E/pt unknown
- 1998-05-14 HU HU0003108A patent/HUP0003108A3/hu unknown
- 1998-05-14 EP EP98933532A patent/EP0979083B1/de not_active Expired - Lifetime
- 1998-05-14 DK DK98933532T patent/DK0979083T3/da active
- 1998-05-14 AT AT98933532T patent/ATE246926T1/de not_active IP Right Cessation
- 1998-05-14 IL IL13265298A patent/IL132652A0/xx not_active IP Right Cessation
- 1998-05-14 JP JP54979698A patent/JP4838403B2/ja not_active Expired - Lifetime
- 1998-05-14 SK SK1584-99A patent/SK284258B6/sk not_active IP Right Cessation
- 1998-05-14 RU RU99128109/14A patent/RU2203055C2/ru active
- 1998-05-14 ES ES98933532T patent/ES2205516T3/es not_active Expired - Lifetime
- 1998-05-14 AU AU83326/98A patent/AU745536B2/en not_active Expired
- 1998-05-15 US US09/079,802 patent/US5994347A/en not_active Expired - Lifetime
- 1998-05-19 ZA ZA9804197A patent/ZA984197B/xx unknown
- 1998-05-20 TW TW087107848A patent/TW579294B/zh not_active IP Right Cessation
- 1998-05-22 AR ARP980102409A patent/AR012746A1/es not_active Application Discontinuation
-
1999
- 1999-10-29 NO NO19995300A patent/NO325346B1/no not_active IP Right Cessation
- 1999-11-04 BG BG103859A patent/BG63378B1/bg unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2168969A2 (en) | 2002-08-02 | 2010-03-31 | Teva Pharmaceutical Industries Ltd. | Racemization and Enantiomer Separation of Clopidogrel |
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