JP2001318348A - Contact lens mounting liquid - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a contact lens mounting liquid which not only has excellent wetting properties in wearing contact lenses but has usability as well and is useful as the mounting liquid for not only hard contact lenses but soft contact lenses as well. SOLUTION: This contact lens mounting liquid contains (A) a polyvinyl-base high-polymer compound and (B) a cellulose-base high-polymer compound, has a viscosity of 5 to 25 mPa.s and more preferably further contains (C) cyclodextrins and is usable as the soft contact lens mounting liquid as well.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a contact lens mounting solution, and more particularly, to a contact lens mounting solution which improves water wettability of a contact lens, sufficiently improves the feeling of wearing the contact lens, and has good wearability. The present invention relates to a contact lens mounting liquid that can be used as a liquid.

[0002]

2. Description of the Related Art A contact lens, regardless of whether it is hard or soft, exhibits its original function by covering the lens surface with tears. If the lens surface is not covered with tears, undesired situations such as cloudy vision and a poor feeling of wearing are caused. Therefore, in order to form a stable tear film on the lens surface, various methods for improving the water wettability of the contact lens have been studied.

As methods for improving the water wettability of contact lenses, for example, (1) a method of immersing in an aqueous solution containing polyvinyl alcohol having a specific property (Japanese Patent Laid-Open No. 10-130448), and (2) a contact lens surface A method of forming a hydrophilic film with a cellulose polymer compound is known.

However, in the method (1),
The viscosity of the mounting solution is not sufficient, and a good feeling of wearing cannot be obtained. In the method (2), a sticky feeling due to the cellulosic polymer compound or the like is caused, and especially, the soft contact lens is difficult to wear. There was a problem.

[0005]

SUMMARY OF THE INVENTION The present invention has been made in view of the above circumstances, and improves the wettability of a contact lens, sufficiently improves the feeling of wearing the contact lens, and furthermore, wears the contact lens with good wearability. The purpose of the present invention is to provide a novel contact lens mounting solution that can be used as a soft contact lens mounting solution that has not been studied with conventional contact lens mounting solutions. .

[0006]

Means for Solving the Problems and Embodiments of the Invention The present inventors have developed a contact lens mounting solution having the above-mentioned preferable properties, and have conducted intensive studies to achieve the above object. As shown in Examples and Comparative Examples, by adjusting the viscosity of the contact lens mounting liquid so that the viscosity at a temperature of 30 ° C. is 5 to 25 mPa · s,
We found that we improved the feeling of wearing contact lenses,
As a result of further intensive studies, the use of a polyvinyl polymer compound and a cellulose polymer compound as a thickener in combination with a contact lens mounting solution using a polyvinyl polymer compound or a cellulose polymer compound alone was compared. As a result, it has been found that the water wettability and wearing feeling of the contact lens are remarkably improved, and a contact lens mounting liquid which is particularly suitable as a soft contact lens mounting liquid can be obtained.

The present inventors have further studied the contact lens mounting solution having such a composition. When the polyvinyl polymer compound is used as a component of the contact lens mounting solution, the polyvinyl polymer compound is A small amount of vinyl-based monomer is included, and it has been found that a monomer odor may be generated due to this, and as a result of various studies on means for suppressing the generation of the monomer odor, in addition to the above components, When cyclodextrins are blended, the present inventors have found that even if a small amount of a vinyl monomer derived from a polyvinyl polymer compound is contained in the composition, it is possible to suppress the generation of monomer odor due to this, and have accomplished the present invention. .

That is, the present invention is characterized in that it comprises (A) a polyvinyl polymer and (B) a cellulose polymer, and has a viscosity at 30 ° C. of 5 to 25 mPa · s. More preferably, the present invention further provides a contact lens mounting solution containing (C) cyclodextrins. Here, the contact lens mounting liquid of the present invention is more preferably used particularly as a soft contact lens mounting liquid.

Hereinafter, the present invention will be described in more detail. The contact lens mounting solution of the present invention contains (A) a polyvinyl polymer and (B) a cellulose polymer, and more preferably, Further, it contains (C) cyclodextrins. Here, the type of the polyvinyl polymer compound as the first essential component of the present invention is not particularly limited, and examples thereof include polyvinyl alcohol, polyvinyl pyrrolidone, carboxyvinyl polymer, and polyvinyl methyl ether. ,
These can be used alone or in combination of two or more. In the case of the present invention, among these, polyvinyl alcohol and polyvinyl pyrrolidone are preferable, and polyvinyl alcohol is particularly preferable.

The properties of the polyvinyl polymer compound of the present invention are not particularly limited, and any polyvinyl polymer compound that is usually used for ophthalmology can be used without any particular limitation. The molecular weight is not particularly limited, but usually, when the weight average molecular weight is lower than 5,000, the monomer odor often becomes strong. Therefore, those having a weight average molecular weight of 5,000 or more are preferable. On the other hand, if the average molecular weight is too high, for example, the mountability to a soft contact lens may be deteriorated. Therefore, usually, the one having a weight average molecular weight up to about 50,000 is preferable. Therefore, the polyvinyl polymer compound of the present invention preferably has a weight average molecular weight of 5,000 to 50,000, more preferably 10,000 to 40,000. In the case of polyvinyl alcohol, the degree of saponification is 85 to 9
0 mol% of partially saponified compounds are widely used in ophthalmic compositions.

The amount of the polyvinyl polymer compound in the contact lens mounting solution of the present invention is not particularly limited, but is usually 0.1 to 3 w / v% based on the entire mounting solution.
(Mass / volume%) is preferable, and more preferably 0.5 to 2 w / v%. If the amount is too low or too high, the water wettability may not be sufficiently improved.

The type of the cellulosic polymer compound as the second essential component of the present invention is not particularly limited, and examples thereof include methylcellulose, hydroxyethylcellulose, hydroxypropylmethylcellulose, and the like.
Examples thereof include hydroxyethylmethylcellulose, hydroxypropylcellulose, ethylcellulose, carboxymethylcellulose and the like, and these can be used alone or in an appropriate combination of two or more. In the case of the present invention, among these, methyl cellulose and hydroxypropylethyl cellulose are particularly preferred.

The properties of the cellulosic polymer compound of the present invention are not particularly limited, and any cellulosic polymer compound that is usually used for ophthalmology can be used without any particular limitation. The molecular weight is not particularly limited, but in consideration of adjusting the viscosity of the contact lens mounting solution of the present invention as described below, the weight average molecular weight is usually about 50,000 to 500,000. Particularly, those having about 70,000 to 350,000 are preferable.

The amount of the cellulosic polymer compound in the contact lens mounting solution of the present invention is not particularly limited, but the weight average molecular weight is about 50,000 to 500,000 and the viscosity at 30 ° C. is 5 to 25 mPa · s. For this purpose, it is usually preferable to set the amount to 0.1 to 5 w / v% based on the entire mounting liquid.

As described above, the contact lens mounting solution of the present invention comprises, in addition to the components (A) and (B),
Furthermore, when cyclodextrins are blended as the component (C), even if the mounting solution contains a trace amount of a vinyl monomer derived from the polyvinyl polymer compound of the component (A), generation of monomer odor due to this is prevented. It is more preferable because it can be suppressed.

Here, the cyclodextrins include:
Cyclodextrin and cyclodextrin derivatives having a saccharide cyclic structure of cyclodextrin necessary for inclusion are exemplified. Examples of cyclodextrin include α-cyclodextrin, β-cyclodextrin, γ-cyclodextrin, and δ-cyclodextrin. Examples of the cyclodextrin derivative include methylated cyclodextrin, hydroxyethylated cyclodextrin, maltosyl-α-cyclodextrin, hydroxyethyl-β-cyclodextrin, and triacetyl-β-cyclodextrin. Α-cyclodextrin, β-cyclodextrin, γ-cyclodextrin, δ-cyclodextrin, methylated cyclodextrin, and hydroxyethylated cyclodex. Strings and the like are more preferably used, and these may be used alone or in combination of two or more.

The amount of the cyclodextrins in the contact lens mounting solution of the present invention is not particularly limited.
3 to 1 w / v%, more preferably 0.03 to 0.5 w / v
v% is preferred. If the amount is less than 0.03 w / v%, the effect of cyclodextrins may be insufficient. If the amount exceeds 1 w / v%, a problem may occur in the storage stability of the solution under low-temperature conditions. is there.

The contact lens mounting solution of the present invention contains 30
The viscosity at 5 ° C. is 5 to 25 mPa · s, especially 5 to 20 m
It is necessary to adjust to Pa · s. If the viscosity is less than 5 mPa · s, the viscosity is too low and does not become a cushion, so that the wearing feeling of the contact lens does not improve. If the viscosity exceeds 25 mPa · s, stickiness occurs,
On the contrary, the wearing feeling of the contact lens is deteriorated, and especially when used as a soft contact lens mounting liquid, the mounting property is deteriorated.

In the present invention, the viscosity can be measured according to the viscosity measurement method described in the Japanese Pharmacopoeia.

As long as the effects of the present invention are not impaired, the contact lens mounting solution of the present invention may further contain, in addition to the above-mentioned components, various additional components commonly used in ordinary ophthalmic preparations, such as preservatives, isotonic agents, and the like. Agents, buffers, stabilizers, fragrances, amino acids and the like can be contained.

The preservatives include, for example, benzalkonium chloride, chlorhexidine gluconate, sorbic acid, chlorobutanol, paraoxybenzoate and the like. As the tonicity agent, for example, potassium chloride,
Sodium chloride, calcium chloride, magnesium sulfate,
Propylene glycol, polyethylene glycol, glycerin and the like can be mentioned. Examples of the buffer include citric acid, boric acid, sodium hydrogen phosphate, sodium hydrogen carbonate, glacial acetic acid and the like.

Examples of the stabilizer include sodium edetate, polyoxyethylene (20) sorbitan monooleate, and polyoxyethylene (60) hydrogenated castor oil. Examples of the flavor include camphor, menthol, borneol, eucalyptus oil, geraniol, fennel oil, bergamot oil and the like. Examples of the amino acid include aspartate, aminoethylsulfonic acid, sodium chondroitin sulfate and the like. These can be added in appropriate amounts as long as the effects of the present invention are not impaired.

The pH of the contact lens mounting solution of the present invention is not particularly limited.
It is desirable to keep in the range of 8.

The method for preparing the contact lens mounting solution of the present invention is not particularly limited. For example, the above-mentioned components can be mixed with water such as sterilized purified water or ion-exchanged water, or a mixed solvent of alcohol such as ethanol. And then, if necessary, the pH of the solution is adjusted with a pH adjuster or an isotonic agent.
H, the osmotic pressure and the like are appropriately adjusted, then the viscosity is checked and adjusted, and then the solution is sterilized by filtration to obtain a contact lens mounting liquid.

The contact lens mounting solution of the present invention is not particularly limited as to the types of contact lenses that can be applied, and can be applied to both hard contact lenses and soft contact lenses. The method of use is not particularly limited. For example, by using a normal amount of a conventional contact lens mounting solution according to a conventional method, various types of hard contact lenses, oxygen-permeable hard contact lenses, soft contact lenses, etc. When the contact lens is worn, excellent wettability is exhibited, and not only can the conjunctiva and the cornea be prevented from being damaged due to drying of the contact lens surface, but also the usability at the time of wearing is good.

[0026]

EXAMPLES Next, the present invention will be described more specifically with reference to examples and comparative examples, but the present invention is not limited by the following examples.

Examples 1 to 8 and Comparative Examples 1 to 5 Each component in the table was sterilized and purified according to a conventional method so as to have the compositions shown in Tables 1 and 2 (compounding unit w / v%). After dissolving in water, each solution was subjected to aseptic filtration to prepare Examples 1 to 8 and Comparative Example 1.
~ 5 contact lens mounting solutions were prepared. The following tests were performed on each of the obtained preparations. The results are shown in Tables 1 and 2. The contact angle was used as an index of water wettability.

<Method of Measuring Viscosity> The viscosity of each solution at 30 ° C. was measured using an E-type viscometer (Tokyo Keiki Co., Ltd.).

<Measurement method of contact angle> A hard contact lens ["AIMY EX", manufactured by Asahi Kasei AIMY Co., Ltd.] is immersed in each solution for 1 hour, rinsed with purified water, and then contact angle meter (Kyowa Interface Science) And the contact angle was measured by a droplet method.

<Wearing comfort test> Contact lens user 7
A person (one hard contact lens user, three oxygen-permeable hard contact lens users, three soft contact lens users) wears each contact lens in the usual manner using each contact lens mounting solution. Thereafter, the wearing feeling of the contact lens was evaluated based on the following evaluation criteria.

[Evaluation Criteria for Wearing Feet] 5: The wearing feeling is greatly improved as compared with the case where no mounting liquid is used. 4: The wearing feeling is improved as compared with the case where no mounting liquid is used. The feeling of wearing is slightly improved as compared to the above. 2: The feeling of wearing is not changed as compared with the case where the mounting liquid is not used. 1: The feeling of wearing is worse as compared with the case where the mounting liquid is not used.

If the average value in the above five-step evaluation is 4 or more, ◎ is given; if it is 3 or more and less than 4, ○ is given; if it is 2 or more and less than 3, Δ is given; The usability was evaluated. The contact lens mounting liquid is preferably ○ or more, and more preferably ◎.

[0033]

[Table 1] Note) PVA Co-Senol EG-05: Polyvinyl alcohol (Nippon Synthetic Chemical Industry Co., Ltd.) saponification degree 86.5-89 mol%, weight average molecular weight 30,000 HPMC 60SH4000: hydroxypropyl methylcellulose ("Metroze 60SH4000", Shin-Etsu Chemical Co., Ltd.)
Co., Ltd.) Weight average molecular weight 350,000 HPMC 60SH50: hydroxypropyl methylcellulose (“Metroze 60SH50”, Shin-Etsu Chemical Co., Ltd.) Weight average molecular weight 100,000 MC SM4000: Methylcellulose (“Metroze SM40
00 ", Shin-Etsu Chemical Co., Ltd.) Weight average molecular weight 350,000

[0034]

[Table 2] Note) PVA Co-Senol EG-05: Polyvinyl alcohol (Nippon Synthetic Chemical Industry Co., Ltd.) saponification degree 86.5-89 mol%, weight average molecular weight 30,000 HPMC 60SH4000: hydroxypropyl methylcellulose ("Metroze 60SH4000", Shin-Etsu Chemical Co., Ltd.)
Co., Ltd.) Weight average molecular weight 350,000 HPMC 60SH50: hydroxypropyl methylcellulose (“Metroze 60SH50”, Shin-Etsu Chemical Co., Ltd.) Weight average molecular weight 100,000 MC SM4000: Methylcellulose (“Metroze SM40
00 ", Shin-Etsu Chemical Co., Ltd.) Weight average molecular weight 350,000

According to the results shown in Tables 1 and 2, the contact lens mounting solution containing the polyvinyl polymer and the cellulose polymer of the present invention has a small contact angle and excellent water wettability. Is recognized. In addition, it is recognized that the contact lens mounting solution of the present invention having a viscosity at 30 ° C of 5 to 20 mPa · s improves the feeling of wearing the contact lens. In each of the contact lens mounting liquids, the odor of the vinyl monomer derived from the polyvinyl polymer compound was suppressed.

[0036]

The contact lens mounting solution of the present invention not only has excellent wettability when mounting a contact lens, but also has excellent usability, and can be used as a mounting solution not only for hard contact lenses but also for soft contact lenses. Useful.

Claims (3)

[Claims] (A) a polyvinyl polymer compound;
(B) a cellulosic polymer compound,
A solution for mounting a contact lens, which has a viscosity at 0 ° C. of 5 to 25 mPa · s. 2. The contact lens mounting solution according to claim 1, further comprising (C) a cyclodextrin. 3. The contact lens mounting liquid according to claim 1, which is a soft contact lens mounting liquid.