JP2001249073A - Optical sensor unit, optical sensor apparatus using the same and living body component detector - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an optical sensor unit easy to handle and a sensor apparatus using the same. SOLUTION: The optical sensor unit is constituted of a sensor element for detecting an object to be measured and a prism for allowing the light emitted from a light source to be incident on the sensor element to transmit the reflected light from the sensor element to a detector and the sensor element and the prism are covered with a shading member permitting only the light of the light path of incidence light and reflected light to pass.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention generally relates to a sensor device for detecting an object to be measured and outputting a predetermined signal.
In particular, the present invention relates to a sensor device using light in the field of biosensors utilizing an enzyme reaction such as an antibody antigen reaction or a catalytic reaction.

[0002] The present invention generally relates to a sensor device for detecting an object to be measured and outputting a predetermined signal, and more particularly to a sensor device which sends a liquid to a sensor element and requires replacement of the sensor element. About the improvement of the part.

[0003]

2. Description of the Related Art As optical sensors, semiconductor infrared sensors, pyroelectric infrared sensors, resonant mirror sensors, surface plasmon sensors, and the like have been put to practical use, and are mainly used to detect human bodies, objects, and objects to be measured in samples. And so on. Among them, surface plasmon sensors can measure the refractive index of a medium near the surface of a sensor element, and are therefore used for chemical sensors such as gas sensors, biosensors using an antibody-antigen reaction, etc. It has already been put into practical use as a biosensor that is immobilized on a sensor element and detects and quantifies proteins, nucleic acids, and other biological substances to which the antibody specifically binds.

[0004]

The optical sensor device which has already been used is composed of only a prism and a sensor element surface as a unit as disclosed in Japanese Patent Application Laid-Open No. 64-6842. The measurement is performed several times, but in this structure, the unit must be replaced for each measurement, so the work is complicated, and the important prism part for measuring as an optical sensor is exposed. For this reason, care must be taken during replacement of the unit or during transportation, and furthermore, there is a problem that detection cannot be performed due to dirt or scratches.

Further, the sensor device disclosed in Japanese Patent Laid-Open No. 4-501462 has a structure in which only the sensor element is replaced. Therefore, it is necessary to repair the inside of the device and, in some cases, replace the entire member.

Further, the flow path for supplying a sample to the surface of the sensor element provided in the sensor device main body needs to be disassembled when the flow path is clogged or the like due to entry of foreign matter into the flow path. It took time. In addition, since the sensor element surface did not have a flow path for reacting with the test sample and holding the sample, there was liquid dripping when replacing the sensor element, liquid leakage after replacing the sensor element, etc. The element could not be easily replaced.

Accordingly, it is an object of the present invention to provide an optical sensor unit which is easy to handle and to provide a sensor device using the optical unit.

Another object of the present invention is to provide a sensor device in which the sensor element can be easily replaced and the inside of the flow path can be easily repaired.

[0009]

According to the first aspect of the present invention,
A sensor element for detecting an object to be measured, and a prism for making incident light generated from a light source incident on the sensor element and transmitting reflected light reflected by the sensor element to a detector, and the sensor element And the prism is covered with a light blocking member that allows only light on the optical path of incident light and reflected light to pass through.

In the present invention, since the sensor element and the prism are integrally formed, the positioning of the sensor element and the prism can be easily performed, and the sensor element and the prism are covered with a light shielding member. It has a protection function to prevent contact, and can be handled so that the sensor element and the prism surface are not scratched or stained, and can be easily transported and transported as an optical sensor unit.

According to a second aspect of the present invention, in the optical sensor unit according to the first aspect, the sensor element has a flow path on a surface of which a fluid containing an object to be measured can be exchanged. .

In the present invention, since the fluid containing the object to be measured on the surface of the sensor element is provided so that the fluid can be exchanged, it is not necessary to exchange the optical sensor unit for each measurement, and the detection can be performed a plurality of times. Become.

In addition, since the sensor element surface has a flow path through which the fluid containing the object to be measured can be exchanged, the flow path is filled with a fluid for preserving the sensor element surface, and the sensor element is stored in a state ready for use. It is possible to measure immediately without exchanging the fluid containing the object to be measured and the fluid for preserving the surface of the sensor element through the flow path without cleaning or drying the sensor element before measurement. The object can be measured.

According to a third aspect of the present invention, in the optical sensor unit according to any one of the first to second aspects, the optical sensor unit includes an optical path adjusting member for adjusting an optical path of light from a light source. Features.

In the present invention, since the optical sensor unit is provided with an optical path adjusting member for adjusting the optical path of the light from the light source, the positions of the sensor element, the prism, and the optical path adjusting member can be fixed as the optical sensor unit. It is possible to determine the position of a member that must maintain a certain positional relationship in order to measure.

Further, by providing an optical path adjusting member, it is possible to select light from a light source such as scattered light or parallel light.

According to a fourth aspect of the present invention, in the optical sensor unit according to the third aspect, the optical path adjusting member is a condenser lens.

In the present invention, since the light from the light source can be condensed and radiated to the sensor element by forming the light path adjusting member as a condenser lens, the light amount of the light source used for measurement can be reduced. Therefore, inexpensive or small devices can be used, and the sensor device can be reduced in size and cost.

According to a fifth aspect of the present invention, in the optical sensor unit of the third aspect, the optical path adjusting member is a light shielding plate having a pinhole.

In the present invention, by using a light shielding plate having a pinhole in the optical path adjusting member, it is possible to adopt a configuration in which the size and focal length of the lens itself are not taken into account.
The size of the sensor device can be reduced.

A light-shielding plate having a pinhole can be processed by operations such as sputtering, vacuum deposition, etching and pressing while the pinhole is masked, so that it is cheaper and easier than a lens. Can be made.

According to a sixth aspect of the present invention, in the optical sensor unit according to any one of the third to fifth aspects, the optical path adjusting member is disposed between the light source and the sensor element. A concave portion is formed at an angle of incident light for exciting the SPR, and is arranged in the concave portion.

In the present invention, the light path adjusting member is disposed between the light source and the sensor element, so that the light source and the sensor element can be left as they are, depending on the application, depending on the application. It is possible to change to the light shielding plate described in item 5.

Further, a concave portion is formed at an angle of incident light for exciting the SPR in the light shielding member according to claim 1, and the optical path adjusting member is disposed in the concave portion so that the optical path adjusting member is located inside the concave portion. It is possible to determine the incident angle of the incident light and the irradiation position on the sensor element only by arranging them at the positions.

According to a seventh aspect of the present invention, in the optical sensor unit according to any one of the first to second aspects, the prism is made of a light-transmitting resin.

In the present invention, by forming the prism with a light-transmitting resin, it becomes possible to process the prism with a metal mold at the time of forming the prism, thereby improving the moldability.
Since the prism can be manufactured in large quantities, the prism can be manufactured at low cost.

Also, since the shape of the prism can be freely selected by improving the moldability, a positioning pin for adjusting the position in the optical sensor unit can be set on the prism itself, or the prism can be used as an optical path adjusting member. In addition to the function of transmitting incident light and reflected light to the prism, a position determination function and irradiation position adjustment function are added, such as providing a concave part for fixing an optical lens, a light shielding plate having a pinhole, etc., and providing an irradiation position adjustment function. It is possible to do.

According to an eighth aspect of the present invention, in the optical sensor unit according to any one of the first to second aspects, the light shielding member includes a positioning member for sealingly contacting the prism and the sensor element. It is characterized by being provided.

In the present invention, since the prism and the sensor element are provided with the positioning member for hermetically sealing and contacting each other, the prism and the sensor element can be easily connected to the prism simply by disposing them in the light shielding member. Since the sensor element can be positioned and fixed, there is no need for a jig or the like for aligning the prism and the sensor element when assembling the optical sensor unit, and the inspection process of the position of the prism and the sensor element after assembly is omitted. it can. Therefore, the optical sensor unit can be manufactured quickly and inexpensively.

According to a ninth aspect of the present invention, in the optical sensor unit according to any one of the first to second aspects, the light shielding member prevents contamination of the prism surface on an optical path of light reflected from the sensor element. It is characterized in that a functional unit is provided.

In the present invention, since the light shielding member is provided with a functional portion for preventing dirt on the prism surface on the optical path of the reflected light from the prism, it becomes impossible to directly contact the prism surface. It is possible to prevent the prism surface from being damaged or soiled during handling of the optical sensor unit at the time of assembling or replacing the device, or during transportation.

The invention according to claim 10 is the invention according to claims 1 to 1
0, in the optical sensor unit according to any one of the above, the light-shielding member is a side member 1) communicating with an upper surface portion provided with a flow path for sending an object to be measured to the sensor element, and a bottom surface portion on which a prism is installed. And a communicating side member 2).

In the present invention, the upper surface member provided with the flow path for sending the object to be measured to the sensor element and the lower surface member provided with the prism are respectively connected to the side members so that the upper, lower, left and right sides can be formed. Since the four-sided member can be composed of two members, the number of members can be reduced, the manufacturing cost of the member itself and the number of assembly steps of the optical sensor unit can be reduced, and the optical sensor unit can be manufactured at low cost. .

Further, since the number of assembly members is small, an assembly error generated at the time of assembly can be reduced, and assembling accuracy can be improved.

According to an eleventh aspect of the present invention, there is provided a sensor element for detecting an object to be measured, and an incident light generated from a light source is made incident on the sensor element, and the light reflected by the sensor element is transmitted to the detector. An optical sensor unit A) comprising a prism and the sensor element, wherein the prism is covered with a light blocking member for blocking light, and a light source B).
And a detector C that receives the light reflected from the sensor element)
Are arranged on the same member having a positioning member.

In the present invention, the optical sensor unit A), the light source B) and the detector C) for receiving the light reflected from the sensor element are arranged on the same member having a positioning member. It is possible to accurately determine the positions of the optical sensor unit A) important for measurement as a sensor device, the light source B) and the detector C).

According to a twelfth aspect of the present invention, in the optical sensor device according to the eleventh aspect, the optical sensor unit is configured to be detachable from a positioning member.

In the present invention, since the optical sensor unit is configured to be detachable from the positioning member, it is possible to replace the sensor element or the prism when the surface of the sensor element is deteriorated or when the prism is dirty or scratched. If necessary, it can be easily replaced.

Further, since the optical sensor unit can be attached and detached, there is no fear that the fluid remaining on the surface of the sensor element adheres to the hand or stains other members.

According to a thirteenth aspect of the present invention, in the optical sensor device according to any one of the eleventh and twelfth aspects, the optical sensor unit is configured to be detachable from a positioning member. It is characterized in that a detachable guiding member is provided on the contacting positioning member.

In the present invention, since the positioning member that comes into contact with the optical sensor unit is provided with the detachable guiding member, the optical sensor unit is guided by the detachable guiding member to a position where the optical sensor unit can be easily detached. In addition, it is possible to perform the operation reliably.

According to a fourteenth aspect of the present invention, in the optical sensor device of the eleventh aspect, the optical sensor unit is provided with a structure that is joined to a positioning member on a side surface.

In the present invention, the structure in which the optical sensor unit is joined to the positioning member is provided on the side surface, so that only the operation of joining the structural part to be joined when the optical sensor unit is mounted on the positioning member and the positioning member are performed. Thus, the position of the optical sensor unit is determined, and the optical sensor unit is securely fixed.

According to a fifteenth aspect of the present invention, in the optical sensor device according to any one of the eleventh to fourteenth aspects, the same member includes an inflow portion for injecting a measurement object into the optical sensor unit and the optical sensor unit. Characterized by having a flow path comprising a discharge section for discharging from the container.

In the present invention, the optical sensor unit and the optical sensor device are provided by having a flow path including an inflow portion for flowing the object to be measured into the optical sensor unit and a discharge portion for discharging the object from the optical sensor unit. Can be connected, and the fluid can be sent to the surface of the sensor element in the optical sensor unit.

According to a sixteenth aspect of the present invention, in the optical sensor device according to the fifteenth aspect, the flow path is configured to be detachable from the surface of the optical sensor unit.

In the present invention, since the flow path is configured to be detachable from the surface of the optical sensor unit, it is possible to connect a pipe for sending a fluid from outside the optical sensor unit to the surface of the sensor element. The optical sensor unit can be easily removed and can be easily replaced when the optical sensor unit is replaced.

According to a seventeenth aspect of the present invention, in the optical sensor device according to the eleventh aspect, the light source is configured such that a lens and a luminous body are integrally formed.

In the present invention, since the light source is formed integrally with the lens and the illuminant, the positional relationship between the lens and the illuminant can be fixed at a constant value, and a member for fixing the lens at a constant position can be provided. Since it is not required, the number of assembling steps of the optical sensor device can be reduced and the size of the device can be reduced.

The invention according to claim 18 is a biological component detection device, which is a sensor device capable of measuring a quantitative amount of an object to be measured in a test sample, wherein the optical device according to any one of claims 11 to 17 is provided. A sensor device, a liquid sending unit for sending a test sample to the optical sensor device, and a solution storage unit for cleaning a surface of the sensor element are provided.

In the present invention, the optical sensor device, the liquid sending means for sending a test sample to the optical sensor device, and the solution storing section for cleaning the surface of the optical sensor unit are provided, so that the measurement with the optical sensor device is possible. The test sample can be measured only by inserting the test sample to be performed into the biological component detection device.

Further, since the optical sensor unit is provided with the solution storing section for cleaning the surface, the sensor element surface can be cleaned after measuring the test material, and the measurement can be repeated.

The invention according to claim 19 is a urine component inspecting apparatus, wherein a urine collecting means provided on a toilet, a conveying means for conveying urine from the urine collecting means to a sensor device, and a urine sent from the conveying means. 19. The optical sensor means according to claim 11, for quantifying a measurement target contained in the optical sensor device, a solution storage means for cleaning a sensor element surface of the optical sensor device, and a numerical value quantified by the optical sensor device. And a display means for displaying.

According to the present invention, only by urinating the urine to the urine collecting means provided on the toilet, the conveying means for conveying the urine to the sensor device conveys the urine to the sensor device, and measures the object to be measured contained in the urine. Then, it is possible to display the measurement result numerically.

Further, since a solution storing means for cleaning the surface of the sensor element is provided, the surface of the sensor element after the measurement can be cleaned, and the measurement can be repeated.

According to a twentieth aspect of the present invention, there is provided a sensor having a sensor element for detecting an object to be measured, and a flow path formed integrally on the surface of the sensor element and through which the object to be measured flows. Unit.

According to the twentieth aspect, when the measurement object flows through the flow path, the measurement object is detected by the sensor element. For this reason, it is possible to detect continuously by flowing the measurement object continuously. Also,
Since the flow path is formed integrally with the surface of the sensor element, it is not necessary to incorporate the sensor unit into the device.

According to a twenty-first aspect of the present invention, there is provided a sensor unit wherein the inlet and the outlet of the flow path are provided at a position higher than the surface of the sensor element.

According to the twenty-first aspect, since the inlet and the outlet of the flow path are provided at a position higher than the surface of the sensor element, the measurement object whose flow has stopped stays on the surface of the sensor element. Therefore, even if the flow of the measurement object stops, the surface of the sensor element is not immersed in the solution containing the measurement object and does not dry.

According to a twenty-second aspect of the present invention, there is provided a measurement / measurement system which measures a user's excrement obtained by a toilet operation in a toilet and provides information relating to the user's health management based on the measurement. A health management device performing a providing operation, comprising: an acquisition unit provided in a toilet, for acquiring the excreta; a sensor element for detecting a predetermined component contained in the excretion acquired by the acquisition unit; and the sensor A sensor unit formed integrally with the surface of the element, and a flow path for the excrement to flow, and a measuring unit for measuring a predetermined physical quantity of a component detected by the sensor unit, It is characterized by having.

According to the invention of claim 22, when the excrement flows through the flow path, a predetermined component contained in the excrement is detected by the sensor element. For this reason, by continuously flowing the excrement, it is possible to continuously detect a predetermined component contained in the excrement. In addition, since the flow path is formed integrally with the surface of the sensor element, the time required for assembling the sensor unit into the device can be saved.

Moreover, according to the health management device of the present invention,
Obtain measurement results from excretions excreted in daily life. That is, it can be measured in daily life regardless of the specialized institution. Therefore, measurement results can be obtained with sufficient frequency to capture changes in health status that progress very slowly or improve, thereby effectively preventing, early detecting and treating various diseases. be able to.
The excrement may be excrement by urine, stool, or other stool action. Further, sweat, saliva, ovulation, menstrual blood, and the like may be used according to the purpose. The predetermined physical quantities related to the excrement include the volume of the excrement itself,
In addition to mass and density, the content and concentration of various components contained in the excrement are exemplified.

Further, the invention according to claim 23 is characterized in that a washing means for washing a flow path formed in the sensor unit is provided.

According to the twenty-third aspect of the present invention, the flow path formed in the sensor unit is cleaned by the cleaning means, so that the measurement can be repeated.

According to a twenty-fourth aspect of the present invention, the excrement is urine, and the measurement relates to at least one of urine sugar, protein, occult blood, sodium ion, and uric acid.

The measurement data exemplified here has the following meanings. Urine sugar can be used for prevention, discovery, treatment, etc. of diabetes. Protein is also called urinary albumin and can be effectively used for early detection of diabetic nephropathy. In particular, it is said that diabetic nephropathy is discovered very early and will not be cured without treatment, and therefore, detection of urinary albumin is highly effective. It is known that in the early stage of diabetic nephropathy, a small amount of albumin is excreted in urine. Therefore, if such a small amount of albumin can be detected as measurement data, it can be used for early detection of diabetic nephropathy. Naturally, it is also effective in finding non-diabetic nephropathy.

[0067] Occult blood is one of the signs of inflammation, calculus and the like occurring in the kidney, ureter, urethra and the like. In the early stage, it is not possible to confirm at a glance that urine is contaminated with blood, and the individual is in a state called asymptomatic hematuria without any subjective symptoms. In the health management device of the present invention, if occult blood is used as measurement data, occult blood can be detected at the stage of such asymptomatic hematuria, so that it can be used for early detection and treatment of the above various diseases. .

Sodium is measurement data that is a measure of the daily intake of salt. It is well known that salt causes factors such as hypertension and heart failure. For the prevention and treatment of these diseases, it is preferable to control the salt intake to an appropriate value. However, salt intake is not always in line with taste, and foods that do not feel so salty often contain large amounts of salt. On the other hand, it is known that it is almost proportional to the intake of sodium salt in urine. Therefore, if sodium is detected as the measurement data, the amount of intake of salt can be grasped and utilized for its control.

Uric acid is known as a causative substance such as gout. It is said that about 80% of uric acid is excreted in the urine in less than 80% of the daily amount. Therefore, by measuring uric acid in urine, it is possible to estimate the uric acid level in the body,
It can be used to prevent and treat gout and other diseases.

The various measurement data described here is merely an example, and other various measurement data can be used as the measurement target of the health management device of the present invention. Of course, a plurality of measurement data may be measured.

According to a twenty-fifth aspect, a first storage means for sequentially storing the measurement results and a plurality of measurement results stored in the first storage means are used for the measurement / providing operation. It is characterized in that statistical processing is included.

The measurement data includes various errors caused by daily activities of the user, but these errors usually fall within a predetermined range. According to the twenty-fifth aspect, the measurement data can be sequentially stored, and the statistical processing is performed based on the stored measurement results, so that the influence of the error can be reduced to the extent that it can be used for health management. Therefore, according to the twenty-fifth aspect, it is possible to acquire data that can be used for health management without increasing the number of measurement items or performing complicated correction processing on the measurement data itself. Also,
According to the twenty-fifth aspect, in order to obtain significant measurement data, it is possible to avoid the complexity of adjusting the conditions for acquiring the excrement, and also to avoid the complexity of inputting the acquisition conditions. be able to. Of course, it is also possible to input an acquisition condition, and to perform statistical processing in consideration of this.

The following statistical processing can be performed. As described above, it is generally considered that the error of the measurement data falls within a predetermined range of variation. Conversely, when measurement data that deviates from the predetermined variation is obtained, it can be assumed that a cause other than a normal error factor, that is, some abnormality has occurred in the user's health condition. Therefore, the standard deviation and the average value are calculated, and the measurement data that is out of the predetermined variation range defined based on the standard deviation with respect to the average value is extracted, and the value and the occurrence frequency of the extracted measurement data are determined. It may be calculated. In this way, the health condition can be managed based on these values and the frequency of occurrence.

The statistical processing method and the number of results required to obtain an appropriate result can be variously set according to the contents of the measurement data. For example, for measurement data having large daily fluctuations such as urine sugar, measurement data having similar acquisition conditions is selected from data acquired over a plurality of days, and the daily change is statistically obtained. It can be. Statistical processing can also be performed on measurement data with relatively small daily fluctuations based on all obtained data. The statistical processing can be executed by various well-known methods such as calculation of an average value and a standard deviation.

Further, according to the present invention, there is provided a data transfer means capable of exchanging the result of the measurement between the plurality of health management devices.

In everyday life, the place where an individual takes a stool is not limited to one place. It is common to use flights at various places, such as at home or on the go. If the health management device is provided with the above-described data transfer means, measurement data can be exchanged between a plurality of devices. Can be managed. As a result, personal analysis data can be acquired more frequently, and more appropriate health management can be performed.

Various means can be applied as the data transfer means. For example, it is also possible to adopt a configuration in which data can be exchanged between health management devices by wired or wireless communication. In this case, in addition to the mode of directly exchanging data between the health management devices, the mode of exchanging data via a network is possible. As the data transfer means, a method of recording personal measurement data on a portable recording medium such as a flexible disk may be adopted.

In the case where a data transfer means is provided, it is more desirable that data can be exchanged with a device other than the health management device, for example, a general-purpose computer.
In this way, more appropriate health management can be performed based on the measurement data.

In the twenty-seventh aspect, there is provided identification means for identifying a plurality of users, and second storage means for storing the result of the measurement in a form in which a correlation with the identified users is secured. It is characterized by having.

Since the health management device of the present invention is provided in a toilet, there is a high possibility that a plurality of users use one health management device in daily life. In such a case, according to claim 27, the measurement data can be stored while ensuring a correlation with the user. Therefore, even when a plurality of persons use the apparatus, it is possible to appropriately manage the health of each individual.

Various means can be applied to the user identification means. For example, the user may perform an operation for identifying himself / herself. A method of selecting oneself from a list of users input in advance to the health management device may be used, or an ID for identifying oneself may be input at the time of use. The operation unit of the health management device may have a function of measuring a fingerprint. Furthermore, when it is assumed that the user's gender difference, age difference, etc. are greatly apart, such as at home, weight,
The user may be identified based on information such as capacitance.

In the twenty-seventh aspect, the measurement data may be different depending on the user. In this way, since only the measurement data required by each person can be acquired, the cost required for the measurement and the capacity of the storage means for storing the measurement data can be saved.

The health management device of the present invention can set various measurement targets, but it is particularly preferable to target measurement data capable of detecting a long-term change in the user's health condition.

For diseases such as lifestyle-related diseases, which do not progress rapidly in about one or two days, but gradually progress over a long period of time, frequent treatments are required for their prevention and treatment. It is desirable to perform an inspection. ADVANTAGE OF THE INVENTION According to the health management apparatus of this invention, since analysis data can be acquired appropriately in daily life, an individual can perform a test | inspection with sufficient frequency without feeling a heavy burden. Therefore, if measurement data capable of detecting a long-term change in the user's health condition is targeted, it can be effectively used for prevention, early detection and treatment of lifestyle-related diseases and the like. The term “long term” refers to a term suitable for evaluating the progress of the disease depending on the type and condition of the disease. It may be a few days, or a long term such as weeks or months.

The health management device according to the present invention, which relates to the configuration of the device, has a configuration in which the adoption unit is detachable from the rim portion of the Western style toilet in the embodiment of the invention. On the other hand, the device may have a portable size. In addition to making the entire device portable, portable devices can be configured in various modes. For example, only a unit for collecting and storing urine and a unit for storing conditions for collecting urine may be configured to be portable, and urine analysis itself may be performed ex post fact by the installed health management device main body. Further, a simple method may be employed as a sensor for measuring each component in urine. Furthermore, you may comprise as an apparatus which limited the component to be analyzed.
In this way, measurement data can be acquired without selecting a toilet, and measurement data that can be used for health management can be acquired more frequently and continuously. Further, since the device can be prepared for each individual, there is an advantage that the user can be easily specified.

It is also possible to incorporate the urine collecting unit into the toilet seat. This makes it possible to stably attach the urine collection unit to the Western style toilet. Naturally, by replacing the toilet seat itself, it is possible to later attach the health management device to an already installed Western-style toilet. In addition, it goes without saying that the health management device may be built in a Western-style toilet or cabinet. The urinal to which the urine collection unit is attached is not limited to a Western urinal.

According to a twenty-eighth aspect of the present invention, there is provided a sensor device comprising a biosensor element that reacts with a test sample and a detector that detects a reaction amount of the biosensor element. A flow path between the entrance opening and the exit opening, a sensor unit having a biosensor element disposed in the flow path, and a mounting unit to which the sensor unit is attached and detached, an entrance opening, An outlet corresponding to the outlet opening, a main unit having an inlet, a fluid supply path to the biosensor element by attaching the inlet opening and the outlet, and a biosensor by attaching the outlet opening and the inlet It is characterized in that it is configured to form a fluid discharge path from the element.

In the present invention, since the sensor unit and the main unit are formed as separate members, when the clogging occurs in the flow path, the fluid supply path and the fluid discharge path can be easily disassembled. Can be repaired easily.

Further, in the sensor unit, since the biosensor element is disposed in the flow path between the inlet opening and the outlet opening, no liquid dripping occurs even when the sensor element is replaced.
The sensor element can be easily replaced.

The invention according to claim 29 is characterized in that, in the above invention, the outlet and the inlet are configured such that when the outlet is attached to the entrance opening, the entrance is simultaneously attached to the exit opening. .

In the present invention, the sensor unit can be easily mounted on the main unit when the sensor unit is replaced.

According to a thirtieth aspect of the present invention, in the above invention, the fluid supply passage is sealed by attaching the inlet opening and the outlet, and the fluid discharge passage is sealed by attaching the outlet opening and the inlet. It is characterized by the following.

In the present invention, the sensor unit can be securely mounted on the main unit even after the replacement operation of the sensor unit, so that there is no fear of liquid leakage of the sample or the like.

The invention according to claims 31 and 32 is characterized in that the outlet and the inlet are respectively formed at the tips of the convex members, and these convex members can be inserted into the entrance opening and the exit opening. The two convex members are characterized in that they are movable with respect to each other.

In the present invention, since the outlet and the inlet are formed at the tip of the convex member, the flow path can be reliably connected by the inlet opening and the outlet opening.

According to a thirty-third aspect of the present invention, in the above-mentioned invention, the flow path has a central portion having a rectangular parallelepiped internal volume, and an upstream portion and a downstream portion having a flow path area larger than the central portion. The biosensor element is characterized in that the surface faces the central part.

[0097] In the present invention, since the upstream and downstream portions have a larger flow area than the flow path on the surface of the biosensor element, liquid exchange on the surface of the biosensor element can be reliably performed.

According to a thirty-fourth aspect of the present invention, in the above-mentioned invention, a prism for making incident light generated from a light source incident on a biosensor element and transmitting reflected light reflected by the biosensor element to a detector is provided. In addition, in the present invention, in which the sensor unit includes the prism, the sensor unit includes the prism, so that the prism does not directly touch a member of the sensor device. The dirt and breakage of the prism can be prevented.

According to a thirty-fifth aspect of the present invention, a biosensor element that reacts with a test sample, a detector that detects the amount of the reaction, and incident light generated from a light source are incident on the biosensor element. A prism for transmitting the reflected light reflected by the detector to the detector, wherein the sensor unit in which the biosensor element and the prism are arranged in a fixed positional relationship, and the sensor unit are attached and detached. A main body side unit having a mounting portion,
And the sensor unit is detachable from the main unit.

In the present invention, since the sensor unit is detachable from the main unit, when the biosensor element in the sensor unit is deteriorated, the biosensor element can be easily replaced by replacing the sensor unit. Can be.

[0101]

Embodiments of the present invention will be described below in detail with reference to the drawings. FIG. 1 is a side sectional view showing the entire configuration of the optical sensor unit of the first embodiment.

As shown in FIG. 1, the optical sensor unit includes a sensor element 1, a prism 2, and an optical path adjusting member 3.
A sealing member 4 that forms a flow path to seal between the sensor element and the liquid sending section, and a side member 5 that communicates with an upper surface portion provided with a flow path for sending an object to be measured to the sensor element. And a side member 6 communicating with a bottom surface on which the prism is installed.

In order to perform measurement as a sensor device, an object to be measured is fed onto the sensor element 1, and light from the light source 10 is adjusted by the optical path adjusting member 3 to the position where the solution is sent, and the inside of the prism 2 is adjusted. And the light reflected from the sensor element 1 is received by the detector 11, detected, and quantified if necessary.

At this time, correct measurement cannot be performed unless the positions of the sensor element 1 and the prism 2 and the incident angle and irradiation position of the light adjusted by the optical path adjusting member 3 are fixed at correct positions.

In the optical sensor unit shown in FIG. 1, the position of the prism 2 is determined by pressing the prism 2 against the reference surface 20 on the right side of the side member 6 communicating with the bottom surface. Then, the sensor element 1 is placed on the prism 2 from above, and in this state, the sensor element 1 is pressed down from above with a side member 5 communicating with the upper surface and assembled. At this time, the side member 5 is provided with a positioning member 7, which plays a role of pressing the prism 2 against the reference surface of the side member 6 during assembly.
Position can be accurately fixed.

When the prism 2 is made of a light-transmitting resin, a positioning pin (not shown) is provided on the prism 2 itself, and a concave portion (not shown) corresponding to the positioning pin is provided on the side member 6. Since there is a degree of freedom in the shape of the prism 2, for example, a concave portion (not shown) is provided in the prism 2 and a convex portion (not shown) corresponding to the concave portion is provided in the side surface member 6, or the like. The position of the prism 2 can be fixed easily and accurately.

The optical path adjusting member 3 is formed with a concave portion on the side surface member 6 in accordance with the incident angle of light, and the hole diameter of the concave portion and the outer diameter of the optical path adjusting member 6 are formed so as to be press fit. Therefore, the light incident angle can be fixed only by arranging the optical path adjusting member 3 in the concave portion of the side member 6.

Further, as for the light irradiation position, the positions of the concave portion and the prism are fixed so as to be an appropriate light irradiation position. Therefore, the light path adjusting member 3 is pressed into the concave portion of the side member 6 and fixed. By doing so, the light irradiation position can be accurately fixed.

Since the light path adjusting member 3 is independent from the light source 1 and the optical sensor unit as shown in FIG. 1, the light path adjusting member 3 may be provided with the condensing lens or the pinhole according to the application. Or the light path adjusting member 3 alone can be replaced.

[0110] The application here means that the condenser lens uses, for example, a small LED or an inexpensive LED having a small light source output, and the light-shielding plate having a pinhole is used when the optical sensor device is miniaturized. Since the lens and the lens are expensive, the cost of the optical sensor device may be reduced.

An antibody is immobilized on the surface of the sensor element 1, and the surface of the sensor element 1 must be filled with a preservative solution in order to keep the antibody ready for measurement. The sensor element 1 includes a seal member 4 that forms a flow path to seal between the sensor element 1 and the liquid sending section.
Is pressed against the sensor element 1 from above by a side member 5 communicating with an upper surface provided with a flow path for sending an object to be measured to the sensor element 1, thereby forming a flow path 8 on the surface of the sensor element 1. In this state, the preservation solution is caused to flow through the channel 8 and stored, whereby the antibody on the surface of the sensor element 1 can be preserved.
In the present optical sensor unit, after the preservation liquid flows on the surface of the sensor element 1, the preservation liquid does not flow out of the flow path 8, and the flow provided on the side member 5 so that air bubbles do not enter the surface of the sensor element 1. A lid (not shown) is provided on the road and plugged, so that the inside of the flow path unit 8 is always liquid-sealed.

As described above, the side members 5 and 6 play a role of preserving the surface of the sensor element 1.
Another role is to protect the prism 2. The entrance surface, the reflection surface, and the exit surface of the prism 2 must be mirror surfaces, and if a scratch or dirt adheres to those surfaces, it greatly affects the measurement result. Therefore, by incorporating the prism 2 into the side members 5 and 6, the prism 2 is protected from external contact or damage due to impact.

By incorporating the sensor element 1 and the prism 2 in the light shielding member of the optical sensor unit, the sensor element 1 and the prism 2 can be protected and stored. Therefore, when the optical sensor unit is being transported or transported. To
Since the sensor element 1 and the prism 2 are not damaged or stained, and the surface of the sensor element 1 is always in a measurable state, transportation, transportation, and replacement of the optical sensor unit can be performed very quickly and conveniently.

FIGS. 2 to 5 are views showing the entire configuration of the optical sensor device of the first embodiment.

As shown in FIGS. 2 to 5, the optical sensor device includes an optical sensor unit 9, a light source 10, a detector 11, an optical sensor unit 9 attaching / detaching member 12, and an optical sensor unit 9. Flow path section 13 for allowing an object to flow in, and positioning member 14 for optical sensor unit 9
And a light source 10, a detector 11, and the same member 15 on which the positioning member 14 for the optical sensor unit 9 is disposed.

In the present optical sensor device, the positional relationship among the optical sensor unit 9, the light source 10, and the detector 11 affects the measurement result of the sensor device. Therefore, the light source 10 and the detector 11 are directly fixed to the same member 15 for positioning. The optical sensor unit 9 is provided with the sensor element 1 and needs to be detachable in order to be replaceable. Accordingly, since the optical sensor unit 9 cannot be directly fixed to the same member 15, the same member 15 is provided with a positioning member 14 for the optical sensor unit 9 in order to reliably fix the optical sensor unit 9 at a fixed position.
Is fixed.

The positioning member 14 comprises three pedestals of the same size. The optical sensor unit 9 can be positioned in the X-axis direction by pressing the side surface of the optical sensor unit 9 against three points on the upper surface of the pedestal.

Further, as shown in FIG. 5, two pins of the three pedestals of the positioning member 14 have pins whose tips are thin. As a counterpart, as shown in FIG. 1, the optical sensor unit 9 is provided with a structure 16 to be joined to the positioning member. The reason why the tip of the positioning member 14 is thin is to smoothly join the structure 16 to be joined. In addition, by providing a portion having an enlarged diameter by chamfering the entrance of the structure 16 to be joined, the joining between the positioning member 14 and the structure 16 to be joined can be performed smoothly. By joining the structure 16 to be joined to the positioning member 14, the optical sensor unit 9 can be positioned in the Y-axis direction and the Z-axis direction.

The same member 15 is provided with an attachment / detachment guide member 12 for assisting attachment / detachment of the optical sensor unit 9. A spring (not shown) is used for the attachment / detachment guide member 12, and a force is constantly applied in a direction to detach the optical sensor unit 9 from the same member 15.

As shown in FIG. 4, when the optical sensor unit 9 is mounted on the detachable guide member 12 and pushed to a certain portion in the direction of the same member 15 by human power or the like, the lock is activated, and the detachable guide member 12 is fixed in place. You. The optical sensor unit 9 attached to the attachment / detachment guide member 12 is a positioning member 1 fixed to the same member 15 as the joining structure 16 in the optical sensor unit 9 while the attachment / detachment guide member 12 is locked.
4 are joined to pins having thinned ends, and thereafter, when the detachment guide member 12 is locked, the optical sensor unit 9 is pressed against the three pedestals of the positioning member 14, and the position of the optical sensor unit 9 is determined. .

As shown in FIG. 3, the optical sensor unit 9
Are fixed to the same member 15, the optical sensor unit 9
From above, a flow path section 13 including an inflow section for flowing the object to be measured and a discharge section for discharging the measurement object descends, and is connected to a flow path provided on the upper surface of the optical sensor unit 9. The flow path unit 13 is disposed on the same member 15,
It can move only in the Z-axis direction. A spring (not shown) is used similarly to the attachment / detachment guide member 12, and a force is always applied in a direction in which the flow path portion 13 is detached from the optical sensor unit 9, and is pushed into the optical sensor unit 9 by human power or the like. It has a structure where a certain part is locked.

Since a liquid such as an object to be measured flows through the pipe section between the optical sensor unit 9 and the flow path section 13, it is necessary to take measures to prevent liquid leakage. Therefore, in the present optical sensor device, an O-ring is used for the nozzle 17 of the flow path portion 13,
The O-ring is inserted into the flow path of the optical sensor unit 9 while the O-ring is crushed to prevent liquid leakage, or an elastic sealing material 4 such as silicon rubber is provided in the optical sensor unit 9 on the upper surface of the optical sensor unit 9. When the flow path 13 descends and is inserted into the flow path on the upper surface of the optical sensor unit 9, the nozzle 17 of the flow path 13 crushes the upper surface of the sealing material 4 to prevent liquid leakage. I took the structure to do.

In order to remove the optical sensor unit 9 which is a consumable member, as shown in FIG.
Is pressed against the same member 15 to lock it, the flow path 13 is moved from above toward the optical sensor unit 9 to connect the pipes, and the optical sensor device in a state where the flow path 13 is locked is shown in FIG. As described above, first, the lock of the channel portion 13 is released, the channel portion 13 is moved upward, and the pipe is cut.

Next, as shown in FIG.
2 is released, and the optical sensor unit 9 is separated from the same member 15.

Thereafter, as shown in FIG. 5, the optical sensor unit 9 is taken out from the detachable guide member 12, a new optical sensor unit 9 is installed in place of the optical sensor unit 9, and the lid provided on the upper surface of the unit is removed. Is performed, the replacement of the optical sensor unit 9 ends.

The present optical sensor device has a lock release button 19. When the lock release button 19 is pressed once, first, the lock of the flow path unit 13 is released and the flow path unit 13 moves upward, and then the lock of the detachable guiding member 12 is released, and the optical sensor unit 9 is the same. It is separated from the member 15.

As the light source 10, a unit in which a collimating lens for processing scattered light into parallel light with an LED was used was used.

Since the LED and the collimating lens are unitized, a compact light source 10 can be manufactured without taking up space.

Further, by using a collimating lens for processing the scattered light into parallel light, the light intensity of the LED can be reduced.
It becomes possible to make it weaker than using scattered light. At this time, since the light incident on the optical sensor unit 9 is parallel light, the incident light intensity is almost the same in any part. It can be easily supplemented compared to using.

FIG. 6 is a diagram showing the overall configuration of the biological component detecting device according to the first embodiment.

As shown in FIG. 6, the biological component detecting device comprises an optical sensor device 21, a liquid sending means 22, a solution storing section 23, a control board 24, a result display board 25, and a heat buffer 26. And

In order to measure an object to be measured using the above-described biological component detection device, the object to be measured is injected into the liquid feeding means 22 using an automatic sample injection device or the like. The injected measurement object is sent to the optical sensor device 2 by the liquid sending means 22.
Liquid is sent to 1. The liquid sending means 22 controls the speed and amount of liquid sent by the control substrate 24. The measurement object sent by the liquid sending means 22 is measured by the optical sensor device 21. The measurement result is processed and digitized by the control board 24. The digitized measurement result is transmitted from the control board 24 to the result display board 25, and the result is displayed as a numerical value on the result display board.

A buffer for diluting the solution containing the object to be measured and for cleaning the surface of the sensor element 1 and a solution for calculating the measured value detected by the sensor as a quantitative value are stored in the solution storing section 23. A calibration liquid containing a measurement target and having a known concentration, and a regenerating liquid for dissociating the bond between the measurement target and the capture substance on the surface of the sensor element 1 are stored.

The liquid sending means 22 serves to send the solution containing the object to be measured to the optical sensor device 21 and also transfers the buffer solution, the calibration solution, and the regenerating solution stored in the solution storage section 23 to the optical sensor device. It has a role of sending the liquid to 21. Liquid sending means 2
A valve (not shown) is provided in 2 and the solution to be sent is switched by switching the valve. Switching of the valve is controlled by the control board 24.

In order to perform more accurate measurement with the present optical sensor device, it is necessary to keep the temperature of the solution containing the object to be measured sent to the surface of the sensor element 1 at a constant temperature. In the present biological component detection device, the measurement was performed by installing the entire detection device in a space such as a thermostat that can keep the temperature constant. Also,
In order to make the device small and easy, a heat buffer 26 is provided in the bio-line segment inspection device, and the solution to be sent is supplied to the heat buffer 2.
6 and a means for sending the liquid to the optical sensor device after adjusting the temperature to be constant.

FIG. 7 is a diagram showing the entire configuration of the urine component inspection apparatus of the first embodiment, and FIG. 8 is a view showing urine collecting means provided in the urine component inspection apparatus.

As shown in FIG. 7, the urine component testing apparatus communicates with the urine collecting means 27 attached to the toilet, a biological component detecting apparatus 28 for testing urine components, and the urine collecting means and the biological component detecting apparatus. And a pipe 29.

The urine collecting means 27 is provided on the support 271 attached to the toilet body, and swingably around a horizontal rotation axis extending in the transverse direction of the toilet and spaced upward from the upper surface of the rim side. A supported swing arm 272,
Urine collection container 273 carried on the free end of the swing arm
And a drive unit 274 for swinging the swing arm to move the urine collection container between a rest position close to the inside of the toilet rim and a urine collection position located in the toilet bowl space. Depending on the configuration, urine discharged from the user of the inspection device is collected.

The urine collected by the urine collecting means 27 is sent by the liquid sending means 22 in the biological component detecting device 29. Urine collected while being sent to the optical sensor device 21 by the liquid sending means 22 is diluted to a measurable concentration by the buffer solution in the solution storage unit 23. Diluted,
The urine sent into the optical sensor device 21 is measured and then discharged into the toilet. After the measurement, a dissociation solution, a calibration solution, and a buffer solution are sent to the surface of the sensor element 1, and the sensor element 1 is regenerated to a measurable state.

FIG. 9 is a cross-sectional side view showing the entire configuration of the sensor unit for the sensor device of the second embodiment and the connecting members thereof.

The sensor unit and the connecting member are shown in FIG.
As shown in the figure, the flow path 101, the flow path 102, the sensor element 103, the prism 104, the prism fixing lower member 105, the prism fixing upper member 106 having the flow path 101, and the flow path 102 Provided channel fixing member 107
, Sensor element surface sealing member 108, flow path 102
And a connecting portion sealing member 109 for connecting to the flow path 101 provided in the first and second sections.

The sensor element 103 is disposed on the prism 104, and is fixed by applying pressure from above and below by the prism fixing upper member 106 and the prism fixing lower member 105. At this time, the sensor element 10 is placed on the sensor element 103.
3. A flow path 10 for reacting with and holding a test sample on the surface.
A rubber packing 108 is disposed as a ring-shaped sensor element surface sealing member that is opened up and down to form the first member 1. The sealing member 108 is crushed by the prism fixing upper member 106 and the prism fixing lower member 105, Sealed to prevent leakage.

As described above, a unit (hereinafter referred to as a sensor unit) formed by the sensor element 103, the prism 104, the prism fixing upper member 106, the prism fixing lower member 105, and the sensor element surface sealing member 108 ) Connects a pipe with the sensor device main body at an upper opening provided in the flow path 101.

At the bottom of the concave flow path 101, a sensor element surface sealing member 108 forms a side wall and is connected to the flow path formed on the sensor element 103 surface. The solution such as the test sample and the cleaning liquid sent from the opening of the sensor element 103 passes over the surface of the sensor element 103 and reacts with the surface of the sensor element to form a flow path 101.
From the solution outlet.

At this time, the solution sent from the sensor device main body to the sensor unit needs to be sent into the sensor unit so as not to leak and then discharged out of the sensor unit.

Therefore, the flow path fixing member 107 having the flow path 102 is used, and the flow path 102 is used as a connecting part seal member 109 for preventing liquid leakage from the connecting part with the flow path 101. An O-ring was placed. When the O-ring, which is the connecting portion sealing member 109, connects the flow path 102, which is a convex part, to the flow path 101, which is a concave part, the flow path 101
And squeezed by the side surface of the flow path 102, it was possible to prevent liquid leakage from the connecting portion.

A nozzle 121 having a hollow inside for forming the flow path 102 is provided in the flow path fixing member 107, and the inside of the nozzle forms the flow path 102. A gap is provided between the nozzle 121 and a space 172 for containing the nozzle of the flow path fixing member, and is provided to be rotatable in the left-right direction.

FIG. 10 shows a state where the flow path 101 and the flow path 102 are connected.

As described above, when the connection sealing member 109 is used for the flow path 102, a dead space 109A (FIG. 11) is generated at a connection portion with the flow path 101. When a dead space occurs, the solution remains in that portion. If the solution remains in the dead space, it may affect the measurement results. In order to minimize the dead space, a sealing member for a connecting portion is provided in the flow passage 101, and the sealing member is crushed at the tip of the flow passage 102, thereby preventing liquid leakage from the connecting portion.

FIG. 12 is a sectional view of a sensor unit for a sensor device provided with a connecting portion sealing member 10 in a flow path 101 and a side view showing the entire configuration of the connecting member.

An O-ring can be used as the connecting seal member 10 disposed in the flow path 101. In the case of the sensor cell shown in FIG. 12, instead of press-fitting the flow channel 102 and crushing the sealing members with the left and right walls to seal, the flow channel 10 is not used.
1 Since the seal is crushed up and down at the bottom surface and the end of the flow path 102, no pressure is applied when the flow path 101 and the flow path 102 are attached and detached, and the flow path 102 is more smoothly compared to the type in which the seal member is disposed. It is possible to attach and detach.

FIG. 14 is a cross-sectional view of a sensor unit for a sensor device having a tapered structure 111 for connecting the flow path 101 and the flow path 102.

As shown in FIG. 14, the flow path 101 and the flow path 102
In the case where the connecting portion is formed into a tapered structure 111, it is necessary to apply a pressing force to the flow paths 101 and 102 in order to seal the connecting portion. Therefore, an elastic member 113 such as a spring or silicone rubber is disposed above the nozzle member 112 including the flow path 102.

When connecting the flow path 101 and the flow path 102,
The flow channel fixing member 7 including the flow channel 102 was moved to the sensor cell side and connected. At that time, the sensor cell and the flow path fixing member 107 were set to be connected to each other at a distance where a pressing force was applied to the elastic member 113. By doing so, a pressing force is applied when the flow path 101 and the flow path 102 are connected. Therefore, when the connecting portion between the flow path 101 and the flow path 102 has a tapered structure 111, it is possible to prevent liquid leakage from the connecting part.

In the above description, only the case where the connecting portion between the flow path 101 and the flow path 102 has the tapered structure 111 has been described.
The nozzle member 111 is divided into an inflow member and an outflow member, or the elastic member 113 is used also in the sensor device in which the seal member 9 is disposed and the sensor device in which the seal member 110 for the connection portion is disposed in the flow path 101. By doing so, it is possible to improve the sealing performance of the connecting portion.

In the present invention, since the sensor element and the prism are handled as interchangeable optical sensor units,
Replacement of sensor elements and replacement of scratches or dirt on prisms can be performed easily.Furthermore, storage of sensor elements and protection of prisms are possible, and transport, transportation, and replacement of optical sensor units are very quick. It can be performed conveniently.

Further, the sensor device includes many mechanisms such as a detachable pipe and a member for assisting the attachment and detachment of the optical sensor unit, so that the measurement using the detachable optical sensor unit can be performed accurately. And it can be easily performed.

In the present invention, the flow path 1 formed on the sensor element surface and the flow path 2 for supplying and / or discharging the test sample are formed of different members, so that When clogging occurs, it can be easily disassembled and repaired.

Further, since the flow path 1 for holding the test sample is provided on the surface of the sensor element, the sensor element can be easily replaced without dripping even when the sensor element is replaced.

[Brief description of the drawings]

FIG. 1 is a cross-sectional view showing the entire configuration of an optical sensor unit according to the present invention as viewed from a side.

FIG. 2 is a diagram showing an overall configuration of an optical sensor device according to the present invention.

FIG. 3 is a diagram showing an overall configuration of the optical sensor device shown in FIG. 2, showing a mechanism for attaching and detaching a flow path unit to and from an optical sensor unit.

FIG. 4 is a view showing the overall configuration of the optical sensor device shown in FIG. 2, showing a mechanism for attaching and detaching the optical sensor unit from the same member.

FIG. 5 is a diagram showing the entire configuration of the optical sensor device shown in FIG. 2, showing the optical sensor device with the optical sensor unit removed.

FIG. 6 is a diagram showing the overall configuration of a biological component detection device according to the present invention.

FIG. 7 is a diagram showing an entire configuration of a urine component inspection apparatus of the present invention.

FIG. 8 is a diagram showing a urine collecting means provided in the urine component inspection device of the present invention.

FIG. 9 is a cross-sectional view of a sensor unit including a flow path on the surface of a sensor element according to the present invention and a flow path from a sensor device main body side as viewed from a side.

FIG. 10 is a side view showing a state in which a connection portion between the sensor unit-side flow path and the sensor device main body-side flow path of the present invention is sealed with a sealant in the sensor device main body-side flow path.

FIG. 11 is an enlarged view of FIG. 10;

FIG. 12 is a side view showing a state in which a connection portion between the sensor unit-side flow path and the sensor device main body-side flow path of the present invention is sealed using a sealant in the sensor unit-side flow path.

FIG. 13 is an enlarged view of FIG.

FIG. 14 is a side view showing a state in which a connecting portion between the sensor unit-side flow path and the sensor device main body-side flow path of the present invention has a pointed cone structure.

[Explanation of symbols]

DESCRIPTION OF SYMBOLS 1 ... Sensor element, 2 ... Prism, 3 ... Optical path adjustment member, 4
... Seal material, 5 ... Side member communicating with top surface part, 6 ... Side member communicated with bottom part, 7 ... Positioning member, 8 ... Flow path part made by sensor element and seal material, 9 ... Optical sensor unit, 10 ... Light source, 11 ... Detector, 12 ... Removable guiding member,
Reference numeral 13 denotes a flow path for sending the object to be measured to the optical sensor unit, 14 positioning members, 15 identical members, 16
... Junction structure, 17 ... Nozzle, 18 ... Optical sensor unit upper surface flow path, 19 ... Lock release button, 20 ... Reference surface, 21 ... Optical sensor device, 22 ... Liquid feeding means, 23 ... Solution tank, 24 ... Control board , 25 ... Result display board, 26
... heat buffer, 271 ... support, 272 ... swing arm, 2
73 urine collection container, 274 driving means, 101 flow path 1,
102: flow path 2, 103: sensor element, 104: prism, 105: lower member for fixing prism, 106: upper member for fixing prism, 107: member for fixing flow path, 108 ...
Seal member for sensor element surface, 109 ... seal member for connection

 ────────────────────────────────────────────────── ─── Continuing on the front page (72) Inventor Jin Ohara 2-1-1 Nakajima, Kokurakita-ku, Kitakyushu-shi, Fukuoka F-term (reference) 2D037 EB00 2G045 AA16 AA21 AA22 AA36 BB14 CB03 CB04 DA01 DA31 DA51 DB09 FA14 GC10 GC11 HA06 HA09 HA14 JA01 JA07 JA08 2G057 AA02 AB07 AC01 BA05 BD03 BD04 CA05 DC10 EA06 GA05 HB03 JA02 2G059 AA06 BB13 CC16 DD04 DD12 DD17 EE02 FF07 FF08 GG02 JJ12 MM02 PP04 PP06

Claims (35)

[Claims] 1. A sensor element for detecting an object to be measured, and a prism for making incident light generated from a light source incident on the sensor element and transmitting light reflected by the sensor element to a detector. An optical sensor unit, wherein the sensor element and the prism are covered with a light blocking member that allows only light on an optical path of incident light and reflected light to pass. 2. The optical sensor unit according to claim 1, wherein the sensor element has a flow path on a surface of which a fluid containing an object to be measured can be exchanged. 3. The optical sensor unit according to claim 1, further comprising an optical path adjusting member for adjusting an optical path of light from a light source. 4. The optical sensor unit according to claim 3, wherein said optical path adjusting member is a condenser lens. 5. The optical sensor unit according to claim 3, wherein the optical path adjusting member is a light shielding plate having a pinhole. 6. The optical path adjusting member is disposed between a light source and a sensor element, and the optical path adjusting member is provided between the light source and the sensor element.
A concave portion is formed at an angle of incident light for exciting R,
The optical sensor unit according to claim 3, wherein the optical sensor unit is disposed in the recess. 7. The optical sensor unit according to claim 1, wherein the prism is made of a light transmitting resin. 8. The optical sensor according to claim 1, wherein the light shielding member is provided with a positioning member for sealingly contacting the prism and the sensor element. unit. 9. The light-shielding member according to claim 1, wherein a functional portion for preventing dirt on the prism surface is provided on an optical path of the reflected light from the prism. Optical sensor unit. 10. The light-shielding member includes a side member 1) communicating with a top surface provided with a flow path for sending an object to be measured to the sensor element, and a side member 2) communicating with a bottom portion on which a prism is installed. The optical sensor unit according to any one of claims 1 to 9, further comprising a side member (3) for blocking incident light and light other than reflected light. 11. A sensor element for detecting an object to be measured,
A prism for making incident light generated from a light source incident on the sensor element and transmitting reflected light reflected by the sensor element to a detector, wherein the sensor element and the prism are light shielding members for shielding light An optical sensor unit A), a light source B), and a detector C) that receives light reflected from the sensor element are disposed on the same member having a positioning member. Optical sensor device using an optical sensor unit. 12. The optical sensor device according to claim 11, wherein the optical sensor unit is configured to be detachable from a positioning member. 13. The optical sensor unit according to claim 11, wherein the optical sensor unit is configured to be detachable from a positioning member, and the positioning member that comes into contact with the optical sensor unit is provided with a detachable guiding member. To 12
The optical sensor device according to claim 1. 14. The optical sensor device according to claim 11, wherein the optical sensor unit has a structure that is joined to a positioning member on a side surface. 15. The apparatus according to claim 11, wherein the same member has a flow path including an inflow portion for flowing the object to be measured into the optical sensor unit and a discharge portion for discharging the object from the optical sensor unit. The optical sensor device according to any one of claims 14 to 14. 16. The optical sensor device according to claim 15, wherein the flow path is configured to be detachable from a surface of the optical sensor unit. 17. The optical sensor device according to claim 11, wherein the light source has a lens and a luminous body integrally formed. 18. A sensor device capable of measuring the quantity of an object to be measured in a test sample, the optical sensor device according to claim 11, and a sending device for sending the test sample to the optical sensor device. A biological component detection device comprising: a liquid unit; and a solution storage unit for cleaning a surface of the sensor element. 19. A urine collecting means attached to a toilet, a conveying means for conveying urine from the urine collecting means to a sensor device, and a measurement target contained in urine sent from the conveying means is quantified. A urine component inspection device comprising: the optical sensor device described above; a solution storage device for cleaning an optical sensor element surface of the optical sensor device; and a display device for displaying a result detected by the optical sensor device. 20. A sensor, comprising: a sensor element for detecting an object to be measured; and a flow path integrally formed on a surface of the sensor element and through which the object to be measured flows. unit. 21. The sensor unit according to claim 21, wherein an inlet and an outlet of the flow path are provided at a position higher than a surface of the sensor element. 22. Health that measures a user's excrement obtained by a toilet action in a toilet and performs a measurement / providing operation for providing information related to the user's health management based on the measurement. A management device, comprising: an acquisition unit provided in a toilet, for acquiring the excreta; a sensor element for detecting a predetermined component contained in the excrement acquired by the acquisition unit; and a sensor element on a surface of the sensor element. A sensor unit that is integrally formed and includes a flow path through which the excrement flows, and a measuring unit that measures a predetermined physical quantity of the component detected by the sensor unit. Characterized health management device. 23. The health management device according to claim 22, further comprising a cleaning unit that cleans a flow path formed in the sensor unit. 24. The health care device according to claim 22, wherein the excretion is urine, and the measurement is performed using at least one component of urine sugar, protein, occult blood, sodium ion, and uric acid. A health management device characterized by the above. 25. The health management device according to claim 22, wherein the first storage unit sequentially stores the result of the measurement, and the first storage unit stores the measurement / providing operation. A health management device including statistical processing using a plurality of stored measurement results. 26. The health management device according to claim 22, wherein the health management device includes data transfer means capable of exchanging the result of the measurement between the plurality of health management devices. 27. The health management apparatus according to claim 22, wherein the identification result for identifying a plurality of users, and the result of the measurement in a mode in which a correlation with the identified users is ensured. A health management device comprising a second storage means for storing the information. 28. A sensor device comprising a biosensor element that reacts with a test sample and a detector that detects the amount of the reaction, comprising: an inlet opening; an outlet opening; A sensor unit in which the biosensor element is disposed in the flow channel, and a mounting portion to which the sensor unit is attached and detached, the inlet opening, and the outlet opening. An outlet corresponding to the above, comprising a main body side unit having an inlet, by attaching the inlet side opening and the outlet to form a fluid supply path to the biosensor element, by attaching the outlet side opening and the inlet A sensor device configured to form a fluid discharge path from the biosensor element. 29. The sensor device according to claim 28, wherein the outlet and the inlet are configured such that, when the outlet is attached to the entrance opening, the entrance is attached to the exit opening at the same time. 30. The fluid supply passage is sealed by attaching the inlet opening and the outlet, and the fluid discharge passage is sealed by attaching the outlet opening and the inlet. 30. The sensor device according to claim 28. 31. The sensor device according to claim 28, wherein the outlet and the inlet are respectively formed at the tips of the convex members, and these convex members can be inserted into the entrance-side opening and the exit-side opening. . 32. The sensor device according to claim 31, wherein the two convex members are movable relative to each other. 33. The flow path has a central part having a rectangular parallelepiped inner volume, an upstream part and a downstream part having a flow path area larger than the central part, and the biosensor element has a surface thereof. 33. The sensor device according to claim 28, wherein the sensor device faces the central portion. 34. A prism for causing incident light generated from a light source to enter the biosensor element and transmitting reflected light reflected by the biosensor element to the detector. The sensor device according to any one of claims 28 to 33, further comprising a prism. 35. A biosensor element that reacts with a test sample, a detector that detects an amount of the reaction, and an incident light generated from a light source is incident on the biosensor element, and reflected by the biosensor element. A sensor device comprising: a prism for transmitting light to the detector; and a sensor unit in which the biosensor element and the prism are arranged in a fixed positional relationship; and wherein the sensor unit is detached. And a main unit having a mounting portion, wherein the sensor unit is detachable from the main unit.