JP2001002595A - Automated chemical compound synthesizer - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an automated chemical compound synthesizer that can increase working efficiency from automatic synthesis to analysis. SOLUTION: In this automated chemical compound synthesizer, the protocol analysis screen is displayed for showing the synthesis protocol(s) and the analysis schedule(s) (S1); it indicates an arbitrary reaction vessel that is displayed on the protocol analysis screen to set the generation range of the analysis schedule(s) (S2); the input information for the analyzer is input by using the wizard form screen to set the input information (S3); the synthesis protocol is analyzed to take out the input information of the analyzer included in the synthesis protocol (S4); and the analysis schedule for inputting to the analyzer is formed on the basis of the input information taken out of the synthesis protocol (5). Accordingly, the analysis schedule efficiently can be generated.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an automatic synthesizer for automatically generating a synthetic compound, and more particularly to a technique for generating an analysis schedule in an analyzer for analyzing the generated synthetic compound.

[0002]

2. Description of the Related Art Conventional automatic synthesizers used in research fields such as pharmaceuticals, life sciences, chemistry, and materials are:
Equipped with a reaction block in which a number of reaction vessels for performing a synthesis reaction are arranged, and based on a synthesis protocol that is a preset synthesis procedure, dispensing reagents and solvents into each reaction vessel, For example, by heating and vibrating the reaction block, a synthesis reaction in each reaction vessel is promoted, and a synthetic compound is generated in each reaction vessel. Furthermore, conventionally, in the above-mentioned research field, as an integral and inseparable operation after generating a synthetic compound, in order to check whether or not the synthetic compound synthesized in each reaction vessel is made as desired, for example,
Each of these synthetic compounds is analyzed by an analyzer.

[0003] In order to analyze each synthetic compound by the analyzer, first, an operator must analyze various conditions such as analysis conditions of the synthetic compound, control conditions of the analyzer, a sample name of the synthetic compound, and a file name of a storage destination of the analysis result. An analysis schedule is created by inputting the input information for each synthetic compound. Then, by applying each synthesized compound to the analyzer, the analyzer operates according to the analysis schedule and analyzes each synthesized compound.

[0004]

However, the prior art having such a structure has the following problems. In other words, various input information is input to the analyzer for each synthetic compound by referring to the contents of the synthesis protocol used in the conventional automatic synthesizer. And make the series of operations from automatic synthesis to analysis more and more complicated. For this reason, there is a problem that work efficiency from automatic synthesis to analysis is poor due to factors such as an operator's input error and time required for input work.

The present invention has been made in view of such circumstances, and has as its object to provide an automatic synthesizing apparatus capable of improving the work efficiency from automatic synthesis to analysis.

[0006]

The present invention has the following configuration in order to achieve the above object. Claim 1
The invention described in the above is a reaction block in which a plurality of reaction vessels for performing a synthesis reaction are arranged, dispensing means for dispensing a reaction solution to each reaction vessel of the reaction block, a synthesis reaction in the reaction vessel And a synthesis protocol storage means for storing a synthesis protocol for performing, by dispensing and synthesizing a plurality of types of reaction solutions in the reaction vessel based on the synthesis protocol, in the reaction vessel A first input for inputting to an analyzer for analyzing the generated synthetic compound by analyzing a synthesis protocol used for generating the synthetic compound in the reaction vessel in the automatic synthesizer for generating the synthetic compound; Synthesizing protocol analyzing means for extracting information from the synthesizing protocol; and second input information which is input to the analyzer and is not included in the synthesizing protocol. The analysis device analyzes the synthesized compound based on the input information storage means, the first input information extracted from the synthesis protocol, and the second input information read from the input information storage means. And an analysis schedule generation means for generating the analysis schedule.

[0007] The invention described in claim 2 is the first invention.
The automatic synthesizing apparatus according to the above, further comprising input means for inputting the second input information, wherein the input information storage means stores the second input means input by the input means.

[0008] The invention described in claim 3 is the first invention.
Alternatively, the automatic synthesis apparatus according to claim 2, further comprising an instruction unit configured to indicate an arbitrary reaction container in the reaction block,
The synthesis protocol analysis unit extracts first input information for analyzing a synthetic compound generated in an arbitrary reaction vessel from the synthesis protocol, and the analysis schedule generation unit includes the first input information. And an analysis schedule for analyzing a synthetic compound generated in an arbitrary reaction vessel designated by the designation means, based on the second input information.

[Operation] The operation of the present invention is as follows. According to the first aspect of the present invention, based on the synthesis protocol stored in the synthesis protocol storage means, the reaction solution is dispensed into each reaction vessel of the reaction block by the dispensing means to generate a synthetic compound. As a result, for example, different types of synthetic compounds are generated in the respective reaction vessels. The synthesis protocol analysis means analyzes a synthesis protocol used for generating a synthetic compound in the automatic synthesizer, and inputs the first analysis data to the analyzer for analyzing the synthetic compound included in the synthesis protocol. Extract the input information of The input information storage means stores second input information which is input information not included in the synthesis protocol. The analysis schedule generation means operates the analysis device to analyze each synthetic compound based on the first input information extracted by the synthesis protocol analysis means and the second input information read from the input information storage means. An analysis schedule, which is data to be performed, is generated.
The analyzer analyzes each synthetic compound according to the analysis schedule generated by the automatic synthesizer.

According to the second aspect of the present invention, second input information which is input information to be input to the analyzer and is not included in the synthesis protocol is input by the input means. The input information storage means stores the input second input information. The analysis schedule generating means is provided in a data format for operating an analyzer for analyzing each synthetic compound based on the first input information extracted from the synthesis protocol and the input second input information. Generate an analysis schedule.

According to the invention of claim 3, an arbitrary reaction vessel in the reaction block is indicated by the indicating means. The synthesis protocol analyzing means extracts first input information for analyzing a synthetic compound in an arbitrary reaction vessel from the synthesis protocol. The analysis schedule generation means generates an analysis schedule for analyzing a synthetic compound in an arbitrary reaction vessel based on the first input information and the second input information.

[0012]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS One embodiment of the present invention will be described below with reference to the drawings. FIG. 1 is a block diagram showing the overall configuration of an automatic organic synthesis apparatus according to an embodiment of the present invention. FIG. 2 is a plan view showing the configuration of the reaction system of the apparatus of the embodiment. FIG. 3 is a schematic diagram showing a configuration of a main part of a reaction block of the apparatus of the embodiment.

As shown in FIG. 1, the automatic synthesizing apparatus of the embodiment includes a reaction system in which a synthesis reaction is actually performed, and a control system that controls the movement of the reaction system. Hereinafter, the configuration of the reaction system of the example apparatus will be described first.

In the apparatus of the embodiment, a reaction block 1 in which a plurality of reaction vessels 2 for performing a synthesis reaction are arranged, and a plurality of kinds of reaction liquids such as reagents and solvents are provided in a reaction vessel (reaction vessel) 2 in a predetermined manner. And a liquid dispensing unit 3 for dispensing according to the above procedure. As shown in FIG. 2, each reaction vessel 2 is installed in the reaction block 1 in a matrix arrangement in a vertical and horizontal matrix. The number of reaction vessels 2 installed in the reaction block 1 is not limited to a specific number, and may be, for example, several tens to about one hundred such as 96 or 384. In the case of the example apparatus, the reagent and the solvent are dispensed and supplied to the reaction vessel 2 by a common dispensing mechanism, but the reagent and the solvent are dispensed and supplied by different dispensing mechanisms. There may be.

The liquid dispensing section 3 includes a syringe 4 and a syringe moving mechanism 5 for moving the syringe 4 right and left (X), forward and backward (Y), and up and down (Z). The syringe is operated in accordance with a command signal from the control system. The moving mechanism 5 is operated to move the syringe 4 to a required position.

On the other hand, beside the reaction block 1, a large frequently used reagent container (frequently used reagent vial) 6 in which a relatively large amount of used chemical solution is stored, and a relatively small amount of used chemical solution, etc. are stored. A small reagent container (common reagent vial) 7 is provided with a place for setting a required number of the reagent containers. In addition, beside the reaction block 1, there is provided a place for setting a required number of solvent containers (gallon bins) 8 in which the solvents are stored.
Is configured to be connectable to the syringe 4. The frequent reagent container 6, the common reagent container 7, and the solvent container 8 are set in the apparatus by an operator. In addition, these containers 6,
The reagents and solvents stored in 7, 8 correspond to the reaction solution in the present invention.

Each of the vessels 6, 7, 8 and the reaction vessel 2
As shown in FIG. 4, individual position addresses are assigned to the set positions. In FIG. 4, the frequent reagent container 6
6, the regular reagent container 7 is 36, the solvent container 8 is 4,
This shows a case where 96 reaction vessels 2 can be set.
Then, for example, each container 6, 7, 8 and the reaction container are represented by alphabets and numbers attached in the vertical and horizontal directions of the set place (α, β, γ, δ) for each type of each container 6, 7, 8 The position address of each set location (α, β, γ, δ) for each of the two types is determined. Specifically, of the six set locations (α) of the frequent reagent container 6, the position address of the upper left set location in FIG. 4 is α (A, 1). Similarly, the common reagent container 7
Of the 36 set positions (β), the position address of the lower right set position in FIG. 4 is β (D, 9). The position address of the second set place is γ (B, 1), and among 96 set places (δ) of the reaction vessel 2, the position address of the set place at the lower right of FIG. 4 is δ (H, 1). Become.

When a chemical solution is dispensed and supplied to the reaction container 2, as shown by a dotted line in FIG. 1, the syringe 4 is supplied to the frequently used reagent container 6 or the common reagent container 7 in which the drug solution to be dispensed is stored. After the reagent is moved to the position and the reagent is aspirated from the syringe needle 4a, it is moved to the position of the reaction container 2 where the reagent of the syringe 4 is dispensed, and then the aspirated reagent is moved to the syringe needle 4a
And into the reaction vessel 2.

When a solvent is dispensed and supplied to the reaction vessel 2, the solvent is introduced into the syringe 4 via the liquid sending line 9 from the solvent container 8 storing the solvent to be dispensed, and the syringe 4 is dispensed with the solvent. The target solvent is moved to the position of the reaction container 2, and the introduced solvent is injected into the reaction container 2 from the syringe needle 4a. Normally, as described above, the liquid is sucked at the position of the frequent reagent container 6 or the common reagent container 7 and the syringe 4 is moved so as to inject the liquid at the position of the reaction container 2. In the case of the apparatus, conversely, the liquid suction is performed at the position of the reaction container 2 and the syringe 4 is moved so that the liquid is injected at the position of the frequent reagent container 6 or the common reagent container 7. I have.

In the case of the reaction block 1 of the embodiment, FIG.
As shown in FIG. 3, a sheet-shaped common septum 10 covering the inlet of each reaction vessel 2 and a pressurized liquid-permeable filter 11 attached to each reaction vessel 2 so as to cover the inside of the bottom of the reaction vessel 2 And a drain 12 provided for each reaction vessel 2 so as to communicate with the bottom of the reaction vessel 2, and a pressurized gas (for example, a high-pressure inert gas) from a gas cylinder GB is provided on the injection port side of the reaction vessel 2. ) Is provided. Therefore, at the time of injecting a reagent or a solvent, the syringe needle 4 a penetrates through the common septum 10 and enters the inside of the reaction vessel 2. In addition, an appropriate amount of resin particles 14 for solid-phase reaction are charged into each reaction vessel 2, and an on-off valve 15 is provided at the end of the gas introduction line 13. When the pressurized gas is introduced into the valve, the on-off valve 15 is closed.

Further, the apparatus of the embodiment is provided with a vibrating section 16 for vibrating the reaction block 1 during the execution of the synthesis reaction to shake the resin particles 14 in each of the reaction vessels 2. A discharge tray 17 for discharging unnecessary substances generated in the container 2 and a collecting block 18 for collecting the synthetic compound obtained in each reaction container 2 by the synthesis reaction for each reaction container 2 are also provided below the reaction block 1. It is arranged movably between the side position and the standby position.

In the synthesis process in the automatic synthesizer of the embodiment, the solid phase reaction proceeds in the resin particles 14 of each reaction vessel 2 into which necessary reagents and solvents are dispensed and supplied, and the desired synthetic compound is obtained. can get. After completion of the synthesis reaction, the compound generated inside the resin particles 14 is extracted (acidic).
The chemical is sent from the inlet. When the compound is extracted, the pressurized gas of the gas cylinder GB is introduced from the gas introduction line 13, and the synthetic compound is allowed to pass through the pressurized liquid-permeation filter 11 together with the extraction chemical solution, and the collected block 1 is collected from the drain 12.
Flush to 8.

Next, the configuration of the control system of the embodiment will be described. In the case of the automatic synthesizing apparatus according to the embodiment, a video display monitor 19 for displaying various screens necessary for operating the apparatus and a control unit 20 for executing various controls necessary for operating the apparatus in a timely manner are provided. In addition to being provided with an input operation device such as a keyboard (operation console) 21 and a mouse (pointing device) 22 for input operation, functions such as liquid chromatography and mass spectrometry are performed based on a synthesis protocol described later. And a characteristic configuration for generating an analysis schedule composed of input information for analyzing a synthetic compound with the analysis device. Hereinafter, this characteristic configuration will be specifically described mainly.

The control section 20 of the embodiment apparatus includes a screen display section 23 for displaying the screen necessary for the operation of the apparatus and an image display monitor 19, and a synthesis protocol previously input and set by an input operation device such as a keyboard 21 and a mouse 22. Synthetic protocol storage unit 24 to be stored, and dispensing control for sending to the liquid dispensing unit 3 a command signal for executing the dispensing operation according to the dispensing procedure in the synthetic protocol stored in the synthetic protocol storage unit 24. A synthesizing protocol analyzing unit 26 for analyzing the synthesis protocol used for generating the synthetic compound and extracting input information for input to the analyzer from the synthesis protocol; and input information for inputting to the analyzer. An input information storage unit 27 that stores input information that is not included in the synthesis protocol; Input information and the input information storing section 27
And an analysis schedule generation unit 28 that generates an analysis schedule composed of input information to be input to the analysis device based on the input information read from the analysis device.

The screen display unit 23 includes a synthesis protocol setting screen for the operator to set a synthesis protocol, an analysis method setting screen for setting an analysis method in the analyzer, and a protocol analysis for displaying the analysis contents of the synthesis protocol. Screens,
Various screens such as a wizard-type screen for inputting input information necessary for the analyzer are appropriately displayed.

The synthesis protocol storage unit 24 stores the synthesis protocol set by using the keyboard 21 and the mouse 22 in accordance with the synthesis protocol setting screen displayed on the video display monitor 19. In this synthesis protocol, steps to be performed when performing a plurality of types of synthesis reactions, an execution order of each step, detailed procedures of each step, and the like are set. For example, these steps include a dispensing step of dispensing a predetermined chemical solution into a predetermined reaction vessel 2, a stirring step of shaking the reaction rack 1 to stir the inside of the reaction vessel 2, a inside of the reaction vessel 2 and the inside of the syringe 4, and the like. Draining step of draining the solution of the above, a purging step of purging the solution in the syringe 4, a container cleaning step of cleaning each container, a standby step of waiting the apparatus, a temperature adjusting step of raising or lowering the temperature of the reaction rack 1 and the like. There is a process of. For example, in the dispensing process, which set location (α,
(6, 7, 8) set at the position address of β, γ)
Therefore, the information on the amount of the reagent and the solvent to be dispensed is included in the position address of the set place (δ) of the reaction container 2. For example, in a certain dispensing step, 1 to 4 cc of the common reagent is set from the common reagent container 7 set in the setting place β (B, 5) of the common reagent container 7 and the setting place δ (B, 7) to While dispensing into the reaction vessel 2 set at (E, 7), the setting place γ of the solvent vessel 8 is set.
A procedure is set such that the solvent container 8 set in (C, 1) or the solvent is dispensed by 2 cc into the reaction container 2 set in the setting places δ (B, 7) to (E, 7). You.
In a certain stirring process, a procedure is set in which the electric motor is rotated at 900 rpm to shake the reaction rack 1 for one hour. Similarly, a control procedure of the apparatus corresponding to each of the other steps is set. As described above, a synthesis protocol is configured by setting parameters necessary for each of these steps.

The dispensing control section 25 transmits a command signal to the liquid dispensing section 3 according to the dispensing step included in the synthesis protocol. Also, command signals corresponding to other steps included in the synthesis protocol are sent to the corresponding mechanism on the reaction system side. Then, by executing each step included in the synthesis protocol, a synthetic compound corresponding to each condition is generated in each reaction vessel 2.

The synthesis protocol analysis unit 26 reads out the synthesis protocol stored in the synthesis protocol storage unit 24 and used at the time of generation of the synthetic compound to be analyzed by the analysis device, and converts the synthesis protocol into an input to the analysis device. It retrieves the included input information.

The input information storage section 27 stores the image display monitor 1
An analysis method setting screen for setting the analysis method with the analyzer displayed in 9, a protocol analysis screen for displaying the analysis contents of the synthesis protocol, and a wizard-type input screen for setting input information required for the analyzer And input information such as information on initial values of various parameters stored in advance according to the analyzer, and information set using the keyboard 21 and the mouse 22 according to the above.

The analysis schedule generation unit 28 performs a process based on the input information extracted by the synthesis protocol analysis unit 26 and the input information stored in the input information storage unit 27.
This is to generate a table-type analysis schedule to be input to the analyzer. This analysis schedule
This is data in the form of a table in which input information such as a sample name, a file name storing an analysis method, and a file name of a storage destination of an analysis result is set for each synthetic compound. In addition,
The input information extracted by the combining protocol analysis unit 26 corresponds to the first input information in the present invention, and the input information read from the input information storage unit 27 corresponds to the second input information in the present invention.

The configuration of the control system of the above-described apparatus is built around a personal computer and software (computer program). The synthesis protocol storage unit 24 and the input information storage unit 27 in the control unit 20 are configured by storage devices such as a RAM and a ROM, and include a screen display unit 23, a dispensing control unit 25, a synthesis protocol analysis unit 26, The processing control unit such as the schedule generation unit 28 is configured by a CPU that executes a program for performing the processing. The keyboard 21 or the mouse 22 corresponds to an input unit or an instruction unit in the present invention. The synthesis protocol analysis unit 26 corresponds to the synthesis protocol analysis unit in the present invention, the input information storage unit 27 corresponds to the input information storage unit in the present invention, and the analysis schedule generation unit 28 corresponds to the analysis schedule generation unit in the present invention.

Next, the processing of the characteristic portion of the present invention in the embodiment apparatus having the above configuration will be described with reference to the flowchart shown in FIG.

Step S1 (Display of Protocol Analysis Screen) The operator operates the keyboard 21 and mouse 22 to
Is displayed on the video display monitor 19 as shown in FIG. The protocol analysis screen 60 includes a matrix display area 61 having a form corresponding to each reaction vessel 2 of the reaction block 1, a synthesis protocol used for a predetermined reaction vessel 2, a generated analysis schedule, and an analysis result. And the like, and a tag display area 62 in which each tag is displayed. Hereinafter, the tag display area 6
2 is called a synthesis protocol display area 63 and a case where an analysis schedule is displayed in the tag display area 62 is called an analysis schedule display area 64.

Step S2 (set the range of generation of the analysis schedule) In order to analyze the synthetic compound generated in any of the reaction vessels 2 of the reaction block 1, the operator selects a matrix corresponding to the arbitrary reaction vessel 2. An area on the display area 61 is designated by the keyboard 21 or the mouse 22. Thereby, the generation range of the analysis schedule for analyzing the synthetic compound generated in the reaction vessel 2 corresponding to the region can be set. Specifically, a mouse cursor (not shown) is operated by the keyboard 21 or the mouse 22, and the mouse cursor points to an area surrounded by, for example, (B, 7) to (E, 10) on the matrix display area 61. When an area corresponding to an arbitrary reaction container 2 is designated in this way, the protocol analysis unit 26 reads the synthesis protocol used for the arbitrary reaction container 2 from the synthesis protocol storage unit 24, and stores the synthesis protocol. It is displayed in the synthesis protocol display area 63. If the entire matrix display area 61 is indicated, the entire synthesis protocol is displayed, and if a single reaction vessel 2 is selected,
The synthesis protocol used for the reaction vessel 2 is displayed. Step S2 corresponds to the function of the instruction means in the present invention.

Step S3 (setting the input information of the analyzer) In order to input the input information of the analyzer that cannot be extracted from the above-described synthesis protocol, the operator displays a schedule creation wizard screen 70 as shown in FIG. Display. On this schedule creation wizard screen 70, a storage file name in which the analysis method is stored is set, LC (liquid chromatography) quantitative calculation, M
Data processing such as S (mass spectrometry) quantitative calculation is set. The schedule creation wizard screen 70 includes a plurality of types of screens (not shown).
In addition to the items shown in FIG. 7, these screens include a screen for setting a storage file name for storing a generated analysis schedule, a sample name of a synthetic compound, and the like. These screens are displayed on button 71 or button 72.
By clicking, it can be displayed arbitrarily.
After setting the input information of the necessary items, the operator clicks the completion button 73 on the schedule creation wizard screen 70. When the completion button 73 is clicked, the synthesis protocol analysis unit 26 stores the input information set on the schedule creation wizard screen 70 into the input information storage unit 27.
Once. Step S3 corresponds to the function of the input means in the present invention.

Step S4 (Synthesis Protocol Analysis) When the above-mentioned completion button 73 is clicked, furthermore,
The synthesis protocol analysis unit 26 displays the matrix display area 6
The synthesis protocol of each reaction vessel 2 corresponding to the area designated by 1 is analyzed, and input information necessary for creating an analysis schedule is extracted. The input information extracted from the synthesis protocol is, for example, information such as the number of synthetic compounds to be analyzed. Step S4 corresponds to the function of the synthesis protocol analysis means in the present invention.

Step S5 (Generation of Analysis Schedule) After the analysis by the synthesis protocol analysis unit 26 is completed, the analysis schedule generation unit 28
Based on the input information stored in the input information storage unit 27, an analysis schedule in a table format is generated. As shown in the analysis schedule display area 64 shown in FIG. 8, the analysis schedule has a number of rows corresponding to, for example, 16 such as the number of synthetic compounds, which is input information extracted from the synthesis protocol. , Table format data in which the row direction is the number of columns for other input information to be input to the analyzer. Step S5
Corresponds to the function of the analysis schedule generation means in the present invention.

Specifically, the analysis schedule generation unit 28
Corresponds to the first synthetic compound to be analyzed, and stores various kinds of input information such as the sample name, analysis method file, dilution ratio, and analysis result storage file name stored in the input information storage unit 27. Write in the row direction. Further, various input information such as a sample name, a file of an analysis method, a dilution ratio, and a file name of a storage file of an analysis result are associated with a second synthetic compound in a line below the first input information. Is written in the row direction. Similarly, the input schedule is sequentially written in the row direction for each synthetic compound to be analyzed while sequentially changing the row, thereby generating a table format analysis schedule.
When the generation of the analysis schedules for all the synthetic compounds is completed, the analysis schedule generation unit 28 stores the analysis schedules in a file with a predetermined file name and displays the analysis schedules in the analysis schedule display area 64. Step S5 ends. Although FIG. 8 shows a case where the input information in the column direction has the same value, the present invention is not limited to this, and each input information in the column direction may have a different value.

The analysis schedule generated in steps S1 to S5 is read by an analyzer connected through a network or the like, for example. The analyzer analyzes each synthesized compound according to the read analysis schedule.

As described in detail above, according to the automatic synthesis apparatus of the embodiment, the input information included in the synthesis protocol used when generating the synthetic compound, the input information stored in the input information storage unit 27, Since the analysis schedule in the form of a table is generated on the basis of the above, a series of processes from synthesis to analysis is compared with a conventional case where an operator manually inputs each input information on the analyzer side for each synthetic compound. Processing can be performed efficiently. Further, since the schedule creation wizard screen 70 is used when setting the input information, the number of input information to be set can be reduced, and an input error can be prevented.

The present invention is not limited to the above embodiment, but can be modified as follows. (1) In the above-described embodiment, each screen in the mode shown in FIGS. 6 to 8 is used. However, the present invention is not limited to this. For example, the matrix display area 61 and the tag display area 62 are separated from each other. It can be configured to be displayed in a window.

(2) In the above-described embodiment, the case where the analysis schedule is generated after the synthetic compound is generated has been described. However, the present invention is not limited to this. For example, the analysis schedule is used before the synthetic compound is generated. An analysis schedule can be generated in advance by using a synthesis protocol to be performed.

(3) In the automatic synthesizing apparatus according to the above-described embodiment, the number of reaction systems is one. However, an apparatus having a configuration in which two identical reaction systems controlled by one control system are provided. , As a modification.

(4) Example The apparatus was an organic automatic synthesizer, and a compound was synthesized by a solid phase reaction. However, the apparatus of the present invention may be an inorganic automatic synthesizer, An apparatus having a configuration in which a compound is synthesized by a liquid phase reaction may be used.

[0045]

As apparent from the above description, the present invention has the following effects. That is, according to the first aspect of the present invention, the analysis schedule is calculated based on the first input information obtained by analyzing the synthesis protocol and the second input information stored in the input information storage means. Is generated, a series of processes from generation of a synthetic compound to analysis can be efficiently performed. Further, since the first input information is extracted from the synthesis protocol used at the time of generating the synthetic compound, an input error of the first input information can be eliminated.

According to the second aspect of the present invention, since the second input information is input by the input means, it is possible to correspond to various input information to be input to the analyzer.

According to the third aspect of the present invention, an analysis schedule is generated for a synthetic compound generated in an arbitrary reaction vessel designated by the designation means.
Only synthetic compounds that require analysis can be analyzed. As a result, processing from synthesis to analysis can be performed more efficiently.

[Brief description of the drawings]

FIG. 1 is a block diagram illustrating an overall configuration of an automatic synthesis apparatus according to an embodiment.

FIG. 2 is a plan view showing a configuration of a reaction system of the apparatus of the embodiment.

FIG. 3 is a schematic diagram showing a configuration of a main part of a reaction block of the apparatus of the embodiment.

FIG. 4 is a diagram showing a position address of a setting place of each container.

FIG. 5 is a flowchart when an analysis schedule is generated.

FIG. 6 is a diagram showing a protocol analysis screen.

FIG. 7 is a diagram showing a schedule creation wizard screen.

FIG. 8 is a diagram showing a state in which an analysis schedule is displayed on a protocol analysis screen.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 ... Reaction block 2 ... Reaction container 3 ... Liquid dispensing part 19 ... Video display monitor 21 ... Keyboard 22 ... Mouse 23 ... Screen display part 24 ... Synthetic protocol storage part 25 ... Dispensing control part 26 ... Synthetic protocol analyzing part 27 … Input information storage unit 28… analysis schedule generation unit

Claims (3)

[Claims] 1. A reaction block in which a plurality of reaction vessels for performing a synthesis reaction are arranged, a dispensing means for dispensing a reaction solution into each reaction vessel of the reaction block, and a synthesis reaction in the reaction vessel. A synthesis protocol storing means for storing a synthesis protocol for performing, by dispensing a plurality of types of reaction liquids into the reaction container and performing synthesis based on the synthesis protocol, thereby synthesizing in the reaction container. In an automatic synthesizer for generating a compound, first input information to be input to an analyzer for analyzing the generated synthetic compound by analyzing a synthesis protocol used for generating the synthetic compound in the reaction vessel. From the synthesis protocol, and second input information that is input to the analyzer and is not included in the synthesis protocol. Based on the input information storage means, the first input information extracted from the synthesis protocol, and the second input information read from the input information storage means, for analyzing the synthetic compound by the analyzer. An automatic synthesizing apparatus, comprising: an analysis schedule generating means for generating an analysis schedule. 2. The automatic synthesizing apparatus according to claim 1, further comprising: input means for inputting said second input information, wherein said input information storage means stores said second input means input by said input means. Automatic synthesizer. 3. The automatic synthesizing apparatus according to claim 1, further comprising an instruction unit for instructing an arbitrary reaction container in the reaction block, wherein the synthesis protocol analyzing unit is configured to generate the information in the arbitrary reaction container. First input information for analyzing the synthesized compound thus obtained is extracted from the synthesis protocol;
An automatic synthesis apparatus for generating an analysis schedule for analyzing a synthetic compound generated in an arbitrary reaction vessel designated by the indicating means, based on the input information of the second and the second input information.