JO984B1 - K-clavulanate/tri hydrate formulations - Google Patents

K-clavulanate/tri hydrate formulations

Info

Publication number
JO984B1
JO984B1 JO1977984A JOP19770984A JO984B1 JO 984 B1 JO984 B1 JO 984B1 JO 1977984 A JO1977984 A JO 1977984A JO P19770984 A JOP19770984 A JO P19770984A JO 984 B1 JO984 B1 JO 984B1
Authority
JO
Jordan
Prior art keywords
clavulanate
tri hydrate
amoxicillin trihydrate
hydrate formulations
potassium
Prior art date
Application number
JO1977984A
Other languages
Arabic (ar)
Inventor
جون كراولي باتريك
Original Assignee
بيتشام غروب ليمتد
جون كراولي باتريك
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10423254&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JO984(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by بيتشام غروب ليمتد, جون كراولي باتريك filed Critical بيتشام غروب ليمتد
Application granted granted Critical
Publication of JO984B1 publication Critical patent/JO984B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A dry unit- dose pharmaceutical composition suitable for oral administration which composition comprises 20mg to 1500 mg of amoxicillin trihydrate, 20 mg to 500 mg of potassium clavulante and a pharmaceutically acceptable carrier with the proviso that the weight ratio of amoxicillin trihydrate to potassium clavulanate is from 6:1 to 1:1, has favoured storage properties ,such composition are presented in enclosed containers which they also contain a desiccant
JO1977984A 1977-10-11 1977-10-11 K-clavulanate/tri hydrate formulations JO984B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4219177 1977-10-11

Publications (1)

Publication Number Publication Date
JO984B1 true JO984B1 (en) 1979-12-01

Family

ID=10423254

Family Applications (1)

Application Number Title Priority Date Filing Date
JO1977984A JO984B1 (en) 1977-10-11 1977-10-11 K-clavulanate/tri hydrate formulations

Country Status (24)

Country Link
US (2) US4441609A (en)
JP (1) JPS5476831A (en)
AU (1) AU525089B2 (en)
BE (1) BE870988A (en)
CA (1) CA1105385A (en)
CH (1) CH642258A5 (en)
DE (1) DE2843318A1 (en)
FR (1) FR2405711A1 (en)
GB (1) GB2005538B (en)
HK (1) HK73785A (en)
IE (1) IE47450B1 (en)
IL (1) IL55660A (en)
IT (1) IT1109273B (en)
JO (1) JO984B1 (en)
KE (1) KE3525A (en)
MT (1) MTP836B (en)
MY (1) MY8500996A (en)
NL (1) NL190631B (en)
NZ (1) NZ188497A (en)
PL (1) PL210174A1 (en)
PT (1) PT68600A (en)
SE (2) SE435899B (en)
SG (1) SG34985G (en)
ZA (1) ZA785682B (en)

Families Citing this family (58)

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IE41109B1 (en) * 1974-04-20 1979-10-24 Beecham Group Ltd Novel -lactam antibiotic from streptomyces clavuligerus
SE421796B (en) * 1975-02-07 1982-02-01 Glaxo Lab Ltd PROCEDURE FOR PURIFICATION OF CLAVULANIC ACID AND ITS SALTS
DE2964817D1 (en) * 1978-09-06 1983-03-24 Beecham Group Plc Pharmaceutical compositions containing two beta-lactam derivatives
GR70283B (en) 1979-10-02 1982-09-03 Beecham Group Ltd
NZ198241A (en) * 1980-09-27 1983-12-16 Beecham Group Ltd Tablet containing amoxycillin and potassium clavulanate
US4406887A (en) * 1981-10-13 1983-09-27 Bristol-Myers Company Method for treating resistant bacteria including anaerobes
EP0080862B1 (en) * 1981-12-02 1985-09-25 Beecham Group Plc Pharmaceutical formulation comprising beta-lactam antibiotics
US5743398A (en) * 1984-05-22 1998-04-28 Southpac Trust International, Inc. Floral wrapper utilizing a breathable packaging material
FR2593152B1 (en) * 1986-01-22 1988-12-23 Adir WATERPROOF PACKAGING IN THE FORM OF ALVEOLAR PLATES ALLOWING FOR GAS EXCHANGES BETWEEN THE ALVEOLES.
EP0273209B1 (en) * 1986-12-30 1992-01-15 American Cyanamid Company Composition of matter containing polycarbophil
GB9007143D0 (en) * 1990-03-30 1990-05-30 Beecham Group Plc Veterinary composition
US5814337A (en) * 1992-10-07 1998-09-29 Beecham Group Plc Pharmaceutical formulation
GB9009446D0 (en) * 1990-04-26 1990-06-20 Beecham Group Plc Veterinary composition
US5643902A (en) * 1990-04-26 1997-07-01 Pfizer Inc. Veterinary treatment
US5861172A (en) * 1991-05-08 1999-01-19 Laboratorios Beecham Sa Pharmaceutical formulations of compacted granulates of β-lactam antibiotics
GB9109862D0 (en) * 1991-05-08 1991-07-03 Beecham Lab Sa Pharmaceutical formulations
GB9201639D0 (en) * 1992-01-25 1992-03-11 Smithkline Beecham Plc Pharmaceutical formulations
GB9408117D0 (en) * 1994-04-23 1994-06-15 Smithkline Beecham Corp Pharmaceutical formulations
GB9411626D0 (en) * 1994-06-10 1994-08-03 Smithkline Beecham Plc Package
CN1075022C (en) * 1994-08-05 2001-11-21 康沃尔西药服务有限公司 Container for moisture-sensitive material
GB9416599D0 (en) * 1994-08-17 1994-10-12 Smithkline Beecham Plc Pharmaceutical formulation
DZ2028A1 (en) 1995-05-03 2002-10-23 Smithkline Beecham Plc Medicines used to treat bacterial infections in pediatrics.
US20030109503A1 (en) * 1995-06-06 2003-06-12 Smithkline Beecham P.L.C. Pharmaceutical formulations comprising clavulanic acid alone or in combination with other beta-lactam antibiotics
NZ318282A (en) 1995-09-07 2000-01-28 Smithkline Beecham Corp Pharmaceutical formulation containing amoxycillin and clavulanate in a weight ratio of 12:1 and 20:1
AT403375B (en) * 1995-11-15 1998-01-26 Biochemie Gmbh METHOD FOR FILLING ALKALINE SALTS OF CLAVULANIC ACID
ITMI952354A1 (en) * 1995-11-16 1997-05-16 Smithkline Beecham Spa PHARMACEUTICAL COMPOSITION
AT407701B (en) * 1996-08-12 2001-05-25 Biochemie Gmbh Mixture which is suitable for direct tableting and contains as essential components amoxicillin trihydrate and the calcium salt of clavulanic acid, and process for preparing this mixture
AT407214B (en) * 1996-03-13 2001-01-25 Biochemie Gmbh Process for the preparation of excipient-free agglomerates of beta-lactam antibiotics
TWI225402B (en) 1996-03-13 2004-12-21 Biochemie Gmbh Auxiliary-free agglomerates
US6112888A (en) * 1996-06-28 2000-09-05 W. R. Grace & Co.-Conn. Non-reclosable packages containing desiccant matrix
US6180708B1 (en) 1996-06-28 2001-01-30 W. R. Grace & Co.-Conn. Thermoplastic adsorbent compositions containing wax and insulating glass units containing such compositions
GB9616536D0 (en) * 1996-08-06 1996-09-25 Quadrant Holdings Cambridge Co-amoxiclav dosage form
US8022095B2 (en) 1996-08-16 2011-09-20 Pozen, Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
EP0975342B1 (en) * 1997-02-14 2003-06-25 Laboratoire GlaxoSmithKline S.A.S. Pharmaceutical formulations comprising amoxocyllin and clavulanate
US20030124187A1 (en) * 1997-02-14 2003-07-03 Smithkline Beecham Laboratoires Pharmaceutiques, Pharmaceutical formulations comprising amoxycillin and clavulanate
WO2000025751A2 (en) * 1998-10-30 2000-05-11 Fuisz International Ltd. Improved amoxycillin and clavulanate composition
US6177421B1 (en) 1999-05-04 2001-01-23 Fuisz International Ltd. Amoxicillin and clavulanate composition
IE990159A1 (en) * 1999-02-26 2000-09-20 Fuisz Internat Ltd Storage Stable Amoxycillin and Clavulanate Suspension Composition.
US7250176B1 (en) * 1999-04-13 2007-07-31 Beecham Pharmaceuticals (Pte) Limited Method of treating a bacterial infection
US6878386B1 (en) 1999-04-13 2005-04-12 Beecham Pharmaceuticals (Pte) Limited Method of treating a bacterial infection comprising amoxycillin and potassium clavulanate
US6294199B1 (en) * 1999-04-13 2001-09-25 Beecham Pharmaceuticals (Pte) Limited Method of treating a bacterial infection comprising administering amoxycillin
CA2746824A1 (en) * 1999-08-16 2001-01-22 Revaax Pharmaceuticals, Llc Neurotherapeutic composition and method
US6426342B2 (en) * 1999-08-16 2002-07-30 Revaax Pharmaceuticals, Llc Use of β-lactamase inhibitors as neuroprotectants
SI20411A (en) * 1999-12-22 2001-06-30 LEK, tovarna farmacevtskih in kemičnih izdelkov, d.d. Watersoluble powders for peroral solution and their use
US6905016B2 (en) * 2000-03-14 2005-06-14 Noven Pharmaceuticals, Inc. Packaging system for transdermal drug delivery systems
AT412213B (en) * 2000-05-30 2004-11-25 Sandoz Ag METHOD FOR DRYING AMOXICILLIN OR AMOXICILLIN-CONTAINING, ORAL, SOLID PHARMACEUTICAL COMPOSITIONS USING A GAS WITH A DEFINED GAS HUMIDITY
EP1330236A2 (en) 2000-10-12 2003-07-30 Beecham Pharmaceuticals (Pte) Limited Formulation containing amoxicillin
US6756057B2 (en) 2000-10-12 2004-06-29 Beecham Pharmaceuticals (Pte) Limited Amoxicillin and potassium clavulanate dosage form
JPWO2004016262A1 (en) * 2002-08-12 2005-12-02 協和醗酵工業株式会社 Amino acid-containing chewable tablets
US7341742B2 (en) * 2002-09-30 2008-03-11 L. Perrigo Company Simethicone containing tablet composition and method
MY147756A (en) * 2005-05-25 2013-01-15 Theravance Inc Benzimidazole-carboxamide compounds as 5-ht4 receptor agonists
DE102006007830A1 (en) * 2006-02-17 2007-08-30 Grünenthal GmbH Storage-stable oral dosage form of amoxicillin and clavulanic acid
CN101970111B (en) 2007-06-21 2013-09-11 简·探针公司 Instrument and receptacles for performing processes
AU2008317315A1 (en) * 2007-10-26 2009-04-30 Rexahn Pharmaceuticals, Inc. Pharmaceutical formulation of clavulanic acid
WO2010127125A1 (en) * 2009-04-29 2010-11-04 Rexahn Pharmaceuticals, Inc. Clavulanate formulation for neuroprotection and treatment of neurodegenerative disorders
TR200909787A2 (en) 2009-12-25 2011-07-21 Bi̇lgi̇ç Mahmut Pharmaceutical formulations containing a third generation cephalosporin and clavulanic acid.
US8652527B1 (en) 2013-03-13 2014-02-18 Upsher-Smith Laboratories, Inc Extended-release topiramate capsules
US9101545B2 (en) * 2013-03-15 2015-08-11 Upsher-Smith Laboratories, Inc. Extended-release topiramate capsules

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3128135A (en) * 1962-05-29 1964-04-07 Anaconda Wire & Cable Co Moisture-free package
US3567085A (en) * 1968-12-02 1971-03-02 James G Flores Neck-supported pill container
IE41109B1 (en) * 1974-04-20 1979-10-24 Beecham Group Ltd Novel -lactam antibiotic from streptomyces clavuligerus

Also Published As

Publication number Publication date
ZA785682B (en) 1979-09-26
SE451668B (en) 1987-10-26
AU525089B2 (en) 1982-10-21
MY8500996A (en) 1985-12-31
JPS6341886B2 (en) 1988-08-19
GB2005538B (en) 1982-05-26
NZ188497A (en) 1981-05-01
PL210174A1 (en) 1980-08-11
IT7851415A0 (en) 1978-10-09
US4301149A (en) 1981-11-17
NL190631B (en) 1994-01-03
MTP836B (en) 1979-05-11
SG34985G (en) 1985-11-15
BE870988A (en) 1979-04-03
AU4050678A (en) 1980-04-17
SE7810591L (en) 1979-04-11
JPS5476831A (en) 1979-06-19
IT1109273B (en) 1985-12-16
KE3525A (en) 1985-05-31
CA1105385A (en) 1981-07-21
SE8107592L (en) 1981-12-17
IL55660A (en) 1981-09-13
PT68600A (en) 1978-10-01
HK73785A (en) 1985-10-04
IE782019L (en) 1979-04-11
DE2843318A1 (en) 1979-04-12
IE47450B1 (en) 1984-03-21
NL7810176A (en) 1979-04-17
GB2005538A (en) 1979-04-25
US4441609A (en) 1984-04-10
CH642258A5 (en) 1984-04-13
FR2405711A1 (en) 1979-05-11
FR2405711B1 (en) 1982-10-29
IL55660A0 (en) 1978-12-17
SE435899B (en) 1984-10-29

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