IT202000017212A1 - EQUIPMENT FOR THE MEASUREMENT OF PHYSIOLOGICAL PARAMETERS. - Google Patents

Description

TITLE

Equipment for measuring physiological parameters.

DESCRIPTION

The present invention ? relating to an apparatus for measuring physiological parameters. In particular, the present invention aims to provide an instrument capable of measuring pre-established physiological values to determine, through their combined evaluation and comparison with reference values, the general state of health of an individual as a whole, i.e. for obtain a general value that takes into account the interactions between the peripheral autonomic and somatic nervous systems.

The description of the apparatus object of the invention will be preceded by an introduction relating to the scientific approach to the subject in order to better understand the setting which underlies the innovative concept of the invention and, consequently, the functioning of the apparatus.

How will it turn out? with more evidence from this description, ? It is possible to affirm that the equipment in question constitutes an innovative equipment able to evaluate in an objective and regular way, synchronizing them, the autonomic peripheral nervous system the somatic peripheral nervous system, comparing the results obtained with the general state of health, evidenced by the measurement of the epigenetic damage possibly present on the whole complex system of the ?man machine?.

? It is necessary to take into account that the nervous system has the task of simulating the environment through the data it receives both from inside and outside the body (surrounding environment). These data? are understood in the form of energy, emitted and received in mode? complex and non-linear.

This equipment is based on the concepts of quantum physics, already? widely used in medical diagnostics, for example in magnetic resonance, exploiting parameters such as, for example, magnetic fields, oscillations, frequencies, rhythms.

? It is known that our body emits electric fields thanks to the action potential of each single neuron, which emits energy thanks to the change of charge between the inside and the outside of the cell membrane. This electric field involves the activation of a coordinated magnetic field, as visible in the graph of Fig. 2.

The magnetic field can be measured according to the oscillation frequencies it generates; can therefore be defined as ?rhythms? oscillators. Our body has central rhythm generators located centrally, in the bulb of the CNS (medulla oblongata) and in the spinal cord. A central rhythm generator assumes the existence of a neural network potentially capable of self-generating a periodic stimulus since it? endowed with capacity oscillatory.

At the encephalic level, at least three oscillators relating, respectively, to walking, breathing and chewing can be considered.

From the analysis of the experimental data one can to assume that the locomotor movements originate from a central rhythmic generator placed at the mesencephalic level (mesencephalic locomotor region), acting on other hierarchically dependent nuclear structures at the spinal level, equipped with an activity? of the oscillating type necessary for the production of the movement. This generator is in turn controlled by a sub-thalamic locomotion structure capable of modulating its oscillations.

The subthalamic locomotor region receives information from the pale and premotor cortex and is connected in output with the midbrain locomotor region in terms of facilitators and with the substantia nigra in terms of inhibitory type.

This central generator would come into action at the beginning of the locomotor act producing the beginning of walking.

The midbrain locomotor region (also called Central Rhythm Generator or GCR in the present description) includes the cuneiform nucleus, the locus coeruleus, the substantia nigra and the median nuclei of the rate and has numerous efferent pathways: the one of greatest importance for locomotion? represented by the ventrolateral funiculus (ventrolateral reticulospinal tract, lateral vestibulospinal tract, ceruleospinal tract). Most of the GCRs provide for the existence of interconnected centres.

In the GCR of locomotion there are centers capable of generating the flexion phase, and others that are capable of inducing the extensor phase of the gait. The outgoing rhythmic signals do not seem to reach the motoneurons directly, but, to produce the step, pre-motoneuron integration stations connected both with the GCR of gait and with the encephalic systems responsible for the control of voluntary movement are probably used. with plurimetameric and monometameric reflex arcs. In this case, the afferent input is necessary only to select the times and characteristics of the locomotor pattern and to make the necessary adjustments to the rhythmic and self-generated executive program in the event of variations in the forces acting on the receptive system.

The central rhythmic generator of locomotion ? easily modifiable also by the signals coming from the cortical and striatal structures able to make more? intentional the pattern of the step that generally ? fully automated. The afferent signals coming from the periphery, even if they are not necessary to generate walking, perform accessory tasks, capable of adapting the locomotor system to the environment; this task ? made by:

? the facilitation of the locomotion nuclei (GCR) during the different gait phases; ? the modification of the excitability? and the excitation times of the locomotion nuclei (GCR);

? the enhancement of the inhibition of the nuclei already? inhibited as part of the activation of the oscillating system;

? coordination between functionally coupled motor nuclei;

? the modulation of the reflex systems according to the step phase;

? the realization of adaptive compensations to the environment through the exploitation of spinal and supraspinal reflex arcs (see influence of the vestibular nuclei);

? the sending of information to the cortical centers in charge of processing the exteroproprioceptive stimulus.

During walking, is there a marked activity? metabolic also at the cerebellar level and ? evident an increase in the frequency of discharge at the level of the dorsal and ventral spino-cerebellar and spino-reticulo-cerebellar tracts.

A large amount of ascending information is sent to the encephalic structures especially through the dorsal and ventral spi\no-cerebellar pathways.

In particular, the dorsal spino-cerebellar pathways would be able to send information on the activity of the muscles, while the ventral spino-cerebellar tract would be in a position to transmit information on the activity? of the locomotion program generator. One of the tasks of the cerebellum in gait control? that of regulating the step phase and modulating the coordination between the limbs. Also the basal nuclei and in particular the striatum, are involved in locomotor control, the ventral nucleus pallidus is involved in searching movements connected to memory and emotional situations, while the fibers coming from the caudate nucleus, when stimulated by the prefrontal cortex, activate oriental locomotives towards motivating elements.

Not quite defined yet? the role of the cerebral cortex in gait control; however, the anterior frontal cortex seems to play an inhibitory role with respect to walking, while the pyramidal cells of area 4 seem to control the length of the locomotor cycle by reducing the time of unipodalic stance.

The neurons that give rise to the cortico-rubro-spinal pathway, the cortico-reticulospinal and vestibulo-spinal pathways are in any case rhythmically excited during the different phases of locomotion so as the noradrenergic neurons of the locus coeruleus are particularly active.

The locomotor GCR, in addition to activating the alpha motor neurons connected with the gait pattern, simultaneously activates the gamma motor neurons related to these and the interneurons responsible for reciprocal and recurrent inhibition.

? It is therefore possible to say that walking is expressed through a coactivation of the alpha/gamma system so? to constantly leave the spindles in a state of receptivity. The coactivation of the alpha/gamma system? also present in other activities? rhythmic motor skills such as chewing and breathing.

Under conditions of alpha/gamma coactivation, maintaining spindle tension allows the nervous system to be receptive to changes in muscle tension and stretch throughout the gait cycle phase, thus to keep the flow of afferent proprioceptive information intact.

In particular, the peripheral proprioceptive afferents are not necessary for straight-line locomotion on flat ground, and they acquire significant in the processes of directional reversal of the gear, in the variation of the speed? and in the processes of adaptation to the land.

The presence of activities afferent, capable of influencing the locomotor GCR, in a certain phase of the gait cycle does not however mean that this should or can produce analogous responses in other and different phases of the gait cycle.

Particularly noticeable ? this phenomenon in the case of nociceptive stimuli, since? a nociceptive stimulus applied to the sole of the foot in the monopodalic stance phase does not produce the response in triple flexion, in order to avoid the subsequent fall, while the same stimulus applied to the swinging foot produces an immediate strengthening of the flexion attitude.

An?identical afferent discharge can? then be channeled into different reflex circuits depending on the stage in which it reaches the spinal cord.

The existence of a "central program" which regulates the rhythmic action of walking without the need for an afferent feed-back for its determinism has been confirmed by experiments. For example, in the spinal animal in which the pathway was interrupted afferent (such as the cut of the dorsal roots responsible for the innervation of the limbs), a normal motor output was observed at the motor neuron level.The recording of the bioelectrical activity of the muscles showed that, in addition to the alternating flexion-extensor activation, the appropriateness of muscle activity.In animals in which only the spinal cord was connected to the limbs, it was possible to make them walk on a mobile platform with a speed that depended exclusively on the movement of the platform itself: the central program was located in the spinal cord spinal.

Even if it has characteristics that allow the generation of motor patterns, locomotion, for its normal development, needs a continuous afferent feed-back.

The afferents are essential in the global program of locomotion and their anomaly leads to dysfunctions such as, for example, alteration of the ambulatory rhythm, which would be much more? slow, and changes in time course and motor pattern details.

In light of the new discoveries of neuroscience ? possible to say that our ? a ?brain that fires?, not a ?brain that thinks?. Continuous development, neuroplasticity, new neuronal connections, knowledge, cognition, are the result of a continuous drive in the environment. The innate ability of troubleshooting ? adopted only when the? man ? capable of moving in the environment, keeping the brain supplied with energy (about 25% of the total caloric consumption of the body) and therefore adapting to the stimuli and challenges that the environment continually poses. This ability? of adaptation of the human being, also related to higher mammals, determines the lifestyle.

For example, as exposed by S. W. Porges in ?The polyvagal theory?, unlike us, reptiles adopt a ?sit and wait? strategy. Their autonomic nervous system almost completely blocks the supply of energy, with the metabolism lowering, in a situation similar to that in which a snake awaits the victim. On the contrary, the human being, having a powerful heart divided into four chambers, can quietly adapt to the environment, with a constant supply of energy to the brain that can? continue in its business? knowledge, knowledge. Reptiles, on the contrary, not having much energetic power, do not put a vagal brake on the heart. Indeed, the dorsal vagus (or DMNX) takes over forcefully slowing down the vital rhythms, blocking movement, inhibiting and slowing down breathing to a minimum. On the contrary, the human being uses the vagal efference - myelinated vagus NA ? (ambiguous nucleus) as a sort of brake, to inhibit, manage, control the metabolic potential of this energy-intensive system.

The "high", active, reactive, vagal tone (or HF) allows mammals to remain calm in the environment, not to hyperventilate, not to lower CO2 levels too much, to keep the brain perfused with oxygen.

The human vagal tone (HF) works well, at best, while the individual is? in situations of tranquility, in the company of similar and family members, while sleeping, etc.; the same tone? on the other hand reduced when he has to face high level environmental stimuli, linked to survival, for example facing a predator, crossing a swollen river, running away from danger.

This is detected with the measurement of the variation of the heart rate or HRV (Hearth Reate Variability) and more? the frequency change? wide in the values of the oscillation, pi? ? positive and health index.

In relation to HRV measurement, it was once believed that the heartbeat at rest was monotonous and regular (for example, 60 beats per minute would result in one beat per second).

Subsequently, cardiological research has highlighted the existence of a difference in contraction times between one beat and another, in the order of a few milliseconds. This spontaneous change in heart rate seen to be correlated with the interactions pressor activity? respiratory and with the influences exerted by the branches of the sympathetic and parasympathetic nervous system on the cardiac muscle.

A healthy body, provided with a healthy cardiovascular system, will show surprising irregularity at rest. between heartbeats and a considerable variability? heart rate (HRV); conversely, an organism subject to chronic stress will have? a very regular heart rhythm with little variation.

In other words, the variability? heart rate (HRV) is an important index on the activity? of the autonomic nervous system.

As previously expressed, the purpose of the present invention ? that of providing a tool capable of measuring pre-established physiological values to determine, through their combined evaluation and comparison with reference values, the general state of health of an individual as a whole, or to obtain a general value that takes into account interactions between the peripheral autonomic and somatic nervous systems.

This result? obtained by means of an apparatus having the characteristics of claim 1. Other advantageous characteristics of the invention are the object of the dependent claims.

Among the advantages of the present invention the following can be listed: the apparatus allows to know in a substantially objective way the state of stress in which the examined individual is; the equipment manages in an innovative and original way to combine the data obtainable from a detection of HRV with the detection of a capnograph and inertial sensors, with the possibility? verification of the results obtained using other devices suitable for measuring the state of stress such as, for example, an adipometer, a bio-impedance meter, a hair bulb analyzer; with the results provided by the equipment? is it possible to size the quantity? and quality? workouts before cumulative psychophysiological effects occur, in the form of fatigue or decreased athletic performance; thanks to the data provided by the equipment? Is it possible to achieve a synchronization of the internal oscillatory systems, with consequent high physical and psychological benefits as it is? possible to optimize the functions of the respiratory, cardiovascular, hormonal and immune systems, as well as significant energy savings; ? It is possible to use the apparatus in question for the evaluation of the effects on the peripheral nervous system of particular pathologies, including neurological ones.

These and other advantages and features of the present invention will be more and better understood by any person skilled in the art from the following description and with the help of the annexed drawings, given as a practical exemplification of the invention, but not to be considered in a limiting sense, in which:

- Fig. 1 ? a diagram relating to a possible subdivision of the human nervous system;

- Fig. 2 ? a diagram showing the connection between an electric field (E) and a magnetic field (B);

- Fig. 3 ? a block diagram which represents a possible example of realization of an equipment made in conformity? of the present invention.

With reference to the attached drawings which only represent a scheme of possible embodiment of the invention, an apparatus (1) in accordance with of the found? usable for measuring physiological parameters of an individual. In particular, as expressed previously, the equipment (1) ? usable to determine, through the combination of measured values and comparison of these values with reference values, the general state of health of an individual as a whole, or to obtain a general value that also takes into account the interactions between the peripheral nervous system autonomic and somatic.

In Fig.1, the peripheral autonomic nervous system ? schematically identified by the dotted circle (I) and the somatic one by the circle (II).

The equipment includes:

- a detector of the variability? heart rate (HRV) related to the individual being examined;

- a capnograph or capnometer (CAP) capable of detecting a CO2 value of the individual being examined;

- a unit? central (UC) connected in input to said detector of the variability? of the heart beat frequency (HRV) and to said capnograph (CAP) and equipped with a software (ALG) able to supply in output a value (V1, V2, V3, V4) corresponding to the combined evaluation of the data received in input.

The equipment (1) can? be advantageously provided with an isoinertial sensor (SEN) connected to the input of said unit? central and including a motion sensor that can be positioned at the height of the lumbar area of the individual being examined.

The isoinertial sensor (SEN) ? provided with a band or other device for fixing to the human body so as to allow its association and detection in correspondence with the lumbar area, preferably in correspondence with the L3 vertebra. The sensor (SEN) ? a movement sensor and supplies data relating to a frequency, for example via the Fourier transform; in practice it provides a time-dependent function in the frequency domain.

The isoinertial sensor (SEN) in addition to the motion sensor that can be positioned at the height of the lumbar area can? include one or more static sensors placed, for example, at the neck or hips.

In fig. 3, with the reference (2) the detecting devices just described are indicated. ? is it possible to say that the data received from said detector of the variability? of the heart beat frequency (HRV) and by said capnograph (CAP) are used for evaluations relating to the autonomic nervous system (I) so as to define a cardiopulmonary oscillator and the data received from said isoinertial sensor (SEN) are used for evaluations relating to the somatic nervous system (II) so as to define a kinesthetic oscillator.

In addition to the devices indicated with (2), the equipment can? advantageously comprising at least one of the devices of the group comprising:

- an adipometer (ADI),

- a bioimpedance meter (BIA) e

- a hair bulb analyzer (SDR).

The adipometer (ADI) ? an instrument suitable for measuring the person's fat and ? constituted by an ultrasound-type probe capable of supplying information relating to the fat present which, in addition to nutrition, can be determined by hormonal causes or stressful situations.

The bioimpedance meter (BIA) can? be constituted by an instrument which, based on the presence of intercellular water, supplies a value relative to the impedance of the body. The hair bulb analyzer (SDR) can? be of the type known by the designation ?S-DRIVE? and able to provide information on the state of the individual in question. The S-Drive device uses an oscillating coil and works by converting natural wave frequencies (called ?signatures?) from hair samples into a digital file that is sent to an information center where a computer, using an algorithm, decrypts, encodes and digitizes the signature wave emanating from its resonance with the hair follicle and then reads it. The process ? relevant to the acquired epigenetic data. Relevance data can be used to create graphs and reporting tables.

The test makes it possible to evaluate the conditions in which the organism is in relation to the main environmental components to which we are constantly subjected, in excess or in deficiency, both with the diet and with the environment that surrounds us. It therefore allows us to adjust our needs in relation to what? that we come in contact with.

At the data level, the software (ALG) capable of processing the data received at the entrance from the unit? central (CU) ? set to consider the following detections in the standard: - for the detector of the variability? of heart rate (HRV): VLF value of about 23 (? 5)%, LF value of about 25 (? 5)%, HF value of about 51 (? 5)%, with a value of rMSSD between 40 (? 5) and 60 (? 5);

- for the capnograph (CAP) a value of mmHg CO2 ? 36 mmHg.

The variability detector? heart rate (HRV) ? connected to the individual being examined preferably by means of electrodes.

Furthermore, the capnographer (CAP) ? connected to the individual under examination preferably via nostril tubes, while the values of the adipometer (ADI) and/or bioimpedance meter (BIA) are preferably provided in image format.

? is it possible to say that the data received from the detector of the variability? of the heart rate (HRV) and the capnograph (CAP) are used for evaluations related to the autonomic nervous system (I) in order to define a cardiopulmonary oscillator and the data received from the isoinertial sensor (SEN) are used for evaluations related to the somatic nervous system (II) so as to define a kinesthetic oscillator.

Other characteristics of the invention will be set out below with examples designed to make the advantages better understood.

The analysis of the variability? of heart rate (HRV) allows you to understand, in a short time (in the order of minutes), the state of activity? of the Autonomic Nervous System and know if there ? a hyper or hypo activity, not very functional, of one of the two branches and to intervene to restore the correct balance.

The data relating to the trend of cardiac dynamics make it possible to acquire a series of quantitative and qualitative information from which ? possible to understand the state of the Autonomic Nervous System. The different types of time domain and heart rate analyzes provide specific indicators with multiple valence.

For example, in the domain of time, the data best known and used by sportsmen and by those who must maintain high intellectual performance? the value of rMSSD (acronym of ?root Mean Square of the Successive Differences?, or root mean square of the successive differences) which shows the measure of the activity? of the parasympathetic system in a specific period of time. A low rMSSD value? indication of a lack of activity? parasympathetic and difficulty in recovery from physical exertion or a situation of high emotional stress.

In the frequency domain, the data of greatest interest? the one relating to the 3 cardiac oscillation zones, each of which reflects specific activities? of the Autonomic Nervous System:

- Very Low Frequency band - VLF, includes the oscillations between 0.0033 and 0.03 Hz, represents the most? slow heart rate and ? directly related to the activities of body thermoregulation and the hormonal cycle;

- Low Frequency band - LF, includes oscillations between 0.03 and 0.15 Hz, represents slow changes in the heart rate and ? an index of activity? sympathetic, and the effectiveness of the baroreceptor loop, between the cardiovascular and respiratory systems, in the Hz range;

- High Frequency band - HF, includes the oscillations between 0.15 and 0.40 Hz, represents the changes more? fast due to the activity? parasympathetic.

? It has been shown that periods of chronic stress generate an increase in heart rates in the low frequency range with a loss of activity. in the high one, reflecting the natural increase of the activity? of the sympathetic system at the expense of the parasympathetic one.

The knowledge, by a sportsman or an individual in general, of this data can give a great advantage to size the quantity? and quality? of workouts before cumulative psychophysiological effects occur, in the form of fatigue or decreased athletic performance.

In the overall analysis of an individual's state of health and stress, it is necessary to take into account the fact that emotion, as a response to an environmental stimulus, is nothing else? what energy, which in the form of an activation potential lodges and traps both in the mind and in the body, creating ?trauma?.

Returning to the definition of Peter A. Levine (see Peter A. Levine? Somatic Experience?), the trauma is nothing else? that blocked energy, isn't it? what happens, but what we hold back in the absence of an empathic witness.

For this reason, the in-depth knowledge of the principles and of the activation and neurophysiological role of our autonomic nervous system, in a constant and ever-present ?embodied cognition?, has led the applicant of the present patent application to search for properties of clinical measurement of the autonomic and somatic nervous system. For example, the possibility to know the functionality, for survival purposes, of the temporary dissociation that occurs in a situation of the type known as ?Temporary Over Freezing? and how to intervene in the professional network makes the difference in the technological age we are living, where this condition of the Peripheral Nervous System? very present and cadenced.

In other words, being able to combine the effects and operational consequences of Temporary Over Freezing with the functions conquered in evolution by the myelinated part of the vagus (NA)? the achievement of a methodological process based on neurophysiological principles adapted to modernity? of environmental stimuli? emotions ? power ? to which the? individual ? today called to face.

The results provided by the apparatus in question (indicated generically in Fig. 3 with the output values V1, V2, V3 and V4) make it possible to verify the presence of any stress conditions not justified by the actual environmental conditions. In other words, ? possible to identify those situations of apparent but not real danger known as ?paper tigers? from real situations of danger, called ?real tigers?, in which the individual must be able to react actively when his organism consequently produces the physiological stimuli necessary to nullify this dangerous situation or at least to limit its consequences by bringing himself into a situation of ?Freezing with fear?. If, on the other hand, the individual is subject to the influence of worries, thoughts, sadness, anxiety, depression, etc., also thanks to the action of the myelinated NA vagus nerve, the condition will be the one called ?Light Freezing?, or ?Freezing without Fear?, characterized by a moderate bodily dissociation from the environment. The continuation of this condition determines an activation without reason of some functions such as, for example, those of the endocrine and immune systems which will be more? active than necessary, causing a state of general fatigue not justified by the need? of necessarily active behavior. For example, can you have a characteristic dissociative state of ?Temporary Over Freezing?, in which the man system temporarily detaches itself from? environment for a control, with a condition in which the brain, which ? still in action, it detaches and dissociates the body precisely to understand how to get out of this condition of Freezing. The absence of a solution to the problem can? lead to a condition, called ?Over Freezing?, in which the individual is unable to retain the energy in surplus and cannot? address the environment, if not with the use of external aid. One of the principles at the basis of the present invention ? related to reactivity? of the individual. For example, in a healthy, young subject, the vague NA ? responsive, quick to activate and deactivate. When he recognizes the dangerous stimulus, ?right? (the so-called ?royal tiger?), frees the sympathetic, granting maximum power to the activation of the defenses, with an ?embolied? drive of thought and movement. The responsiveness? and the fast ?flush out? of the sympathetic system, at the end of the danger, does s? that the vague NA immediately restart its activity? of ?brake?, ie manager of the enormous potential that our metabolic system guarantees.

The problem you often encounter? that this flush out doesn't happen today, does it? quickly and effectively. In other words, the so-called ?paper tigers? are constant causing anxieties, sadness or other feelings to which you do not? is it possible to provide an adequate answer why? they are not related to real dangers. Under this condition you can? add a real, unexpected fear that turns into anxiety, contributing to raising the values of the branch of the sympathetic LF.

These just described are important steps: although we are permeated by continuous and daily paper tigers, ? It is also possible to have emotional states of fear like a real tiger in which fear freezing is activated, the vague NA cancels out, autonomously releases the ?brake? to kick-start maximal metabolic power. Unfortunately, the consequent physical activation often does not occur, or at least not sufficiently to drain all the energy made available. The release of glucocorticoids lasts for tens of minutes. As soon as the danger has passed, do we resume our business? of life, hyperventilating for a few minutes or even hours. In practice, in these cases the body has implemented a series of cascade systems to guarantee the necessary energy (maximum aerobic power, given by phosphates), with possible consequent hyperventilation, noradrenaline, CRH; in the following minutes it releases hormones from the adrenal cortex (cortisol), to ensure high energy, vasopressin and aldosterone to contain liquids both at the kidney and systemic level; blood coagulation to avoid losses, digestion block, , refinement of the telereceptors, hearing set on frequencies pi? receptive.

In conclusion, there is an? activation that will not? never ?vented? (freezing in fact) and that will go? to be added to any other freezing.

Will the immune system respond? immediately with the inflammatory information process, as useful in acute cases as it is harmful in chronic cases.

This chronic activation (which is also characterized by symptoms, such as chronic fatigue) is inferred from blood markers (IL6) and symptoms (insomnia, suboptimal defecation) and a vertical reduction of the immune defenses, starting above all from salivary and duct Ig laryngopharyngeal, as sentinel of systemic and general inflammations.

The detection of cardiopulmonary and kinesthetic oscillators? to be understood as a photograph, a ?frame? immediately clear that it speaks to us of the moment of life of the client/patient and that it gives us even a presumable historian of the ?entire film?, makes us guess and deduce frame after frame, the? identity of the SN of the individual, assumption that for no one the ?film? ? the same.

In the event that the subject is pervaded by high anxiety, derived from real, environmental, or cognitively constructed fear, with the VAGAL brake released (HF low values, LF high values) we will find results in the body from activated striated muscles:

cervical?blocked? in movement, related migraines, nocturnal and daytime bruxism, hyperventilation, pelvic floor hyperactivation, hip flexor hyperactivation (psoas in primis), foot retracted in the vault by hyperactivation of the Life Line of the hindfoot.

In the event that there is a strong preponderance of the NA VAGON nerve (HF high values, LF low values), you will find? activated smooth muscle, as inferred from related symptoms and conditions:

hypertension, irritable colon, gastroesophageal reflux, asthma, sleep apnea.

Is it clear that every individual living in the western developed world can present more? symptoms, related to stressful conditions with fear and without fear, with vague NA, the brake, both strongly activated and released.

These are today's living conditions, simulating constant ?real? tigers? and constant ?paper? tigers.

For this the detection? useful even if unique, but ? very useful if carried out constantly day after day, why? provides us with the history and the summation of the ?Real Tigers? and those of ?paper?.

So an individual can report somatic symptoms both related to hyperactivation of smooth and striated muscles, simultaneously.

In the event that the vagus NA works intensely, it brakes, immobilizes partially and at times almost continue, with the body that stores energy, without having the possibility? of freeing it immediately, both limbic (place of emotions) and of movement, we have a state that is defined as ?light freezing?. This state is evaluated with the present invention through the cardiopulmonary and kinesthetic oscillators indicated above.

If the condition of ?light freezing? persists, or if the individual fails to limit the strong drive of the vague NA in response to continuous stress of multiple origins, can it? enter a condition of ?temporary over freezing?. This condition? very often frequent in our society, especially in categories of workers who suffer a lot of stress, connected and then added to social life. There are times when this condition ? note that it is sometimes referred to as burn out; well, in these cases the cardiopulmonary detection system speaks clearly compared to the kinesthetic oscillator.

The values of both LF ? friendly ? what about HF ? vague NA -, they are very low. The VLF, the PNEI, reaches very high values. Furthermore, at the level of Glucocorticoids/PNEI, the system often appears ?healthy?, physiological, if the ?temporary over freezing? ? passenger in time, if it doesn't last more? of 2/3 days.

Only the CO2 detected with the capnometer (CAP) remains low as values, below the 36 mm/Hg of reference, while the hormonal system performs a rapid flush out, aesthetically characterized only by an accumulation of extracellular fluids and by the usual lack of urination early morning.

In this case ? a detection with the relative device (BIA) is necessary to directly evaluate the extracellular water compared to the intracellular one.

For all, the condition of continuous brake to external stress, pu? lead to the condition pi? dangerous, known as ?exhaustion of the vago na brake?.

If the paper tigers increase, due to the failure to zero, through lack of movement and coaching and over time they add up together with the continuous real tigers, characterized by anxious stress peaks, the brake wears out and ends, with the ?activation of the dorsal vagus DMNX, leading to a condition of over freezing. Decisive detail in the evaluation of the Test performed with the equipment (1) ? deduce, through the Rmssd frequency and time domains, and adipometry, the presence of a central glucocorticoid resistance, a condition to be inferred in the event that the VLF are low (lack of neuroendrocin activation due to central resistance and presumable related thyroid deficits, from function ?clock? of the same gland), while the values of the sympathetic are high, condition perpetuated in the surveys day after day.

This leads us to conclude that the biofeedback system is altered, that there is a presence of white visceral fat, an emitter of inflammatory cytokines with low, almost no activity. energy of the mitochondria.

Exchange with the medical figure responsible for the client/patient is necessary, in order to direct analyzes and subsequent therapeutic processes and above all the Movement, which could presumably worsen a nascent condition of cellular dys-regulation on an anaerobic basis.

Specifically a modality? of cross-check on?the induction of the case, you can? carry out by doing activities? respiratory Buteyko, checking if the VLFs have a peak in the next measurement, clearly attributable to a positive acute response of the amygdala-hippocampus-HPA axis process); condition for which timed operational choices can be made based on clinical data, relating to the re-entry of movement as the keystone in an embodied optimization (the movement reactivates the mitochondria, with antiox properties, releases BDNF and osteocrine, mediators brain health chemicals).

When this happens, can presumably confirm the correctness of the previously assumed assessment.

This condition of Freezing, with steps pi? or less repeated or permanent, lead over time to impoverish and make the immune system ineffective, suppressing it and paving the way for more and more diseases. usual autoimmune pathologies, dermatitis, Chron, celiac disease.

At this juncture, a possible presence of pituitary hyperactivation in the emission of neurotransmitters and hormones is understood, deduced and measured, aimed at bringing the body back to sectoral homeostasis and systemic allostasis, translated: if the person has glucocorticoid hypersecretion.

This data detected by the heart rate variation detector (HRV) and the capnograph (CAP) is directly compared with the fat monitor (ADI) (for example a Hosand fat monitor), which precisely detects the level of hormone fat.

In practice, if an altered state of SAT ?superficial adipose tissue? is detected, there is direct confirmation of chronic cortisol hyperactivation by adrenal ACTH, with loss of morning urination, disturbances in defecation (feces with water, which is not reabsorbed in the colon given the stress and the inflammatory state).

The C02 appears normal, indeed, it often rises again in the values, around the sufficient 36 mm/hg. This happens why? the upper hand of the dorsal vagus DMNX does s? that the conditions are created for a complete dissociation from the environment and for a progressive leveling downwards of the vital levels. Forerunner in this physiological condition are sleep apnea.

Wanting to summarize the operation of the equipment (1) ? can be said to include:

A) Detecting the oscillatory frequencies of the dynamic gait rhythms defined as ?Forward Locomotor Movement? through an isoinertial sensor (for example of the Sensor Medica type), from which the oscillatory frequency of the individual's Center of Mass is obtained, after a comparative study with a dynamic baropodometric platform (for example, of the Sensor Medica type) supplied with pressure gauges (capacitive and psychics) that detect force domains. The sensor, through a Fourier transform, obtains the frequency from the time. The sensor must be positioned in correspondence with the L3 vertebra.

B) Detecting static rhythm oscillators such as neck and hip. In this case we focus on the properties? oscillation of the arthromuscular districts mentioned: the neck for its anatomo-functional characteristics? called by me? Spine kinesthetic oscillator?, ? an excellent detector of incapacity? and osteoarticular dysfunction in swing during movement. Degrees of left and right rotation of C2 with locked C3 to C7 vertebrae are measured by practitioner performing anterior skull flexion.

The neck (vertebrae C1 to C7) connects the two ?cranial vertebrae? occiput sphenoid, to the vertebral column, which starting from T1 assumes the classic scoliosis, which are functional to pass oscillatory lines of force of walking.

If the gait is centrally altered by the SN for various reasons, emotional, i.e. anxiety, fear, anger, etc. (reduced to the base emotions and correlated mood states), the power output on the hip will be deficit. In this case, to see if there ? such a problem, you always run the Leg Raise test exercise, which detects degrees and speeds? via isoinertial sensor.

The R.O.M. of both tests is recorded. range of motion through the use of isoinertial sensors.

In the case of the Leg Raise the aforementioned sensors will also calculate the speed? angular, to better extract the deficit, as it is directly correlated with a movement test equipped with summary software of the practical test.

With these tests, which can therefore be three (static oscillators of the cervical, hip and dynamic oscillators of the walk, through, in fact, the oscillations of the Center of Mass in L3), we assume the quality? of the kinesthetic oscillators, which are part of the peripheral nervous system, the ?somatic? part.

To measure the autonomic part of the Peripheral Nervous System, let's use: HRV heart rate variability detector, for example by Hosand: with this detection, through the algorithm that will come? created in comparison of the data acquired from the Rmssd time domains and the VLF frequency ? HF ? LF, in order very low frequency, high frequency and low frequency, are able to read (even without algorithm), the emotional state and autonomic nervous activation of the subject, the cio? as ? place in the environment.

? possible to identify with absolute certainty whether the subject? in a state of sympathetic hyperactivation, if in dissociation of body and mind from the environment, if in a state of ?Freezing?, both momentary and recurring, both Light and Over.

This ? possible thanks to the comparison with the data detected by the capnograph (for example of the Maximo type), which provides data of endogenous CO2 pressure and breaths per minute.

When the LF are high and the HF are low, with a high intake of VLF are we in the presence of light freezing? fearful or fearless dissociation, confirmed by capnography with high ventilatory activity and low endogenous CO2 levels.

When the HF and LF are low tending to zero and the VLF high, we are in the presence of over freezing, confirmed by capnography with normal breaths, almost low and normal CO2, tending to rise.

HRVs give me a history of the subject, capnography an immediate emotional state. Data that are used to deduce if the Over Freezing is temporary and with the possibility? of ?exit? fast (very important the historian of the Rmssd) or lasting and therefore worthy of pi? Attention.

These are called cardio-pulmonary oscillators and are they related to Porges' polyvagal theory implemented by biochemical oxygen exchange concepts? carbon dioxide.

The part of the Peripheral Nervous system pu? be compared by interfacing with a hair analyzer (SDR), for example of the Epinutracell S-Drive type. This device, which adopts oscillatory concepts to resonate the ?forfeited? in the hair of the subject, there d? a very detailed and accurate situation of the epigenetic biological oscillator.

Epinutracell's S-drive provides the biological state of each body system.

Vary and synchronize the autonomic and somatic oscillators, porter? to have better data, biological, from? S-drive.

In conclusion, this equipment (1) can? foresee:

- detection by static kinesthetic oscillators of the neck and hip and dynamic kinesthetic oscillators of forward locomotor move (SEN);

- the detection by cardiopulmonary oscillators (HRV) and (CAP) of heart and breathing;

- comparison through reference data; And

- the comparison with the values of the adipometer (ADI) and bioimpedance meter (BIA) to provide an output series of values which can be, for example:

- (V1), or ?green light?: normal data, synchronized, by activity? of movement, adequately positive emotional state.

- (V2), or ?red light?: movement or cardiopulmonary data not normal, absolutely not synchronized, recovery of the autonomic system not completed: Stop prescribed.

- (V3), or ?yellow light?: data not fully synchronized, Light Freezing, movement can be performed according to a pre-established method and mental coaching.

- (V4), or ?Orange light?: dissociated state, prolonged Over Freezing in progress, urgent adjustment of exercises and therapist session.

Furthermore, from the test carried out by the hair analyzer (SDR), the output signal can involve food advice from a nutritionist biologist.

The examples proposed are not to be considered in a limiting sense since? the method that can be implemented using the equipment in question allows to operate on all the variables, or to intervene in all the aforementioned conditions of ?frrezing with fear?, ?freezing without fear?, temporary over freezing?, ?over freezing?.

Naturally, the invention is not limited to what is described and illustrated, but pu? be widely varied as regards the arrangement, shape and nature of the components used without thereby abandoning the inventive teaching set out above and hereinafter claimed.

Claims (10)

1. Equipment for measuring physiological parameters that can be used to determine, through the combination of measured values and comparison of these values with reference values, the general state of health of an individual as a whole, or to obtain a general value that takes account also of the interactions between the autonomic peripheral nervous system and the somatic one, a device characterized by the fact that it includes: - a detector of the variability? heart rate (HRV) related to the individual being examined; - a capnograph (CAP) capable of detecting a CO2 value of the individual under examination; - a unit? central (UC) connected in input to said detector of the variability? of the heart beat frequency (HRV) and to said capnograph (CAP) and equipped with a software (ALG) able to supply in output a value (V1, V2, V3, V4) corresponding to the combined evaluation of the data received in input. 2. Apparatus according to claim 1, characterized in that it comprises an isoinertial sensor (SEN) connected to the input of said unit? central and including a motion sensor that can be positioned at the height of the lumbar area of the individual being examined. 3. Apparatus according to claim 1, characterized in that it comprises an isoinertial sensor (SEN) connected to the input of said unit? central and including a motion sensor that can be positioned at the height of the lumbar area of the individual in question and one or more? static sensors. 4. Apparatus according to claim 2 or 3, characterized in that said isoinertial sensor (SEN) supplies a datum relating to a frequency. 5. Apparatus according to one of the preceding claims, characterized in that it also comprises one or more devices of the group comprising: - an adipometer (ADI), - a bioimpedance meter (BIA) e - a hair bulb analyzer (SDR). 6. Apparatus according to one of the preceding claims, characterized in that the software (ALG) suitable for processing the data received at the entrance from said unit? central (CU) ? set so as to consider the following readings as standard: - for the detector of the variability? of heart rate (HRV): VLF value of about 23 (? 5)%, LF value of about 25 (? 5)%, HF value of about 51 (? 5)%, with a value of rMSSD between 40 (? 5) and 60 (? 5); - for the capnograph (CAP) a value of mmHg CO2 ? 36 mmHg. 7. Apparatus according to one of the preceding claims, characterized in that said detector of the variability? heart rate (HRV) ? connected to the individual under examination by means of electrodes. 8. Apparatus according to one of the preceding claims, characterized in that said capnograph (CAP) ? connected to the individual under examination by tubes to the nostrils. 9. Apparatus according to one of the preceding claims, characterized in that the values of said adipometer (ADI) and/or of said bioimpedance meter (BIA) are provided in image format. 10. Apparatus according to claim 2 and/or 3, characterized in that the data received from said detector of the variability? of the heart beat frequency (HRV) and by said capnograph (CAP) are used for evaluations relating to the autonomic nervous system (I) so as to define a cardio-pulmonary oscillator and the data received from said isoinertial sensor (SEN) are used for evaluations related to the somatic nervous system (II) in order to define a kinesthetic oscillator.