IT1255462B - METHOD OF PREPARATION OF NIMESULIDE INCLUSION COMPOUNDS WITH CYCLODESTRINE - Google Patents
METHOD OF PREPARATION OF NIMESULIDE INCLUSION COMPOUNDS WITH CYCLODESTRINEInfo
- Publication number
- IT1255462B IT1255462B ITMI921833A ITMI921833A IT1255462B IT 1255462 B IT1255462 B IT 1255462B IT MI921833 A ITMI921833 A IT MI921833A IT MI921833 A ITMI921833 A IT MI921833A IT 1255462 B IT1255462 B IT 1255462B
- Authority
- IT
- Italy
- Prior art keywords
- nimesulide
- preparation
- cyclodestrine
- inclusion compounds
- milling
- Prior art date
Links
- HYWYRSMBCFDLJT-UHFFFAOYSA-N nimesulide Chemical compound CS(=O)(=O)NC1=CC=C([N+]([O-])=O)C=C1OC1=CC=CC=C1 HYWYRSMBCFDLJT-UHFFFAOYSA-N 0.000 title abstract 3
- 229960000965 nimesulide Drugs 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 229920000858 Cyclodextrin Polymers 0.000 abstract 2
- 238000003801 milling Methods 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 229940097362 cyclodextrins Drugs 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 239000008240 homogeneous mixture Substances 0.000 abstract 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 abstract 1
- 239000008247 solid mixture Substances 0.000 abstract 1
- 238000001694 spray drying Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nanotechnology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Si descrive un metodo per la preparazione di composti di inclusione di nimesulide con ciclodestrine che consiste nel sottoporre una miscela solida, una soluzione acquosa o un impasto omogeneo di nimesulide e ciclodestrina idrosolubile rispettivamente a co-mulinazione, essiccamento spray o mulinazione ed essiccazione.A method for the preparation of inclusion compounds of nimesulide with cyclodextrins is described which consists in subjecting a solid mixture, an aqueous solution or a homogeneous mixture of nimesulide and water soluble cyclodextrin to co-milling, spray drying or milling and drying respectively.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI921833A IT1255462B (en) | 1992-07-28 | 1992-07-28 | METHOD OF PREPARATION OF NIMESULIDE INCLUSION COMPOUNDS WITH CYCLODESTRINE |
PCT/EP1993/001560 WO1994002177A1 (en) | 1992-07-28 | 1993-06-18 | Method of preparation of inclusion compounds of nimesulide with cyclodextrins |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI921833A IT1255462B (en) | 1992-07-28 | 1992-07-28 | METHOD OF PREPARATION OF NIMESULIDE INCLUSION COMPOUNDS WITH CYCLODESTRINE |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI921833A0 ITMI921833A0 (en) | 1992-07-28 |
ITMI921833A1 ITMI921833A1 (en) | 1994-01-28 |
IT1255462B true IT1255462B (en) | 1995-11-02 |
Family
ID=11363762
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITMI921833A IT1255462B (en) | 1992-07-28 | 1992-07-28 | METHOD OF PREPARATION OF NIMESULIDE INCLUSION COMPOUNDS WITH CYCLODESTRINE |
Country Status (2)
Country | Link |
---|---|
IT (1) | IT1255462B (en) |
WO (1) | WO1994002177A1 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA57734C2 (en) | 1996-05-07 | 2003-07-15 | Пфайзер Інк. | Arylheterocyclic inclusion complexes |
IT1298732B1 (en) * | 1998-03-13 | 2000-02-02 | Recordati Chem Pharm | ORAL PHARMACEUTICAL COMPOSITIONS ASSUMABLE WITHOUT LIQUIDS, CONTAINING INCLUSION COMPLEXES |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1227626B (en) * | 1988-11-28 | 1991-04-23 | Vectorpharma Int | SUPPORTED DRUGS WITH INCREASED DISSOLUTION SPEED AND PROCEDURE FOR THEIR PREPARATION |
ES2023552A6 (en) * | 1990-05-22 | 1992-01-16 | Leetrim Limited | Nimesulid inclusion cpds. with cyclodextrin - more water-soluble with improved bio-availability than nimesulid alone |
IT1248475B (en) * | 1990-05-22 | 1995-01-19 | Angeli Inst Spa | INCLUSION COMPOUNDS OF NIMESULIDE WITH CYCLODESTRINE |
-
1992
- 1992-07-28 IT ITMI921833A patent/IT1255462B/en active IP Right Grant
-
1993
- 1993-06-18 WO PCT/EP1993/001560 patent/WO1994002177A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
ITMI921833A0 (en) | 1992-07-28 |
WO1994002177A1 (en) | 1994-02-03 |
ITMI921833A1 (en) | 1994-01-28 |
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