IT1255179B - AZACICLO AND AZABICICLO ALCHILIDEN IDROSSILAMINE - Google Patents

AZACICLO AND AZABICICLO ALCHILIDEN IDROSSILAMINE

Info

Publication number
IT1255179B
IT1255179B ITMI921571A ITMI921571A IT1255179B IT 1255179 B IT1255179 B IT 1255179B IT MI921571 A ITMI921571 A IT MI921571A IT MI921571 A ITMI921571 A IT MI921571A IT 1255179 B IT1255179 B IT 1255179B
Authority
IT
Italy
Prior art keywords
idrossilamine
azaciclo
alchiliden
azabiciclo
formula
Prior art date
Application number
ITMI921571A
Other languages
Italian (it)
Inventor
Enzo Cereda
Angelo Sagrada
Giovanni Battista Schiavi
Original Assignee
Enzo Cereda
Angelo Sagrada
Giovanni Battista Schiavi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enzo Cereda, Angelo Sagrada, Giovanni Battista Schiavi filed Critical Enzo Cereda
Priority to ITMI921571A priority Critical patent/IT1255179B/en
Publication of ITMI921571A0 publication Critical patent/ITMI921571A0/en
Priority to TW082104055A priority patent/TW225523B/zh
Priority to MX9303443A priority patent/MX9303443A/en
Priority to AU43253/93A priority patent/AU4325393A/en
Priority to PCT/EP1993/001493 priority patent/WO1994000448A1/en
Priority to SI9300331A priority patent/SI9300331A/en
Priority to CN93108003.7A priority patent/CN1084516A/en
Publication of ITMI921571A1 publication Critical patent/ITMI921571A1/en
Application granted granted Critical
Publication of IT1255179B publication Critical patent/IT1255179B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/08—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Sono descritte azaciclo e azabiciclo alchiliden idrossilammine farmacologicamente attive come agenti colinergici, utili nel trattamento di disturbi neurologici e mentali, dì formula generale (I) (FORMULA I) nella quale A, n, R1 e R2 hanno i significati dati nella descrizione, un processo per la loro preparazione e composizioni farmaceutiche che le contengono.Pharmacologically active azacyclo and azabicyclo alkyliden hydroxylamines are described as cholinergic agents, useful in the treatment of neurological and mental disorders, of the general formula (I) (FORMULA I) in which A, n, R1 and R2 have the meanings given in the description, a process for their preparation and pharmaceutical compositions that contain them.

ITMI921571A 1992-06-26 1992-06-26 AZACICLO AND AZABICICLO ALCHILIDEN IDROSSILAMINE IT1255179B (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
ITMI921571A IT1255179B (en) 1992-06-26 1992-06-26 AZACICLO AND AZABICICLO ALCHILIDEN IDROSSILAMINE
TW082104055A TW225523B (en) 1992-06-26 1993-05-22
MX9303443A MX9303443A (en) 1992-06-26 1993-06-09 ALKYLIDEN-HYDROXYLAMINES AZACICLICAS AND AZABICICLICAS, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
AU43253/93A AU4325393A (en) 1992-06-26 1993-06-14 Azacyclic and azabicyclic hydroxylamines as muscarinic receptor agonists
PCT/EP1993/001493 WO1994000448A1 (en) 1992-06-26 1993-06-14 Azacyclic and azabicyclic hydroxylamines as muscarinic receptor agonists
SI9300331A SI9300331A (en) 1992-06-26 1993-06-23 Azabicyclo and azabicycloalkyldien hydroxylamines
CN93108003.7A CN1084516A (en) 1992-06-26 1993-06-26 Nitrogen heterocyclic and azabicyclic alkyliden hydroxylamines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI921571A IT1255179B (en) 1992-06-26 1992-06-26 AZACICLO AND AZABICICLO ALCHILIDEN IDROSSILAMINE

Publications (3)

Publication Number Publication Date
ITMI921571A0 ITMI921571A0 (en) 1992-06-26
ITMI921571A1 ITMI921571A1 (en) 1993-12-26
IT1255179B true IT1255179B (en) 1995-10-20

Family

ID=11363581

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI921571A IT1255179B (en) 1992-06-26 1992-06-26 AZACICLO AND AZABICICLO ALCHILIDEN IDROSSILAMINE

Country Status (7)

Country Link
CN (1) CN1084516A (en)
AU (1) AU4325393A (en)
IT (1) IT1255179B (en)
MX (1) MX9303443A (en)
SI (1) SI9300331A (en)
TW (1) TW225523B (en)
WO (1) WO1994000448A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19547759A1 (en) * 1995-12-20 1997-06-26 Basf Ag Stabilized hydroxylamine solutions
PT805153E (en) * 1996-04-30 2002-03-28 Pfizer NEW MUSCLE RECEPTOR AGONISTS
WO2009125434A2 (en) * 2008-04-07 2009-10-15 Cadila Healthcare Limited Oxime derivatives
UA121503C2 (en) 2015-06-26 2020-06-10 Такеда Фармасьютікал Компані Лімітед 2,3-dihydro-4h-1,3-benzoxazin-4-one derivatives as modulators of cholinergic muscarinic m1 receptor
US10548899B2 (en) 2015-10-20 2020-02-04 Takeda Pharmaceutical Company Limited Quinazolinone and benzotriazinone compounds with cholinergic muscarinin M1 receptor positive allosteric modulator activity

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3301689A (en) * 1988-04-15 1989-10-26 Beecham Group Plc 1-azabicyclo-alkyl derivatives
YU84791A (en) * 1990-05-19 1994-06-10 Boehringer Ingelheim Kg. BICYCLIC 1-AZA-CYCLOALKAL

Also Published As

Publication number Publication date
AU4325393A (en) 1994-01-24
ITMI921571A0 (en) 1992-06-26
TW225523B (en) 1994-06-21
WO1994000448A1 (en) 1994-01-06
CN1084516A (en) 1994-03-30
MX9303443A (en) 1994-01-31
SI9300331A (en) 1993-12-31
ITMI921571A1 (en) 1993-12-26

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Legal Events

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0001 Granted