IN2015DN00960A - - Google Patents
Download PDFInfo
- Publication number
- IN2015DN00960A IN2015DN00960A IN960DEN2015A IN2015DN00960A IN 2015DN00960 A IN2015DN00960 A IN 2015DN00960A IN 960DEN2015 A IN960DEN2015 A IN 960DEN2015A IN 2015DN00960 A IN2015DN00960 A IN 2015DN00960A
- Authority
- IN
- India
- Prior art keywords
- compounds
- methods
- general formula
- provides novel
- compositions including
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention provides novel compounds having the general formula (I) wherein R1, Y, A, W, R2, m, n, p and q are as described herein compositions including the compounds and methods of using the compounds.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12185941 | 2012-09-25 | ||
| PCT/EP2013/069679 WO2014048865A1 (en) | 2012-09-25 | 2013-09-23 | New bicyclic derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2015DN00960A true IN2015DN00960A (en) | 2015-06-12 |
Family
ID=47073290
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN960DEN2015 IN2015DN00960A (en) | 2012-09-25 | 2013-09-23 |
Country Status (33)
| Country | Link |
|---|---|
| US (4) | US20150353559A1 (en) |
| EP (2) | EP2900669B1 (en) |
| JP (1) | JP6285444B2 (en) |
| KR (1) | KR102179599B1 (en) |
| CN (1) | CN104684915B (en) |
| AR (1) | AR092645A1 (en) |
| AU (1) | AU2013322838B2 (en) |
| BR (1) | BR112015004111A2 (en) |
| CA (1) | CA2878442A1 (en) |
| CL (1) | CL2015000706A1 (en) |
| CR (1) | CR20150120A (en) |
| DK (1) | DK2900669T3 (en) |
| EA (1) | EA036630B1 (en) |
| ES (1) | ES2753163T3 (en) |
| HK (1) | HK1206722A1 (en) |
| HR (1) | HRP20191937T1 (en) |
| HU (1) | HUE045797T2 (en) |
| IL (1) | IL237126A (en) |
| IN (1) | IN2015DN00960A (en) |
| LT (1) | LT2900669T (en) |
| MA (1) | MA37940B1 (en) |
| MX (1) | MX368615B (en) |
| PE (1) | PE20150758A1 (en) |
| PH (1) | PH12015500263B1 (en) |
| PL (1) | PL2900669T3 (en) |
| PT (1) | PT2900669T (en) |
| RS (1) | RS59512B1 (en) |
| SG (1) | SG11201500572YA (en) |
| SI (1) | SI2900669T1 (en) |
| TW (1) | TWI609018B (en) |
| UA (1) | UA116547C2 (en) |
| WO (1) | WO2014048865A1 (en) |
| ZA (1) | ZA201500345B (en) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104364239B (en) | 2012-06-13 | 2017-08-25 | 霍夫曼-拉罗奇有限公司 | Diaza spiro cycloalkane and azaspiro alkane |
| MX368615B (en) | 2012-09-25 | 2019-10-09 | Hoffmann La Roche | New bicyclic derivatives. |
| US9409895B2 (en) | 2012-12-19 | 2016-08-09 | Novartis Ag | Autotaxin inhibitors |
| KR20150095888A (en) | 2012-12-19 | 2015-08-21 | 노파르티스 아게 | Autotaxin inhibitors |
| AR095079A1 (en) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | DERIVATIVES OF OCTAHIDRO-PIRROLO [3,4-C] -PIRROL AND PIRIDINA-FENILO |
| US9828379B2 (en) | 2013-07-03 | 2017-11-28 | Abide Therapeutics, Inc. | Pyrrolo-pyrrole carbamate and related organic compounds, pharmaceutical compositions, and medical uses thereof |
| US9540324B2 (en) * | 2013-09-26 | 2017-01-10 | Luc Therapeutics, Inc. | Selective octahydro-cyclopenta[C] pyrrole negative modulators of NR2B |
| NZ720478A (en) | 2013-11-22 | 2022-02-25 | Sabre Therapeutics Llc | Autotaxin inhibitor compounds |
| HUE036117T2 (en) * | 2013-11-26 | 2018-06-28 | Hoffmann La Roche | Octahydro-cyclobuta [1,2-c;3,4-c']dipyrrole derivatives as autotaxin inhibitors |
| MA39792B1 (en) * | 2014-03-26 | 2019-12-31 | Hoffmann La Roche | Bicyclic compounds as inhibitors of autotaxin (atx) and lysophosphatidic acid (lpa) production |
| CN106029667B (en) | 2014-03-26 | 2019-08-23 | 豪夫迈·罗氏有限公司 | Condensed [1,4] diaza * compound as autocrine motility factor (ATX) and lysophosphatidic acid (LPA) production inhibitor |
| US9051320B1 (en) | 2014-08-18 | 2015-06-09 | Pharmakea, Inc. | Methods for the treatment of metabolic disorders by a selective small molecule autotaxin inhibitor |
| JO3579B1 (en) | 2014-09-26 | 2020-07-05 | Luc Therapeutics Inc | N-alkylaryl-5-oxyaryl- octahydro-cyclopenta[c]pyrrole negative allosteric modulators of nr2b |
| GB201501870D0 (en) | 2015-02-04 | 2015-03-18 | Cancer Rec Tech Ltd | Autotaxin inhibitors |
| GB201502020D0 (en) | 2015-02-06 | 2015-03-25 | Cancer Rec Tech Ltd | Autotaxin inhibitory compounds |
| MA41898A (en) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | BICYCLIC QUINAZOLINONE DERIVATIVES |
| EP3302490B1 (en) | 2015-05-27 | 2022-04-13 | Sabre Therapeutics LLC | Autotaxin inhibitors and uses thereof |
| AU2016270373A1 (en) | 2015-06-05 | 2018-01-04 | Vertex Pharmaceuticals Incorporated | Triazoles for the treatment of demyelinating diseases |
| UA123362C2 (en) | 2015-09-04 | 2021-03-24 | Ф. Хоффманн-Ля Рош Аг | Phenoxymethyl derivatives |
| WO2017050791A1 (en) * | 2015-09-24 | 2017-03-30 | F. Hoffmann-La Roche Ag | New bicyclic compounds as dual atx/ca inhibitors |
| CA2991615A1 (en) * | 2015-09-24 | 2017-03-30 | F. Hoffmann-La Roche Ag | Bicyclic compounds as atx inhibitors |
| AU2016328535A1 (en) * | 2015-09-24 | 2017-11-09 | F. Hoffmann-La Roche Ag | Bicyclic compounds as ATX inhibitors |
| CN107614505B (en) | 2015-09-24 | 2021-05-07 | 豪夫迈·罗氏有限公司 | Novel bicyclic compounds as dual ATX/CA inhibitors |
| CN106986789B (en) * | 2016-01-20 | 2019-07-16 | 中国人民解放军军事医学科学院生物医学分析中心 | Hydroquinone compound and preparation method thereof and the application in antitumor or immunological regulation |
| US10030020B2 (en) | 2016-05-12 | 2018-07-24 | Abide Therapeutics, Inc. | Spirocycle compounds and methods of making and using same |
| JOP20190107A1 (en) | 2016-11-16 | 2019-05-09 | Lundbeck La Jolla Research Center Inc | Magl inhibitors |
| WO2018106646A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Aminotriazoles for the treatment of demyelinating diseases |
| WO2018106641A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Pyrazoles for the treatment of demyelinating diseases |
| WO2018106643A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Heterocyclic azoles for the treatment of demyelinating diseases |
| EP3555101A2 (en) | 2016-12-19 | 2019-10-23 | Bayer Pharma Aktiengesellschaft | [(phenylsulfonyl)octahydro-epiminoisoindol-yl](1h-1,2,3-triazol-5-yl)methanones |
| WO2018167113A1 (en) * | 2017-03-16 | 2018-09-20 | F. Hoffmann-La Roche Ag | New bicyclic compounds as atx inhibitors |
| AU2018233079B9 (en) | 2017-03-16 | 2021-07-22 | F. Hoffmann-La Roche Ag | Heterocyclic compounds useful as dual ATX/CA inhibitors |
| PL3448859T3 (en) | 2017-03-20 | 2020-02-28 | Forma Therapeutics, Inc. | Pyrrolopyrrole compositions as pyruvate kinase (pkr) activators |
| AU2018323459A1 (en) | 2017-08-29 | 2020-02-20 | H. Lundbeck A/S. | Spirocycle compounds and methods of making and using same |
| RU2020107039A (en) | 2017-08-29 | 2021-09-30 | Лундбекк Ла-Хойя Рисерч Сентер, Инк. | SPIROCYCLIC COMPOUNDS AND METHODS FOR THEIR PREPARATION AND APPLICATION |
| US11548868B2 (en) | 2017-10-19 | 2023-01-10 | Js Innopharm (Shanghai) Ltd. | Heterocyclic compounds, compositions comprising heterocyclic compound, and methods of use thereof |
| TWI780281B (en) * | 2017-12-14 | 2022-10-11 | 丹麥商Ｎｍｄ藥品公司 | Compounds for the treatment of neuromuscular disorders |
| US20200129485A1 (en) | 2018-09-19 | 2020-04-30 | Forma Therapeutics, Inc. | Treating sickle cell disease with a pyruvate kinase r activating compound |
| JP7450610B2 (en) | 2018-09-19 | 2024-03-15 | ノヴォ・ノルディスク・ヘルス・ケア・アーゲー | Activation of pyruvate kinase R |
| CN111620866A (en) * | 2019-02-27 | 2020-09-04 | 南京药石科技股份有限公司 | Cis-7, 7-difluoro-hexahydro-1H pyrrolo [3,4-c ] pyridine derivative and preparation method thereof |
| CN113549063B (en) * | 2020-04-23 | 2024-04-05 | 南京药石科技股份有限公司 | Preparation method of optical isomerism octahydro-2H-pyrrolo [3,4-c ] pyridine-2-tert-butyl carboxylate |
| WO2022003557A1 (en) * | 2020-06-30 | 2022-01-06 | Cadila Healthcare Limited | Novel inhibitors of autotaxin |
| TW202229255A (en) | 2020-11-13 | 2022-08-01 | 丹麥商Ｈ 朗德貝克公司 | A magl inhibitor |
| CN113214111A (en) * | 2021-04-30 | 2021-08-06 | 上海立科化学科技有限公司 | Preparation method of 3- (2-cyanophenyl) propionic acid and 4-cyano-1-indanone |
Family Cites Families (125)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1252898B (en) | 1965-06-12 | 1967-10-26 | Bayer Ag | Process for the preparation of copolymers of trioxane |
| US5240928A (en) | 1989-07-03 | 1993-08-31 | Merck & Co., Inc. | Substituted quinazolinones as angiotensin II antagonists |
| DE3930262A1 (en) | 1989-09-11 | 1991-03-21 | Thomae Gmbh Dr K | CONDENSED DIAZEPINONE, METHOD FOR THE PRODUCTION THEREOF AND MEDICAMENT CONTAINING THESE COMPOUNDS |
| CA2037630C (en) | 1990-03-07 | 2001-07-03 | Akira Morimoto | Nitrogen-containing heterocylic compounds, their production and use |
| US5470975A (en) | 1990-10-16 | 1995-11-28 | E.R. Squibb & Sons, Inc. | Dihydropyrimidine derivatives |
| US5290780A (en) | 1991-01-30 | 1994-03-01 | American Cyanamid Co. | Angiotensin II receptor blocking 2,3,6 substituted quinazolinones |
| US5238942A (en) | 1991-05-10 | 1993-08-24 | Merck & Co., Inc. | Substituted quinazolinones bearing acidic functional groups as angiotensin ii antagonists |
| US5202322A (en) | 1991-09-25 | 1993-04-13 | Merck & Co., Inc. | Quinazolinone and pyridopyrimidine a-II antagonists |
| US5532243A (en) | 1992-02-14 | 1996-07-02 | The Dupont Merck Pharmaceutical Company | Antipsychotic nitrogen-containing bicyclic compounds |
| US5358951A (en) | 1993-04-23 | 1994-10-25 | American Cyanamid Company | Angiotensin II receptor blocking 2, 3, 6 substituted quinazolinones |
| DE4407047A1 (en) * | 1994-03-03 | 1995-09-07 | Merck Patent Gmbh | Acetamide |
| US20010016657A1 (en) * | 1997-03-18 | 2001-08-23 | Smithkline Beecham P.L.C. | Substituted isoquinoline derivatives and their use as anticonvulsants |
| EP1061076B1 (en) | 1998-02-04 | 2004-12-08 | Banyu Pharmaceutical Co., Ltd. | N-acyl cyclic amine derivatives |
| JP2001039950A (en) | 1999-07-30 | 2001-02-13 | Banyu Pharmaceut Co Ltd | N-acyl cyclic amine derivative |
| DE60005545D1 (en) | 1999-10-27 | 2003-10-30 | Millennium Pharm Inc | PYRIDYL-CONTAINING SPIROCYCLIC COMPOUNDS AS INHIBITORS OF FIBRINOGEN-DEPENDENT BLOOD PLATE AGGREGATION |
| DK1233787T3 (en) | 1999-11-09 | 2005-08-15 | Sod Conseils Rech Applic | Product that inhibits signal transduction from heterotrimeric G proteins, combined with another anticancer agent for therapeutic use in cancer treatment |
| MXPA03008109A (en) | 2001-03-07 | 2003-12-12 | Pfizer Prod Inc | Modulators of chemokine receptor activity. |
| WO2003086288A2 (en) | 2002-04-12 | 2003-10-23 | Merck & Co., Inc. | Bicyclic amides |
| GB0303852D0 (en) | 2003-02-19 | 2003-03-26 | Pfizer Ltd | Triazole compounds useful in therapy |
| WO2005023762A1 (en) | 2003-09-04 | 2005-03-17 | Abbott Laboratories | Pyrrolidine-2-carbonitrile derivatives and their use as inhibitors of dipeptidyl peptidase-iv (dpp-iv) |
| SE0302811D0 (en) | 2003-10-23 | 2003-10-23 | Astrazeneca Ab | Novel compounds |
| GB0324790D0 (en) | 2003-10-24 | 2003-11-26 | Astrazeneca Ab | Amide derivatives |
| US7226951B2 (en) | 2003-12-17 | 2007-06-05 | Allergan, Inc. | Compounds having selective cytochrome P450RAI-1 or selective cytochrome P450RAI-2 inhibitory activity and methods of obtaining the same |
| US7435831B2 (en) * | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
| CA2558211C (en) | 2004-03-03 | 2013-09-03 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
| DE602005004144T2 (en) | 2004-06-09 | 2009-01-29 | F. Hoffmann-La Roche Ag | OCTAHYDROPYRROLOA 3,4-CYPROLREDIVES AND THEIR USE AS ANTIVIRAL AGENTS |
| CN101035773B (en) | 2004-08-10 | 2012-06-06 | 詹森药业有限公司 | HIV inhibiting 1.2.4-triazin-6-one derivates |
| US7410949B2 (en) | 2005-01-18 | 2008-08-12 | Hoffmann-La Roche Inc. | Neuropeptide-2 receptor (Y-2R) agonists and uses thereof |
| CN101166736B (en) | 2005-04-28 | 2013-02-06 | 惠氏公司 | Polymorph form II of tanaproget |
| US7737279B2 (en) | 2005-05-10 | 2010-06-15 | Bristol-Myers Squibb Company | 1,6-dihydro-1,3,5,6-tetraaza-as-indacene based tricyclic compounds and pharmaceutical compositions comprising same |
| TW200800999A (en) | 2005-09-06 | 2008-01-01 | Astrazeneca Ab | Novel compounds |
| PL1942108T3 (en) | 2005-10-28 | 2014-03-31 | Ono Pharmaceutical Co | Compound containing basic group and use thereof |
| EP3112349A3 (en) * | 2005-11-14 | 2017-03-01 | Purdue Research Foundation | A process for preparing n-substituted indenoisoquinolines |
| PT1961744E (en) | 2005-11-18 | 2013-05-15 | Ono Pharmaceutical Co | Basic group-containing compound and use thereof |
| US20070208001A1 (en) | 2006-03-03 | 2007-09-06 | Jincong Zhuo | Modulators of 11- beta hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same |
| JP2008031064A (en) | 2006-07-27 | 2008-02-14 | Astellas Pharma Inc | Diacylpiperazine derivative |
| US7820649B2 (en) | 2006-09-11 | 2010-10-26 | N.V. Organon | Quinazolinone and isoquinolinone acetamide derivatives |
| MX2009002923A (en) | 2006-09-15 | 2009-03-31 | Schering Corp | Spiro-condensed azetidine derivatives useful in treating pain, diabetes and disorders of lipid metabilism. |
| US8735411B2 (en) | 2006-10-02 | 2014-05-27 | Abbvie Inc. | Macrocyclic benzofused pyrimidine derivatives |
| WO2008059026A1 (en) | 2006-11-15 | 2008-05-22 | High Point Pharmaceuticals, Llc | Novel 2-(2-hydroxyphenyl)benzimidazoles useful for treating obesity and diabetes |
| TW200831085A (en) | 2006-12-13 | 2008-08-01 | Merck & Co Inc | Non-nucleoside reverse transcriptase inhibitors |
| EP1975165A1 (en) | 2007-03-27 | 2008-10-01 | Boehringer Ingelheim Pharma GmbH & Co. KG | Substituted pyrrolidinamides, their production and utilisation as medicine |
| BRPI0809617A2 (en) | 2007-03-29 | 2014-09-16 | Hoffmann La Roche | NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS |
| CL2008001002A1 (en) | 2007-04-11 | 2008-10-17 | Actelion Pharmaceuticals Ltd | COMPOUNDS DERIVED FROM OXAZOLIDINONA; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUNDS; AND ITS USE TO PREPARE A MEDICINAL PRODUCT TO TREAT A BACTERIAL INFECTION. |
| MX2009011112A (en) | 2007-04-27 | 2009-10-28 | Sanofi Aventis | 2 -heteroaryl- pyrrolo [3, 4-c] pyrrole derivatives and their use as scd inhibitors. |
| DE102007047737A1 (en) | 2007-10-05 | 2009-04-30 | Merck Patent Gmbh | Piperidine and piperazine derivatives |
| ES2830024T3 (en) | 2007-10-19 | 2021-06-02 | Novartis Ag | Compositions and methods for the treatment of macular edema |
| PE20091017A1 (en) | 2007-10-31 | 2009-07-16 | Janssen Pharmaceutica Nv | BRIDGED OR FUSED DIAMINES REPLACED WITH ARYL AS LEUKOTRIENE A4 HYDROLASE MODULATORS |
| JP2009161449A (en) | 2007-12-28 | 2009-07-23 | Lion Corp | Agent for promoting activity of ppar (peroxisome proliferator activated receptor), food and drink good for cosmetic appearance, skin external preparation, and medicine |
| US20110071129A1 (en) | 2008-06-19 | 2011-03-24 | Makoto Ando | Spirodiamine-diaryl ketoxime derivative |
| US8673917B2 (en) | 2008-09-09 | 2014-03-18 | Sanofi | 2-heteroaryl-pyrrolo [3,4-C]pyrrole derivatives, and use thereof as SCD inhibitors |
| TW201020247A (en) | 2008-11-06 | 2010-06-01 | Gruenenthal Gmbh | Substituierte disulfonamide |
| EP2358677B1 (en) | 2008-11-17 | 2014-01-08 | F. Hoffmann-La Roche AG | Naphthylacetic acids used as crth2 antagonists or partial agonists |
| DE102008059578A1 (en) | 2008-11-28 | 2010-06-10 | Merck Patent Gmbh | Benzo-naphthyridine compounds |
| US8530650B2 (en) | 2008-12-01 | 2013-09-10 | Merck Patent Gmbh | 2, 5-diamino-substituted pyrido [4, 3-D] pyrimidines as autotaxin inhibitors against cancer |
| TW201035102A (en) | 2009-03-04 | 2010-10-01 | Gruenethal Gmbh | Sulfonylated tetrahydroazolopyrazines and their use as medicinal products |
| TW201038572A (en) | 2009-03-25 | 2010-11-01 | Gruenenthal Gmbh | Substituted spiro-amide compounds |
| US8841324B2 (en) | 2009-04-02 | 2014-09-23 | Merck Patent Gmbh | Heterocyclic compounds as autotaxin inhibitors |
| CA2757415C (en) | 2009-04-02 | 2018-02-06 | Merck Patent Gmbh | Autotaxin inhibitors |
| ES2775000T3 (en) | 2009-04-02 | 2020-07-23 | Merck Patent Gmbh | Piperidine and piperazine derivatives as autotaxin inhibitors |
| FR2945534B1 (en) | 2009-05-12 | 2012-11-16 | Sanofi Aventis | CYCLOPENTAL [c] PYRROLE-2-CARBOXYLATE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE |
| WO2010135524A1 (en) | 2009-05-22 | 2010-11-25 | Exelixis, Inc. | Benzoxazepines based p13k/mt0r inhibitors against proliferative diseases |
| US20120083476A1 (en) | 2009-06-05 | 2012-04-05 | Janssen Pharmaceutica Nv | Heteroaryl-substituted spirocyclic diamine urea modulators of fatty acid amide hydrolase |
| DE102009033392A1 (en) | 2009-07-16 | 2011-01-20 | Merck Patent Gmbh | Heterocyclic compounds as autotaxine inhibitors II |
| EP2462128B1 (en) | 2009-08-04 | 2016-09-21 | Amira Pharmaceuticals, Inc. | Compounds as lysophosphatidic acid receptor antagonists |
| UA107360C2 (en) | 2009-08-05 | 2014-12-25 | Biogen Idec Inc | Bicyclic aryl sphingosine 1-phosphate analogs |
| AR079022A1 (en) | 2009-11-02 | 2011-12-21 | Sanofi Aventis | DERIVATIVES OF CYCLIC CARBOXYL ACID SUBSTITUTED WITH ACILAMINE, ITS USE AS PHARMACEUTICAL PRODUCTS, PHARMACEUTICAL COMPOSITION AND PREPARATION METHOD |
| EP2521450B1 (en) * | 2010-01-07 | 2015-02-25 | E.I. Du Pont De Nemours And Company | Fungicidal heterocyclic compounds |
| WO2011115813A1 (en) | 2010-03-18 | 2011-09-22 | Abbott Laboratories | Lactam acetamides as calcium channel blockers |
| BR112012023664B1 (en) | 2010-03-19 | 2020-01-28 | Pfizer | COMPOUNDS DERIVED FROM 2,3-DI-HYDRO-1HINDEN-1-IL-2,7- DIAZASPIRO [3,5] NONAN AND PHARMACEUTICAL COMPOSITION UNDERSTANDING THE SAME |
| CN102822171B (en) | 2010-03-26 | 2015-09-02 | 默克专利有限公司 | As the benzo naphthyridines amine of autotaxin inhibitors |
| GB201008005D0 (en) | 2010-05-13 | 2010-06-30 | Sentinel Oncology Ltd | Pharmaceutical compounds |
| EP2575794A2 (en) | 2010-06-04 | 2013-04-10 | B.S.R.C. "Alexander Fleming" | Autotaxin pathway modulation and uses thereof |
| AR082590A1 (en) | 2010-08-12 | 2012-12-19 | Hoffmann La Roche | INHIBITORS OF THE TIROSINA-QUINASA DE BRUTON |
| WO2012024620A2 (en) * | 2010-08-20 | 2012-02-23 | Amira Pharmaceuticals, Inc. | Autotaxin inhibitors and uses thereof |
| CN103189378B (en) * | 2010-09-02 | 2016-03-02 | 默克专利股份公司 | As the Pyrazolopyridine ketone derivatives of LPA receptor antagonist |
| CN104906103B (en) | 2010-12-14 | 2018-05-18 | 电泳有限公司 | Casein kinase 1 δ (CK1 δ) inhibitor |
| WO2012166415A1 (en) | 2011-05-27 | 2012-12-06 | Amira Pharmaceuticals, Inc. | Heterocyclic autotaxin inhibitors and uses thereof |
| EP2751118B1 (en) | 2011-08-29 | 2016-10-12 | Bristol-Myers Squibb Company | Spiro bicyclic diamine derivatives as hiv attachment inhibitors |
| WO2013054185A1 (en) | 2011-10-13 | 2013-04-18 | Pfizer, Inc. | Pyrimidine and pyridine derivatives useful in therapy |
| JPWO2013065712A1 (en) | 2011-10-31 | 2015-04-02 | 東レ株式会社 | Diaza spiro urea derivative and its pharmaceutical use |
| US8809552B2 (en) | 2011-11-01 | 2014-08-19 | Hoffmann-La Roche Inc. | Azetidine compounds, compositions and methods of use |
| CA2856946C (en) | 2011-12-02 | 2016-08-02 | Phenex Pharmaceuticals Ag | Pyrrolo carboxamides as modulators of orphan nuclear receptor rar-related orphan receptor-gamma (rory, nr1f3) activity and for the treatment of chronic inflammatory and autoimmunediseases |
| TWI638802B (en) | 2012-05-24 | 2018-10-21 | 芬蘭商奧利安公司 | Catechol o-methyltransferase activity inhibiting compounds |
| CN104364239B (en) | 2012-06-13 | 2017-08-25 | 霍夫曼-拉罗奇有限公司 | Diaza spiro cycloalkane and azaspiro alkane |
| SG10201610416TA (en) | 2012-06-13 | 2017-01-27 | Incyte Corp | Substituted tricyclic compounds as fgfr inhibitors |
| EP2877166B1 (en) | 2012-07-27 | 2018-02-28 | Biogen MA Inc. | 1-[7-(cis-4-methyl-cyclohexyloxy)-8-trifluoromethyl-naphthalen-2-ylmethyl]-piperidine-4-carboxylic acid derivatives as autotaxin (ATX) modulators for treating inflammations and autoimmune disorders |
| WO2014018891A1 (en) | 2012-07-27 | 2014-01-30 | Biogen Idec Ma Inc. | Compounds that are s1p modulating agents and/or atx modulating agents |
| MX368615B (en) | 2012-09-25 | 2019-10-09 | Hoffmann La Roche | New bicyclic derivatives. |
| PL2900269T3 (en) | 2012-09-25 | 2019-02-28 | Bayer Pharma Aktiengesellschaft | Combination of regorafenib and acetylsalicylic acid for treating colorectal cancer |
| AR092742A1 (en) | 2012-10-02 | 2015-04-29 | Intermune Inc | ANTIFIBROTIC PYRIDINONES |
| EP3842420B1 (en) | 2012-10-25 | 2022-12-07 | Tetra Discovery Partners LLC | Heteroaryl inhibitors of pde4 |
| WO2014133112A1 (en) | 2013-03-01 | 2014-09-04 | 国立大学法人東京大学 | 8-substituted imidazopyrimidinone derivative having autotaxin inhibitory activity |
| TWI593692B (en) | 2013-03-12 | 2017-08-01 | 美國禮來大藥廠 | Tetrahydropyrrolothiazine compounds |
| CA2903483A1 (en) | 2013-03-12 | 2014-10-09 | Acucela Inc. | Substituted 3-phenylpropylamine derivatives for the treatment of ophthalmic diseases and disorders |
| CN108440528A (en) | 2013-03-12 | 2018-08-24 | 艾伯维公司 | Fourth Ring Bu Luomo structural domain inhibitor |
| AR095079A1 (en) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | DERIVATIVES OF OCTAHIDRO-PIRROLO [3,4-C] -PIRROL AND PIRIDINA-FENILO |
| EP2970302A1 (en) | 2013-03-15 | 2016-01-20 | Biogen MA Inc. | S1p and/or atx modulating agents |
| JP6424219B2 (en) | 2013-07-18 | 2018-11-14 | ノバルティス アーゲー | Autotaxin inhibitors comprising a heteroaromatic ring-benzyl-amide-cycle core |
| TR201807411T4 (en) | 2013-10-17 | 2018-06-21 | Vertex Pharma | DNA-PK inhibitors. |
| NZ720478A (en) | 2013-11-22 | 2022-02-25 | Sabre Therapeutics Llc | Autotaxin inhibitor compounds |
| AR098475A1 (en) | 2013-11-26 | 2016-06-01 | Bayer Cropscience Ag | PESTICIDE COMPOUNDS AND USES |
| HUE036117T2 (en) | 2013-11-26 | 2018-06-28 | Hoffmann La Roche | Octahydro-cyclobuta [1,2-c;3,4-c']dipyrrole derivatives as autotaxin inhibitors |
| MA39792B1 (en) | 2014-03-26 | 2019-12-31 | Hoffmann La Roche | Bicyclic compounds as inhibitors of autotaxin (atx) and lysophosphatidic acid (lpa) production |
| JO3512B1 (en) | 2014-03-26 | 2020-07-05 | Astex Therapeutics Ltd | Quinoxaline derivatives useful as fgfr kinase modulators |
| KR20160137619A (en) | 2014-03-26 | 2016-11-30 | 바스프 에스이 | Substituted [1,2,4]triazole and imidazole compounds as fungicides |
| CN106029667B (en) | 2014-03-26 | 2019-08-23 | 豪夫迈·罗氏有限公司 | Condensed [1,4] diaza * compound as autocrine motility factor (ATX) and lysophosphatidic acid (LPA) production inhibitor |
| CN107106559A (en) | 2014-04-04 | 2017-08-29 | X-Rx股份有限公司 | The substituted loop coil inhibitor of autocrine motility factor |
| UA118989C2 (en) | 2014-10-14 | 2019-04-10 | Вітае Фармасьютікалс, Інк. | Dihydropyrrolopyridine inhibitors of ror-gamma |
| JP6700291B2 (en) | 2015-02-15 | 2020-05-27 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 1-(HET)arylsulfonyl-(pyrrolidine or piperidine)-2-carboxamide derivatives and their use as TRPA1 antagonists |
| MA41898A (en) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | BICYCLIC QUINAZOLINONE DERIVATIVES |
| CN104927727B (en) | 2015-07-06 | 2017-01-11 | 香山红叶建设有限公司 | Structural sealant for glass curtain walls and preparation method for structural sealant |
| UA123362C2 (en) | 2015-09-04 | 2021-03-24 | Ф. Хоффманн-Ля Рош Аг | Phenoxymethyl derivatives |
| PL415078A1 (en) | 2015-09-04 | 2017-03-13 | Oncoarendi Therapeutics Spółka Z Ograniczoną Odpowiedzialnością | Substituted amino triazoles, suitable as acidic mammalian chitinase inhibitors |
| JP6877414B2 (en) | 2015-09-24 | 2021-05-26 | アイオニス・ファーマシューティカルズ・インコーポレイテッドＩｏｎｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | KRAS expression modulator |
| CN107614505B (en) | 2015-09-24 | 2021-05-07 | 豪夫迈·罗氏有限公司 | Novel bicyclic compounds as dual ATX/CA inhibitors |
| WO2017050791A1 (en) | 2015-09-24 | 2017-03-30 | F. Hoffmann-La Roche Ag | New bicyclic compounds as dual atx/ca inhibitors |
| CA2991615A1 (en) | 2015-09-24 | 2017-03-30 | F. Hoffmann-La Roche Ag | Bicyclic compounds as atx inhibitors |
| AU2016328535A1 (en) | 2015-09-24 | 2017-11-09 | F. Hoffmann-La Roche Ag | Bicyclic compounds as ATX inhibitors |
| CN114957291A (en) | 2015-11-25 | 2022-08-30 | 达纳-法伯癌症研究所股份有限公司 | Bivalent bromodomain inhibitors and uses thereof |
| KR102070746B1 (en) | 2015-12-01 | 2020-01-29 | 니혼노야쿠가부시키가이샤 | 3H-pyrrolopyridine compound or N-oxide thereof, or salts thereof and agrohorticultural insecticide containing the compound and method of using the same |
| WO2017139978A1 (en) | 2016-02-19 | 2017-08-24 | 吴伟东 | Method and system for updating mobile phone app |
| AU2018233079B9 (en) | 2017-03-16 | 2021-07-22 | F. Hoffmann-La Roche Ag | Heterocyclic compounds useful as dual ATX/CA inhibitors |
| WO2018167113A1 (en) | 2017-03-16 | 2018-09-20 | F. Hoffmann-La Roche Ag | New bicyclic compounds as atx inhibitors |
| PL3448859T3 (en) | 2017-03-20 | 2020-02-28 | Forma Therapeutics, Inc. | Pyrrolopyrrole compositions as pyruvate kinase (pkr) activators |
-
2013
- 2013-09-23 MX MX2015002090A patent/MX368615B/en active IP Right Grant
- 2013-09-23 MA MA37940A patent/MA37940B1/en unknown
- 2013-09-23 SG SG11201500572YA patent/SG11201500572YA/en unknown
- 2013-09-23 WO PCT/EP2013/069679 patent/WO2014048865A1/en active Application Filing
- 2013-09-23 EP EP13766056.9A patent/EP2900669B1/en active Active
- 2013-09-23 AU AU2013322838A patent/AU2013322838B2/en not_active Ceased
- 2013-09-23 AR ARP130103396A patent/AR092645A1/en not_active Application Discontinuation
- 2013-09-23 SI SI201331606T patent/SI2900669T1/en unknown
- 2013-09-23 JP JP2015533548A patent/JP6285444B2/en active Active
- 2013-09-23 RS RS20191402A patent/RS59512B1/en unknown
- 2013-09-23 DK DK13766056T patent/DK2900669T3/en active
- 2013-09-23 EP EP19187624.2A patent/EP3590940B1/en active Active
- 2013-09-23 EA EA201590534A patent/EA036630B1/en not_active IP Right Cessation
- 2013-09-23 HU HUE13766056A patent/HUE045797T2/en unknown
- 2013-09-23 IN IN960DEN2015 patent/IN2015DN00960A/en unknown
- 2013-09-23 CA CA2878442A patent/CA2878442A1/en active Pending
- 2013-09-23 PE PE2015000230A patent/PE20150758A1/en active IP Right Grant
- 2013-09-23 BR BR112015004111A patent/BR112015004111A2/en active Search and Examination
- 2013-09-23 PT PT137660569T patent/PT2900669T/en unknown
- 2013-09-23 UA UAA201503793A patent/UA116547C2/en unknown
- 2013-09-23 CN CN201380049392.4A patent/CN104684915B/en active Active
- 2013-09-23 LT LT13766056T patent/LT2900669T/en unknown
- 2013-09-23 PL PL13766056T patent/PL2900669T3/en unknown
- 2013-09-23 KR KR1020157007381A patent/KR102179599B1/en active IP Right Grant
- 2013-09-23 ES ES13766056T patent/ES2753163T3/en active Active
- 2013-09-24 TW TW102134348A patent/TWI609018B/en not_active IP Right Cessation
-
2015
- 2015-01-16 ZA ZA2015/00345A patent/ZA201500345B/en unknown
- 2015-02-05 IL IL237126A patent/IL237126A/en active IP Right Grant
- 2015-02-06 PH PH12015500263A patent/PH12015500263B1/en unknown
- 2015-03-06 CR CR20150120A patent/CR20150120A/en unknown
- 2015-03-20 CL CL2015000706A patent/CL2015000706A1/en unknown
- 2015-05-21 US US14/719,063 patent/US20150353559A1/en not_active Abandoned
- 2015-07-27 HK HK15107163.9A patent/HK1206722A1/en unknown
-
2016
- 2016-10-12 US US15/291,933 patent/US20170050960A1/en not_active Abandoned
-
2017
- 2017-05-01 US US15/583,679 patent/US10669268B2/en active Active
-
2019
- 2019-10-23 HR HRP20191937TT patent/HRP20191937T1/en unknown
-
2020
- 2020-03-13 US US16/818,409 patent/US20200339570A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IN2015DN00960A (en) | ||
| PH12014502697A1 (en) | New diazaspirocycloalkane and azaspirocycloalkane | |
| MX2020004504A (en) | Phenoxymethyl derivatives. | |
| IN2014MN02574A (en) | ||
| MX2018001430A (en) | New bicyclic compounds as dual atx/ca inhibitors. | |
| PH12014501179B1 (en) | New bicyclic dihydroisoquinoline-1-one derivatives | |
| MY169043A (en) | New dihydroquinoline-2-one derivatives | |
| MX341133B (en) | Compounds and methods. | |
| MX2014014531A (en) | Aminoquinazoline and pyridopyrimidine derivatives. | |
| MX2018001890A (en) | Bicyclic compounds as atx inhibitors. | |
| MY163187A (en) | Novel imidazo-oxazine compound or salt thereof | |
| MY169267A (en) | New aryl-quinoline derivatives | |
| PH12016500643A1 (en) | New octahydro - cyclobuta [1,2-c;3,4-c`] dipyrrol -2- yl | |
| IN2015DN00598A (en) | ||
| MX341456B (en) | Amino-quinolines as kinase inhibitors. | |
| MX2012008141A (en) | Compounds and methods. | |
| MX2015001099A (en) | New bicyclicpyridine derivatives. | |
| MX2015007097A (en) | Novel bi-ring phenyl-pyridines/pyrazines for the treatment of cancer. | |
| PH12015500315A1 (en) | Substituted pyrozales as n-type calcium channel blockers | |
| MX2015010106A (en) | Flap modulators. | |
| MX2015016332A (en) | Pyrrolotriazines as alk inhibitors. | |
| MX2015014470A (en) | Combretastatin analogs. | |
| MX342311B (en) | New azaspirodecanone compounds as hsl inhibitors. | |
| MX2013009386A (en) | New azaspirodecanone compounds. | |
| MX346980B (en) | New hexahydrocyclopentapyrrolone, hexahydropyrrolopyrrolone, octahydropyrrolopyridinone and octahydropyridinone compounds. |