IN2015DN00837A - - Google Patents
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- Publication number
- IN2015DN00837A IN2015DN00837A IN837DEN2015A IN2015DN00837A IN 2015DN00837 A IN2015DN00837 A IN 2015DN00837A IN 837DEN2015 A IN837DEN2015 A IN 837DEN2015A IN 2015DN00837 A IN2015DN00837 A IN 2015DN00837A
- Authority
- IN
- India
- Prior art keywords
- compounds
- optionally substituted
- hydrogen atom
- methods
- substituted alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
Abstract
The invention relates to new derivatives of 5-aminolevulinic acid (5-ALA) and their use as photosensitizing agents. In particular, it relates to compounds of general formula I and their pharmaceutically acceptable salts, to methods for preparing such compounds and their medical and cosmetic use, for example in methods of photodynamic therapy and diagnosis: wherein R 1 represents a hydrogen atom or an optionally substituted alkyl or cycloalkyl group; R2, each of which may be the same or different, represents a hydrogen atom or an optionally substituted alkyl group; and X is a linking group.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12179277 | 2012-08-03 | ||
EP12197305 | 2012-12-14 | ||
PCT/EP2013/066317 WO2014020164A1 (en) | 2012-08-03 | 2013-08-02 | Compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2015DN00837A true IN2015DN00837A (en) | 2015-06-12 |
Family
ID=48948407
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN837DEN2015 IN2015DN00837A (en) | 2012-08-03 | 2013-08-02 |
Country Status (19)
Country | Link |
---|---|
US (1) | US9249086B2 (en) |
EP (1) | EP2880012B1 (en) |
JP (1) | JP6280117B2 (en) |
KR (1) | KR102180174B1 (en) |
CN (1) | CN104661994B (en) |
AU (1) | AU2013298525B2 (en) |
BR (1) | BR112015002390B1 (en) |
CA (1) | CA2880422C (en) |
CL (1) | CL2015000233A1 (en) |
ES (1) | ES2908080T3 (en) |
HK (1) | HK1211283A1 (en) |
IL (1) | IL236965B (en) |
IN (1) | IN2015DN00837A (en) |
MX (1) | MX364940B (en) |
NZ (1) | NZ629914A (en) |
RU (1) | RU2635563C2 (en) |
SG (1) | SG11201500805VA (en) |
WO (1) | WO2014020164A1 (en) |
ZA (1) | ZA201500778B (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6595484B2 (en) | 2013-12-20 | 2019-10-23 | ガルデルマ・リサーチ・アンド・デヴェロップメント | Pulsed photodynamic treatment of photodamaged skin |
EP3353145B1 (en) * | 2015-09-23 | 2022-09-28 | XWPharma Ltd. | Prodrugs of gamma-hydroxybutyric acid, compositions and uses thereof |
KR20180094986A (en) * | 2015-12-17 | 2018-08-24 | 포토큐어 에이에스에이 | Methods of photodynamic therapy (PDT) for bladder cancer |
GB201522398D0 (en) | 2015-12-18 | 2016-02-03 | Photocure As | Device for photodynamic therapy |
CN106187793A (en) * | 2016-01-26 | 2016-12-07 | 赵鸣 | 5 aminolevulinic acids and the salt compound of derivant thereof and application |
FI3641882T3 (en) * | 2017-06-21 | 2023-12-14 | Photocure Asa | Method for preparing a liquid pharmaceutical composition and device for use in such method |
EP4349401A1 (en) | 2019-02-13 | 2024-04-10 | Alpheus Medical, Inc. | Non-invasive sonodynamic therapy |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07188133A (en) | 1993-12-27 | 1995-07-25 | Asahi Chem Ind Co Ltd | Production of delta-aminolevulinic acid or its homologue |
US7530461B2 (en) | 1995-03-10 | 2009-05-12 | Photocure Asa | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy |
US6492420B2 (en) | 1995-03-10 | 2002-12-10 | Photocure As | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy |
US6992107B1 (en) | 1995-03-10 | 2006-01-31 | Photocure Asa | Esters of 5-aminolevulinic acid and their use as photosensitizing compounds in photochemotherapy |
CZ291132B6 (en) * | 1995-03-10 | 2002-12-11 | Photocure Asa | Esters of 5-aminolevullinic acids and pharmaceutical preparation in which the esters are comprised |
JPH1112197A (en) | 1997-06-18 | 1999-01-19 | Cosmo Sogo Kenkyusho:Kk | Malignant tumor diagnostic agent and therapeutic agent |
GB0018528D0 (en) | 2000-07-27 | 2000-09-13 | Photocure Asa | Compounds |
DE10202487A1 (en) | 2002-01-23 | 2003-07-31 | Photonamic Gmbh & Co Kg | Dermal application system for aminolevulinic acid derivatives |
DE10312659A1 (en) | 2003-03-21 | 2004-10-07 | Universität Regensburg | New 5-aminolevulinic acid derivatives useful for photodynamic tumor therapy and/or diagnosis |
GB0406917D0 (en) | 2004-03-26 | 2004-04-28 | Photocure Asa | Compounds |
CN1942430B (en) * | 2004-03-30 | 2011-04-20 | 克斯莫石油株式会社 | 5-aminolevulinic acid phosphate, method for producing the same and use thereof |
JP4417865B2 (en) | 2004-03-30 | 2010-02-17 | コスモ石油株式会社 | 5-Aminolevulinic acid phosphate, method for producing the same, and use thereof |
JP4719483B2 (en) | 2004-03-30 | 2011-07-06 | コスモ石油株式会社 | Process for producing 5-aminolevulinic acid sulfonate |
GB0424833D0 (en) * | 2004-11-10 | 2004-12-15 | Photocure Asa | Method |
JP5404995B2 (en) | 2006-08-10 | 2014-02-05 | コスモ石油株式会社 | Plant polyphenol extender |
JP5039389B2 (en) | 2007-02-02 | 2012-10-03 | コスモ石油株式会社 | Hop alpha acid or hop oil content improver |
ES2550243T3 (en) | 2007-03-30 | 2015-11-05 | Cosmo Ala Co., Ltd. | Agent to improve the alkali resistance of a plant and method to improve the alkali resistance of a plant |
JP4705616B2 (en) | 2007-07-20 | 2011-06-22 | コスモ石油株式会社 | Absorption enhancer of metal components in plants |
GB0724279D0 (en) * | 2007-12-12 | 2008-01-23 | Photocure Asa | Use |
EP2231105A1 (en) * | 2007-12-14 | 2010-09-29 | Photoderma SA | Novel compounds useful in therapeutic and cosmetic methods |
CA2721042C (en) | 2008-04-22 | 2017-07-11 | Sbi Alapromo Co., Ltd. | Method of detecting bladder cancer |
EP2274979B8 (en) | 2008-05-13 | 2016-10-12 | COSMO TRaDE & SERVICE CO., LTD. | Agent for improving lawn grass qualities |
JP5276894B2 (en) | 2008-05-13 | 2013-08-28 | コスモ石油株式会社 | Rice seedling raising improver |
JP5323539B2 (en) | 2009-03-11 | 2013-10-23 | コスモ石油株式会社 | Yield improver for crop crops |
-
2013
- 2013-08-02 IN IN837DEN2015 patent/IN2015DN00837A/en unknown
- 2013-08-02 ES ES13745829T patent/ES2908080T3/en active Active
- 2013-08-02 EP EP13745829.5A patent/EP2880012B1/en active Active
- 2013-08-02 MX MX2015001374A patent/MX364940B/en active IP Right Grant
- 2013-08-02 SG SG11201500805VA patent/SG11201500805VA/en unknown
- 2013-08-02 AU AU2013298525A patent/AU2013298525B2/en active Active
- 2013-08-02 JP JP2015524805A patent/JP6280117B2/en active Active
- 2013-08-02 KR KR1020157003692A patent/KR102180174B1/en active IP Right Grant
- 2013-08-02 RU RU2015104830A patent/RU2635563C2/en active
- 2013-08-02 CA CA2880422A patent/CA2880422C/en active Active
- 2013-08-02 BR BR112015002390-8A patent/BR112015002390B1/en active IP Right Grant
- 2013-08-02 NZ NZ629914A patent/NZ629914A/en unknown
- 2013-08-02 WO PCT/EP2013/066317 patent/WO2014020164A1/en active Application Filing
- 2013-08-02 US US14/419,125 patent/US9249086B2/en active Active
- 2013-08-02 CN CN201380048873.3A patent/CN104661994B/en active Active
-
2015
- 2015-01-28 IL IL236965A patent/IL236965B/en active IP Right Grant
- 2015-01-30 CL CL2015000233A patent/CL2015000233A1/en unknown
- 2015-02-03 ZA ZA2015/00778A patent/ZA201500778B/en unknown
- 2015-12-09 HK HK15112157.7A patent/HK1211283A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
SG11201500805VA (en) | 2015-02-27 |
WO2014020164A1 (en) | 2014-02-06 |
US20150191419A1 (en) | 2015-07-09 |
KR102180174B1 (en) | 2020-11-19 |
CA2880422A1 (en) | 2014-02-06 |
HK1211283A1 (en) | 2016-05-20 |
CA2880422C (en) | 2021-02-09 |
KR20150039208A (en) | 2015-04-09 |
CN104661994B (en) | 2017-08-08 |
AU2013298525B2 (en) | 2017-12-14 |
IL236965B (en) | 2019-03-31 |
JP2015528814A (en) | 2015-10-01 |
BR112015002390A2 (en) | 2017-07-04 |
US9249086B2 (en) | 2016-02-02 |
BR112015002390B1 (en) | 2020-03-24 |
ZA201500778B (en) | 2016-04-28 |
EP2880012A1 (en) | 2015-06-10 |
JP6280117B2 (en) | 2018-02-14 |
RU2635563C2 (en) | 2017-11-14 |
EP2880012B1 (en) | 2021-12-15 |
CL2015000233A1 (en) | 2015-04-24 |
CN104661994A (en) | 2015-05-27 |
MX2015001374A (en) | 2015-09-07 |
ES2908080T3 (en) | 2022-04-27 |
AU2013298525A1 (en) | 2015-03-05 |
NZ629914A (en) | 2017-02-24 |
MX364940B (en) | 2019-05-15 |
BR112015002390A8 (en) | 2019-07-30 |
RU2015104830A (en) | 2016-09-27 |
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