IN2014CN04470A - - Google Patents

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Publication number
IN2014CN04470A
IN2014CN04470A IN4470CHN2014A IN2014CN04470A IN 2014CN04470 A IN2014CN04470 A IN 2014CN04470A IN 4470CHN2014 A IN4470CHN2014 A IN 4470CHN2014A IN 2014CN04470 A IN2014CN04470 A IN 2014CN04470A
Authority
IN
India
Prior art keywords
ketoreductase polypeptides
preparation
present disclosure
making
methods
Prior art date
Application number
Inventor
Fabien Cabirol
Haibin Chen
Anupam Gohel
Steven J Collier
Derek Smith
Birgit Kosjek
Jacob Janey
Original Assignee
Codexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codexis Inc filed Critical Codexis Inc
Publication of IN2014CN04470A publication Critical patent/IN2014CN04470A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01184—Carbonyl reductase (NADPH) (1.1.1.184)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present disclosure relates to engineered ketoreductase polypeptides for the preparation of hydroxyl substituted carbamate compounds and polynucleotides vectors host cells and methods of making and using the ketoreductase polypeptides.
IN4470CHN2014 2011-11-18 2012-11-14 IN2014CN04470A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161561665P 2011-11-18 2011-11-18
PCT/US2012/065046 WO2013074650A1 (en) 2011-11-18 2012-11-14 Biocatalysts for the preparation of hydroxy substituted carbamates

Publications (1)

Publication Number Publication Date
IN2014CN04470A true IN2014CN04470A (en) 2015-09-04

Family

ID=47295185

Family Applications (1)

Application Number Title Priority Date Filing Date
IN4470CHN2014 IN2014CN04470A (en) 2011-11-18 2012-11-14

Country Status (8)

Country Link
US (8) US9139819B2 (en)
EP (1) EP2780448B1 (en)
CN (2) CN104053771B (en)
HU (1) HUE046089T2 (en)
IL (1) IL232621B (en)
IN (1) IN2014CN04470A (en)
SG (1) SG11201402401TA (en)
WO (1) WO2013074650A1 (en)

Families Citing this family (10)

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US7977078B2 (en) 2007-08-24 2011-07-12 Codexis, Inc. Ketoreductase polypeptides for the production of (R)-3-hydroxythiolane
JP6088535B2 (en) 2011-10-27 2017-03-08 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． Process for producing beta 3 agonists and intermediates
EP2770996B1 (en) 2011-10-27 2016-09-28 Merck Sharp & Dohme Corp. Process for making beta 3 agonists and intermediates
WO2013074650A1 (en) 2011-11-18 2013-05-23 Codexis, Inc. Biocatalysts for the preparation of hydroxy substituted carbamates
WO2014150633A1 (en) * 2013-03-15 2014-09-25 Merck Sharp & Dohme Corp. Immobilized ketoreductases and process for making and using immobilized ketoreductase
HUE045260T2 (en) * 2013-03-15 2019-12-30 Merck Sharp & Dohme Process for preparing beta 3 agonists and intermediates
EP3256577B1 (en) * 2015-02-10 2020-08-26 Codexis, Inc. Ketoreductase polypeptides for the synthesis of chiral compounds
CN106011095B (en) * 2016-07-27 2021-02-26 苏州汉酶生物技术有限公司 Engineered ketoreductase polypeptide and method for preparing ezetimibe intermediate by using same
CN109943543B (en) * 2019-03-28 2020-12-11 上海健康医学院 Alcohol dehydrogenase mutant and preparation method and application thereof
CN114410599B (en) * 2022-01-29 2023-08-18 浙江工业大学 Carbonyl reductase mutant and application thereof in preparation of rosuvastatin chiral intermediate

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Also Published As

Publication number Publication date
US9139819B2 (en) 2015-09-22
SG11201402401TA (en) 2014-06-27
US20160319247A1 (en) 2016-11-03
US11713451B2 (en) 2023-08-01
US20140322769A1 (en) 2014-10-30
HUE046089T2 (en) 2020-01-28
US10851351B2 (en) 2020-12-01
CN104053771B (en) 2016-11-09
CN106479990A (en) 2017-03-08
US20150344850A1 (en) 2015-12-03
WO2013074650A1 (en) 2013-05-23
US20180371427A1 (en) 2018-12-27
US20180010100A1 (en) 2018-01-11
EP2780448A1 (en) 2014-09-24
EP2780448B1 (en) 2019-09-11
IL232621A0 (en) 2014-06-30
US10100287B2 (en) 2018-10-16
CN106479990B (en) 2020-09-18
US20240018489A1 (en) 2024-01-18
US9422531B2 (en) 2016-08-23
US20210071151A1 (en) 2021-03-11
US10253303B2 (en) 2019-04-09
US20190177702A1 (en) 2019-06-13
IL232621B (en) 2019-10-31
CN104053771A (en) 2014-09-17
US9803178B2 (en) 2017-10-31

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