IN2013MU01967A - - Google Patents

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Publication number
IN2013MU01967A
IN2013MU01967A IN1967MU2013A IN2013MU01967A IN 2013MU01967 A IN2013MU01967 A IN 2013MU01967A IN 1967MU2013 A IN1967MU2013 A IN 1967MU2013A IN 2013MU01967 A IN2013MU01967 A IN 2013MU01967A
Authority
IN
India
Prior art keywords
phenoxyphosphinyl
isopropoxycarbonyl
adenine
methoxy
propyl
Prior art date
Application number
Inventor
Ashwini Amol Sawant
Dharmaraj Ramachandra Rao
Nayan Shivalkar
Nitin Thakur
Original Assignee
Cipla Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cipla Ltd filed Critical Cipla Ltd
Priority to CA2914381A priority Critical patent/CA2914381A1/en
Priority to US14/896,313 priority patent/US9676803B2/en
Priority to PCT/GB2014/051752 priority patent/WO2014195724A1/en
Priority to EP14732301.8A priority patent/EP3004121A1/en
Priority to ZA2014/04147A priority patent/ZA201404147B/en
Priority to IN1967MU2013 priority patent/IN2013MU01967A/en
Publication of IN2013MU01967A publication Critical patent/IN2013MU01967A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Abstract The present invention relates to an efficient process for the separation of diastereomers of 9-[(R)-2-[[(R,S)-[[(S)-1-(Isopropoxycarbonyl)ethyl]amino]-phenoxyphosphinyl]methoxy]propyl]adenine and to a process for preparing 9-[(R)-2-[[(R)-[[(S)-1-(Isopropoxycarbonyl)ethyl]amino]phenoxyphosphinyl]methoxy]propyl]adenine and 9-[(R)-2-[[(S)-[[(S)-1-(Isopropoxycarbonyl)ethyl]amino]phenoxyphosphinyl]methoxy]propyl] adenine.
IN1967MU2013 2013-06-07 2014-06-06 IN2013MU01967A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA2914381A CA2914381A1 (en) 2013-06-07 2014-06-06 An efficient process for separation of diastereomers of 9-[(r)-2-[[(r,s)-[[(s)-1-(isopropoxycarbonyl)ethyl]amino]-phenoxyphosphinyl] methoxy]propyl]adenine
US14/896,313 US9676803B2 (en) 2013-06-07 2014-06-06 Efficient process for separation of diastereomers of 9-[(R)-2-[[(R,S)-[[(S)-1-(isopropoxycarbonyl)ethyl]amino]-phenoxyphosphinyl]methoxy]propyl]adenine
PCT/GB2014/051752 WO2014195724A1 (en) 2013-06-07 2014-06-06 An efficient process for separation of diastereomers of 9-[(r)-2-[[(r,s)-[[(s)-1-(isopropoxycarbonyl)ethyl]amino]-phenoxyphosphinyl] methoxy]propyl]adenine
EP14732301.8A EP3004121A1 (en) 2013-06-07 2014-06-06 An efficient process for separation of diastereomers of 9-[(r)-2-[[(r,s)-[[(s)-1-(isopropoxycarbonyl)ethyl]amino]-phenoxyphosphinyl]methoxy]propyl]adenine
ZA2014/04147A ZA201404147B (en) 2013-06-07 2014-06-06 An efficient process for separation of diastereomers of 9-[(r)-2-[[(r,s)-[[(s)-1-(isopropoxycarbonyl)ethyl]amino]-phenoxyphosphinyl] methoxy]propyl]adenine
IN1967MU2013 IN2013MU01967A (en) 2013-06-07 2014-06-06

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN1967MU2013 IN2013MU01967A (en) 2013-06-07 2014-06-06

Publications (1)

Publication Number Publication Date
IN2013MU01967A true IN2013MU01967A (en) 2015-06-12

Family

ID=50981561

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1967MU2013 IN2013MU01967A (en) 2013-06-07 2014-06-06

Country Status (6)

Country Link
US (1) US9676803B2 (en)
EP (1) EP3004121A1 (en)
CA (1) CA2914381A1 (en)
IN (1) IN2013MU01967A (en)
WO (1) WO2014195724A1 (en)
ZA (1) ZA201404147B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9676803B2 (en) 2013-06-07 2017-06-13 Cipla Limited Efficient process for separation of diastereomers of 9-[(R)-2-[[(R,S)-[[(S)-1-(isopropoxycarbonyl)ethyl]amino]-phenoxyphosphinyl]methoxy]propyl]adenine

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015107451A2 (en) * 2014-01-14 2015-07-23 Mylan Laboratories Ltd. Purification of tenofovir alafenamide and its intermediates
CN105085571A (en) * 2014-05-20 2015-11-25 四川海思科制药有限公司 Tenofovir alafenamide compound, preparation method and purpose thereof
CZ2015384A3 (en) * 2015-06-05 2016-12-14 Zentiva, K.S. Tenofovir alafenamide solid forms
JP2018524308A (en) * 2015-06-17 2018-08-30 ギリアード サイエンシーズ， インコーポレイテッド Co-crystals, salts and crystalline forms of tenofovir arafenamide
WO2017118928A1 (en) 2016-01-06 2017-07-13 Lupin Limited Process for the separation of diastereomers of tenofovir alafenamide
CZ2016156A3 (en) 2016-03-17 2017-09-27 Zentiva, K.S. The method of preparation of diastereomerically pure Tenofovir Alafenamide or its salts
WO2017203395A1 (en) * 2016-05-21 2017-11-30 Shilpa Medicare Limited Crystalline forms of tenofovir alafenamide hemi fumarate
TW202402300A (en) 2017-01-31 2024-01-16 美商基利科學股份有限公司 Crystalline forms of tenofovir alafenamide
CN108484672A (en) * 2018-05-23 2018-09-04 中国药科大学制药有限公司 The chiral separation method of the third tenofovir of phosphorus
CN110283208B (en) * 2018-06-22 2022-07-08 南京济群医药科技股份有限公司 Chiral resolution method of tenofovir alafenamide
US11667656B2 (en) 2021-01-27 2023-06-06 Apotex Inc. Crystalline forms of Tenofovir alafenamide

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL213214B1 (en) 2000-07-21 2013-01-31 Gilead Sciences Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same
WO2013052094A2 (en) * 2011-10-07 2013-04-11 Gilead Sciences, Inc. Methods for preparing anti-viral nucleotide analogs
US9676803B2 (en) 2013-06-07 2017-06-13 Cipla Limited Efficient process for separation of diastereomers of 9-[(R)-2-[[(R,S)-[[(S)-1-(isopropoxycarbonyl)ethyl]amino]-phenoxyphosphinyl]methoxy]propyl]adenine

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9676803B2 (en) 2013-06-07 2017-06-13 Cipla Limited Efficient process for separation of diastereomers of 9-[(R)-2-[[(R,S)-[[(S)-1-(isopropoxycarbonyl)ethyl]amino]-phenoxyphosphinyl]methoxy]propyl]adenine

Also Published As

Publication number Publication date
US20160122373A1 (en) 2016-05-05
CA2914381A1 (en) 2014-12-11
WO2014195724A1 (en) 2014-12-11
ZA201404147B (en) 2016-01-27
EP3004121A1 (en) 2016-04-13
US9676803B2 (en) 2017-06-13

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